Ian Adcock

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Disorders

Chemicals & Drugs

Anatomy

Lung
Bronchi

Physiology

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Publications

TOP 3
Di Stefano A; Caramori G; Gnemmi I; Contoli M; Bristot L; Capelli A; Ricciardolo F L M; Magno F; D'Anna S Ennio; Zanini A; Carbone M; Sabatini F; Usai C; Brun P; Chung K F; Barnes P J; Papi A; Adcock I M; Balbi B
Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD.
Caramori Gaetano; Casolari Paolo; Di Gregorio Carmela; Saetta Marina; Baraldo Simonetta; Boschetto Piera; Ito Kazuhiro; Fabbri Leonardo M; Barnes Peter J; Adcock Ian M; Cavallesco Giorgio; Chung Kian F; Papi Alberto
MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients.
Chung Kian Fan; Caramori Gaetano; Adcock Ian M
Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future.

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All Publications

2009: Di Stefano A; Caramori G; Gnemmi I; Contoli M; Bristot L; Capelli A; Ricciardolo F L M; Magno F; D'Anna S Ennio; Zanini A; Carbone M; Sabatini F; Usai C; Brun P; Chung K F; Barnes P J; Papi A; Adcock I M; Balbi B
Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD.
Thorax 2009;64(11):968-75.
2009: Caramori Gaetano; Casolari Paolo; Di Gregorio Carmela; Saetta Marina; Baraldo Simonetta; Boschetto Piera; Ito Kazuhiro; Fabbri Leonardo M; Barnes Peter J; Adcock Ian M; Cavallesco Giorgio; Chung Kian F; Papi Alberto
MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients.
Histopathology 2009;55(3):321-31.
2009: Chung Kian Fan; Caramori Gaetano; Adcock Ian M
Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future.
European journal of clinical pharmacology 2009;65(9):853-71.
2009: Adcock Ian M; Chou Pai-Chien; Durham Andrew; Ford Paul
Overcoming steroid unresponsiveness in airways disease.
Biochemical Society transactions 2009;37(Pt 4):824-9.
2009: Di Stefano A; Caramori G; Gnemmi I; Contoli M; Vicari C; Capelli A; Magno F; D'Anna S E; Zanini A; Brun P; Casolari P; Chung K F; Barnes P J; Papi A; Adcock I; Balbi B
T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients.
Clinical and experimental immunology 2009;157(2):316-24.
2009: Osoata Grace O; Yamamura Satoshi; Ito Misako; Vuppusetty Chaitanya; Adcock Ian M; Barnes Peter J; Ito Kazuhiro
Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2.
Biochemical and biophysical research communications 2009;384(3):366-71.
2009: Papi Alberto; Caramori Gaetano; Adcock Ian M; Barnes Peter J
Rescue treatment in asthma. More than as-needed bronchodilation.
Chest 2009;135(6):1628-33.
2009: Barnes Peter J; Adcock Ian M
Glucocorticoid resistance in inflammatory diseases.
Lancet 2009;373(9678):1905-17.
2009: Maneechotesuwan Kittipong; Yao Xin; Ito Kazuhiro; Jazrawi Elen; Usmani Omar S; Adcock Ian M; Barnes Peter J
Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease.
PLoS medicine 2009;6(5):e1000076.
2009: Marwick John A; Caramori Gaetano; Stevenson Christopher S; Casolari Paolo; Jazrawi Elen; Barnes Peter J; Ito Kazuhiro; Adcock Ian M; Kirkham Paul A; Papi Alberto
Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice.
American journal of respiratory and critical care medicine 2009;179(7):542-8.
2009: Caramori Gaetano; Adcock Ian M; Papi Alberto
Clinical definition of COPD exacerbations and classification of their severity.
Southern medical journal 2009;102(3):277-82.
2009: Williams Alison S; Eynott Paul R; Leung Sum-Yee; Nath Puneeta; Jupp Ray; De Sanctis George T; Resnick Robert; Adcock Ian M; Chung Kian Fan
Role of cathepsin S in ozone-induced airway hyperresponsiveness and inflammation.
Pulmonary pharmacology & therapeutics 2009;22(1):27-32.
2009: Williams Andrew E; Larner-Svensson Hanna; Perry Mark M; Campbell Gaynor A; Herrick Sarah E; Adcock Ian M; Erjefalt Jonas S; Chung Kian Fan; Lindsay Mark A
MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy.
PloS one 2009;4(6):e5889.
2008: Williams Alison S; Issa Razao; Durham Andrew; Leung Sum-Yee; Kapoun Ann; Medicherla Satyanarayana; Higgins Linda S; Adcock Ian M; Chung Kian Fan
Role of p38 mitogen-activated protein kinase in ozone-induced airway hyperresponsiveness and inflammation.
European journal of pharmacology 2008;600(1-3):117-22.
2008: Adcock Ian M; Caramori Gaetano; Chung K Fan
New targets for drug development in asthma.
Lancet 2008;372(9643):1073-87.
2008: Bhavsar P; Hew M; Khorasani N; Torrego A; Barnes P J; Adcock I; Chung K F
Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma.
Thorax 2008;63(9):784-90.
2008: Williams A S; Nath P; Leung S-Y; Khorasani N; McKenzie A N J; Adcock I M; Chung K F
Modulation of ozone-induced airway hyperresponsiveness and inflammation by interleukin-13.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(3):571-8.
2008: Adcock Ian M; Barnes Peter J
Molecular mechanisms of corticosteroid resistance.
