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Douglas Lauffenburger

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
25
Wells, Alan
23
Wiley, Steven
14
Sorger, Peter
12
Griffith, Linda
10
Horwitz, Alan
10
Janes, Kevin
8
Hendriks, Bart
7
Kamm, Roger
7
Opresko, Lee
6
Haugh, JM
6
Albeck, John
5
Asthagiri, AR
5
Gaudet, Suzanne
5
Hautaniemi, Sampsa
5
Kumar, Neil

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Publications

TOP 3
Platt Manu O; Wilder Catera L; Wells Alan; Griffith Linda G; Lauffenburger Douglas A
Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells.
Platt Manu O; Roman Arian J; Wells Alan; Lauffenburger Douglas A; Griffith Linda G
Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells.
Kreeger Pamela K; Mandhana Roli; Alford Shannon K; Haigis Kevin M; Lauffenburger Douglas A
RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.

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All Publications

2009: Platt Manu O; Wilder Catera L; Wells Alan; Griffith Linda G; Lauffenburger Douglas A
Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells.
Stem cells (Dayton, Ohio) 2009;27(11):2804-14.
2009: Platt Manu O; Roman Arian J; Wells Alan; Lauffenburger Douglas A; Griffith Linda G
Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells.
Journal of cellular physiology 2009;221(2):306-17.
2009: Kreeger Pamela K; Mandhana Roli; Alford Shannon K; Haigis Kevin M; Lauffenburger Douglas A
RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.
Cancer research 2009;69(20):8191-9.
2009: Lee Jeong Hoon; Cosgrove Benjamin D; Lauffenburger Douglas A; Han Jongyoon
Microfluidic concentration-enhanced cellular kinase activity assay.
Journal of the American Chemical Society 2009;131(30):10340-1.
2009: Pritchard Justin R; Cosgrove Benjamin D; Hemann Michael T; Griffith Linda G; Wands Jack R; Lauffenburger Douglas A
Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death.
Molecular cancer therapeutics 2009;8(8):2183-92.
2009: Cosgrove Benjamin D; King Bracken M; Hasan Maya A; Alexopoulos Leonidas G; Farazi Paraskevi A; Hendriks Bart S; Griffith Linda G; Sorger Peter K; Tidor Bruce; Xu Jinghai J; Lauffenburger Douglas A
Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.
Toxicology and applied pharmacology 2009;237(3):317-30.
2009: Aldridge Bree B; Saez-Rodriguez Julio; Muhlich Jeremy L; Sorger Peter K; Lauffenburger Douglas A
Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling.
PLoS computational biology 2009;5(4):e1000340.
2009: Sachs Karen; Itani Solomon; Carlisle Jennifer; Nolan Garry P; Pe'er Dana; Lauffenburger Douglas A
Learning signaling network structures with sparsely distributed data.
Journal of computational biology : a journal of computational molecular cell biology 2009;16(2):201-12.
2009: Lazzara Matthew J; Lauffenburger Douglas A
Quantitative modeling perspectives on the ErbB system of cell regulatory processes.
Experimental cell research 2009;315(4):717-25.
2009: Wittmann Dominik M; Krumsiek Jan; Saez-Rodriguez Julio; Lauffenburger Douglas A; Klamt Steffen; Theis Fabian J
Transforming Boolean models to continuous models: methodology and application to T-cell receptor signaling.
BMC systems biology 2009;3():98.
2009: Chen William W; Schoeberl Birgit; Jasper Paul J; Niepel Mario; Nielsen Ulrik B; Lauffenburger Douglas A; Sorger Peter K
Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data.
Molecular systems biology 2009;5():239.
2008: Albeck John G; Burke John M; Spencer Sabrina L; Lauffenburger Douglas A; Sorger Peter K
Modeling a snap-action, variable-delay switch controlling extrinsic cell death.
PLoS biology 2008;6(12):2831-52.
2008: Kim Hyung-Do; Guo Tiffany W; Wu Angela P; Wells Alan; Gertler Frank B; Lauffenburger Douglas A
Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence.
Molecular biology of the cell 2008;19(10):4249-59.
2008: Harley Brendan A C; Kim Hyung-Do; Zaman Muhammad H; Yannas Ioannis V; Lauffenburger Douglas A; Gibson Lorna J
Microarchitecture of three-dimensional scaffolds influences cell migration behavior via junction interactions.
Biophysical journal 2008;95(8):4013-24.
2008: Cosgrove Benjamin D; Cheng Connie; Pritchard Justin R; Stolz Donna B; Lauffenburger Douglas A; Griffith Linda G
An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-alpha.
Hepatology (Baltimore, Md.) 2008;48(1):276-88.
2008: Kumar Neil; Afeyan Raffi; Kim Hyung-Do; Lauffenburger Douglas A
Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells.
Molecular pharmacology 2008;73(6):1668-78.
2008: Macdonald Alice; Horwitz A Rick; Lauffenburger Douglas A
Kinetic model for lamellipodal actin-integrin 'clutch' dynamics.
Cell adhesion & migration 2008;2(2):95-105.
2008: Palmer Megan J; Mahajan Vinay S; Trajman Lily C; Irvine Darrell J; Lauffenburger Douglas A; Chen Jianzhu
Interleukin-7 receptor signaling network: an integrated systems perspective.
Cellular & molecular immunology 2008;5(2):79-89.
2008: Albeck John G; Burke John M; Aldridge Bree B; Zhang Mingsheng; Lauffenburger Douglas A; Sorger Peter K
Quantitative analysis of pathways controlling extrinsic apoptosis in single cells.
Molecular cell 2008;30(1):11-25.
2008: Saez-Rodriguez Julio; Goldsipe Arthur; Muhlich Jeremy; Alexopoulos Leonidas G; Millard Bjorn; Lauffenburger Douglas A; Sorger Peter K
Flexible informatics for linking experimental data to mathematical models via DataRail.
Bioinformatics (Oxford, England) 2008;24(6):840-7.
