David Latchman

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Barry Seán P; Townsend Paul A; McCormick James; Knight Richard A; Scarabelli Tiziano M; Latchman David S; Stephanou Anastasis
STAT3 deletion sensitizes cells to oxidative stress.
Sleiman P M A; Healy D G; Muqit M M K; Yang Y X; Van Der Brug M; Holton J L; Revesz T; Quinn N P; Bhatia K; Diss J K J; Lees A J; Cookson M R; Latchman D S; Wood N W
Characterisation of a novel NR4A2 mutation in Parkinson's disease brain.
Ioannou Y; Romay-Penabad Z; Pericleous C; Giles I; Papalardo E; Vargas G; Shilagard T; Latchman D S; Isenberg D A; Rahman A; Pierangeli S
In vivo inhibition of antiphospholipid antibody-induced pathogenicity utilizing the antigenic target peptide domain I of beta2-glycoprotein I: proof of concept.

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All Publications

2009: Barry Seán P; Townsend Paul A; McCormick James; Knight Richard A; Scarabelli Tiziano M; Latchman David S; Stephanou Anastasis
STAT3 deletion sensitizes cells to oxidative stress.
Biochemical and biophysical research communications 2009;385(3):324-9.
2009: Sleiman P M A; Healy D G; Muqit M M K; Yang Y X; Van Der Brug M; Holton J L; Revesz T; Quinn N P; Bhatia K; Diss J K J; Lees A J; Cookson M R; Latchman D S; Wood N W
Characterisation of a novel NR4A2 mutation in Parkinson's disease brain.
Neuroscience letters 2009;457(2):75-9.
2009: Ioannou Y; Romay-Penabad Z; Pericleous C; Giles I; Papalardo E; Vargas G; Shilagard T; Latchman D S; Isenberg D A; Rahman A; Pierangeli S
In vivo inhibition of antiphospholipid antibody-induced pathogenicity utilizing the antigenic target peptide domain I of beta2-glycoprotein I: proof of concept.
Journal of thrombosis and haemostasis : JTH 2009;7(5):833-42.
2009: Gandhi Sonia; Wood-Kaczmar Alison; Yao Zhi; Plun-Favreau Helene; Deas Emma; Klupsch Kristina; Downward Julian; Latchman David S; Tabrizi Sarah J; Wood Nicholas W; Duchen Michael R; Abramov Andrey Y
PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death.
Molecular cell 2009;33(5):627-38.
2009: Berwick Daniel C; Calissano Mattia; Corness Jacqueline D; Cook Simon J; Latchman David S
Regulation of Brn-3a N-terminal transcriptional activity by MEK1/2-ERK1/2 signalling in neural differentiation.
Brain research 2009;1256():8-18.
2009: Badin Romina A; Modo Michael; Cheetham Mike; Thomas David L; Gadian David G; Latchman David S; Lythgoe Mark F
Protective effect of post-ischaemic viral delivery of heat shock proteins in vivo.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(2):254-63.
2009: Yang Yan Xiang; Wood Nicholas W; Latchman David S
Molecular basis of Parkinson's disease.
Neuroreport 2009;20(2):150-6.
2009: Francis Yitshak I; Fà Mauro; Ashraf Haider; Zhang Hong; Staniszewski Agnieszka; Latchman David S; Arancio Ottavio
Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2009;18(1):131-9.
2008: Farooqui-Kabir Saleha R; Diss James K J; Henderson Deborah; Marber Michael S; Latchman David S; Budhram-Mahadeo Vishwanie; Heads Richard J
Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression.
Cell stress & chaperones 2008;13(3):297-312.
2008: Scarabelli Tiziano M; Townsend Paul A; Chen Scarabelli Carol; Yuan Zhaokan; McCauley Roy B; Di Rezze Justin; Patel David; Putt Jeff; Allebban Zuhair; Abboud John; Chilukuri Karuna; Gardin Julius; Saravolatz Louis; Knight Richard A; Latchman David S; Stephanou Anastasis
Amino acid supplementation differentially modulates STAT1 and STAT3 activation in the myocardium exposed to ischemia/reperfusion injury.
The American journal of cardiology 2008;101(11A):63E-68E.
2008: Soond Surinder M; Townsend Paul A; Barry Sean P; Knight Richard A; Latchman David S; Stephanou Anastasis
ERK and the F-box protein betaTRCP target STAT1 for degradation.
The Journal of biological chemistry 2008;283(23):16077-83.
2008: Yang Yan Xiang; Latchman David S
Nurr1 transcriptionally regulates the expression of alpha-synuclein.
Neuroreport 2008;19(8):867-71.
2008: Soond Surinder M; Barry Sean P; Melino Gerry; Knight Richard A; Latchman David S; Stephanou Anastasis
p73-mediated transcriptional activity is negatively regulated by polo-like kinase 1.
Cell cycle (Georgetown, Tex.) 2008;7(9):1214-23.
2008: Barry Seán P; Jayasinghe Suwan N; Pericleous Charis; Hubank Mike; Latchman David S; Stephanou Anastasis
Gene expression studies on bio-electrosprayed primary cardiac myocytes.
Biotechnology journal 2008;3(4):530-5.
2008: Sharp Paul S; Akbar Mohammed T; Bouri Sonia; Senda Atsushi; Joshi Kieran; Chen Han-Jou; Latchman David S; Wells Dominic J; de Belleroche Jacqueline
Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression.
Neurobiology of disease 2008;30(1):42-55.
2008: Diss James K J; Calissano Mattia; Gascoyne Duncan; Djamgoz Mustafa B A; Latchman David S
Identification and characterization of the promoter region of the Nav1.7 voltage-gated sodium channel gene (SCN9A).
Molecular and cellular neurosciences 2008;37(3):537-47.
2008: Budhram-Mahadeo V S; Irshad S; Bowen S; Lee S A; Samady L; Tonini G P; Latchman D S
Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells.
Oncogene 2008;27(1):145-54.
2007: Townsend Paul A; Davidson Sean M; Clarke Samantha J; Khaliulin Igor; Carroll Christopher J; Scarabelli Tiziano M; Knight Richard A; Stephanou Anastasis; Latchman David S; Halestrap Andrew P
Urocortin prevents mitochondrial permeability transition in response to reperfusion injury indirectly by reducing oxidative stress.
American journal of physiology. Heart and circulatory physiology 2007;293(2):H928-38.
2007: Lambrianides Anastasia; Giles Ian; Ioannou Yiannis; Mason Lesley; Latchman David S; Manson Jessica J; Isenberg David A; Rahman Anisur
Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome.
Arthritis and rheumatism 2007;56(7):2392-401.
2007: Calissano Mattia; Diss James K J; Latchman David S
Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells.
FEBS letters 2007;581(13):2490-6.
2007: Zourlidou Alexandra; Gidalevitz Tali; Kristiansen Mark; Landles Christian; Woodman Ben; Wells Dominic J; Latchman David S; de Belleroche Jackie; Tabrizi Sarah J; Morimoto Richard I; Bates Gillian P
Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation.
Human molecular genetics 2007;16(9):1078-90.
2007: Soond Surinder M; Carroll Christopher; Townsend Paul A; Sayan Emre; Melino Gerry; Behrmann Iris; Knight Richard A; Latchman David S; Stephanou Anastasis
STAT1 regulates p73-mediated Bax gene expression.
FEBS letters 2007;581(6):1217-26.
2007: Francis Yitshak I; Diss James K J; Kariti Moshe; Stephanou Anastasis; Latchman David S
p300 activation by Presenilin 1 but not by its M146L mutant.
Neuroscience letters 2007;413(2):137-40.
2007: Barry Seán P; Townsend Paul A; Latchman David S; Stephanou Anastasis
Role of the JAK-STAT pathway in myocardial injury.
Trends in molecular medicine 2007;13(2):82-9.
2007: Ioannou Yiannis; Pericleous Charis; Giles Ian; Latchman David S; Isenberg David A; Rahman Anisur
Binding of antiphospholipid antibodies to discontinuous epitopes on domain I of human beta(2)-glycoprotein I: mutation studies including residues R39 to R43.
Arthritis and rheumatism 2007;56(1):280-90.
2006: Lawrence K M; Latchman D S
The Urocortins: mechanisms of cardioprotection and therapeutic potential.
Mini reviews in medicinal chemistry 2006;6(10):1119-26.
2006: Abou-Sleiman Patrick M; Muqit Miratul M K; McDonald Neil Q; Yang Yan Xiang; Gandhi Sonia; Healy Daniel G; Harvey Kirsten; Harvey Robert J; Deas Emma; Bhatia Kailash; Quinn Niall; Lees Andrew; Latchman David S; Wood Nicholas W
A heterozygous effect for PINK1 mutations in Parkinson's disease?
Annals of neurology 2006;60(4):414-9.
2006: McCormick James; Barry Sean P; Sivarajah Ahila; Stefanutti Giorgio; Townsend Paul A; Lawrence Kevin M; Eaton Simon; Knight Richard A; Thiemermann Christoph; Latchman David S; Stephanou Anastasis
Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2115-7.
2006: Yang Yan Xiang; Muqit Miratul M K; Latchman David S
Induction of parkin expression in the presence of oxidative stress.
The European journal of neuroscience 2006;24(5):1366-72.
2006: Giles Ian; Lambrianides Nancy; Pattni Nisha; Faulkes David; Latchman David; Chen Pojen; Pierangeli Silvia; Isenberg David; Rahman Anisur
Arginine residues are important in determining the binding of human monoclonal antiphospholipid antibodies to clinically relevant antigens.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1729-36.
2006: Muqit Miratul M K; Abou-Sleiman Patrick M; Saurin Adrian T; Harvey Kirsten; Gandhi Sonia; Deas Emma; Eaton Simon; Payne Smith Martin D; Venner Kerrie; Matilla Antoni; Healy Daniel G; Gilks William P; Lees Andrew J; Holton Janice; Revesz Tamas; Parker Peter J; Harvey Robert J; Wood Nicholas W; Latchman David S
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress.
Journal of neurochemistry 2006;98(1):156-69.
2006: Francis Yitshak I; Stephanou Anastasis; Latchman David S
CREB-binding protein activation by presenilin 1 but not by its M146L mutant.
Neuroreport 2006;17(9):917-21.
2006: Valentim Lauren; Laurence Kevin M; Townsend Paul A; Carroll Christopher J; Soond Surinder; Scarabelli Tiziano M; Knight Richard A; Latchman David S; Stephanou Anastasis
Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury.
Journal of molecular and cellular cardiology 2006;40(6):846-52.
2006: Kabakov Alexander E; Malyutina Yana V; Latchman David S
Hsf1-mediated stress response can transiently enhance cellular radioresistance.
Radiation research 2006;165(4):410-23.
2006: Scarabelli Tiziano M; Knight Richard; Stephanou Anastasis; Townsend Paul; Chen-Scarabelli Carol; Lawrence Kevin; Gottlieb Roberta; Latchman David; Narula Jagat
Clinical implications of apoptosis in ischemic myocardium.
Current problems in cardiology 2006;31(3):181-264.
2006: Badin Romina Aron; Lythgoe Mark F; van der Weerd Louise; Thomas David L; Gadian David G; Latchman David S
Neuroprotective effects of virally delivered HSPs in experimental stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006;26(3):371-81.
2006: Budhram-Mahadeo Vishwanie S; Latchman David S
Targeting Brn-3b in breast cancer therapy.
Expert opinion on therapeutic targets 2006;10(1):15-25.
2006: Samady Laila; Faulkes David J; Budhram-Mahadeo Vishwanie; Ndisang Daniel; Potter Eyck; Brabant Georg; Latchman David S
The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells.
International journal of cancer. Journal international du cancer 2006;118(4):869-78.
2006: Ndisang D; Faulkes D J; Gascoyne D; Lee S A; Ripley B J; Sindos M; Singer A; Budhram-Mahadeo V; Cason J; Latchman D S
Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a.
Oncogene 2006;25(1):51-60.
2006: Smart Nicola; Mojet Mart H; Latchman David S; Marber Michael S; Duchen Michael R; Heads Richard J
IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes.
Cardiovascular research 2006;69(1):164-77.
2006: Ndisang Daniel; Lorenzato Felipe; Sindos Michael; Singer Albert; Latchman David S
Detection of cervical abnormalities in a developing country using measurement of Brn-3a in cervical smears.
Gynecologic oncology 2006;100(1):89-94.
2006: Budhram-Mahadeo Vishwanie S; Bowen Samantha; Lee Sonia; Perez-Sanchez Christina; Ensor Elizabeth; Morris Peter J; Latchman David S
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
Nucleic acids research 2006;34(22):6640-52.
2006: Soond Surinder M; Latchman David S; Stephanou Anastasis
STAT signalling in the heart and cardioprotection.
Expert reviews in molecular medicine 2006;8(15):1-16.
2006: Ioannou Yiannis; Giles Ian; Lambrianides Anastasia; Richardson Chris; Pearl Laurence H; Latchman David S; Isenberg David A; Rahman Anisur
A novel expression system of domain I of human beta2 glycoprotein I in Escherichia coli.
BMC biotechnology 2006;6():8.
2006: Diss J K J; Faulkes D J; Walker M M; Patel A; Foster C S; Budhram-Mahadeo V; Djamgoz M B A; Latchman D S
Brn-3a neuronal transcription factor functional expression in human prostate cancer.
