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Lawrence Lash

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Bavneet Benipal; Lawrence H Lash
Modulation of mitochondrial glutathione status and cellular energetics in primary cultures of proximal tubular cells from remnant kidney of uninephrectomized rats.
Heather M Wilkins; Lawrence H Lash; Kristin Marquardt; Daniel A Linseman
Bcl-2 is a novel interacting partner for the 2-oxoglutarate carrier and a key regulator of mitochondrial glutathione.
David A Putt; Qing Zhong; Lawrence H Lash
Adaptive changes in renal mitochondrial redox status in diabetic nephropathy.

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All Publications

2013: Bavneet Benipal; Lawrence H Lash
Modulation of mitochondrial glutathione status and cellular energetics in primary cultures of proximal tubular cells from remnant kidney of uninephrectomized rats.
Biochemical pharmacology 2013;85(9):1379-88.
2012: Heather M Wilkins; Lawrence H Lash; Kristin Marquardt; Daniel A Linseman
Bcl-2 is a novel interacting partner for the 2-oxoglutarate carrier and a key regulator of mitochondrial glutathione.
Free radical biology & medicine 2012;52(2):410-9.
2012: David A Putt; Qing Zhong; Lawrence H Lash
Adaptive changes in renal mitochondrial redox status in diabetic nephropathy.
Toxicology and applied pharmacology 2012;258(2):188-98.
2011: Lawrence H Lash
Renal membrane transport of glutathione in toxicology and disease.
Veterinary pathology 2011;48(2):408-19.
2011: Bavneet Benipal; Lawrence H Lash
Influence of renal compensatory hypertrophy on mitochondrial energetics and redox status.
Biochemical pharmacology 2011;81(2):295-303.
2010: Devika Soundara Manickam; Jing Li; David A Putt; Qinghui Zhou; Chao Wu; Lawrence H Lash; David Oupický
Effect of innate glutathione levels on activity of redox-responsive gene delivery vectors.
Journal of controlled release : official journal of the Controlled Release Society 2010;141(1):77-84.
2009: Qing Zhong; Stanley R Terlecky; Lawrence H Lash
Diabetes increases susceptibility of primary cultures of rat proximal tubular cells to chemically induced injury.
Toxicology and applied pharmacology 2009;241(1):1-13.
2009: Lawrence H Lash
Renal glutathione transport: Identification of carriers, physiological functions, and controversies.
BioFactors (Oxford, England) 2009;35(6):500-8.
2009: Hongliang Cai; Arun K Agrawal; David A Putt; Muhammed Hashim; Anita Reddy; Joanne Brodfuehrer; Narayanan Surendran; Lawrence H Lash
Assessment of the renal toxicity of novel anti-inflammatory compounds using cynomolgus monkey and human kidney cells.
Toxicology 2009;258(1):56-63.
2008: Feng Xu; Irene Papanayotou; David A Putt; Jian Wang; Lawrence H Lash
Role of mitochondrial dysfunction in cellular responses to S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells.
Biochemical pharmacology 2008;76(4):552-67.
2008: Devika S Manickam; Aiko Hirata; David A Putt; Lawrence H Lash; Fusao Hirata; David Oupický
Overexpression of Bcl-2 as a proxy redox stimulus to enhance activity of non-viral redox-responsive delivery vectors.
Biomaterials 2008;29(17):2680-8.
2008: Qing Zhong; David A Putt; Feng Xu; Lawrence H Lash
Hepatic mitochondrial transport of glutathione: studies in isolated rat liver mitochondria and H4IIE rat hepatoma cells.
Archives of biochemistry and biophysics 2008;474(1):119-27.
2008: Keith M Erikson; David C Dorman; Lawrence H Lash; Michael Aschner
Duration of airborne-manganese exposure in rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity.
Neurotoxicology 2008;29(3):377-85.
2008: Lawrence H Lash
Epidermal growth factor receptor ligands and renal epithelial cell proliferation.
American journal of physiology. Renal physiology 2008;294(3):F457-8.
2008: Lawrence H Lash
Mitochondrial GSH transport and intestinal cell injury: a commentary on "Contribution of mitochondrial GSH transport to matrix GSH status and colonic epithelial cell apoptosis".
Free radical biology & medicine 2008;44(5):765-7.
