FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Lawrence Lazarus

Research Profile

Chemicals & Drugs

Concepts & Ideas

Structure-Activity Relationship

Living Beings

Anatomy

Co-author Network

Publications

TOP 3
Gianfranco Balboni; Severo Salvadori; Ewa D Marczak; Brian I Knapp; Jean M Bidlack; Lawrence H Lazarus; Xuemei Peng; Yu Gui Si; John L Neumeyer
Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic.
Gianfranco Balboni; Erika Marzola; Yusuke Sasaki; Akihiro Ambo; Ewa D Marczak; Lawrence H Lazarus; Severo Salvadori
Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds.
Steven Ballet; Ewa D Marczak; Debby Feytens; Severo Salvadori; Yusuke Sasaki; Andrew D Abell; Lawrence H Lazarus; Gianfranco Balboni; Dirk Tourwé
Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Lawrence Lazarus (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2011: Gianfranco Balboni; Severo Salvadori; Ewa D Marczak; Brian I Knapp; Jean M Bidlack; Lawrence H Lazarus; Xuemei Peng; Yu Gui Si; John L Neumeyer
Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic.
European journal of medicinal chemistry 2011;46(2):799-803.
2010: Gianfranco Balboni; Erika Marzola; Yusuke Sasaki; Akihiro Ambo; Ewa D Marczak; Lawrence H Lazarus; Severo Salvadori
Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds.
Bioorganic & medicinal chemistry 2010;18(16):6024-30.
2010: Steven Ballet; Ewa D Marczak; Debby Feytens; Severo Salvadori; Yusuke Sasaki; Andrew D Abell; Lawrence H Lazarus; Gianfranco Balboni; Dirk Tourwé
Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.
Bioorganic & medicinal chemistry letters 2010;20(5):1610-3.
2009: Yuan Feng; Dongman Chao; Xiaozhou He; Yilin Yang; Xuezhi Kang; Lawrence H Lazarus; Ying Xia
A novel insight into neuroprotection against hypoxic/ischemic stress.
Sheng li xue bao : [Acta physiologica Sinica] 2009;61(6):585-92.
2009: Gianfranco Balboni; Claudio Trapella; Yusuke Sasaki; Akihiro Ambo; Ewa D Marczak; Lawrence H Lazarus; Severo Salvadori
Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore.
Journal of medicinal chemistry 2009;52(17):5556-9.
2009: Ewa D Marczak; Yunden Jinsmaa; Page H Myers; Terry Blankenship; Ralph Wilson; Gianfranco Balboni; Severo Salvadori; Lawrence H Lazarus
Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent mu/delta-opioid receptor antagonist, regulates obese-related factors in mice.
European journal of pharmacology 2009;616(1-3):115-21.
2009: Steven Ballet; Debby Feytens; Rien De Wachter; Magali De Vlaeminck; Ewa D Marczak; Severo Salvadori; Chris de Graaf; Didier Rognan; Lucia Negri; Roberta Lattanzi; Lawrence H Lazarus; Dirk Tourwé; Gianfranco Balboni
Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold.
Bioorganic & medicinal chemistry letters 2009;19(2):433-7.
2008: Yunden Jinsmaa; Ewa D Marczak; Gianfranco Balboni; Severo Salvadori; Lawrence H Lazarus
Inhibition of the development of morphine tolerance by a potent dual mu-delta-opioid antagonist, H-Dmt-Tic-Lys-NH-CH2-Ph.
Pharmacology, biochemistry, and behavior 2008;90(4):651-7.
2008: Gianfranco Balboni; Stella Fiorini; Anna Baldisserotto; Claudio Trapella; Yusuke Sasaki; Akihiro Ambo; Ewa D Marczak; Lawrence H Lazarus; Severo Salvadori
Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic.
Journal of medicinal chemistry 2008;51(16):5109-17.
2008: Severo Salvadori; Stella Fiorini; Claudio Trapella; Frank Porreca; Peg Davis; Yusuke Sasaki; Akihiro Ambo; Ewa D Marczak; Lawrence H Lazarus; Gianfranco Balboni
Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502).
Bioorganic & medicinal chemistry 2008;16(6):3032-8.
2008: Raffaella Vergura; Gianfranco Balboni; Barbara Spagnolo; Elaine Gavioli; David G Lambert; John McDonald; Claudio Trapella; Lawrence H Lazarus; Domenico Regoli; Remo Guerrini; Severo Salvadori; Girolamo Caló
Anxiolytic- and antidepressant-like activities of H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), a novel selective delta opioid receptor agonist.
