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Mitchell Lazar

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
10
Guenther, Matthew
10
Steppan, Claire
9
Rangwala, Shamina
9
Lehrke, Michael
9
Zhang, Jinsong
8
Reginato, MJ
8
Chin, William
6
Ahima, Rexford
6
Hodin, Richard
6
Banerjee, Ronadip
6
Wu, Gary
5
Yin, Lei
5
Yu, Jiujiu
5
Ishizuka, Takahiro
5
Bailey, ST

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Publications

TOP 3
Wu Nan; Yin Lei; Hanniman Elyisha A; Joshi Shree; Lazar Mitchell A
Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha.
Lefterova Martina I; Mullican Shannon E; Tomaru Takuya; Qatanani Mohammed; Schupp Michael; Lazar Mitchell A
Endoplasmic reticulum stress regulates adipocyte resistin expression.
Lefterova Martina I; Lazar Mitchell A
New developments in adipogenesis.

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All Publications

2009: Wu Nan; Yin Lei; Hanniman Elyisha A; Joshi Shree; Lazar Mitchell A
Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha.
Genes & development 2009;23(18):2201-9.
2009: Lefterova Martina I; Mullican Shannon E; Tomaru Takuya; Qatanani Mohammed; Schupp Michael; Lazar Mitchell A
Endoplasmic reticulum stress regulates adipocyte resistin expression.
Diabetes 2009;58(8):1879-86.
2009: Lefterova Martina I; Lazar Mitchell A
New developments in adipogenesis.
Trends in endocrinology and metabolism: TEM 2009;20(3):107-14.
2009: Schupp Michael; Cristancho Ana G; Lefterova Martina I; Hanniman Elyisha A; Briggs Erika R; Steger David J; Qatanani Mohammed; Curtin Joshua C; Schug Jonathan; Ochsner Scott A; McKenna Neil J; Lazar Mitchell A
Re-expression of GATA2 cooperates with peroxisome proliferator-activated receptor-gamma depletion to revert the adipocyte phenotype.
The Journal of biological chemistry 2009;284(14):9458-64.
2009: Tomaru Takuya; Steger David J; Lefterova Martina I; Schupp Michael; Lazar Mitchell A
Adipocyte-specific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor gamma and CCAAT/enhancer-binding proteins.
The Journal of biological chemistry 2009;284(10):6116-25.
2009: Schupp Michael; Lefterova Martina I; Janke Jürgen; Leitner Kirstin; Cristancho Ana G; Mullican Shannon E; Qatanani Mohammed; Szwergold Nava; Steger David J; Curtin Joshua C; Kim Roy J; Suh Moo-Jin; Albert Martin R; Engeli Stefan; Gudas Lorraine J; Lazar Mitchell A
Retinol saturase promotes adipogenesis and is downregulated in obesity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(4):1105-10.
2008: Lefterova Martina I; Zhang Yong; Steger David J; Schupp Michael; Schug Jonathan; Cristancho Ana; Feng Dan; Zhuo David; Stoeckert Christian J; Liu X Shirley; Lazar Mitchell A
PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale.
Genes & development 2008;22(21):2941-52.
2008: Phelan Caroline A; Weaver Joseph M; Steger David J; Joshi Shree; Maslany Jeffrey T; Collins Jon L; Zuercher William J; Willson Timothy M; Walker Max; Jaye Michael; Lazar Mitchell A
Selective partial agonism of liver X receptor alpha is related to differential corepressor recruitment.
Molecular endocrinology (Baltimore, Md.) 2008;22(10):2241-9.
2008: Ahima Rexford S; Lazar Mitchell A
Adipokines and the peripheral and neural control of energy balance.
Molecular endocrinology (Baltimore, Md.) 2008;22(5):1023-31.
2008: Steger David J; Lefterova Martina I; Ying Lei; Stonestrom Aaron J; Schupp Michael; Zhuo David; Vakoc Adam L; Kim Ja-Eun; Chen Junjie; Lazar Mitchell A; Blobel Gerd A; Vakoc Christopher R
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells.
Molecular and cellular biology 2008;28(8):2825-39.
2008: Wang Jing; Lazar Mitchell A
Bifunctional role of Rev-erbalpha in adipocyte differentiation.