2008: Lawrence H Lash; David A Putt; Hongliang Cai
Drug metabolism enzyme expression and activity in primary cultures of human proximal tubular cells.
Toxicology 2008;244(1):56-65.
2007: Lawrence H Lash; David A Putt; Feng Xu; Larry H Matherly
Role of rat organic anion transporter 3 (Oat3) in the renal basolateral transport of glutathione.
Chemico-biological interactions 2007;170(2):124-34.
2007: Lawrence H Lash
Methods for measuring cysteine S-conjugate β-lyase activity.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2007;Chapter 6():Unit6.13.
2007: Lawrence H Lash
Glutathione-dependent bioactivation.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2007;Chapter 6():Unit6.12.
2007: Lawrence H Lash; David A Putt; Sarah E Hueni; Scott G Payton; Joshua Zwickl
Interactive toxicity of inorganic mercury and trichloroethylene in rat and human proximal tubules: effects on apoptosis, necrosis, and glutathione status.
Toxicology and applied pharmacology 2007;221(3):349-62.
2007: Lawrence H Lash; David A Putt; Paul Huang; Sarah E Hueni; Jean C Parker
Modulation of hepatic and renal metabolism and toxicity of trichloroethylene and perchloroethylene by alterations in status of cytochrome P450 and glutathione.
Toxicology 2007;235(1-2):11-26.
2007: Keith M Erikson; David C Dorman; Lawrence H Lash; Michael Aschner
Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2007;97(2):459-66.
2006: Lawrence H Lash; David A Putt; Hongliang Cai
Membrane transport function in primary cultures of human proximal tubular cells.
Toxicology 2006;228(2-3):200-18.
2006: Lawrence H Lash; David A Putt; Rudolfs Zalups
Influence of compensatory renal growth on susceptibility of primary cultures of renal cells to chemically induced injury.
Toxicological sciences : an official journal of the Society of Toxicology 2006;94(2):417-27.
2006: Lawrence H Lash
Mitochondrial glutathione transport: physiological, pathological and toxicological implications.
Chemico-biological interactions 2006;163(1-2):54-67.
2006: Lawrence H Lash; David A Putt; Jean C Parker
Metabolism and tissue distribution of orally administered trichloroethylene in male and female rats: identification of glutathione- and cytochrome P-450-derived metabolites in liver, kidney, blood, and urine.
Journal of toxicology and environmental health. Part A 2006;69(13):1285-309.
2006: Rudolfs Zalups; Lawrence H Lash
Cystine alters the renal and hepatic disposition of inorganic mercury and plasma thiol status.
Toxicology and applied pharmacology 2006;214(1):88-97.
2006: Feng Xu; David A Putt; Larry H Matherly; Lawrence H Lash
Modulation of expression of rat mitochondrial 2-oxoglutarate carrier in NRK-52E cells alters mitochondrial transport and accumulation of glutathione and susceptibility to chemically induced apoptosis.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1175-86.
2006: Poh-Gek Forkert; Brandie Millen; Lawrence H Lash; David A Putt; Burhan I Ghanayem
Pulmonary bronchiolar cytotoxicity and formation of dichloroacetyl lysine protein adducts in mice treated with trichloroethylene.
The Journal of pharmacology and experimental therapeutics 2006;316(2):520-9.
2006: Keith M Erikson; David C Dorman; Vanessa A Fitsanakis; Lawrence H Lash; Michael Aschner
Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese.
Biological trace element research 2006;111(1-3):199-215.
2006: Ashley N Donahue; Michael Aschner; Lawrence H Lash; Tore Syversen; William E Sonntag
Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus.
Mechanisms of ageing and development 2006;127(1):57-63.
2005: Lawrence H Lash; Sarah E Hueni; David A Putt; Rudolfs Zalups
Role of organic anion and amino acid carriers in transport of inorganic mercury in rat renal basolateral membrane vesicles: influence of compensatory renal growth.
Toxicological sciences : an official journal of the Society of Toxicology 2005;88(2):630-44.
2005: Poh-Gek Forkert; R Michael Baldwin; Brandie Millen; Lawrence H Lash; David A Putt; Michael A Shultz; Kathy S Collins
Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(10):1429-37.
2005: Lawrence H Lash; David A Putt; Sarah E Hueni; Beth P Horwitz
Molecular markers of trichloroethylene-induced toxicity in human kidney cells.
