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Edmond Lau

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Publications

TOP 3
Timothy S Carpenter; Edmond Y Lau; Felice C Lightstone
A role for loop F in modulating GABA binding affinity in the GABA(A) receptor.
Lucas Koziol; Edmond Y Lau; Felice C Lightstone; Joe H Satcher; Carlos A Valdez; Sergio E Wong; Sarah E Baker; William C Floyd; Roger D Aines
Toward a small molecule, biomimetic carbonic anhydrase model: theoretical and experimental investigations of a panel of zinc(II) aza-macrocyclic catalysts.
Wenwu Xiao; Yan Wang; Edmond Y Lau; Juntao Luo; Nianhuan Yao; Changying Shi; Leah Meza; Harry Tseng; Yoshiko Maeda; Pappanaicken Kumaresan; Ruiwu Liu; Felice C Lightstone; Yoshikazu Takada; Kit S Lam
The use of one-bead one-compound combinatorial library technology to discover high-affinity αvβ3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handle.

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All Publications

2012: Timothy S Carpenter; Edmond Y Lau; Felice C Lightstone
A role for loop F in modulating GABA binding affinity in the GABA(A) receptor.
Journal of molecular biology 2012;422(2):310-23.
2012: Lucas Koziol; Edmond Y Lau; Felice C Lightstone; Joe H Satcher; Carlos A Valdez; Sergio E Wong; Sarah E Baker; William C Floyd; Roger D Aines
Toward a small molecule, biomimetic carbonic anhydrase model: theoretical and experimental investigations of a panel of zinc(II) aza-macrocyclic catalysts.
Inorganic chemistry 2012;51(12):6803-12.
2010: Wenwu Xiao; Yan Wang; Edmond Y Lau; Juntao Luo; Nianhuan Yao; Changying Shi; Leah Meza; Harry Tseng; Yoshiko Maeda; Pappanaicken Kumaresan; Ruiwu Liu; Felice C Lightstone; Yoshikazu Takada; Kit S Lam
The use of one-bead one-compound combinatorial library technology to discover high-affinity αvβ3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handle.
Molecular cancer therapeutics 2010;9(10):2714-23.
2010: Justin Yamada; Joshua L Phillips; Samir Patel; Gabriel Goldfien; Alison Calestagne-Morelli; Hans Huang; Ryan Reza; Justin Acheson; Viswanathan V Krishnan; Shawn Newsam; Ajay Gopinathan; Edmond Y Lau; Michael E Colvin; Vladimir Uversky; Michael Rexach
A bimodal distribution of two distinct categories of intrinsically disordered structures with separate functions in FG nucleoporins.
Molecular & cellular proteomics : MCP 2010;9(10):2205-24.
2010: Richard D Carpenter; Arutselvan Natarajan; Edmond Y Lau; Mirela Andrei; Danielle M Solano; Felice C Lightstone; Sally J DeNardo; Kit S Lam; Mark J Kurth
Halogenated benzimidazole carboxamides target integrin alpha4beta1 on T-cell and B-cell lymphomas.
Cancer research 2010;70(13):5448-56.
2009: Richard D Carpenter; Mirela Andrei; Olulanu H Aina; Edmond Y Lau; Felice C Lightstone; Ruiwu Liu; Kit S Lam; Mark J Kurth
Selectively targeting T- and B-cell lymphomas: a benzothiazole antagonist of alpha4beta1 integrin.
Journal of medicinal chemistry 2009;52(1):14-9.
2008: Viswanathan V Krishnan; Edmond Y Lau; Justin Yamada; Daniel P Denning; Samir S Patel; Michael E Colvin; Michael F Rexach
Intramolecular cohesion of coils mediated by phenylalanine--glycine motifs in the natively unfolded domain of a nucleoporin.
PLoS computational biology 2008;4(8):e1000145.
2007: Richard D Carpenter; Mirela Andrei; Edmond Y Lau; Felice C Lightstone; Ruiwu Liu; Kit S Lam; Mark J Kurth
Highly potent, water soluble benzimidazole antagonist for activated alpha 4 beta 1 integrin.