Molecular and cellular biology 2008;28(7):2213-20.
2008: Shearer Barry G; Steger David J; Way James M; Stanley Thomas B; Lobe David C; Grillot Didier A; Iannone Marie A; Lazar Mitchell A; Willson Timothy M; Billin Andrew N
Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist.
Molecular endocrinology (Baltimore, Md.) 2008;22(2):523-9.
2007: Yin Lei; Wu Nan; Curtin Joshua C; Qatanani Mohammed; Szwergold Nava R; Reid Robert A; Waitt Gregory M; Parks Derek J; Pearce Kenneth H; Wisely G Bruce; Lazar Mitchell A
Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways.
Science (New York, N.Y.) 2007;318(5857):1786-9.
2007: Singhal Neel S; Lazar Mitchell A; Ahima Rexford S
Central resistin induces hepatic insulin resistance via neuropeptide Y.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(47):12924-32.
2007: Schambach Felix; Schupp Michael; Lazar Mitchell A; Reiner Steven L
Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation.
European journal of immunology 2007;37(9):2396-9.
2007: Qatanani Mohammed; Lazar Mitchell A
Mechanisms of obesity-associated insulin resistance: many choices on the menu.
Genes & development 2007;21(12):1443-55.
2007: Schupp Michael; Curtin Joshua C; Kim Roy J; Billin Andrew N; Lazar Mitchell A
A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity.
Molecular pharmacology 2007;71(5):1251-7.
2007: Lazar Mitchell A; Willson Timothy M
Sweet dreams for LXR.
Cell metabolism 2007;5(3):159-61.
2007: Lehrke Michael; Millington Segan C; Lefterova Martina; Cumaranatunge Reshmaal Gomes; Szapary Philippe; Wilensky Robert; Rader Daniel J; Lazar Mitchell A; Reilly Muredach P
CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humans.
Journal of the American College of Cardiology 2007;49(4):442-9.
2006: Qi Yong; Nie Zhenying; Lee Yun-Sik; Singhal Neel S; Scherer Philipp E; Lazar Mitchell A; Ahima Rexford S
Loss of resistin improves glucose homeostasis in leptin deficiency.
Diabetes 2006;55(11):3083-90.
2006: McVay Laila D; Keilbaugh Sue A; Wong Tracie M H; Kierstein Sonja; Shin Marcus E; Lehrke Michael; Lefterova Martina I; Shifflett D Edward; Barnes Sean L; Cominelli Fabio; Cohn Steven M; Hecht Gail; Lazar Mitchell A; Haczku Angela; Wu Gary D
Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis.
The Journal of clinical investigation 2006;116(11):2914-23.
2006: Wang Jing; Yin Lei; Lazar Mitchell A
The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1.
The Journal of biological chemistry 2006;281(45):33842-8.
2006: Yu Jiujiu; Palmer Christine; Alenghat Theresa; Li Yun; Kao Gary; Lazar Mitchell A
The corepressor silencing mediator for retinoid and thyroid hormone receptor facilitates cellular recovery from DNA double-strand breaks.
Cancer research 2006;66(18):9316-22.
2006: Li Yun; Kao Gary D; Garcia Benjamin A; Shabanowitz Jeffrey; Hunt Donald F; Qin Jun; Phelan Caroline; Lazar Mitchell A
A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity.
Genes & development 2006;20(18):2566-79.
2006: Alenghat Theresa; Yu Jiujiu; Lazar Mitchell A
The N-CoR complex enables chromatin remodeler SNF2H to enhance repression by thyroid hormone receptor.
The EMBO journal 2006;25(17):3966-74.
2006: Kim Roy J; Wilson Camella G; Wabitsch Martin; Lazar Mitchell A; Steppan Claire M
HIV protease inhibitor-specific alterations in human adipocyte differentiation and metabolism.
Obesity (Silver Spring, Md.) 2006;14(6):994-1002.
2006: Yin Lei; Wang Jing; Klein Peter S; Lazar Mitchell A
Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock.
Science (New York, N.Y.) 2006;311(5763):1002-5.
2005: Lehrke Michael; Lazar Mitchell A
The many faces of PPARgamma.
Cell 2005;123(6):993-9.
