Lester Lau

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Chen Yi-Ju; Dominguez-Brauer Carmen; Wang Zebin; Asara John M; Costa Robert H; Tyner Angela L; Lau Lester F; Raychaudhuri Pradip
A conserved phosphorylation site within the forkhead domain of FoxM1B is required for its activation by cyclin-CDK1.
Park Hyun Jung; Carr Janai R; Wang Zebin; Nogueira Veronique; Hay Nissim; Tyner Angela L; Lau Lester F; Costa Robert H; Raychaudhuri Pradip
FoxM1, a critical regulator of oxidative stress during oncogenesis.
Franzen Carrie A; Chen Chih-Chiun; Todorovic Viktor; Juric Vladislava; Monzon Ricardo I; Lau Lester F
Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis.

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2009: Chen Yi-Ju; Dominguez-Brauer Carmen; Wang Zebin; Asara John M; Costa Robert H; Tyner Angela L; Lau Lester F; Raychaudhuri Pradip
A conserved phosphorylation site within the forkhead domain of FoxM1B is required for its activation by cyclin-CDK1.
The Journal of biological chemistry 2009;284(44):30695-707.
2009: Park Hyun Jung; Carr Janai R; Wang Zebin; Nogueira Veronique; Hay Nissim; Tyner Angela L; Lau Lester F; Costa Robert H; Raychaudhuri Pradip
FoxM1, a critical regulator of oxidative stress during oncogenesis.
The EMBO journal 2009;28(19):2908-18.
2009: Franzen Carrie A; Chen Chih-Chiun; Todorovic Viktor; Juric Vladislava; Monzon Ricardo I; Lau Lester F
Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis.
Molecular cancer research : MCR 2009;7(7):1045-55.
2009: Juric Vladislava; Chen Chih-Chiun; Lau Lester F
Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo.
Molecular and cellular biology 2009;29(12):3266-79.
2009: Chen Chih-Chiun; Lau Lester F
Functions and mechanisms of action of CCN matricellular proteins.
The international journal of biochemistry & cell biology 2009;41(4):771-83.
2008: Park Hyun Jung; Costa Robert H; Lau Lester F; Tyner Angela L; Raychaudhuri Pradip
Anaphase-promoting complex/cyclosome-CDH1-mediated proteolysis of the forkhead box M1 transcription factor is critical for regulated entry into S phase.
Molecular and cellular biology 2008;28(17):5162-71.
2008: Wang I-Ching; Chen Yi-Ju; Hughes Douglas E; Ackerson Timothy; Major Michael L; Kalinichenko Vladimir V; Costa Robert H; Raychaudhuri Pradip; Tyner Angela L; Lau Lester F
FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness.
The Journal of biological chemistry 2008;283(30):20770-8.
2008: Pestov Dimitri G; Lapik Yevgeniya R; Lau Lester F
Assays for ribosomal RNA processing and ribosome assembly.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2008;Chapter 22():Unit 22.11.
2008: Park H J; Wang Z; Costa R H; Tyner A; Lau L F; Raychaudhuri P
An N-terminal inhibitory domain modulates activity of FoxM1 during cell cycle.
Oncogene 2008;27(12):1696-704.
2008: Petrovic Vladimir; Costa Robert H; Lau Lester F; Raychaudhuri Pradip; Tyner Angela L
FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression.
The Journal of biological chemistry 2008;283(1):453-60.
2007: Lapik Yevgeniya R; Misra Julia M; Lau Lester F; Pestov Dimitri G
Restricting conformational flexibility of the switch II region creates a dominant-inhibitory phenotype in Obg GTPase Nog1.
Molecular and cellular biology 2007;27(21):7735-44.
2007: Chen Chih-Chiun; Young Jennifer L; Monzon Ricardo I; Chen Ningyu; Todorovic Viktor; Lau Lester F
Cytotoxicity of TNFalpha is regulated by integrin-mediated matrix signaling.
The EMBO journal 2007;26(5):1257-67.
2006: Raychaudhuri Pradip; Lau Lester F; Grayson Dennis; Kaplan Jack
Robert H. Costa: 1957-2006.
Hepatology (Baltimore, Md.) 2006;44(5):1364.
