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Guy Laurent

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Sarah Bertoli; Nicole Dastugue; Eric Delabesse; Cécile Demur; Sophie Dobbelstein; Eliane Duchayne; Francoise Huguet; A Huynh; Guy Laurent; Valérie Lauwers-Cances; Véronique Mansat-De Mas; Michel Attal; Emilie Bérard; Audrey Sarry; Suzanne Tavitian; François Vergez; Christian Récher
Time from diagnosis to intensive chemotherapy initiation does not adversely impact the outcome of patients with acute myeloid leukemia.
Emilie-Fleur Gautier; Stéphane Giraudier; Elizabeth Hexner; Camille Laurent; Guy Laurent; Stéphane Manenti; N Bonnevialle; François Delhommeau; Cécile Demur; BERNARD DUCOMMUN; Caroline Marty; Muriel Picard; Christian Récher; Jean-Luc Villeval; Véronique Mansat-De Mas
The cell cycle regulator CDC25A is a target for JAK2V617F oncogene.
Christine Jean; Patrick Bogdanowicz; Nathalie Castex-Rizzi; Jean-Jacques Fournié; Marie-José Haure; Guy Laurent
UVA-activated synthesis of metalloproteinases 1, 3 and 9 is prevented by a broad-spectrum sunscreen.

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All Publications

2013: Sarah Bertoli; Nicole Dastugue; Eric Delabesse; Cécile Demur; Sophie Dobbelstein; Eliane Duchayne; Francoise Huguet; A Huynh; Guy Laurent; Valérie Lauwers-Cances; Véronique Mansat-De Mas; Michel Attal; Emilie Bérard; Audrey Sarry; Suzanne Tavitian; François Vergez; Christian Récher
Time from diagnosis to intensive chemotherapy initiation does not adversely impact the outcome of patients with acute myeloid leukemia.
Blood 2013;121(14):2618-26.
2012: Emilie-Fleur Gautier; Stéphane Giraudier; Elizabeth Hexner; Camille Laurent; Guy Laurent; Stéphane Manenti; N Bonnevialle; François Delhommeau; Cécile Demur; BERNARD DUCOMMUN; Caroline Marty; Muriel Picard; Christian Récher; Jean-Luc Villeval; Véronique Mansat-De Mas
The cell cycle regulator CDC25A is a target for JAK2V617F oncogene.
Blood 2012;119(5):1190-9.
2011: Christine Jean; Patrick Bogdanowicz; Nathalie Castex-Rizzi; Jean-Jacques Fournié; Marie-José Haure; Guy Laurent
UVA-activated synthesis of metalloproteinases 1, 3 and 9 is prevented by a broad-spectrum sunscreen.
Photodermatology, photoimmunology & photomedicine 2011;27(6):318-24.
2011: Christian Récher; Gilles SALLES; Catherine Thiéblemont; Hervé Tilly; Serge Bologna; Christophe Bonnet; André Bosly; Danielle Canioni; Olivier Casasnovas; Bertrand Coiffier; Bernadette Corront; Christophe Fermé; Christophe Fruchart; Jean Gabarre; Hervé Ghesquières; Corinne Haioun; Jean-Philippe jais; Maud Janvier; Fabrice Jardin; Guy Laurent; Thierry Jo Molina; Franck Morschhauser
Intensified chemotherapy with ACVBP plus rituximab versus standard CHOP plus rituximab for the treatment of diffuse large B-cell lymphoma (LNH03-2B): an open-label randomised phase 3 trial.
Lancet 2011;378(9806):1858-67.
2011: Camille Laurent; Guy Laurent; Sabina Müller; Anne Quillet-Mary; Sophie Allart; Talal Al-Saati; Pierre Brousset; Catherine Do; Sophie Duchez; Stefan Hohaus; Luigi Maria Larocca; Salvatore Valitutti
Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: a 3-D tissue-imaging study.
Blood 2011;118(20):5371-9.
2010: Laurent Alric; Delphine Bonnet; Guy Laurent; Nassim Kamar; Jacques Izopet
Chronic hepatitis E virus infection: successful virologic response to pegylated interferon-alpha therapy.
Annals of internal medicine 2010;153(2):135-6.
2010: Aude-Hélène Capietto; Samarh Keirallah; Emilie Gross; Nicolas Dauguet; Emilie Laprévotte; Christine Jean; Julie Gertner-Dardenne; Christine Bezombes; Anne Quillet-Mary; Mary Poupot; Loic Ysebaert; Guy Laurent; Jean-Jacques Fournié
Emerging concepts for the treatment of hematological malignancies with therapeutic monoclonal antibodies.
Current drug targets 2010;11(7):790-800.
