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Lawrence Lash

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Co-Publications
Name
33
Putt, David
16
Zalups, Rudolfs
15
Parker, Jean
12
Aschner, Michael
11
Jones, Dean
10
Elfarra, Adnan
9
Hueni, Sarah
7
Cummings, BS
6
Dorman, David
6
Erikson, Keith
6
Anders, MW
6
Krause, Renee
5
Xu, Feng
5
Qian, Wei
4
Forkert, Poh-Gek

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Publications

TOP 3
Zhong Qing; Terlecky Stanley R; Lash Lawrence H
Diabetes increases susceptibility of primary cultures of rat proximal tubular cells to chemically induced injury.
Xu Feng; Papanayotou Irene; Putt David A; Wang Jian; Lash Lawrence H
Role of mitochondrial dysfunction in cellular responses to S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells.
Manickam Devika S; Hirata Aiko; Putt David A; Lash Lawrence H; Hirata Fusao; Oupický David
Overexpression of Bcl-2 as a proxy redox stimulus to enhance activity of non-viral redox-responsive delivery vectors.

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All Publications

2009: Zhong Qing; Terlecky Stanley R; Lash Lawrence H
Diabetes increases susceptibility of primary cultures of rat proximal tubular cells to chemically induced injury.
Toxicology and applied pharmacology 2009;241(1):1-13.
2008: Xu Feng; Papanayotou Irene; Putt David A; Wang Jian; Lash Lawrence H
Role of mitochondrial dysfunction in cellular responses to S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells.
Biochemical pharmacology 2008;76(4):552-67.
2008: Manickam Devika S; Hirata Aiko; Putt David A; Lash Lawrence H; Hirata Fusao; Oupický David
Overexpression of Bcl-2 as a proxy redox stimulus to enhance activity of non-viral redox-responsive delivery vectors.
Biomaterials 2008;29(17):2680-8.
2008: Zhong Qing; Putt David A; Xu Feng; Lash Lawrence H
Hepatic mitochondrial transport of glutathione: studies in isolated rat liver mitochondria and H4IIE rat hepatoma cells.
Archives of biochemistry and biophysics 2008;474(1):119-27.
2008: Erikson Keith M; Dorman David C; Lash Lawrence H; Aschner Michael
Duration of airborne-manganese exposure in rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity.
Neurotoxicology 2008;29(3):377-85.
2008: Lash Lawrence H
Epidermal growth factor receptor ligands and renal epithelial cell proliferation.
American journal of physiology. Renal physiology 2008;294(3):F457-8.
2008: Lash Lawrence H
Mitochondrial GSH transport and intestinal cell injury: a commentary on "Contribution of mitochondrial GSH transport to matrix GSH status and colonic epithelial cell apoptosis".
Free radical biology & medicine 2008;44(5):765-7.
2008: Lash Lawrence H; Putt David A; Cai Hongliang
Drug metabolism enzyme expression and activity in primary cultures of human proximal tubular cells.
Toxicology 2008;244(1):56-65.
2007: Lash Lawrence H; Putt David A; Xu Feng; Matherly Larry H
Role of rat organic anion transporter 3 (Oat3) in the renal basolateral transport of glutathione.
Chemico-biological interactions 2007;170(2):124-34.
2007: Lash Lawrence H; Putt David A; Hueni Sarah E; Payton Scott G; Zwickl Joshua
Interactive toxicity of inorganic mercury and trichloroethylene in rat and human proximal tubules: effects on apoptosis, necrosis, and glutathione status.
Toxicology and applied pharmacology 2007;221(3):349-62.
2007: Lash Lawrence H; Putt David A; Huang Paul; Hueni Sarah E; Parker Jean C
Modulation of hepatic and renal metabolism and toxicity of trichloroethylene and perchloroethylene by alterations in status of cytochrome P450 and glutathione.
Toxicology 2007;235(1-2):11-26.
2007: Erikson Keith M; Dorman David C; Lash Lawrence H; Aschner Michael
Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2007;97(2):459-66.
2006: Lash Lawrence H; Putt David A; Cai Hongliang
Membrane transport function in primary cultures of human proximal tubular cells.
Toxicology 2006;228(2-3):200-18.
2006: Lash Lawrence H; Putt David A; Zalups Rudolfs K
Influence of compensatory renal growth on susceptibility of primary cultures of renal cells to chemically induced injury.