2005: Graveleau Christophe; Zaha Vlad G; Mohajer Arash; Banerjee Ronadip R; Dudley-Rucker Nicole; Steppan Claire M; Rajala Michael W; Scherer Philipp E; Ahima Rexford S; Lazar Mitchell A; Abel E Dale
Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action.
The Journal of biological chemistry 2005;280(36):31679-85.
2005: Lehrke Michael; Pascual Gabriel; Glass Christopher K; Lazar Mitchell A
Gaining weight: the Keystone Symposium on PPAR and LXR.
Genes & development 2005;19(15):1737-42.
2005: Chui Patricia C; Guan Hong-Ping; Lehrke Michael; Lazar Mitchell A
PPARgamma regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1.
The Journal of clinical investigation 2005;115(8):2244-56.
2005: Yin Lei; Lazar Mitchell A
The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene.
Molecular endocrinology (Baltimore, Md.) 2005;19(6):1452-9.
2005: Ishizuka Takahiro; Lazar Mitchell A
The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor.
Molecular endocrinology (Baltimore, Md.) 2005;19(6):1443-51.
2005: Lehrke Michael; Lebherz Corinna; Millington Segan C; Guan Hong-Ping; Millar John; Rader Daniel J; Wilson James M; Lazar Mitchell A
Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRalpha.
Cell metabolism 2005;1(5):297-308.
2005: Hartman Helen B; Yu Jiujiu; Alenghat Theresa; Ishizuka Takahiro; Lazar Mitchell A
The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3.
EMBO reports 2005;6(5):445-51.
2005: Reilly Muredach P; Lehrke Michael; Wolfe Megan L; Rohatgi Anand; Lazar Mitchell A; Rader Daniel J
Resistin is an inflammatory marker of atherosclerosis in humans.
Circulation 2005;111(7):932-9.
2005: Steppan Claire M; Wang Juan; Whiteman Eileen L; Birnbaum Morris J; Lazar Mitchell A
Activation of SOCS-3 by resistin.
Molecular and cellular biology 2005;25(4):1569-75.
2005: Guan Hong-Ping; Ishizuka Takahiro; Chui Patricia C; Lehrke Michael; Lazar Mitchell A
Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes.
Genes & development 2005;19(4):453-61.
2005: Lazar Mitchell A
PPAR gamma, 10 years later.
Biochimie 2005;87(1):9-13.
2005: Lazar Mitchell A
How obesity causes diabetes: not a tall tale.
Science (New York, N.Y.) 2005;307(5708):373-5.
2004: Lehrke Michael; Reilly Muredach P; Millington Segan C; Iqbal Nayyar; Rader Daniel J; Lazar Mitchell A
An inflammatory cascade leading to hyperresistinemia in humans.
PLoS medicine 2004;1(2):e45.
2004: Artis David; Wang Mei Lun; Keilbaugh Sue A; He Weimian; Brenes Mario; Swain Gary P; Knight Pamela A; Donaldson Deborah D; Lazar Mitchell A; Miller Hugh R P; Schad Gerhard A; Scott Phillip; Wu Gary D
RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(37):13596-600.
2004: Rangwala Shamina M; Rich A Sophie; Rhoades Ben; Shapiro Jennifer S; Obici Silvana; Rossetti Luciano; Lazar Mitchell A
Abnormal glucose homeostasis due to chronic hyperresistinemia.
Diabetes 2004;53(8):1937-41.
2004: Rangwala Shamina M; Lazar Mitchell A
Peroxisome proliferator-activated receptor gamma in diabetes and metabolism.
Trends in pharmacological sciences 2004;25(6):331-6.
2004: Hug Bruce A; Lazar Mitchell A
ETO interacting proteins.
Oncogene 2004;23(24):4270-4.
2004: Steppan Claire M; Lazar Mitchell A
The current biology of resistin.
Journal of internal medicine 2004;255(4):439-47.
2004: Banerjee Ronadip R; Rangwala Shamina M; Shapiro Jennifer S; Rich A Sophie; Rhoades Ben; Qi Yong; Wang Juan; Rajala Michael W; Pocai Alessandro; Scherer Phillipp E; Steppan Claire M; Ahima Rexford S; Obici Silvana; Rossetti Luciano; Lazar Mitchell A
Regulation of fasted blood glucose by resistin.