2010: Samar Kheirallah; Pierre Caron; Emilie Gross; Anne Quillet-Mary; Justine Bertrand-Michel; Jean-Jacques Fournié; Guy Laurent; Christine Bezombes
Rituximab inhibits B-cell receptor signaling.
Blood 2010;115(5):985-94.
2009: Camille Laurent; Catherine Do; Randy D Gascoyne; Laurence Lamant; Loïc Ysebaert; Guy Laurent; Georges Delsol; Pierre Brousset
Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma: a rare clinicopathologic entity with poor prognosis.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(25):4211-6.
2009: Christine Jean; Amandine Blanc; Naïs Prade-Houdellier; Loïc Ysebaert; Hélène Hernandez-Pigeon; Talal Al Saati; Marie-José Haure; Addolorata Maria Luce Coluccia; Marie Charveron; Eric Delabesse; Guy Laurent
Epidermal growth factor receptor/beta-catenin/T-cell factor 4/matrix metalloproteinase 1: a new pathway for regulating keratinocyte invasiveness after UVA irradiation.
Cancer research 2009;69(8):3291-9.
2008: Ludivine Leseux; Guy Laurent; Camille Laurent; Maxime Rigo; Amandine Blanc; Daniel Olive; Christine Bezombes
PKC zeta mTOR pathway: a new target for rituximab therapy in follicular lymphoma.
Blood 2008;111(1):285-91.
2007: Naïs Prade-Houdellier; E Frébet; Cécile Demur; E-F Gautier; F Delhommeau; Annelise Bennaceur-Griscelli; C Gaudin; V Martinel; Guy Laurent; Véronique Mansat-De Mas; Odile Beyne-Rauzy
Human telomerase is regulated by erythropoietin and transforming growth factor-beta in human erythroid progenitor cells.
Leukemia 2007;21(11):2304-10.
2007: Christine Jean; Hélène Hernandez-Pigeon; Amandine Blanc; Marie Charveron; Guy Laurent
Epidermal growth factor receptor pathway mitigates UVA-induced G2/M arrest in keratinocyte cells.
The Journal of investigative dermatology 2007;127(10):2418-24.
2007: Alexandra Charruyer; Christine Jean; Audrey Colomba; Jean-Pierre Jaffrézou; Anne Quillet-Mary; Guy Laurent; Christine Bezombes
PKCzeta protects against UV-C-induced apoptosis by inhibiting acid sphingomyelinase-dependent ceramide production.
The Biochemical journal 2007;405(1):77-83.
2007: Fabien Guilloton; Christine Jean; Aurélie de Thonel; Guy Laurent; Anne Quillet-Mary
Granzyme B induction signalling pathway in acute myeloid leukemia cell lines stimulated by tumor necrosis factor alpha and Fas ligand.
Cellular signalling 2007;19(6):1132-40.
2007: Hélène Hernandez-Pigeon; Christine Jean; Alexandra Charruyer; Marie-José Haure; Caroline Baudouin; Marie Charveron; Anne Quillet-Mary; Guy Laurent
UVA induces granzyme B in human keratinocytes through MIF: implication in extracellular matrix remodeling.
The Journal of biological chemistry 2007;282(11):8157-64.
2007: Odile Beyne-Rauzy; Guy Laurent; Daniel Adoue
[Myelodysplastic syndromes in adults].
Presse médicale (Paris, France : 1983) 2007;36(3 Pt 2):481-91.
2006: Ludivine Leseux; Safouane HAMDI; Talal Al Saati; Florence Capilla; Christian Recher; Guy Laurent; Christine Bezombes
Syk-dependent mTOR activation in follicular lymphoma cells.
Blood 2006;108(13):4156-62.
2006: Loïc Ysebaert; Gaëtan Chicanne; Cécile Demur; Fabienne De Toni; Naïs Prade-Houdellier; Jean-Bernard Ruidavets; Véronique Mansat-De Mas; Françoise Rigal-Huguet; Guy Laurent; Bernard Payrastre; Stéphane Manenti; Claire Racaud-Sultan
Expression of beta-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis.
Leukemia 2006;20(7):1211-6.
2006: Hélène Hernandez-Pigeon; Christine Jean; Alexandra Charruyer; Marie-José Haure; Matthias Titeux; Laure Tonasso; Anne Quillet-Mary; Caroline Baudouin; Marie Charveron; Guy Laurent
Human keratinocytes acquire cellular cytotoxicity under UV-B irradiation. Implication of granzyme B and perforin.
The Journal of biological chemistry 2006;281(19):13525-32.
2006: Yvan Canitrot; Guy Laurent; Catherine Astarie-Dequeker; Christine Bordier; Christophe Cazaux; Jean-Sébastien Hoffmann
Enhanced expression and activity of DNA polymerase beta in chronic myelogenous leukemia.
