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Nicholas LaRusso

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Laura E Moreno-Luna; K V Narayanan Menon; Ricardo Paz-Fumagalli; William Sanchez; Seth W Slettedahl; Terry M Therneau; Gregory A Wiseman; Ju Dong Yang; Steven R Alberts; James C Andrews; Piet C de Groen; Chad J Fleming; Denise N Gansen; Gregory J Gores; William S Harmsen; Denise M Harnois; Nicholas F LaRusso; Konstantinos N Lazaridis; Teresa A Mettler; Lewis R Roberts
Efficacy and safety of transarterial radioembolization versus chemoembolization in patients with hepatocellular carcinoma.
Guoku Hu; Bing Q Huang; Nicholas F LaRusso; Amanda L Roth; Honorine D Ward; Guan Zhu; Ai-Yu Gong; Nancy D Hanson; Xian-Ming Chen
Release of Luminal Exosomes Contributes to TLR4-Mediated Epithelial Antimicrobial Defense.
Sergio A Gradilone; Bing Q Huang; Pamela S Bogert; Gabriella B Gajdos; Brynn N Radtke; Nicholas F LaRusso
HDAC6 inhibition restores ciliary expression and decreases tumor growth.

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2013: Laura E Moreno-Luna; K V Narayanan Menon; Ricardo Paz-Fumagalli; William Sanchez; Seth W Slettedahl; Terry M Therneau; Gregory A Wiseman; Ju Dong Yang; Steven R Alberts; James C Andrews; Piet C de Groen; Chad J Fleming; Denise N Gansen; Gregory J Gores; William S Harmsen; Denise M Harnois; Nicholas F LaRusso; Konstantinos N Lazaridis; Teresa A Mettler; Lewis R Roberts
Efficacy and safety of transarterial radioembolization versus chemoembolization in patients with hepatocellular carcinoma.
Cardiovascular and interventional radiology 2013;36(3):714-23.
2013: Guoku Hu; Bing Q Huang; Nicholas F LaRusso; Amanda L Roth; Honorine D Ward; Guan Zhu; Ai-Yu Gong; Nancy D Hanson; Xian-Ming Chen
Release of Luminal Exosomes Contributes to TLR4-Mediated Epithelial Antimicrobial Defense.
PLoS pathogens 2013;9(4):e1003261.
2013: Sergio A Gradilone; Bing Q Huang; Pamela S Bogert; Gabriella B Gajdos; Brynn N Radtke; Nicholas F LaRusso
HDAC6 inhibition restores ciliary expression and decreases tumor growth.
Cancer research 2013;73(7):2259-70.
2013: Steven P O'Hara; Patrick L Splinter; James H Tabibian; Nicholas F LaRusso
The dynamic biliary epithelia: molecules, pathways, and disease.
Journal of hepatology 2013;58(3):575-82.
2013: Sandhya Pruthi; Kevin J Stange; Kashmira S Chawla; Nicholas F LaRusso; Gerald D Malagrino; Judith S Kaur
Successful implementation of a telemedicine-based counseling program for high-risk patients with breast cancer.
Mayo Clinic proceedings. Mayo Clinic 2013;88(1):68-73.
2012: Xiaofang Wang; Christopher J Ward; Hong Ye; Billy K C Chow; Jessica Y S Chu; Peter C Harris; Nicholas F LaRusso; Tatyana V Masyuk; Vicente E Torres
Insignificant effect of secretin in rodent models of polycystic kidney and liver disease.
American journal of physiology. Renal physiology 2012;303(7):F1089-98.
2012: Marie C Hogan; David R Holmes; Maria V Irazabal; Bohyun Kim; Bernard F King; Nicholas F LaRusso; Xujian Li; Tetyana V Masyuk; Linda Page; Eric J Bergstralh; James F Glockner; Vicente E Torres
Somatostatin analog therapy for severe polycystic liver disease: results after 2 years.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012;27(9):3532-9.
2012: Jesús M Banales; Luis Bujanda; Juan F Medina; Jesús Prieto; Elena Sáez; Sarai Sarvide; Patrick Splinter; Pamela S Tietz Bogert; Miriam Uriz; Aura D Urribarri; Nicholas F LaRusso
Up-regulation of microRNA 506 leads to decreased Cl-/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2012;56(2):687-97.
2012: James H Tabibian; Steven P O'Hara; Nicholas F LaRusso
Primary sclerosing cholangitis: the gut-liver axis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2012;10(7):819; author reply 819-20.
2012: Tatyana V Masyuk; Brynn N Radtke; Erik L Ritman; Angela J Stroope; Christopher J Ward; Jason L Bakeberg; Jesús M Banales; Natasha Chandok; Gabriella Bedekovicsne Gajdos; Sergio A Gradilone; Hiroaki Kiyokawa; Anatoliy I Masyuk; Nicholas F LaRusso
Inhibition of Cdc25A suppresses hepato-renal cystogenesis in rodent models of polycystic kidney and liver disease.
Gastroenterology 2012;142(3):622-633.e4.
2012: Sumeet K Asrani; Nicholas F LaRusso
Fibrolamellar hepatocellular carcinoma presenting with Budd-Chiari syndrome, right atrial thrombus, and pulmonary emboli.
Hepatology (Baltimore, Md.) 2012;55(3):977-8.
2011: Mary A Severson; Barbara R Spurrier; Douglas L Wood; Laura G Lee; Adam C Rees; Kimberly H Savoleinen; David C Agerter; Joan K Broers; Christine N Chastain; Carol P Holtz; Nicholas F LaRusso
Health reform: a community experience using design research as a guide.
Mayo Clinic proceedings. Mayo Clinic 2011;86(10):973-80.
2011: Robert C Huebert; Jagavelu Kumaravelu; Nicholas F LaRusso; Juan P Arab; Helen I Hendrickson; Patrick L Splinter; Christy E Trussoni; Meher M Vasdev; Vijay H Shah
Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive microRNAs.
The American journal of pathology 2011;179(4):1851-60.
2011: Steven P O'Hara; Christy E Trussoni; Pamela S Tietz Bogert; Xianming Chen; Nicholas F LaRusso
TLR4 promotes Cryptosporidium parvum clearance in a mouse model of biliary cryptosporidiosis.
The Journal of parasitology 2011;97(5):813-21.
2011: Steven P O'Hara; Patrick L Splinter; Christy E Trussoni; Gabriella B Gajdos; Pooja N Lineswala; Nicholas F LaRusso
Cholangiocyte N-Ras protein mediates lipopolysaccharide-induced interleukin 6 secretion and proliferation.
The Journal of biological chemistry 2011;286(35):30352-60.
2011: Srikar R Guntaka; Nicholas F LaRusso; Geetha Samak; Ankur Seth; Radhakrishna Rao
Epidermal growth factor protects the apical junctional complexes from hydrogen peroxide in bile duct epithelium.
Laboratory investigation; a journal of technical methods and pathology 2011;91(9):1396-409.
2011: Nicholas F LaRusso
Patients, cells, and organelles: the intersection of science and serendipity.
Hepatology (Baltimore, Md.) 2011;53(5):1417-26.
2011: Nicholas F LaRusso; Tatyana V Masyuk
The role of cilia in the regulation of bile flow.
Digestive diseases (Basel, Switzerland) 2011;29(1):6-12.
2010: Kantima Ninlawan; Steve P O'Hara; Patrick L Splinter; Puangrat Yongvanit; Sasithorn Kaewkes; Arpa Surapaitoon; Nicholas F LaRusso; Banchob Sripa
Opisthorchis viverrini excretory/secretory products induce toll-like receptor 4 upregulation and production of interleukin 6 and 8 in cholangiocyte.