Prostate cancer and prostatic diseases 2006;9(1):83-91.
2005: Calissano Mattia; Faulkes David; Latchman David S
Phosphorylation of the Brn-3a transcription factor is modulated during differentiation and regulates its functional activity.
Brain research. Molecular brain research 2005;141(1):10-8.
2005: Bandopadhyay Rina; Kingsbury Ann E; Muqit Miratul M; Harvey Kirsten; Reid Andrew R; Kilford Linda; Engelender Simone; Schlossmacher Michael G; Wood Nicholas W; Latchman David S; Harvey Robert J; Lees Andrew J
Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition.
Neurobiology of disease 2005;20(2):401-11.
2005: Latchman David S
Herpes simplex virus-based vectors for the treatment of cancer and neurodegenerative disease.
Current opinion in molecular therapeutics 2005;7(5):415-8.
2005: Stephanou A; Latchman D S
Opposing actions of STAT-1 and STAT-3.
Growth factors (Chur, Switzerland) 2005;23(3):177-82.
2005: van der Weerd Louise; Lythgoe Mark F; Badin Romina Aron; Valentim Lauren M; Akbar Mohammed Tariq; de Belleroche Jackie S; Latchman David S; Gadian David G
Neuroprotective effects of HSP70 overexpression after cerebral ischaemia--an MRI study.
Experimental neurology 2005;195(1):257-66.
2005: Fraser Scott P; Diss James K J; Chioni Athina-Myrto; Mycielska Maria E; Pan Huiyan; Yamaci Rezan F; Pani Filippo; Siwy Zuzanna; Krasowska Monika; Grzywna Zbigniew; Brackenbury William J; Theodorou Dimis; Koyutürk Meral; Kaya Handan; Battaloglu Esra; De Bella Manuela Tamburo; Slade Martin J; Tolhurst Robert; Palmieri Carlo; Jiang Jie; Latchman David S; Coombes R Charles; Djamgoz Mustafa B A
Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(15):5381-9.
2005: Chen-Scarabelli Carol; Hughes Siân E; Landon Giorgio; Rowley Peter; Allebban Zuhair; Lawson Noel; Saravolatz Louis; Gardin Julius; Latchman David; Scarabelli Tiziano M
A case of fatal ephedra intake associated with lipofuscin accumulation, caspase activation and cleavage of myofibrillary proteins.
European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology 2005;7(5):927-30.
2005: Collino Massimo; Patel Nimesh S A; Lawrence Kevin M; Collin Marika; Latchman David S; Yaqoob Muhammad M; Thiemermann Christoph
The selective PPARgamma antagonist GW9662 reverses the protection of LPS in a model of renal ischemia-reperfusion.
Kidney international 2005;68(2):529-36.
2005: Lawrence K M; Kabir A M N; Bellahcene M; Davidson S; Cao X B; McCormick J; Mesquita R A; Carroll C J; Chanalaris A; Townsend P A; Hubank M; Stephanou A; Knight R A; Marber M S; Latchman D S
Cardioprotection mediated by urocortin is dependent on PKCepsilon activation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(7):831-3.
2005: Patel Yogesh J K; Payne Smith Martin D; de Belleroche Jacqueline; Latchman David S
Hsp27 and Hsp70 administered in combination have a potent protective effect against FALS-associated SOD1-mutant-induced cell death in mammalian neuronal cells.
Brain research. Molecular brain research 2005;134(2):256-74.
2005: Lee Sonia A; Ndisang Daniel; Patel Chandrakant; Dennis Jonathan H; Faulkes David J; D'Arrigo Corrado; Samady Laila; Farooqui-Kabir Saleha; Heads Richard J; Latchman David S; Budhram-Mahadeo Vishwanie S
Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter.
Cancer research 2005;65(8):3072-80.
2005: Ripley B J M; Rahman M A; Isenberg D A; Latchman D S
Elevated expression of the Brn-3a and Brn-3b transcription factors in systemic lupus erythematosus correlates with antibodies to Brn-3 and overexpression of Hsp90.
Arthritis and rheumatism 2005;52(4):1171-9.
2005: Townsend Paul A; Cragg Mark S; Davidson Sean M; McCormick James; Barry Sean; Lawrence Kevin M; Knight Richard A; Hubank Michael; Chen Phang-Lang; Latchman David S; Stephanou Anastasis
STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage.
Journal of cell science 2005;118(Pt 8):1629-39.
2005: Kumar Sanjeev; Bunting Karen A; Kalsi Jatinderpal; Hinks John A; Latchman David S; Pearl Laurence H; Isenberg David A
Lupus autoantibodies to native DNA preferentially bind DNA presented on PolIV.
Immunology 2005;114(3):418-27.
2005: Chanalaris Anastasios; Lawrence Kevin M; Townsend Paul A; Davidson Sean; Jamshidi Yalda; Stephanou Anastasis; Knight Richard D; Hsu Sheau Y; Hsueh Aaron J W; Latchman David S
Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway.
Biochemical and biophysical research communications 2005;328(2):442-8.
2005: Hudson Chantelle D; Morris Peter J; Latchman David S; Budhram-Mahadeo Vishwanie S
Brn-3a transcription factor blocks p53-mediated activation of proapoptotic target genes Noxa and Bax in vitro and in vivo to determine cell fate.
The Journal of biological chemistry 2005;280(12):11851-8.
2005: Townsend Paul A; Stephanou Anastasis; Packham Graham; Latchman David S
BAG-1: a multi-functional pro-survival molecule.
The international journal of biochemistry & cell biology 2005;37(2):251-9.
2005: Davidson Sean M; Townsend Paul A; Carroll Chris; Yurek-George Alexander; Balasubramanyam Karanam; Kundu Tapas K; Stephanou Anastasis; Packham Graham; Ganesan A; Latchman David S
The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin.
Chembiochem : a European journal of chemical biology 2005;6(1):162-70.
2005: Kumar Sanjeev; Nagl Sylvia; Kalsi Jatinderpal K; Ravirajan Chelliah T; Athwal Dee; Latchman David S; Pearl Laurence H; Isenberg David A
Beta-2-glycoprotein specificity of human anti-phospholipid antibody resides on the light chain: a novel mechanism for acquisition of cross-reactivity by an autoantibody.
Molecular immunology 2005;42(1):39-48.
2005: Mason Lesley J; Lambrianides Anastasia; Haley Joanna D; Manson Jessica J; Latchman David S; Isenberg David A; Rahman Anisur
Stable expression of a recombinant human antinucleosome antibody to investigate relationships between antibody sequence, binding properties, and pathogenicity.
Arthritis research & therapy 2005;7(5):R971-83.
2005: Giles Ian; Lambrianides Nancy; Latchman David; Chen Pojen; Chukwuocha Reginald; Isenberg David; Rahman Anisur
The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin.
Arthritis research & therapy 2005;7(1):R47-56.
2004: Kabakov A E; Budagova K R; Malyutina Y V; Latchman D S; Csermely P
Pharmacological attenuation of apoptosis in reoxygenated endothelial cells.
Cellular and molecular life sciences : CMLS 2004;61(24):3076-86.
2004: Munarriz Eliana; Barcaroli Daniela; Stephanou Anastasis; Townsend Paul A; Maisse Carine; Terrinoni Alessandro; Neale Michael H; Martin Seamus J; Latchman David S; Knight Richard A; Melino Gerry; De Laurenzi Vincenzo
PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73.
Molecular and cellular biology 2004;24(24):10593-610.
2004: Hudson Chantelle D; Podesta Jennifer; Henderson Deborah; Latchman D S; Budhram-Mahadeo V
Coexpression of Brn-3a POU protein with p53 in a population of neuronal progenitor cells is associated with differentiation and protection against apoptosis.
Journal of neuroscience research 2004;78(6):803-14.
2004: Farooqui-Kabir S R; Budhram-Mahadeo V; Lewis H; Latchman D S; Marber M S; Heads R J
Regulation of Hsp27 expression and cell survival by the POU transcription factor Brn3a.
Cell death and differentiation 2004;11(11):1242-4.
2004: MacCormac Luci P; Muqit Miratul M K; Faulkes David J; Wood Nicholas W; Latchman David S
Reduction in endogenous parkin levels renders glial cells sensitive to both caspase-dependent and caspase-independent cell death.
The European journal of neuroscience 2004;20(8):2038-48.
2004: Townsend Paul A; Scarabelli Tiziano M; Pasini Evasio; Gitti Gianluca; Menegazzi Marta; Suzuki Hisanori; Knight Richard A; Latchman David S; Stephanou Anastasis
Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(13):1621-3.
2004: Scarabelli Tiziano M; Pasini Evasio; Ferrari Gianna; Ferrari Mario; Stephanou Anastasis; Lawrence Kevin; Townsend Paul; Chen-Scarabelli Carol; Gitti Gianluca; Saravolatz Louis; Latchman David; Knight Richard A; Gardin Julius M
Warm blood cardioplegic arrest induces mitochondrial-mediated cardiomyocyte apoptosis associated with increased urocortin expression in viable cells.
The Journal of thoracic and cardiovascular surgery 2004;128(3):364-71.
2004: Lawrence Kevin M; Townsend Paul A; Davidson Sean M; Carroll Christopher J; Eaton Simon; Hubank Mike; Knight Richard A; Stephanou Anastasis; Latchman David S
The cardioprotective effect of urocortin during ischaemia/reperfusion involves the prevention of mitochondrial damage.
Biochemical and biophysical research communications 2004;321(2):479-86.
2004: Kumar Sanjeev; Kalsi Jatinderpal; Bunting Karen; Ravirajan Chelliah T; Latchman David S; Pearl Laurence H; Isenberg David A
Fine binding characteristics of human autoantibodies-partial molecular characterization.
Molecular immunology 2004;41(5):495-510.
2004: Faulkes David J; Ensor Elizabeth; Le Rouzic Erwan; Latchman David S
Distinct domains of Brn-3a regulate apoptosis and neurite outgrowth in vivo.
Neuroreport 2004;15(9):1421-5.
2004: Thomas G R; Faulkes D J; Gascoyne D; Latchman D S
EWS differentially activates transcription of the Brn-3a long and short isoform mRNAs from distinct promoters.
Biochemical and biophysical research communications 2004;318(4):1045-51.
2004: Parkinson E J; Townsend P A; Stephanou A; Latchman D S; Eaton S; Pierro A
The protective effect of moderate hypothermia during intestinal ischemia-reperfusion is associated with modification of hepatic transcription factor activation.
Journal of pediatric surgery 2004;39(5):696-701.
2004: Valente Enza Maria; Abou-Sleiman Patrick M; Caputo Viviana; Muqit Miratul M K; Harvey Kirsten; Gispert Suzana; Ali Zeeshan; Del Turco Domenico; Bentivoglio Anna Rita; Healy Daniel G; Albanese Alberto; Nussbaum Robert; González-Maldonado Rafael; Deller Thomas; Salvi Sergio; Cortelli Pietro; Gilks William P; Latchman David S; Harvey Robert J; Dallapiccola Bruno; Auburger Georg; Wood Nicholas W
Hereditary early-onset Parkinson's disease caused by mutations in PINK1.
Science (New York, N.Y.) 2004;304(5674):1158-60.
2004: Gascoyne Duncan M; Thomas G Ruth; Latchman David S
The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1.
Oncogene 2004;23(21):3830-40.
2004: Gusterson Rosalind J; Yuan L Wuchao; Latchman David S
Distinct serine residues in CBP and p300 are necessary for their activation by phenylephrine.
The international journal of biochemistry & cell biology 2004;36(5):893-9.
2004: Townsend Paul A; Cutress Ramsey I; Carroll Christopher J; Lawrence Kevin M; Scarabelli Tiziano M; Packham Graham; Stephanou Anastasis; Latchman David S
BAG-1 proteins protect cardiac myocytes from simulated ischemia/reperfusion-induced apoptosis via an alternate mechanism of cell survival independent of the proteasome.
The Journal of biological chemistry 2004;279(20):20723-8.
2004: Irshad Shazia; Pedley R Barbara; Anderson John; Latchman David S; Budhram-Mahadeo Vishwanie
The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo.
The Journal of biological chemistry 2004;279(20):21617-27.
2004: Scarabelli Tiziano M; Pasini Evasio; Stephanou Anastasis; Chen-Scarabelli Carol; Saravolatz Louis; Knight Richard A; Latchman David S; Gardin Julius M
Nutritional supplementation with mixed essential amino acids enhances myocyte survival, preserving mitochondrial functional capacity during ischemia-reperfusion injury.
The American journal of cardiology 2004;93(8A):35A-40A.
2004: Ravirajan C T; Wang Y; Matis L A; Papadaki L; Griffiths M H; Latchman D S; Isenberg D A
Effect of neutralizing antibodies to IL-10 and C5 on the renal damage caused by a pathogenic human anti-dsDNA antibody.
Rheumatology (Oxford, England) 2004;43(4):442-7.
2004: Alsbury Sam; Papageorgiou Konstantina; Latchman David S
Heat shock proteins can protect aged human and rodent cells from different stressful stimuli.
Mechanisms of ageing and development 2004;125(3):201-9.
2004: Jamshidi Y; Zourlidou A; Carroll C J; Sinclair J; Latchman D S
Signal-transduction pathways involved in the hypertrophic effect of hsp56 in neonatal cardiomyocytes.