Anticancer research 2006;26(1B):523-5.
2006: I Leroy; Guy Laurent; Anne Quillet-Mary
Mithramycin A activates Fas death pathway in leukemic cell lines.
Apoptosis : an international journal on programmed cell death 2006;11(1):113-9.
2005: F Guilloton; Aurélie de Thonel; Christine Jean; Cécile Demur; Véronique Mansat-De Mas; Guy Laurent; Anne Quillet-Mary
TNFalpha stimulates NKG2D-mediated lytic activity of acute myeloid leukemic cells.
Leukemia 2005;19(12):2206-14.
2005: Odile Beyne-Rauzy; Naïs Prade-Houdellier; Cécile Demur; Christian Recher; Jacques Ayel; Guy Laurent; Véronique Mansat-De Mas
Tumor necrosis factor-alpha inhibits hTERT gene expression in human myeloid normal and leukemic cells.
Blood 2005;106(9):3200-5.
2005: Ingrid Leroy; Aurélie de Thonel; Guy Laurent; Anne Quillet-Mary
Protein kinase C zeta associates with death inducing signaling complex and regulates Fas ligand-induced apoptosis.
Cellular signalling 2005;17(9):1149-57.
2005: Alexandra Charruyer; Solène Grazide; Christine Bezombes; Sabina Müller; Guy Laurent; Jean-Pierre Jaffrézou
UV-C light induces raft-associated acid sphingomyelinase and JNK activation and translocation independently on a nuclear signal.
The Journal of biological chemistry 2005;280(19):19196-204.
2005: Hélène Hernandez-Pigeon; Anne Quillet-Mary; Thierry Louat; Alexia Schambourg; Odile Humbert; Janick Selves; bernard salles; Guy Laurent; Dominique Lautier
hMutS alpha is protected from ubiquitin-proteasome-dependent degradation by atypical protein kinase C zeta phosphorylation.
Journal of molecular biology 2005;348(1):63-74.
2005: Christian Récher; Odile Beyne-Rauzy; Cécile Demur; Gaëtan Chicanne; Cedric Dos Santos; Véronique Mansat-De Mas; David Benzaquen; Guy Laurent; Françoise Huguet; Bernard Payrastre
Antileukemic activity of rapamycin in acute myeloid leukemia.
Blood 2005;105(6):2527-34.
2004: Dominique Delmas; Cédric Rébé; Olivier Micheau; Anne Athias; Philippe Gambert; Solène Grazide; Guy Laurent; Norbert Latruffe; Eric Solary
Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells.
Oncogene 2004;23(55):8979-86.
2004: Odile Beyne-Rauzy; Christian Recher; Nicole Dastugue; Cécile Demur; Géraldine Pottier; Guy Laurent; Laure Sabatier; Véronique Mansat-De Mas
Tumor necrosis factor alpha induces senescence and chromosomal instability in human leukemic cells.
Oncogene 2004;23(45):7507-16.
2004: Thierry Louat; Yvan Canitrot; Sandra Jousseaume; Caroline Baudouin; Pierre Canal; Guy Laurent; Dominique Lautier
Atypical protein kinase C stimulates nucleotide excision repair activity.
FEBS letters 2004;574(1-3):121-5.
2004: Isabelle Plo; F Bono; Christine Bezombes; A Alam; A Bruno; Guy Laurent
Nerve growth factor-induced protein kinase C stimulation contributes to TrkA-dependent inhibition of p75 neurotrophin receptor sphingolipid signaling.
Journal of neuroscience research 2004;77(4):465-74.
2004: Christine Bezombes; Solène Grazide; Céline Garret; Claire Fabre; Anne Quillet-Mary; Sabina Müller; Jean-Pierre Jaffrézou; Guy Laurent
Rituximab antiproliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains.
Blood 2004;104(4):1166-73.
2004: Sandrine Lacour; Arlette Hammann; Solène Grazide; Dominique Lagadic-Gossmann; Anne Athias; Odile Sergent; Guy Laurent; Philippe Gambert; Eric Solary; Marie-Thérèse Dimanche-Boitrel
Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells.
Cancer research 2004;64(10):3593-8.
2004: Jean-Pierre Jaffrezou; Guy Laurent
Ceramide : A New Target in Anticancer Research?
Bulletin du cancer 2004;91(5):E133-61.
2004: Pierre Delobel; David Brassat; Marie Danjoux; Jean-Albert Lotterie; Muriel Irsutti-Fjørtoft; Michel Clanet; Guy Laurent
Granulomatous angiitis of the central nervous system revealing Hodgkin's disease.
Journal of neurology 2004;251(5):611-2.