2007: Zugates Gregory T; Tedford Nathan C; Zumbuehl Andreas; Jhunjhunwala Siddharth; Kang Christina S; Griffith Linda G; Lauffenburger Douglas A; Langer Robert; Anderson Daniel G
Gene delivery properties of end-modified poly(beta-amino ester)s.
Bioconjugate chemistry 2007;18(6):1887-96.
2007: Joslin Elizabeth J; Opresko Lee K; Wells Alan; Wiley H Steven; Lauffenburger Douglas A
EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation.
Journal of cell science 2007;120(Pt 20):3688-99.
2007: Miller-Jensen Kathryn; Janes Kevin A; Brugge Joan S; Lauffenburger Douglas A
Common effector processing mediates cell-specific responses to stimuli.
Nature 2007;448(7153):604-8.
2007: Wille Lucia; Kemp Melissa L; Sandy Peter; Lewis Christina L; Lauffenburger Douglas A
Epi-allelic Erk1 and Erk2 knockdown series for quantitative analysis of T cell Erk regulation and IL-2 production.
Molecular immunology 2007;44(12):3085-91.
2007: Kemp Melissa L; Wille Lucia; Lewis Christina L; Nicholson Lindsay B; Lauffenburger Douglas A
Quantitative network signal combinations downstream of TCR activation can predict IL-2 production response.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4984-92.
2007: Wolf-Yadlin Alejandro; Hautaniemi Sampsa; Lauffenburger Douglas A; White Forest M
Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):5860-5.
2007: Kumar Neil; Afeyan Raffi; Sheppard Sarah; Harms Brian; Lauffenburger Douglas A
Quantitative analysis of Akt phosphorylation and activity in response to EGF and insulin treatment.
Biochemical and biophysical research communications 2007;354(1):14-20.
2007: Kumar Neil; Wolf-Yadlin Alejandro; White Forest M; Lauffenburger Douglas A
Modeling HER2 effects on cell behavior from mass spectrometry phosphotyrosine data.
PLoS computational biology 2007;3(1):e4.
2007: Zaman Muhammad H; Matsudaira Paul; Lauffenburger Douglas A
Understanding effects of matrix protease and matrix organization on directional persistence and translational speed in three-dimensional cell migration.
Annals of biomedical engineering 2007;35(1):91-100.
2007: Kharait Sourabh; Hautaniemi Sampsa; Wu Shan; Iwabu Akihiro; Lauffenburger Douglas A; Wells Alan
Decision tree modeling predicts effects of inhibiting contractility signaling on cell motility.
BMC systems biology 2007;1():9.
2006: Hendriks B S; Griffiths G J; Benson R; Kenyon D; Lazzara M; Swinton J; Beck S; Hickinson M; Beusmans J M; Lauffenburger D; de Graaf D
Decreased internalisation of erbB1 mutants in lung cancer is linked with a mechanism conferring sensitivity to gefitinib.
Systems biology 2006;153(6):457-66.
2006: Aldridge B B; Haller G; Sorger P K; Lauffenburger D A
Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour.
Systems biology 2006;153(6):425-32.
2006: Aldridge Bree B; Burke John M; Lauffenburger Douglas A; Sorger Peter K
Physicochemical modelling of cell signalling pathways.
Nature cell biology 2006;8(11):1195-203.
2006: Albeck John G; MacBeath Gavin; White Forest M; Sorger Peter K; Lauffenburger Douglas A; Gaudet Suzanne
Collecting and organizing systematic sets of protein data.
Nature reviews. Molecular cell biology 2006;7(11):803-12.
2006: Lauffenburger Douglas A
Right on cue.
Nature chemical biology 2006;2(11):569-70.
2006: Miller-Jensen Kathryn; Janes Kevin A; Wong Yun-Ling; Griffith Linda G; Lauffenburger Douglas A
Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor necrosis-factor-induced apoptosis.
Journal of cell science 2006;119(Pt 18):3788-98.
2006: Kumar Neil; Hendriks Bart S; Janes Kevin A; de Graaf David; Lauffenburger Douglas A
Applying computational modeling to drug discovery and development.
Drug discovery today 2006;11(17-18):806-11.
2006: Hua Fei; Hautaniemi Sampsa; Yokoo Rayka; Lauffenburger Douglas A
Integrated mechanistic and data-driven modelling for multivariate analysis of signalling pathways.
Journal of the Royal Society, Interface / the Royal Society 2006;3(9):515-26.
2006: Kumar Neil; Zaman Muhammad H; Kim Hyung-Do; Lauffenburger Douglas A
A high-throughput migration assay reveals HER2-mediated cell migration arising from increased directional persistence.
Biophysical journal 2006;91(4):L32-4.
2006: Ideker Trey; Winslow L Raimond; Lauffenburger Douglas A
Bioengineering and systems biology.
Annals of biomedical engineering 2006;34(7):1226-33.
2006: Zaman Muhammad H; Trapani Linda M; Sieminski Alisha L; Mackellar Drew; Gong Haiyan; Kamm Roger D; Wells Alan; Lauffenburger Douglas A; Matsudaira Paul
Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):10889-94.
2006: Smith Kirsty D; Wells Alan; Lauffenburger Douglas A
Multiple signaling pathways mediate compaction of collagen matrices by EGF-stimulated fibroblasts.
Experimental cell research 2006;312(11):1970-82.
2006: Kharait Sourabh; Dhir Rajiv; Lauffenburger Douglas; Wells Alan
Protein kinase Cdelta signaling downstream of the EGF receptor mediates migration and invasiveness of prostate cancer cells.
Biochemical and biophysical research communications 2006;343(3):848-56.
2006: Janes Kevin A; Gaudet Suzanne; Albeck John G; Nielsen Ulrik B; Lauffenburger Douglas A; Sorger Peter K
The response of human epithelial cells to TNF involves an inducible autocrine cascade.
Cell 2006;124(6):1225-39.
2006: Janes Kevin A; Lauffenburger Douglas A
A biological approach to computational models of proteomic networks.
Current opinion in chemical biology 2006;10(1):73-80.
2006: Semino Carlos E; Kamm Roger D; Lauffenburger Douglas A
Autocrine EGF receptor activation mediates endothelial cell migration and vascular morphogenesis induced by VEGF under interstitial flow.