Journal of medicinal chemistry 2007;50(23):5863-7.
2007: Edmond Y Lau; Viswanathan V Krishnan
Temperature dependence of protein-hydration hydrodynamics by molecular dynamics simulations.
Biophysical chemistry 2007;130(1-2):55-64.
2006: Edmond Y Lau; Felice C Lightstone; Michael E Colvin
Environmental effects on the structure of metal ion-DOTA complexes: an ab initio study of radiopharmaceutical metals.
Inorganic chemistry 2006;45(23):9225-32.
2006: Edmond Y Lau; James S Felton; Felice C Lightstone
Insights into the o-acetylation reaction of hydroxylated heterocyclic amines by human arylamine N-acetyltransferases: a computational study.
Chemical research in toxicology 2006;19(9):1182-90.
2006: Mark G Knize; Frederick T Hatch; MJ Tanga; Edmond Y Lau; Michael E Colvin
A QSAR for the mutagenic potencies of twelve 2-amino-trimethylimidazopyridine isomers: structural, quantum chemical, and hydropathic factors.
Environmental and molecular mutagenesis 2006;47(2):132-46.
2005: Todd A Sulchek; Raymond W Friddle; Kevin C Langry; Edmond Y Lau; Huguette Albrecht; Timothy V Ratto; Sally J DeNardo; Michael E Colvin; Aleksandr Noy
Dynamic force spectroscopy of parallel individual Mucin1-antibody bonds.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(46):16638-43.
2005: Viswanathan V Krishnan; Edmond Y Lau; Nelly M Tsvetkova; Robert E Feeney; William H Fink; Yin Yeh
Characterization of the restricted rotation of the dimethyl groups in chemically N-terminal 13C-labeled antifreeze glycoproteins: a temperature-dependent study in water to ice through the supercooled state.
The Journal of chemical physics 2005;123(4):044702.
2003: Laurence Brewer; Michele Corzett; Edmond Y Lau; Rod Balhorn
Dynamics of protamine 1 binding to single DNA molecules.
The Journal of biological chemistry 2003;278(43):42403-8.
2002: Zachary E R Newby; Edmond Y Lau; Thomas C Bruice
A theoretical examination of the factors controlling the catalytic efficiency of the DNA-(adenine-N6)-methyltransferase from Thermus aquaticus.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):7922-7.
2001: Edmond Y Lau; Thomas C Bruice
The active site dynamics of 4-chlorobenzoyl-CoA dehalogenase.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9527-32.
2001: Edmond Y Lau; Zachary E R Newby; Thomas C Bruice
A theoretical examination of the acid-catalyzed and noncatalyzed ring-opening reaction of an oxirane by nucleophilic addition of acetate. Implications to epoxide hydrolases.
Journal of the American Chemical Society 2001;123(14):3350-7.
2000: Edmond Y Lau; Kalju Kahn; P A Bash; Thomas C Bruice
The importance of reactant positioning in enzyme catalysis: a hybrid quantum mechanics/molecular mechanics study of a haloalkane dehalogenase.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):9937-42.
1999: Edmond Y Lau; Thomas C Bruice
Active site dynamics of the HhaI methyltransferase: insights from computer simulation.
Journal of molecular biology 1999;293(1):9-18.
1999: Edmond Y Lau; Thomas C Bruice
Consequences of breaking the Asp-His hydrogen bond of the catalytic triad: effects on the structure and dynamics of the serine esterase cutinase.
Biophysical journal 1999;77(1):85-98.
1997: Edmond Y Lau; John T Gerig
Effects of fluorine substitution on the structure and dynamics of complexes of dihydrofolate reductase (Escherichia coli).
Biophysical journal 1997;73(3):1579-92.