2004: Christian Recher; Loïc Ysebaert; Odile Beyne-Rauzy; Véronique Mansat-De Mas; Jean-Bernard Ruidavets; Pascal Cariven; Cécile Demur; Bernard Payrastre; Guy Laurent; Claire Racaud-Sultan
Expression of focal adhesion kinase in acute myeloid leukemia is associated with enhanced blast migration, increased cellularity, and poor prognosis.
Cancer research 2004;64(9):3191-7.
2004: Solène Grazide; Anne-Dominique Terrisse; Sandra Lerouge; Guy Laurent; Jean-Pierre Jaffrézou
Cytoprotective effect of glucosylceramide synthase inhibition against daunorubicin-induced apoptosis in human leukemic cell lines.
The Journal of biological chemistry 2004;279(18):18256-61.
2004: Hélène Hernandez-Pigeon; Guy Laurent; Odile Humbert; bernard salles; Dominique Lautier
Degadration of mismatch repair hMutSalpha heterodimer by the ubiquitin-proteasome pathway.
FEBS letters 2004;562(1-3):40-4.
2003: Odile Humbert; Ikbel Achour; Dominique Lautier; Guy Laurent; bernard salles
hMSH2 expression is driven by AP1-dependent regulation through phorbol-ester exposure.
Nucleic acids research 2003;31(19):5627-34.
2003: Yvan Canitrot; Rafal Falinski; Thierry Louat; Guy Laurent; Christophe Cazaux; Jean-Sébastien Hoffmann; Dominique Lautier; Tomasz Skorski
p210 BCR/ABL kinase regulates nucleotide excision repair (NER) and resistance to UV radiation.
Blood 2003;102(7):2632-7.
2003: Christine Bezombes; Guy Laurent; Jean-Pierre Jaffrézou
Implication of raft microdomains in drug induced apoptosis.
Current medicinal chemistry. Anti-cancer agents 2003;3(4):263-70.
2003: Véronique Mansat-De Mas; Françoise Rigal-Huguet; Georges Cassar; Emilienne Kuhlein; Guy Laurent; Nicole Dastugue
Chronic myeloid leukemia associated with B-cell chronic lymphocytic leukemia: evidence of two separate clones as shown by combined cell-sorting and fluorescence in situ hybridisation.
Leukemia & lymphoma 2003;44(5):867-9.
2003: Véronique Mansat-De Mas; Hélène Hernandez; Isabelle Plo; Christine Bezombes; Nicolas Maestre; Anne Quillet-Mary; Rodolphe Filomenko; Cécile Demur; Jean-Pierre Jaffrézou; Guy Laurent
Protein kinase Czeta mediated Raf-1/extracellular-regulated kinase activation by daunorubicin.
Blood 2003;101(4):1543-50.
2003: Nicolas Maestre; Christine Bezombes; Isabelle Plo; Thierry Levade; François Lavelle; Guy Laurent; Jean-Pierre Jaffrézou
Phosphatidylcholine-derived phosphatidic acid and diacylglycerol are involved in the signaling pathways activated by docetaxel.
Journal of experimental therapeutics & oncology 2003;3(1):36-46.
2002: Christine Bezombes; Aurélie de Thonel; Andriana Apostolou; Thierry Louat; Jean-Pierre Jaffrézou; Guy Laurent; Anne Quillet-Mary
Overexpression of protein kinase Czeta confers protection against antileukemic drugs by inhibiting the redox-dependent sphingomyelinase activation.
Molecular pharmacology 2002;62(6):1446-55.
2002: Anne-Dominique Terrisse; Christine Bezombes; Sandra Lerouge; Guy Laurent; Jean-Pierre Jaffrézou
Daunorubicin- and Ara-C-induced interphasic apoptosis of human type II leukemia cells is caspase-8-independent.
Biochimica et biophysica acta 2002;1584(2-3):99-103.
2002: Solène Grazide; Nicolas Maestre; Robert Jan Veldman; Christine Bezombes; Stéphane MADDENS; Thierry Levade; Guy Laurent; Jean-Pierre Jaffrézou
Ara-C- and daunorubicin-induced recruitment of Lyn in sphingomyelinase-enriched membrane rafts.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(12):1685-7.
2002: David Brassat; Christian Recher; Emmanuelle Waubant; Emmanuelle Le Page; Françoise Rigal-Huguet; Guy Laurent; Gilles Edan; Michel Clanet
Therapy-related acute myeloblastic leukemia after mitoxantrone treatment in a patient with MS.
Neurology 2002;59(6):954-5.
2002: Isabelle Plo; Hélène Hernandez; Glenda Kohlhagen; Dominique Lautier; Yves Pommier; Guy Laurent
Overexpression of the atypical protein kinase C zeta reduces topoisomerase II catalytic activity, cleavable complexes formation, and drug-induced cytotoxicity in monocytic U937 leukemia cells.