Peptides 2008;29(1):93-103.
2007: Severo Salvadori; Claudio Trapella; Stella Fiorini; Lucia Negri; Roberta Lattanzi; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus; Gianfranco Balboni
A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic.
Bioorganic & medicinal chemistry 2007;15(22):6876-81.
2007: Kimitaka Shiotani; Anna Miyazaki; Tingyou Li; Yuko Tsuda; Toshio Yokoi; Akihiro Ambo; Yusuke Sasaki; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus; Yoshio Okada
Synthesis of opioidmimetics, 3-[H-Dmt-NH(CH(2))(m)]-6-[H-Dmt-NH(CH(2))(n)]-2(1H)-pyrazinones, and studies on structure-activity relationships.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2007;3(6):583-98.
2007: Kimitaka Shiotani; Tingyou Li; Anna Miyazaki; Yuko Tsuda; Toshio Yokoi; Akihiro Ambo; Yusuke Sasaki; Sharon D Bryant; Lawrence H Lazarus; Yoshio Okada
Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform.
Bioorganic & medicinal chemistry letters 2007;17(21):5768-71.
2007: Ewa Marczak; Yunden Jinsmaa; Tingyou Li; Sharon D Bryant; Yuko Tsuda; Yoshio Okada; Lawrence H Lazarus
[N-allyl-Dmt1]-endomorphins are micro-opioid receptor antagonists lacking inverse agonist properties.
The Journal of pharmacology and experimental therapeutics 2007;323(1):374-80.
2007: Tingyou Li; Kimitaka Shiotani; Anna Miyazaki; Yuko Tsuda; Akihiro Ambo; Yusuke Sasaki; Yunden Jinsmaa; Ewa Marczak; Sharon D Bryant; Lawrence H Lazarus; Yoshio Okada
Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.
Journal of medicinal chemistry 2007;50(12):2753-66.
2007: Gianfranco Balboni; Valentina Onnis; Cenzo Congiu; Margherita Zotti; Yusuke Sasaki; Akihiro Ambo; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus; Ilaria Lazzari; Claudio Trapella; Severo Salvadori
Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore.
Bioorganic & medicinal chemistry 2007;15(9):3143-51.
2007: Tingyou Li; Yunden Jinsmaa; Masahiro Nedachi; Anna Miyazaki; Yuko Tsuda; Akihiro Ambo; Yusuke Sasaki; Sharon D Bryant; Ewa Marczak; Qiang Li; H Scott Swartzwelder; Lawrence H Lazarus; Yoshio Okada
Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists.
Bioorganic & medicinal chemistry 2007;15(3):1237-51.
2006: Kimitaka Shiotani; Tingyou Li; Anna Miyazaki; Yuko Tsuda; Sharon D Bryant; Akihiro Ambo; Yusuke Sasaki; Lawrence H Lazarus; Yoshio Okada
Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity.
Bioorganic & medicinal chemistry letters 2006;16(22):5793-6.
2006: John L Neumeyer; Xuemei Peng; Brian I Knapp; Jean M Bidlack; Lawrence H Lazarus; Severo Salvadori; Claudio Trapella; Gianfranco Balboni
New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.
Journal of medicinal chemistry 2006;49(18):5640-3.
2006: Gianfranco Balboni; Valentina Onnis; Cenzo Congiu; Margherita Zotti; Yusuke Sasaki; Akihiro Ambo; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus; Claudio Trapella; Severo Salvadori
Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.
Journal of medicinal chemistry 2006;49(18):5610-7.
2006: Steven Ballet; Severo Salvadori; Claudio Trapella; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus; Lucia Negri; Elisa Giannini; Roberta Lattanzi; Dirk Tourwé; Gianfranco Balboni
New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands.
Journal of medicinal chemistry 2006;49(13):3990-3.
2006: M. Eugenio Vázquez; Juan B Blanco; Severo Salvadori; Claudio Trapella; Roberto Argazzi; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus; Lucia Negri; Elisa Giannini; Roberta Lattanzi; Mariantonella Colucci; Gianfranco Balboni
6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.
Journal of medicinal chemistry 2006;49(12):3653-8.
