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Graeme Laver

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Alexey Khalenkov; W Graeme Laver; Robert G Webster
Detection and isolation of H5N1 influenza virus from large volumes of natural water.
Clarence J Maring; Vincent S Stoll; Chen Zhao; Minghua Sun; Allan C Krueger; Kent D Stewart; Darold L Madigan; Warren M Kati; Yibo Xu; Robert Carrick; Debra A Montgomery; Anita J Kempf-Grote; Kennan Marsh; Akhteruzzaman Molla; Kevin Steffy; Hing L Sham; W Graeme Laver; Yu Gui Gu; Dale J Kempf; William Kohlbrenner
Structure-based characterization and optimization of novel hydrophobic binding interactions in a series of pyrrolidine influenza neuraminidase inhibitors.
Stephen Hanessian; Jianchio Wang; Debra Montgomery; Vincent S Stoll; Kent D Stewart; Warren M Kati; Clarence J Maring; Dale J Kempf; Charles W Hutchins; W Graeme Laver
Design, synthesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm.

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All Publications

2008: Alexey Khalenkov; W Graeme Laver; Robert G Webster
Detection and isolation of H5N1 influenza virus from large volumes of natural water.
Journal of virological methods 2008;149(1):180-3.
2005: Clarence J Maring; Vincent S Stoll; Chen Zhao; Minghua Sun; Allan C Krueger; Kent D Stewart; Darold L Madigan; Warren M Kati; Yibo Xu; Robert Carrick; Debra A Montgomery; Anita J Kempf-Grote; Kennan Marsh; Akhteruzzaman Molla; Kevin Steffy; Hing L Sham; W Graeme Laver; Yu Gui Gu; Dale J Kempf; William Kohlbrenner
Structure-based characterization and optimization of novel hydrophobic binding interactions in a series of pyrrolidine influenza neuraminidase inhibitors.
Journal of medicinal chemistry 2005;48(12):3980-90.
2002: Stephen Hanessian; Jianchio Wang; Debra Montgomery; Vincent S Stoll; Kent D Stewart; Warren M Kati; Clarence J Maring; Dale J Kempf; Charles W Hutchins; W Graeme Laver
Design, synthesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm.
Bioorganic & medicinal chemistry letters 2002;12(23):3425-9.
2002: Upma Gulati; Chi-Ching Hwang; Lalitha Venkatramani; Shelly Gulati; Stephen J Stray; Janis T Lee; W Graeme Laver; Alexey Bochkarev; Adam Zlotnick; Gillian M Air
Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98).
Journal of virology 2002;76(23):12274-80.
2001: Warren M Kati; Debra Montgomery; Clarence J Maring; Vincent S Stoll; Vincent L Giranda; Xiaoqi Chen; W Graeme Laver; William Kohlbrenner; Daniel W Norbeck
Novel alpha- and beta-amino acid inhibitors of influenza virus neuraminidase.
Antimicrobial agents and chemotherapy 2001;45(9):2563-70.
2001: Gary T Wang; Yuanwei Chen; Sanyi Wang; Robert Gentles; Thomas J Sowin; Warren M Kati; Steven W Muchmore; Vincent L Giranda; Kent Stewart; Hing L Sham; Dale J Kempf; W Graeme Laver
Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores.
Journal of medicinal chemistry 2001;44(8):1192-201.
1999: Joseph Colacino; Kirk Staschke; W Graeme Laver
Approaches and strategies for the treatment of influenza virus infections.
Antiviral chemistry & chemotherapy 1999;10(4):155-85.
1998: Warren M Kati; Ayda Saldivar; F Mohamadi; Hing L Sham; W Graeme Laver; William Kohlbrenner
GS4071 is a slow-binding inhibitor of influenza neuraminidase from both A and B strains.
Biochemical and biophysical research communications 1998;244(2):408-13.