2006: Mo Fan-E; Lau Lester F
The matricellular protein CCN1 is essential for cardiac development.
Circulation research 2006;99(9):961-9.
2005: Todorovicç Viktor; Chen Chih-Chiun; Hay Nissim; Lau Lester F
The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts.
The Journal of cell biology 2005;171(3):559-68.
2005: Zhang Weiqing; Swanson Richard; Izaguirre Gonzalo; Xiong Yan; Lau Lester F; Olson Steven T
The heparin-binding site of antithrombin is crucial for antiangiogenic activity.
Blood 2005;106(5):1621-8.
2005: Lin Cristiane G; Chen Chih-Chiun; Leu Shr-Jeng; Grzeszkiewicz Tatiana M; Lau Lester F
Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing.
The Journal of biological chemistry 2005;280(9):8229-37.
2004: Leu Shr-Jeng; Chen Ningyu; Chen Chih-Chiun; Todorovic Viktor; Bai Tao; Juric Vladislava; Liu Ying; Yan Guoqiang; Lam Stephen C-T; Lau Lester F
Targeted mutagenesis of the angiogenic protein CCN1 (CYR61). Selective inactivation of integrin alpha6beta1-heparan sulfate proteoglycan coreceptor-mediated cellular functions.
The Journal of biological chemistry 2004;279(42):44177-87.
2004: Chen Ningyu; Leu Shr-Jeng; Todorovic Viktor; Lam Stephen C-T; Lau Lester F
Identification of a novel integrin alphavbeta3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells.
The Journal of biological chemistry 2004;279(42):44166-76.
2004: Lapik Yevgeniya R; Fernandes Croydon J; Lau Lester F; Pestov Dimitri G
Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis.
Molecular cell 2004;15(1):17-29.
2004: Zhang Weiqing; Chuang Yung-Jen; Swanson Richard; Li Juan; Seo Kyunga; Leung Lawrence; Lau Lester F; Olson Steven T
Antiangiogenic antithrombin down-regulates the expression of the proangiogenic heparan sulfate proteoglycan, perlecan, in endothelial cells.
Blood 2004;103(4):1185-91.
2003: Leu Shr-Jeng; Liu Ying; Chen Ningyu; Chen Chih-Chiun; Lam Stephen C-T; Lau Lester F
Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61).
The Journal of biological chemistry 2003;278(36):33801-8.
2003: Schober Joseph M; Lau Lester F; Ugarova Tatiana P; Lam Stephen C-T
Identification of a novel integrin alphaMbeta2 binding site in CCN1 (CYR61), a matricellular protein expressed in healing wounds and atherosclerotic lesions.
The Journal of biological chemistry 2003;278(28):25808-15.
2003: Latinkic B V; Mercurio S; Bennett B; Hirst E M A; Xu Q; Lau L F; Mohun T J; Smith J C
Xenopus Cyr61 regulates gastrulation movements and modulates Wnt signalling.
Development (Cambridge, England) 2003;130(11):2429-41.
2003: Lin Cristiane G; Leu Shr-Jeng; Chen Ningyu; Tebeau Christopher M; Lin Shao-Xia; Yeung Cho-Yau; Lau Lester F
CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family.
The Journal of biological chemistry 2003;278(26):24200-8.
2002: Mo Fan-E; Muntean Andrew G; Chen Chih-Chiun; Stolz Donna B; Watkins Simon C; Lau Lester F
CYR61 (CCN1) is essential for placental development and vascular integrity.
Molecular and cellular biology 2002;22(24):8709-20.
2002: Leu Shr-Jeng; Lam Stephen C-T; Lau Lester F
Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells.
The Journal of biological chemistry 2002;277(48):46248-55.
2002: Strezoska Zaklina; Pestov Dimitri G; Lau Lester F
Functional inactivation of the mouse nucleolar protein Bop1 inhibits multiple steps in pre-rRNA processing and blocks cell cycle progression.
The Journal of biological chemistry 2002;277(33):29617-25.
2002: Schober Joseph M; Chen Ningyu; Grzeszkiewicz Tatiana M; Jovanovic Igor; Emeson Eugene E; Ugarova Tatiana P; Ye Richard D; Lau Lester F; Lam Stephen C-T
Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions.
Blood 2002;99(12):4457-65.