Toxicology and applied pharmacology 2005;206(2):157-68.
2005: Keith M Erikson; David C Dorman; Lawrence H Lash; Michael Aschner
Persistent alterations in biomarkers of oxidative stress resulting from combined in utero and neonatal manganese inhalation.
Biological trace element research 2005;104(2):151-63.
2005: Lawrence H Lash
Role of glutathione transport processes in kidney function.
Toxicology and applied pharmacology 2005;204(3):329-42.
2004: Keith M Erikson; David C Dorman; Lawrence H Lash; Allison W Dobson; Michael Aschner
Airborne manganese exposure differentially affects end points of oxidative stress in an age- and sex-dependent manner.
Biological trace element research 2004;100(1):49-62.
2004: Denise L Stredrick; Alan H Stokes; Travis J Worst; Willard M Freeman; Elizabeth A Johnson; Lawrence H Lash; Michael Aschner; Kent Vrana
Manganese-induced cytotoxicity in dopamine-producing cells.
Neurotoxicology 2004;25(4):543-53.
2003: Lawrence H Lash
The mitochondrial benzodiazepine receptor as a potential target protein for drug development: demonstration of functional significance with cell lines exhibiting differential expression of Bcl-2.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(1):1-3.
2003: Lawrence H Lash; David A Putt; Sarah E Hueni; Renee J Krause; Adnan A Elfarra
Roles of necrosis, Apoptosis, and mitochondrial dysfunction in S-(1,2-dichlorovinyl)-L-cysteine sulfoxide-induced cytotoxicity in primary cultures of human renal proximal tubular cells.
The Journal of pharmacology and experimental therapeutics 2003;305(3):1163-72.
2003: Lawrence H Lash; Ronald Hines; Frank J Gonzalez; Timothy R Zacharewski; Mark A Rothstein
Genetics and susceptibility to toxic chemicals: do you (or should you) know your genetic profile?
The Journal of pharmacology and experimental therapeutics 2003;305(2):403-9.
2003: Poh-Gek Forkert; Lawrence H Lash; Robert Tardif; Nongnuj Tanphaichitr; Catherine A VandeVoort; Madeleine Moussa
Identification of trichloroethylene and its metabolites in human seminal fluid of workers exposed to trichloroethylene.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(3):306-11.
2003: Renee J Krause; Lawrence H Lash; Adnan A Elfarra
Human kidney flavin-containing monooxygenases and their potential roles in cysteine s-conjugate metabolism and nephrotoxicity.
The Journal of pharmacology and experimental therapeutics 2003;304(1):185-91.
2002: Lawrence H Lash; David A Putt; Sarah E Hueni; Wei Cao; Feng Xu; Stephen J Kulidjian; Judith P Horwitz
Cellular energetics and glutathione status in NRK-52E cells: toxicological implications.
Biochemical pharmacology 2002;64(10):1533-46.
2002: Lawrence H Lash; David A Putt; Larry H Matherly
Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter.
The Journal of pharmacology and experimental therapeutics 2002;303(2):476-86.
2002: Poh-Gek Forkert; Lawrence H Lash; Veronique Nadeau; Robert Tardif; Andrea C Simmonds
Metabolism and toxicity of trichloroethylene in epididymis and testis.
Toxicology and applied pharmacology 2002;182(3):244-54.
2002: Sarah Weber; David C Dorman; Lawrence H Lash; Keith M Erikson; Kent Vrana; Michael Aschner
Effects of manganese (Mn) on the developing rat brain: oxidative-stress related endpoints.
Neurotoxicology 2002;23(2):169-75.
2002: Lawrence H Lash; Wei Qian; David A Putt; Sarah E Hueni; Adnan A Elfarra; Anna Rita Sicuri; Jean C Parker
Renal toxicity of perchloroethylene and S-(1,2,2-trichlorovinyl)glutathione in rats and mice: sex- and species-dependent differences.
Toxicology and applied pharmacology 2002;179(3):163-71.
2001: Lawrence H Lash; Sarah E Hueni; David A Putt
Apoptosis, necrosis, and cell proliferation induced by S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells.
Toxicology and applied pharmacology 2001;177(1):1-16.