2006: Yunden Jinsmaa; Ewa Marczak; Yoshio Fujita; Kimitaka Shiotani; Anna Miyazaki; Tingyou Li; Yuko Tsuda; Akihiro Ambo; Yusuke Sasaki; Sharon D Bryant; Yoshio Okada; Lawrence H Lazarus
Potent in vivo antinociception and opioid receptor preference of the novel analogue [Dmt1]endomorphin-1.
Pharmacology, biochemistry, and behavior 2006;84(2):252-8.
2006: Tingyou Li; Yuko Tsuda; Katsuhiko Minoura; Yasuko In; Toshimasa Ishida; Lawrence H Lazarus; Yoshio Okada
Enantioselective synthesis of a phenylalanine library containing alkyl groups on the aromatic moiety: confirmation of stereostructure by X-ray analysis.
Chemical & pharmaceutical bulletin 2006;54(6):873-7.
2005: Gianfranco Balboni; Remo Guerrini; Severo Salvadori; Lucia Negri; Elisa Giannini; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus
Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).
Journal of medicinal chemistry 2005;48(26):8112-4.
2005: Tingyou Li; Yoshio Fujita; Kimitaka Shiotani; Anna Miyazaki; Yuko Tsuda; Akihiro Ambo; Yusuke Sasaki; Yunden Jinsmaa; Ewa Marczak; Sharon D Bryant; Severo Salvadori; Lawrence H Lazarus; Yoshio Okada
Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists.
Journal of medicinal chemistry 2005;48(25):8035-44.
2005: Tingyou Li; Kimitaka Shiotani; Anna Miyazaki; Yoshio Fujita; Yuko Tsuda; Akihiro Ambo; Yusuke Sasaki; Yunden Jinsmaa; Ewa Marczak; Sharon D Bryant; Lawrence H Lazarus; Yoshio Okada
New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif.
Bioorganic & medicinal chemistry letters 2005;15(24):5517-20.
2005: Yasuko In; Katsuhiko Minoura; Koji Tomoo; Yusuke Sasaki; Lawrence H Lazarus; Yoshio Okada; Toshimasa Ishida
Structural function of C-terminal amidation of endomorphin. Conformational comparison of mu-selective endomorphin-2 with its C-terminal free acid, studied by 1H-NMR spectroscopy, molecular calculation, and X-ray crystallography.
The FEBS journal 2005;272(19):5079-97.
2005: Anna Miyazaki; Yutaka Fujisawa; Kimitaka Shiotani; Yoshio Fujita; Tingyou Li; Yuko Tsuda; Toshio Yokoi; Sharon D Bryant; Lawrence H Lazarus; Yoshio Okada
Studies on the mechanism of 1,2-dihydropyrazin-2-one ring formation from dipeptidyl chloromethyl ketone and its chemical properties: immediate deamination during catalytic hydrogenation.
Chemical & pharmaceutical bulletin 2005;53(9):1152-8.
2005: Gianfranco Balboni; Maria Teresa Cocco; Severo Salvadori; Romeo Romagnoli; Yusuke Sasaki; Yoshio Okada; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus
From the potent and selective mu opioid receptor agonist H-Dmt-d-Arg-Phe-Lys-NH(2) to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH.
Journal of medicinal chemistry 2005;48(17):5608-11.
2005: Petra Tryoen-Tóth; Fabien M Décaillot; Dominique Filliol; Katia Befort; Lawrence H Lazarus; P W Schiller; H Schmidhammer; Jerome Becker
Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors.
The Journal of pharmacology and experimental therapeutics 2005;313(1):410-21.
2005: Yunden Jinsmaa; Yoshio Fujita; Kimitaka Shiotani; Anna Miyazaki; Tingyou Li; Yuko Tsuda; Yoshio Okada; Akihiro Ambo; Yusuke Sasaki; Sharon D Bryant; Lawrence H Lazarus
Differentiation of opioid receptor preference by [Dmt1]endomorphin-2-mediated antinociception in the mouse.
European journal of pharmacology 2005;509(1):37-42.
2005: Yoshio Fujita; Yuko Tsuda; Takashi Motoyama; Tingyou Li; Anna Miyazaki; Toshio Yokoi; Yusuke Sasaki; Akihiro Ambo; Hideko Niizuma; Yunden Jinsmaa; Sharon D Bryant; Lawrence H Lazarus; Yoshio Okada
Studies on the structure-activity relationship of 2',6'-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH(3).
Bioorganic & medicinal chemistry letters 2005;15(3):599-602.