Chest 2008;134(2):394-401.
2008: Enesa Karine; Ito Kazuhiro; Luong Le A; Thorbjornsen Ingvild; Phua Chee; To Yasuo; Dean Jonathan; Haskard Dorian O; Boyle Joseph; Adcock Ian; Evans Paul C
Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms.
The Journal of biological chemistry 2008;283(27):18582-90.
2008: Chung K F; Adcock I M
Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;31(6):1334-56.
2008: Ahmad Tehireem; Barnes Peter J; Adcock Ian M
Overcoming steroid insensitivity in smoking asthmatics.
Current opinion in investigational drugs (London, England : 2000) 2008;9(5):470-7.
2008: Adcock Ian M; Ford Paul A; Bhavsar Pank; Ahmad Tehireem; Chung Kian Fan
Steroid resistance in asthma: mechanisms and treatment options.
Current allergy and asthma reports 2008;8(2):171-8.
2008: Bhavsar Pankaj; Ahmad Tehireem; Adcock Ian M
The role of histone deacetylases in asthma and allergic diseases.
The Journal of allergy and clinical immunology 2008;121(3):580-4.
2007: Adcock Ian M; Tsaprouni Loukia; Bhavsar Pankaj; Ito Kazuhiro
Epigenetic regulation of airway inflammation.
Current opinion in immunology 2007;19(6):694-700.
2007: Ito Kazuhiro; Charron Catherine E; Adcock Ian M
Impact of protein acetylation in inflammatory lung diseases.
Pharmacology & therapeutics 2007;116(2):249-65.
2007: Tsaprouni L G; Ito K; Adcock I M; Punchard N
Suppression of lipopolysaccharide- and tumour necrosis factor-alpha-induced interleukin (IL)-8 expression by glucocorticoids involves changes in IL-8 promoter acetylation.
Clinical and experimental immunology 2007;150(1):151-7.
2007: Williams Alison S; Leung Sum-Yee; Nath Puneeta; Khorasani Nadia M; Bhavsar Pankaj; Issa Razao; Mitchell Jane A; Adcock Ian M; Chung Kian Fan
Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia.
Journal of applied physiology (Bethesda, Md. : 1985) 2007;103(4):1189-95.
2007: Maneechotesuwan Kittipong; Essilfie-Quaye Sarah; Kharitonov Sergei A; Adcock Ian M; Barnes Peter J
Loss of control of asthma following inhaled corticosteroid withdrawal is associated with increased sputum interleukin-8 and neutrophils.
Chest 2007;132(1):98-105.
2007: Williams Alison S; Issa Razao; Leung Sum Yee; Nath Puneeta; Ferguson Gregory D; Bennett Brydon L; Adcock Ian M; Chung Kian Fan
Attenuation of ozone-induced airway inflammation and hyper-responsiveness by c-Jun NH2 terminal kinase inhibitor SP600125.
The Journal of pharmacology and experimental therapeutics 2007;322(1):351-9.
2007: Issa Razao; Xie Shaoping; Khorasani Nadia; Sukkar Maria; Adcock Ian M; Lee Kang-Yun; Chung Kian Fan
Corticosteroid inhibition of growth-related oncogene protein-alpha via mitogen-activated kinase phosphatase-1 in airway smooth muscle cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):7366-75.
2007: Adcock I; Evans P C
Resolution of Inflammatory Responses: a brief introduction.
Biochemical Society transactions 2007;35(Pt 2):261-2.
2007: Adcock I M
HDAC inhibitors as anti-inflammatory agents.
British journal of pharmacology 2007;150(7):829-31.
2007: Ito Kazuhiro; Caramori Gaetano; Adcock Ian M
Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease.
The Journal of pharmacology and experimental therapeutics 2007;321(1):1-8.
2007: Maneechotesuwan Kittipong; Xin Yao; Ito Kazuhiro; Jazrawi Elen; Lee Kang-Yun; Usmani Omar S; Barnes Peter J; Adcock Ian M
Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2491-8.
2007: Jones Edward; Adcock Ian M; Ahmed Bushra Y; Punchard Neville A
Modulation of LPS stimulated NF-kappaB mediated Nitric Oxide production by PKCepsilon and JAK2 in RAW macrophages.
Journal of inflammation (London, England) 2007;4():23.
2006: Adcock Ian M
Histone deacetylase inhibitors as novel anti-inflammatory agents.
Current opinion in investigational drugs (London, England : 2000) 2006;7(11):966-73.
2006: Vasavda Nisha; Eichholtz Thomas; Takahashi Atsushi; Affleck Karen; Matthews John G; Barnes Peter J; Adcock Ian M
Expression of nonmuscle cofilin-1 and steroid responsiveness in severe asthma.
The Journal of allergy and clinical immunology 2006;118(5):1090-6.
2006: Morello Silvana; Ito Kazuhiro; Yamamura Satoshi; Lee Kang-Yun; Jazrawi Elen; Desouza Patricia; Barnes Peter; Cicala Carla; Adcock Ian M
IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: differential requirement for NF-kappa B binding to the proximal promoter.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):7173-83.
2006: Adcock I M; Lee K-Y
Abnormal histone acetylase and deacetylase expression and function in lung inflammation.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2006;55(8):311-21.
2006: Hew Mark; Bhavsar Pankaj; Torrego Alfons; Meah Sally; Khorasani Nadia; Barnes Peter J; Adcock Ian; Chung Kian Fan
Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma.
American journal of respiratory and critical care medicine 2006;174(2):134-41.