1997: Pooran Chand; Yarlagadda S Babu; Shanta Bantia; N Chu; LB Cole; Pravin L Kotian; W Graeme Laver; JA Montgomery; V P Pathak; S L Petty; D P Shrout; David A Walsh; GM Walsh
Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design.
Journal of medicinal chemistry 1997;40(25):4030-52.
1997: Joseph Colacino; Nikolay Y Chirgadze; E Garman; K G Murti; R J Loncharich; A J Baxter; Kirk Staschke; W Graeme Laver
A single sequence change destabilizes the influenza virus neuraminidase tetramer.
Virology 1997;236(1):66-75.
1997: Joseph Colacino; W Graeme Laver; Gillian M Air
Selection of influenza A and B viruses for resistance to 4-guanidino-Neu5Ac2en in cell culture.
The Journal of infectious diseases 1997;176 Suppl 1():S66-8.
1997: EA Sudbeck; Mark J Jedrzejas; S Singh; Wayne J Brouillette; Gillian M Air; W Graeme Laver; Yarlagadda S Babu; Shanta Bantia; Pooran Chand; N Chu; JA Montgomery; David A Walsh; Ming Luo
Guanidinobenzoic acid inhibitors of influenza virus neuraminidase.
Journal of molecular biology 1997;267(3):584-94.
1996: S J Crennell; E F Garman; C Philippon; A Vasella; W Graeme Laver; E R Vimr; Garry L Taylor
The structures of Salmonella typhimurium LT2 neuraminidase and its complexes with three inhibitors at high resolution.
Journal of molecular biology 1996;259(2):264-80.
1995: Kirk Staschke; Joseph Colacino; A J Baxter; G M Air; A Bansal; William J Hornback; J E Munroe; W Graeme Laver
Molecular basis for the resistance of influenza viruses to 4-guanidino-Neu5Ac2en.
Virology 1995;214(2):642-6.
1995: S Singh; Mark J Jedrzejas; Gillian M Air; Ming Luo; W Graeme Laver; Wayne J Brouillette
Structure-based inhibitors of influenza virus sialidase. A benzoic acid lead with novel interaction.
Journal of medicinal chemistry 1995;38(17):3217-25.
1995: Gillian M Air; W Graeme Laver
Red cells bound to influenza virus N9 neuraminidase are not released by the N9 neuraminidase activity.
Virology 1995;211(1):278-84.
1995: Ming Luo; Mark J Jedrzejas; S Singh; C L White; Wayne J Brouillette; Gillian M Air; W Graeme Laver
Benzoic acid inhibitors of influenza virus neuraminidase.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 4):504-10.
1995: Mark J Jedrzejas; S Singh; Wayne J Brouillette; W Graeme Laver; Gillian M Air; Ming Luo
Structures of aromatic inhibitors of influenza virus neuraminidase.
Biochemistry 1995;34(10):3144-51.
1995: C L White; M N Janakiraman; W Graeme Laver; C Philippon; A Vasella; Gillian M Air; Ming Luo
A sialic acid-derived phosphonate analog inhibits different strains of influenza virus neuraminidase with different efficiencies.
Journal of molecular biology 1995;245(5):623-34.
1994: Robyn L Malby; W R Tulip; V R Harley; Jennifer L McKimm-Breschkin; W Graeme Laver; R G Webster; Peter M Colman
The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody.
Structure (London, England : 1993) 1994;2(8):733-46.
1994: M N Janakiraman; C L White; W Graeme Laver; Gillian M Air; Ming Luo
Structure of influenza virus neuraminidase B/Lee/40 complexed with sialic acid and a dehydro analog at 1.8-A resolution: implications for the catalytic mechanism.
Biochemistry 1994;33(27):8172-9.
1994: T Saito; G Taylor; W Graeme Laver; Yoshihiro Kawaoka; Robert G Webster
Antigenicity of the N8 influenza A virus neuraminidase: existence of an epitope at the subunit interface of the neuraminidase.
Journal of virology 1994;68(3):1790-6.