Journal of molecular and cellular cardiology 2004;36(3):381-92.
2004: Zourlidou Alexandra; Payne Smith Martin D; Latchman David S
HSP27 but not HSP70 has a potent protective effect against alpha-synuclein-induced cell death in mammalian neuronal cells.
Journal of neurochemistry 2004;88(6):1439-48.
2004: Scarabelli Tiziano M; Stephanou Anastasis; Pasini Evasio; Gitti Gianluca; Townsend Paul; Lawrence Kevin; Chen-Scarabelli Carol; Saravolatz Louis; Latchman David; Knight Richard; Gardin Julius
Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO.
Journal of the American College of Cardiology 2004;43(5):865-74.
2004: Samady Laila; Dennis Jonathan; Budhram-Mahadeo Vishwanie; Latchman David S
Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor.
Cancer biology & therapy 2004;3(3):317-23.
2004: Townsend Paul A; Scarabelli Tiziano M; Davidson Sean M; Knight Richard A; Latchman David S; Stephanou Anastasis
STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis.
The Journal of biological chemistry 2004;279(7):5811-20.
2004: Latchman David S
Protective effect of heat shock proteins in the nervous system.
Current neurovascular research 2004;1(1):21-7.
2004: Haley Joanna; Mason Lesley J; Nagl Sylvia; Giles Ian; Latchman David S; Isenberg David A; Rahman Anisur
Somatic mutations to arginine residues affect the binding of human monoclonal antibodies to DNA, histones, SmD and Ro antigen.
Molecular immunology 2004;40(11):745-58.
2004: Muqit Miratul M K; Davidson Sean M; Payne Smith Martin D; MacCormac Luci P; Kahns Soren; Jensen Poul H; Wood Nicholas W; Latchman David S
Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival.
Human molecular genetics 2004;13(1):117-35.
2004: Brar Bhawanjit K; Jonassen Anne K; Egorina Elena M; Chen Alon; Negro Alejandra; Perrin Marilyn H; Mjøs Ole D; Latchman David S; Lee Kuo-Fen; Vale Wylie
Urocortin-II and urocortin-III are cardioprotective against ischemia reperfusion injury: an essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart.
Endocrinology 2004;145(1):24-35; discussion 21-3.
2004: West D A; Valentim L M; Lythgoe M F; Stephanou A; Proctor E; van der Weerd L; Ordidge R J; Latchman D S; Gadian D G
MR image-guided investigation of regional signal transducers and activators of transcription-1 activation in a rat model of focal cerebral ischemia.
Neuroscience 2004;127(2):333-9.
2003: Stephanou Anastasis; Latchman David S
STAT-1: a novel regulator of apoptosis.
International journal of experimental pathology 2003;84(6):239-44.
2003: Lawrence K M; Scarabelli T M; Turtle L; Chanalaris A; Townsend P A; Carroll C J; Hubank M; Stephanou A; Knight R A; Latchman D S
Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium-insensitive phospholipase A2 gene expression.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(15):2313-5.
2003: Kumar Sanjeev; Nagl Sylvia; Kalsi J K; Ravirajan C T; Athwal Dee; Latchman David S; Pearl Laurence H; Isenberg David A
Anti-cardiolipin/beta-2 glycoprotein activities co-exist on human anti-DNA antibody light chains.
Molecular immunology 2003;40(8):517-30.
2003: Davidson Sean M; Stephanou Anastasis; Latchman David S
FLIP protects cardiomyocytes from apoptosis induced by simulated ischemia/reoxygenation, as demonstrated by short hairpin-induced (shRNA) silencing of FLIP mRNA.
Journal of molecular and cellular cardiology 2003;35(11):1359-64.
2003: Ensor Elizabeth; Mathews Karen; Payne Smith Martin D; Latchman David S
Sensory neurons from mice lacking the Brn-3b POU family transcription factor are resistant to death-inducing stimuli both in vitro and in vivo.
Brain research. Molecular brain research 2003;117(2):206-12.
2003: Chanalaris A; Lawrence K M; Stephanou A; Knight R D; Hsu S Y; Hsueh A J W; Latchman D S
Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes.
Journal of molecular and cellular cardiology 2003;35(10):1295-305.
2003: Giles Ian P; Haley Joanna; Nagl Sylvia; Latchman David S; Chen Pojen P; Chukwuocha Reginald U; Isenberg David A; Rahman Anisur
Relative importance of different human aPL derived heavy and light chains in the binding of aPL to cardiolipin.
Molecular immunology 2003;40(1):49-60.
2003: Calissano M; Latchman D S
Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor.
Oncogene 2003;22(35):5408-14.
2003: Giles Ian P; Isenberg David A; Latchman David S; Rahman Anisur
How do antiphospholipid antibodies bind beta2-glycoprotein I?
Arthritis and rheumatism 2003;48(8):2111-21.
2003: Hargitai Judit; Lewis Hannah; Boros Imre; Rácz Tímea; Fiser András; Kurucz István; Benjamin Ivor; Vígh László; Pénzes Zoltán; Csermely Péter; Latchman David S
Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1.
Biochemical and biophysical research communications 2003;307(3):689-95.
2003: Sindos Michael; Ndisang Daniel; Pisal Narendra; Chow Carl; Singer Albert; Latchman David S
Measurement of Brn-3a levels in Pap smears provides a novel diagnostic marker for the detection of cervical neoplasia.
Gynecologic oncology 2003;90(2):366-71.
2003: Sindos M; Ndisang D; Pisal N; Chow C; Deery A; Singer A; Latchman D
Detection of cervical neoplasia using measurement of Brn-3a in cervical smears with persistent minor abnormality.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2003;13(4):515-7.
2003: Mason M R J; Lieberman A R; Latchman D S; Anderson P N
FKBP12 mRNA expression is upregulated by intrinsic CNS neurons regenerating axons into peripheral nerve grafts in the brain.
Experimental neurology 2003;181(2):181-9.
2003: Akbar Mohammed T; Lundberg Anna M C; Liu Ke; Vidyadaran Sharmili; Wells Kim E; Dolatshad Hamid; Wynn Sarah; Wells Dominic J; Latchman David S; de Belleroche Jacqueline
The neuroprotective effects of heat shock protein 27 overexpression in transgenic animals against kainate-induced seizures and hippocampal cell death.
The Journal of biological chemistry 2003;278(22):19956-65.
2003: Zourlidou Alexandra; Payne Smith Martin D; Latchman David S
Modulation of cell death by alpha-synuclein is stimulus-dependent in mammalian cells.
Neuroscience letters 2003;340(3):234-8.
2003: Chanalaris A; Sun Y; Latchman D S; Stephanou A
SAG attenuates apoptotic cell death caused by simulated ischaemia/reoxygenation in rat cardiomyocytes.
Journal of molecular and cellular cardiology 2003;35(3):257-64.
2003: Kalwy Stephan A; Akbar Mohammed T; Coffin Robert S; de Belleroche Jacqueline; Latchman David S
Heat shock protein 27 delivered via a herpes simplex virus vector can protect neurons of the hippocampus against kainic-acid-induced cell loss.
Brain research. Molecular brain research 2003;111(1-2):91-103.
2003: Samady Laila; Costigliola Emanuela; MacCormac Luci; McGrath Yvonne; Cleverley Steve; Lilley Caroline E; Smith Jill; Latchman David S; Chain Benny; Coffin Robert S
Deletion of the virion host shutoff protein (vhs) from herpes simplex virus (HSV) relieves the viral block to dendritic cell activation: potential of vhs- HSV vectors for dendritic cell-mediated immunotherapy.
Journal of virology 2003;77(6):3768-76.
2003: Giles Ian P; Haley Joanna D; Nagl Sylvia; Isenberg David A; Latchman David S; Rahman Anisur
A systematic analysis of sequences of human antiphospholipid and anti-beta2-glycoprotein I antibodies: the importance of somatic mutations and certain sequence motifs.
Seminars in arthritis and rheumatism 2003;32(4):246-65.
2003: Gusterson Rosalind J; Jazrawi Elen; Adcock Ian M; Latchman David S
The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity.
The Journal of biological chemistry 2003;278(9):6838-47.
2003: Kabakov Alexander E; Budagova Karina R; Bryantsev Anton L; Latchman David S
Heat shock protein 70 or heat shock protein 27 overexpressed in human endothelial cells during posthypoxic reoxygenation can protect from delayed apoptosis.
Cell stress & chaperones 2003;8(4):335-47.
2003: Janjua Sadia; Lawrence Kevin M; Ng Leong L; Latchman David S
The cardioprotective agent urocortin induces expression of CT-1.
Cardiovascular toxicology 2003;3(3):255-62.
2003: Latchman David S
Herpes simplex virus vectors for Parkinson's disease.
International review of neurobiology 2003;55():223-41.
2002: Patel Yogesh; Collaco Moraes Yolanda; Latchman David; Coffin Robert; de Belleroche Jacqueline
Neuroprotective effects of copper/zinc-dependent superoxide dismutase against a wide variety of death-inducing stimuli and proapoptotic effect of familial amyotrophic lateral sclerosis mutations.
Brain research. Molecular brain research 2002;109(1-2):189-97.
2002: Latchman David S
Herpes simplex virus vectors for gene delivery to a variety of different cell types.
Current gene therapy 2002;2(4):415-26.
2002: Budhram-Mahadeo Vishwanie; Morris Peter; Ndisang Daniel; Irshad Shazia; Lozano Guilermina; Pedley Barbara; Latchman David S
The Brn-3a POU family transcription factor stimulates p53 gene expression in human and mouse tumour cells.
Neuroscience letters 2002;334(1):1-4.
2002: Papageorgiou Konstantina; Isenberg David A; Latchman David S
Optimisation of herpes simplex virus-based vectors for delivery to human peripheral blood mononuclear cells.
Journal of immunological methods 2002;270(2):235-46.
2002: Perez-Sanchez C; Budhram-Mahadeo V S; Latchman D S
Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter.
Nucleic acids research 2002;30(22):4872-80.
2002: Stephanou Anastasis; Scarabelli Tiziano M; Townsend Paul A; Bell Robert; Yellon Derek; Knight Richard A; Latchman David S
The carboxyl-terminal activation domain of the STAT-1 transcription factor enhances ischemia/reperfusion-induced apoptosis in cardiac myocytes.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(13):1841-3.
2002: Schulman Daniel; Latchman David S; Yellon Derek M
Urocortin protects the heart from reperfusion injury via upregulation of p42/p44 MAPK signaling pathway.
American journal of physiology. Heart and circulatory physiology 2002;283(4):H1481-8.
2002: Janjua S; Stephanou A; Latchman D S
The C-terminal activation domain of the STAT-1 transcription factor is necessary and sufficient for stress-induced apoptosis.
Cell death and differentiation 2002;9(10):1140-6.
2002: Storey Nina; Latchman David; Bevan Stuart
Selective internalization of sodium channels in rat dorsal root ganglion neurons infected with herpes simplex virus-1.
The Journal of cell biology 2002;158(7):1251-62.
2002: Lawrence K M; Chanalaris A; Scarabelli T; Hubank M; Pasini E; Townsend P A; Comini L; Ferrari R; Tinker A; Stephanou A; Knight R A; Latchman D S
K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect.
Circulation 2002;106(12):1556-62.
2002: Budram-Mahadeo Vishwanie; Morris Peter J; Latchman David S
The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1).
Oncogene 2002;21(39):6123-31.
2002: Saurin Adrian T; Pennington Daniel J; Raat Nicolaas J H; Latchman David S; Owen Michael J; Marber Michael S
Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts.
Cardiovascular research 2002;55(3):672-80.
2002: Kabakov Alexander E; Budagova Karina R; Latchman David S; Kampinga Harm H
Stressful preconditioning and HSP70 overexpression attenuate proteotoxicity of cellular ATP depletion.
American journal of physiology. Cell physiology 2002;283(2):C521-34.
2002: Latchman David S
Urocortin.
The international journal of biochemistry & cell biology 2002;34(8):907-10.
2002: Thomas G Ruth; Latchman David S
The pro-oncoprotein EWS (Ewing's Sarcoma protein) interacts with the Brn-3a POU transcription factor and inhibits its ability to activate transcription.
Cancer biology & therapy 2002;1(4):428-32.
2002: Scarabelli Tiziano M; Pasini Evasio; Stephanou Anastasis; Comini Laura; Curello Salvatore; Raddino Riccardo; Ferrari Roberto; Knight Richard; Latchman David S
Urocortin promotes hemodynamic and bioenergetic recovery and improves cell survival in the isolated rat heart exposed to ischemia/reperfusion.
Journal of the American College of Cardiology 2002;40(1):155-61.
2002: Dennis Jonathan H; Budhram-Mahadeo Vishwanie; Latchman David S
Functional interaction between Brn-3a and Src-1 co-activates Brn-3a-mediated transactivation.
Biochemical and biophysical research communications 2002;294(2):487-95.
2002: Brar Bhawanjit K; Stephanou Anastasis; Knight Richard; Latchman David S
Activation of protein kinase B/Akt by urocortin is essential for its ability to protect cardiac cells against hypoxia/reoxygenation-induced cell death.
Journal of molecular and cellular cardiology 2002;34(4):483-92.
2002: Scarabelli Tiziano M; Stephanou Anastasis; Pasini Evasio; Comini Laura; Raddino Riccardo; Knight Richard A; Latchman David S
Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury.