2005: Tingyou Li; Yoshio Fujita; Yuko Tsuda; Anna Miyazaki; Akihiro Ambo; Yusuke Sasaki; Yunden Jinsmaa; Sharon D Bryant; Lawrence H Lazarus; Yoshio Okada
Development of potent mu-opioid receptor ligands using unique tyrosine analogues of endomorphin-2.
Journal of medicinal chemistry 2005;48(2):586-92.
2004: Gianfranco Balboni; Severo Salvadori; Alessandro Dal Piaz; Fabrizio Bortolotti; Roberto Argazzi; Lucia Negri; Roberta Lattanzi; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus
Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic.
Journal of medicinal chemistry 2004;47(26):6541-6.
2004: Gianfranco Balboni; Severo Salvadori; Remo Guerrini; Lucia Negri; Elisa Giannini; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus
Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism.
Journal of medicinal chemistry 2004;47(16):4066-71.
2004: Yoshio Fujita; Yuko Tsuda; Tingyou Li; Takashi Motoyama; Motohiro Takahashi; Yoshiro Shimizu; Toshio Yokoi; Yusuke Sasaki; Akihiro Ambo; Atsuko Kita; Yunden Jinsmaa; Sharon D Bryant; Lawrence H Lazarus; Yoshio Okada
Development of potent bifunctional endomorphin-2 analogues with mixed mu-/delta-opioid agonist and delta-opioid antagonist properties.
Journal of medicinal chemistry 2004;47(14):3591-9.
2004: Yunden Jinsmaa; Anna Miyazaki; Yoshio Fujita; Tingyou Li; Yutaka Fujisawa; Kimitaka Shiotani; Yuko Tsuda; Toshio Yokoi; Akihiro Ambo; Yusuke Sasaki; Sharon D Bryant; Lawrence H Lazarus; Yoshio Okada
Oral bioavailability of a new class of micro-opioid receptor agonists containing 3,6-bis[Dmt-NH(CH(2))(n)]-2(1H)-pyrazinone with central-mediated analgesia.
Journal of medicinal chemistry 2004;47(10):2599-610.
2004: Yunden Jinsmaa; Yoshio Okada; Yuko Tsuda; Kimitaka Shiotani; Yusuke Sasaki; Akihiro Ambo; Sharon D Bryant; Lawrence H Lazarus
Novel 2',6'-dimethyl-L-tyrosine-containing pyrazinone opioid mimetic mu-agonists with potent antinociceptive activity in mice.
The Journal of pharmacology and experimental therapeutics 2004;309(1):432-8.
2003: Gianfranco Balboni; Severo Salvadori; Remo Guerrini; Lucia Negri; Elisa Giannini; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus
Synthesis and opioid activity of N,N-dimethyl-Dmt-Tic-NH-CH(R)-R' analogues: acquisition of potent delta antagonism.
Bioorganic & medicinal chemistry 2003;11(24):5435-41.
2003: Yoshio Okada; Yuko Tsuda; Yoshio Fujita; Toshio Yokoi; Yusuke Sasaki; Akihiro Ambo; Ryoji Konishi; Mitsuhiro Nagata; Severo Salvadori; Yunden Jinsmaa; Sharon D Bryant; Lawrence H Lazarus
Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia.
Journal of medicinal chemistry 2003;46(15):3201-9.
2003: Yoshio Okada; Yoshio Fujita; Takashi Motoyama; Yuko Tsuda; Toshio Yokoi; Tingyou Li; Yusuke Sasaki; Akihiro Ambo; Yunden Jinsmaa; Sharon D Bryant; Lawrence H Lazarus
Structural studies of [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues: enhanced activity and cis orientation of the Dmt-Pro amide bond.
Bioorganic & medicinal chemistry 2003;11(9):1983-94.
2003: Sharon D Bryant; Yunden Jinsmaa; Severo Salvadori; Yoshio Okada; Lawrence H Lazarus
Dmt and opioid peptides: a potent alliance.
Biopolymers 2003;71(2):86-102.
2002: Gianfranco Balboni; Severo Salvadori; Remo Guerrini; Lucia Negri; Elisa Giannini; Yunden Jinsmaa; Sharon D Bryant; Lawrence H Lazarus
Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.
Journal of medicinal chemistry 2002;45(25):5556-63.
2002: Sharon D Bryant; Clifford George; Judith L Flippen-Anderson; Jeffrey Deschamps; Severo Salvadori; Gianfranco Balboni; Remo Guerrini; Lawrence H Lazarus
Crystal structures of dipeptides containing the Dmt-Tic pharmacophore.