Parasitology international 2010;59(4):616-21.
2010: Robert C Huebert; Jagavelu Kumaravelu; Ann F Liebl; Bing Q Huang; Patrick L Splinter; Nicholas F LaRusso; Raul A Urrutia; Vijay H Shah
Immortalized liver endothelial cells: a cell culture model for studies of motility and angiogenesis.
Laboratory investigation; a journal of technical methods and pathology 2010;90(12):1770-81.
2010: Anatoliy I Masyuk; Bing Q Huang; Christopher J Ward; Sergio A Gradilone; Jesus M Banales; Tatyana V Masyuk; Brynn Radtke; Patrick L Splinter; Nicholas F LaRusso
Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia.
American journal of physiology. Gastrointestinal and liver physiology 2010;299(4):G990-9.
2010: Robert C Huebert; Meher M Vasdev; Uday Shergill; Amitava Das; Bing Q Huang; Michael R Charlton; Nicholas F LaRusso; Vijay H Shah
Aquaporin-1 facilitates angiogenic invasion in the pathological neovasculature that accompanies cirrhosis.
Hepatology (Baltimore, Md.) 2010;52(1):238-48.
2010: Steven P O'Hara; Gabriella B Gajdos; Christy E Trussoni; Patrick L Splinter; Nicholas F LaRusso
Cholangiocyte myosin IIB is required for localized aggregation of sodium glucose cotransporter 1 to sites of Cryptosporidium parvum cellular invasion and facilitates parasite internalization.
Infection and immunity 2010;78(7):2927-36.
2010: Sergio A Gradilone; Tatyana V Masyuk; Bing Q Huang; Jesús M Banales; Guillermo L Lehmann; Brynn N Radtke; Angela Stroope; Anatoliy I Masyuk; Patrick L Splinter; Nicholas F LaRusso
Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD.
Gastroenterology 2010;139(1):304-14.e2.
2010: Marie C Hogan; Tatyana V Masyuk; Linda J Page; Vickie J Kubly; Eric J Bergstralh; Xujian Li; Bohyun Kim; Bernard F King; James F Glockner; David R Holmes; Sandro Rossetti; Peter C Harris; Nicholas F LaRusso; Vicente E Torres
Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and liver disease.
Journal of the American Society of Nephrology : JASN 2010;21(6):1052-61.
2010: Steven P O'Hara; Patrick L Splinter; Gabriella B Gajdos; Christy E Trussoni; Martin E Fernandez Zapico; Xian-Ming Chen; Nicholas F LaRusso
NFkappaB p50-CCAAT/enhancer-binding protein beta (C/EBPbeta)-mediated transcriptional repression of microRNA let-7i following microbial infection.
The Journal of biological chemistry 2010;285(1):216-25.
2009: Florin Selaru; Alexandru Olaru; Takatsugu Kan; Stefan David; Yulan Cheng; Yuriko Mori; Jian Yang; Bogdan Paun; Zhe Jin; Rachana Agarwal; James P Hamilton; John M Abraham; Christos S Georgiades; Hector Alvarez; Perumal Vivekanandan; Wayne Yu; Anirban Maitra; Michael Torbenson; Paul J Thuluvath; Gregory J Gores; Nicholas F LaRusso; Ralph Hruban; Meltzer Stephen J.
MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3.
Hepatology (Baltimore, Md.) 2009;49(5):1595-601.
2009: Steven P O'Hara; Aaron J Small; Gabriella B Gajdos; andrew badley; Xian-Ming Chen; Nicholas F LaRusso
HIV-1 Tat protein suppresses cholangiocyte toll-like receptor 4 expression and defense against Cryptosporidium parvum.
The Journal of infectious diseases 2009;199(8):1195-204.
2009: Marie C Hogan; Luca Manganelli; John R Woollard; Anatoliy I Masyuk; Tatyana V Masyuk; Rachaneekorn Tammachote; Bing Q Huang; Alexey A Leontovich; Thomas G Beito; Benjamin J Madden; M Cristine Charlesworth; Vicente E Torres; Nicholas F LaRusso; Peter C Harris; Christopher J Ward
Characterization of PKD protein-positive exosome-like vesicles.
Journal of the American Society of Nephrology : JASN 2009;20(2):278-88.
2009: Ai-Yu Gong; Rui Zhou; Guoku Hu; Xiaoqing Li; Patrick L Splinter; Steven P O'Hara; Nicholas F LaRusso; garrett soukup; Haidong Dong; Xian-Ming Chen
MicroRNA-513 regulates B7-H1 translation and is involved in IFN-gamma-induced B7-H1 expression in cholangiocytes.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(3):1325-33.
2009: Michael D Brennan; Alan K Duncan; Ryan R Armbruster; victor montori; Wayne L Feyereisn; Nicholas F LaRusso
The application of design principles to innovate clinical care delivery.
Journal for healthcare quality : official publication of the National Association for Healthcare Quality 2009;31(1):5-9.
2009: Jesús M Banales; Tatyana V Masyuk; Sergio A Gradilone; Anatoliy I Masyuk; Juan F Medina; Nicholas F LaRusso
The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD).
Hepatology (Baltimore, Md.) 2009;49(1):160-74.
2009: Steven P O'Hara; Justin L Mott; Patrick L Splinter; Gregory J Gores; Nicholas F LaRusso
MicroRNAs: key modulators of posttranscriptional gene expression.
Gastroenterology 2009;136(1):17-25.
2008: Liselotte N Dyrbye; Keith D Lindor; Nicholas F LaRusso; David A Cook
Research productivity of graduates from 3 physician-scientist training programs.
The American journal of medicine 2008;121(12):1107-13.
2008: Jesús M Banales; Tatyana V Masyuk; Pamela S Bogert; Bing Q Huang; Sergio A Gradilone; Seung-Ok Lee; Angela J Stroope; Anatoliy I Masyuk; Juan F Medina; Nicholas F LaRusso
Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease.
The American journal of pathology 2008;173(6):1637-46.
2008: Alphonse E Sirica; Michael H Nathanson; Gregory J Gores; Nicholas F LaRusso
Pathobiology of biliary epithelia and cholangiocarcinoma: proceedings of the Henry M. and Lillian Stratton Basic Research Single-Topic Conference.
Hepatology (Baltimore, Md.) 2008;48(6):2040-6.
2008: Douglas L Wood; Michael D Brennan; Rajeev Chaudhry; Anthony A Chihak; Wayne L Feyereisn; Naomi L Woychick; Philip T Hagen; Jonathan W Curtright; James M Naessens; Barbara R Spurrier; Nicholas F LaRusso
Standardized care processes to improve quality and safety of patient care in a large academic practice: the Plummer Project of the Department of Medicine, Mayo Clinic.
Health services management research : an official journal of the Association of University Programs in Health Administration / HSMC, AUPHA 2008;21(4):276-80.
2008: Julia J Liu; Jonathan N Glickman; Anatoliy I Masyuk; Nicholas F LaRusso
Cholangiocyte bile salt transporters in cholesterol gallstone-susceptible and resistant inbred mouse strains.
Journal of gastroenterology and hepatology 2008;23(10):1596-602.
2008: Anatoliy I Masyuk; Sergio A Gradilone; Jesus M Banales; Bing Q Huang; Tatyana V Masyuk; Seung-Ok Lee; Patrick L Splinter; Angela J Stroope; Nicholas F LaRusso
Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors.
American journal of physiology. Gastrointestinal and liver physiology 2008;295(4):G725-34.
2008: Xian-Ming Chen; Steven P O'Hara; Nicholas F LaRusso
The immunobiology of cholangiocytes.