Experimental cell research 2006;312(3):289-98.
2006: Hendriks B S; Cook J; Burke J M; Beusmans J M; Lauffenburger D A; de Graaf D
Computational modelling of ErbB family phosphorylation dynamics in response to transforming growth factor alpha and heregulin indicates spatial compartmentation of phosphatase activity.
Systems biology 2006;153(1):22-33.
2006: Wolf-Yadlin Alejandro; Kumar Neil; Zhang Yi; Hautaniemi Sampsa; Zaman Muhammad; Kim Hyung-Do; Grantcharova Viara; Lauffenburger Douglas A; White Forest M
Effects of HER2 overexpression on cell signaling networks governing proliferation and migration.
Molecular systems biology 2006;2():54.
2006: Wells Alan; Harms Brian; Iwabu Akihiro; Koo Lily; Smith Kirsty; Griffith Linda; Lauffenburger Douglas A
Motility signaled from the EGF receptor and related systems.
Methods in molecular biology (Clifton, N.J.) 2006;327():159-77.
2005: Janes Kevin A; Albeck John G; Gaudet Suzanne; Sorger Peter K; Lauffenburger Douglas A; Yaffe Michael B
A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.
Science (New York, N.Y.) 2005;310(5754):1646-53.
2005: Kamei Daniel T; Lao Bert J; Ricci Margaret Speed; Deshpande Rohini; Xu Han; Tidor Bruce; Lauffenburger Douglas A
Quantitative methods for developing Fc mutants with extended half-lives.
Biotechnology and bioengineering 2005;92(6):748-60.
2005: Gaudet Suzanne; Janes Kevin A; Albeck John G; Pace Emily A; Lauffenburger Douglas A; Sorger Peter K
A compendium of signals and responses triggered by prodeath and prosurvival cytokines.
Molecular & cellular proteomics : MCP 2005;4(10):1569-90.
2005: Viswanathan Sowmya; Davey Ryan E; Cheng Donavan; Raghu Riyad C; Lauffenburger Douglas A; Zandstra Peter W
Clonal evolution of stem and differentiated cells can be predicted by integrating cell-intrinsic and -extrinsic parameters.
Biotechnology and applied biochemistry 2005;42(Pt 2):119-31.
2005: Zhang Yi; Wolf-Yadlin Alejandro; Ross Phillip L; Pappin Darryl J; Rush John; Lauffenburger Douglas A; White Forest M
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.
Molecular & cellular proteomics : MCP 2005;4(9):1240-50.
2005: Rao Balaji M; Driver Ian; Lauffenburger Douglas A; Wittrup K Dane
High-affinity CD25-binding IL-2 mutants potently stimulate persistent T cell growth.
Biochemistry 2005;44(31):10696-701.
2005: Zaman Muhammad H; Kamm Roger D; Matsudaira Paul; Lauffenburger Douglas A
Computational model for cell migration in three-dimensional matrices.
Biophysical journal 2005;89(2):1389-97.
2005: Yoshioka Jun; Prince Robin N; Huang Hayden; Perkins Scott B; Cruz Francisco U; MacGillivray Catherine; Lauffenburger Douglas A; Lee Richard T
Cardiomyocyte hypertrophy and degradation of connexin43 through spatially restricted autocrine/paracrine heparin-binding EGF.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(30):10622-7.
2005: Hua Fei; Cornejo Melanie G; Cardone Michael H; Stokes Cynthia L; Lauffenburger Douglas A
Effects of Bcl-2 levels on Fas signaling-induced caspase-3 activation: molecular genetic tests of computational model predictions.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):985-95.
2005: Dong Jianying; Opresko Lee K; Chrisler William; Orr Galya; Quesenberry Ryan D; Lauffenburger Douglas A; Wiley H Steven
The membrane-anchoring domain of epidermal growth factor receptor ligands dictates their ability to operate in juxtacrine mode.
Molecular biology of the cell 2005;16(6):2984-98.
2005: Hautaniemi Sampsa; Kharait Sourabh; Iwabu Akihiro; Wells Alan; Lauffenburger Douglas A
Modeling of signal-response cascades using decision tree analysis.
Bioinformatics (Oxford, England) 2005;21(9):2027-35.
2005: Sachs Karen; Perez Omar; Pe'er Dana; Lauffenburger Douglas A; Nolan Garry P
Causal protein-signaling networks derived from multiparameter single-cell data.
Science (New York, N.Y.) 2005;308(5721):523-9.
2005: Shults Melissa D; Janes Kevin A; Lauffenburger Douglas A; Imperiali Barbara
A multiplexed homogeneous fluorescence-based assay for protein kinase activity in cell lysates.
Nature methods 2005;2(4):277-83.
2005: Monine Michael I; Berezhkovskii Alexander M; Joslin Elizabeth J; Wiley H Steven; Lauffenburger Douglas A; Shvartsman Stanislav Y
Ligand accumulation in autocrine cell cultures.
Biophysical journal 2005;88(4):2384-90.
2005: Woolf Peter J; Prudhomme Wendy; Daheron Laurence; Daley George Q; Lauffenburger Douglas A
Bayesian analysis of signaling networks governing embryonic stem cell fate decisions.
Bioinformatics (Oxford, England) 2005;21(6):741-53.
2005: Harms Brian D; Bassi Gina M; Horwitz Alan Rick; Lauffenburger Douglas A
Directional persistence of EGF-induced cell migration is associated with stabilization of lamellipodial protrusions.
Biophysical journal 2005;88(2):1479-88.
2005: Rao Balaji M; Lauffenburger Douglas A; Wittrup K Dane
Integrating cell-level kinetic modeling into the design of engineered protein therapeutics.
Nature biotechnology 2005;23(2):191-4.
2005: Hendriks Bart S; Orr Gayla; Wells Alan; Wiley H Steven; Lauffenburger Douglas A
Parsing ERK activation reveals quantitatively equivalent contributions from epidermal growth factor receptor and HER2 in human mammary epithelial cells.
The Journal of biological chemistry 2005;280(7):6157-69.
2005: Wells Alan; Huttenlocher Anna; Lauffenburger Douglas A
Calpain proteases in cell adhesion and motility.