Science (New York, N.Y.) 2004;303(5661):1195-8.
2004: Fanelli Mirco; Fantozzi Anna; De Luca Pasquale; Caprodossi Sara; Matsuzawa Shu-ichi; Lazar Mitchell A; Pelicci Pier Giuseppe; Minucci Saverio
The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome.
The Journal of biological chemistry 2004;279(7):5374-9.
2004: Lazar Mitchell A
East meets West: an herbal tea finds a receptor.
The Journal of clinical investigation 2004;113(1):23-5.
2004: Hug Bruce A; Ahmed Nazia; Robbins Jonathan A; Lazar Mitchell A
A chromatin immunoprecipitation screen reveals protein kinase Cbeta as a direct RUNX1 target gene.
The Journal of biological chemistry 2004;279(2):825-30.
2003: He Weimian; Wang Mei-Lun; Jiang Han-Qing; Steppan Claire M; Shin Marcus E; Thurnheer M Christine; Cebra John J; Lazar Mitchell A; Wu Gary D
Bacterial colonization leads to the colonic secretion of RELMbeta/FIZZ2, a novel goblet cell-specific protein.
Gastroenterology 2003;125(5):1388-97.
2003: Rangwala Shamina M; Rhoades Ben; Shapiro Jennifer S; Rich A Sophie; Kim Jason K; Shulman Gerald I; Kaestner Klaus H; Lazar Mitchell A
Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity.
Developmental cell 2003;5(4):657-63.
2003: Lazar Mitchell A
Thyroid hormone action: a binding contract.
The Journal of clinical investigation 2003;112(4):497-9.
2003: Ishizuka Takahiro; Lazar Mitchell A
The N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptor.
Molecular and cellular biology 2003;23(15):5122-31.
2003: Yu Jiujiu; Li Yun; Ishizuka Takahiro; Guenther Matthew G; Lazar Mitchell A
A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation.
The EMBO journal 2003;22(13):3403-10.
2003: Banerjee Ronadip R; Lazar Mitchell A
Resistin: molecular history and prognosis.
Journal of molecular medicine (Berlin, Germany) 2003;81(4):218-26.
2003: Kao Gary D; McKenna W Gillies; Guenther Matthew G; Muschel Ruth J; Lazar Mitchell A; Yen Tim J
Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response.
The Journal of cell biology 2003;160(7):1017-27.
2003: Lazar Mitchell A
Nuclear receptor corepressors.
Nuclear receptor signaling 2003;1():e001.
2002: Guenther Matthew G; Yu Jiujiu; Kao Gary D; Yen Tim J; Lazar Mitchell A
Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex.
Genes & development 2002;16(24):3130-5.
2002: Guan Hong-Ping; Li Yong; Jensen Mette Valentin; Newgard Christopher B; Steppan Claire M; Lazar Mitchell A
A futile metabolic cycle activated in adipocytes by antidiabetic agents.
Nature medicine 2002;8(10):1122-8.
2002: Wang Y Lynn; Frauwirth Kenneth A; Rangwala Shamina M; Lazar Mitchell A; Thompson Craig B
Thiazolidinedione activation of peroxisome proliferator-activated receptor gamma can enhance mitochondrial potential and promote cell survival.
The Journal of biological chemistry 2002;277(35):31781-8.
2002: Hug Bruce A; Lee Samuel Y D; Kinsler Erron L; Zhang Jinsong; Lazar Mitchell A
Cooperative function of Aml1-ETO corepressor recruitment domains in the expansion of primary bone marrow cells.
Cancer research 2002;62(10):2906-12.
2002: Li Yong; Lazar Mitchell A
Differential gene regulation by PPARgamma agonist and constitutively active PPARgamma2.
Molecular endocrinology (Baltimore, Md.) 2002;16(5):1040-8.
2002: Hartman Helen B; Hu Xiao; Tyler Keala X; Dalal Chiraj K; Lazar Mitchell A
Mechanisms regulating adipocyte expression of resistin.
The Journal of biological chemistry 2002;277(22):19754-61.
2002: Rangwala Shamina M; Lazar Mitchell A
The dawn of the SPPARMs?