Journal of medicinal chemistry 2002;45(25):5506-13.
2002: Gianfranco Balboni; Remo Guerrini; Severo Salvadori; Clementina Bianchi; Daniela Rizzi; Sharon D Bryant; Lawrence H Lazarus
Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.
Journal of medicinal chemistry 2002;45(3):713-20.
2002: Yoshio Okada; Yuko Tsuda; Sharon D Bryant; Lawrence H Lazarus
Endomorphins and related opioid peptides.
Vitamins and hormones 2002;65():257-79.
2001: T Lovekamp; PS Cooper; J Hardison; Sharon D Bryant; Remo Guerrini; Gianfranco Balboni; Severo Salvadori; Lawrence H Lazarus
Inhibition of human multidrug resistance P-glycoprotein 1 by analogues of a potent delta-opioid antagonist.
Brain research 2001;902(1):131-4.
2000: Vincenzo Santagada; Gianfranco Balboni; Giuseppe Caliendo; Remo Guerrini; Severo Salvadori; C Bianchi; Sharon D Bryant; Lawrence H Lazarus
Assessment of substitution in the second pharmacophore of Dmt-Tic analogues.
Bioorganic & medicinal chemistry letters 2000;10(24):2745-8.
2000: Gianfranco Balboni; Severo Salvadori; Remo Guerrini; C Bianchi; Vincenzo Santagada; G Calliendo; Sharon D Bryant; Lawrence H Lazarus
Opioid pseudopeptides containing heteroaromatic or heteroaliphatic nuclei.
Peptides 2000;21(11):1663-71.
2000: Maryse Labarre; J Butterworth; Stéphane St-Onge; Kemal Payza; H Schmidhammer; S Salvadori; Gianfranco Balboni; R Guerrini; Sharon D Bryant; Lawrence H Lazarus
Inverse agonism by Dmt-Tic analogues and HS 378, a naltrindole analogue.
European journal of pharmacology 2000;406(1):R1-3.
2000: Yoshio Okada; A Fukumizu; M Takahashi; Y Shimizu; Yuko Tsuda; Toshio Yokoi; Sharon D Bryant; Lawrence H Lazarus
Synthesis of stereoisomeric analogues of endomorphin-2, H-Tyr-Pro-Phe-Phe-NH(2), and examination of their opioid receptor binding activities and solution conformation.
Biochemical and biophysical research communications 2000;276(1):7-11.
2000: Krisztina Monory; Sharon D Bryant; István Kertész; Gianfranco Balboni; R Guerrini; G Tóth; S Salvadori; Lawrence H Lazarus; Anna Borsodi
Characterization of N,N(Me)2-Dmt-Tic-OH, a delta selective opioid dipeptide antagonist.
Neuroreport 2000;11(10):2083-6.
1999: Severo Salvadori; Remo Guerrini; Gianfranco Balboni; Clementina Bianchi; Sharon D Bryant; PS Cooper; Lawrence H Lazarus
Further studies on the Dmt-Tic pharmacophore: hydrophobic substituents at the C-terminus endow delta antagonists to manifest mu agonism or mu antagonism.
Journal of medicinal chemistry 1999;42(24):5010-9.
1999: Yoshio Okada; A Fukumizu; M Takahashi; Toshio Yokoi; Yuko Tsuda; Sharon D Bryant; Lawrence H Lazarus
Synthesis of pyrazinone ring-containing opioid mimetics and examination of their opioid receptor-binding activity.
Chemical & pharmaceutical bulletin 1999;47(8):1193-5.
1999: Lawrence H Lazarus; Sharon D Bryant; PS Cooper; Severo Salvadori
What peptides these deltorphins be.
Progress in neurobiology 1999;57(4):377-420.
1999: Mauro Marastoni; Remo Guerrini; Gianfranco Balboni; Severo Salvadori; Giancarlo Fantin; Marco Fogagnolo; Lawrence H Lazarus; Roberto Tomatis
Opioid deltorphin C analogues containing cis- or trans-2- or 3- or 4-aminocyclohexanecarboxylic acid residues.
Arzneimittel-Forschung 1999;49(1):6-12.
1998: Yoshio Okada; M Tsukatani; H Taguchi; Toshio Yokoi; Sharon D Bryant; Lawrence H Lazarus
Amino acids and peptides. LII. Design and synthesis of opioid mimetics containing a pyrazinone ring and examination of their opioid receptor binding activity.