Immunology and cell biology 2008;86(6):497-505.
2008: Anatoliy I Masyuk; Tatyana V Masyuk; Nicholas F LaRusso
Cholangiocyte primary cilia in liver health and disease.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(8):2007-12.
2008: Steven P O'Hara; Aaron J Small; Xian-Ming Chen; Nicholas F LaRusso
Host cell actin remodeling in response to Cryptosporidium.
Sub-cellular biochemistry 2008;47():92-100.
2007: Sergio A Gradilone; Anatoliy I Masyuk; Patrick L Splinter; Jesus M Banales; Bing Q Huang; Pamela S Tietz; Tatyana V Masyuk; Nicholas F LaRusso
Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(48):19138-43.
2007: Noritaka Minagawa; Jun Nagata; Kazunori Shibao; Anatoliy I Masyuk; Dawidson Gomes; Michele Rodrigues; Gene Lesage; Yasutada Akiba; Jonathan D Kaunitz; Barbara E Ehrlich; Nicholas F LaRusso; Michael H Nathanson
Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile.
Gastroenterology 2007;133(5):1592-602.
2007: Xian-Ming Chen; Patrick L Splinter; Steven P O'Hara; Nicholas F LaRusso
A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection.
The Journal of biological chemistry 2007;282(39):28929-38.
2007: J R Woollard; R Punyashtiti; S Richardson; Tatyana V Masyuk; Shelly Whelan; Bing Q Huang; Donna J Lager; J vanDeursen; Vicente E Torres; Vincent H Gattone; Nicholas F LaRusso; Peter C Harris; Christopher J Ward
A mouse model of autosomal recessive polycystic kidney disease with biliary duct and proximal tubule dilatation.
Kidney international 2007;72(3):328-36.
2007: Pamela Tietz Bogert; Nicholas F LaRusso
Cholangiocyte biology.
Current opinion in gastroenterology 2007;23(3):299-305.
2007: Tatyana V Masyuk; Anatoliy I Masyuk; Vicente E Torres; Peter C Harris; Nicholas F LaRusso
Octreotide inhibits hepatic cystogenesis in a rodent model of polycystic liver disease by reducing cholangiocyte adenosine 3',5'-cyclic monophosphate.
Gastroenterology 2007;132(3):1104-16.
2007: Apinya Leerapun; Sri V Suravarapu; John P Bida; Raynell J Clark; Elizabeth L Sanders; Teresa A Mettler; Linda M Stadheim; Ileana Aderca; Catherine D Moser; David M Nagorney; Nicholas F LaRusso; Piet C de Groen; K V Narayanan Menon; Konstantinos N Lazaridis; Gregory J Gores; Michael R Charlton; Rosebud O Roberts; Terry M Therneau; Jerry A Katzmann; Lewis Roberts
The utility of Lens culinaris agglutinin-reactive alpha-fetoprotein in the diagnosis of hepatocellular carcinoma: evaluation in a United States referral population.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2007;5(3):394-402; quiz 267.
2007: Steven P O'Hara; Aaron J Small; Jeremy B Nelson; andrew badley; Xian-Ming Chen; Gregory J Gores; Nicholas F LaRusso
The human immunodeficiency virus type 1 tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism.
Infection and immunity 2007;75(2):684-96.
2007: Colin M Segovis; Paul S Mueller; Melissa Rethlefsen; Nicholas F LaRusso; Scott C Litin; Ayalew Tefferi; Thomas M Habermann
If you feed them, they will come: a prospective study of the effects of complimentary food on attendance and physician attitudes at medical grand rounds at an academic medical center.
BMC medical education 2007;7():22.
2006: Jorge Allina; Bin Hu; Daniel M Sullivan; M Isabel Fiel; Swan N Thung; Steven F Bronk; Robert C Huebert; Judith A van de Water; Nicholas F LaRusso; M Eric Gershwin; Gregory J Gores; Joseph A Odin
T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis.
Journal of autoimmunity 2006;27(4):232-41.
2006: Boris Blechacz; Patrick L Splinter; Suzanne Greiner; Rae Myers; Kah-Whye Peng; Mark J Federspiel; stephen russell; Nicholas F LaRusso
Engineered measles virus as a novel oncolytic viral therapy system for hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2006;44(6):1465-77.
2006: Jeremy B Nelson; Steven P O'Hara; Aaron J Small; Pamela S Tietz; Amit Choudhury; Richard E Pagano; Xian-Ming Chen; Nicholas F LaRusso
Cryptosporidium parvum infects human cholangiocytes via sphingolipid-enriched membrane microdomains.
Cellular microbiology 2006;8(12):1932-45.
2006: Patrick L Splinter; Konstantinos-N Lazaridis; Paul-A Dawson; Nicholas F LaRusso
Cloning and expression of SLC10A4, a putative organic anion transport protein.
World journal of gastroenterology : WJG 2006;12(42):6797-805.
2006: Thomas Hiesberger; Eric Gourley; Andrea Erickson; Peter Koulen; Christopher J Ward; Tatyana V Masyuk; Nicholas F LaRusso; Peter C Harris; Peter Igarashi
Proteolytic cleavage and nuclear translocation of fibrocystin is regulated by intracellular Ca2+ and activation of protein kinase C.
The Journal of biological chemistry 2006;281(45):34357-64.
2006: Anatoliy I Masyuk; Tatyana V Masyuk; Patrick L Splinter; Bing Q Huang; Angela J Stroope; Nicholas F LaRusso
Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling.
Gastroenterology 2006;131(3):911-20.
2006: Nicholas F LaRusso; Benjamin L Shneider; Dennis Black; Gregory J Gores; Stephen P James; Edward Doo; Jay H Hoofnagle
Primary sclerosing cholangitis: summary of a workshop.
Hepatology (Baltimore, Md.) 2006;44(3):746-64.
2006: Bing Q Huang; Tatyana V Masyuk; Melissa A Muff; Pamela S Tietz; Anatoliy I Masyuk; Nicholas F LaRusso
Isolation and characterization of cholangiocyte primary cilia.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(3):G500-9.
2006: Melissa A Muff; Tatyana V Masyuk; Angela J Stroope; Bing Q Huang; Patrick L Splinter; Seung-Ok Lee; Nicholas F LaRusso
Development and characterization of a cholangiocyte cell line from the PCK rat, an animal model of Autosomal Recessive Polycystic Kidney Disease.
Laboratory investigation; a journal of technical methods and pathology 2006;86(9):940-50.
2006: Meral Gunay-Aygun; Ellis D Avner; Robert L Bacallao; Peter L Choyke; Joseph T Flynn; Gregory G Germino; Lisa M Guay-Woodford; Peter Harris; Theo Heller; Julie R Ingelfinger; Frederick J Kaskel; Robert Kleta; Nicholas F LaRusso; Parvathi Mohan; Gregory Pazour; Benjamin L Shneider; Vicente E Torres; Patricia Wilson; Colleen Zak; Jing Zhou; William A Gahl
Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: summary statement of a first National Institutes of Health/Office of Rare Diseases conference.
The Journal of pediatrics 2006;149(2):159-64.
2006: Pamela S Tietz; Nicholas F LaRusso
Cholangiocyte biology.
Current opinion in gastroenterology 2006;22(3):279-87.
2006: Anatoliy I Masyuk; Nicholas F LaRusso
Aquaporins in the hepatobiliary system.
Hepatology (Baltimore, Md.) 2006;43(2 Suppl 1):S75-81.
2006: Amelia Mazzone; Pamela S Tietz; John Jefferson; Richard E Pagano; Nicholas F LaRusso
Isolation and characterization of lipid microdomains from apical and basolateral plasma membranes of rat hepatocytes.