2006: Adcock Ian M; Caramori Gaetano; Ito Kazuhiro
New insights into the molecular mechanisms of corticosteroids actions.
Current drug targets 2006;7(6):649-60.
2006: Barczyk Adam; Pierzchala Wladyslaw; Kon Onn M; Cosio Borja; Adcock Ian M; Barnes Peter J
Cytokine production by bronchoalveolar lavage T lymphocytes in chronic obstructive pulmonary disease.
The Journal of allergy and clinical immunology 2006;117(6):1484-92.
2006: Ito Kazuhiro; Chung K Fian; Adcock Ian M
Update on glucocorticoid action and resistance.
The Journal of allergy and clinical immunology 2006;117(3):522-43.
2006: Adcock Ian M; Chung K Fan; Caramori Gaetano; Ito Kazuhiro
Kinase inhibitors and airway inflammation.
European journal of pharmacology 2006;533(1-3):118-32.
2006: Ito Kazuhiro; Yamamura Satoshi; Essilfie-Quaye Sarah; Cosio Borja; Ito Misako; Barnes Peter J; Adcock Ian M
Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression.
The Journal of experimental medicine 2006;203(1):7-13.
2006: Lee Kang-Yun; Ito Kazuhiro; Hayashi Ryuji; Jazrawi Elen P I; Barnes Peter J; Adcock Ian M
NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):603-15.
2006: Adcock Ian M; Ford Paul; Ito Kazuhiro; Barnes P J
Epigenetics and airways disease.
Respiratory research 2006;7():21.
2005: Adcock Ian M; Ito Kazuhiro; Barnes Peter J
Histone deacetylation: an important mechanism in inflammatory lung diseases.
COPD 2005;2(4):445-55.
2005: Walters Matthew J; Paul-Clark Mark J; McMaster Shaun K; Ito Kazuhiro; Adcock Ian M; Mitchell Jane A
Cigarette smoke activates human monocytes by an oxidant-AP-1 signaling pathway: implications for steroid resistance.
Molecular pharmacology 2005;68(5):1343-53.
2005: Maneechotesuwan Kittipong; Essilfie-Quaye Sarah; Meah Sally; Kelly Claire; Kharitonov Sergei A; Adcock Ian M; Barnes Peter J
Formoterol attenuates neutrophilic airway inflammation in asthma.
Chest 2005;128(4):1936-42.
2005: Usmani Omar S; Ito Kazuhiro; Maneechotesuwan Kittipong; Ito Misako; Johnson Malcolm; Barnes Peter J; Adcock Ian M
Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy.
American journal of respiratory and critical care medicine 2005;172(6):704-12.
2005: Caramori Gaetano; Adcock Ian
Anti-inflammatory mechanisms of glucocorticoids targeting granulocytes.
Current drug targets. Inflammation and allergy 2005;4(4):455-63.
2005: Sharma Rakesh; Bolger Aidan P; Rauchhaus Mathias; von Haehling Stephan; Doehner Wolfram; Adcock Ian M; Barnes Peter J; Poole-Wilson Philip A; Volk Hans-Dieter; Coats Andrew J S; Lim Sam; Anker Stefan D
Cellular endotoxin desensitization in patients with severe chronic heart failure.
European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology 2005;7(5):865-8.
2005: Kerr Jonathan R; Kaushik Narendra; Fear David; Baldwin Don A; Nuwaysir Emile F; Adcock Ian M
Single-nucleotide polymorphisms associated with symptomatic infection and differential human gene expression in healthy seropositive persons each implicate the cytoskeleton, integrin signaling, and oncosuppression in the pathogenesis of human parvovirus B19 infection.
The Journal of infectious diseases 2005;192(2):276-86.
2005: Sharma Rakesh; von Haehling Stephan; Rauchhaus Mathias; Bolger Aidan P; Genth-Zotz Sabine; Doehner Wolfram; Oliver Brian; Poole-Wilson Philip A; Volk Hans-Dieter; Coats Andrew J S; Adcock Ian M; Anker Stefan D
Whole blood endotoxin responsiveness in patients with chronic heart failure: the importance of serum lipoproteins.
European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology 2005;7(4):479-84.
2005: Ito Kazuhiro; Ito Misako; Elliott W Mark; Cosio Borja; Caramori Gaetano; Kon Onn Min; Barczyk Adam; Hayashi Shizu; Adcock Ian M; Hogg James C; Barnes Peter J
Decreased histone deacetylase activity in chronic obstructive pulmonary disease.
The New England journal of medicine 2005;352(19):1967-76.
2005: Wada Hiroo; Kagoshima Masahiko; Ito Kazuhiro; Barnes Peter J; Adcock Ian M
5-Azacytidine suppresses RNA polymerase II recruitment to the SLPI gene.
Biochemical and biophysical research communications 2005;331(1):93-9.
2005: von Haehling Stephan; Genth-Zotz Sabine; Bolger Aidan P; Kalra Paul R; Kemp Michael; Adcock Ian M; Poole-Wilson Philip A; Dietz Rainer; Anker Stefan D
Effect of noradrenaline and isoproterenol on lipopolysaccharide-induced tumor necrosis factor-alpha production in whole blood from patients with chronic heart failure and the role of beta-adrenergic receptors.
The American journal of cardiology 2005;95(7):885-9.
2005: Barnes P J; Adcock I M; Ito K
Histone acetylation and deacetylation: importance in inflammatory lung diseases.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2005;25(3):552-63.