2001: Srinivasa Muralidhara; R Ramanathan; S M Mehta; Lawrence H Lash; D Acosta; James V Bruckner
Acute, subacute, and subchronic oral toxicity studies of 1,1-dichloroethane in rats: application to risk evaluation.
Toxicological sciences : an official journal of the Society of Toxicology 2001;64(1):135-45.
2001: Lawrence H Lash; David A Putt; S J Horky; Rudolfs Zalups
Functional and toxicological characteristics of isolated renal mitochondria: impact of compensatory renal growth.
Biochemical pharmacology 2001;62(3):383-95.
2001: Gary O Rankin; Suk K Hong; Dianne K Anestis; Lawrence H Lash; S L Miles
In vitro nephrotoxicity induced by N-(3,5-dichlorophenyl)succinimide (NDPS) metabolites in isolated renal cortical cells from male and female Fischer 344 rats: evidence for a nephrotoxic sulfate conjugate metabolite.
Toxicology 2001;163(2-3):73-82.
2001: Lawrence H Lash; Jean C Parker
Hepatic and renal toxicities associated with perchloroethylene.
Pharmacological reviews 2001;53(2):177-208.
2001: Lawrence H Lash; Wei Qian; David A Putt; Sarah E Hueni; Adnan A Elfarra; Renee J Krause; Jean C Parker
Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences.
The Journal of pharmacology and experimental therapeutics 2001;297(1):155-64.
2001: BS Cummings; Jean C Parker; Lawrence H Lash
Cytochrome p450-dependent metabolism of trichloroethylene in rat kidney.
Toxicological sciences : an official journal of the Society of Toxicology 2001;60(1):11-9.
2001: Lawrence H Lash; David A Putt; Rudolfs Zalups
Biochemical and functional characteristics of cultured renal epithelial cells from uninephrectomized rats: factors influencing nephrotoxicity.
The Journal of pharmacology and experimental therapeutics 2001;296(2):243-51.
2001: Lawrence H Lash
Measurement of glutathione transport.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2001;Chapter 6():Unit6.3.
2000: BS Cummings; R Angeles; Roy Barnard McCauley; Lawrence H Lash
Role of voltage-dependent anion channels in glutathione transport into yeast mitochondria.
Biochemical and biophysical research communications 2000;276(3):940-4.
2000: BS Cummings; Richard C Zangar; Raymond F Novak; Lawrence H Lash
Cytotoxicity of trichloroethylene and S-(1, 2-dichlorovinyl)-L-cysteine in primary cultures of rat renal proximal tubular and distal tubular cells.
Toxicology 2000;150(1-3):83-98.
2000: Timothy P Reilly; Lawrence H Lash; Mark A Doll; David W Hein; Patrick M Woster; Craig K Svensson
A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions.
The Journal of investigative dermatology 2000;114(6):1164-73.
2000: John J Reiners; P Mathieu; C Okafor; David A Putt; Lawrence H Lash
Depletion of cellular glutathione by conditions used for the passaging of adherent cultured cells.
Toxicology letters 2000;115(2):153-63.
2000: Lawrence H Lash; Jean C Parker; C S Scott
Modes of action of trichloroethylene for kidney tumorigenesis.
Environmental health perspectives 2000;108 Suppl 2():225-40.
2000: Lawrence H Lash; Jeffrey W Fisher; John C Lipscomb; Jean C Parker
Metabolism of trichloroethylene.
Environmental health perspectives 2000;108 Suppl 2():177-200.
2000: BS Cummings; J M Lasker; Lawrence H Lash
Expression of glutathione-dependent enzymes and cytochrome P450s in freshly isolated and primary cultures of proximal tubular cells from human kidney.
The Journal of pharmacology and experimental therapeutics 2000;293(2):677-85.
2000: A H Stokes; D Y Lewis; Lawrence H Lash; W Gray Jerome; K W Grant; Michael Aschner; Kent Vrana
Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by L-BSO and apoptosis.
Brain research 2000;858(1):1-8.
2000: BS Cummings; Jean C Parker; Lawrence H Lash
Role of cytochrome P450 and glutathione S-transferase alpha in the metabolism and cytotoxicity of trichloroethylene in rat kidney.
Biochemical pharmacology 2000;59(5):531-43.
2000: BS Cummings; Lawrence H Lash
Metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine in freshly isolated human proximal tubular cells.