Chemical & pharmaceutical bulletin 1998;46(9):1374-82.
1998: Sharon D Bryant; Severo Salvadori; PS Cooper; Lawrence H Lazarus
New delta-opioid antagonists as pharmacological probes.
Trends in pharmacological sciences 1998;19(2):42-6.
1998: Remo Guerrini; Anna Capasso; Mauro Marastoni; Sharon D Bryant; PS Cooper; Lawrence H Lazarus; Piero A Temussi; Severo Salvadori
Rational design of dynorphin A analogues with delta-receptor selectivity and antagonism for delta- and kappa-receptors.
Bioorganic & medicinal chemistry 1998;6(1):57-62.
1997: Anna Capasso; Pietro Amodeo; Gianfranco Balboni; Remo Guerrini; Lawrence H Lazarus; Piero A Temussi; Severo Salvadori
Design of mu selective opioid dipeptide antagonists.
FEBS letters 1997;417(1):141-4.
1997: Severo Salvadori; Gianfranco Balboni; Remo Guerrini; Roberto Tomatis; Clementina Bianchi; Sharon D Bryant; PS Cooper; Lawrence H Lazarus
Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.
Journal of medicinal chemistry 1997;40(19):3100-8.
1997: Roberto Tomatis; Mauro Marastoni; Gianfranco Balboni; Remo Guerrini; Anna Capasso; Ludovico Sorrentino; Vincenzo Santagada; G Caliendo; Lawrence H Lazarus; Severo Salvadori
Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides.
Journal of medicinal chemistry 1997;40(18):2948-52.
1997: Sharon D Bryant; Remo Guerrini; Severo Salvadori; C Bianchi; Roberto Tomatis; M Attila; Lawrence H Lazarus
Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues.
Journal of medicinal chemistry 1997;40(16):2579-87.
1997: Orlando Crescenzi; Franca Fraternali; Delia Picone; Teodorico Tancredi; Gianfranco Balboni; Remo Guerrini; Lawrence H Lazarus; Severo Salvadori; Piero A Temussi
Design and solution structure of a partially rigid opioid antagonist lacking the basic center--models of antagonism.
European journal of biochemistry / FEBS 1997;247(1):66-73.
1997: Remo Guerrini; Girolamo Calo; Anna Rizzi; Clementina Bianchi; Lawrence H Lazarus; Severo Salvadori; Piero A Temussi; Domenico Regoli
Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin-(1-13)-peptide amide.
Journal of medicinal chemistry 1997;40(12):1789-93.
1997: Severo Salvadori; Delia Picone; Teodorico Tancredi; Remo Guerrini; Roberta Spadaccini; Lawrence H Lazarus; D Regoli; Piero A Temussi
Solution conformation of nociceptin.
Biochemical and biophysical research communications 1997;233(3):640-3.
1997: Sharon D Bryant; Gianfranco Balboni; Remo Guerrini; Severo Salvadori; Roberto Tomatis; Lawrence H Lazarus
Opioid diketopiperazines: refinement of the delta opioid antagonist pharmacophore.
Biological chemistry 1997;378(2):107-14.
1997: Gianfranco Balboni; Remo Guerrini; Severo Salvadori; Roberto Tomatis; Sharon D Bryant; Clementina Bianchi; M Attila; Lawrence H Lazarus
Opioid diketopiperazines: synthesis and activity of a prototypic class of opioid antagonists.
Biological chemistry 1997;378(1):19-29.
1996: Remo Guerrini; A Capasso; Ludovico Sorrentino; R Anacardio; Sharon D Bryant; Lawrence H Lazarus; M Attila; Severo Salvadori
Opioid receptor selectivity alteration by single residue replacement: synthesis and activity profile of [Dmt1]deltorphin B.
European journal of pharmacology 1996;302(1-3):37-42.
1996: A Breveglieri; Remo Guerrini; Severo Salvadori; Clementina Bianchi; Sharon D Bryant; M Attila; Lawrence H Lazarus
Design and synthesis of 1-aminocycloalkane-1-carboxylic acid-substituted deltorphin analogues: unique delta and mu opioid activity in modified peptides.
Journal of medicinal chemistry 1996;39(3):773-80.
1996: Lawrence H Lazarus; Sharon D Bryant; Severo Salvadori; M Attila; L Sargent Jones
Opioid infidelity: novel opioid peptides with dual high affinity for delta- and mu-receptors.