2005: Adcock Ian M; Cosio Borja; Tsaprouni Loukia; Barnes Peter J; Ito Kazuhiro
Redox regulation of histone deacetylases and glucocorticoid-mediated inhibition of the inflammatory response.
Antioxidants & redox signaling 2005;7(1-2):144-52.
2005: Nath Puneeta; Eynott Paul; Leung Sum-Yee; Adcock Ian M; Bennett Brydon L; Chung Kian Fan
Potential role of c-Jun NH2-terminal kinase in allergic airway inflammation and remodelling: effects of SP600125.
European journal of pharmacology 2005;506(3):273-83.
2005: Xie Shaoping; Issa Razao; Sukkar Maria B; Oltmanns Ute; Bhavsar Pankaj K; Papi Alberto; Caramori Gaetano; Adcock Ian; Chung K Fan
Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells.
Respiratory research 2005;6():148.
2005: Adcock Ian M; Ito Kazuhiro
Glucocorticoid pathways in chronic obstructive pulmonary disease therapy.
Proceedings of the American Thoracic Society 2005;2(4):313-9; discussion 340-1.
2004: Caramori Gaetano; Adcock Ian M; Ito Kazuhiro
Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPD.
Current opinion in investigational drugs (London, England : 2000) 2004;5(11):1141-7.
2004: Hayashi Ryuji; Wada Hiroo; Ito Kazuhiro; Adcock Ian M
Effects of glucocorticoids on gene transcription.
European journal of pharmacology 2004;500(1-3):51-62.
2004: Adcock Ian M; Caramori Gaetano
Chemokine receptor inhibitors as a novel option in treatment of asthma.
Current drug targets. Inflammation and allergy 2004;3(3):257-61.
2004: Cosio Borja G; Tsaprouni Loukia; Ito Kazuhiro; Jazrawi Elen; Adcock Ian M; Barnes Peter J
Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages.
The Journal of experimental medicine 2004;200(5):689-95.
2004: Jarai Gabor; Sukkar Maria; Garrett Sarah; Duroudier Nathalie; Westwick John; Adcock Ian; Chung Kian Fan
Effects of interleukin-1beta, interleukin-13 and transforming growth factor-beta on gene expression in human airway smooth muscle using gene microarrays.
European journal of pharmacology 2004;497(3):255-65.
2004: Di Stefano A; Caramori G; Ricciardolo F L M; Capelli A; Adcock I M; Donner C F
Cellular and molecular mechanisms in chronic obstructive pulmonary disease: an overview.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2004;34(8):1156-67.
2004: Di Stefano A; Caramori G; Capelli A; Gnemmi I; Ricciardolo F L; Oates T; Donner C F; Chung K F; Barnes P J; Adcock I M
STAT4 activation in smokers and patients with chronic obstructive pulmonary disease.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;24(1):78-85.
2004: Eynott Paul R; Xu Li; Bennett Brydon L; Noble Alistair; Leung Sum-Yee; Nath Puneeta; Groneberg David A; Adcock Ian M; Chung K Fan
Effect of an inhibitor of Jun N-terminal protein kinase, SP600125, in single allergen challenge in sensitized rats.
Immunology 2004;112(3):446-53.
2004: Cosío Borja G; Mann Buphinder; Ito Kazuhiro; Jazrawi Elen; Barnes Peter J; Chung K Fan; Adcock Ian M
Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma.
American journal of respiratory and critical care medicine 2004;170(2):141-7.
2004: Koch A; Giembycz M; Stirling R G; Lim S; Adcock I; Wassermann K; Erdmann E; Chung K F
Effect of smoking on MAP kinase-induced modulation of IL-8 in human alveolar macrophages.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;23(6):805-12.
2004: Matthews John G; Ito Kazuhiro; Barnes Peter J; Adcock Ian M
Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients.
The Journal of allergy and clinical immunology 2004;113(6):1100-8.
2004: Atzori L; Caramori G; Lim S; Jazrawi E; Donnelly L; Adcock I; Barnes P J; Chung K F
Effect of cigarette smoking on haem-oxygenase expression in alveolar macrophages.
Respiratory medicine 2004;98(6):530-5.
2004: Adcock Ian M; Ito Kazuhiro
Steroid resistance in asthma: a major problem requiring novel solutions or a non-issue?
Current opinion in pharmacology 2004;4(3):257-62.
2004: Lim S; Caramori G; Tomita K; Jazrawi E; Oates T; Chung K F; Barnes P J; Adcock I M
Differential expression of IL-10 receptor by epithelial cells and alveolar macrophages.
Allergy 2004;59(5):505-14.
2004: Koch Andrea; Giembycz Mark; Ito Kazuhiro; Lim Sam; Jazrawi Elen; Barnes Peter J; Adcock Ian; Erdmann Erland; Chung K Fan
Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages.
American journal of respiratory cell and molecular biology 2004;30(3):342-9.
2004: Ito K; Hanazawa T; Tomita K; Barnes P J; Adcock I M
Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration.
Biochemical and biophysical research communications 2004;315(1):240-5.
2004: Barnes Peter J; Ito Kazuhiro; Adcock Ian M
Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase.
Lancet 2004;363(9410):731-3.
2004: Adcock Ian M; Ito Kaz; Barnes Peter J
Glucocorticoids: effects on gene transcription.
Proceedings of the American Thoracic Society 2004;1(3):247-54.
2004: Chung K Fan; Adcock Ian M
Combination therapy of long-acting beta2-adrenoceptor agonists and corticosteroids for asthma.
Treatments in respiratory medicine 2004;3(5):279-89.