Circulation research 2002;90(6):745-8.
2002: Thomas S K; Lilley C E; Latchman D S; Coffin R S
A protein encoded by the herpes simplex virus (HSV) type 1 2-kilobase latency-associated transcript is phosphorylated, localized to the nucleus, and overcomes the repression of expression from exogenous promoters when inserted into the quiescent HSV genome.
Journal of virology 2002;76(8):4056-67.
2002: Stephanou Anastasis; Scarabelli Tiziano M; Knight Richard A; Latchman David S
Antiapoptotic activity of the free caspase recruitment domain of procaspase-9: a novel endogenous rescue pathway in cell death.
The Journal of biological chemistry 2002;277(16):13693-9.
2002: Railson Julia E; Liao Zhihong; Brar Bhawanjit K; Buddle Joanna C; Pennica Diane; Stephanou Anastasis; Latchman David S
Cardiotrophin-1 and urocortin cause protection by the same pathway and hypertrophy via distinct pathways in cardiac myocytes.
Cytokine 2002;17(5):243-53.
2002: Liao Zhihong; Brar Bhawanjit K; Cai Qing; Stephanou Anastasis; O'Leary Rhona M; Pennica Diane; Yellon Derek M; Latchman David S
Cardiotrophin-1 (CT-1) can protect the adult heart from injury when added both prior to ischaemia and at reperfusion.
Cardiovascular research 2002;53(4):902-10.
2002: Brar B K; Railson J; Stephanou A; Knight R A; Latchman D S
Urocortin increases the expression of heat shock protein 90 in rat cardiac myocytes in a MEK1/2-dependent manner.
The Journal of endocrinology 2002;172(2):283-93.
2002: Gusterson Rosalind; Brar Bhawanjit; Faulkes David; Giordano Antonio; Chrivia John; Latchman David
The transcriptional co-activators CBP and p300 are activated via phenylephrine through the p42/p44 MAPK cascade.
The Journal of biological chemistry 2002;277(4):2517-24.
2002: Kumar S; Kalsi J K; Ravirajan C T; Latchman D S; Pearl L H; Isenberg D A
Molecular expression systems for anti-DNA antibodies--2.
Lupus 2002;11(12):833-42.
2002: Rahman A; Haley J; Latchman D S
Molecular expression systems for anti-DNA antibodies--1.
Lupus 2002;11(12):824-32.
2002: Latchman David S
Protection of neuronal and cardiac cells by HSP27.
Progress in molecular and subcellular biology 2002;28():253-65.
2001: Wright M J; Wightman L M; Latchman D S; Marber M S
In vivo myocardial gene transfer: optimization and evaluation of intracoronary gene delivery in vivo.
Gene therapy 2001;8(24):1833-9.
2001: Ripley B J; Isenberg D A; Latchman D S
Elevated levels of the 90 kDa heat shock protein (hsp90) in SLE correlate with levels of IL-6 and autoantibodies to hsp90.
Journal of autoimmunity 2001;17(4):341-6.
2001: Latchman D S
Gene therapy with herpes simplex virus vectors: progress and prospects for clinical neuroscience.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2001;7(6):528-37.
2001: Brar B K; Stephanou A; Pennica D; Latchman D S
CT-1 mediated cardioprotection against ischaemic re-oxygenation injury is mediated by PI3 kinase, Akt and MEK1/2 pathways.
Cytokine 2001;16(3):93-6.
2001: Sugars K L; Budhram-Mahadeo V; Packham G; Latchman D S
A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53.
Nucleic acids research 2001;29(22):4530-40.
2001: Smith M D; Ensor E A; Kinloch R A; Latchman D S
The POU domain transcription factor Brn-3a protects cortical neurons from apoptosis.
Neuroreport 2001;12(15):3183-8.
2001: Mason L J; Ravirajan C T; Latchman D S; Isenberg D A
A human anti-dsDNA monoclonal antibody caused hyaline thrombi formation in kidneys of 'leaky' SCID mice.
Clinical and experimental immunology 2001;126(1):137-42.
2001: Schulman D; Latchman D S; Yellon D M
Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury.
American journal of physiology. Heart and circulatory physiology 2001;281(4):H1630-6.
2001: Budhram-Mahadeo V; Moore A; Morris P J; Ward T; Weber B; Sassone-Corsi P; Latchman D S
The closely related POU family transcription factors Brn-3a and Brn-3b are expressed in distinct cell types in the testis.
The international journal of biochemistry & cell biology 2001;33(10):1027-39.
2001: Akbar M T; Wells D J; Latchman D S; de Belleroche J
Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration.
Brain research. Molecular brain research 2001;93(2):148-63.
2001: Latchman D S
Heat shock proteins and cardiac protection.
Cardiovascular research 2001;51(4):637-46.
2001: Dennis J H; Budhram-Mahadeo V; Latchman D S
The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells.
Oncogene 2001;20(36):4961-71.
2001: Ndisang D; Budhram-Mahadeo V; Pedley B; Latchman D S
The Brn-3a transcription factor plays a key role in regulating the growth of cervical cancer cells in vivo.
Oncogene 2001;20(35):4899-903.
2001: Freeland K; Boxer L M; Latchman D S
The cyclic AMP response element in the Bcl-2 promoter confers inducibility by hypoxia in neuronal cells.
Brain research. Molecular brain research 2001;92(1-2):98-106.
2001: Brar B K; Stephanou A; Liao Z; O'Leary R M; Pennica D; Yellon D M; Latchman D S
Cardiotrophin-1 can protect cardiac myocytes from injury when added both prior to simulated ischaemia and at reoxygenation.
Cardiovascular research 2001;51(2):265-74.
2001: Latchman D S
Urocortin protects against ischemic injury via a MAPK-dependent pathway.
Trends in cardiovascular medicine 2001;11(5):167-9.
2001: Scarabelli T; Stephanou A; Rayment N; Pasini E; Comini L; Curello S; Ferrari R; Knight R; Latchman D
Apoptosis of endothelial cells precedes myocyte cell apoptosis in ischemia/reperfusion injury.
Circulation 2001;104(3):253-6.
2001: Stephanou A; Scarabelli T M; Brar B K; Nakanishi Y; Matsumura M; Knight R A; Latchman D S
Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701.
The Journal of biological chemistry 2001;276(30):28340-7.
2001: Railson J E; Lawrence K; Buddle J C; Pennica D; Latchman D S
Heat shock protein-56 is induced by cardiotrophin-1 and mediates its hypertrophic effect.
Journal of molecular and cellular cardiology 2001;33(6):1209-21.
2001: Wright M J; Wightman L M; Lilley C; de Alwis M; Hart S L; Miller A; Coffin R S; Thrasher A; Latchman D S; Marber M S
In vivo myocardial gene transfer: optimization, evaluation and direct comparison of gene transfer vectors.
Basic research in cardiology 2001;96(3):227-36.
2001: Kumar S; Kalsi J; Latchman D S; Pearl L H; Isenberg D A
Expression of the Fabs of human auto-antibodies in Escherichia coli: optimization and determination of their fine binding characteristics and cross-reactivity.
Journal of molecular biology 2001;308(3):527-39.
2001: Lilley C E; Groutsi F; Han Z; Palmer J A; Anderson P N; Latchman D S; Coffin R S
Multiple immediate-early gene-deficient herpes simplex virus vectors allowing efficient gene delivery to neurons in culture and widespread gene delivery to the central nervous system in vivo.
Journal of virology 2001;75(9):4343-56.
2001: Smith M D; Melton L A; Ensor E A; Packham G; Anderson P; Kinloch R A; Latchman D S
Brn-3a activates the expression of Bcl-x(L) and promotes neuronal survival in vivo as well as in vitro.
Molecular and cellular neurosciences 2001;17(3):460-70.
2001: Rahman A; Haley J; Radway-Bright E; Nagl S; Low D G; Latchman D S; Isenberg D A
The importance of somatic mutations in the V(lambda) gene 2a2 in human monoclonal anti-DNA antibodies.
Journal of molecular biology 2001;307(1):149-60.
2001: Latchman D S
Gene delivery and gene therapy with herpes simplex virus-based vectors.
Gene 2001;264(1):1-9.
2001: Ensor E; Smith M D; Latchman D S
The BRN-3A transcription factor protects sensory but not sympathetic neurons from programmed cell death/apoptosis.
The Journal of biological chemistry 2001;276(7):5204-12.
2000: Railson J; Lawrence K; Stephanou A; Brar B; Pennica D; Latchman D
Cardiotrophin-1 reduces stress-induced heat shock protein production in cardiac myocytes.
Cytokine 2000;12(11):1741-4.
2000: Kumar S; Kalsi J; Ravirajan C T; Rahman A; Athwal D; Latchman D S; Isenberg D A; Pearl L H
Molecular cloning and expression of the Fabs of human autoantibodies in Escherichia coli. Determination of the heavy or light chain contribution to the anti-DNA/-cardiolipin activity of the Fab.
The Journal of biological chemistry 2000;275(45):35129-36.
2000: Latchman D S
Gene therapy using herpes simplex virus-based vectors.
Histology and histopathology 2000;15(4):1253-9.
2000: Mockridge J W; Punn A; Latchman D S; Marber M S; Heads R J
PKC-dependent delayed metabolic preconditioning is independent of transient MAPK activation.
American journal of physiology. Heart and circulatory physiology 2000;279(2):H492-501.
2000: Mockridge J W; Benton E C; Andreeva L V; Latchman D S; Marber M S; Heads R J
IGF-1 regulates cardiac fibroblast apoptosis induced by osmotic stress.
Biochemical and biophysical research communications 2000;273(1):322-7.
2000: Palmer J A; Branston R H; Lilley C E; Robinson M J; Groutsi F; Smith J; Latchman D S; Coffin R S
Development and optimization of herpes simplex virus vectors for multiple long-term gene delivery to the peripheral nervous system.
Journal of virology 2000;74(12):5604-18.
2000: Ndisang D; Budhram-Mahadeo V; Singer A; Latchman D S
Widespread elevated expression of the human papilloma virus (HPV)-activating cellular transcription factor Brn-3a in the cervix of women with CIN3 (cervical intraepithelial neoplasia stage 3).
Clinical science (London, England : 1979) 2000;98(5):601-2.
2000: Jonassen A K; Brar B K; Mjøs O D; Sack M N; Latchman D S; Yellon D M
Insulin administered at reoxygenation exerts a cardioprotective effect in myocytes by a possible anti-apoptotic mechanism.
Journal of molecular and cellular cardiology 2000;32(5):757-64.
2000: Stephanou A; Brar B K; Scarabelli T M; Jonassen A K; Yellon D M; Marber M S; Knight R A; Latchman D S
Ischemia-induced STAT-1 expression and activation play a critical role in cardiomyocyte apoptosis.
The Journal of biological chemistry 2000;275(14):10002-8.
2000: Brar B K; Jonassen A K; Stephanou A; Santilli G; Railson J; Knight R A; Yellon D M; Latchman D S
Urocortin protects against ischemic and reperfusion injury via a MAPK-dependent pathway.
The Journal of biological chemistry 2000;275(12):8508-14.
2000: Latchman D S; Coffin R S
Viral vectors in the treatment of Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2000;15(1):9-17.
2000: Freeland K; Liu Y Z; Latchman D S
Distinct signalling pathways mediate the cAMP response element (CRE)-dependent activation of the calcitonin gene-related peptide gene promoter by cAMP and nerve growth factor.
The Biochemical journal 2000;345 Pt 2():233-8.
1999: Latchman D S
Herpes virus vectors for gene therapy in the nervous system.
Biochemical Society transactions 1999;27(6):847-51.
1999: Smith M D; Ensor E A; Stohl L; Wagner J A; Latchman D S
Regulation of NGFI-A (Egr-1) gene expression by the POU domain transcription factor Brn-3a.
Brain research. Molecular brain research 1999;74(1-2):117-25.
1999: Brar B K; Stephanou A; Okosi A; Lawrence K M; Knight R A; Marber M S; Latchman D S
CRH-like peptides protect cardiac myocytes from lethal ischaemic injury.
Molecular and cellular endocrinology 1999;158(1-2):55-63.
1999: Latchman D S
Herpes simplex virus vectors for gene therapy in Parkinson's disease and other diseases of the nervous system.
Journal of the Royal Society of Medicine 1999;92(11):566-70.
1999: Budhram-Mahadeo V; Ndisang D; Ward T; Weber B L; Latchman D S
The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cells.
Oncogene 1999;18(48):6684-91.
1999: Ndisang D; Budhram-Mahadeo V; Latchman D S
The Brn-3a transcription factor plays a critical role in regulating human papilloma virus gene expression and determining the growth characteristics of cervical cancer cells.
The Journal of biological chemistry 1999;274(40):28521-7.
1999: Thomas S K; Lilley C E; Latchman D S; Coffin R S
Equine herpesvirus 1 gene 12 can substitute for vmw65 in the growth of herpes simplex virus (HSV) type 1, allowing the generation of optimized cell lines for the propagation of HSV vectors with multiple immediate-early gene defects.
Journal of virology 1999;73(9):7399-409.
1999: Latchman D S
Cardiotrophin-1 (CT-1): a novel hypertrophic and cardioprotective agent.
International journal of experimental pathology 1999;80(4):189-96.