Hepatology (Baltimore, Md.) 2006;43(2):287-96.
2006: Pamela S Tietz; Mark A McNiven; Patrick L Splinter; Bing Q Huang; Nicholas F LaRusso
Cytoskeletal and motor proteins facilitate trafficking of AQP1-containing vesicles in cholangiocytes.
Biology of the cell / under the auspices of the European Cell Biology Organization 2006;98(1):43-52.
2005: Xian-Ming Chen; Steven P O'Hara; Jeremy B Nelson; Patrick L Splinter; Aaron J Small; Pamela S Tietz; Andrew H Limper; Nicholas F LaRusso
Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappaB.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7447-56.
2005: Steven P O'Hara; Bing Q Huang; Xian-Ming Chen; Jeremy Nelson; Nicholas F LaRusso
Distribution of Cryptosporidium parvum sporozoite apical organelles during attachment to and internalization by cultured biliary epithelial cells.
The Journal of parasitology 2005;91(5):995-9.
2005: Umberto Laforenza; Emanuela Cova; Giulia Gastaldi; Simona Tritto; Monica Grazioli; Nicholas F LaRusso; Patrick L Splinter; Patrizia D'Adamo; Marisa Tosco; Ulderico Ventura
Aquaporin-8 is involved in water transport in isolated superficial colonocytes from rat proximal colon.
The Journal of nutrition 2005;135(10):2329-36.
2005: Richard J Keating; Nicholas F LaRusso; Joseph C Kolars
Perceived impact of duty hours limits on the fragmentation of patient care: results from an academic health center.
The American journal of medicine 2005;118(7):788-93.
2005: Pamela S Tietz; J Jefferson; Richard E Pagano; Nicholas F LaRusso
Membrane microdomains in hepatocytes: potential target areas for proteins involved in canalicular bile secretion.
Journal of lipid research 2005;46(7):1426-32.
2005: Xian-Ming Chen; Steven P O'Hara; Bing Q Huang; Patrick L Splinter; Jeremy B Nelson; Nicholas F LaRusso
Localized glucose and water influx facilitates Cryptosporidium parvum cellular invasion by means of modulation of host-cell membrane protrusion.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(18):6338-43.
2005: Pamela S Tietz; Nicholas F LaRusso
Cholangiocyte biology.
Current opinion in gastroenterology 2005;21(3):337-43.
2005: Raúl A Marinelli; Pamela S Tietz; Nicholas F LaRusso
Regulated vesicle trafficking of membrane transporters in hepatic epithelia.
Journal of hepatology 2005;42(4):592-603.
2005: Konstantinos N Lazaridis; Nicholas F LaRusso
Examining the increased IgM production and ursodeoxycholic acid treatment in PBC.
Gastroenterology 2005;128(2):498-500.
2005: Sergio A Gradilone; Pamela S Tietz; Patrick L Splinter; Raúl A Marinelli; Nicholas F LaRusso
Expression and subcellular localization of aquaporin water channels in the polarized hepatocyte cell line, WIF-B.
BMC physiology 2005;5():13.
2004: Xian-Ming Chen; Steven P O'Hara; Bing Q Huang; Jeremy B Nelson; Jim Jung-Ching Lin; Guan Zhu; Honorine D Ward; Nicholas F LaRusso
Apical organelle discharge by Cryptosporidium parvum is temperature, cytoskeleton, and intracellular calcium dependent and required for host cell invasion.
Infection and immunity 2004;72(12):6806-16.
2004: Konstantinos N Lazaridis; Mario Strazzabosco; Nicholas F LaRusso
The cholangiopathies: disorders of biliary epithelia.
Gastroenterology 2004;127(5):1565-77.
2004: Tatyana V Masyuk; Bing Q Huang; Anatoliy I Masyuk; Erik L Ritman; Vicente E Torres; Xiaofang Wang; Peter C Harris; Nicholas F LaRusso
Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease.
The American journal of pathology 2004;165(5):1719-30.
2004: Xian-Ming Chen; Patrick L Splinter; Pamela S Tietz; Bing Q Huang; Daniel D Billadeau; Nicholas F LaRusso
Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42.
The Journal of biological chemistry 2004;279(30):31671-8.
2004: N-Sertac Kip; Konstantinos-N Lazaridis; Anatoliy I Masyuk; Patrick L Splinter; Robert C Huebert; Nicholas F LaRusso
Differential expression of cholangiocyte and ileal bile acid transporters following bile acid supplementation and depletion.
World journal of gastroenterology : WJG 2004;10(10):1440-6.
2004: Pamela S Tietz; Nicholas F LaRusso
Cholangiocyte biology.
Current opinion in gastroenterology 2004;20(3):270-4.
2004: Xian-Ming Chen; Bing Q Huang; Patrick L Splinter; James Orth; Daniel D Billadeau; Mark A McNiven; Nicholas F LaRusso
Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum.
Infection and immunity 2004;72(5):3011-21.
2004: Bing Q Huang; Xian-Ming Chen; Nicholas F LaRusso
Cryptosporidium parvum attachment to and internalization by human biliary epithelia in vitro: a morphologic study.
The Journal of parasitology 2004;90(2):212-21.
2004: Patrick L Splinter; Anatoliy I Masyuk; Raúl A Marinelli; Nicholas F LaRusso
AQP4 transfected into mouse cholangiocytes promotes water transport in biliary epithelia.
Hepatology (Baltimore, Md.) 2004;39(1):109-16.
2003: Thomas B Crist; Nicholas F LaRusso; Frederick J Meyers; Charles P Clayton; Tod Ibrahim
Centers, institutes, and the future of clinical departments: Part II.
The American journal of medicine 2003;115(9):745-7.
2003: Tatyana V Masyuk; Bing Q Huang; Christopher J Ward; Anatoliy I Masyuk; David Yuan; Patrick L Splinter; Rachaneekorn Punyashthiti; Erik L Ritman; Vicente E Torres; Peter C Harris; Nicholas F LaRusso
Defects in cholangiocyte fibrocystin expression and ciliary structure in the PCK rat.
Gastroenterology 2003;125(5):1303-10.
2003: Raúl A Marinelli; Pamela S Tietz; Ariel J Caride; Bing Q Huang; Nicholas F LaRusso
Water transporting properties of hepatocyte basolateral and canalicular plasma membrane domains.
The Journal of biological chemistry 2003;278(44):43157-62.
2003: Christopher J Ward; David Yuan; Tatyana V Masyuk; Xiaofang Wang; Rachaneekorn Punyashthiti; Shelly Whelan; Robert L Bacallao; Roser Torra; Nicholas F LaRusso; Vicente E Torres; Peter C Harris
Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia.
Human molecular genetics 2003;12(20):2703-10.
2003: Tod Ibrahim; John B O'Connell; Nicholas F LaRusso; Frederick J Meyers; Thomas B Crist
Centers, Institutes, and the future of clinical departments: part I.
The American journal of medicine 2003;115(4):337-41.
2003: Xian-Ming Chen; Bing Q Huang; Patrick L Splinter; Hong Cao; Guan Zhu; Mark A McNiven; Nicholas F LaRusso
Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src.
Gastroenterology 2003;125(1):216-28.
2003: Sergio A Gradilone; Fabiana García; Robert C Huebert; Pamela S Tietz; M Cecilia Larocca; Arlinet Kierbel; Flavia I Carreras; Nicholas F LaRusso; Raúl A Marinelli
Glucagon induces the plasma membrane insertion of functional aquaporin-8 water channels in isolated rat hepatocytes.
Hepatology (Baltimore, Md.) 2003;37(6):1435-41.