2004: Adcock Ian M; Caramori Gaetano
Kinase targets and inhibitors for the treatment of airway inflammatory diseases: the next generation of drugs for severe asthma and COPD?
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2004;18(3):167-80.
2003: Tsaprouni Loukia; Adcock Ian M
13th European Respiratory Society Annual congress.
Expert opinion on investigational drugs 2003;12(12):1995-9.
2003: Eynott Paul R; Nath Puneeta; Leung Sum-Yee; Adcock Ian M; Bennett Brydon L; Chung K Fan
Allergen-induced inflammation and airway epithelial and smooth muscle cell proliferation: role of Jun N-terminal kinase.
British journal of pharmacology 2003;140(8):1373-80.
2003: Barnes Peter J; Adcock Ian M
How do corticosteroids work in asthma?
Annals of internal medicine 2003;139(5 Pt 1):359-70.
2003: Paul-Clark Mark J; Roviezzo Fiorentina; Flower Roderick J; Cirino Giuseppe; Soldato Piero Del; Adcock Ian M; Perretti Mauro
Glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):3245-52.
2003: Adcock Ian M
Glucocorticoids: new mechanisms and future agents.
Current allergy and asthma reports 2003;3(3):249-57.
2003: Tomita K; Barnes P J; Adcock I M
The effect of oxidative stress on histone acetylation and IL-8 release.
Biochemical and biophysical research communications 2003;301(2):572-7.
2003: Kagoshima M; Ito K; Cosio B; Adcock I M
Glucocorticoid suppression of nuclear factor-kappa B: a role for histone modifications.
Biochemical Society transactions 2003;31(Pt 1):60-5.
2003: Kagoshima M; Cosio B; Adcock I M
How signaling pathways interact with gene transcription.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo 2003;59(1):30-7.
2003: Caramori Gaetano; Adcock Ian
Pharmacology of airway inflammation in asthma and COPD.
Pulmonary pharmacology & therapeutics 2003;16(5):247-77.
2002: Adcock Ian M; Maneechotesuwan Kittipong; Usmani Omar
Molecular interactions between glucocorticoids and long-acting beta2-agonists.
The Journal of allergy and clinical immunology 2002;110(6 Suppl):S261-8.
2002: Tsaprouni Loukia G; Ito Kazuhiro; Punchard Neville; Adcock Ian M
Triamcinolone acetonide and dexamethasome suppress TNF-alpha-induced histone H4 acetylation on lysine residues 8 and 12 in mononuclear cells.
Annals of the New York Academy of Sciences 2002;973():481-3.
2002: Adcock I
Novel targets in inflammation research. Report from the joint BIRAs/GREMI meeting at Nottingham University UK on 11th-12th April 2002. British Inflammation Research Association. Groupe de Recherche et d'Etude des Mediateurs de l'Inflammation.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2002;51(10):479-82.
2002: Di Stefano A; Caramori G; Oates T; Capelli A; Lusuardi M; Gnemmi I; Ioli F; Chung K F; Donner C F; Barnes P J; Adcock I M
Increased expression of nuclear factor-kappaB in bronchial biopsies from smokers and patients with COPD.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;20(3):556-63.
2002: Eynott Paul R; Groneberg David A; Caramori Gaetano; Adcock Ian M; Donnelly Louise E; Kharitonov Sergei; Barnes Peter J; Chung K Fan
Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness.
European journal of pharmacology 2002;452(1):123-33.
2002: Tomita Katsuyuki; Caramori Gaetano; Lim Sam; Ito Kazuhiro; Hanazawa Toyoyuki; Oates Timothy; Chiselita Irena; Jazrawi Elen; Chung K Fan; Barnes Peter J; Adcock Ian M
Increased p21(CIP1/WAF1) and B cell lymphoma leukemia-x(L) expression and reduced apoptosis in alveolar macrophages from smokers.
American journal of respiratory and critical care medicine 2002;166(5):724-31.
2002: Bolger Aidan P; Sharma Rakesh; von Haehling Stephan; Doehner Wolfram; Oliver Brian; Rauchhaus Mathias; Coats Andrew J S; Adcock Ian M; Anker Stefan D
Effect of interleukin-10 on the production of tumor necrosis factor-alpha by peripheral blood mononuclear cells from patients with chronic heart failure.
The American journal of cardiology 2002;90(4):384-9.
2002: Ito Kazuhiro; Caramori Gaetano; Lim Sam; Oates Tim; Chung K Fan; Barnes Peter J; Adcock Ian M
Expression and activity of histone deacetylases in human asthmatic airways.
American journal of respiratory and critical care medicine 2002;166(3):392-6.
2002: Ito Kazuhiro; Lim Sam; Caramori Gaetano; Cosio Borja; Chung K Fan; Adcock Ian M; Barnes Peter J
A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8921-6.
2002: Irusen Elvis; Matthews John G; Takahashi Atsushi; Barnes Peter J; Chung Kian F; Adcock Ian M
p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma.
The Journal of allergy and clinical immunology 2002;109(4):649-57.
2002: Tomita Katsuyuki; Lim Sam; Hanazawa Toyoyuki; Usmani Omar; Stirling Rob; Chung K Fan; Barnes Peter J; Adcock Ian M
Attenuated production of intracellular IL-10 and IL-12 in monocytes from patients with severe asthma.
Clinical immunology (Orlando, Fla.) 2002;102(3):258-66.
2002: Adcock Ian M; Chung K Fan
Overview: why are corticosteroids ineffective in COPD?
Current opinion in investigational drugs (London, England : 2000) 2002;3(1):58-60.