1999: Scarabelli T M; Knight R A; Rayment N B; Cooper T J; Stephanou A; Brar B K; Lawrence K M; Santilli G; Latchman D S; Baxter G F; Yellon D M
Quantitative assessment of cardiac myocyte apoptosis in tissue sections using the fluorescence-based tunel technique enhanced with counterstains.
Journal of immunological methods 1999;228(1-2):23-8.
1999: Rahman A; Latchman D; Isenberg D
Sequence features of monoclonal antiphospholipid antibodies: comment on the article by Ikematsu et al.
Arthritis and rheumatism 1999;42(8):1783-4.
1999: Thomas S K; Gough G; Latchman D S; Coffin R S
Herpes simplex virus latency-associated transcript encodes a protein which greatly enhances virus growth, can compensate for deficiencies in immediate-early gene expression, and is likely to function during reactivation from virus latency.
Journal of virology 1999;73(8):6618-25.
1999: Ripley B J; Stephanou A; Isenberg D A; Latchman D S
Interleukin-10 activates heat-shock protein 90beta gene expression.
Immunology 1999;97(2):226-31.
1999: Dollery C M; Humphries S E; McClelland A; Latchman D S; McEwan J R
In vivo adenoviral gene transfer of TIMP-1 after vascular injury reduces neointimal formation.
Annals of the New York Academy of Sciences 1999;878():742-3.
1999: Dollery C M; Humphries S E; McClelland A; Latchman D S; McEwan J R
Expression of tissue inhibitor of matrix metalloproteinases 1 by use of an adenoviral vector inhibits smooth muscle cell migration and reduces neointimal hyperplasia in the rat model of vascular balloon injury.
Circulation 1999;99(24):3199-205.
1999: Budhram-Mahadeo V; Morris P J; Smith M D; Midgley C A; Boxer L M; Latchman D S
p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor.
The Journal of biological chemistry 1999;274(21):15237-44.
1999: Liu Y Z; Boxer L M; Latchman D S
Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade.
Nucleic acids research 1999;27(10):2086-90.
1999: Latchman D S
POU family transcription factors in the nervous system.
Journal of cellular physiology 1999;179(2):126-33.
1999: Liu Y Z; Thomas N S; Latchman D S
CBP associates with the p42/p44 MAPK enzymes and is phosphorylated following NGF treatment.
Neuroreport 1999;10(6):1239-43.
1999: Brownlees J; Gough G; Thomas S; Watts P; Cohen J; Coffin R; Latchman D S
Distinct responses of the herpes simplex virus and varicella zoster virus immediate early promoters to the cellular transcription factors Brn-3a and Brn-3b.
The international journal of biochemistry & cell biology 1999;31(3-4):451-61.
1999: Wagstaff M J; Collaço-Moraes Y; Smith J; de Belleroche J S; Coffin R S; Latchman D S
Protection of neuronal cells from apoptosis by Hsp27 delivered with a herpes simplex virus-based vector.
The Journal of biological chemistry 1999;274(8):5061-9.
1999: Latchman D S
Regulation of DNA virus transcription by cellular POU family transcription factors.
Reviews in medical virology 1999;9(1):31-8.
1999: Brar B K; Stephanou A; Wagstaff M J; Coffin R S; Marber M S; Engelmann G; Latchman D S
Heat shock proteins delivered with a virus vector can protect cardiac cells against apoptosis as well as against thermal or hypoxic stress.
Journal of molecular and cellular cardiology 1999;31(1):135-46.
1999: Stephanou A; Isenberg D A; Nakajima K; Latchman D S
Signal transducer and activator of transcription-1 and heat shock factor-1 interact and activate the transcription of the Hsp-70 and Hsp-90beta gene promoters.
The Journal of biological chemistry 1999;274(3):1723-8.
1999: Latchman D S
Gene therapy with herpes simplex virus vectors.
Archivum immunologiae et therapiae experimentalis 1999;47(6):335-40.
1999: Stephanou A; Latchman D S
Transcriptional regulation of the heat shock protein genes by STAT family transcription factors.
Gene expression 1999;7(4-6):311-9.
1998: Coffin R S; Thomas S K; Thomas D P; Latchman D S
The herpes simplex virus 2 kb latency associated transcript (LAT) leader sequence allows efficient expression of downstream proteins which is enhanced in neuronal cells: possible function of LAT ORFs.
The Journal of general virology 1998;79 ( Pt 12)():3019-26.
1998: Gay R D; Dawson S J; Murphy W J; Russell S W; Latchman D S
Activation of the iNOS gene promoter by Brn-3 POU family transcription factors is dependent upon the octamer motif in the promoter.
Biochimica et biophysica acta 1998;1443(3):315-22.
1998: Rahman M A; Kettleborough C A; Latchman D S; Isenberg D A
Properties of whole human IgG molecules produced by the expression of cloned anti-DNA antibody cDNA in mammalian cells.
Journal of autoimmunity 1998;11(6):661-9.
1998: Stephanou A; Latchman D S; Isenberg D A
The regulation of heat shock proteins and their role in systemic lupus erythematosus.
Seminars in arthritis and rheumatism 1998;28(3):155-62.
1998: Rahman A; Latchman D S; Isenberg D A
Immunoglobulin variable region sequences of human monoclonal anti-DNA antibodies.
Seminars in arthritis and rheumatism 1998;28(3):141-54.
1998: Liu Y Z; Chrivia J C; Latchman D S
Nerve growth factor up-regulates the transcriptional activity of CBP through activation of the p42/p44(MAPK) cascade.
The Journal of biological chemistry 1998;273(49):32400-7.
1998: Wagstaff M J; Lilley C E; Smith J; Robinson M J; Coffin R S; Latchman D S
Gene transfer using a disabled herpes virus vector containing the EMCV IRES allows multiple gene expression in vitro and in vivo.
Gene therapy 1998;5(11):1566-70.
1998: Chapman C M; Latchman D S
The different alternatively spliced isoforms of the Oct-2 transcription factor repress the involucrin promoter in a cell type-specific manner.
Molecular biology reports 1998;25(4):253-7.
1998: Latchman D S
The Brn-3a transcription factor.
The international journal of biochemistry & cell biology 1998;30(11):1153-7.
1998: Wagstaff M J; Smith J; Collaco-Moraes Y; de Belleroche J S; Voellmy R; Coffin R S; Latchman D S
Delivery of a constitutively active form of the heat shock factor using a virus vector protects neuronal cells from thermal or ischaemic stress but not from apoptosis.
The European journal of neuroscience 1998;10(11):3343-50.
1998: Rahman A; Latchman D S; Isenberg D A
The role of in vitro expression systems in the investigation of antibodies to DNA.
Seminars in arthritis and rheumatism 1998;28(2):130-9.
1998: Smith M D; Dawson S J; Boxer L M; Latchman D S
The N-terminal domain unique to the long form of the Brn-3a transcription factor is essential to protect neuronal cells from apoptosis and for the activation of Bbcl-2 gene expression.
Nucleic acids research 1998;26(18):4100-7.
1998: Zhao J; Renner O; Wightman L; Sugden P H; Stewart L; Miller A D; Latchman D S; Marber M S
The expression of constitutively active isotypes of protein kinase C to investigate preconditioning.
The Journal of biological chemistry 1998;273(36):23072-9.
1998: Howard M K; Kershaw T; Gibb B; Storey N; MacLean A R; Zeng B Y; Tel B C; Jenner P; Brown S M; Woolf C J; Anderson P N; Coffin R S; Latchman D S
High efficiency gene transfer to the central nervous system of rodents and primates using herpes virus vectors lacking functional ICP27 and ICP34.5.
Gene therapy 1998;5(8):1137-47.
1998: Dawson S J; Palmer R D; Morris P J; Latchman D S
Functional role of position 22 in the homeodomain of Brn-3 transcription factors.
Neuroreport 1998;9(10):2305-9.
1998: Smith M D; Ensor E A; Coffin R S; Boxer L M; Latchman D S
Bcl-2 transcription from the proximal P2 promoter is activated in neuronal cells by the Brn-3a POU family transcription factor.
The Journal of biological chemistry 1998;273(27):16715-22.
1998: Stephanou A; Conroy S; Isenberg D A; Maione D; Poli V; Ciliberto G; Latchman D S
Elevation of IL-6 in transgenic mice results in increased levels of the 90 kDa heat shock protein (hsp90) and the production of anti-hsp90 antibodies.
Journal of autoimmunity 1998;11(3):249-53.
1998: Conroy S E; Sasieni P D; Amin V; Wang D Y; Smith P; Fentiman I S; Latchman D S
Antibodies to heat-shock protein 27 are associated with improved survival in patients with breast cancer.
British journal of cancer 1998;77(11):1875-9.
1998: Coffin R S; Thomas S K; Thomas N S; Lilley C E; Pizzey A R; Griffiths C H; Gibb B J; Wagstaff M J; Inges S J; Binks M H; Chain B M; Thrasher A J; Rutault K; Latchman D S
Pure populations of transduced primary human cells can be produced using GFP expressing herpes virus vectors and flow cytometry.
Gene therapy 1998;5(5):718-22.
1998: Patel Y; Gough G; Coffin R S; Thomas S; Cohen J I; Latchman D S
Cell type specific repression of the varicella zoster virus immediate early gene 62 promoter by the cellular Oct-2 transcription factor.
Biochimica et biophysica acta 1998;1397(3):268-74.
1998: Liu Y Z; Lee I K; Locke I; Dawson S J; Latchman D S
Adjacent proline residues in the inhibitory domain of the Oct-2 transcription factor play distinct functional roles.
Nucleic acids research 1998;26(10):2464-72.
1998: Okosi A; Brar B K; Chan M; D'Souza L; Smith E; Stephanou A; Latchman D S; Chowdrey H S; Knight R A
Expression and protective effects of urocortin in cardiac myocytes.
Neuropeptides 1998;32(2):167-71.
1998: Stephanou A; Brar B; Heads R; Knight R D; Marber M S; Pennica D; Latchman D S
Cardiotrophin-1 induces heat shock protein accumulation in cultured cardiac cells and protects them from stressful stimuli.
Journal of molecular and cellular cardiology 1998;30(4):849-55.
1998: Wyatt S; Ensor L; Begbie J; Ernfors P; Reichardt L F; Latchman D S
NT-3 regulates expression of Brn3a but not Brn3b in developing mouse trigeminal sensory neurons.
Brain research. Molecular brain research 1998;55(2):254-64.
1998: Ndisdang D; Morris P J; Chapman C; Ho L; Singer A; Latchman D S
The HPV-activating cellular transcription factor Brn-3a is overexpressed in CIN3 cervical lesions.
The Journal of clinical investigation 1998;101(8):1687-92.
1998: Thomas S; Coffin R S; Watts P; Gough G; Latchman D S
The TAATGARAT motif in the herpes simplex virus immediate-early gene promoters can confer both positive and negative responses to cellular octamer-binding proteins when it is located within the viral genome.
Journal of virology 1998;72(4):3495-500.
1998: Wright M J; Rosenthal E; Stewart L; Wightman L M; Miller A D; Latchman D S; Marber M S
beta-Galactosidase staining following intracoronary infusion of cationic liposomes in the in vivo rabbit heart is produced by microinfarction rather than effective gene transfer: a cautionary tale.
Gene therapy 1998;5(3):301-8.
1998: Smith M D; Morris P J; Latchman D S
The Brn-3c transcription factor contains a neuronal-specific activation domain.
Neuroreport 1998;9(5):851-6.
1998: Stephanou A; Isenberg D A; Akira S; Kishimoto T; Latchman D S
The nuclear factor interleukin-6 (NF-IL6) and signal transducer and activator of transcription-3 (STAT-3) signalling pathways co-operate to mediate the activation of the hsp90beta gene by interleukin-6 but have opposite effects on its inducibility by heat shock.
The Biochemical journal 1998;330 ( Pt 1)():189-95.
1998: Budhram-Mahadeo V; Parker M; Latchman D S
POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element.
Molecular and cellular biology 1998;18(2):1029-41.
1998: Ravirajan C T; Rahman M A; Papadaki L; Griffiths M H; Kalsi J; Martin A C; Ehrenstein M R; Latchman D S; Isenberg D A
Genetic, structural and functional properties of an IgG DNA-binding monoclonal antibody from a lupus patient with nephritis.
European journal of immunology 1998;28(1):339-50.
1997: Latchman D S
Transcription factors: an overview.
The international journal of biochemistry & cell biology 1997;29(12):1305-12.
1997: Deans Z C; Dawson S J; Kilimann M W; Wallace D; Wilson M C; Latchman D S
Differential regulation of genes encoding synaptic proteins by the Oct-2 transcription factor.
Brain research. Molecular brain research 1997;51(1-2):1-7.
1997: Howard M K; Coffin R S; Maclean A R; Brown S M; Bailey D; Anderson P N; Burnstock G; Latchman D S
Gene delivery to rat enteric neurons using herpes simplex virus-based vectors.
Journal of molecular neuroscience : MN 1997;9(2):65-74.
1997: Stephanou A; Okosi A; Knight R A; Chowdrey H S; Latchman D S
C/EBP activates the human corticotropin-releasing hormone gene promoter.
Molecular and cellular endocrinology 1997;134(1):41-50.