2002: Grzeszkiewicz Tatiana M; Lindner Volkhard; Chen Ningyu; Lam Stephen C-T; Lau Lester F
The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans.
Endocrinology 2002;143(4):1441-50.
2001: Chen C C; Mo F E; Lau L F
The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts.
The Journal of biological chemistry 2001;276(50):47329-37.
2001: Pestov D G; Stockelman M G; Strezoska Z; Lau L F
ERB1, the yeast homolog of mammalian Bop1, is an essential gene required for maturation of the 25S and 5.8S ribosomal RNAs.
Nucleic acids research 2001;29(17):3621-30.
2001: Pestov D G; Strezoska Z; Lau L F
Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition.
Molecular and cellular biology 2001;21(13):4246-55.
2001: Latinkic B V; Mo F E; Greenspan J A; Copeland N G; Gilbert D J; Jenkins N A; Ross S R; Lau L F
Promoter function of the angiogenic inducer Cyr61gene in transgenic mice: tissue specificity, inducibility during wound healing, and role of the serum response element.
Endocrinology 2001;142(6):2549-57.
2001: Grzeszkiewicz T M; Kirschling D J; Chen N; Lau L F
CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain.
The Journal of biological chemistry 2001;276(24):21943-50.
2001: Chen C C; Chen N; Lau L F
The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts.
The Journal of biological chemistry 2001;276(13):10443-52.
2000: Strezoska Z; Pestov D G; Lau L F
Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and 5. 8S RRNA processing and 60S ribosome biogenesis.
Molecular and cellular biology 2000;20(15):5516-28.
2000: Chen N; Chen C C; Lau L F
Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans.
The Journal of biological chemistry 2000;275(32):24953-61.
1999: Jedsadayanmata A; Chen C C; Kireeva M L; Lau L F; Lam S C
Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3).
The Journal of biological chemistry 1999;274(34):24321-7.
1999: Lau L F; Lam S C
The CCN family of angiogenic regulators: the integrin connection.
Experimental cell research 1999;248(1):44-57.
1999: Babic A M; Chen C C; Lau L F
Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo.
Molecular and cellular biology 1999;19(4):2958-66.
1999: Pestov D G; Polonskaia M; Lau L F
Flow cytometric analysis of the cell cycle in transfected cells without cell fixation.
BioTechniques 1999;26(1):102-6.
1998: Pestov D G; Grzeszkiewicz T M; Lau L F
Isolation of growth suppressors from a cDNA expression library.
Oncogene 1998;17(24):3187-97.
1998: Babic A M; Kireeva M L; Kolesnikova T V; Lau L F
CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):6355-60.
1998: Kolesnikova T V; Lau L F
Human CYR61-mediated enhancement of bFGF-induced DNA synthesis in human umbilical vein endothelial cells.
Oncogene 1998;16(6):747-54.
1998: Kireeva M L; Lam S C; Lau L F
Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3.
The Journal of biological chemistry 1998;273(5):3090-6.
1997: Wong M; Kireeva M L; Kolesnikova T V; Lau L F
Cyr61, product of a growth factor-inducible immediate-early gene, regulates chondrogenesis in mouse limb bud mesenchymal cells.
Developmental biology 1997;192(2):492-508.
1997: Li Y; Lau L F
Adrenocorticotropic hormone regulates the activities of the orphan nuclear receptor Nur77 through modulation of phosphorylation.
Endocrinology 1997;138(10):4138-46.
1997: Shiyanov P; Hayes S; Chen N; Pestov D G; Lau L F; Raychaudhuri P
p27Kip1 induces an accumulation of the repressor complexes of E2F and inhibits expression of the E2F-regulated genes.
Molecular biology of the cell 1997;8(9):1815-27.
1997: Kireeva M L; Latinkic B V; Kolesnikova T V; Chen C C; Yang G P; Abler A S; Lau L F
Cyr61 and Fisp12 are both ECM-associated signaling molecules: activities, metabolism, and localization during development.
Experimental cell research 1997;233(1):63-77.
1996: Kireeva M L; MO F E; Yang G P; Lau L F
Cyr61, a product of a growth factor-inducible immediate-early gene, promotes cell proliferation, migration, and adhesion.