The Journal of biological chemistry 2002;277(35):31407-15.
2002: Stéphane MADDENS; Alexandra Charruyer; Isabelle Plo; Patrice Dubreuil; Stuart Berger; bernard salles; Guy Laurent; Jean-Pierre Jaffrézou
Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect.
Blood 2002;100(4):1294-301.
2002: Véronique Mansat-De Mas; Aurélie de Thonel; Vanessa Gaulin; Cécile Demur; Guy Laurent; Anne Quillet-Mary
Protein kinase C-zeta overexpression induces erythroid phenotype in the monocytic leukaemia cell line U937.
British journal of haematology 2002;118(2):646-53.
2002: Isabelle Plo; Gustav Lehne; Karen Johanne Beckstrøm; Nicolas Maestre; Ali Bettaïeb; Guy Laurent; Dominique Lautier
Influence of ceramide metabolism on P-glycoprotein function in immature acute myeloid leukemia KG1a cells.
Molecular pharmacology 2002;62(2):304-12.
2002: Odile Humbert; Thierry Hermine; Hélène Hernandez; Thomas Bouget; Janick Selves; Guy Laurent; bernard salles; Dominique Lautier
Implication of protein kinase C in the regulation of DNA mismatch repair protein expression and function.
The Journal of biological chemistry 2002;277(20):18061-8.
2002: Jean-Pierre Jaffrézou; Guy Laurent; Thierry Levade
Ceramide in regulation of apoptosis. Implication in multitoxicant resistance.
Sub-cellular biochemistry 2002;36():269-84.
2001: Aurélie de Thonel; Ali Bettaïeb; Christine Jean; Guy Laurent; Anne Quillet-Mary
Role of protein kinase C zeta isoform in Fas resistance of immature myeloid KG1a leukemic cells.
Blood 2001;98(13):3770-7.
2001: Isabelle Plo; Dominique Lautier; Nathalie Casteran; Patrice Dubreuil; Michel AROCK; Guy Laurent
Kit signaling and negative regulation of daunorubicin-induced apoptosis: role of phospholipase Cgamma.
Oncogene 2001;20(46):6752-63.
2001: Christine Bezombes; Isabelle Plo; Véronique Mansat-De Mas; Anne Quillet-Mary; Anne Nègre-Salvayre; Guy Laurent; Jean-Pierre Jaffrézou
Oxidative stress-induced activation of Lyn recruits sphingomyelinase and is requisite for its stimulation by Ara-C.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(9):1583-5.
2001: AP Bruno; Guy Laurent; Cécile Demur; J P Jaffrezou
Genotypical instability in undifferentiated cells: precursors for environmental adaptability?
Cell death and differentiation 2001;8(4):436-7.
2001: Nicolas Maestre; T R Tritton; Guy Laurent; Jean-Pierre Jaffrézou
Cell surface-directed interaction of anthracyclines leads to cytotoxicity and nuclear factor kappaB activation but not apoptosis signaling.
Cancer research 2001;61(6):2558-61.
2001: Christine Bezombes; Bruno Ségui; Olivier Cuvillier; AP Bruno; Emmanuelle Uro-Coste; Valérie Gouazé; Nathalie Andrieu-Abadie; Stéphane Carpentier; Guy Laurent; Robert Salvayre; Jean-Pierre Jaffrézou; Thierry Levade
Lysosomal sphingomyelinase is not solicited for apoptosis signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(2):297-9.
2001: Jean-Pierre Jaffrézou; AP Bruno; A Moisand; Thierry Levade; Guy Laurent
Activation of a nuclear sphingomyelinase in radiation-induced apoptosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):123-133.
2000: Isabelle Plo; Dominique Lautier; Thierry Levade; H Sekouri; Jean-Pierre Jaffrézou; Guy Laurent; Ali Bettaïeb
Phosphatidylcholine-specific phospholipase C and phospholipase D are respectively implicated in mitogen-activated protein kinase and nuclear factor kappaB activation in tumour-necrosis-factor-alpha-treated immature acute-myeloid-leukaemia cells.
The Biochemical journal 2000;351 Pt 2():459-67.
2000: A P Bruno; Dominique Lautier; A T d'Orgeix; Guy Laurent; Anne Quillet-Mary
Acute myeloblastic leukemic cells acquire cellular cytotoxicity under genotoxic stress: implication of granzyme B and perforin.
Blood 2000;96(5):1914-20.
2000: Bruno Ségui; Christine Bezombes; Emmanuelle Uro-Coste; Jeffrey A Medin; Nathalie Andrieu-Abadie; Nathalie Augé; A Brouchet; Guy Laurent; Robert Salvayre; Jean-Pierre Jaffrézou; Thierry Levade
Stress-induced apoptosis is not mediated by endolysosomal ceramide.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(1):36-47.