1993: S J Crennell; E F Garman; W Graeme Laver; E R Vimr; Garry L Taylor
Crystal structure of a bacterial sialidase (from Salmonella typhimurium LT2) shows the same fold as an influenza virus neuraminidase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):9852-6.
1993: P Bossart-Whitaker; Mike Carson; Yarlagadda S Babu; C D Smith; W Graeme Laver; Gillian M Air
Three-dimensional structure of influenza A N9 neuraminidase and its complex with the inhibitor 2-deoxy 2,3-dehydro-N-acetyl neuraminic acid.
Journal of molecular biology 1993;232(4):1069-83.
1993: K Gopal Murti; Toru Takimoto; W Graeme Laver; Allen Portner
Crystals of hemagglutinin-neuraminidase of parainfluenza virus contain triple-stranded helices.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(4):1523-5.
1992: Toru Takimoto; W Graeme Laver; K Gopal Murti; Allen Portner
Crystallization of biologically active hemagglutinin-neuraminidase glycoprotein dimers proteolytically cleaved from human parainfluenza virus type 1.
Journal of virology 1992;66(12):7597-600.
1992: W R Tulip; Joseph N Varghese; R G Webster; W Graeme Laver; Peter M Colman
Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface.
Journal of molecular biology 1992;227(1):149-59.
1992: W R Tulip; Joseph N Varghese; W Graeme Laver; R G Webster; Peter M Colman
Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex.
Journal of molecular biology 1992;227(1):122-48.
1992: Ming Luo; W Graeme Laver; Gillian M Air
Unusual diffraction of type B influenza virus neuraminidase crystals.
Acta crystallographica. Section A, Foundations of crystallography 1992;48 ( Pt 3)():263-6.
1991: W R Tulip; Joseph N Varghese; A T Baker; A van Donkelaar; W Graeme Laver; R G Webster; Peter M Colman
Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.
Journal of molecular biology 1991;221(2):487-97.
1991: David C Jackson; Brendan S Crabb; Pantelis Poumbourios; W R Tulip; W Graeme Laver
Three antibody molecules can bind simultaneously to each monomer of the tetramer of influenza virus neuraminidase and the trimer of influenza virus hemagglutinin.
Archives of virology 1991;116(1-4):45-56.
1990: Gillian M Air; W Graeme Laver; R G Webster
Mechanism of antigenic variation in an individual epitope on influenza virus N9 neuraminidase.
Journal of virology 1990;64(12):5797-803.
1990: Y J Lin; Ming Luo; W Graeme Laver; Gillian M Air; C D Smith; R G Webster
New crystalline forms of neuraminidase of type B human influenza virus.
Journal of molecular biology 1990;214(3):639-40.
1990: Gillian M Air; W Graeme Laver; Ming Luo; S J Stray; G Legrone; R G Webster
Antigenic, sequence, and crystal variation in influenza B neuraminidase.
Virology 1990;177(2):578-87.
1990: Gillian M Air; A J Gibbs; W Graeme Laver; R G Webster
Evolutionary changes in influenza B are not primarily governed by antibody selection.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3884-8.
1989: W Graeme Laver; Susan Thompson; K Gopal Murti; Allen Portner
Crystallization of Sendai virus HN protein complexed with monoclonal antibody Fab fragments.
Virology 1989;171(1):291-3.
1989: Peter M Colman; W R Tulip; Joseph N Varghese; PA Tulloch; A T Baker; W Graeme Laver; Gillian M Air; R G Webster
Three-dimensional structures of influenza virus neuraminidase-antibody complexes.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1989;323(1217):511-8.
1989: M C Els; W Graeme Laver; Gillian M Air
Sialic acid is cleaved from glycoconjugates at the cell surface when influenza virus neuraminidases are expressed from recombinant vaccinia viruses.
Virology 1989;170(1):346-51.
1989: W R Tulip; Joseph N Varghese; R G Webster; Gillian M Air; W Graeme Laver; Peter M Colman
Crystal structures of neuraminidase-antibody complexes.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():257-63.