Toxicological sciences : an official journal of the Society of Toxicology 2000;53(2):458-66.
2000: Z Chen; David A Putt; Lawrence H Lash
Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria: further evidence for the role of the dicarboxylate and 2-oxoglutarate carriers in mitochondrial glutathione transport.
Archives of biochemistry and biophysics 2000;373(1):193-202.
1999: Rudolfs Zalups; Delon W Barfuss; Lawrence H Lash
Relationships between alterations in glutathione metabolism and the disposition of inorganic mercury in rats: effects of biliary ligation and chemically induced modulation of glutathione status.
Chemico-biological interactions 1999;123(3):171-95.
1999: Lawrence H Lash; David A Putt; Rudolfs Zalups
Influence of exogenous thiols on inorganic mercury-induced injury in renal proximal and distal tubular cells from normal and uninephrectomized rats.
The Journal of pharmacology and experimental therapeutics 1999;291(2):492-502.
1999: Lawrence H Lash; David A Putt
Renal cellular transport of exogenous glutathione: heterogeneity at physiological and pharmacological concentrations.
Biochemical pharmacology 1999;58(5):897-907.
1999: BS Cummings; Richard C Zangar; Raymond F Novak; Lawrence H Lash
Cellular distribution of cytochromes P-450 in the rat kidney.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(4):542-8.
1999: Lawrence H Lash; John C Lipscomb; David A Putt; Jean C Parker
Glutathione conjugation of trichloroethylene in human liver and kidney: kinetics and individual variation.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(3):351-9.
1999: Rudolfs Zalups; Delon W Barfuss; Lawrence H Lash
Disposition of inorganic mercury following biliary obstruction and chemically induced glutathione depletion: dispositional changes one hour after the intravenous administration of mercuric chloride.
Toxicology and applied pharmacology 1999;154(2):135-44.
1999: Lawrence H Lash; David A Putt; W T Brashear; R Abbas; Jean C Parker; Jeffrey W Fisher
Identification of S-(1,2-dichlorovinyl)glutathione in the blood of human volunteers exposed to trichloroethylene.
Journal of toxicology and environmental health. Part A 1999;56(1):1-21.
1998: Lawrence H Lash; T M Visarius; J M Sall; Wei Qian; J J Tokarz
Cellular and subcellular heterogeneity of glutathione metabolism and transport in rat kidney cells.
Toxicology 1998;130(1):1-15.
1998: Adnan A Elfarra; Renee J Krause; A R Last; Lawrence H Lash; Jean C Parker
Species- and sex-related differences in metabolism of trichloroethylene to yield chloral and trichloroethanol in mouse, rat, and human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(8):779-85.
1998: Lawrence H Lash; David A Putt; Rudolfs Zalups
Role of extracellular thiols in accumulation and distribution of inorganic mercury in rat renal proximal and distal tubular cells.
The Journal of pharmacology and experimental therapeutics 1998;285(3):1039-50.
1998: Lawrence H Lash; Wei Qian; David A Putt; K Desai; Adnan A Elfarra; Anna Rita Sicuri; Jean C Parker
Glutathione conjugation of perchloroethylene in rats and mice in vitro: sex-, species-, and tissue-dependent differences.
Toxicology and applied pharmacology 1998;150(1):49-57.
1998: Z Chen; Lawrence H Lash
Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers.
The Journal of pharmacology and experimental therapeutics 1998;285(2):608-18.
1998: Lawrence H Lash
In vitro methods of assessing renal damage.
Toxicologic pathology 1998;26(1):33-42.
1998: Lawrence H Lash; Wei Qian; David A Putt; K Jacobs; Adnan A Elfarra; Renee J Krause; Jean C Parker
Glutathione conjugation of trichloroethylene in rats and mice: sex-, species-, and tissue-dependent differences.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(1):12-9.
1997: Lawrence H Lash; A Shivnani; J Mai; P Chinnaiyan; Renee J Krause; Adnan A Elfarra
Renal cellular transport, metabolism, and cytotoxicity of S-(6-purinyl)glutathione, a prodrug of 6-mercaptopurine, and analogues.
Biochemical pharmacology 1997;54(12):1341-9.