Science's STKE : signal transduction knowledge environment 2002;2002(121):pe9.
2002: Fischle Wolfgang; Dequiedt Franck; Hendzel Michael J; Guenther Matthew G; Lazar Mitchell A; Voelter Wolfgang; Verdin Eric
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.
Molecular cell 2002;9(1):45-57.
2002: Lazar Mitchell A
Becoming fat.
Genes & development 2002;16(1):1-5.
2002: Steppan Claire M; Lazar Mitchell A
Resistin and obesity-associated insulin resistance.
Trends in endocrinology and metabolism: TEM 2002;13(1):18-23.
2001: Lewis J D; Lichtenstein G R; Stein R B; Deren J J; Judge T A; Fogt F; Furth E E; Demissie E J; Hurd L B; Su C G; Keilbaugh S A; Lazar M A; Wu G D
An open-label trial of the PPAR-gamma ligand rosiglitazone for active ulcerative colitis.
The American journal of gastroenterology 2001;96(12):3323-8.
2001: Guenther M G; Barak O; Lazar M A
The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3.
Molecular and cellular biology 2001;21(18):6091-101.
2001: Phiel C J; Zhang F; Huang E Y; Guenther M G; Lazar M A; Klein P S
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen.
The Journal of biological chemistry 2001;276(39):36734-41.
2001: Banerjee R R; Lazar M A
Dimerization of resistin and resistin-like molecules is determined by a single cysteine.
The Journal of biological chemistry 2001;276(28):25970-3.
2001: Hu X; Li Y; Lazar M A
Determinants of CoRNR-dependent repression complex assembly on nuclear hormone receptors.
Molecular and cellular biology 2001;21(5):1747-58.
2001: Steppan C M; Brown E J; Wright C M; Bhat S; Banerjee R R; Dai C Y; Enders G H; Silberg D G; Wen X; Wu G D; Lazar M A
A family of tissue-specific resistin-like molecules.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(2):502-6.
2001: Steppan C M; Bailey S T; Bhat S; Brown E J; Banerjee R R; Wright C M; Patel H R; Ahima R S; Lazar M A
The hormone resistin links obesity to diabetes.
Nature 2001;409(6818):307-12.
2001: Lazar M A
Progress in cardiovascular biology: PPAR for the course.
Nature medicine 2001;7(1):23-4.
2001: Zhang J; Hug B A; Huang E Y; Chen C W; Gelmetti V; Maccarana M; Minucci S; Pelicci P G; Lazar M A
Oligomerization of ETO is obligatory for corepressor interaction.
Molecular and cellular biology 2001;21(1):156-63.
2000: Minucci S; Maccarana M; Cioce M; De Luca P; Gelmetti V; Segalla S; Di Croce L; Giavara S; Matteucci C; Gobbi A; Bianchini A; Colombo E; Schiavoni I; Badaracco G; Hu X; Lazar M A; Landsberger N; Nervi C; Pelicci P G
Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.
Molecular cell 2000;5(5):811-20.
2000: Guenther M G; Lane W S; Fischle W; Verdin E; Lazar M A; Shiekhattar R
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.
Genes & development 2000;14(9):1048-57.
2000: Rachez C; Gamble M; Chang C P; Atkins G B; Lazar M A; Freedman L P
The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes.
Molecular and cellular biology 2000;20(8):2718-26.
2000: Gurnell M; Wentworth J M; Agostini M; Adams M; Collingwood T N; Provenzano C; Browne P O; Rajanayagam O; Burris T P; Schwabe J W; Lazar M A; Chatterjee V K
A dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutant is a constitutive repressor and inhibits PPARgamma-mediated adipogenesis.
The Journal of biological chemistry 2000;275(8):5754-9.
2000: Hu X; Lazar M A
Transcriptional repression by nuclear hormone receptors.
Trends in endocrinology and metabolism: TEM 2000;11(1):6-10.
2000: Huang E Y; Zhang J; Miska E A; Guenther M G; Kouzarides T; Lazar M A
Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.
Genes & development 2000;14(1):45-54.
2000: Rangwala S M; Lazar M A
Transcriptional control of adipogenesis.
Annual review of nutrition 2000;20():535-59.
2000: Zhang J; Lazar M A
The mechanism of action of thyroid hormones.