1989: Gillian M Air; W Graeme Laver; R G Webster; M C Els; Ming Luo
Antibody recognition of the influenza virus neuraminidase.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():247-55.
1989: Gillian M Air; W Graeme Laver
The neuraminidase of influenza virus.
Proteins 1989;6(4):341-56.
1988: W Graeme Laver; M Luo; P J Bossart; Yarlagadda S Babu; C Smith; M A Accavitti; PA Tulloch; Gillian M Air
Crystallization and preliminary X-ray analysis of type B influenza virus neuraminidase complexed with antibody Fab fragments.
Virology 1988;167(2):621-4.
1988: Susan Thompson; W Graeme Laver; K Gopal Murti; Allen Portner
Isolation of a biologically active soluble form of the hemagglutinin-neuraminidase protein of Sendai virus.
Journal of virology 1988;62(12):4653-60.
1988: P J Bossart; Yarlagadda S Babu; William J Cook; Gillian M Air; W Graeme Laver
Crystallization and preliminary X-ray analyses of two neuraminidases from influenza B virus strains B/Hong Kong/8/73 and B/Lee/40.
The Journal of biological chemistry 1988;263(13):6421-3.
1988: Robert G Webster; P A Reay; W Graeme Laver
Protection against lethal influenza with neuraminidase.
Virology 1988;164(1):230-7.
1988: Joseph N Varghese; R G Webster; W Graeme Laver; Peter M Colman
Structure of an escape mutant of glycoprotein N2 neuraminidase of influenza virus A/Tokyo/3/67 at 3 A.
Journal of molecular biology 1988;200(1):201-3.
1987: Gillian M Air; R G Webster; P M Colman; W Graeme Laver
Distribution of sequence differences in influenza N9 neuraminidase of tern and whale viruses and crystallization of the whale neuraminidase complexed with antibodies.
Virology 1987;160(2):346-54.
1987: R G Webster; Gillian M Air; D W Metzger; Peter M Colman; Joseph N Varghese; A T Baker; W Graeme Laver
Antigenic structure and variation in an influenza virus N9 neuraminidase.
Journal of virology 1987;61(9):2910-6.
1987: Peter M Colman; W Graeme Laver; Joseph N Varghese; A T Baker; PA Tulloch; Gillian M Air; R G Webster
Three-dimensional structure of a complex of antibody with influenza virus neuraminidase.
Nature 1987;326(6111):358-63.
1987: L R Ritchie; R G Webster; W Graeme Laver; Gillian M Air
Heterogeneity of neuraminidase genetic information in an H1N2 reassortant influenza virus [X-7 (F1)]. Brief report.
Archives of virology 1987;96(3-4):303-8.
1987: A T Baker; Joseph N Varghese; W Graeme Laver; Gillian M Air; Peter M Colman
Three-dimensional structure of neuraminidase of subtype N9 from an avian influenza virus.
Proteins 1987;2(2):111-7.
1986: PA Tulloch; Peter M Colman; P C Davis; W Graeme Laver; R G Webster; Gillian M Air
Electron and X-ray diffraction studies of influenza neuraminidase complexed with monoclonal antibodies.
Journal of molecular biology 1986;190(2):215-25.
1985: Gillian M Air; M C Els; L E Brown; W Graeme Laver; R G Webster
Location of antigenic sites on the three-dimensional structure of the influenza N2 virus neuraminidase.
Virology 1985;145(2):237-48.
1985: M C Els; Gillian M Air; K G Murti; R G Webster; W Graeme Laver
An 18-amino acid deletion in an influenza neuraminidase.
Virology 1985;142(2):241-7.
1983: Joseph N Varghese; W Graeme Laver; Peter M Colman
Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A resolution.
Nature 1983;303(5912):35-40.
1983: Peter M Colman; Joseph N Varghese; W Graeme Laver
Structure of the catalytic and antigenic sites in influenza virus neuraminidase.
Nature 1983;303(5912):41-4.