Toxicological sciences : an official journal of the Society of Toxicology 2006;94(2):417-27.
2006: Lash Lawrence H
Mitochondrial glutathione transport: physiological, pathological and toxicological implications.
Chemico-biological interactions 2006;163(1-2):54-67.
2006: Lash Lawrence H; Putt David A; Parker Jean C
Metabolism and tissue distribution of orally administered trichloroethylene in male and female rats: identification of glutathione- and cytochrome P-450-derived metabolites in liver, kidney, blood, and urine.
Journal of toxicology and environmental health. Part A 2006;69(13):1285-309.
2006: Zalups Rudolfs K; Lash Lawrence H
Cystine alters the renal and hepatic disposition of inorganic mercury and plasma thiol status.
Toxicology and applied pharmacology 2006;214(1):88-97.
2006: Xu Feng; Putt David A; Matherly Larry H; Lash Lawrence H
Modulation of expression of rat mitochondrial 2-oxoglutarate carrier in NRK-52E cells alters mitochondrial transport and accumulation of glutathione and susceptibility to chemically induced apoptosis.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1175-86.
2006: Forkert Poh-Gek; Millen Brandie; Lash Lawrence H; Putt David A; Ghanayem Burhan I
Pulmonary bronchiolar cytotoxicity and formation of dichloroacetyl lysine protein adducts in mice treated with trichloroethylene.
The Journal of pharmacology and experimental therapeutics 2006;316(2):520-9.
2006: Donahue Ashley N; Aschner Michael; Lash Lawrence H; Syversen Tore; Sonntag William E
Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus.
Mechanisms of ageing and development 2006;127(1):57-63.
2006: Erikson Keith M; Dorman David C; Fitsanakis Vanessa; Lash Lawrence H; Aschner Michael
Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese.
Biological trace element research 2006;111(1-3):199-215.
2005: Lash Lawrence H; Hueni Sarah E; Putt David A; Zalups Rudolfs K
Role of organic anion and amino acid carriers in transport of inorganic mercury in rat renal basolateral membrane vesicles: influence of compensatory renal growth.
Toxicological sciences : an official journal of the Society of Toxicology 2005;88(2):630-44.
2005: Forkert Poh-Gek; Baldwin R Michael; Millen Brandie; Lash Lawrence H; Putt David A; Shultz Michael A; Collins Kathy S
Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(10):1429-37.
2005: Lash Lawrence H; Putt David A; Hueni Sarah E; Horwitz Beth P
Molecular markers of trichloroethylene-induced toxicity in human kidney cells.
Toxicology and applied pharmacology 2005;206(2):157-68.
2005: Erikson Keith M; Dorman David C; Lash Lawrence H; Aschner Michael
Persistent alterations in biomarkers of oxidative stress resulting from combined in utero and neonatal manganese inhalation.
Biological trace element research 2005;104(2):151-63.
2005: Lash Lawrence H
Role of glutathione transport processes in kidney function.
Toxicology and applied pharmacology 2005;204(3):329-42.
2004: Erikson Keith M; Dorman David C; Lash Lawrence H; Dobson Allison W; Aschner Michael
Airborne manganese exposure differentially affects end points of oxidative stress in an age- and sex-dependent manner.
Biological trace element research 2004;100(1):49-62.
2004: Stredrick Denise L; Stokes Alan H; Worst Travis J; Freeman Willard M; Johnson Elizabeth A; Lash Lawrence H; Aschner Michael; Vrana Kent E
Manganese-induced cytotoxicity in dopamine-producing cells.
Neurotoxicology 2004;25(4):543-53.
2003: Lash Lawrence H
The mitochondrial benzodiazepine receptor as a potential target protein for drug development: demonstration of functional significance with cell lines exhibiting differential expression of Bcl-2.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(1):1-3.
2003: Lash Lawrence H; Putt David A; Hueni Sarah E; Krause Renee J; Elfarra Adnan A
Roles of necrosis, Apoptosis, and mitochondrial dysfunction in S-(1,2-dichlorovinyl)-L-cysteine sulfoxide-induced cytotoxicity in primary cultures of human renal proximal tubular cells.
The Journal of pharmacology and experimental therapeutics 2003;305(3):1163-72.
2003: Lash Lawrence H; Hines Ronald N; Gonzalez Frank J; Zacharewski Timothy R; Rothstein Mark A
Genetics and susceptibility to toxic chemicals: do you (or should you) know your genetic profile?