2003: Pamela S Tietz; Raúl A Marinelli; Xian-Ming Chen; Bing Huang; Jonathan Cohn; Jolanta Kole; Mark A McNiven; Seth Alper; Nicholas F LaRusso
Agonist-induced coordinated trafficking of functionally related transport proteins for water and ions in cholangiocytes.
The Journal of biological chemistry 2003;278(22):20413-9.
2003: Pamela Tietz; Nicholas F LaRusso
Cholangiocyte biology.
Current opinion in gastroenterology 2003;19(3):264-9.
2003: Paul S Mueller; Scott C Litin; Monica L Sowden; Thomas M Habermann; Nicholas F LaRusso
Strategies for improving attendance at medical grand rounds at an academic medical center.
Mayo Clinic proceedings. Mayo Clinic 2003;78(5):549-53.
2003: Flavia I Carreras; Sergio A Gradilone; Amelia Mazzone; Fabiana García; Bing Q Huang; J Elena Ochoa; Pamela S Tietz; Nicholas F LaRusso; Giuseppe Calamita; Raúl A Marinelli
Rat hepatocyte aquaporin-8 water channels are down-regulated in extrahepatic cholestasis.
Hepatology (Baltimore, Md.) 2003;37(5):1026-33.
2003: Ai-Yu Gong; Pamela S Tietz; Melissa A Muff; Patrick L Splinter; Robert C Huebert; Mathias Z Strowski; Xian-Ming Chen; Nicholas F LaRusso
Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes.
American journal of physiology. Cell physiology 2003;284(5):C1205-14.
2003: Tatyana V Masyuk; Erik L Ritman; Nicholas F LaRusso
Hepatic artery and portal vein remodeling in rat liver: vascular response to selective cholangiocyte proliferation.
The American journal of pathology 2003;162(4):1175-82.
2003: Carlo Spirlì; Luca Fabris; Elena Duner; Romina Fiorotto; Giorgio Ballardini; Tania Roskams; Nicholas F LaRusso; Aurelio Sonzogni; Lajos Okolicsanyi; Mario Strazzabosco
Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes.
Gastroenterology 2003;124(3):737-53.
2003: Patrick L Splinter; Anatoliy I Masyuk; Nicholas F LaRusso
Specific inhibition of AQP1 water channels in isolated rat intrahepatic bile duct units by small interfering RNAs.
The Journal of biological chemistry 2003;278(8):6268-74.
2003: Konstantinos N Lazaridis; Nicholas F LaRusso
Bile formation: do not ignore the role of plasma membrane-cytoskeleton linking proteins.
Hepatology (Baltimore, Md.) 2003;37(1):218-20.
2002: Terry L Brandt; Clifford R Romme; Nicholas F LaRusso; Keith D Lindor
A novel incentive system for faculty in an academic medical center.
Annals of internal medicine 2002;137(9):738-43.
2002: Peter L Elkin; Barb Sorensen; Diane De Palo; Greg Poland; kent bailey; Douglas L Wood; Nicholas F LaRusso
Optimization of a research web environment for academic internal medicine faculty.
Journal of the American Medical Informatics Association : JAMIA 2002;9(5):472-8.
2002: Anatoliy I Masyuk; Tatyana V Masyuk; Pamela S Tietz; Patrick L Splinter; Nicholas F LaRusso
Intrahepatic bile ducts transport water in response to absorbed glucose.
American journal of physiology. Cell physiology 2002;283(3):C785-91.
2002: Xian-Ming Chen; Nicholas F LaRusso
Cryptosporidiosis and the pathogenesis of AIDS-cholangiopathy.
Seminars in liver disease 2002;22(3):277-89.
2002: Keiji Hirata; Jean-François Dufour; Kazunori Shibao; Roy Knickelbein; Allison F O'Neill; Hans-Peter Bode; Doris Cassio; Marie V St Pierre; Nicholas F LaRusso; M Fatima Leite; Michael H Nathanson
Regulation of Ca(2+) signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoforms.
Hepatology (Baltimore, Md.) 2002;36(2):284-96.
2002: Ai-Yu Gong; Anatoliy I Masyuk; Patrick L Splinter; Robert C Huebert; Pamela S Tietz; Nicholas F LaRusso
Channel-mediated water movement across enclosed or perfused mouse intrahepatic bile duct units.
American journal of physiology. Cell physiology 2002;283(1):C338-46.
2002: Robert C Huebert; Patrick L Splinter; Fabiana Garcia; Raúl A Marinelli; Nicholas F LaRusso
Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion.
The Journal of biological chemistry 2002;277(25):22710-7.
2002: Xian-Ming Chen; Janet S Keithly; Carlos V Paya; Nicholas F LaRusso
Cryptosporidiosis.
The New England journal of medicine 2002;346(22):1723-31.
2002: Pamela Tietz; Nicholas F LaRusso
Cholangiocyte biology.
Current opinion in gastroenterology 2002;18(3):360-5.
2002: Daniel C Buckles; Keith D Lindor; Nicholas F LaRusso; Lydia M Petrovic; Gregory J Gores
In primary sclerosing cholangitis, gallbladder polyps are frequently malignant.
The American journal of gastroenterology 2002;97(5):1138-42.
2002: Furman S McDonald; Henry J Schultz; Nicholas F LaRusso
A learner-centered academic career development curriculum.
Academic medicine : journal of the Association of American Medical Colleges 2002;77(5):463.
2002: Gianfranco Alpini; James M McGill; Nicholas F LaRusso
The pathobiology of biliary epithelia.
Hepatology (Baltimore, Md.) 2002;35(5):1256-68.
2002: Pamela S Tietz; Nicholas F LaRusso
Focus on "Cholangiocytes exhibit dynamic, actin-dependent apical membrane turnover".
American journal of physiology. Cell physiology 2002;282(5):C982-3.
2002: Pamela S Tietz; Xian-Ming Chen; Ai-Yu Gong; Robert C Huebert; Anatoliy I Masyuk; Tatyana V Masyuk; Patrick L Splinter; Nicholas F LaRusso
Experimental models to study cholangiocyte biology.
World journal of gastroenterology : WJG 2002;8(1):1-4.
2002: Anatoliy I Masyuk; Raúl A Marinelli; Nicholas F LaRusso
Water transport by epithelia of the digestive tract.
Gastroenterology 2002;122(2):545-62.
2001: Jonathan A Dranoff; Anatoliy I Masyuk; Emma A Kruglov; Nicholas F LaRusso; Michael H Nathanson
Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(4):G1059-67.
2001: E Cova; Ai-Yu Gong; Raúl A Marinelli; Nicholas F LaRusso
Water movement across rat bile duct units is transcellular and channel-mediated.
Hepatology (Baltimore, Md.) 2001;34(3):456-63.
2001: M Jaiswal; Nicholas F LaRusso; Gregory J Gores
Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(3):G626-34.
2001: Michael H Nathanson; Angela D Burgstahler; Anatoliy I Masyuk; Nicholas F LaRusso
Stimulation of ATP secretion in the liver by therapeutic bile acids.
The Biochemical journal 2001;358(Pt 1):1-5.
2001: Joseph A Odin; R C Huebert; Livia Casciola-Rosen; Nicholas F LaRusso; Antony Rosen
Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis.
The Journal of clinical investigation 2001;108(2):223-32.
2001: Tatyana V Masyuk; Erik L Ritman; Nicholas F LaRusso
Quantitative assessment of the rat intrahepatic biliary system by three-dimensional reconstruction.
The American journal of pathology 2001;158(6):2079-88.