Annual review of physiology 2000;62():439-66.
1999: Hu X; Lazar M A
The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors.
Nature 1999;402(6757):93-6.
1999: Atkins G B; Hu X; Guenther M G; Rachez C; Freedman L P; Lazar M A
Coactivators for the orphan nuclear receptor RORalpha.
Molecular endocrinology (Baltimore, Md.) 1999;13(9):1550-7.
1999: Zhang J; Hu X; Lazar M A
A novel role for helix 12 of retinoid X receptor in regulating repression.
Molecular and cellular biology 1999;19(9):6448-57.
1999: Su C G; Wen X; Bailey S T; Jiang W; Rangwala S M; Keilbaugh S A; Flanigan A; Murthy S; Lazar M A; Wu G D
A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response.
The Journal of clinical investigation 1999;104(4):383-9.
1999: Shao D; Lazar M A
Modulating nuclear receptor function: may the phos be with you.
The Journal of clinical investigation 1999;103(12):1617-8.
1998: Reginato M J; Bailey S T; Krakow S L; Minami C; Ishii S; Tanaka H; Lazar M A
A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties.
The Journal of biological chemistry 1998;273(49):32679-84.
1998: Gelmetti V; Zhang J; Fanelli M; Minucci S; Pelicci P G; Lazar M A
Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.
Molecular and cellular biology 1998;18(12):7185-91.
1998: Shao D; Rangwala S M; Bailey S T; Krakow S L; Reginato M J; Lazar M A
Interdomain communication regulating ligand binding by PPAR-gamma.
Nature 1998;396(6709):377-80.
1998: Zhang J; Guenther M G; Carthew R W; Lazar M A
Proteasomal regulation of nuclear receptor corepressor-mediated repression.
Genes & development 1998;12(12):1775-80.
1998: Grignani F; De Matteis S; Nervi C; Tomassoni L; Gelmetti V; Cioce M; Fanelli M; Ruthardt M; Ferrara F F; Zamir I; Seiser C; Grignani F; Lazar M A; Minucci S; Pelicci P G
Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia.
Nature 1998;391(6669):815-8.
1998: Reginato M J; Krakow S L; Bailey S T; Lazar M A
Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator-activated receptor gamma.
The Journal of biological chemistry 1998;273(4):1855-8.
1997: Zamir I; Dawson J; Lavinsky R M; Glass C K; Rosenfeld M G; Lazar M A
Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14400-5.
1997: Zhang J; Zamir I; Lazar M A
Differential recognition of liganded and unliganded thyroid hormone receptor by retinoid X receptor regulates transcriptional repression.
Molecular and cellular biology 1997;17(12):6887-97.
1997: Harding H P; Atkins G B; Jaffe A B; Seo W J; Lazar M A
Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development.
Molecular endocrinology (Baltimore, Md.) 1997;11(11):1737-46.
1997: Shao D; Lazar M A
Peroxisome proliferator activated receptor gamma, CCAAT/enhancer-binding protein alpha, and cell cycle status regulate the commitment to adipocyte differentiation.
The Journal of biological chemistry 1997;272(34):21473-8.
1997: Zamir I; Zhang J; Lazar M A
Stoichiometric and steric principles governing repression by nuclear hormone receptors.
Genes & development 1997;11(7):835-46.
1997: Schwarz E J; Reginato M J; Shao D; Krakow S L; Lazar M A
Retinoic acid blocks adipogenesis by inhibiting C/EBPbeta-mediated transcription.
Molecular and cellular biology 1997;17(3):1552-61.
1997: Cheng X; Reginato M J; Andrews N C; Lazar M A
The transcriptional integrator CREB-binding protein mediates positive cross talk between nuclear hormone receptors and the hematopoietic bZip protein p45/NF-E2.
Molecular and cellular biology 1997;17(3):1407-16.
1997: Adams M; Reginato M J; Shao D; Lazar M A; Chatterjee V K
Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site.
The Journal of biological chemistry 1997;272(8):5128-32.
1996: Reginato M J; Zhang J; Lazar M A
DNA-independent and DNA-dependent mechanisms regulate the differential heterodimerization of the isoforms of the thyroid hormone receptor with retinoid X receptor.
