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Gunhild Layer

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Anna-Lena Kaufholz; Gunhild Layer; Thomas Lendrihas; Martina Jahn; Gloria C Ferreira; Vanessa Hering; Gregory A Hunter; Dieter Jahn
Aminolaevulinic acid synthase of Rhodobacter capsulatus: high-resolution kinetic investigation of the structural basis for substrate binding and catalysis.
Sonja Storbeck; Sayantan Saha; Dirk W Heinz; Björn U Klink; Joern Krausze; Gunhild Layer
Crystal structure of the heme d1 biosynthesis enzyme NirE in complex with its substrate reveals new insights into the catalytic mechanism of S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferases.
Gunhild Layer; Joachim Reichelt; Dieter Jahn; Dirk W Heinz
Structure and function of enzymes in heme biosynthesis.

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All Publications

2013: Anna-Lena Kaufholz; Gunhild Layer; Thomas Lendrihas; Martina Jahn; Gloria C Ferreira; Vanessa Hering; Gregory A Hunter; Dieter Jahn
Aminolaevulinic acid synthase of Rhodobacter capsulatus: high-resolution kinetic investigation of the structural basis for substrate binding and catalysis.
The Biochemical journal 2013;451(2):205-16.
2011: Sonja Storbeck; Sayantan Saha; Dirk W Heinz; Björn U Klink; Joern Krausze; Gunhild Layer
Crystal structure of the heme d1 biosynthesis enzyme NirE in complex with its substrate reveals new insights into the catalytic mechanism of S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferases.
The Journal of biological chemistry 2011;286(30):26754-67.
2010: Gunhild Layer; Joachim Reichelt; Dieter Jahn; Dirk W Heinz
Structure and function of enzymes in heme biosynthesis.
Protein science : a publication of the Protein Society 2010;19(6):1137-61.
2010: Sonja Storbeck; Sarah Rolfes; Evelyne Raux-Deery; Martin J Warren; Dieter Jahn; Gunhild Layer
A novel pathway for the biosynthesis of heme in Archaea: genome-based bioinformatic predictions and experimental evidence.
Archaea (Vancouver, B.C.) 2010;2010():175050.
2010: Katrin Rand; Claudia Noll; Hans Martin Schiebel; Dorit Kemken; Thomas Dülcks; Markus Kalesse; Dirk W Heinz; Gunhild Layer
The oxygen-independent coproporphyrinogen III oxidase HemN utilizes harderoporphyrinogen as a reaction intermediate during conversion of coproporphyrinogen III to protoporphyrinogen IX.
Biological chemistry 2010;391(1):55-63.
2009: Sonja Storbeck; Johannes Walther; Judith Müller; Vina Parmar; Hans Martin Schiebel; Dorit Kemken; Thomas Dülcks; Martin J Warren; Gunhild Layer
The Pseudomonas aeruginosa nirE gene encodes the S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase required for heme d(1) biosynthesis.
The FEBS journal 2009;276(20):5973-82.
2006: Gunhild Layer; Antonio J Pierik; Matthias Trost; Stephen E J Rigby; Helen K Leech; Katrin Grage; Daniela Breckau; Isabel Astner; Lothar Jänsch; Peter Heathcote; Martin J Warren; Dirk W Heinz; Dieter Jahn
The substrate radical of Escherichia coli oxygen-independent coproporphyrinogen III oxidase HemN.
The Journal of biological chemistry 2006;281(23):15727-34.
2006: Heike Reents; Ines Gruner; Ute Harmening; Lars H Böttger; Gunhild Layer; Peter Heathcote; Alfred X Trautwein; Dieter Jahn; Elisabeth Härtig
Bacillus subtilis Fnr senses oxygen via a [4Fe-4S] cluster coordinated by three cysteine residues without change in the oligomeric state.
Molecular microbiology 2006;60(6):1432-45.
2005: Gunhild Layer; Eric Kervio; Gaby Morlock; Dirk W Heinz; Dieter Jahn; Janos Retey; Wolf-Dieter Schubert
Structural and functional comparison of HemN to other radical SAM enzymes.
Biological chemistry 2005;386(10):971-80.
2005: Gunhild Layer; Katrin Grage; Thomas Teschner; Volker Schünemann; Daniela Breckau; Ava Masoumi; Martina Jahn; Peter Heathcote; Alfred X Trautwein; Dieter Jahn
Radical S-adenosylmethionine enzyme coproporphyrinogen III oxidase HemN: functional features of the [4Fe-4S] cluster and the two bound S-adenosyl-L-methionines.
The Journal of biological chemistry 2005;280(32):29038-46.
2004: Gunhild Layer; Dirk W Heinz; Dieter Jahn; Wolf-Dieter Schubert
Structure and function of radical SAM enzymes.
Current opinion in chemical biology 2004;8(5):468-76.
2003: Gunhild Layer; Jürgen Moser; Dirk W Heinz; Dieter Jahn; Wolf-Dieter Schubert
Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes.
The EMBO journal 2003;22(23):6214-24.
2003: Daniela Breckau; Esther Mahlitz; Anselm Sauerwald; Gunhild Layer; Dieter Jahn
Oxygen-dependent coproporphyrinogen III oxidase (HemF) from Escherichia coli is stimulated by manganese.
The Journal of biological chemistry 2003;278(47):46625-31.
2002: Gunhild Layer; Knut Verfürth; Esther Mahlitz; Dieter Jahn
Oxygen-independent coproporphyrinogen-III oxidase HemN from Escherichia coli.
The Journal of biological chemistry 2002;277(37):34136-42.