International review of cytology 2005;245():1-16.
2004: Said Maya R; Begley Thomas J; Oppenheim Alan V; Lauffenburger Douglas A; Samson Leona D
Global network analysis of phenotypic effects: protein networks and toxicity modulation in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(52):18006-11.
2004: Lazar Cheri S; Cresson Catherine M; Lauffenburger Douglas A; Gill Gordon N
The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface.
Molecular biology of the cell 2004;15(12):5470-80.
2004: Prudhomme Wendy A; Duggar Keith H; Lauffenburger Douglas A
Cell population dynamics model for deconvolution of murine embryonic stem cell self-renewal and differentiation responses to cytokines and extracellular matrix.
Biotechnology and bioengineering 2004;88(3):264-72.
2004: Maly Ivan V; Lee Richard T; Lauffenburger Douglas A
A model for mechanotransduction in cardiac muscle: effects of extracellular matrix deformation on autocrine signaling.
Annals of biomedical engineering 2004;32(10):1319-35.
2004: Rao Balaji M; Driver Ian; Lauffenburger Douglas A; Wittrup K Dane
Interleukin 2 (IL-2) variants engineered for increased IL-2 receptor alpha-subunit affinity exhibit increased potency arising from a cell surface ligand reservoir effect.
Molecular pharmacology 2004;66(4):864-9.
2004: Lu Hang; Koo Lily Y; Wang Wechung M; Lauffenburger Douglas A; Griffith Linda G; Jensen Klavs F
Microfluidic shear devices for quantitative analysis of cell adhesion.
Analytical chemistry 2004;76(18):5257-64.
2004: Tschumperlin Daniel J; Dai Guohao; Maly Ivan V; Kikuchi Tadashi; Laiho Lily H; McVittie Anna K; Haley Kathleen J; Lilly Craig M; So Peter T C; Lauffenburger Douglas A; Kamm Roger D; Drazen Jeffrey M
Mechanotransduction through growth-factor shedding into the extracellular space.
Nature 2004;429(6987):83-6.
2004: Iwabu Akihiro; Smith Kirsty; Allen Fred D; Lauffenburger Douglas A; Wells Alan
Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway.
The Journal of biological chemistry 2004;279(15):14551-60.
2004: Prudhomme Wendy; Daley George Q; Zandstra Peter; Lauffenburger Douglas A
Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):2900-5.
2004: Maly Ivan V; Wiley H Steven; Lauffenburger Douglas A
Self-organization of polarized cell signaling via autocrine circuits: computational model analysis.
Biophysical journal 2004;86(1 Pt 1):10-22.
2004: Lauffenburger Douglas A
Biological engineering and systems biology--new opportunities for engineers in the pharmaceutical industry.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2004;7():5456.
2004: Janes Kevin A; Kelly Jason R; Gaudet Suzanne; Albeck John G; Sorger Peter K; Lauffenburger Douglas A
Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data.
Journal of computational biology : a journal of computational molecular cell biology 2004;11(4):544-61.
2003: Rao Balaji M; Girvin Andrew T; Ciardelli Thomas; Lauffenburger Douglas A; Wittrup K Dane
Interleukin-2 mutants with enhanced alpha-receptor subunit binding affinity.
Protein engineering 2003;16(12):1081-7.
2003: Viswanathan Sowmya; Benatar Tania; Mileikovsky Maria; Lauffenburger Douglas A; Nagy Andras; Zandstra Peter W
Supplementation-dependent differences in the rates of embryonic stem cell self-renewal, differentiation, and apoptosis.
Biotechnology and bioengineering 2003;84(5):505-17.
2003: Hendriks Bart S; Wiley H Steven; Lauffenburger Douglas
HER2-mediated effects on EGFR endosomal sorting: analysis of biophysical mechanisms.
Biophysical journal 2003;85(4):2732-45.
2003: Mamoune Asmaa; Luo Jian-Hua; Lauffenburger Douglas A; Wells Alan
Calpain-2 as a target for limiting prostate cancer invasion.
Cancer research 2003;63(15):4632-40.
2003: Janes Kevin A; Albeck John G; Peng Lili X; Sorger Peter K; Lauffenburger Douglas A; Yaffe Michael B
A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis.
Molecular & cellular proteomics : MCP 2003;2(7):463-73.
2003: Ideker Trey; Lauffenburger Douglas
Building with a scaffold: emerging strategies for high- to low-level cellular modeling.
Trends in biotechnology 2003;21(6):255-62.
2003: Lauffenburger Douglas A; Wells Alan
Quantitative parsing of cell multi-tasking in wound repair and tissue morphogenesis.
Biophysical journal 2003;84(6):3499-500.
2003: Hendriks Bart S; Opresko Lee K; Wiley H Steven; Lauffenburger Douglas
Quantitative analysis of HER2-mediated effects on HER2 and epidermal growth factor receptor endocytosis: distribution of homo- and heterodimers depends on relative HER2 levels.
The Journal of biological chemistry 2003;278(26):23343-51.
2003: Sarkar Casim A; Lowenhaupt Ky; Wang Peggy J; Horan Thomas; Lauffenburger Douglas A
Parsing the effects of binding, signaling, and trafficking on the mitogenic potencies of granulocyte colony-stimulating factor analogues.
Biotechnology progress 2003;19(3):955-64.
2003: Ricci Margaret Speed; Sarkar Casim A; Fallon Eric M; Lauffenburger Douglas A; Brems David N
pH Dependence of structural stability of interleukin-2 and granulocyte colony-stimulating factor.
Protein science : a publication of the Protein Society 2003;12(5):1030-8.
2003: Hendriks Bart S; Opresko Lee K; Wiley H Steven; Lauffenburger Douglas
Coregulation of epidermal growth factor receptor/human epidermal growth factor receptor 2 (HER2) levels and locations: quantitative analysis of HER2 overexpression effects.
Cancer research 2003;63(5):1130-7.
2003: Sarkar Casim A; Lauffenburger Douglas A
Cell-level pharmacokinetic model of granulocyte colony-stimulating factor: implications for ligand lifetime and potency in vivo.