1997: Gay R D; Dawson S J; Latchman D S
The different inhibitory domains of the Oct-2 transcription factor have distinct functional activities.
FEBS letters 1997;416(2):135-8.
1997: Smith M D; Morris P J; Dawson S J; Schwartz M L; Schlaepfer W W; Latchman D S
Coordinate induction of the three neurofilament genes by the Brn-3a transcription factor.
The Journal of biological chemistry 1997;272(34):21325-33.
1997: Morris P J; Dawson S J; Wilson M C; Latchman D S
A single residue within the homeodomain of the Brn-3 POU family transcription factors determines whether they activate or repress the SNAP-25 promoter.
Neuroreport 1997;8(8):2041-5.
1997: Menon S; Rahman M A; Ravirajan C T; Kandiah D; Longhurst C M; McNally T; Williams W M; Latchman D S; Isenberg D A
The production, binding characteristics and sequence analysis of four human IgG monoclonal antiphospholipid antibodies.
Journal of autoimmunity 1997;10(1):43-57.
1997: Liu Y Z; Latchman D S
The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat.
The Biochemical journal 1997;322 ( Pt 1)():155-8.
1997: Stephanou A; Amin V; Isenberg D A; Akira S; Kishimoto T; Latchman D S
Interleukin 6 activates heat-shock protein 90 beta gene expression.
The Biochemical journal 1997;321 ( Pt 1)():103-6.
1997: Smith M D; Dawson S J; Latchman D S
Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor.
The Journal of biological chemistry 1997;272(2):1382-8.
1997: Smith M D; Dawson S J; Latchman D S
The Brn-3a transcription factor induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins.
Molecular and cellular biology 1997;17(1):345-54.
1997: Rose L M; Latchman D S; Isenberg D A
Elevated soluble fas production in SLE correlates with HLA status not with disease activity.
Lupus 1997;6(9):717-22.
1996: Morris P J; Lakin N D; Dawson S J; Ryabinin A E; Kilimann M W; Wilson M C; Latchman D S
Differential regulation of genes encoding synaptic proteins by members of the Brn-3 subfamily of POU transcription factors.
Brain research. Molecular brain research 1996;43(1-2):279-85.
1996: Wagstaff M J; Collaço-Moraes Y; Aspey B S; Coffin R S; Harrison M J; Latchman D S; de Belleroche J S
Focal cerebral ischaemia increases the levels of several classes of heat shock proteins and their corresponding mRNAs.
Brain research. Molecular brain research 1996;42(2):236-44.
1996: Cumming D V; Heads R J; Watson A; Latchman D S; Yellon D M
Differential protection of primary rat cardiocytes by transfection of specific heat stress proteins.
Journal of molecular and cellular cardiology 1996;28(12):2343-9.
1996: Deans Z; Dawson S J; Xie J; Young A P; Wallace D; Latchman D S
Differential regulation of the two neuronal nitric-oxide synthase gene promoters by the Oct-2 transcription factor.
The Journal of biological chemistry 1996;271(50):32153-8.
1996: Galea-Lauri J; Richardson A J; Latchman D S; Katz D R
Increased heat shock protein 90 (hsp90) expression leads to increased apoptosis in the monoblastoid cell line U937 following induction with TNF-alpha and cycloheximide: a possible role in immunopathology.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(9):4109-18.
1996: Latchman D S
The Oct-2 transcription factor.
The international journal of biochemistry & cell biology 1996;28(10):1081-3.
1996: Coffin R S; MacLean A R; Latchman D S; Brown S M
Gene delivery to the central and peripheral nervous systems of mice using HSV1 ICP34.5 deletion mutant vectors.
Gene therapy 1996;3(10):886-91.
1996: Liu Y Z; Lania L; Latchman D S
Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor.
AIDS (London, England) 1996;10(12):1323-9.
1996: Latchman D S
Inhibitory transcription factors.
The international journal of biochemistry & cell biology 1996;28(9):965-74.
1996: Cumming D V; Heads R J; Coffin R S; Yellon D M; Latchman D S
Pharmacological preconditioning of primary rat cardiac myocytes by FK506.
Basic research in cardiology 1996;91(5):367-73.
1996: Conroy S E; Latchman D S
Do heat shock proteins have a role in breast cancer?
British journal of cancer 1996;74(5):717-21.
1996: Smith M D; Latchman D S
The functionally antagonistic POU family transcription factors Brn-3a and Brn-3b show opposite changes in expression during the growth arrest and differentiation of human neuroblastoma cells.
International journal of cancer. Journal international du cancer 1996;67(5):653-60.
1996: Galea-Lauri J; Latchman D S; Katz D R
The role of the 90-kDa heat shock protein in cell cycle control and differentiation of the monoblastoid cell line U937.
Experimental cell research 1996;226(2):243-54.
1996: Liu Y Z; Dawson S J; Gerster T; Friedl E; Pengue G; Matthias P; Lania L; Latchman D S
The ability of the inhibitory domain of the POU family transcription factor Oct-2 to interfere with promoter activation by different classes of activation domains is dependent upon the nature of the basal promoter elements.
The Journal of biological chemistry 1996;271(34):20853-60.
1996: Kendall G; Crankson H; Ensor E; Lublin D M; Latchman D S
Activation of the gene encoding decay accelerating factor following nerve growth factor treatment of sensory neurons is mediated by promoter sequences within 206 bases of the transcriptional start site.
Journal of neuroscience research 1996;45(2):96-103.
1996: Coffin R S; Howard M K; Cumming D V; Dollery C M; McEwan J; Yellon D M; Marber M S; MacLean A R; Brown S M; Latchman D S
Gene delivery to the heart in vivo and to cardiac myocytes and vascular smooth muscle cells in vitro using herpes virus vectors.
Gene therapy 1996;3(7):560-6.
1996: Wyatt S; Mailhos C; Latchman D S
Trigeminal ganglion neurons are protected by the heat shock proteins hsp70 and hsp90 from thermal stress but not from programmed cell death following nerve growth factor withdrawal.
Brain research. Molecular brain research 1996;39(1-2):52-6.
1996: Milton N G; Bessis A; Changeux J P; Latchman D S
Differential regulation of neuronal nicotinic acetylcholine receptor subunit gene promoters by Brn-3 POU family transcription factors.
The Biochemical journal 1996;317 ( Pt 2)():419-23.
1996: Dawson S J; Morris P J; Latchman D S
A single amino acid change converts an inhibitory transcription factor into an activator.
The Journal of biological chemistry 1996;271(20):11631-3.
1996: Grenfell S J; Latchman D S; Thomas N S
Oct-1 [corrected] and Oct-2 DNA-binding site specificity is regulated in vitro by different kinases.
The Biochemical journal 1996;315 ( Pt 3)():889-93.
1996: Latchman D S
Activation and repression of gene expression by POU family transcription factors.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1339):511-5.
1996: Begbie J L; Wood J N; Anderson P N; Latchman D S
Specific up-regulation of the POU domain transcription factor Oct-2 following axotomy.
Neuroscience letters 1996;207(3):183-6.
1996: Budhram-Mahadeo V; Morris P J; Lakin N D; Dawson S J; Latchman D S
The different activities of the two activation domains of the Brn-3a transcription factor are dependent on the context of the binding site.
The Journal of biological chemistry 1996;271(15):9108-13.
1996: Amin V; Cumming D V; Latchman D S
Over-expression of heat shock protein 70 protects neuronal cells against both thermal and ischaemic stress but with different efficiencies.
Neuroscience letters 1996;206(1):45-8.
1996: Dawson S J; Liu Y Z; Rodel B; Möröy T; Latchman D S
The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements.
The Biochemical journal 1996;314 ( Pt 2)():439-43.
1996: Kendall G; Ensor E; Crankson H D; Latchman D S
Nerve growth factor treatment of sensory neuron primary cultures causes elevated levels of the mRNA encoding the ATP synthase beta-subunit as detected by a novel PCR-based differential cloning method.
European journal of biochemistry / FEBS 1996;236(2):360-4.
1996: Ensor E; Kendall G; Allchorne A; Woolf C J; Latchman D S
Induction of the Oct-2 transcription factor in primary sensory neurons during inflammation is nerve growth factor-dependent.
Neuroscience letters 1996;204(1-2):29-32.
1996: Morris S D; Cumming D V; Latchman D S; Yellon D M
Specific induction of the 70-kD heat stress proteins by the tyrosine kinase inhibitor herbimycin-A protects rat neonatal cardiomyocytes. A new pharmacological route to stress protein expression?
The Journal of clinical investigation 1996;97(3):706-12.
1996: Conroy S E; Tucker L; Latchman D S; Isenberg D A
Incidence of anti Hsp 90 and 70 antibodies in children with SLE, juvenile dermatomyositis and juvenile chronic arthritis.
Clinical and experimental rheumatology 1996;14(1):99-104.
1996: Cumming D V; Heads R J; Brand N J; Yellon D M; Latchman D S
The ability of heat stress and metabolic preconditioning to protect primary rat cardiac myocytes.
Basic research in cardiology 1996;91(1):79-85.
1996: Liu Y Z; Dawson S J; Latchman D S
Alternative splicing of the Brn-3a and Brn-3b transcription factor RNAs is regulated in neuronal cells.
Journal of molecular neuroscience : MN 1996;7(1):77-85.
1996: Heads R J; Latchman D S; Yellon D M
The molecular basis of adaptation to ischemia in the heart: the role of stress proteins and anti-oxidants in the ischemic and reperfused heart.
EXS 1996;76():383-407.
1995: Amin V; Cumming D V; Coffin R S; Latchman D S
The degree of protection provided to neuronal cells by a pre-conditioning stress correlates with the amount of heat shock protein 70 it induces and not with the similarity of the subsequent stress.
Neuroscience letters 1995;200(2):85-8.
1995: Heads R J; Latchman D S; Yellon D M
Differential stress protein mRNA expression during early ischaemic preconditioning in the rabbit heart and its relationship to adenosine receptor function.
Journal of molecular and cellular cardiology 1995;27(10):2133-48.
1995: Kalsi J K; Ravirajan C T; Wiloch-Winska H; Blanco F; Longhurst C M; Williams W; Chapman C; Hillson J; Youniou P; Latchman D
Analysis of three new idiotypes on human monoclonal autoantibodies.
Lupus 1995;4(5):375-89.
1995: Heads R J; Yellon D M; Latchman D S
Differential cytoprotection against heat stress or hypoxia following expression of specific stress protein genes in myogenic cells.
Journal of molecular and cellular cardiology 1995;27(8):1669-78.
1995: Lakin N D; Morris P J; Theil T; Sato T N; Möröy T; Wilson M C; Latchman D S
Regulation of neurite outgrowth and SNAP-25 gene expression by the Brn-3a transcription factor.
The Journal of biological chemistry 1995;270(26):15858-63.
1995: Milton N G; Bessis A; Changeux J P; Latchman D S
The neuronal nicotinic acetylcholine receptor alpha 2 subunit gene promoter is activated by the Brn-3b POU family transcription factor and not by Brn-3a or Brn-3c.
The Journal of biological chemistry 1995;270(25):15143-7.
1995: Coffin R S; Howard M K; Latchman D S
Altered dinucleotide content within the latently transcribed regions of the DNA of alpha herpes viruses--implications for latent RNA expression and DNA structure.
Virology 1995;209(2):358-65.
1995: Rose L M; Latchman D S; Isenberg D A
Bcl-2 expression is unaltered in unfractionated peripheral blood mononuclear cells in patients with systemic lupus erythematosus.
British journal of rheumatology 1995;34(4):316-20.
1995: Lillycrop K A; Liu Y Z; Theil T; Möröy T; Latchman D S
Activation of the herpes simplex virus immediate-early gene promoters by neuronally expressed POU family transcription factors.
The Biochemical journal 1995;307 ( Pt 2)():581-4.
1995: Watson A; Latchman D
The cyclic AMP response element in the calcitonin/calcitonin gene-related peptide gene promoter is necessary but not sufficient for its activation by nerve growth factor.
The Journal of biological chemistry 1995;270(16):9655-60.
1995: Watson A; Ensor E; Symes A; Winter J; Kendall G; Latchman D
A minimal CGRP gene promoter is inducible by nerve growth factor in adult rat dorsal root ganglion neurons but not in PC12 phaeochromocytoma cells.
The European journal of neuroscience 1995;7(3):394-400.
1995: Budhram-Mahadeo V; Morris P J; Lakin N D; Theil T; Ching G Y; Lillycrop K A; Möröy T; Liem R K; Latchman D S
Activation of the alpha-internexin promoter by the Brn-3a transcription factor is dependent on the N-terminal region of the protein.
The Journal of biological chemistry 1995;270(6):2853-8.
1995: Kendall G; Brar-Rai A; Ensor E; Winter J; Wood J N; Latchman D S
Nerve growth factor induces the Oct-2 transcription factor in sensory neurons with the kinetics of an immediate-early gene.
Journal of neuroscience research 1995;40(2):169-76.
1995: Budhram-Mahadeo V; Lillycrop K A; Latchman D S
The levels of the antagonistic POU family transcription factors Brn-3a and Brn-3b in neuronal cells are regulated in opposite directions by serum growth factors.
Neuroscience letters 1995;185(1):48-51.
1995: Liu Y Z; Lillycrop K A; Latchman D S
Regulated splicing of the Oct-2 transcription factor RNA in neuronal cells.