Trends in neurosciences 1996;19(1):31-5.
1996: A Capasso; Remo Guerrini; Gianfranco Balboni; Ludovico Sorrentino; Piero A Temussi; Lawrence H Lazarus; Sharon D Bryant; Severo Salvadori
Dmt-Tic-OH a highly selective and potent delta-opioid dipeptide receptor antagonist after systemic administration in the mouse.
Life sciences 1996;59(8):PL93-8.
1995: Gianfranco Balboni; Severo Salvadori; F D'Angeli; P Marchetti; Lawrence H Lazarus; Sharon D Bryant; Clementina Bianchi
Single diastereomeric desaminotyrosylalanyl tetra- and heptapeptides with opioid antagonistic activity.
International journal of peptide and protein research 1995;45(2):187-93.
1994: Teodorico Tancredi; Severo Salvadori; Pietro Amodeo; Delia Picone; Lawrence H Lazarus; Sharon D Bryant; Remo Guerrini; G Marzola; Piero A Temussi
Conversion of enkephalin and dermorphin into delta-selective opioid antagonists by single-residue substitution.
European journal of biochemistry / FEBS 1994;224(1):241-7.
1994: Lawrence H Lazarus; Sharon D Bryant; M Attila; Severo Salvadori
Frog skin opioid peptides: a case for environmental mimicry.
Environmental health perspectives 1994;102(8):648-54.
1994: Sharon D Bryant; M Attila; Severo Salvadori; Remo Guerrini; Lawrence H Lazarus
Molecular dynamics conformations of deltorphin analogues advocate delta opioid binding site models.
Peptide research 1994;7(4):175-84.
1994: Piero A Temussi; Severo Salvadori; Pietro Amodeo; C Bianchi; Remo Guerrini; Roberto Tomatis; Lawrence H Lazarus; Delia Picone; Teodorico Tancredi
Selective opioid dipeptides.
Biochemical and biophysical research communications 1994;198(3):933-9.
1993: M Attila; Severo Salvadori; Gianfranco Balboni; Sharon D Bryant; Lawrence H Lazarus
Synthesis and receptor binding analysis of dermorphin hepta-, hexa- and pentapeptide analogues. Evidence for one- and two-side binding models for the mu-opioid receptor.
International journal of peptide and protein research 1993;42(6):550-9.
1993: Severo Salvadori; Sharon D Bryant; Clementina Bianchi; Gianfranco Balboni; V Scaranari; M Attila; Lawrence H Lazarus
Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors.
Journal of medicinal chemistry 1993;36(24):3748-56.
1993: Lawrence H Lazarus; M Attila
The toad, ugly and venomous, wears yet a precious jewel in his skin.
Progress in neurobiology 1993;41(4):473-507.
1993: Severo Salvadori; Sharon D Bryant; Piero A Temussi; D M Bundy; M Attila; Roberto Tomatis; Lawrence H Lazarus
Relationship between receptor affinity and topography of N-terminally extended and bridged [Tyr1-->Asp4]deltorphin C analogues: novel probes for the delta-opioid receptor.
European journal of pharmacology 1993;230(3):357-61.
1993: Lawrence H Lazarus; Severo Salvadori; M Attila; P Grieco; D M Bundy; W E Wilson; Roberto Tomatis
Interaction of deltorphin with opioid receptors: molecular determinants for affinity and selectivity.
Peptides 1993;14(1):21-8.
1992: Severo Salvadori; Clementina Bianchi; Lawrence H Lazarus; V Scaranari; M Attila; Roberto Tomatis
Para-substituted Phe3 deltorphin analogues: enhanced selectivity of halogenated derivatives for delta opioid receptor sites.
Journal of medicinal chemistry 1992;35(25):4651-7.
1992: Lawrence H Lazarus; Severo Salvadori; Gianfranco Balboni; Roberto Tomatis; W E Wilson
Stereospecificity of amino acid side chains in deltorphin defines binding to opioid receptors.
Journal of medicinal chemistry 1992;35(7):1222-7.
1991: Mauro Marastoni; Roberto Tomatis; Gianfranco Balboni; Severo Salvadori; Lawrence H Lazarus
On the degradation of the deltorphin peptides by plasma and brain homogenate.
Farmaco (Società chimica italiana : 1989) 1991;46(11):1273-9.