Molecular pharmacology 2003;63(1):147-58.
2003: Wiley H Steven; Shvartsman Stanislav Y; Lauffenburger Douglas A
Computational modeling of the EGF-receptor system: a paradigm for systems biology.
Trends in cell biology 2003;13(1):43-50.
2002: DeWitt Ann; Iida Tomoko; Lam Ho-Yan; Hill Virginia; Wiley H Steven; Lauffenburger Douglas A
Affinity regulates spatial range of EGF receptor autocrine ligand binding.
Developmental biology 2002;250(2):305-16.
2002: Sachs Karen; Gifford David; Jaakkola Tommi; Sorger Peter; Lauffenburger Douglas A
Bayesian network approach to cell signaling pathway modeling.
Science's STKE : signal transduction knowledge environment 2002;2002(148):pe38.
2002: Sarkar Casim A; Lowenhaupt Ky; Horan Thomas; Boone Thomas C; Tidor Bruce; Lauffenburger Douglas A
Rational cytokine design for increased lifetime and enhanced potency using pH-activated "histidine switching".
Nature biotechnology 2002;20(9):908-13.
2002: Shvartsman Stanislav Y; Muratov Cyrill B; Lauffenburger Douglas A
Modeling and computational analysis of EGF receptor-mediated cell communication in Drosophila oogenesis.
Development (Cambridge, England) 2002;129(11):2577-89.
2002: Koo Lily Y; Irvine Darrell J; Mayes Anne M; Lauffenburger Douglas A; Griffith Linda G
Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus.
Journal of cell science 2002;115(Pt 7):1423-33.
2002: Shvartsman S Y; Hagan M P; Yacoub A; Dent P; Wiley H S; Lauffenburger D A
Autocrine loops with positive feedback enable context-dependent cell signaling.
American journal of physiology. Cell physiology 2002;282(3):C545-59.
2002: Allen Fred D; Asnes Clara F; Chang Philip; Elson Elliot L; Lauffenburger Douglas A; Wells Alan
Epidermal growth factor induces acute matrix contraction and subsequent calpain-modulated relaxation.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2002;10(1):67-76.
2002: Glading Angela; Lauffenburger Douglas A; Wells Alan
Cutting to the chase: calpain proteases in cell motility.
Trends in cell biology 2002;12(1):46-54.
2002: Caplan Michael R; Schwartzfarb Elissa M; Zhang Shuguang; Kamm Roger D; Lauffenburger Douglas A
Control of self-assembling oligopeptide matrix formation through systematic variation of amino acid sequence.
Biomaterials 2002;23(1):219-27.
2002: Caplan Michael R; Schwartzfarb Elissa M; Zhang Shuguang; Kamm Roger D; Lauffenburger Douglas A
Effects of systematic variation of amino acid sequence on the mechanical properties of a self-assembling, oligopeptide biomaterial.
Journal of biomaterials science. Polymer edition 2002;13(3):225-36.
2002: Wells Alan; Kassis Jareer; Solava James; Turner Timothy; Lauffenburger Douglas A
Growth factor-induced cell motility in tumor invasion.
Acta oncologica (Stockholm, Sweden) 2002;41(2):124-30.
2001: Maheshwari G; Wiley H S; Lauffenburger D A
Autocrine epidermal growth factor signaling stimulates directionally persistent mammary epithelial cell migration.
The Journal of cell biology 2001;155(7):1123-8.
2001: Shvartsman S Y; Wiley H S; Deen W M; Lauffenburger D A
Spatial range of autocrine signaling: modeling and computational analysis.
Biophysical journal 2001;81(4):1854-67.
2001: Narang A; Subramanian K K; Lauffenburger D A
A mathematical model for chemoattractant gradient sensing based on receptor-regulated membrane phospholipid signaling dynamics.
Annals of biomedical engineering 2001;29(8):677-91.
2001: Orsello C E; Lauffenburger D A; Hammer D A
Molecular properties in cell adhesion: a physical and engineering perspective.
Trends in biotechnology 2001;19(8):310-6.
2001: DeWitt A E; Dong J Y; Wiley H S; Lauffenburger D A
Quantitative analysis of the EGF receptor autocrine system reveals cryptic regulation of cell response by ligand capture.
Journal of cell science 2001;114(Pt 12):2301-13.
2001: Glading A; Uberall F; Keyse S M; Lauffenburger D A; Wells A
Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling.
The Journal of biological chemistry 2001;276(26):23341-8.
2001: Kassis J; Lauffenburger D A; Turner T; Wells A
Tumor invasion as dysregulated cell motility.
Seminars in cancer biology 2001;11(2):105-17.
2001: Lauffenburger D A; Griffith L G
Who's got pull around here? Cell organization in development and tissue engineering.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4282-4.
2001: Asthagiri A R; Lauffenburger D A
A computational study of feedback effects on signal dynamics in a mitogen-activated protein kinase (MAPK) pathway model.
Biotechnology progress 2001;17(2):227-39.
2000: Asthagiri A R; Reinhart C A; Horwitz A F; Lauffenburger D A
The role of transient ERK2 signals in fibronectin- and insulin-mediated DNA synthesis.
Journal of cell science 2000;113 Pt 24():4499-510.
2000: Varga C M; Wickham T J; Lauffenburger D A
Receptor-mediated targeting of gene delivery vectors: insights from molecular mechanisms for improved vehicle design.
Biotechnology and bioengineering 2000;70(6):593-605.
2000: Haugh J M; Wells A; Lauffenburger D A
Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: mechanistic insights and predictions for molecular interventions.
Biotechnology and bioengineering 2000;70(2):225-38.
2000: Fallon E M; Lauffenburger D A
Computational model for effects of ligand/receptor binding properties on interleukin-2 trafficking dynamics and T cell proliferation response.
Biotechnology progress 2000;16(5):905-16.
2000: Zandstra P W; Le H V; Daley G Q; Griffith L G; Lauffenburger D A
Leukemia inhibitory factor (LIF) concentration modulates embryonic stem cell self-renewal and differentiation independently of proliferation.