Neuroscience letters 1995;183(1-2):8-12.
1995: Lakin N D; Palmer R; Lillycrop K A; Howard M K; Burke L C; Thomas N S; Latchman D S
Down regulation of the octamer binding protein Oct-1 during growth arrest and differentiation of a neuronal cell line.
Brain research. Molecular brain research 1995;28(1):47-54.
1995: Deans Z; Dawson S J; Buttery L; Polak J M; Wallace D; Latchman D S
Direct evidence that the POU family transcription factor Oct-2 represses the cellular tyrosine hydroxylase gene in neuronal cells.
Journal of molecular neuroscience : MN 1995;6(3):159-67.
1995: Lillycrop K A; Latchman D S
The inhibitory domain in the Oct-2 transcription factor represses gene activity in a cell type-specific and promoter-independent manner.
Molecular biology reports 1995;21(2):87-94.
1994: Lillycrop K A; Dawson S J; Estridge J K; Gerster T; Matthias P; Latchman D S
Repression of a herpes simplex virus immediate-early promoter by the Oct-2 transcription factor is dependent on an inhibitory region at the N terminus of the protein.
Molecular and cellular biology 1994;14(11):7633-42.
1994: Mailhos C; Howard M K; Latchman D S
Heat shock proteins hsp90 and hsp70 protect neuronal cells from thermal stress but not from programmed cell death.
Journal of neurochemistry 1994;63(5):1787-95.
1994: Morris P J; Theil T; Ring C J; Lillycrop K A; Moroy T; Latchman D S
The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain.
Molecular and cellular biology 1994;14(10):6907-14.
1994: Conroy S E; Faulds G B; Williams W; Latchman D S; Isenberg D A
Detection of autoantibodies to the 90 kDa heat shock protein in systemic lupus erythematosus and other autoimmune diseases.
British journal of rheumatology 1994;33(10):923-6.
1994: Latchman D S
Herpes simplex virus vectors for gene therapy.
Molecular biotechnology 1994;2(2):179-95.
1994: Budhram-Mahadeo V; Theil T; Morris P J; Lillycrop K A; Moroy T; Latchman D S
The DNA target site for the Brn-3 POU family transcription factors can confer responsiveness to cyclic AMP and removal of serum in neuronal cells.
Nucleic acids research 1994;22(15):3092-8.
1994: Kendall G; Ensor E; Brar-Rai A; Winter J; Latchman D S
Nerve growth factor induces expression of immediate-early genes NGFI-A (Egr-1) and NGFI-B (nur 77) in adult rat dorsal root ganglion neurons.
Brain research. Molecular brain research 1994;25(1-2):73-9.
1994: Huntriss J D; Barr J A; Horn D A; Williams D G; Latchman D S
Mice lacking Snrpn expression show normal regulation of neuronal alternative splicing events.
Molecular biology reports 1994;20(1):19-25.
1994: Gerrelli D; Huntriss J D; Latchman D S
Antagonistic effects of retinoic acid and thyroid hormone on the expression of the tissue-specific splicing protein SmN in a clonal cell line derived from rat heart.
Journal of molecular and cellular cardiology 1994;26(6):713-9.
1994: Heads R J; Latchman D S; Yellon D M
Stable high level expression of a transfected human HSP70 gene protects a heart-derived muscle cell line against thermal stress.
Journal of molecular and cellular cardiology 1994;26(6):695-9.
1994: Dhillon V B; McCallum S; Latchman D S; Isenberg D A
Elevation of the 90 kDa heat-shock protein in specific subsets of systemic lupus erythematosus.
The Quarterly journal of medicine 1994;87(4):215-22.
1994: Ehrenstein M R; Longhurst C M; Latchman D S; Isenberg D A
Serological and genetic characterization of a human monoclonal immunoglobulin G anti-DNA idiotype.
The Journal of clinical investigation 1994;93(4):1787-97.
1994: Mailhos C; Howard M K; Latchman D S
A common pathway mediates retinoic acid and PMA-dependent programmed cell death (apoptosis) of neuronal cells.
Brain research 1994;644(1):7-12.
1994: Lillycrop K A; Howard M K; Estridge J K; Latchman D S
Inhibition of herpes simplex virus infection by ectopic expression of neuronal splice variants of the Oct-2 transcription factor.
Nucleic acids research 1994;22(5):815-20.
1994: Marber M S; Walker J M; Latchman D S; Yellon D M
Myocardial protection after whole body heat stress in the rabbit is dependent on metabolic substrate and is related to the amount of the inducible 70-kD heat stress protein.
The Journal of clinical investigation 1994;93(3):1087-94.
1994: Dawson S J; Yoon S O; Chikaraishi D M; Lillycrop K A; Latchman D S
The Oct-2 transcription factor represses tyrosine hydroxylase expression via a heptamer TAATGARAT-like motif in the gene promoter.
Nucleic acids research 1994;22(6):1023-8.
1994: Lillycrop K A; Estridge J K; Latchman D S
Functional interaction between different isoforms of the Oct-2 transcription factor expressed in neuronal cells.
The Biochemical journal 1994;298 ( Pt 1)():245-8.
1994: Blanco F; Longhurst C; Watts R; Kalsi J; Wiloch H W; Youinou P; Latchman D S; Isenberg D A
Identification and characterization of a new human DNA reactive monoclonal antibody and a common idiotype, WRI 176 Id beta.
Lupus 1994;3(1):15-24.
1994: Budhram-Mahadeo V; Lillycrop K A; Latchman D S
Cell cycle arrest and morphological differentiation can occur in the absence of apoptosis in a neuronal cell line.
Neuroscience letters 1994;165(1-2):18-22.
1994: Latchman D S
Regulation of viral and cellular gene expression in sensory neurons.
Gene therapy 1994;1 Suppl 1():S25-7.
1994: Huntriss J D; Twomey B M; Isenberg D A; Latchman D S
Enhanced transcription of the gene encoding the SmN autoantigen in patients with systemic lupus erythematosus does not result in enhanced levels of the SmN protein.
Autoimmunity 1994;19(2):81-7.
1994: Latchman D S; Isenberg D A
The role of hsp90 in SLE.
Autoimmunity 1994;19(3):211-8.
1994: Rose L M; Latchman D S; Isenberg D A
Bcl-2 and Fas, molecules which influence apoptosis. A possible role in systemic lupus erythematosus?
Autoimmunity 1994;17(4):271-8.
1993: Stevenson F K; Longhurst C; Chapman C J; Ehrenstein M; Spellerberg M B; Hamblin T J; Ravirajan C T; Latchman D; Isenberg D
Utilization of the VH4-21 gene segment by anti-DNA antibodies from patients with systemic lupus erythematosus.
Journal of autoimmunity 1993;6(6):809-25.
1993: Dhillon V; McCallum S; Wilks D; Twomey B; Latchman D; Isenberg D
The differential expression of heat shock proteins in rheumatic disease.
British journal of rheumatology 1993;32(10):883-92.
1993: Lillycrop K A; Estridge J K; Latchman D S
The octamer binding protein Oct-2 inhibits transactivation of the herpes simplex virus immediate-early genes by the virion protein Vmw65.
Virology 1993;196(2):888-91.
1993: Twomey B M; Amin V; Isenberg D A; Latchman D S
Elevated levels of the 70 kD heat shock protein in patients with systemic lupus erythematosus are not dependent on enhanced transcription of the hsp70 gene.
Lupus 1993;2(5):297-301.
1993: Marber M S; Latchman D S; Walker J M; Yellon D M
Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.
Circulation 1993;88(3):1264-72.
1993: Marber M S; Walker J M; Latchman D S; Yellon D M
Attenuation by heat stress of a submaximal calcium paradox in the rabbit heart.
Journal of molecular and cellular cardiology 1993;25(9):1119-26.
1993: Morris P J; Ring C J; Lillycrop K A; Latchman D S
Transactivation of the human papilloma virus 16 octamer motif by the octamer binding protein Oct-2 requires both the N and C terminal activation domains.
Nucleic acids research 1993;21(19):4506-10.
1993: Mailhos C; Howard M K; Latchman D S
Heat shock protects neuronal cells from programmed cell death by apoptosis.
Neuroscience 1993;55(3):621-7.
1993: Horn D A; Latchman D S
The tissue specific SmN protein does not influence the alternative splicing of endogenous N-Cam and C-SRC RNAs in transfected 3T3 cells.
Brain research. Molecular brain research 1993;19(3):181-7.
1993: Twomey B M; McCallum S; Isenberg D A; Latchman D S
Elevation of heat shock protein synthesis and hsp gene transcription during monocyte to macrophage differentiation of U937 cells.
Clinical and experimental immunology 1993;93(2):178-83.
1993: Twomey B M; Dhillon V B; McCallum S; Isenberg D A; Latchman D S
Elevated levels of the 90 kD heat shock protein in patients with systemic lupus erythematosus are dependent upon enhanced transcription of the hsp90 beta gene.
Journal of autoimmunity 1993;6(4):495-506.
1993: Howard M K; Mailhos C; Dent C L; Latchman D S
Transactivation by the herpes simplex virus virion protein Vmw65 and viral permissivity in a neuronal cell line with reduced levels of the cellular transcription factor Oct-1.
Experimental cell research 1993;207(1):194-6.
1993: Horn D A; Latchman D S
A distal region of the CALC-1 gene is necessary for regulated alternative splicing.
FEBS letters 1993;324(2):123-6.
1993: Ring C J; Latchman D S
The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain.
Nucleic acids research 1993;21(12):2946.
1993: Willoughby J J; Ninkina N N; Beech M M; Latchman D S; Wood J N
Molecular cloning of a human neuronal nicotinic acetylcholine receptor beta 3-like subunit.
Neuroscience letters 1993;155(2):136-9.
1993: Howard M K; Burke L C; Mailhos C; Pizzey A; Gilbert C S; Lawson W D; Collins M K; Thomas N S; Latchman D S
Cell cycle arrest of proliferating neuronal cells by serum deprivation can result in either apoptosis or differentiation.
Journal of neurochemistry 1993;60(5):1783-91.
1993: Horn D A; Latchman D S
Alternative splicing of the mRNA encoding the alpha subunits of the G(o) GTP-binding protein during brain development and in neuronal cell lines.
Neuroscience letters 1993;155(1):57-60.
1993: Grimaldi K; Horn D A; Hudson L D; Terenghi G; Barton P; Polak J M; Latchman D S
Expression of the SmN splicing protein is developmentally regulated in the rodent brain but not in the rodent heart.
Developmental biology 1993;156(2):319-23.
1993: Gerrelli D; Grimaldi K; Horn D; Mahadeva U; Sharpe N; Latchman D S
The cardiac form of the tissue-specific SmN protein is identical to the brain and embryonic forms of the protein.
Journal of molecular and cellular cardiology 1993;25(3):321-9.
1993: Yellon D M; Latchman D S; Marber M S
Stress proteins--an endogenous route to myocardial protection: fact or fiction?
Cardiovascular research 1993;27(2):158-61.
1993: Morris P J; Dent C L; Ring C J; Latchman D S
The octamer binding site in the HPV16 regulatory region produces opposite effects on gene expression in cervical and non-cervical cells.
Nucleic acids research 1993;21(4):1019-23.
1992: Erkeller-Yüksel F M; Isenberg D A; Dhillon V B; Latchman D S; Lydyard P M
Surface expression of heat shock protein 90 by blood mononuclear cells from patients with systemic lupus erythematosus.
Journal of autoimmunity 1992;5(6):803-14.
1992: Wheatley S C; Suburo A M; Horn D A; Vucicevic V; Terenghi G; Polak J M; Latchman D S
Redistribution of secretory granule components precedes that of synaptic vesicle proteins during differentiation of a neuronal cell line in serum-free medium.
Neuroscience 1992;51(3):575-82.
1992: Lillycrop K A; Latchman D S
Alternative splicing of the Oct-2 transcription factor RNA is differentially regulated in neuronal cells and B cells and results in protein isoforms with opposite effects on the activity of octamer/TAATGARAT-containing promoters.
The Journal of biological chemistry 1992;267(35):24960-5.
1992: Horn D A; Suburo A; Terenghi G; Hudson L D; Polak J M; Latchman D S
Expression of the tissue specific splicing protein SmN in neuronal cell lines and in regions of the brain with different splicing capacities.
Brain research. Molecular brain research 1992;16(1-2):13-9.
1992: Lillycrop K A; Budrahan V S; Lakin N D; Terrenghi G; Wood J N; Polak J M; Latchman D S
A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells.
Nucleic acids research 1992;20(19):5093-6.
1992: Wood J N; Lillycrop K A; Dent C L; Ninkina N N; Beech M M; Willoughby J J; Winter J; Latchman D S
Regulation of expression of the neuronal POU protein Oct-2 by nerve growth factor.
The Journal of biological chemistry 1992;267(25):17787-91.
1992: Yellon D M; Pasini E; Cargnoni A; Marber M S; Latchman D S; Ferrari R
The protective role of heat stress in the ischaemic and reperfused rabbit myocardium.
Journal of molecular and cellular cardiology 1992;24(8):895-907.
1992: Latchman D S; Dent C L; Lillycrop K A; Wood J N
POU family transcription factors in sensory neurons.
Biochemical Society transactions 1992;20(3):627-31.
