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Derek Laver

Research Profile

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Ion Channel Gating

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Jiao Li; Rick Thorne; Dirk F vanHelden; Nicole A Beard; Angela F Dulhunty; Mohammad S Imtiaz; Derek R Laver
ß-Adrenergic stimulation increases RyR2 activity via intracellular Ca2+ and Mg2+ regulation.
Victoria A L Seymour; Marco G Casarotto; John P Curmi; Susan M Howitt; Derek R Laver; M Louise Tierney
Selective modulation of different GABAA receptor isoforms by diazepam and etomidate in hippocampal neurons.
Hyun Seok Hwang; Can Hasdemir; Derek R Laver; Divya Mehra; Kutsal Turhan; Michela Faggioni; Huiyong Yin; Björn C Knollmann
Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia.

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All Publications

2013: Jiao Li; Rick Thorne; Dirk F vanHelden; Nicole A Beard; Angela F Dulhunty; Mohammad S Imtiaz; Derek R Laver
ß-Adrenergic stimulation increases RyR2 activity via intracellular Ca2+ and Mg2+ regulation.
PloS one 2013;8(3):e58334.
2012: Victoria A L Seymour; Marco G Casarotto; John P Curmi; Susan M Howitt; Derek R Laver; M Louise Tierney
Selective modulation of different GABAA receptor isoforms by diazepam and etomidate in hippocampal neurons.
The international journal of biochemistry & cell biology 2012;44(9):1491-500.
2011: Hyun Seok Hwang; Can Hasdemir; Derek R Laver; Divya Mehra; Kutsal Turhan; Michela Faggioni; Huiyong Yin; Björn C Knollmann
Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia.
Circulation. Arrhythmia and electrophysiology 2011;4(2):128-35.
2010: Derek R Laver
Regulation of RyR Channel Gating by Ca(2+), Mg(2+) and ATP.
Current topics in membranes 2010;66C():69-89.
2009: Andrea B Everitt; Victoria A L Seymour; John Curmi; Derek R Laver; Peter W Gage; M Louise Tierney
Protein interactions involving the gamma2 large cytoplasmic loop of GABA(A) receptors modulate conductance.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(12):4361-9.
2009: Derek R Laver
Luminal Ca(2+) activation of cardiac ryanodine receptors by luminal and cytoplasmic domains.
European biophysics journal : EBJ 2009;39(1):19-26.
2008: Derek R Laver; Bonny N Honen
Luminal Mg2+, a key factor controlling RYR2-mediated Ca2+ release: cytoplasmic and luminal regulation modeled in a tetrameric channel.
The Journal of general physiology 2008;132(4):429-46.
2008: Derek R Laver; Bonny N Honen; Graham D Lamb; Noriaki Ikemoto
A domain peptide of the cardiac ryanodine receptor regulates channel sensitivity to luminal Ca2+ via cytoplasmic Ca2+ sites.
European biophysics journal : EBJ 2008;37(4):455-67.
2007: Derek R Laver; Tomoyo Hamada; James D Fessenden; Noriaki Ikemoto
The ryanodine receptor pore blocker neomycin also inhibits channel activity via a previously undescribed high-affinity Ca(2+) binding site.
The Journal of membrane biology 2007;220(1-3):11-20.
2007: Derek R Laver
Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sites.
Clinical and experimental pharmacology & physiology 2007;34(9):889-96.
2007: Derek R Laver
Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sites.
Biophysical journal 2007;92(10):3541-55.
2006: Derek R Laver
Regulation of ryanodine receptors from skeletal and cardiac muscle during rest and excitation.
Clinical and experimental pharmacology & physiology 2006;33(11):1107-13.
2006: Derek R Laver; Katherine M Bradley
Disulfonic stilbene permeation and block of the anion channel from the sarcoplasmic reticulum of rabbit skeletal muscle.
American journal of physiology. Cell physiology 2006;290(6):C1666-77.
2005: Derek R Laver
Coupled calcium release channels and their regulation by luminal and cytosolic ions.