The Journal of pharmacology and experimental therapeutics 2003;305(2):403-9.
2003: Forkert Poh-Gek; Lash Lawrence; Tardif Robert; Tanphaichitr Nongnuj; Vandevoort Catherine; Moussa Madeleine
Identification of trichloroethylene and its metabolites in human seminal fluid of workers exposed to trichloroethylene.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(3):306-11.
2003: Krause Renee J; Lash Lawrence H; Elfarra Adnan A
Human kidney flavin-containing monooxygenases and their potential roles in cysteine s-conjugate metabolism and nephrotoxicity.
The Journal of pharmacology and experimental therapeutics 2003;304(1):185-91.
2002: Lash Lawrence H; Putt David A; Hueni Sarah E; Cao Wei; Xu Feng; Kulidjian Stephen J; Horwitz Judith P
Cellular energetics and glutathione status in NRK-52E cells: toxicological implications.
Biochemical pharmacology 2002;64(10):1533-46.
2002: Lash Lawrence H; Putt David A; Matherly Larry H
Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter.
The Journal of pharmacology and experimental therapeutics 2002;303(2):476-86.
2002: Forkert Poh-Gek; Lash Lawrence H; Nadeau Veronique; Tardif Robert; Simmonds Andrea
Metabolism and toxicity of trichloroethylene in epididymis and testis.
Toxicology and applied pharmacology 2002;182(3):244-54.
2002: Weber Sarah; Dorman David C; Lash Lawrence H; Erikson Keith; Vrana Kent E; Aschner Michael
Effects of manganese (Mn) on the developing rat brain: oxidative-stress related endpoints.
Neurotoxicology 2002;23(2):169-75.
2002: Lash Lawrence H; Qian Wei; Putt David A; Hueni Sarah E; Elfarra Adnan A; Sicuri Anna Rita; Parker Jean C
Renal toxicity of perchloroethylene and S-(1,2,2-trichlorovinyl)glutathione in rats and mice: sex- and species-dependent differences.
Toxicology and applied pharmacology 2002;179(3):163-71.
2001: Lash L H; Hueni S E; Putt D A
Apoptosis, necrosis, and cell proliferation induced by S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells.
Toxicology and applied pharmacology 2001;177(1):1-16.
2001: Muralidhara S; Ramanathan R; Mehta S M; Lash L H; Acosta D; Bruckner J V
Acute, subacute, and subchronic oral toxicity studies of 1,1-dichloroethane in rats: application to risk evaluation.
Toxicological sciences : an official journal of the Society of Toxicology 2001;64(1):135-45.
2001: Lash L H; Putt D A; Horky S J; Zalups R K
Functional and toxicological characteristics of isolated renal mitochondria: impact of compensatory renal growth.
Biochemical pharmacology 2001;62(3):383-95.
2001: Rankin G O; Hong S K; Anestis D K; Lash L H; Miles S L
In vitro nephrotoxicity induced by N-(3,5-dichlorophenyl)succinimide (NDPS) metabolites in isolated renal cortical cells from male and female Fischer 344 rats: evidence for a nephrotoxic sulfate conjugate metabolite.
Toxicology 2001;163(2-3):73-82.
2001: Lash L H; Parker J C
Hepatic and renal toxicities associated with perchloroethylene.
Pharmacological reviews 2001;53(2):177-208.
2001: Lash L H; Qian W; Putt D A; Hueni S E; Elfarra A A; Krause R J; Parker J C
Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences.
The Journal of pharmacology and experimental therapeutics 2001;297(1):155-64.
2001: Cummings B S; Parker J C; Lash L H
Cytochrome p450-dependent metabolism of trichloroethylene in rat kidney.
Toxicological sciences : an official journal of the Society of Toxicology 2001;60(1):11-9.
2001: Lash L H; Putt D A; Zalups R K
Biochemical and functional characteristics of cultured renal epithelial cells from uninephrectomized rats: factors influencing nephrotoxicity.
The Journal of pharmacology and experimental therapeutics 2001;296(2):243-51.
2000: Cummings B S; Angeles R; McCauley R B; Lash L H
Role of voltage-dependent anion channels in glutathione transport into yeast mitochondria.
Biochemical and biophysical research communications 2000;276(3):940-4.
2000: Cummings B S; Zangar R C; Novak R F; Lash L H
Cytotoxicity of trichloroethylene and S-(1, 2-dichlorovinyl)-L-cysteine in primary cultures of rat renal proximal tubular and distal tubular cells.