2001: Xian-Ming Chen; S A Levine; Patrick L Splinter; Pamela S Tietz; A L Ganong; Christian Jobin; Gregory J Gores; Carlos V Paya; Nicholas F LaRusso
Cryptosporidium parvum activates nuclear factor kappaB in biliary epithelia preventing epithelial cell apoptosis.
Gastroenterology 2001;120(7):1774-83.
2001: Denise M Harnois; Paul Angulo; Roberta Jorgensen; Nicholas F LaRusso; Keith D Lindor
High-dose ursodeoxycholic acid as a therapy for patients with primary sclerosing cholangitis.
The American journal of gastroenterology 2001;96(5):1558-62.
2001: Fabiana García; Arlinet Kierbel; M Cecilia Larocca; Sergio A Gradilone; Patrick L Splinter; Nicholas F LaRusso; Raúl A Marinelli
The water channel aquaporin-8 is mainly intracellular in rat hepatocytes, and its plasma membrane insertion is stimulated by cyclic AMP.
The Journal of biological chemistry 2001;276(15):12147-52.
2001: Pamela S Tietz; Elizabeth M Hadac; Laurence J Miller; Nicholas F LaRusso
Upregulation of secretin receptors on cholangiocytes after bile duct ligation.
Regulatory peptides 2001;97(1):1-6.
2001: M Jaiswal; Nicholas F LaRusso; R A Shapiro; T R Billiar; Gregory J Gores
Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes.
Gastroenterology 2001;120(1):190-9.
2000: Anatoliy I Masyuk; Ai-Yu Gong; S Kip; M J Burke; Nicholas F LaRusso
Perfused rat intrahepatic bile ducts secrete and absorb water, solute, and ions.
Gastroenterology 2000;119(6):1672-80.
2000: Paul Angulo; D H Pearce; C Daniel Johnson; J J Henry; Nicholas F LaRusso; Bret T Petersen; Keith D Lindor
Magnetic resonance cholangiography in patients with biliary disease: its role in primary sclerosing cholangitis.
Journal of hepatology 2000;33(4):520-7.
2000: Konstantinos-N Lazaridis; Pamela S Tietz; T Wu; S Kip; Paul-A Dawson; Nicholas F LaRusso
Alternative splicing of the rat sodium/bile acid transporter changes its cellular localization and transport properties.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):11092-7.
2000: R T Prall; Nicholas F LaRusso
Biliary tract physiology.
Current opinion in gastroenterology 2000;16(5):432-6.
2000: W Ray Kim; Terry M Therneau; Russell H Wiesner; John J Poterucha; Joanne T Benson; Michael Malinchoc; Nicholas F LaRusso; Keith D Lindor; E Rolland Dickson
A revised natural history model for primary sclerosing cholangitis.
Mayo Clinic proceedings. Mayo Clinic 2000;75(7):688-94.
2000: Raúl A Marinelli; LD Pham; Pamela S Tietz; Nicholas F LaRusso
Expression of aquaporin-4 water channels in rat cholangiocytes.
Hepatology (Baltimore, Md.) 2000;31(6):1313-7.
2000: Xian-Ming Chen; Nicholas F LaRusso
Mechanisms of attachment and internalization of Cryptosporidium parvum to biliary and intestinal epithelial cells.
Gastroenterology 2000;118(2):368-79.
2000: M Jaiswal; Nicholas F LaRusso; L J Burgart; Gregory J Gores
Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism.
Cancer research 2000;60(1):184-90.
1999: Florencia G Que; V A Phan; V H Phan; A Celli; K Batts; Nicholas F LaRusso; Gregory J Gores
Cholangiocarcinomas express Fas ligand and disable the Fas receptor.
Hepatology (Baltimore, Md.) 1999;30(6):1398-404.
1999: Paul Angulo; D R Larson; Terry M Therneau; Nicholas F LaRusso; Kenneth P Batts; Keith D Lindor
Time course of histological progression in primary sclerosing cholangitis.
The American journal of gastroenterology 1999;94(11):3310-3.
1999: Ivo W Graziadei; Russell H Wiesner; Paul J Marotta; Michael K Porayko; J Eileen Hay; Michael R Charlton; John J Poterucha; Charles B Rosen; G J Gores; Nicholas F LaRusso; Ruud A F Krom
Long-term results of patients undergoing liver transplantation for primary sclerosing cholangitis.
Hepatology (Baltimore, Md.) 1999;30(5):1121-7.
1999: R T Prall; Nicholas F LaRusso
Biliary tract physiology.
Current opinion in gastroenterology 1999;15(5):423-9.
1999: Xian-Ming Chen; Gregory J Gores; Carlos V Paya; Nicholas F LaRusso
Cryptosporidium parvum induces apoptosis in biliary epithelia by a Fas/Fas ligand-dependent mechanism.
The American journal of physiology 1999;277(3 Pt 1):G599-608.
1999: W Ray Kim; John J Poterucha; Russell H Wiesner; Nicholas F LaRusso; Keith D Lindor; Janice L Petz; Terry M Therneau; Michael Malinchoc; E Rolland Dickson
The relative role of the Child-Pugh classification and the Mayo natural history model in the assessment of survival in patients with primary sclerosing cholangitis.
Hepatology (Baltimore, Md.) 1999;29(6):1643-8.
1999: Florencia G Que; V A Phan; V H Phan; Nicholas F LaRusso; Gregory J Gores
GUDC inhibits cytochrome c release from human cholangiocyte mitochondria.
The Journal of surgical research 1999;83(2):100-5.
1999: Ivo W Graziadei; Russell H Wiesner; Kenneth P Batts; Paul J Marotta; Nicholas F LaRusso; Michael K Porayko; J Eileen Hay; G J Gores; Michael R Charlton; J Ludwig; John J Poterucha; Jeffery L Steers; Ruud A F Krom
Recurrence of primary sclerosing cholangitis following liver transplantation.
Hepatology (Baltimore, Md.) 1999;29(4):1050-6.
1999: Nicholas F LaRusso
The Fifth Carlos E. Rubio Memorial Lecture. Sclerosing cholangitis: pathogenesis, pathology, and practice.
Puerto Rico health sciences journal 1999;18(1):11-7.
1999: Paul Angulo; A E Bharucha; Roberta Jorgensen; CK DeSotel; William J Sandborn; Nicholas F LaRusso; Keith D Lindor
Oral nicotine in treatment of primary sclerosing cholangitis: a pilot study.
Digestive diseases and sciences 1999;44(3):602-7.
1999: Raúl A Marinelli; Pamela S Tietz; LD Pham; L Rueckert; Peter Agre; Nicholas F LaRusso
Secretin induces the apical insertion of aquaporin-1 water channels in rat cholangiocytes.
The American journal of physiology 1999;276(1 Pt 1):G280-6.
1998: Carlo Spirlì; Anna Granato; K Zsembery; Franca Anglani; L Okolicsányi; Nicholas F LaRusso; Gaetano Crepaldi; Mario Strazzabosco
Functional polarity of Na+/H+ and Cl-/HCO3- exchangers in a rat cholangiocyte cell line.
The American journal of physiology 1998;275(6 Pt 1):G1236-45.
1998: Piet C de Groen; B Vroman; K Laakso; Nicholas F LaRusso
Characterization and growth regulation of a rat intrahepatic bile duct epithelial cell line under hormonally defined, serum-free conditions.
In vitro cellular & developmental biology. Animal 1998;34(9):704-10.
1998: A Celli; Florencia G Que; Gregory J Gores; Nicholas F LaRusso
Glutathione depletion is associated with decreased Bcl-2 expression and increased apoptosis in cholangiocytes.
The American journal of physiology 1998;275(4 Pt 1):G749-57.