Biotechnology and bioengineering 2000;69(6):607-17.
2000: Lauffenburger D A
Cell signaling pathways as control modules: complexity for simplicity?
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5031-3.
2000: Maheshwari G; Brown G; Lauffenburger D A; Wells A; Griffith L G
Cell adhesion and motility depend on nanoscale RGD clustering.
Journal of cell science 2000;113 ( Pt 10)():1677-86.
2000: Fallon E M; Liparoto S F; Lee K J; Ciardelli T L; Lauffenburger D A
Increased endosomal sorting of ligand to recycling enhances potency of an interleukin-2 analog.
The Journal of biological chemistry 2000;275(10):6790-7.
2000: Schaffer D V; Fidelman N A; Dan N; Lauffenburger D A
Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery.
Biotechnology and bioengineering 2000;67(5):598-606.
2000: Glading A; Chang P; Lauffenburger D A; Wells A
Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway.
The Journal of biological chemistry 2000;275(4):2390-8.
2000: Caplan M R; Moore P N; Zhang S; Kamm R D; Lauffenburger D A
Self-assembly of a beta-sheet protein governed by relief of electrostatic repulsion relative to van der Waals attraction.
Biomacromolecules 2000;1(4):627-31.
2000: Asthagiri A R; Lauffenburger D A
Bioengineering models of cell signaling.
Annual review of biomedical engineering 2000;2():31-53.
1999: Wells A; Ware M F; Allen F D; Lauffenburger D A
Shaping up for shipping out: PLCgamma signaling of morphology changes in EGF-stimulated fibroblast migration.
Cell motility and the cytoskeleton 1999;44(4):227-33.
1999: Haugh J M; Huang A C; Wiley H S; Wells A; Lauffenburger D A
Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts.
The Journal of biological chemistry 1999;274(48):34350-60.
1999: Asthagiri A R; Nelson C M; Horwitz A F; Lauffenburger D A
Quantitative relationship among integrin-ligand binding, adhesion, and signaling via focal adhesion kinase and extracellular signal-regulated kinase 2.
The Journal of biological chemistry 1999;274(38):27119-27.
1999: Zhang S; Yan L; Altman M; Lässle M; Nugent H; Frankel F; Lauffenburger D A; Whitesides G M; Rich A
Biological surface engineering: a simple system for cell pattern formation.
Biomaterials 1999;20(13):1213-20.
1999: Dong J; Opresko L K; Dempsey P J; Lauffenburger D A; Coffey R J; Wiley H S
Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6235-40.
1999: Maheshwari G; Wells A; Griffith L G; Lauffenburger D A
Biophysical integration of effects of epidermal growth factor and fibronectin on fibroblast migration.
Biophysical journal 1999;76(5):2814-23.
1999: Asthagiri A R; Horwitz A F; Lauffenburger D A
A rapid and sensitive quantitative kinase activity assay using a convenient 96-well format.
Analytical biochemistry 1999;269(2):342-7.
1999: Palecek S P; Horwitz A F; Lauffenburger D A
Kinetic model for integrin-mediated adhesion release during cell migration.
Annals of biomedical engineering 1999;27(2):219-35.
1999: Haugh J M; Schooler K; Wells A; Wiley H S; Lauffenburger D A
Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway.
The Journal of biological chemistry 1999;274(13):8958-65.
1998: Lauffenburger D A; Oehrtman G T; Walker L; Wiley H S
Real-time quantitative measurement of autocrine ligand binding indicates that autocrine loops are spatially localized.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15368-73.
1998: Maheshwari G; Lauffenburger D A
Deconstructing (and reconstructing) cell migration.
Microscopy research and technique 1998;43(5):358-68.
1998: Wiley H S; Woolf M F; Opresko L K; Burke P M; Will B; Morgan J R; Lauffenburger D A
Removal of the membrane-anchoring domain of epidermal growth factor leads to intracrine signaling and disruption of mammary epithelial cell organization.
The Journal of cell biology 1998;143(5):1317-28.
1998: Haugh J M; Lauffenburger D A
Analysis of receptor internalization as a mechanism for modulating signal transduction.
Journal of theoretical biology 1998;195(2):187-218.
1998: Lauffenburger D A; Fallon E M; Haugh J M
Scratching the (cell) surface: cytokine engineering for improved ligand/receptor trafficking dynamics.
Chemistry & biology 1998;5(10):R257-63.
1998: Schaffer D V; Lauffenburger D A
Optimization of cell surface binding enhances efficiency and specificity of molecular conjugate gene delivery.
The Journal of biological chemistry 1998;273(43):28004-9.
1998: Ware M F; Wells A; Lauffenburger D A
Epidermal growth factor alters fibroblast migration speed and directional persistence reciprocally and in a matrix-dependent manner.
Journal of cell science 1998;111 ( Pt 16)():2423-32.
1998: Reddy C C; Wells A; Lauffenburger D A
Comparative mitogenic potencies of EGF and TGF alpha and their dependence on receptor-limitation versus ligand-limitation.
Medical & biological engineering & computing 1998;36(4):499-507.
1998: Palecek S P; Huttenlocher A; Horwitz A F; Lauffenburger D A
Physical and biochemical regulation of integrin release during rear detachment of migrating cells.
Journal of cell science 1998;111 ( Pt 7)():929-40.
1998: Oehrtman G T; Wiley H S; Lauffenburger D A
Escape of autocrine ligands into extracellular medium: experimental test of theoretical model predictions.
Biotechnology and bioengineering 1998;57(5):571-82.
1998: Leon E J; Verma N; Zhang S; Lauffenburger D A; Kamm R D
Mechanical properties of a self-assembling oligopeptide matrix.
Journal of biomaterials science. Polymer edition 1998;9(3):297-312.
1997: Huttenlocher A; Palecek S P; Lu Q; Zhang W; Mellgren R L; Lauffenburger D A; Ginsberg M H; Horwitz A F
Regulation of cell migration by the calcium-dependent protease calpain.
The Journal of biological chemistry 1997;272(52):32719-22.
1997: Ware M F; Tice D A; Parsons S J; Lauffenburger D A
Overexpression of cellular Src in fibroblasts enhances endocytic internalization of epidermal growth factor receptor.
