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Sebastian Lazareno

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Jonathan A Hern; Asma H Baig; Gregory I Mashanov; Berry Birdsall; John E T Corrie; Sebastian Lazareno; Justin E Molloy; Nigel J M Birdsall
Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules.
Nigel J M Birdsall; Sebastian Lazareno
Allosterism at muscarinic receptors: ligands and mechanisms.
Sebastian Lazareno
Determination of allosteric interactions using radioligand-binding techniques.

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All Publications

2010: Jonathan A Hern; Asma H Baig; Gregory I Mashanov; Berry Birdsall; John E T Corrie; Sebastian Lazareno; Justin E Molloy; Nigel J M Birdsall
Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(6):2693-8.
2005: Nigel J M Birdsall; Sebastian Lazareno
Allosterism at muscarinic receptors: ligands and mechanisms.
Mini reviews in medicinal chemistry 2005;5(6):523-43.
2004: Sebastian Lazareno
Determination of allosteric interactions using radioligand-binding techniques.
Methods in molecular biology (Clifton, N.J.) 2004;259():29-46.
2004: Sebastian Lazareno; V Dolezal; Angela Popham; Nigel J M Birdsall
Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity.
Molecular pharmacology 2004;65(1):257-66.
2003: Christian Tränkle; Oliver Weyand; Uta Voigtländer; Anita Mynett; Sebastian Lazareno; Nigel J M Birdsall; Klaus Mohr
Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors.
Molecular pharmacology 2003;64(1):180-90.
2003: Sebastian Lazareno; Angela Popham; Nigel J M Birdsall
Progress toward a high-affinity allosteric enhancer at muscarinic M1 receptors.
Journal of molecular neuroscience : MN 2003;20(3):363-7.
2002: Sebastian Lazareno; Angela Popham; Nigel J M Birdsall
Analogs of WIN 62,577 define a second allosteric site on muscarinic receptors.
Molecular pharmacology 2002;62(6):1492-505.
2002: Sebastian Lazareno; Angela Popham; Nigel J M Birdsall
Towards a high-affinity allosteric enhancer at muscarinic M1 receptors.
Journal of molecular neuroscience : MN 2002;19(1-2):123-7.
2002: Parviz Gharagozloo; Sebastian Lazareno; Masao Miyauchi; Angela Popham; Nigel J M Birdsall
Substituted pentacyclic carbazolones as novel muscarinic allosteric agents: synthesis and structure-affinity and cooperativity relationships.
Journal of medicinal chemistry 2002;45(6):1259-74.
2001: Nigel J M Birdsall; Sebastian Lazareno; Angela Popham; José W Saldanha
Multiple allosteric sites on muscarinic receptors.
Life sciences 2001;68(22-23):2517-24.
2000: Sebastian Lazareno; Angela Popham; Nigel J M Birdsall
Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site.
Molecular pharmacology 2000;58(1):194-207.
2000: RA Leppik; Anita Mynett; Sebastian Lazareno; Nigel J M Birdsall
Allosteric interactions between the antagonist prazosin and amiloride analogs at the human alpha(1A)-adrenergic receptor.
Molecular pharmacology 2000;57(3):436-45.
2000: Sebastian Lazareno; Nigel J M Birdsall
Effects of contamination on radioligand binding parameters.
Trends in pharmacological sciences 2000;21(2):57-60.
1999: Nigel J M Birdsall; T Farries; Parviz Gharagozloo; S Kobayashi; Sebastian Lazareno; M Sugimoto
Subtype-selective positive cooperative interactions between brucine analogs and acetylcholine at muscarinic receptors: functional studies.
Molecular pharmacology 1999;55(4):778-86.
1999: Parviz Gharagozloo; Sebastian Lazareno; Angela Popham; Nigel J M Birdsall
Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.
Journal of medicinal chemistry 1999;42(3):438-45.