The Journal of biological chemistry 1996;271(45):28199-205.
1996: Zamir I; Harding H P; Atkins G B; Hörlein A; Glass C K; Rosenfeld M G; Lazar M A
A nuclear hormone receptor corepressor mediates transcriptional silencing by receptors with distinct repression domains.
Molecular and cellular biology 1996;16(10):5458-65.
1996: Kallen C B; Lazar M A
Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):5793-6.
1996: Xue J C; Schwarz E J; Chawla A; Lazar M A
Distinct stages in adipogenesis revealed by retinoid inhibition of differentiation after induction of PPARgamma.
Molecular and cellular biology 1996;16(4):1567-75.
1995: Yu K; Bayona W; Kallen C B; Harding H P; Ravera C P; McMahon G; Brown M; Lazar M A
Differential activation of peroxisome proliferator-activated receptors by eicosanoids.
The Journal of biological chemistry 1995;270(41):23975-83.
1995: Harding H P; Lazar M A
The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat.
Molecular and cellular biology 1995;15(9):4791-802.
1995: Katz D; Reginato M J; Lazar M A
Functional regulation of thyroid hormone receptor variant TR alpha 2 by phosphorylation.
Molecular and cellular biology 1995;15(5):2341-8.
1995: Shulemovich K; Dimaculangan D D; Katz D; Lazar M A
DNA bending by thyroid hormone receptor: influence of half-site spacing and RXR.
Nucleic acids research 1995;23(5):811-8.
1995: Gafvels M E; Paavola L G; Boyd C O; Nolan P M; Wittmaack F; Chawla A; Lazar M A; Bucan M; Angelin B; Strauss J F
Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19".
Endocrinology 1995;136(2):795.
1994: Davis K D; Berrodin T J; Stelmach J E; Winkler J D; Lazar M A
Endogenous retinoid X receptors can function as hormone receptors in pituitary cells.
Molecular and cellular biology 1994;14(11):7105-10.
1994: Dimaculangan D D; Chawla A; Boak A; Kagan H M; Lazar M A
Retinoic acid prevents downregulation of ras recision gene/lysyl oxidase early in adipocyte differentiation.
Differentiation; research in biological diversity 1994;58(1):47-52.
1994: Chawla A; Schwarz E J; Dimaculangan D D; Lazar M A
Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation.
Endocrinology 1994;135(2):798-800.
1994: Dumas B; Harding H P; Choi H S; Lehmann K A; Chung M; Lazar M A; Moore D D
A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb.
Molecular endocrinology (Baltimore, Md.) 1994;8(8):996-1005.
1994: Gåfvels M E; Paavola L G; Boyd C O; Nolan P M; Wittmaack F; Chawla A; Lazar M A; Bucan M; Angelin B O; Strauss J F
Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19.
Endocrinology 1994;135(1):387-94.
1994: Chawla A; Lazar M A
Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1786-90.
1993: Katz D; Lazar M A
Dominant negative activity of an endogenous thyroid hormone receptor variant (alpha 2) is due to competition for binding sites on target genes.
The Journal of biological chemistry 1993;268(28):20904-10.
1993: Chawla A; Lazar M A
Induction of Rev-ErbA alpha, an orphan receptor encoded on the opposite strand of the alpha-thyroid hormone receptor gene, during adipocyte differentiation.
The Journal of biological chemistry 1993;268(22):16265-9.
1993: Lechan R M; Qi Y; Berrodin T J; Davis K D; Schwartz H L; Strait K A; Oppenheimer J H; Lazar M A
Immunocytochemical delineation of thyroid hormone receptor beta 2-like immunoreactivity in the rat central nervous system.
Endocrinology 1993;132(6):2461-9.
1993: Harding H P; Lazar M A
The orphan receptor Rev-ErbA alpha activates transcription via a novel response element.
Molecular and cellular biology 1993;13(5):3113-21.
1993: Davis K D; Lazar M A
Induction of retinoic acid receptor-beta by retinoic acid is cell specific.
Endocrinology 1993;132(4):1469-74.
1993: Lazar M A
Thyroid hormone receptors: multiple forms, multiple possibilities.
Endocrine reviews 1993;14(2):184-93.