2002: Ito Kazuhiro; Adcock Ian M
Histone acetylation and histone deacetylation.
Molecular biotechnology 2002;20(1):99-106.
2001: Kagoshima M; Wilcke T; Ito K; Tsaprouni L; Barnes P J; Punchard N; Adcock I M
Glucocorticoid-mediated transrepression is regulated by histone acetylation and DNA methylation.
European journal of pharmacology 2001;429(1-3):327-34.
2001: Caramori G; Lim S; Ito K; Tomita K; Oates T; Jazrawi E; Chung K F; Barnes P J; Adcock I M
Expression of GATA family of transcription factors in T-cells, monocytes and bronchial biopsies.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2001;18(3):466-73.
2001: Ito K; Jazrawi E; Cosio B; Barnes P J; Adcock I M
p65-activated histone acetyltransferase activity is repressed by glucocorticoids: mifepristone fails to recruit HDAC2 to the p65-HAT complex.
The Journal of biological chemistry 2001;276(32):30208-15.
2001: Chung K F; Adcock I M
Pathophysiological mechanisms of asthma. Application of cell and molecular biology techniques.
Molecular biotechnology 2001;18(3):213-32.
2001: Lim S; Tomita K; Caramori G; Jatakanon A; Oliver B; Keller A; Adcock I; Chung K F; Barnes P J;
Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma.
American journal of respiratory and critical care medicine 2001;164(2):273-6.
2001: Di Stefano A; Capelli A; Lusuardi M; Caramori G; Balbo P; Ioli F; Sacco S; Gnemmi I; Brun P; Adcock I M; Balbi B; Barnes P J; Chung K F; Donner C F
Decreased T lymphocyte infiltration in bronchial biopsies of subjects with severe chronic obstructive pulmonary disease.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2001;31(6):893-902.
2001: Ito K; Lim S; Caramori G; Chung K F; Barnes P J; Adcock I M
Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(6):1110-2.
2001: Finney P A; Donnelly L E; Belvisi M G; Chuang T T; Birrell M; Harris A; Mak J C; Scorer C; Barnes P J; Adcock I M; Giembycz M A
Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha).
British journal of pharmacology 2001;132(6):1261-70.
2001: Adcock I M
Glucocorticoid-regulated transcription factors.
Pulmonary pharmacology & therapeutics 2001;14(3):211-9.
2000: Lim S; Groneberg D; Fischer A; Oates T; Caramori G; Mattos W; Adcock I; Barnes P J; Chung K F
Expression of heme oxygenase isoenzymes 1 and 2 in normal and asthmatic airways: effect of inhaled corticosteroids.
American journal of respiratory and critical care medicine 2000;162(5):1912-8.
2000: Ito K; Barnes P J; Adcock I M
Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12.
Molecular and cellular biology 2000;20(18):6891-903.
2000: Finney P A; Belvisi M G; Donnelly L E; Chuang T T; Mak J C; Scorer C; Barnes P J; Adcock I M; Giembycz M A
Albuterol-induced downregulation of Gsalpha accounts for pulmonary beta(2)-adrenoceptor desensitization in vivo.
The Journal of clinical investigation 2000;106(1):125-35.
2000: Adcock I M; Ito K
Molecular mechanisms of corticosteroid actions.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo 2000;55(3):256-66.
2000: Hart L; Lim S; Adcock I; Barnes P J; Chung K F
Effects of inhaled corticosteroid therapy on expression and DNA-binding activity of nuclear factor kappaB in asthma.
American journal of respiratory and critical care medicine 2000;161(1):224-31.
2000: Chung K F; Adcock I M
Induction of nuclear factor-kappa B by exposure to ozone and inhibition by glucocorticoids.
Methods in enzymology 2000;319():551-62.
2000: Adcock I M
Molecular mechanisms of glucocorticosteroid actions.
Pulmonary pharmacology & therapeutics 2000;13(3):115-26.
1999: Hisada T; Adcock I M; Nasuhara Y; Salmon M; Huang T J; Barnes P J; Chung K F
Inhibition of ozone-induced lung neutrophilia and nuclear factor-kappaB binding activity by vitamin A in rat.
European journal of pharmacology 1999;377(1):63-8.
1999: Nasuhara Y; Adcock I M; Catley M; Barnes P J; Newton R
Differential IkappaB kinase activation and IkappaBalpha degradation by interleukin-1beta and tumor necrosis factor-alpha in human U937 monocytic cells. Evidence for additional regulatory steps in kappaB-dependent transcription.
The Journal of biological chemistry 1999;274(28):19965-72.
1999: Adcock I M; Nasuhara Y; Stevens D A; Barnes P J
Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement.
British journal of pharmacology 1999;127(4):1003-11.
1998: Hart L A; Krishnan V L; Adcock I M; Barnes P J; Chung K F
Activation and localization of transcription factor, nuclear factor-kappaB, in asthma.
American journal of respiratory and critical care medicine 1998;158(5 Pt 1):1585-92.
1998: Wright L C; Seybold J; Robichaud A; Adcock I M; Barnes P J
Phosphodiesterase expression in human epithelial cells.
The American journal of physiology 1998;275(4 Pt 1):L694-700.
1998: Adcock I M; Nasuhari Y; Barnes P J
Role of CBP in glucocorticoid-induced gene repression.
Biochemical Society transactions 1998;26(3):S255.