1991: Lawrence H Lazarus; Severo Salvadori; Roberto Tomatis; W E Wilson
Opioid receptor selectivity reversal in deltorphin tetrapeptide analogues.
Biochemical and biophysical research communications 1991;178(1):110-5.
1991: Lawrence H Lazarus; Severo Salvadori; Vincenzo Santagada; Roberto Tomatis; W E Wilson
Function of negative charge in the "address domain" of deltorphins.
Journal of medicinal chemistry 1991;34(4):1350-5.
1990: Lawrence H Lazarus; W E Wilson; A Guglietta; R de Castiglione
Dermorphin interaction with rat brain opioid receptors: involvement of hydrophobic sites in the binding domain.
Molecular pharmacology 1990;37(6):886-92.
1989: A Guglietta; B J Irons; Lawrence H Lazarus; R de Castiglione; Pietro Melchiorri
Dimeric dermorphin peptides: central administration suppresses gastric acid secretion through interaction with mu-type opioid receptor.
Methods and findings in experimental and clinical pharmacology 1989;11(11):663-70.
1989: W E Wilson; Lawrence H Lazarus; Kenneth B Tomer
Bradykinin and kininogens in bovine milk.
The Journal of biological chemistry 1989;264(30):17777-83.
1989: A Guglietta; R V Nardi; Lawrence H Lazarus
Indomethacin (i.c.v.) reverses the inhibitory action of peptides on gastric secretion.
European journal of pharmacology 1989;170(1-2):87-90.
1989: Lawrence H Lazarus; W E Wilson; R de Castiglione; A Guglietta
Dermorphin gene sequence peptide with high affinity and selectivity for delta-opioid receptors.
The Journal of biological chemistry 1989;264(6):3047-50.
1989: Lawrence H Lazarus; A Guglietta; W E Wilson; B J Irons; R de Castiglione
Dimeric dermorphin analogues as mu-receptor probes on rat brain membranes. Correlation between central mu-receptor potency and suppression of gastric acid secretion.
The Journal of biological chemistry 1989;264(1):354-62.
1989: Tindaro G Renda; L D'Este; A Fasolo; Lawrence H Lazarus; F Minniti; Vittorio Erspamer
Brain-gut-skin peptides: an update overview.
Archives of histology and cytology 1989;52 Suppl():317-23.
1988: A Guglietta; B J Irons; Lawrence H Lazarus; S P Sivam
Effects and mechanism of action of lithium chloride on gastric acid secretion in rats.
Gastroenterology 1988;95(6):1454-9.
1988: A Guglietta; B J Irons; Lawrence H Lazarus
Effect of bombesin, dermorphin and salmon calcitonin on gastric acid secretion in rats.
Methods and findings in experimental and clinical pharmacology 1988;10(8):481-5.
1988: Lawrence H Lazarus; B J Irons; L M Grimes; W E Wilson; A Guglietta; H Yajima
Assessment of neuromedin B polyclonal antibodies as molecular probes in neural tissue.
Journal of neuroscience methods 1988;23(2):161-72.
1988: Lawrence H Lazarus; A Guglietta; W E Wilson; L M Grimes; B J Irons; H Yajima
Neuromedin B: physiological and pharmacological perturbations.
Annals of the New York Academy of Sciences 1988;547():404-14.
1987: A Guglietta; B J Irons; Lawrence H Lazarus; Pietro Melchiorri
Structure-activity relationship of dermorphin on gastric secretion.
Endocrinology 1987;120(5):2137-43.
1986: Lawrence H Lazarus; Giovanni Gaudino; W E Wilson; V Erspamer
An immunoreactive peptide in milk contains bombesin-like bioactivity.
Experientia 1986;42(7):822-3.
1985: Giovanni Gaudino; A Fasolo; G Merlo; Lawrence H Lazarus; Tindaro G Renda; L D'Este; Frans Vandesand
Active peptides from amphibian skin are also amphibian neuropeptides.
Peptides 1985;6 Suppl 3():209-13.
1985: A Guglietta; C L Strunk; B J Irons; Lawrence H Lazarus
Central neuromodulation of gastric acid secretion by bombesin-like peptides.
Peptides 1985;6 Suppl 3():75-81.
1985: Lawrence H Lazarus; W E Wilson; Giovanni Gaudino; B J Irons; A Guglietta
Evolutionary relationship between nonmammalian and mammalian peptides.
Peptides 1985;6 Suppl 3():295-307.