1999: Sebastian Lazareno; B Birdsall; T Fukazawa; Parviz Gharagozloo; T Hashimoto; H Kuwano; Angela Popham; M Sugimoto; Nigel J M Birdsall
Allosteric effects of four stereoisomers of a fused indole ring system with 3H-N-methylscopolamine and acetylcholine at M1-M4 muscarinic receptors.
Life sciences 1999;64(6-7):519-26.
1998: Sebastian Lazareno; Angela Popham; Nigel J M Birdsall
Muscarinic interactions of bisindolylmaleimide analogues.
European journal of pharmacology 1998;360(2-3):281-4.
1998: RA Leppik; Sebastian Lazareno; Anita Mynett; Nigel J M Birdsall
Characterization of the allosteric interactions between antagonists and amiloride analogues at the human alpha2A-adrenergic receptor.
Molecular pharmacology 1998;53(5):916-25.
1998: Sebastian Lazareno; Parviz Gharagozloo; D Kuonen; Angela Popham; Nigel J M Birdsall
Subtype-selective positive cooperative interactions between brucine analogues and acetylcholine at muscarinic receptors: radioligand binding studies.
Molecular pharmacology 1998;53(3):573-89.
1997: Nigel J M Birdsall; Sebastian Lazareno
To what extent can binding studies allow the quantification of affinity and efficacy?
Annals of the New York Academy of Sciences 1997;812():41-7.
1997: Sebastian Lazareno
Measurement of agonist-stimulated [35S]GTP gamma S binding to cell membranes.
Methods in molecular biology (Clifton, N.J.) 1997;83():107-16.
1997: Nigel J M Birdsall; T Farries; Parviz Gharagozloo; S Kobayashi; D Kuonen; Sebastian Lazareno; Angela Popham; M Sugimoto
Selective allosteric enhancement of the binding and actions of acetylcholine at muscarinic receptor subtypes.
Life sciences 1997;60(13-14):1047-52.
1996: F R Cohen; Sebastian Lazareno; Nigel J M Birdsall
The affinity of adenosine for the high- and low-affinity states of the human adenosine A1 receptor.
European journal of pharmacology 1996;309(1):111-4.
1996: F R Cohen; Sebastian Lazareno; Nigel J M Birdsall
The effects of saponin on the binding and functional properties of the human adenosine A1 receptor.
British journal of pharmacology 1996;117(7):1521-9.
1996: Nigel J M Birdsall; Sebastian Lazareno; H Matsui
Allosteric regulation of muscarinic receptors.
Progress in brain research 1996;109():147-51.
1995: Sebastian Lazareno; Nigel J M Birdsall
Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors.
Molecular pharmacology 1995;48(2):362-78.
1995: Nigel J M Birdsall; F Cohen; Sebastian Lazareno; H Matsui
Allosteric regulation of G-protein-linked receptors.
Biochemical Society transactions 1995;23(1):108-11.
1995: H Matsui; Sebastian Lazareno; Nigel J M Birdsall
Probing of the location of the allosteric site on m1 muscarinic receptors by site-directed mutagenesis.
Molecular pharmacology 1995;47(1):88-98.
1993: Sebastian Lazareno; Nigel J M Birdsall
Pharmacological characterization of acetylcholine-stimulated [35S]-GTP gamma S binding mediated by human muscarinic m1-m4 receptors: antagonist studies.
British journal of pharmacology 1993;109(4):1120-7.
1993: Sebastian Lazareno; Nigel J M Birdsall
Estimation of competitive antagonist affinity from functional inhibition curves using the Gaddum, Schild and Cheng-Prusoff equations.
British journal of pharmacology 1993;109(4):1110-9.
1993: Sebastian Lazareno; Nigel J M Birdsall
Estimation of antagonist Kb from inhibition curves in functional experiments: alternatives to the Cheng-Prusoff equation.
Trends in pharmacological sciences 1993;14(6):237-9.
1993: Sebastian Lazareno; T Farries; Nigel J M Birdsall
Pharmacological characterization of guanine nucleotide exchange reactions in membranes from CHO cells stably transfected with human muscarinic receptors m1-m4.
Life sciences 1993;52(5-6):449-56.