FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

John Lawrence

Research Profile

Chemicals & Drugs

Co-author Network

Publications

TOP 3
Hyun Bae Kim; Anil Kumar; Lifu Wang; Guang-Hui Liu; Susanna R Keller; John C Lawrence; Brian N Finck; Thurl E Harris
Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors.
Anil Kumar; John C Lawrence; Dae Young Jung; Hwi Jin Ko; Susanna R Keller; Jason K Kim; Mark Magnuson; Thurl E Harris
Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism.
Lifu Wang; John C Lawrence; Thomas W Sturgill; Thurl E Harris
Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of John Lawrence (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2010: Hyun Bae Kim; Anil Kumar; Lifu Wang; Guang-Hui Liu; Susanna R Keller; John C Lawrence; Brian N Finck; Thurl E Harris
Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors.
Molecular and cellular biology 2010;30(12):3126-39.
2010: Anil Kumar; John C Lawrence; Dae Young Jung; Hwi Jin Ko; Susanna R Keller; Jason K Kim; Mark Magnuson; Thurl E Harris
Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism.
Diabetes 2010;59(6):1397-406.
2009: Lifu Wang; John C Lawrence; Thomas W Sturgill; Thurl E Harris
Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR.
The Journal of biological chemistry 2009;284(22):14693-7.
2008: Zhouji Chen; Matthew C Gropler; Jin Norris; John C Lawrence; Thurl E Harris; Brian N Finck
Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(10):1738-44.
2008: Lifu Wang; Thurl E Harris; John C Lawrence
Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation.
The Journal of biological chemistry 2008;283(23):15619-27.
2008: Anil Kumar; Thurl E Harris; Susanna R Keller; Kin M Choi; Mark Magnuson; John C Lawrence
Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity.
Molecular and cellular biology 2008;28(1):61-70.
2007: Lifu Wang; Thurl E Harris; Richard A Roth; John C Lawrence
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding.
The Journal of biological chemistry 2007;282(27):20036-44.
2007: Youngjun Kim; Matthew S Gentry; Thurl E Harris; Sandra E Wiley; John C Lawrence; Jack E Dixon
A conserved phosphatase cascade that regulates nuclear membrane biogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(16):6596-601.
2007: Thurl E Harris; Todd A Huffman; An Chi; Jeffrey Shabanowitz; Donald F Hunt; Anil Kumar; John C Lawrence
Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1.
The Journal of biological chemistry 2007;282(1):277-86.
2006: Brian N Finck; Matthew C Gropler; Zhouji Chen; Teresa C Leone; Michelle A Croce; Thurl E Harris; John C Lawrence; Daniel P Kelly
Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.
Cell metabolism 2006;4(3):199-210.
2006: Lifu Wang; Christopher J Rhodes; John C Lawrence
Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1.
The Journal of biological chemistry 2006;281(34):24293-303.
2006: Thurl E Harris; An Chi; Jeffrey Shabanowitz; Donald F Hunt; Robert E Rhoads; John C Lawrence
mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin.
The EMBO journal 2006;25(8):1659-68.
2005: Thomas H Reynolds; Yunbae Pak; Thurl E Harris; Jill K Manchester; Eugene J Barrett; John C Lawrence
Effects of insulin and transgenic overexpression of UDP-glucose pyrophosphorylase on UDP-glucose and glycogen accumulation in skeletal muscle fibers.
The Journal of biological chemistry 2005;280(7):5510-5.
2005: Lloyd P McMahon; W Yue; Richard J Santen; John C Lawrence
Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex.
Molecular endocrinology (Baltimore, Md.) 2005;19(1):175-83.
2004: Charlotte Hinault; Isabelle Mothe-Satney; Nadine Gautier; John C Lawrence; Emmanuel Van Obberghen
Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(15):1894-6.
2004: Isabelle Mothe-Satney; Nadine Gautier; Charlotte Hinault; John C Lawrence; Emmanuel Van Obberghen
In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids.
The Journal of biological chemistry 2004;279(41):42628-37.
2004: Donovan L Fogt; Shujia Pan; Sukho Lee; Zhenping Ding; Angus Scrimgeour; John C Lawrence; John L Ivy
Effect of glycogen synthase overexpression on insulin-stimulated muscle glucose uptake and storage.
American journal of physiology. Endocrinology and metabolism 2004;286(3):E363-9.
2004: John C Lawrence; Tai-An Lin; Lloyd P McMahon; Kin M Choi
Modulation of the protein kinase activity of mTOR.
Current topics in microbiology and immunology 2004;279():199-213.
2003: Thurl E Harris; John C Lawrence
TOR signaling.
Science's STKE : signal transduction knowledge environment 2003;2003(212):re15.
2003: Gail Ferguson; Isabelle Mothe-Satney; John C Lawrence
Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E.
The Journal of biological chemistry 2003;278(48):47459-65.
2003: Kin M Choi; Lloyd P McMahon; John C Lawrence
Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor.
The Journal of biological chemistry 2003;278(22):19667-73.