European biophysics journal : EBJ 2005;34(5):359-68.
2005: Nicole A Beard; Marco G Casarotto; Lan Wei; Magdolna Varsányi; Derek R Laver; Angela F Dulhunty
Regulation of ryanodine receptors by calsequestrin: effect of high luminal Ca2+ and phosphorylation.
Biophysical journal 2005;88(5):3444-54.
2005: Claudia S Haarmann; Angela F Dulhunty; Derek R Laver
Regulation of skeletal ryanodine receptors by dihydropyridine receptor II-III loop C-region peptides: relief of Mg2+ inhibition.
The Biochemical journal 2005;387(Pt 2):429-36.
2004: Derek R Laver; Erin R O'Neill; Graham D Lamb
Luminal Ca2+-regulated Mg2+ inhibition of skeletal RyRs reconstituted as isolated channels or coupled clusters.
The Journal of general physiology 2004;124(6):741-58.
2004: Nicole A Beard; Derek R Laver; Angela F Dulhunty
Calsequestrin and the calcium release channel of skeletal and cardiac muscle.
Progress in biophysics and molecular biology 2004;85(1):33-69.
2003: Claudia S Haarmann; Daniel Green; Marco G Casarotto; Derek R Laver; Angela F Dulhunty
The random-coil 'C' fragment of the dihydropyridine receptor II-III loop can activate or inhibit native skeletal ryanodine receptors.
The Biochemical journal 2003;372(Pt 2):305-16.
2003: Erin R O'Neill; Magdalena M Sakowska; Derek R Laver
Regulation of the calcium release channel from skeletal muscle by suramin and the disulfonated stilbene derivatives DIDS, DBDS, and DNDS.
Biophysical journal 2003;84(3):1674-89.
2002: Angela F Dulhunty; Claudia S Haarmann; Daniel Green; Derek R Laver; Philip G Board; Marco G Casarotto
Interactions between dihydropyridine receptors and ryanodine receptors in striated muscle.
Progress in biophysics and molecular biology 2002;79(1-3):45-75.
2002: Nicole A Beard; Magdalena M Sakowska; Angela F Dulhunty; Derek R Laver
Calsequestrin is an inhibitor of skeletal muscle ryanodine receptor calcium release channels.
Biophysical journal 2002;82(1 Pt 1):310-20.
2001: Derek R Laver; G K Lenz; Graham D Lamb
Regulation of the calcium release channel from rabbit skeletal muscle by the nucleotides ATP, AMP, IMP and adenosine.
The Journal of physiology 2001;537(Pt 3):763-78.
2001: Angela F Dulhunty; Derek R Laver; Suzanne M Curtis; Suzy M Pace; Claudia S Haarmann; Esther M Gallant
Characteristics of irreversible ATP activation suggest that native skeletal ryanodine receptors can be phosphorylated via an endogenous CaMKII.
Biophysical journal 2001;81(6):3240-52.
2001: Derek R Laver; G K Lenz; Angela F Dulhunty
Phosphate ion channels in sarcoplasmic reticulum of rabbit skeletal muscle.
The Journal of physiology 2001;535(Pt 3):715-28.
2001: Derek R Laver
The power of single channel recording and analysis: its application to ryanodine receptors in lipid bilayers.
Clinical and experimental pharmacology & physiology 2001;28(8):675-86.
2000: Graham D Lamb; Derek R Laver; D George Stephenson
Questions about adaptation in ryanodine receptors.
The Journal of general physiology 2000;116(6):883-90.
2000: Derek R Laver; K R Eager; L Taoube; Graham D Lamb
Effects of cytoplasmic and luminal pH on Ca(2+) release channels from rabbit skeletal muscle.
Biophysical journal 2000;78(4):1835-51.
2000: S Panter; R Thomson; G de Bruxelles; Derek R Laver; Ben Trevaskis; Michael K Udvardi
Identification with proteomics of novel proteins associated with the peribacteroid membrane of soybean root nodules.
Molecular plant-microbe interactions : MPMI 2000;13(3):325-33.
1999: Angela F Dulhunty; Derek R Laver; Esther M Gallant; Marco G Casarotto; Suzy M Pace; Suzanne Curtis
Activation and inhibition of skeletal RyR channels by a part of the skeletal DHPR II-III loop: effects of DHPR Ser687 and FKBP12.
Biophysical journal 1999;77(1):189-203.
1998: Derek R Laver; Graham D Lamb