Molecular and cellular biology 1996;16(4):1326-34.
1996: Latinkic B V; Zeremski M; Lau L F
Elk-1 can recruit SRF to form a ternary complex upon the serum response element.
Nucleic acids research 1996;24(7):1345-51.
1994: Yoon J K; Lau L F
Involvement of JunD in transcriptional activation of the orphan receptor gene nur77 by nerve growth factor and membrane depolarization in PC12 cells.
Molecular and cellular biology 1994;14(12):7731-43.
1994: Pestov D G; Lau L F
Genetic selection of growth-inhibitory sequences in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12549-53.
1994: Latinkic B V; Lau L F
Transcriptional activation of the immediate early gene pip92 by serum growth factors requires both Ets and CArG-like elements.
The Journal of biological chemistry 1994;269(37):23163-70.
1994: Davis I J; Lau L F
Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and Nurr-1 in the adrenal glands.
Molecular and cellular biology 1994;14(5):3469-83.
1993: Duff J L; Marrero M B; Paxton W G; Charles C H; Lau L F; Bernstein K E; Berk B C
Angiotensin II induces 3CH134, a protein-tyrosine phosphatase, in vascular smooth muscle cells.
The Journal of biological chemistry 1993;268(35):26037-40.
1993: Sun H; Charles C H; Lau L F; Tonks N K
MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo.
Cell 1993;75(3):487-93.
1993: Williams G T; Lau L F
Activation of the inducible orphan receptor gene nur77 by serum growth factors: dissociation of immediate-early and delayed-early responses.
Molecular and cellular biology 1993;13(10):6124-36.
1993: Davis I J; Hazel T G; Chen R H; Blenis J; Lau L F
Functional domains and phosphorylation of the orphan receptor Nur77.
Molecular endocrinology (Baltimore, Md.) 1993;7(8):953-64.
1993: Charles C H; Sun H; Lau L F; Tonks N K
The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5292-6.
1993: Yoon J K; Lau L F
Transcriptional activation of the inducible nuclear receptor gene nur77 by nerve growth factor and membrane depolarization in PC12 cells.
The Journal of biological chemistry 1993;268(12):9148-55.
1993: Scearce L M; Laz T M; Hazel T G; Lau L F; Taub R
RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver.
The Journal of biological chemistry 1993;268(12):8855-61.
1993: Charles C H; Yoon J K; Simske J S; Lau L F
Genomic structure, cDNA sequence, and expression of gly96, a growth factor-inducible immediate-early gene encoding a short-lived glycosylated protein.
Oncogene 1993;8(3):797-801.
1992: O'Brien T P; Lau L F
Expression of the growth factor-inducible immediate early gene cyr61 correlates with chondrogenesis during mouse embryonic development.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1992;3(9):645-54.
1992: Charles C H; Abler A S; Lau L F
cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein.
Oncogene 1992;7(1):187-90.
1991: Yang G P; Lau L F
Cyr61, product of a growth factor-inducible immediate early gene, is associated with the extracellular matrix and the cell surface.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(7):351-7.
1991: Latinkic B V; O'Brien T P; Lau L F
Promoter function and structure of the growth factor-inducible immediate early gene cyr61.
Nucleic acids research 1991;19(12):3261-7.
1991: Davis I J; Hazel T G; Lau L F
Transcriptional activation by Nur77, a growth factor-inducible member of the steroid hormone receptor superfamily.
Molecular endocrinology (Baltimore, Md.) 1991;5(6):854-9.
1991: Hazel T G; Misra R; Davis I J; Greenberg M E; Lau L F
Nur77 is differentially modified in PC12 cells upon membrane depolarization and growth factor treatment.
Molecular and cellular biology 1991;11(6):3239-46.
1990: Charles C H; Simske J S; O'Brien T P; Lau L F
Pip92: a short-lived, growth factor-inducible protein in BALB/c 3T3 and PC12 cells.
Molecular and cellular biology 1990;10(12):6769-74.
1990: O'Brien T P; Yang G P; Sanders L; Lau L F
Expression of cyr61, a growth factor-inducible immediate-early gene.
Molecular and cellular biology 1990;10(7):3569-77.
1988: Hazel T G; Nathans D; Lau L F
A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8444-8.

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Lester Lau

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