2002: Lloyd P McMahon; Kin M Choi; Tai-An Lin; Robert T Abraham; John C Lawrence
The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin.
Molecular and cellular biology 2002;22(21):7428-38.
2002: Thomas H Reynolds; Sue Bodine; John C Lawrence
Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load.
The Journal of biological chemistry 2002;277(20):17657-62.
2002: Todd A Huffman; Isabelle Mothe-Satney; John C Lawrence
Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):1047-52.
2001: Sue Bodine; Trevor N Stitt; Michael Gonzalez; William O Kline; G L Stover; R Bauerlein; Elizabeth Zlotchenko; Angus Scrimgeour; John C Lawrence; David J Glass; George D Yancopoulos
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo.
Nature cell biology 2001;3(11):1014-9.
2001: Nina Raben; M Danon; N Lu; E Lee; L Shliselfeld; Alexander Skurat; Peter J Roach; John C Lawrence; Olimpia Musumeci; Sara Shanske; Salvatore DiMauro; Paul H Plotz
Surprises of genetic engineering: a possible model of polyglucosan body disease.
Neurology 2001;56(12):1739-45.
2001: Y Suzuki; C Lanner; Jae Ho Kim; Pier Giuseppe Vilardo; H Zhang; Jun Yang; L D Cooper; M Steele; A Kennedy; C B Bock; Angus Scrimgeour; John C Lawrence; Anna A DePaoli-Roach
Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL.
Molecular and cellular biology 2001;21(8):2683-94.
2001: John C Lawrence; GJ Brunn
Insulin signaling and the control of PHAS-I phosphorylation.
Progress in molecular and subcellular biology 2001;26():1-31.
2000: Isabelle Mothe-Satney; GJ Brunn; Lloyd P McMahon; Christopher T Capaldo; Robert T Abraham; John C Lawrence
Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies.
The Journal of biological chemistry 2000;275(43):33836-43.
2000: Isabelle Mothe-Satney; D Yang; Patrick Fadden; Timothy A J Haystead; John C Lawrence
Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression.
Molecular and cellular biology 2000;20(10):3558-67.
2000: I Azpiazu; Jill K Manchester; Alexander Skurat; Peter J Roach; John C Lawrence
Control of glycogen synthesis is shared between glucose transport and glycogen synthase in skeletal muscle fibers.
American journal of physiology. Endocrinology and metabolism 2000;278(2):E234-43.
1999: Angus Scrimgeour; Patrick B Allen; Allen Fienberg; Paul Greengard; John C Lawrence
Inhibitor-1 is not required for the activation of glycogen synthase by insulin in skeletal muscle.
The Journal of biological chemistry 1999;274(30):20949-52.
1999: D Yang; GJ Brunn; John C Lawrence
Mutational analysis of sites in the translational regulator, PHAS-I, that are selectively phosphorylated by mTOR.
FEBS letters 1999;453(3):387-90.
1998: PH Scott; John C Lawrence
Attenuation of mammalian target of rapamycin activity by increased cAMP in 3T3-L1 adipocytes.
The Journal of biological chemistry 1998;273(51):34496-501.
1998: Hajime Hosoi; Michael B Dilling; LN Liu; Mary K Danks; T Shikata; A Sekulic; Robert T Abraham; John C Lawrence; Peter J Houghton
Studies on the mechanism of resistance to rapamycin in human cancer cells.
Molecular pharmacology 1998;54(5):815-24.
1998: G Xu; Guim Kwon; Connie A Marshall; Tai-An Lin; John C Lawrence; Michael L McDaniel
Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling.
The Journal of biological chemistry 1998;273(43):28178-84.
1998: Patrick Fadden; Timothy A J Haystead; John C Lawrence
Phosphorylation of the translational regulator, PHAS-I, by protein kinase CK2.
FEBS letters 1998;435(1):105-9.
1998: PH Scott; GJ Brunn; AD Kohn; Richard A Roth; John C Lawrence
Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7772-7.
1998: AD Kohn; A Barthel; Kristina S Kovacina; Annegret Boge; B Wallach; SA Summers; Morris J Birnbaum; PH Scott; John C Lawrence; Richard A Roth
Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.
The Journal of biological chemistry 1998;273(19):11937-43.
1998: G Xu; Connie A Marshall; Tai-An Lin; Guim Kwon; Raghava Munivenkatappa; JR Hill; John C Lawrence; Michael L McDaniel
Insulin mediates glucose-stimulated phosphorylation of PHAS-I by pancreatic beta cells. An insulin-receptor mechanism for autoregulation of protein synthesis by translation.
The Journal of biological chemistry 1998;273(8):4485-91.
1997: GJ Brunn; Patrick Fadden; Timothy A J Haystead; John C Lawrence
The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus.
The Journal of biological chemistry 1997;272(51):32547-50.
1997: GJ Brunn; Christine C Hudson; A Sekulić; J M Williams; Hajime Hosoi; Peter J Houghton; John C Lawrence; Robert T Abraham
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin.
Science (New York, N.Y.) 1997;277(5322):99-101.
1997: Tai-An Lin; John C Lawrence
Control of PHAS-I phosphorylation in 3T3-L1 adipocytes: effects of inhibiting protein phosphatases and the p70S6K signalling pathway.
Diabetologia 1997;40 Suppl 2():S18-24.
1997: PH Scott; John C Lawrence