1999: Véronique Mansat-De Mas; Christine Bezombes; Anne Quillet-Mary; Ali Bettaïeb; A D D'orgeix; Guy Laurent; Jean-Pierre Jaffrézou
Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation and apoptosis induced by daunorubicin.
Molecular pharmacology 1999;56(5):867-74.
1999: Isabelle Plo; Ali Bettaïeb; Bernard Payrastre; Véronique Mansat-De Mas; C Bordier; A Rousse; A Kowalski-Chauvel; Guy Laurent; Dominique Lautier
The phosphoinositide 3-kinase/Akt pathway is activated by daunorubicin in human acute myeloid leukemia cell lines.
FEBS letters 1999;452(3):150-4.
1999: Yvan Canitrot; Dominique Lautier; Guy Laurent; Mathilde Fréchet; A Ahmed; A G Turhan; bernard salles; Christophe Cazaux; Jean-Sébastien Hoffmann
Mutator phenotype of BCR--ABL transfected Ba/F3 cell lines and its association with enhanced expression of DNA polymerase beta.
Oncogene 1999;18(17):2676-80.
1999: Ali Bettaïeb; Isabelle Plo; Véronique Mansat-De Mas; Anne Quillet-Mary; Thierry Levade; Guy Laurent; Jean-Pierre Jaffrézou
Daunorubicin- and mitoxantrone-triggered phosphatidylcholine hydrolysis: implication in drug-induced ceramide generation and apoptosis.
Molecular pharmacology 1999;55(1):118-25.
1998: Jean-Pierre Jaffrézou; Nicolas Maestre; V de Mas-Mansat; Christine Bezombes; Thierry Levade; Guy Laurent
Positive feedback control of neutral sphingomyelinase activity by ceramide.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(11):999-1006.
1998: Nathalie Augé; Isabelle Escargueil-Blanc; I Lajoie-Mazenc; I Suc; Nathalie Andrieu-Abadie; MT Pieraggi; M Chatelut; Jean-Claude Thiers; Jean-Pierre Jaffrézou; Guy Laurent; Thierry Levade; Anne Nègre-Salvayre; Robert Salvayre
Potential role for ceramide in mitogen-activated protein kinase activation and proliferation of vascular smooth muscle cells induced by oxidized low density lipoprotein.
The Journal of biological chemistry 1998;273(21):12893-900.
1998: Jean-Pierre Jaffrézou; Ali Bettaïeb; Thierry Levade; Guy Laurent
Antitumor agent-induced apoptosis in myeloid leukemia cells: a controlled suicide.
Leukemia & lymphoma 1998;29(5-6):453-63.
1998: AP Bruno; Guy Laurent; D Averbeck; Cécile Demur; J Bonnet; Ali Bettaïeb; Thierry Levade; Jean-Pierre Jaffrézou
Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation.
Cell death and differentiation 1998;5(2):172-82.
1998: Cécile Demur; C Muller; G Cassar; C Bousquet; M Laroche; Guy Laurent
Acute myeloid leukemia cells with low P-glycoprotein expression and high rhodamine 123 efflux capacity display high clonogenicity.
Leukemia 1998;12(2):192-9.
1998: Christine Bezombes; Nicolas Maestre; Guy Laurent; Thierry Levade; Ali Bettaïeb; Jean-Pierre Jaffrézou
Restoration of TNF-alpha-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(1):101-9.
1997: V Mansat; Guy Laurent; Thierry Levade; Ali Bettaïeb; Jean-Pierre Jaffrézou
The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin.
Cancer research 1997;57(23):5300-4.
1997: Anne Quillet-Mary; Jean-Pierre Jaffrézou; V Mansat; C Bordier; J Naval; Guy Laurent
Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis.
The Journal of biological chemistry 1997;272(34):21388-95.
1997: V Mansat; Ali Bettaïeb; Thierry Levade; Guy Laurent; Jean-Pierre Jaffrézou
Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(8):695-702.
1997: D Lautier; J D Bailly; Cécile Demur; J M Herbert; C Bousquet; Guy Laurent
Altered intracellular distribution of daunorubicin in immature acute myeloid leukemia cells.
International journal of cancer. Journal international du cancer 1997;71(2):292-9.
1996: A Bettaieb; M Record; M G Côme; A C Bras; H Chap; Guy Laurent; J P Jaffrézou
Opposite effects of tumor necrosis factor alpha on the sphingomyelin-ceramide pathway in two myeloid leukemia cell lines: role of transverse sphingomyelin distribution in the plasma membrane.
Blood 1996;88(4):1465-72.