1993: Hupart K H; Hodin R A; Lazar M A; Shapiro L E; Chin W W; Surks M I
c-erb-A mRNA correlates with T3-receptor levels in liver and pituitary of tumor rats.
Thyroid : official journal of the American Thyroid Association 1993;3(1):55-8.
1992: Berrodin T J; Marks M S; Ozato K; Linney E; Lazar M A
Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein.
Molecular endocrinology (Baltimore, Md.) 1992;6(9):1468-78.
1992: Katz D; Berrodin T J; Lazar M A
The unique C-termini of the thyroid hormone receptor variant, c-erbA alpha 2, and thyroid hormone receptor alpha 1 mediate different DNA-binding and heterodimerization properties.
Molecular endocrinology (Baltimore, Md.) 1992;6(5):805-14.
1992: Davis K D; Lazar M A
Selective antagonism of thyroid hormone action by retinoic acid.
The Journal of biological chemistry 1992;267(5):3185-9.
1991: Lazar M A
Steroid and thyroid hormone receptors.
Endocrinology and metabolism clinics of North America 1991;20(4):681-95.
1991: Lazar M A; Berrodin T J; Harding H P
Differential DNA binding by monomeric, homodimeric, and potentially heteromeric forms of the thyroid hormone receptor.
Molecular and cellular biology 1991;11(10):5005-15.
1991: Kesavan P; Mukhopadhayay S; Murphy S; Rengaraju M; Lazar M A; Das M
Thyroid hormone decreases the expression of epidermal growth factor receptor.
The Journal of biological chemistry 1991;266(16):10282-6.
1990: Lazar M A; Chin W W
Nuclear thyroid hormone receptors.
The Journal of clinical investigation 1990;86(6):1777-82.
1990: Lazar M A; Berrodin T J
Thyroid hormone receptors form distinct nuclear protein-dependent and independent complexes with a thyroid hormone response element.
Molecular endocrinology (Baltimore, Md.) 1990;4(11):1627-35.
1990: Lazar M A
Sodium butyrate selectively alters thyroid hormone receptor gene expression in GH3 cells.
The Journal of biological chemistry 1990;265(29):17474-7.
1990: Lazar M A; Hodin R A; Cardona G; Chin W W
Gene expression from the c-erbA alpha/Rev-ErbA alpha genomic locus. Potential regulation of alternative splicing by opposite strand transcription.
The Journal of biological chemistry 1990;265(22):12859-63.
1990: Lazar M A; Jones K E; Chin W W
Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone.
DNA and cell biology 1990;9(2):77-83.
1990: Hodin R A; Lazar M A; Chin W W
Differential and tissue-specific regulation of the multiple rat c-erbA messenger RNA species by thyroid hormone.
The Journal of clinical investigation 1990;85(1):101-5.
1989: Lazar M A; Hodin R A; Chin W W
Human carboxyl-terminal variant of alpha-type c-erbA inhibits trans-activation by thyroid hormone receptors without binding thyroid hormone.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7771-4.
1989: Hodin R A; Lazar M A; Chin W W
The pituitary-specific form of rat c-erbA is a biologically active thyroid hormone receptor.
Current surgery 1989;46(4):298-301.
1989: Hodin R A; Lazar M A; Wintman B I; Darling D S; Koenig R J; Larsen P R; Moore D D; Chin W W
Identification of a thyroid hormone receptor that is pituitary-specific.
Science (New York, N.Y.) 1989;244(4900):76-9.
1989: Lazar M A; Hodin R A; Darling D S; Chin W W
A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit.
Molecular and cellular biology 1989;9(3):1128-36.
1989: Koenig R J; Lazar M A; Hodin R A; Brent G A; Larsen P R; Chin W W; Moore D D
Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing.
Nature 1989;337(6208):659-61.
1988: Lazar M A; Hodin R A; Darling D S; Chin W W
Identification of a rat c-erbA alpha-related protein which binds deoxyribonucleic acid but does not bind thyroid hormone.
Molecular endocrinology (Baltimore, Md.) 1988;2(10):893-901.
1988: Lazar M A; Chin W W
Regulation of two c-erbA messenger ribonucleic acids in rat GH3 cells by thyroid hormone.
Molecular endocrinology (Baltimore, Md.) 1988;2(6):479-84.

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