Toxicology 2000;150(1-3):83-98.
2000: Reilly T P; Lash L H; Doll M A; Hein D W; Woster P M; Svensson C K
A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions.
The Journal of investigative dermatology 2000;114(6):1164-73.
2000: Lash L H; Parker J C; Scott C S
Modes of action of trichloroethylene for kidney tumorigenesis.
Environmental health perspectives 2000;108 Suppl 2():225-40.
2000: Lash L H; Fisher J W; Lipscomb J C; Parker J C
Metabolism of trichloroethylene.
Environmental health perspectives 2000;108 Suppl 2():177-200.
2000: Reiners J J; Mathieu P; Okafor C; Putt D A; Lash L H
Depletion of cellular glutathione by conditions used for the passaging of adherent cultured cells.
Toxicology letters 2000;115(2):153-63.
2000: Cummings B S; Lasker J M; Lash L H
Expression of glutathione-dependent enzymes and cytochrome P450s in freshly isolated and primary cultures of proximal tubular cells from human kidney.
The Journal of pharmacology and experimental therapeutics 2000;293(2):677-85.
2000: Stokes A H; Lewis D Y; Lash L H; Jerome W G; Grant K W; Aschner M; Vrana K E
Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by L-BSO and apoptosis.
Brain research 2000;858(1):1-8.
2000: Cummings B S; Parker J C; Lash L H
Role of cytochrome P450 and glutathione S-transferase alpha in the metabolism and cytotoxicity of trichloroethylene in rat kidney.
Biochemical pharmacology 2000;59(5):531-43.
2000: Cummings B S; Lash L H
Metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine in freshly isolated human proximal tubular cells.
Toxicological sciences : an official journal of the Society of Toxicology 2000;53(2):458-66.
2000: Chen Z; Putt D A; Lash L H
Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria: further evidence for the role of the dicarboxylate and 2-oxoglutarate carriers in mitochondrial glutathione transport.
Archives of biochemistry and biophysics 2000;373(1):193-202.
1999: Zalups R K; Barfuss D W; Lash L H
Relationships between alterations in glutathione metabolism and the disposition of inorganic mercury in rats: effects of biliary ligation and chemically induced modulation of glutathione status.
Chemico-biological interactions 1999;123(3):171-95.
1999: Lash L H; Putt D A; Zalups R K
Influence of exogenous thiols on inorganic mercury-induced injury in renal proximal and distal tubular cells from normal and uninephrectomized rats.
The Journal of pharmacology and experimental therapeutics 1999;291(2):492-502.
1999: Lash L H; Putt D A
Renal cellular transport of exogenous glutathione: heterogeneity at physiological and pharmacological concentrations.
Biochemical pharmacology 1999;58(5):897-907.
1999: Cummings B S; Zangar R C; Novak R F; Lash L H
Cellular distribution of cytochromes P-450 in the rat kidney.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(4):542-8.
1999: Lash L H; Lipscomb J C; Putt D A; Parker J C
Glutathione conjugation of trichloroethylene in human liver and kidney: kinetics and individual variation.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(3):351-9.
1999: Zalups R K; Barfuss D W; Lash L H
Disposition of inorganic mercury following biliary obstruction and chemically induced glutathione depletion: dispositional changes one hour after the intravenous administration of mercuric chloride.
Toxicology and applied pharmacology 1999;154(2):135-44.
1999: Lash L H; Putt D A; Brashear W T; Abbas R; Parker J C; Fisher J W
Identification of S-(1,2-dichlorovinyl)glutathione in the blood of human volunteers exposed to trichloroethylene.
Journal of toxicology and environmental health. Part A 1999;56(1):1-21.
1998: Lash L H; Visarius T M; Sall J M; Qian W; Tokarz J J
Cellular and subcellular heterogeneity of glutathione metabolism and transport in rat kidney cells.
Toxicology 1998;130(1):1-15.
1998: Elfarra A A; Krause R J; Last A R; Lash L H; Parker J C
Species- and sex-related differences in metabolism of trichloroethylene to yield chloral and trichloroethanol in mouse, rat, and human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(8):779-85.
1998: Lash L H; Putt D A; Zalups R K
Role of extracellular thiols in accumulation and distribution of inorganic mercury in rat renal proximal and distal tubular cells.
The Journal of pharmacology and experimental therapeutics 1998;285(3):1039-50.