1997: Michael Aschner; Fritz Lorscheider; KS Cowan; DR Conklin; MJ Vimy; Lawrence H Lash
Metallothionein induction in fetal rat brain and neonatal primary astrocyte cultures by in utero exposure to elemental mercury vapor (Hg0).
Brain research 1997;778(1):222-32.
1997: William F Finn; C Nolan; Lawrence H Lash; G Lorenzon; SE Manley; R Safirstein
Urinary biomarkers to detect significant effects of environmental and occupational exposure to nephrotoxins. VI. Future research needs.
Renal failure 1997;19(4):575-94.
1997: A Bernard; Hilmar Stolte; M E De Broe; Patricia W Mueller; H Mason; Lawrence H Lash; B A Fowler
Urinary biomarkers to detect significant effects of environmental and occupational exposure to nephrotoxins. IV. Current information on interpreting the health implications of tests.
Renal failure 1997;19(4):553-66.
1997: Patricia W Mueller; Lawrence H Lash; Robert G Price; Hilmar Stolte; E Gelpi; T Maack; WO Berndt
Urinary biomarkers to detect significant effects of environmental and occupational exposure to nephrotoxins. I. Categories of tests for detecting effects of nephrotoxins.
Renal failure 1997;19(4):505-21.
1997: Rudolfs Zalups; Lawrence H Lash
Binding of mercury in renal brush-border and basolateral membrane-vesicles.
Biochemical pharmacology 1997;53(12):1889-900.
1997: Rudolfs Zalups; Lawrence H Lash
Depletion of glutathione in the kidney and the renal disposition of administered inorganic mercury.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(4):516-23.
1996: Charles V Smith; Dean P Jones; TM Guenthner; Lawrence H Lash; B H Lauterburg
Compartmentation of glutathione: implications for the study of toxicity and disease.
Toxicology and applied pharmacology 1996;140(1):1-12.
1996: Sanjiv Bhave; J N Johannessen; Lawrence H Lash; TD Wakade; Arun R. Wakade
Age-dependent sensitivity of cultured peripheral sympathetic neurons to 1-methyl-4-phenylpyridinium: role of glutathione.
Journal of neurochemistry 1996;67(2):557-65.
1996: T M Visarius; David A Putt; J M Schare; D M Pegouske; Lawrence H Lash
Pathways of glutathione metabolism and transport in isolated proximal tubular cells from rat kidney.
Biochemical pharmacology 1996;52(2):259-72.
1996: Lawrence H Lash; Rudolfs Zalups
Alterations in renal cellular glutathione metabolism after in vivo administration of a subtoxic dose of mercuric chloride.
Journal of biochemical toxicology 1996;11(1):1-9.
1996: Lawrence H Lash; J J Tokarz; Z Chen; B M Pedrosi; E B Woods
ATP depletion by iodoacetate and cyanide in renal distal tubular cells.
The Journal of pharmacology and experimental therapeutics 1996;276(1):194-205.
1995: Lawrence H Lash; J J Tokarz
Oxidative stress and cytotoxicity of 4-(2-thienyl)butyric acid in isolated rat renal proximal tubular and distal tubular cells.
Toxicology 1995;103(3):167-75.
1995: Lawrence H Lash; J J Tokarz; D M Pegouske
Susceptibility of primary cultures of proximal tubular and distal tubular cells from rat kidney to chemically induced toxicity.
Toxicology 1995;103(2):85-103.
1995: Michael Aschner; K J Mullaney; D E Wagoner; Lawrence H Lash; Harold K Kimelberg
Adenosine modulates methylmercuric chloride (MeHgCl)-induced D-aspartate release from neonatal rat primary astrocyte cultures.
Brain research 1995;689(1):1-8.
1995: Lawrence H Lash; Y Xu; Adnan A Elfarra; R J Duescher; Jean C Parker
Glutathione-dependent metabolism of trichloroethylene in isolated liver and kidney cells of rats and its role in mitochondrial and cellular toxicity.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(8):846-53.
1995: Lawrence H Lash
Intracellular distribution of thiols and disulfides: assay of mitochondrial glutathione transport.
Methods in enzymology 1995;252():14-26.
1994: Lawrence H Lash
Role of renal metabolism in risk to toxic chemicals.
Environmental health perspectives 1994;102 Suppl 11():75-9.