1998: Ákos Zsembery; Carlo Spirlì; Anna Granato; Nicholas F LaRusso; Lajos Okolicsanyi; Gaetano Crepaldi; Mario Strazzabosco
Purinergic regulation of acid/base transport in human and rat biliary epithelial cell lines.
Hepatology (Baltimore, Md.) 1998;28(4):914-20.
1998: Xian-Ming Chen; S A Levine; Pamela S Tietz; Eugene W Krueger; Mark A McNiven; D M Jefferson; M Mahle; Nicholas F LaRusso
Cryptosporidium parvum is cytopathic for cultured human biliary epithelia via an apoptotic mechanism.
Hepatology (Baltimore, Md.) 1998;28(4):906-13.
1998: J Ludwig; Erik L Ritman; Nicholas F LaRusso; P F Sheedy; G Zumpe
Anatomy of the human biliary system studied by quantitative computer-aided three-dimensional imaging techniques.
Hepatology (Baltimore, Md.) 1998;27(4):893-9.
1997: Pamela S Tietz; S Levine; R Holman; C Fretham; Nicholas F LaRusso
Characterization of apical and basolateral plasma membrane domains derived from cultured rat cholangiocytes.
Analytical biochemistry 1997;254(2):192-9.
1997: Konstantinos-N Lazaridis; LD Pham; Pamela S Tietz; Raúl A Marinelli; P C deGroen; S Levine; Paul-A Dawson; Nicholas F LaRusso
Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter.
The Journal of clinical investigation 1997;100(11):2714-21.
1997: Raúl A Marinelli; Nicholas F LaRusso
Aquaporin water channels in liver: their significance in bile formation.
Hepatology (Baltimore, Md.) 1997;26(5):1081-4.
1997: D M Harnois; Florencia G Que; A Celli; Nicholas F LaRusso; Gregory J Gores
Bcl-2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell line.
Hepatology (Baltimore, Md.) 1997;26(4):884-90.
1997: Denise M Harnois; Gregory J Gores; J Ludwig; Jeffery L Steers; Nicholas F LaRusso; Russell H Wiesner
Are patients with cirrhotic stage primary sclerosing cholangitis at risk for the development of hepatocellular cancer?
Journal of hepatology 1997;27(3):512-6.
1997: Raúl A Marinelli; LD Pham; Peter Agre; Nicholas F LaRusso
Secretin promotes osmotic water transport in rat cholangiocytes by increasing aquaporin-1 water channels in plasma membrane. Evidence for a secretin-induced vesicular translocation of aquaporin-1.
The Journal of biological chemistry 1997;272(20):12984-8.
1997: Konstantinos-N Lazaridis; LD Pham; B Vroman; Piet C de Groen; Nicholas F LaRusso
Kinetic and molecular identification of sodium-dependent glucose transporter in normal rat cholangiocytes.
The American journal of physiology 1997;272(5 Pt 1):G1168-74.
1997: G Alpini; C Ulrich; S Roberts; J O Phillips; Yoshiyuki Ueno; P V Podila; O Colegio; Gene Lesage; Laurence J Miller; Nicholas F LaRusso
Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation.
The American journal of physiology 1997;272(2 Pt 1):G289-97.
1997: Florencia G Que; Gregory J Gores; Nicholas F LaRusso
Development and initial application of an in vitro model of apoptosis in rodent cholangiocytes.
The American journal of physiology 1997;272(1 Pt 1):G106-15.
1997: S K Roberts; J Ludwig; Nicholas F LaRusso
The pathobiology of biliary epithelia.
Gastroenterology 1997;112(1):269-79.
1996: Russell H Wiesner; Michael K Porayko; J Eileen Hay; Nicholas F LaRusso; Jeffery L Steers; Ruud A F Krom; E R Dickson
Liver transplantation for primary sclerosing cholangitis: impact of risk factors on outcome.
Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 1996;2(5 Suppl 1):99-108.
1996: Raúl A Marinelli; Nicholas F LaRusso
Solute and water transport pathways in cholangiocytes.
Seminars in liver disease 1996;16(2):221-9.
1996: Gianfranco Alpini; S Roberts; S M Kuntz; Yoshiyuki Ueno; S Gubba; P V Podila; Gene Lesage; Nicholas F LaRusso
Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver.
Gastroenterology 1996;110(5):1636-43.
1996: M Yano; Raúl A Marinelli; S K Roberts; V Balan; LD Pham; J E Tarara; Piet C de Groen; Nicholas F LaRusso
Rat hepatocytes transport water mainly via a non-channel-mediated pathway.
The Journal of biological chemistry 1996;271(12):6702-7.
1996: Keith D Lindor; Roberta Jorgensen; M L Anderson; Gregory J Gores; A F Hofmann; Nicholas F LaRusso
Ursodeoxycholic acid and methotrexate for primary sclerosing cholangitis: a pilot study.
The American journal of gastroenterology 1996;91(3):511-5.
1996: C Penna; Roger R Dozois; William J Tremaine; William J Sandborn; Nicholas F LaRusso; C Schleck; D Ilstrup
Pouchitis after ileal pouch-anal anastomosis for ulcerative colitis occurs with increased frequency in patients with associated primary sclerosing cholangitis.
Gut 1996;38(2):234-9.
1996: Yoshiyuki Ueno; J O Phillips; J Ludwig; Steven N Lichtman; Nicholas F LaRusso
Development and characterization of a rodent model of immune-mediated cholangitis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):216-20.
1996: Nicholas F LaRusso
Morphology, physiology, and biochemistry of biliary epithelia.
Toxicologic pathology 1996;24(1):84-9.
1996: B Vroman; Nicholas F LaRusso
Development and characterization of polarized primary cultures of rat intrahepatic bile duct epithelial cells.
Laboratory investigation; a journal of technical methods and pathology 1996;74(1):303-13.
1995: Pamela S Tietz; R T Holman; Laurence J Miller; Nicholas F LaRusso
Isolation and characterization of rat cholangiocyte vesicles enriched in apical or basolateral plasma membrane domains.
Biochemistry 1995;34(47):15436-43.
1995: B M Myers; P S Tietz; J E Tarara; Nicholas F LaRusso
Dynamic measurements of the acute and chronic effects of lysosomotropic agents on hepatocyte lysosomal pH using flow cytometry.
Hepatology (Baltimore, Md.) 1995;22(5):1519-26.
1995: Pamela S Tietz; Gianfranco Alpini; LD Pham; Nicholas F LaRusso
Somatostatin inhibits secretin-induced ductal hypercholeresis and exocytosis by cholangiocytes.
The American journal of physiology 1995;269(1 Pt 1):G110-8.
1995: A Nakano; D L Marks; Pamela S Tietz; Piet C de Groen; Nicholas F LaRusso
Quantitative importance of biliary excretion to the turnover of hepatic lysosomal enzymes.
Hepatology (Baltimore, Md.) 1995;22(1):262-6.
1995: C K Tan; P V Podila; J E Taylor; D M Nagorney; G A Wiseman; Gregory J Gores; Nicholas F LaRusso
Human cholangiocarcinomas express somatostatin receptors and respond to somatostatin with growth inhibition.
Gastroenterology 1995;108(6):1908-16.
1995: R A Jorgensen; K D Lindor; J S Sartin; Nicholas F LaRusso; R H Wiesner
Serum lipid and fat-soluble vitamin levels in primary sclerosing cholangitis.
Journal of clinical gastroenterology 1995;20(3):215-9.
1995: D L Marks; Nicholas F LaRusso; Mark A McNiven
Isolation of the microtubule-vesicle motor kinesin from rat liver: selective inhibition by cholestatic bile acids.
Gastroenterology 1995;108(3):824-33.