1998: Lash L H; Qian W; Putt D A; Desai K; Elfarra A A; Sicuri A R; Parker J C
Glutathione conjugation of perchloroethylene in rats and mice in vitro: sex-, species-, and tissue-dependent differences.
Toxicology and applied pharmacology 1998;150(1):49-57.
1998: Chen Z; Lash L H
Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers.
The Journal of pharmacology and experimental therapeutics 1998;285(2):608-18.
1998: Lash L H
In vitro methods of assessing renal damage.
Toxicologic pathology 1998;26(1):33-42.
1998: Lash L H; Qian W; Putt D A; Jacobs K; Elfarra A A; Krause R J; Parker J C
Glutathione conjugation of trichloroethylene in rats and mice: sex-, species-, and tissue-dependent differences.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(1):12-9.
1997: Aschner M; Lorscheider F L; Cowan K S; Conklin D R; Vimy M J; Lash L H
Metallothionein induction in fetal rat brain and neonatal primary astrocyte cultures by in utero exposure to elemental mercury vapor (Hg0).
Brain research 1997;778(1):222-32.
1997: Lash L H; Shivnani A; Mai J; Chinnaiyan P; Krause R J; Elfarra A A
Renal cellular transport, metabolism, and cytotoxicity of S-(6-purinyl)glutathione, a prodrug of 6-mercaptopurine, and analogues.
Biochemical pharmacology 1997;54(12):1341-9.
1997: Finn W F; Nolan C; Lash L H; Lorenzon G; Manley S E; Safirstein R
Urinary biomarkers to detect significant effects of environmental and occupational exposure to nephrotoxins. VI. Future research needs.
Renal failure 1997;19(4):575-94.
1997: Bernard A; Stolte H; De Broe M E; Mueller P W; Mason H; Lash L H; Fowler B A
Urinary biomarkers to detect significant effects of environmental and occupational exposure to nephrotoxins. IV. Current information on interpreting the health implications of tests.
Renal failure 1997;19(4):553-66.
1997: Mueller P W; Lash L H; Price R G; Stolte H; Gelpi E; Maack T; Berndt W O
Urinary biomarkers to detect significant effects of environmental and occupational exposure to nephrotoxins. I. Categories of tests for detecting effects of nephrotoxins.
Renal failure 1997;19(4):505-21.
1997: Zalups R K; Lash L H
Binding of mercury in renal brush-border and basolateral membrane-vesicles.
Biochemical pharmacology 1997;53(12):1889-900.
1997: Zalups R K; Lash L H
Depletion of glutathione in the kidney and the renal disposition of administered inorganic mercury.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(4):516-23.
1996: Smith C V; Jones D P; Guenthner T M; Lash L H; Lauterburg B H
Compartmentation of glutathione: implications for the study of toxicity and disease.
Toxicology and applied pharmacology 1996;140(1):1-12.
1996: Bhave S V; Johannessen J N; Lash L H; Wakade T D; Wakade A R
Age-dependent sensitivity of cultured peripheral sympathetic neurons to 1-methyl-4-phenylpyridinium: role of glutathione.
Journal of neurochemistry 1996;67(2):557-65.
1996: Visarius T M; Putt D A; Schare J M; Pegouske D M; Lash L H
Pathways of glutathione metabolism and transport in isolated proximal tubular cells from rat kidney.
Biochemical pharmacology 1996;52(2):259-72.
1996: Lash L H; Tokarz J J; Chen Z; Pedrosi B M; Woods E B
ATP depletion by iodoacetate and cyanide in renal distal tubular cells.
The Journal of pharmacology and experimental therapeutics 1996;276(1):194-205.
1996: Lash L H; Zalups R K
Alterations in renal cellular glutathione metabolism after in vivo administration of a subtoxic dose of mercuric chloride.
Journal of biochemical toxicology 1996;11(1):1-9.
1995: Lash L H; Tokarz J J
Oxidative stress and cytotoxicity of 4-(2-thienyl)butyric acid in isolated rat renal proximal tubular and distal tubular cells.
Toxicology 1995;103(3):167-75.
1995: Lash L H; Tokarz J J; Pegouske D M
Susceptibility of primary cultures of proximal tubular and distal tubular cells from rat kidney to chemically induced toxicity.
Toxicology 1995;103(2):85-103.