1996: Jean-Pierre Jaffrézou; Thierry Levade; Ali Bettaïeb; N Andrieu; Christine Bezombes; Nicolas Maestre; S Vermeersch; A Rousse; Guy Laurent
Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis.
The EMBO journal 1996;15(10):2417-24.
1996: Anne Quillet-Mary; V Mansat; Eliane Duchayne; M G Come; M Allouche; J D Bailly; C Bordier; Guy Laurent
Daunorubicin-induced internucleosomal DNA fragmentation in acute myeloid cell lines.
Leukemia 1996;10(3):417-25.
1995: J D Bailly; P Pourquier; Jean-Pierre Jaffrézou; Eliane Duchayne; G Cassar; C Bordier; Guy Laurent
Effect of 5637-conditioned medium and recombinant cytokines on P-glycoprotein expression in a human GM-CSF-dependent leukemic myeloid cell line.
Leukemia 1995;9(10):1718-25.
1995: J D Bailly; C Muller; Jean-Pierre Jaffrézou; Cécile Demur; G Gassar; C Bordier; Guy Laurent
Lack of correlation between expression and function of P-glycoprotein in acute myeloid leukemia cell lines.
Leukemia 1995;9(5):799-807.
1995: Jean-Pierre Jaffrézou; G Chen; George E Durán; C Muller; C Bordier; Guy Laurent; Kevin Gang Chen; Thierry Levade
Inhibition of lysosomal acid sphingomyelinase by agents which reverse multidrug resistance.
Biochimica et biophysica acta 1995;1266(1):1-8.
1995: C Muller; F Goubin; E Ferrandis; I Cornil-Scharwtz; J D Bailly; C Bordier; Jean Bénard; Branimir I Sikic; Guy Laurent
Evidence for transcriptional control of human mdr1 gene expression by verapamil in multidrug-resistant leukemic cells.
Molecular pharmacology 1995;47(1):51-6.
1994: Michel Attal; F Bibeau; C Muller; Eliane Duchayne; Emilienne Kuhlein; G Cassar; Georges Delsol; Guy Laurent
Optimization of immunohistochemical detection of P-glycoprotein in chronic lymphoid disorders.
American journal of clinical pathology 1994;102(6):842-9.
1994: J Laredo; A Huynh; C Muller; Jean-Pierre Jaffrézou; J D Bailly; G Cassar; Guy Laurent; Cécile Demur
Effect of the protein kinase C inhibitor staurosporine on chemosensitivity to daunorubicin of normal and leukemic fresh myeloid cells.
Blood 1994;84(1):229-37.
1994: C Muller; J D Bailly; J P Jaffrezou; F Goubin; Guy Laurent
[Pharmacological control of P-glycoprotein expression].
Bulletin du cancer 1994;81(5):386-91.
1994: C Muller; J D Bailly; F Goubin; J Laredo; Jean-Pierre Jaffrézou; C Bordier; Guy Laurent
Verapamil decreases P-glycoprotein expression in multidrug-resistant human leukemic cell lines.
International journal of cancer. Journal international du cancer 1994;56(5):749-54.
1994: Jean-Pierre Jaffrézou; Branimir I Sikic; Guy Laurent
Cyclosporin A and cyclosporin SDZ PSC 833 enhance anti-CD5 ricin A-chain immunotoxins in human leukemic T cells.
Blood 1994;83(2):482-9.
1993: J Laredo; Cécile Demur; C Muller; S Saivin; G Cassar; C Bousquet; Nicole Dastugue; Jean-Pierre Jaffrézou; P Colombies; Guy Laurent
Effects of H-7 and staurosporine on proliferation and self-renewal of acute myeloid leukemia progenitors.
Leukemia 1993;7(6):813-20.
1993: Jean-Pierre Jaffrézou; Guy Laurent
The intriguing link between modulation of both multidrug resistance and ligand-toxin conjugate cytotoxicity.
FEBS letters 1993;323(3):191-7.
1992: Jean-Pierre Jaffrézou; Thierry Levade; P Chatelain; Guy Laurent
Modulation of subcellular distribution of doxorubicin in multidrug-resistant P388/ADR mouse leukemia cells by the chemosensitizer ((2-isopropyl-1-(4-[3-N-methyl-N-(3,4-dimethoxy-beta- phenethyl)amino]propyloxy)-benzenesulfonyl))indolizine.
Cancer research 1992;52(23):6440-6.
1992: M Chiron; Cécile Demur; V Pierson; J P Jaffrezou; C Muller; S Saivin; C Bordier; C Bousquet; Nicole Dastugue; Guy Laurent
Sensitivity of fresh acute myeloid leukemia cells to etoposide: relationship with cell growth characteristics and DNA single-strand breaks.
Blood 1992;80(5):1307-15.