The Journal of biological chemistry 1997;272(48):30185-90.
1997: French A R; Lauffenburger D A
Controlling receptor/ligand trafficking: effects of cellular and molecular properties on endosomal sorting.
Annals of biomedical engineering 1997;25(4):690-707.
1997: Kuo S C; Hammer D A; Lauffenburger D A
Simulation of detachment of specifically bound particles from surfaces by shear flow.
Biophysical journal 1997;73(1):517-31.
1997: Haugh J M; Lauffenburger D A
Physical modulation of intracellular signaling processes by locational regulation.
Biophysical journal 1997;72(5):2014-31.
1997: Palecek S P; Loftus J C; Ginsberg M H; Lauffenburger D A; Horwitz A F
Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness.
Nature 1997;385(6616):537-40.
1996: Reddy C C; Niyogi S K; Wells A; Wiley H S; Lauffenburger D A
Engineering epidermal growth factor for enhanced mitogenic potency.
Nature biotechnology 1996;14(13):1696-9.
1996: Lauffenburger D A; Chu L; French A; Oehrtman G; Reddy C; Wells A; Niyogi S; Wiley H S
Engineering dynamics of growth factors and other therapeutic ligands.
Biotechnology and bioengineering 1996;52(1):61-80.
1996: Saterbak A; Lauffenburger D A
Adhesion mediated by bonds in series.
Biotechnology progress 1996;12(5):682-99.
1996: French A R; Lauffenburger D A
Intracellular receptor/ligand sorting based on endosomal retention components.
Biotechnology and bioengineering 1996;51(3):281-97.
1996: Palecek S P; Schmidt C E; Lauffenburger D A; Horwitz A F
Integrin dynamics on the tail region of migrating fibroblasts.
Journal of cell science 1996;109 ( Pt 5)():941-52.
1996: Reddy C C; Wells A; Lauffenburger D A
Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor alpha.
Journal of cellular physiology 1996;166(3):512-22.
1996: Chu L; Wiley H S; Lauffenburger D A
Endocytic Relay as a Potential Means for Enhancing Ligand Transport through Cellular Tissue Matrices: Analysis and Possible Implications for Drug Delivery.
Tissue engineering 1996;2(1):17-38.
1995: Schmidt C E; Dai J; Lauffenburger D A; Sheetz M P; Horwitz A F
Integrin-cytoskeletal interactions in neuronal growth cones.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(5 Pt 1):3400-7.
1995: Lauffenburger D A; Forsten K E; Will B; Wiley H S
Molecular/cell engineering approach to autocrine ligand control of cell function.
Annals of biomedical engineering 1995;23(3):208-15.
1995: French A R; Tadaki D K; Niyogi S K; Lauffenburger D A
Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction.
The Journal of biological chemistry 1995;270(9):4334-40.
1995: Will B H; Lauffenburger D A; Wiley H S
Studies on engineered autocrine systems: requirements for ligand release from cells producing an artificial growth factor.
Tissue engineering 1995;1(1):81-94.
1994: Forsten K E; Lauffenburger D A
The role of low-affinity interleukin-2 receptors in autocrine ligand binding: alternative mechanisms for enhanced binding effect.
Molecular immunology 1994;31(10):739-51.
1994: Reddy C C; Wells A; Lauffenburger D A
Proliferative response of fibroblasts expressing internalization-deficient epidermal growth factor (EGF) receptors is altered via differential EGF depletion effect.
Biotechnology progress 1994;10(4):377-84.
1994: Schmidt C E; Chen T; Lauffenburger D A
Simulation of integrin-cytoskeletal interactions in migrating fibroblasts.
Biophysical journal 1994;67(1):461-74.
1994: French A R; Sudlow G P; Wiley H S; Lauffenburger D A
Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions.
The Journal of biological chemistry 1994;269(22):15749-55.
1994: Herbst J J; Opresko L K; Walsh B J; Lauffenburger D A; Wiley H S
Regulation of postendocytic trafficking of the epidermal growth factor receptor through endosomal retention.
The Journal of biological chemistry 1994;269(17):12865-73.
1994: Wu P; Hoying J B; Williams S K; Kozikowski B A; Lauffenburger D A
Integrin-binding peptide in solution inhibits or enhances endothelial cell migration, predictably from cell adhesion.
Annals of biomedical engineering 1994;22(2):144-52.
1994: Forsten K E; Lauffenburger D A
Probability of autocrine ligand capture by cell-surface receptors: implications for ligand secretion measurements.
Journal of computational biology : a journal of computational molecular cell biology 1994;1(1):15-23.
1993: Kuo S C; Lauffenburger D A
Relationship between receptor/ligand binding affinity and adhesion strength.
Biophysical journal 1993;65(5):2191-200.
1993: Schmidt C E; Horwitz A F; Lauffenburger D A; Sheetz M P
Integrin-cytoskeletal interactions in migrating fibroblasts are dynamic, asymmetric, and regulated.
The Journal of cell biology 1993;123(4):977-91.
1993: DiMilla P A; Stone J A; Quinn J A; Albelda S M; Lauffenburger D A
Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength.
The Journal of cell biology 1993;122(3):729-37.
1993: Saterbak A; Kuo S C; Lauffenburger D A
Heterogeneity and probabilistic binding contributions to receptor-mediated cell detachment kinetics.
Biophysical journal 1993;65(1):243-52.
1993: Nunez M; Mayo K H; Starbuck C; Lauffenburger D
pH sensitivity of epidermal growth factor receptor complexes.
Journal of cellular biochemistry 1993;51(3):312-21.
1992: Forsten K E; Lauffenburger D A
Interrupting autocrine ligand-receptor binding: comparison between receptor blockers and ligand decoys.
Biophysical journal 1992;63(3):857-61.
1992: Ford R M; Lauffenburger D A
A simple expression for quantifying bacterial chemotaxis using capillary assay data: application to the analysis of enhanced chemotactic responses from growth-limited cultures.
Mathematical biosciences 1992;109(2):127-49.