1998: Seybold J; Newton R; Wright L; Finney P A; Suttorp N; Barnes P J; Adcock I M; Giembycz M A
Induction of phosphodiesterases 3B, 4A4, 4D1, 4D2, and 4D3 in Jurkat T-cells and in human peripheral blood T-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor agonists. Potential role in beta2-adrenoreceptor desensitization.
The Journal of biological chemistry 1998;273(32):20575-88.
1998: Barnes P J; Adcock I M
Transcription factors and asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1998;12(1):221-34.
1998: Newton R; Hart L A; Stevens D A; Bergmann M; Donnelly L E; Adcock I M; Barnes P J
Effect of dexamethasone on interleukin-1beta-(IL-1beta)-induced nuclear factor-kappaB (NF-kappaB) and kappaB-dependent transcription in epithelial cells.
European journal of biochemistry / FEBS 1998;254(1):81-9.
1998: Blease K; Seybold J; Adcock I M; Hellewell P G; Burke-Gaffney A
Interleukin-4 and lipopolysaccharide synergize to induce vascular cell adhesion molecule-1 expression in human lung microvascular endothelial cells.
American journal of respiratory cell and molecular biology 1998;18(5):620-30.
1998: Seldon P M; Stevens D A; Adcock I M; O'Connor B J; Barnes P J; Giembycz M A
Albuterol does not antagonize the inhibitory effect of dexamethasone on monocyte cytokine release.
American journal of respiratory and critical care medicine 1998;157(3 Pt 1):803-9.
1997: Newton R; Stevens D A; Hart L A; Lindsay M; Adcock I M; Barnes P J
Superinduction of COX-2 mRNA by cycloheximide and interleukin-1beta involves increased transcription and correlates with increased NF-kappaB and JNK activation.
FEBS letters 1997;418(1-2):135-8.
1997: Newton R; Kuitert L M; Bergmann M; Adcock I M; Barnes P J
Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta.
Biochemical and biophysical research communications 1997;237(1):28-32.
1997: Liu S F; Haddad E B; Adcock I; Salmon M; Koto H; Gilbey T; Barnes P J; Chung K F
Inducible nitric oxide synthase after sensitization and allergen challenge of Brown Norway rat lung.
British journal of pharmacology 1997;121(7):1241-6.
1997: Webb B L; Lindsay M A; Seybold J; Brand N J; Yacoub M H; Haddad E B; Barnes P J; Adcock I M; Giembycz M A
Identification of the protein kinase C isoenzymes in human lung and airways smooth muscle at the protein and mRNA level.
Biochemical pharmacology 1997;54(1):199-205.
1997: Adcock I M; Newton R; Barnes P J
NF-kappa B involvement in IL-1 beta-induction of GM-CSF and COX-2: inhibition by glucocorticoids does not require I-kappa B.
Biochemical Society transactions 1997;25(2):154S.
1997: Adcock I M
Transcription factors as activators of gene transcription: AP-1 and NF-kappa B.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo 1997;52(2):178-86.
1997: Newton R; Kuitert L M; Slater D M; Adcock I M; Barnes P J
Cytokine induction of cytosolic phospholipase A2 and cyclooxygenase-2 mRNA is suppressed by glucocorticoids in human epithelial cells.
Life sciences 1997;60(1):67-78.
1996: Kuitert L M; Newton R; Barnes N C; Adcock I M; Barnes P J
Eicosanoid mediator expression in mononuclear and polymorphonuclear cells in normal subjects and patients with atopic asthma and cystic fibrosis.
Thorax 1996;51(12):1223-8.
1996: Adcock I M; Gilbey T; Gelder C M; Chung K F; Barnes P J
Glucocorticoid receptor localization in normal and asthmatic lung.
American journal of respiratory and critical care medicine 1996;154(3 Pt 1):771-82.
1996: Adcock I M
Steroid resistance in asthma. Molecular mechanisms.
American journal of respiratory and critical care medicine 1996;154(2 Pt 2):S58-61.
1996: Adcock I M; Brown C R; Barnes P J
Tumour necrosis factor alpha causes retention of activated glucocorticoid receptor within the cytoplasm of A549 cells.
Biochemical and biophysical research communications 1996;225(2):545-50.
1996: Liu S F; Adcock I M; Old R W; Barnes P J; Evans T W
Differential regulation of the constitutive and inducible nitric oxide synthase mRNA by lipopolysaccharide treatment in vivo in the rat.
Critical care medicine 1996;24(7):1219-25.
1996: Gelder C M; Morrison J F; Chung K F; Barnes P J; Adcock I M
T cell receptor repertoire in peripheral blood and bronchial biopsies from normal and asthmatic subjects.
Biochemical Society transactions 1996;24(2):316S.
1996: Gelder C M; Barnes P J; O'Connor B J; Chung K F; Adcock I M
Cytokine mRNA profiles of normal and asthmatic peripheral blood cells and endobronchial biopsies.
Biochemical Society transactions 1996;24(2):315S.
1996: Adcock I M; Barnes P J
Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation.
Biochemical Society transactions 1996;24(2):267S.
1996: Haddad E B; Salmon M; Koto H; Barnes P J; Adcock I; Chung K F
Ozone induction of cytokine-induced neutrophil chemoattractant (CINC) and nuclear factor-kappa b in rat lung: inhibition by corticosteroids.
FEBS letters 1996;379(3):265-8.
1996: Adcock I M; Stevens D A; Barnes P J
Interactions of glucocorticoids and beta 2-agonists.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(1):160-8.
1996: Newton R; Adcock I M; Barnes P J
Superinduction of NF-kappa B by actinomycin D and cycloheximide in epithelial cells.