1992: Jean-Pierre Jaffrézou; Thierry Levade; O Thurneyssen; M Chiron; C Bordier; Michel Attal; P Chatelain; Guy Laurent
In vitro and in vivo enhancement of ricin-A chain immunotoxin activity by novel indolizine calcium channel blockers: delayed intracellular degradation linked to lipidosis induction.
Cancer research 1992;52(5):1352-9.
1992: Cécile Demur; M Chiron; S Saivin; Michel Attal; Nicole Dastugue; C Bousquet; J L Galinier; P Colombies; Guy Laurent
Effect of melphalan against self-renewal capacity of leukemic progenitors in acute myeloblastic leukemia.
Leukemia 1992;6(3):204-8.
1991: Jean-Pierre Jaffrézou; J M Herbert; Thierry Levade; M N Gau; P Chatelain; Guy Laurent
Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffinity labeling of P-glycoprotein.
The Journal of biological chemistry 1991;266(29):19858-64.
1991: Eliane Duchayne; Georges Delsol; Emilienne Kuhlein; B Klein; X G Zhang; Michel Attal; G Cassard; Guy Laurent
Hairy cell transformation of a B-cell chronic lymphocytic leukemia: a morphological, cytochemical, phenotypic and molecular study.
Leukemia 1991;5(2):150-5.
1990: M Chiron; J P Jaffrezou; P Carayon; C Bordier; Francis Roubinet; C Xavier; M Brandely; Guy Laurent
Induction and increase of HLA-DR antigen expression by immune interferon on ML-3 cell line enhances the anti-HLA-DR immunotoxin activity.
Clinical and experimental immunology 1990;82(2):214-20.
1990: M Chiron; J M Darbon; Francis Roubinet; G Cassar; J P Jaffrezou; C Bordier; Guy Laurent
Quantitative analysis of CD5 antigen modulation by 12-O-tetradecanoylphorbol-13-acetate in T-lymphoblastic leukemia cells: individual response patterns and their relationships with both maturation and protein kinase C content.
Cellular immunology 1990;130(2):339-51.
1990: Jean-Pierre Jaffrézou; Thierry Levade; Emilienne Kuhlein; O Thurneyssen; M Chiron; H Grandjean; D Carrière; Guy Laurent
Enhancement of ricin A chain immunotoxin activity by perhexiline on established and fresh leukemic cells.
Cancer research 1990;50(17):5558-66.
1989: M Chiron; Jean-Marie Derocq; Emilienne Kuhlein; Francis Roubinet; Cécile Demur; H Grandjean; F Huguet; J P Jaffrezou; F Jansen; Guy Laurent
Sensitivity of fresh leukemic cells to T101 ricin A-chain immunotoxin: a comparative study between Fab fragment and whole Ig conjugates.
Leukemia research 1989;13(6):491-9.
1989: Cécile Demur; Jean-Marie Derocq; P Poncelet; M Chiron; Francis Roubinet; J P Jaffrezou; C Bordier; Guy Laurent
Effects of an anti HLA-DR immunotoxin on leukaemia cells and hematopoietic progenitors.
Leukemia research 1989;13(12):1047-54.
1986: Guy Laurent; J Pris; J P Farcet; Pierre Carayon; H Blythman; Pierre Casellas; P Poncelet; F K Jansen
Effects of therapy with T101 ricin A-chain immunotoxin in two leukemia patients.
Blood 1986;67(6):1680-7.
1986: Guy Laurent; Emilienne Kuhlein; Pierre Casellas; X Canat; Pierre Carayon; P Poncelet; S Correll; F Rigal; F K Jansen
Determination of sensitivity of fresh leukemia cells to immunotoxins.
Cancer research 1986;46(5):2289-94.
1985: Pierre Casellas; X Canat; A A Fauser; O Gros; Guy Laurent; P Poncelet; F K Jansen
Optimal elimination of leukemic T cells from human bone marrow with T101-ricin A-chain immunotoxin.
Blood 1985;65(2):289-97.
1982: Emilienne Kuhlein; Guy Laurent; F Rigal; Georges Delsol; Jacques Pris; J Ducos
Spontaneous mouse erythrocyte-rosette formation in chronic lymphocytic leukaemia.
Clinical and experimental immunology 1982;47(2):389-95.
1981: Georges Delsol; Guy Laurent; Emilienne Kuhlein; J Familiades; F Rigal; Jacques Pris
Richter's syndrome. Evidence for the clonal origin of the two proliferations.
American journal of clinical pathology 1981;76(3):308-15.
1981: Guy Laurent; M F Gourdin; G Flandrin; Emilienne Kuhlein; Jacques Pris; F Reyes
Acute blast crisis in a patient with chronic lymphocytic leukemia. Immunoperoxidase study.
Acta haematologica 1981;65(1):60-6.