1992: Horn D A; Latchman D S
Neuronal expression of the tissue specific splicing protein SmN and its possible role in pre mRNA splicing.
Biochemical Society transactions 1992;20(3):266S.
1992: Jang K L; Latchman D S
The herpes simplex virus immediate-early protein ICP27 stimulates the transcription of cellular Alu repeated sequences by increasing the activity of transcription factor TFIIIC.
The Biochemical journal 1992;284 ( Pt 3)():667-73.
1992: Chapman C J; Harris J D; Hardwicke M A; Sandri-Goldin R M; Collins M K; Latchman D S
Promoter-independent activation of heterologous virus gene expression by the herpes simplex virus immediate-early protein ICP27.
Virology 1992;186(2):573-8.
1992: Yellon D M; Latchman D S
Stress proteins and myocardial protection.
Journal of molecular and cellular cardiology 1992;24(2):113-24.
1992: Wheatley S C; Dent C L; Wood J N; Latchman D S
Elevation of cyclic AMP levels in cell lines derived from latently infectable sensory neurons increases their permissivity for herpes virus infection by activating the viral immediate-early 1 gene promoter.
Brain research. Molecular brain research 1992;12(1-3):149-54.
1992: Grimaldi K; Gerrelli D; Sharpe N G; Lund T; Latchman D S
The intronless mouse gene for the tissue specific splicing protein SmN is a processed pseudogene containing a stop codon after thirty-one amino acids.
DNA sequence : the journal of DNA sequencing and mapping 1992;2(4):241-6.
1992: Jang K L; Collins M K; Latchman D S
The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC.
Journal of acquired immune deficiency syndromes 1992;5(11):1142-7.
1992: Suburo A M; Wheatley S C; Horn D A; Gibson S J; Jahn R; Fischer-Colbrie R; Wood J N; Latchman D S; Polak J M
Intracellular redistribution of neuropeptides and secretory proteins during differentiation of neuronal cell lines.
Neuroscience 1992;46(4):881-9.
1992: Dhillon V; Studd M; Isenberg O; Lehner T; Latchman D
Expression of the 90 kD heat shock protein in Behçet's syndrome.
Autoimmunity 1992;12(3):241-3.
1992: Twomey B; McCallum S; Dhillon V; Isenberg D; Latchman D
Transcription of the genes encoding the small heat shock protein ubiquitin is unchanged in patients with systemic lupus erythematosus.
Autoimmunity 1992;13(3):197-200.
1991: Gerrelli D; Sharpe N G; Latchman D S
Cloning and sequencing of a mouse embryonal carcinoma cell mRNA encoding the tissue specific RNA splicing protein SmN.
Nucleic acids research 1991;19(23):6642.
1991: Timmons P M; Brickell P M; Latchman D S; Rigby P W
Activation of endogenous retroviral transcription in SV40-transformed mouse cells.
Nucleic acids research 1991;19(25):7215-8.
1991: Dent C L; Lillycrop K A; Bybee A; Latchman D S; Thomas N S
Interferon-alpha treatment of Daudi cells down-regulates the octamer binding transcription/DNA replication factors Oct-1 and Oct-2.
The Journal of biological chemistry 1991;266(31):20888-92.
1991: Dhillon V; Latchman D; Isenberg D
Heat shock proteins and systemic lupus erythematosus.
Lupus 1991;1(1):3-8.
1991: Jang K L; Pulverer B; Woodgett J R; Latchman D S
Activation of the cellular transcription factor AP-1 in herpes simplex virus infected cells is dependent on the viral immediate-early protein ICPO.
Nucleic acids research 1991;19(18):4879-83.
1991: Lillycrop K A; Dent C L; Wheatley S C; Beech M N; Ninkina N N; Wood J N; Latchman D S
The octamer-binding protein Oct-2 represses HSV immediate-early genes in cell lines derived from latently infectable sensory neurons.
Neuron 1991;7(3):381-90.
1991: Dent C L; Lillycrop K A; Estridge J K; Thomas N S; Latchman D S
The B-cell and neuronal forms of the octamer-binding protein Oct-2 differ in DNA-binding specificity and functional activity.
Molecular and cellular biology 1991;11(8):3925-30.
1991: Lea I; Moore H D; Latchman D S
Differential expression of the mouse U1a and U1b SnRNA genes is not dependent on sequence differences in the octamer motif.
The Biochemical journal 1991;277 ( Pt 3)():719-22.
1991: Chapman C J; Harris J D; Collins M K; Latchman D S
A recombinant HIV provirus is synergistically activated by the HIV Tat protein and the HSV IE1 protein but not by the HSV IE3 protein.
AIDS (London, England) 1991;5(8):945-50.
1991: Dent C L; McIndoe G A; Latchman D S
The constitutively expressed octamer binding protein OTF-1 and a novel octamer binding protein expressed specifically in cervical cells bind to an octamer-related sequence in the human papillomavirus 16 enhancer.
Nucleic acids research 1991;19(16):4531-5.
1991: Bansal G S; Norton P M; Latchman D S
The 90-kDa heat shock protein protects mammalian cells from thermal stress but not from viral infection.
Experimental cell research 1991;195(2):303-6.
1991: Lillycrop K A; Latchman D S
Cloning and sequencing of the rat Oct-1 POU box.
Nucleic acids research 1991;19(13):3744.
1991: Dent C L; Latchman D S
The overlapping octamer/TAATGARAT motif is a high-affinity binding site for the cellular transcription factors Oct-1 and Oct-2.
The Biochemical journal 1991;277 ( Pt 2)():541-5.
1991: Wheatley S C; Dent C L; Wood J N; Latchman D S
A cellular factor binding to the TAATGARAT DNA sequence prevents the expression of the HSV immediate-early genes following infection of nonpermissive cell lines derived from dorsal root ganglion neurons.
Experimental cell research 1991;194(1):78-82.
1991: Latchman D S
The herpes simplex virus virion protein Vmw65 transcriptionally activates the gene encoding the U4 snRNA but not that encoding the U2 snRNA during lytic infection.
The Biochemical journal 1991;275 ( Pt 2)():369-72.
1990: Sharpe N G; Williams D G; Latchman D S
Regulated expression of the small nuclear ribonucleoprotein particle protein SmN in embryonic stem cell differentiation.
Molecular and cellular biology 1990;10(12):6817-20.
1990: Kemp L M; Gelman I H; Silverstein S J; Latchman D S
Regulation of herpes simplex virus immediate-early gene promoters in mouse neuroblastoma cells.
Neuroscience letters 1990;118(2):185-8.
1990: Estridge J K; Kemp L M; Latchman D S
The herpes simplex virus protein Vmw65 can trans-activate both viral and cellular promoters in neuronal cells.
The Biochemical journal 1990;271(1):273-6.
1990: Wheatley S C; Kemp L M; Wood J N; Latchman D S
Cell lines derived from dorsal root ganglion neurons are nonpermissive for HSV and express only the latency-associated transcript following infection.
Experimental cell research 1990;190(2):243-6.
1990: Latchman D S
Eukaryotic transcription factors.
The Biochemical journal 1990;270(2):281-9.
1990: Wood J N; Bevan S J; Coote P R; Dunn P M; Harmar A; Hogan P; Latchman D S; Morrison C; Rougon G; Theveniau M
Novel cell lines display properties of nociceptive sensory neurons.
Proceedings. Biological sciences / The Royal Society 1990;241(1302):187-94.
1990: Bansal G S; Latchman D S
Oestrogen enhances the responsiveness of the MMTV-LTR to glucocorticoid in ZR-75-1 human breast cancer cells.
Journal of steroid biochemistry 1990;36(5):399-405.
1990: Sharpe N G; Wall W; Latchman D S
Expression of the tissue specific RNA splicing protein SmN in HeLa cells.
Nucleic acids research 1990;18(11):3425-6.
1990: Kemp L M; Estridge J K; Brennan A; Katz D R; Latchman D S
Mononuclear phagocytes and HSV-1 infection: increased permissivity in differentiated U937 cells is mediated by post-transcriptional regulation of viral immediate-early gene expression.
Journal of leukocyte biology 1990;47(6):483-9.
1990: Dent C L; Estridge J K; Kemp L M; Latchman D S
Inhibition of histone H2B gene transcription and of cellular growth by a truncated viral trans-activator protein.
Molecular and cellular biology 1990;10(6):3258-61.
1990: Latchman D S
Current status review: molecular biology of herpes simplex virus latency.
Journal of experimental pathology (Oxford, England) 1990;71(1):133-41.
1990: Kemp L M; Dent C L; Latchman D S
Octamer motif mediates transcriptional repression of HSV immediate-early genes and octamer-containing cellular promoters in neuronal cells.
Neuron 1990;4(2):215-22.
1989: Jang K L; Latchman D S
HSV infection induces increased transcription of Alu repeated sequences by RNA polymerase III.
FEBS letters 1989;258(2):255-8.
1989: Latchman D S; Partidge J F; Estridge J K; Kemp L M
The different competitive abilities of viral TAATGARAT elements and cellular octamer motifs, mediate the induction of viral immediate-early genes and the repression of the histone H2B gene in herpes simplex virus infected cells.
Nucleic acids research 1989;17(21):8533-42.
1989: Sharpe N G; Isenberg D; Williams D G; Latchman D S
Elevation of the levels of SmB, B' and D proteins but not that of the La (SS-B) antigen during HSV infections.
Journal of autoimmunity 1989;2(5):701-8.
1989: Norton P M; Latchman D S
Levels of the 90kd heat shock protein and resistance to glucocorticoid-mediated cell killing in a range of human and murine lymphocyte cell lines.
Journal of steroid biochemistry 1989;33(2):149-54.
1989: Kemp L M; Latchman D S
Regulated transcription of herpes simplex virus immediate-early genes in neuroblastoma cells.
Virology 1989;171(2):607-10.
1989: Sharpe N G; Williams D G; Howarth D N; Coles B; Latchman D S
Isolation of cDNA clones encoding the human Sm B/B' auto-immune antigen and specifically reacting with human anti-Sm auto-immune sera.
FEBS letters 1989;250(2):585-90.
1989: Norton P M; Isenberg D A; Latchman D S
Elevated levels of the 90 kd heat shock protein in a proportion of SLE patients with active disease.
Journal of autoimmunity 1989;2(2):187-95.
1989: Sharpe N G; Williams D G; Norton P; Latchman D S
Expression of the SmB' splicing protein in rodent cells capable of following an alternative RNA splicing pathway.
FEBS letters 1989;243(2):132-6.
1989: Estridge J K; Kemp L M; La Thangue N B; Mann B S; Tyms A S; Latchman D S
The herpes simplex virus type 1 immediate-early protein ICP27 is obligately required for the accumulation of a cellular protein during viral infection.
Virology 1989;168(1):67-72.
1988: Kemp L M; Latchman D S
Differential regulation of octamer-containing cellular genes by the herpes simplex virus virion protein Vmw65 is mediated by sequence differences in the octamer element.
The EMBO journal 1988;7(13):4239-44.
1988: Davis J M; La Thangue N B; Taylor D L; Latchman D S; Anderson M; Tyms A S
Cellular polypeptides overexpressed after herpes simplex infection permit virus subtyping and may help diagnose cervical cancer.
Genitourinary medicine 1988;64(5):321-6.
1988: Kemp L M; Latchman D S
The herpes simplex virus type 1 immediate-early protein ICP4 specifically induces increased transcription of the human ubiquitin B gene without affecting the ubiquitin A and C genes.
Virology 1988;166(1):258-61.
1988: La Thangue N B; Latchman D S
A cellular protein related to heat-shock protein 90 accumulates during herpes simplex virus infection and is overexpressed in transformed cells.
Experimental cell research 1988;178(1):169-79.
1988: Latchman D S
A potential role for U1 RNA genes in gene duplication and conversion events.
FEBS letters 1988;236(1):5-8.
1988: Latchman D S
Effect of herpes simplex virus type 2 infection on mitochondrial gene expression.
The Journal of general virology 1988;69 ( Pt 6)():1405-10.
1988: Kemp L M; Latchman D S
Induction and repression of cellular gene transcription during herpes simplex virus infection are mediated by different viral immediate-early gene products.
European journal of biochemistry / FEBS 1988;174(2):443-9.
1987: Latchman D S; Estridge J K; Kemp L M
Transcriptional induction of the ubiquitin gene during herpes simplex virus infection is dependent upon the viral immediate-early protein ICP4.
Nucleic acids research 1987;15(18):7283-93.
1987: LaThangue N B; Latchman D S
Nuclear accumulation of a heat-shock 70-like protein during herpes simplex virus replication.
Bioscience reports 1987;7(6):475-83.
1987: Latchman D S; Chan W L; Leaver C E; Patel R; Oliver P; La Thangue N B
The human Mr 90,000 heat shock protein and the Escherichia coli Lon protein share an antigenic determinant.
Comparative biochemistry and physiology. B, Comparative biochemistry 1987;87(4):961-7.
1986: Kemp L M; Brickell P M; La Thangue N B; Latchman D S
Transcriptional induction of cellular gene expression during lytic infection with herpes simplex virus.
Bioscience reports 1986;6(11):945-51.
1986: Patel R; Chan W L; Kemp L M; La Thangue N B; Latchman D S
Isolation of cDNA clones derived from a cellular gene transcriptionally induced by herpes simplex virus.
Nucleic acids research 1986;14(14):5629-40.

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