Inactivation of Ca2+ release channels (ryanodine receptors RyR1 and RyR2) with rapid steps in [Ca2+] and voltage.
Biophysical journal 1998;74(5):2352-64.
1998: GP Ahern; Derek R Laver
ATP inhibition and rectification of a Ca2+-activated anion channel in sarcoplasmic reticulum of skeletal muscle.
Biophysical journal 1998;74(5):2335-51.
1997: Derek R Laver; VJ Owen; Pauline R Junankar; N L Taske; Angela F Dulhunty; Graham D Lamb
Reduced inhibitory effect of Mg2+ on ryanodine receptor-Ca2+ release channels in malignant hyperthermia.
Biophysical journal 1997;73(4):1913-24.
1997: Derek R Laver; T M Baynes; Angela F Dulhunty
Magnesium inhibition of ryanodine-receptor calcium channels: evidence for two independent mechanisms.
The Journal of membrane biology 1997;156(3):213-29.
1997: S R McCulloch; Derek R Laver; N A Walker
Anion channel activity in the Chara plasma membrane: co-operative subunit phenomena and a model.
Journal of experimental botany 1997;48 Spec No():383-97.
1997: Derek R Laver; C A Cherry; N A Walker
The actions of calmodulin antagonists W-7 and TFP and of calcium on the gating kinetics of the calcium-activated large conductance potassium channel of the chara protoplasmic drop: a substate-sensitive analysis.
The Journal of membrane biology 1997;155(3):263-74.
1997: Derek R Laver; W G Peter
Interpretation of substates in ion channels: unipores or multipores?
Progress in biophysics and molecular biology 1997;67(2-3):99-140.
1996: Derek R Laver; B A Curtis
Response of ryanodine receptor channels to Ca2+ steps produced by rapid solution exchange.
Biophysical journal 1996;71(2):732-41.
1996: Derek R Laver; B A Curtis
Surface potentials measure ion concentrations near lipid bilayers during rapid solution changes.
Biophysical journal 1996;71(2):722-31.
1996: Joseph I Kourie; Derek R Laver; GP Ahern; Angela F Dulhunty
A calcium-activated chloride channel in sarcoplasmic reticulum vesicles from rabbit skeletal muscle.
The American journal of physiology 1996;270(6 Pt 1):C1675-86.
1996: Angela F Dulhunty; Pauline R Junankar; Kevin Eager; GP Ahern; Derek R Laver
Ion channels in the sarcoplasmic reticulum of striated muscle.
Acta physiologica Scandinavica 1996;156(3):375-85.
1996: Joseph I Kourie; Derek R Laver; Pauline R Junankar; Peter W Gage; Angela F Dulhunty
Characteristics of two types of chloride channel in sarcoplasmic reticulum vesicles from rabbit skeletal muscle.
Biophysical journal 1996;70(1):202-21.
1995: Derek R Laver; L D Roden; GP Ahern; Kevin Eager; Pauline R Junankar; Angela F Dulhunty
Cytoplasmic Ca2+ inhibits the ryanodine receptor from cardiac muscle.
The Journal of membrane biology 1995;147(1):7-22.
1994: Derek R Laver; K A Fairley-Grenot
Surface potentials near the mouth of the large-conductance K+ channel from Chara australis: a new method of testing for diffusion-limited ion flow.
The Journal of membrane biology 1994;139(3):149-65.
1994: Derek R Laver
The barrel-stave model as applied to alamethicin and its analogs reevaluated.
Biophysical journal 1994;66(2 Pt 1):355-9.
1992: Derek R Laver
Divalent cation block and competition between divalent and monovalent cations in the large-conductance K+ channel from Chara australis.
The Journal of general physiology 1992;100(2):269-300.
1991: K Fairley; Derek R Laver; N A Walker
Whole-cell and single-channel currents across the plasmalemma of corn shoot suspension cells.
The Journal of membrane biology 1991;121(1):11-22.
1991: Derek R Laver; N A Walker
Activation by Ca2+ and block by divalent ions of the K+ channel in the membrane of cytoplasmic drops from Chara australis.
The Journal of membrane biology 1991;120(2):131-9.
1990: Derek R Laver
Coupling of K(+)-gating and permeation with Ca2+ block in the Ca2(+)-activated K+ channel in Chara australis.
The Journal of membrane biology 1990;118(1):55-67.