1994: S K Roberts; M Yano; Yoshiyuki Ueno; LD Pham; Gianfranco Alpini; Peter Agre; Nicholas F LaRusso
Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):13009-13.
1994: Gianfranco Alpini; J O Phillips; B Vroman; Nicholas F LaRusso
Recent advances in the isolation of liver cells.
Hepatology (Baltimore, Md.) 1994;20(2):494-514.
1994: Yoshiyuki Ueno; Nicholas F LaRusso
Primary sclerosing cholangitis.
Journal of gastroenterology 1994;29(4):531-43.
1994: Gianfranco Alpini; Charles D Ulrich; J O Phillips; LD Pham; Laurence J Miller; Nicholas F LaRusso
Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation.
The American journal of physiology 1994;266(5 Pt 1):G922-8.
1994: R M Janas; D L Marks; Nicholas F LaRusso
Purification and partial characterization of a heat-resistant, cytosolic neuropeptidase from rat liver.
Biochemical and biophysical research communications 1994;198(2):574-81.
1993: B M Myers; F G Prendergast; R Holman; S M Kuntz; Nicholas F LaRusso
Alterations in hepatocyte lysosomes in experimental hepatic copper overload in rats.
Gastroenterology 1993;105(6):1814-23.
1993: S K Roberts; S M Kuntz; G J Gores; Nicholas F LaRusso
Regulation of bicarbonate-dependent ductular bile secretion assessed by lumenal micropuncture of isolated rodent intrahepatic bile ducts.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):9080-4.
1993: J C Nichols; Gregory J Gores; Nicholas F LaRusso; Russell H Wiesner; David M Nagorney; R E Ritts
Diagnostic role of serum CA 19-9 for cholangiocarcinoma in patients with primary sclerosing cholangitis.
Mayo Clinic proceedings. Mayo Clinic 1993;68(9):874-9.
1993: William J Sandborn; Russell H Wiesner; William J Tremaine; Nicholas F LaRusso
Ulcerative colitis disease activity following treatment of associated primary sclerosing cholangitis with cyclosporin.
Gut 1993;34(2):242-6.
1992: E Rolland Dickson; P A Murtaugh; Russell H Wiesner; P M Grambsch; T R Fleming; J Ludwig; Nicholas F LaRusso; Michael Malinchoc; R W Chapman; M M Kaplan
Primary sclerosing cholangitis: refinement and validation of survival models.
Gastroenterology 1992;103(6):1893-901.
1992: Russell H Wiesner; Michael K Porayko; E R Dickson; Gregory J Gores; Nicholas F LaRusso; J Eileen Hay; H E Wahlstrom; Ruud A F Krom
Selection and timing of liver transplantation in primary biliary cirrhosis and primary sclerosing cholangitis.
Hepatology (Baltimore, Md.) 1992;16(5):1290-9.
1992: R M Janas; D L Marks; Nicholas F LaRusso
An aluminum silicate binding assay for quantitation of degradation of cholecystokinin octapeptide and other short peptides.
Analytical biochemistry 1992;206(1):6-11.
1992: A Kato; Gregory J Gores; Nicholas F LaRusso
Secretin stimulates exocytosis in isolated bile duct epithelial cells by a cyclic AMP-mediated mechanism.
The Journal of biological chemistry 1992;267(22):15523-9.
1992: B J Hoerl; Ben Vroman; Jan L Kasperbauer; Nicholas F LaRusso; Robert E Scott
Biological characteristics of primary cultures of human gallbladder epithelial cells.
Laboratory investigation; a journal of technical methods and pathology 1992;66(2):243-50.
1991: B M Myers; F G Prendergast; R Holman; S M Kuntz; Nicholas F LaRusso
Alterations in the structure, physicochemical properties, and pH of hepatocyte lysosomes in experimental iron overload.
The Journal of clinical investigation 1991;88(4):1207-15.
1991: D L Marks; L J Kost; S M Kuntz; J Carlos Romero; Nicholas F LaRusso
Hepatic processing of recombinant human renin: mechanisms of uptake and degradation.
The American journal of physiology 1991;261(2 Pt 1):G349-58.
1991: Nicholas F LaRusso; M Ishii; B T Vroman
The ins and outs of membrane movement in biliary epithelia.
Transactions of the American Clinical and Climatological Association 1991;102():245-58; discussion 258-9.
1990: Pamela S Tietz; K Yamazaki; Nicholas F LaRusso
Time-dependent effects of chloroquine on pH of hepatocyte lysosomes.
Biochemical pharmacology 1990;40(6):1419-21.
1990: L J Kost; Gregory J Gores; J M Sayles; Laurence J Miller; John J Lemasters; Brian Herman; Nicholas F LaRusso
Lack of metabolic effects of cholecystokinin on hepatocytes.
Hepatology (Baltimore, Md.) 1990;12(2):301-5.
1990: E B Hunter; S P Powers; L J Kost; Delia I Pinon; Laurence J Miller; Nicholas F LaRusso
Physicochemical determinants in hepatic extraction of small peptides.
Hepatology (Baltimore, Md.) 1990;12(1):76-82.
1990: A Nakano; Pamela S Tietz; Nicholas F LaRusso
Circadian rhythms of biliary protein and lipid excretion in rats.
The American journal of physiology 1990;258(5 Pt 1):G653-9.
1990: M Ishii; B Vroman; Nicholas F LaRusso
Morphologic demonstration of receptor-mediated endocytosis of epidermal growth factor by isolated bile duct epithelial cells.
Gastroenterology 1990;98(5 Pt 1):1284-91.
1990: M Ishii; B Vroman; Nicholas F LaRusso
Fluid-phase endocytosis by intrahepatic bile duct epithelial cells isolated from normal rat liver.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1990;38(4):515-24.
1989: Piet C de Groen; G D LeSage; Pamela S Tietz; Nicholas F LaRusso
Purification and immunological quantification of rat liver lysosomal glycosidases.
The Biochemical journal 1989;264(1):115-23.
1989: M Ishii; B Vroman; Nicholas F LaRusso
Isolation and morphologic characterization of bile duct epithelial cells from normal rat liver.
Gastroenterology 1989;97(5):1236-47.
1989: K Yamazaki; Nicholas F LaRusso
The liver and intracellular digestion: how liver cells eat!
Hepatology (Baltimore, Md.) 1989;10(5):877-86.
1989: Gregory J Gores; L J Kost; Laurence J Miller; Nicholas F LaRusso
Processing of cholecystokinin by isolated liver cells.
The American journal of physiology 1989;257(2 Pt 1):G242-8.
1989: J B Gross; B M Myers; L J Kost; S M Kuntz; Nicholas F LaRusso
Biliary copper excretion by hepatocyte lysosomes in the rat. Major excretory pathway in experimental copper overload.
The Journal of clinical investigation 1989;83(1):30-9.
1988: K Balasubramaniam; Russell H Wiesner; Nicholas F LaRusso
Primary sclerosing cholangitis with normal serum alkaline phosphatase activity.
Gastroenterology 1988;95(5):1395-8.
1988: K Yamazaki; S P Powers; Nicholas F LaRusso
Biliary proteins: assessment of quantitative techniques and comparison in gallstone and nongallstone subjects.
Journal of lipid research 1988;29(8):1055-63.
1987: Keith D Lindor; Russell H Wiesner; Nicholas F LaRusso
Recent advances in the management of primary sclerosing cholangitis.
Seminars in liver disease 1987;7(4):322-7.
1987: J A Keiser; J Carlos Romero; L J Kost; Nicholas F LaRusso
Hepatic extraction of renin: quantitation and characterization in the isolated perfused rat liver.
Hepatology (Baltimore, Md.) 1987;7(6):1254-61.