1994: Michael Aschner; K J Mullaney; D Wagoner; Lawrence H Lash; Harold K Kimelberg
Intracellular glutathione (GSH) levels modulate mercuric chloride (MC)- and methylmercuric chloride (MeHgCl)-induced amino acid release from neonatal rat primary astrocytes cultures.
Brain research 1994;664(1-2):133-40.
1994: Lawrence H Lash; J J Tokarz; E B Woods
Renal cell type specificity of cephalosporin-induced cytotoxicity in suspensions of isolated proximal tubular and distal tubular cells.
Toxicology 1994;94(1-3):97-118.
1994: Rudolfs Zalups; Lawrence H Lash
Advances in understanding the renal transport and toxicity of mercury.
Journal of toxicology and environmental health 1994;42(1):1-44.
1994: Lawrence H Lash; P J Sausen; R J Duescher; A J Cooley; Adnan A Elfarra
Roles of cysteine conjugate beta-lyase and S-oxidase in nephrotoxicity: studies with S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2-dichlorovinyl)-L-cysteine sulfoxide.
The Journal of pharmacology and experimental therapeutics 1994;269(1):374-83.
1994: Lawrence H Lash; Rudolfs Zalups
Activities of enzymes involved in renal cellular glutathione metabolism after uninephrectomy in the rat.
Archives of biochemistry and biophysics 1994;309(1):129-38.
1993: Lawrence H Lash; J J Tokarz; E B Woods; B M Pedrosi
Hypoxia and oxygen dependence of cytotoxicity in renal proximal tubular and distal tubular cells.
Biochemical pharmacology 1993;45(1):191-200.
1992: Lawrence H Lash; Rudolfs Zalups
Mercuric chloride-induced cytotoxicity and compensatory hypertrophy in rat kidney proximal tubular cells.
The Journal of pharmacology and experimental therapeutics 1992;261(2):819-29.
1991: T B McKernan; E B Woods; Lawrence H Lash
Uptake of glutathione by renal cortical mitochondria.
Archives of biochemistry and biophysics 1991;288(2):653-63.
1991: Lawrence H Lash; E B Woods
Cytotoxicity of alkylating agents in isolated rat kidney proximal tubular and distal tubular cells.
Archives of biochemistry and biophysics 1991;286(1):46-56.
1990: Rudolfs Zalups; Lawrence H Lash
Effects of uninephrectomy and mercuric chloride on renal glutathione homeostasis.
The Journal of pharmacology and experimental therapeutics 1990;254(3):962-70.
1990: Lawrence H Lash
Susceptibility to toxic injury in different nephron cell populations.
Toxicology letters 1990;53(1-2):97-104.
1990: Lawrence H Lash; J J Tokarz
Oxidative stress in isolated rat renal proximal and distal tubular cells.
The American journal of physiology 1990;259(2 Pt 2):F338-47.
1990: Lawrence H Lash; A A Elfarra; D Rakiewicz-Nemeth; MW Anders
Bioactivation mechanism of cytotoxic homocysteine S-conjugates.
Archives of biochemistry and biophysics 1990;276(2):322-30.
1990: Lawrence H Lash; R M Nelson; R A Van Dyke; MW Anders
Purification and characterization of human kidney cytosolic cysteine conjugate beta-lyase activity.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(1):50-4.
1989: Lawrence H Lash; J J Tokarz
Isolation of two distinct populations of cells from rat kidney cortex and their use in the study of chemical-induced toxicity.
Analytical biochemistry 1989;182(2):271-9.
1989: Lawrence H Lash; MW Anders
Uptake of nephrotoxic S-conjugates by isolated rat renal proximal tubular cells.
The Journal of pharmacology and experimental therapeutics 1989;248(2):531-7.
1988: MW Anders; Lawrence H Lash; W Dekant; A A Elfarra; D R Dohn
Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites.
Critical reviews in toxicology 1988;18(4):311-41.
1987: W Dekant; Lawrence H Lash; MW Anders
Bioactivation mechanism of the cytotoxic and nephrotoxic S-conjugate S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7443-7.
1987: Lawrence H Lash; MW Anders
Mechanism of S-(1,2-dichlorovinyl)-L-cysteine- and S-(1,2-dichlorovinyl)-L-homocysteine-induced renal mitochondrial toxicity.