Insulin activates a PD 098059-sensitive kinase that is involved in the regulation of p70S6K and PHAS-I.
FEBS letters 1997;409(2):171-6.
1997: Patrick Fadden; Timothy A J Haystead; John C Lawrence
Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes.
The Journal of biological chemistry 1997;272(15):10240-7.
1997: John C Lawrence; Peter J Roach
New insights into the role and mechanism of glycogen synthase activation by insulin.
Diabetes 1997;46(4):541-7.
1997: John C Lawrence; Alexander Skurat; Peter J Roach; I Azpiazu; Jill K Manchester
Glycogen synthase: activation by insulin and effect of transgenic overexpression in skeletal muscle.
Biochemical Society transactions 1997;25(1):14-9.
1997: John C Lawrence; Patrick Fadden; Timothy A J Haystead; Tai-An Lin
PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation.
Advances in enzyme regulation 1997;37():239-67.
1996: Tai-An Lin; John C Lawrence
Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes.
The Journal of biological chemistry 1996;271(47):30199-204.
1996: GJ Brunn; J Williams; C Sabers; GJ Wiederrecht; John C Lawrence; Robert T Abraham
Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.
The EMBO journal 1996;15(19):5256-67.
1996: Jill K Manchester; Alexander Skurat; P Roach; S D Hauschka; John C Lawrence
Increased glycogen accumulation in transgenic mice overexpressing glycogen synthase in skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10707-11.
1996: D J Creedon; Eugene M Johnson; John C Lawrence
Mitogen-activated protein kinase-independent pathways mediate the effects of nerve growth factor and cAMP on neuronal survival.
The Journal of biological chemistry 1996;271(34):20713-8.
1996: I Azpiazu; Alan Saltiel; A A DePaoli-Roach; John C Lawrence
Regulation of both glycogen synthase and PHAS-I by insulin in rat skeletal muscle involves mitogen-activated protein kinase-independent and rapamycin-sensitive pathways.
The Journal of biological chemistry 1996;271(9):5033-9.
1996: Scot R Kimball; Leonard S Jefferson; Patrick Fadden; Timothy A J Haystead; John C Lawrence
Insulin and diabetes cause reciprocal changes in the association of eIF-4E and PHAS-I in rat skeletal muscle.
The American journal of physiology 1996;270(2 Pt 1):C705-9.
1995: Tai-An Lin; X Kong; Alan Saltiel; Perry Blackshear; John C Lawrence
Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway.
The Journal of biological chemistry 1995;270(31):18531-8.
1995: Lee M Graves; Karin E Bornfeldt; Gretchen M Argast; Edwin G Krebs; X Kong; Tai-An Lin; John C Lawrence
cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(16):7222-6.
1994: Tai-An Lin; X Kong; Timothy A J Haystead; A Pause; G Belsham; Nahum Sonenberg; John C Lawrence
PHAS-I as a link between mitogen-activated protein kinase and translation initiation.
Science (New York, N.Y.) 1994;266(5185):653-6.
1994: A Pause; G J Belsham; Anne-Claude Gingras; O Donzé; Tai-An Lin; John C Lawrence; Nahum Sonenberg
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.
Nature 1994;371(6500):762-7.
1994: Timothy A J Haystead; C M Haystead; C Hu; Tai-An Lin; John C Lawrence
Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes.
The Journal of biological chemistry 1994;269(37):23185-91.
1994: Tai-An Lin; John C Lawrence
Activation of ribosomal protein S6 kinases does not increase glycogen synthesis or glucose transport in rat adipocytes.
The Journal of biological chemistry 1994;269(33):21255-61.
1994: Jill K Manchester; X Kong; OH Lowry; John C Lawrence
Ras signaling in the activation of glucose transport by insulin.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4644-8.
1994: X Kong; Jill K Manchester; Stanley Salmons; John C Lawrence
Glucose transporters in single skeletal muscle fibers. Relationship to hexokinase and regulation by contractile activity.
The Journal of biological chemistry 1994;269(17):12963-7.
1994: C Hu; S Pang; X Kong; M Velleca; John C Lawrence
Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3730-4.
1994: John C Lawrence; J N Zhang
Control of glycogen synthase and phosphorylase by amylin in rat skeletal muscle. Hormonal effects on the phosphorylation of phosphorylase and on the distribution of phosphate in the synthase subunit.
The Journal of biological chemistry 1994;269(15):11595-600.
1994: Jill K Manchester; X Kong; Jeanne M Nerbonne; OH Lowry; John C Lawrence
Glucose transport and phosphorylation in single cardiac myocytes: rate-limiting steps in glucose metabolism.
The American journal of physiology 1994;266(3 Pt 1):E326-33.
1993: B R Sevetson; X Kong; John C Lawrence
Increasing cAMP attenuates activation of mitogen-activated protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):10305-9.
1992: John C Lawrence; R C Piper; L J Robinson; D E James
GLUT4 facilitates insulin stimulation and cAMP-mediated inhibition of glucose transport.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(8):3493-7.