1995: Aschner M; Mullaney K J; Wagoner D E; Lash L H; Kimelberg H K
Adenosine modulates methylmercuric chloride (MeHgCl)-induced D-aspartate release from neonatal rat primary astrocyte cultures.
Brain research 1995;689(1):1-8.
1995: Lash L H; Xu Y; Elfarra A A; Duescher R J; Parker J C
Glutathione-dependent metabolism of trichloroethylene in isolated liver and kidney cells of rats and its role in mitochondrial and cellular toxicity.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(8):846-53.
1995: Lash L H
Intracellular distribution of thiols and disulfides: assay of mitochondrial glutathione transport.
Methods in enzymology 1995;252():14-26.
1994: Lash L H
Role of renal metabolism in risk to toxic chemicals.
Environmental health perspectives 1994;102 Suppl 11():75-9.
1994: Aschner M; Mullaney K J; Wagoner D; Lash L H; Kimelberg H K
Intracellular glutathione (GSH) levels modulate mercuric chloride (MC)- and methylmercuric chloride (MeHgCl)-induced amino acid release from neonatal rat primary astrocytes cultures.
Brain research 1994;664(1-2):133-40.
1994: Lash L H; Tokarz J J; Woods E B
Renal cell type specificity of cephalosporin-induced cytotoxicity in suspensions of isolated proximal tubular and distal tubular cells.
Toxicology 1994;94(1-3):97-118.
1994: Zalups R K; Lash L H
Advances in understanding the renal transport and toxicity of mercury.
Journal of toxicology and environmental health 1994;42(1):1-44.
1994: Lash L H; Sausen P J; Duescher R J; Cooley A J; Elfarra A A
Roles of cysteine conjugate beta-lyase and S-oxidase in nephrotoxicity: studies with S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2-dichlorovinyl)-L-cysteine sulfoxide.
The Journal of pharmacology and experimental therapeutics 1994;269(1):374-83.
1994: Lash L H; Zalups R K
Activities of enzymes involved in renal cellular glutathione metabolism after uninephrectomy in the rat.
Archives of biochemistry and biophysics 1994;309(1):129-38.
1993: Lash L H; Tokarz J J; Woods E B; Pedrosi B M
Hypoxia and oxygen dependence of cytotoxicity in renal proximal tubular and distal tubular cells.
Biochemical pharmacology 1993;45(1):191-200.
1992: Lash L H; Zalups R K
Mercuric chloride-induced cytotoxicity and compensatory hypertrophy in rat kidney proximal tubular cells.
The Journal of pharmacology and experimental therapeutics 1992;261(2):819-29.
1991: McKernan T B; Woods E B; Lash L H
Uptake of glutathione by renal cortical mitochondria.
Archives of biochemistry and biophysics 1991;288(2):653-63.
1991: Lash L H; Woods E B
Cytotoxicity of alkylating agents in isolated rat kidney proximal tubular and distal tubular cells.
Archives of biochemistry and biophysics 1991;286(1):46-56.
1990: Zalups R K; Lash L H
Effects of uninephrectomy and mercuric chloride on renal glutathione homeostasis.
The Journal of pharmacology and experimental therapeutics 1990;254(3):962-70.
1990: Lash L H
Susceptibility to toxic injury in different nephron cell populations.
Toxicology letters 1990;53(1-2):97-104.
1990: Lash L H; Tokarz J J
Oxidative stress in isolated rat renal proximal and distal tubular cells.
The American journal of physiology 1990;259(2 Pt 2):F338-47.
1990: Lash L H; Elfarra A A; Rakiewicz-Nemeth D; Anders M W
Bioactivation mechanism of cytotoxic homocysteine S-conjugates.
Archives of biochemistry and biophysics 1990;276(2):322-30.
1990: Lash L H; Nelson R M; Van Dyke R A; Anders M W
Purification and characterization of human kidney cytosolic cysteine conjugate beta-lyase activity.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(1):50-4.
1989: Lash L H; Tokarz J J
Isolation of two distinct populations of cells from rat kidney cortex and their use in the study of chemical-induced toxicity.
Analytical biochemistry 1989;182(2):271-9.
1989: Lash L H; Anders M W
Uptake of nephrotoxic S-conjugates by isolated rat renal proximal tubular cells.
The Journal of pharmacology and experimental therapeutics 1989;248(2):531-7.
1988: Anders M W; Lash L; Dekant W; Elfarra A A; Dohn D R
Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites.
Critical reviews in toxicology 1988;18(4):311-41.