Molecular pharmacology 1987;32(4):549-56.
1987: A A Elfarra; Lawrence H Lash; M W Anders
Alpha-ketoacids stimulate rat renal cysteine conjugate beta-lyase activity and potentiate the cytotoxicity of S-(1,2-dichlorovinyl)-L-cysteine.
Molecular pharmacology 1987;31(2):208-12.
1987: M W Anders; A A Elfarra; Lawrence H Lash
Cellular effects of reactive intermediates: nephrotoxicity of S-conjugates of amino acids.
Archives of toxicology 1987;60(1-3):103-8.
1986: Lawrence H Lash; A A Elfarra; M W Anders
S-(1,2-dichlorovinyl)-L-homocysteine-induced cytotoxicity in isolated rat kidney cells.
Archives of biochemistry and biophysics 1986;251(2):432-9.
1986: Lawrence H Lash; M W Anders
Cytotoxicity of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine in isolated rat kidney cells.
The Journal of biological chemistry 1986;261(28):13076-81.
1986: K Banki; A A Elfarra; Lawrence H Lash; M W Anders
Metabolism of S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine to hydrogen sulfide and the role of hydrogen sulfide in S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine-induced mitochondrial toxicity.
Biochemical and biophysical research communications 1986;138(2):707-13.
1986: Lawrence H Lash; T M Hagen; Dean P Jones
Exogenous glutathione protects intestinal epithelial cells from oxidative injury.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(13):4641-5.
1986: Lawrence H Lash; Dean P Jones
Purification and properties of the membranal thiol oxidase from porcine kidney.
Archives of biochemistry and biophysics 1986;247(1):120-30.
1986: Lawrence H Lash; A A Elfarra; M W Anders
Renal cysteine conjugate beta-lyase. Bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane.
The Journal of biological chemistry 1986;261(13):5930-5.
1986: A A Elfarra; Lawrence H Lash; M W Anders
Metabolic activation and detoxication of nephrotoxic cysteine and homocysteine S-conjugates.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(8):2667-71.
1986: M W Anders; Lawrence H Lash; A A Elfarra
Nephrotoxic amino acid and glutathione S-conjugates: formation and renal activation.
Advances in experimental medicine and biology 1986;197():443-55.
1985: D R Dohn; J Leininger; Lawrence H Lash; A J Quebbemann; M W Anders
Nephrotoxicity of S-(2-chloro-1,1,2-trifluoroethyl)glutathione and S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine, the glutathione and cysteine conjugates of chlorotrifluoroethene.
The Journal of pharmacology and experimental therapeutics 1985;235(3):851-7.
1985: Lawrence H Lash; Dean P Jones
Uptake of the glutathione conjugate S-(1,2-dichlorovinyl)glutathione by renal basal-lateral membrane vesicles and isolated kidney cells.
Molecular pharmacology 1985;28(3):278-82.
1985: Lawrence H Lash; Dean P Jones
Distribution of oxidized and reduced forms of glutathione and cysteine in rat plasma.
Archives of biochemistry and biophysics 1985;240(2):583-92.
1984: Lawrence H Lash; Dean P Jones
Renal glutathione transport. Characteristics of the sodium-dependent system in the basal-lateral membrane.
The Journal of biological chemistry 1984;259(23):14508-14.
1984: Lawrence H Lash; Dean P Jones
Characteristics of cysteine uptake in intestinal basolateral membrane vesicles.
The American journal of physiology 1984;247(4 Pt 1):G394-401.
1984: Lawrence H Lash; Dean P Jones; S Orrenius
The renal thiol (glutathione) oxidase. Subcellular localization and properties.
Biochimica et biophysica acta 1984;779(2):191-200.
1983: Lawrence H Lash; Dean P Jones
Characterization of the membrane-associated thiol oxidase activity of rat small-intestinal epithelium.
Archives of biochemistry and biophysics 1983;225(1):344-52.
1983: Lawrence H Lash; Dean P Jones
Transport of glutathione by renal basal-lateral membrane vesicles.
Biochemical and biophysical research communications 1983;112(1):55-60.
1982: Lawrence H Lash; Dean P Jones
Localization of the membrane-associated thiol oxidase of rat kidney to the basal-lateral plasma membrane.
The Biochemical journal 1982;203(2):371-6.