1992: Starbuck C; Lauffenburger D A
Mathematical model for the effects of epidermal growth factor receptor trafficking dynamics on fibroblast proliferation responses.
Biotechnology progress 1992;8(2):132-43.
1992: Forsten K E; Lauffenburger D A
Autocrine ligand binding to cell receptors. Mathematical analysis of competition by solution "decoys".
Biophysical journal 1992;61(2):518-29.
1991: Cano M L; Lauffenburger D A; Zigmond S H
Kinetic analysis of F-actin depolymerization in polymorphonuclear leukocyte lysates indicates that chemoattractant stimulation increases actin filament number without altering the filament length distribution.
The Journal of cell biology 1991;115(3):677-87.
1991: Stokes C L; Lauffenburger D A
Analysis of the roles of microvessel endothelial cell random motility and chemotaxis in angiogenesis.
Journal of theoretical biology 1991;152(3):377-403.
1991: DiMilla P A; Barbee K; Lauffenburger D A
Mathematical model for the effects of adhesion and mechanics on cell migration speed.
Biophysical journal 1991;60(1):15-37.
1991: Stokes C L; Lauffenburger D A; Williams S K
Migration of individual microvessel endothelial cells: stochastic model and parameter measurement.
Journal of cell science 1991;99 ( Pt 2)():419-30.
1991: Wiley H S; Herbst J J; Walsh B J; Lauffenburger D A; Rosenfeld M G; Gill G N
The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor.
The Journal of biological chemistry 1991;266(17):11083-94.
1991: Ford R M; Lauffenburger D A
Analysis of chemotactic bacterial distributions in population migration assays using a mathematical model applicable to steep or shallow attractant gradients.
Bulletin of mathematical biology 1991;53(5):721-49.
1991: Charnick S B; Fisher E S; Lauffenburger D A
Computer simulations of cell-target encounter including biased cell motion toward targets: single and multiple cell-target simulations in two dimensions.
Bulletin of mathematical biology 1991;53(4):591-621.
1990: Stokes C L; Rupnick M A; Williams S K; Lauffenburger D A
Chemotaxis of human microvessel endothelial cells in response to acidic fibroblast growth factor.
Laboratory investigation; a journal of technical methods and pathology 1990;63(5):657-68.
1990: Cozens-Roberts C; Quinn J A; Lauffenburger D A
Receptor-mediated cell attachment and detachment kinetics. II. Experimental model studies with the radial-flow detachment assay.
Biophysical journal 1990;58(4):857-72.
1990: Cozens-Roberts C; Lauffenburger D A; Quinn J A
Receptor-mediated cell attachment and detachment kinetics. I. Probabilistic model and analysis.
Biophysical journal 1990;58(4):841-56.
1990: Stokes C L; Weisz P B; Williams S K; Lauffenburger D A
Inhibition of microvascular endothelial cell migration by beta-cyclodextrin tetradecasulfate and hydrocortisone.
Microvascular research 1990;40(2):279-84.
1990: Charnick S B; Lauffenburger D A
Mathematical analysis of cell-target encounter rates in three dimensions. Effect of chemotaxis.
Biophysical journal 1990;57(5):1009-23.
1990: Wattenbarger M R; Graves D J; Lauffenburger D A
Specific adhesion of glycophorin liposomes to a lectin surface in shear flow.
Biophysical journal 1990;57(4):765-77.
1990: Fisher E S; Lauffenburger D A
Analysis of the effects of immune cell motility and chemotaxis on target elimination dynamics.
Mathematical biosciences 1990;98(1):73-102.
1990: Farrell B E; Daniele R P; Lauffenburger D A
Quantitative relationships between single-cell and cell-population model parameters for chemosensory migration responses of alveolar macrophages to C5a.
Cell motility and the cytoskeleton 1990;16(4):279-93.
1989: Mayo K H; Nunez M; Burke C; Starbuck C; Lauffenburger D; Savage C R
Epidermal growth factor receptor binding is not a simple one-step process.
The Journal of biological chemistry 1989;264(30):17838-44.
1989: Glasgow J E; Farrell B E; Fisher E S; Lauffenburger D A; Daniele R P
The motile response of alveolar macrophages. An experimental study using single-cell and cell population approaches.
The American review of respiratory disease 1989;139(2):320-9.
1988: Rupnick M A; Stokes C L; Williams S K; Lauffenburger D A
Quantitative analysis of random motility of human microvessel endothelial cells using a linear under-agarose assay.
Laboratory investigation; a journal of technical methods and pathology 1988;59(3):363-72.
1988: Fisher E S; Lauffenburger D A; Daniele R P
The effect of alveolar macrophage chemotaxis on bacterial clearance from the lung surface.
The American review of respiratory disease 1988;137(5):1129-34.
1988: Linderman J J; Lauffenburger D A
Analysis of intracellular receptor/ligand sorting in endosomes.
Journal of theoretical biology 1988;132(2):203-45.
1988: Tranquillo R T; Lauffenburger D A; Zigmond S H
A stochastic model for leukocyte random motility and chemotaxis based on receptor binding fluctuations.
The Journal of cell biology 1988;106(2):303-9.
1988: Lauffenburger D A; Tranquillo R T; Zigmond S H
Concentration gradients of chemotactic factors in chemotaxis assays.
Methods in enzymology 1988;162():85-101.
1988: Tranquillo R T; Zigmond S H; Lauffenburger D A
Measurement of the chemotaxis coefficient for human neutrophils in the under-agarose migration assay.
Cell motility and the cytoskeleton 1988;11(1):1-15.
1987: Hammer D A; Lauffenburger D A
A dynamical model for receptor-mediated cell adhesion to surfaces.
Biophysical journal 1987;52(3):475-87.
1987: Lauffenburger D A; Rivero M; Kelly F; Ford R; DiRienzo J
Bacterial chemotaxis. Cell flux model, parameter measurement, population dynamics, and genetic manipulation.
Annals of the New York Academy of Sciences 1987;506():281-95.
1987: Lauffenburger D A; Linderman J; Berkowitz L
Analysis of mammalian cell growth factor receptor dynamics.
Annals of the New York Academy of Sciences 1987;506():147-62.

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