1987: Dekant W; Lash L H; Anders M W
Bioactivation mechanism of the cytotoxic and nephrotoxic S-conjugate S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7443-7.
1987: Lash L H; Anders M W
Mechanism of S-(1,2-dichlorovinyl)-L-cysteine- and S-(1,2-dichlorovinyl)-L-homocysteine-induced renal mitochondrial toxicity.
Molecular pharmacology 1987;32(4):549-56.
1987: Elfarra A A; Lash L H; Anders M W
Alpha-ketoacids stimulate rat renal cysteine conjugate beta-lyase activity and potentiate the cytotoxicity of S-(1,2-dichlorovinyl)-L-cysteine.
Molecular pharmacology 1987;31(2):208-12.
1987: Anders M W; Elfarra A A; Lash L H
Cellular effects of reactive intermediates: nephrotoxicity of S-conjugates of amino acids.
Archives of toxicology 1987;60(1-3):103-8.
1986: Lash L H; Elfarra A A; Anders M W
S-(1,2-dichlorovinyl)-L-homocysteine-induced cytotoxicity in isolated rat kidney cells.
Archives of biochemistry and biophysics 1986;251(2):432-9.
1986: Lash L H; Anders M W
Cytotoxicity of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine in isolated rat kidney cells.
The Journal of biological chemistry 1986;261(28):13076-81.
1986: Banki K; Elfarra A A; Lash L H; Anders M W
Metabolism of S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine to hydrogen sulfide and the role of hydrogen sulfide in S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine-induced mitochondrial toxicity.
Biochemical and biophysical research communications 1986;138(2):707-13.
1986: Lash L H; Hagen T M; Jones D P
Exogenous glutathione protects intestinal epithelial cells from oxidative injury.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(13):4641-5.
1986: Lash L H; Elfarra A A; Anders M W
Renal cysteine conjugate beta-lyase. Bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane.
The Journal of biological chemistry 1986;261(13):5930-5.
1986: Lash L H; Jones D P
Purification and properties of the membranal thiol oxidase from porcine kidney.
Archives of biochemistry and biophysics 1986;247(1):120-30.
1986: Elfarra A A; Lash L H; Anders M W
Metabolic activation and detoxication of nephrotoxic cysteine and homocysteine S-conjugates.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(8):2667-71.
1986: Anders M W; Lash L H; Elfarra A A
Nephrotoxic amino acid and glutathione S-conjugates: formation and renal activation.
Advances in experimental medicine and biology 1986;197():443-55.
1985: Dohn D R; Leininger J R; Lash L H; Quebbemann A J; Anders M W
Nephrotoxicity of S-(2-chloro-1,1,2-trifluoroethyl)glutathione and S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine, the glutathione and cysteine conjugates of chlorotrifluoroethene.
The Journal of pharmacology and experimental therapeutics 1985;235(3):851-7.
1985: Lash L H; Jones D P
Uptake of the glutathione conjugate S-(1,2-dichlorovinyl)glutathione by renal basal-lateral membrane vesicles and isolated kidney cells.
Molecular pharmacology 1985;28(3):278-82.
1985: Lash L H; Jones D P
Distribution of oxidized and reduced forms of glutathione and cysteine in rat plasma.
Archives of biochemistry and biophysics 1985;240(2):583-92.
1984: Lash L H; Jones D P
Renal glutathione transport. Characteristics of the sodium-dependent system in the basal-lateral membrane.
The Journal of biological chemistry 1984;259(23):14508-14.
1984: Lash L H; Jones D P
Characteristics of cysteine uptake in intestinal basolateral membrane vesicles.
The American journal of physiology 1984;247(4 Pt 1):G394-401.
1984: Lash L H; Jones D P; Orrenius S
The renal thiol (glutathione) oxidase. Subcellular localization and properties.
Biochimica et biophysica acta 1984;779(2):191-200.
1983: Lash L H; Jones D P
Characterization of the membrane-associated thiol oxidase activity of rat small-intestinal epithelium.
Archives of biochemistry and biophysics 1983;225(1):344-52.
1983: Lash L H; Jones D P
Transport of glutathione by renal basal-lateral membrane vesicles.
Biochemical and biophysical research communications 1983;112(1):55-60.
1982: Lash L H; Jones D P
Localization of the membrane-associated thiol oxidase of rat kidney to the basal-lateral plasma membrane.
The Biochemical journal 1982;203(2):371-6.

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