Biochemical and biophysical research communications 1996;218(2):518-23.
1995: Adcock I M; Lane S J; Brown C R; Lee T H; Barnes P J
Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma.
The Journal of experimental medicine 1995;182(6):1951-8.
1995: Xu W B; Haddad E B; Tsukagoshi H; Adcock I; Barnes P J; Chung K F
Induction of macrophage inflammatory protein 2 gene expression by interleukin 1 beta in rat lung.
Thorax 1995;50(11):1136-40.
1995: Gelder C M; Thomas P S; Yates D H; Adcock I M; Morrison J F; Barnes P J
Cytokine expression in normal, atopic, and asthmatic subjects using the combination of sputum induction and the polymerase chain reaction.
Thorax 1995;50(10):1033-7.
1995: Adcock I M; Peters M J; Brown C R; Stevens D A; Barnes P J
High concentrations of beta-adrenergic agonists inhibit DNA binding of glucocorticoids in human lung in vitro.
Biochemical Society transactions 1995;23(2):217S.
1995: Adcock I M; Lane S J; Brown C R; Peters M J; Lee T H; Barnes P J
Differences in binding of glucocorticoid receptor to DNA in steroid-resistant asthma.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(7):3500-5.
1995: Haddad E B; Salmon M; Sun J; Liu S; Das A; Adcock I; Barnes P J; Chung K F
Dexamethasone inhibits ozone-induced gene expression of macrophage inflammatory protein-2 in rat lung.
FEBS letters 1995;363(3):285-8.
1995: Peters M J; Adcock I M; Brown C R; Barnes P J
Beta-adrenoceptor agonists interfere with glucocorticoid receptor DNA binding in rat lung.
European journal of pharmacology 1995;289(2):275-81.
1995: Adcock I M; Brown C R; Gelder C M; Shirasaki H; Peters M J; Barnes P J
Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells.
The American journal of physiology 1995;268(2 Pt 1):C331-8.
1994: Adcock I M; Brown C R; Shirasaki H; Barnes P J
Effects of dexamethasone on cytokine and phorbol ester stimulated c-Fos and c-Jun DNA binding and gene expression in human lung.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1994;7(12):2117-23.
1994: Kwon O J; Au B T; Collins P D; Adcock I M; Mak J C; Robbins R R; Chung K F; Barnes P J
Tumor necrosis factor-induced interleukin-8 expression in cultured human airway epithelial cells.
The American journal of physiology 1994;267(4 Pt 1):L398-405.
1994: Shirasaki H; Adcock I M; Kwon O J; Nishikawa M; Mak J C; Barnes P J
Agonist-induced up-regulation of platelet-activating factor receptor messenger RNA in human monocytes.
European journal of pharmacology 1994;268(2):263-6.
1994: Shirasaki H; Nishikawa M; Adcock I M; Mak J C; Sakamoto T; Shimizu T; Barnes P J
Expression of platelet-activating factor receptor mRNA in human and guinea pig lung.
American journal of respiratory cell and molecular biology 1994;10(5):533-7.
1994: Adcock I M; Brown C R; Barnes P J
Dexamethasone action on c-fos and c-jun mRNA and protein in human lung.
Biochemical Society transactions 1994;22(2):187S.
1994: Adcock I M; Liu S; Brown C R; Evans T W; Barnes P J
Endotoxin and steroid effects of nitric oxide synthase mRNA expression in rat lung and other tissues.
Biochemical Society transactions 1994;22(2):188S.
1994: Adcock I M; Brown C R; Kwon O; Barnes P J
Oxidative stress induces NF kappa B DNA binding and inducible NOS mRNA in the human epithelial cell line A549.
Biochemical Society transactions 1994;22(2):186S.
1994: Kwon O J; Au B T; Collins P D; Baraniuk J N; Adcock I M; Chung K F; Barnes P J
Inhibition of interleukin-8 expression by dexamethasone in human cultured airway epithelial cells.
Immunology 1994;81(3):389-94.
1994: Adcock I M; Brown C R; Kwon O; Barnes P J
Oxidative stress induces NF kappa B DNA binding and inducible NOS mRNA in human epithelial cells.
Biochemical and biophysical research communications 1994;199(3):1518-24.
1994: Robbins R A; Springall D R; Warren J B; Kwon O J; Buttery L D; Wilson A J; Adcock I M; Riveros-Moreno V; Moncada S; Polak J
Inducible nitric oxide synthase is increased in murine lung epithelial cells by cytokine stimulation.
Biochemical and biophysical research communications 1994;198(3):835-43.
1994: Adcock I M; Shirasaki H; Gelder C M; Peters M J; Brown C R; Barnes P J
The effects of glucocorticoids on phorbol ester and cytokine stimulated transcription factor activation in human lung.
Life sciences 1994;55(14):1147-53.
1993: Barnes P J; Adcock I
Anti-inflammatory actions of steroids: molecular mechanisms.
Trends in pharmacological sciences 1993;14(12):436-41.
1993: Liu S; Adcock I M; Old R W; Barnes P J; Evans T W
Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase mRNA.
Biochemical and biophysical research communications 1993;196(3):1208-13.
1993: Adcock I M; Peters M; Gelder C; Shirasaki H; Brown C R; Barnes P J
Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids.
Journal of molecular endocrinology 1993;11(1):1-7.
1993: Adcock I M; Peters M J; Brown C R; Gelder C M; Barnes P J
Transcription factor interactions in human lung.
Biochemical Society transactions 1993;21 ( Pt 3)(3):277S.

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