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Lawrence Lazarus

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Balboni Gianfranco; Trapella Claudio; Sasaki Yusuke; Ambo Akihiro; Marczak Ewa D; Lazarus Lawrence H; Salvadori Severo
Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore.
Marczak Ewa D; Jinsmaa Yunden; Myers Page H; Blankenship Terry; Wilson Ralph; Balboni Gianfranco; Salvadori Severo; Lazarus Lawrence H
Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent mu/delta-opioid receptor antagonist, regulates obese-related factors in mice.
Ballet Steven; Feytens Debby; Wachter Rien De; Vlaeminck Magali De; Marczak Ewa D; Salvadori Severo; Graaf Chris de; Rognan Didier; Negri Lucia; Lattanzi Roberta; Lazarus Lawrence H; Tourwé Dirk; Balboni Gianfranco
Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold.

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All Publications

2009: Balboni Gianfranco; Trapella Claudio; Sasaki Yusuke; Ambo Akihiro; Marczak Ewa D; Lazarus Lawrence H; Salvadori Severo
Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore.
Journal of medicinal chemistry 2009;52(17):5556-9.
2009: Marczak Ewa D; Jinsmaa Yunden; Myers Page H; Blankenship Terry; Wilson Ralph; Balboni Gianfranco; Salvadori Severo; Lazarus Lawrence H
Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent mu/delta-opioid receptor antagonist, regulates obese-related factors in mice.
European journal of pharmacology 2009;616(1-3):115-21.
2009: Ballet Steven; Feytens Debby; Wachter Rien De; Vlaeminck Magali De; Marczak Ewa D; Salvadori Severo; Graaf Chris de; Rognan Didier; Negri Lucia; Lattanzi Roberta; Lazarus Lawrence H; Tourwé Dirk; Balboni Gianfranco
Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold.
Bioorganic & medicinal chemistry letters 2009;19(2):433-7.
2008: Jinsmaa Yunden; Marczak Ewa D; Balboni Gianfranco; Salvadori Severo; Lazarus Lawrence H
Inhibition of the development of morphine tolerance by a potent dual mu-delta-opioid antagonist, H-Dmt-Tic-Lys-NH-CH2-Ph.
Pharmacology, biochemistry, and behavior 2008;90(4):651-7.
2008: Balboni Gianfranco; Fiorini Stella; Baldisserotto Anna; Trapella Claudio; Sasaki Yusuke; Ambo Akihiro; Marczak Ewa D; Lazarus Lawrence H; Salvadori Severo
Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic.
Journal of medicinal chemistry 2008;51(16):5109-17.
2008: Salvadori Severo; Fiorini Stella; Trapella Claudio; Porreca Frank; Davis Peg; Sasaki Yusuke; Ambo Akihiro; Marczak Ewa D; Lazarus Lawrence H; Balboni Gianfranco
Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502).
Bioorganic & medicinal chemistry 2008;16(6):3032-8.
2008: Vergura Raffaella; Balboni Gianfranco; Spagnolo Barbara; Gavioli Elaine; Lambert David G; McDonald John; Trapella Claudio; Lazarus Lawrence H; Regoli Domenico; Guerrini Remo; Salvadori Severo; Caló Girolamo
Anxiolytic- and antidepressant-like activities of H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), a novel selective delta opioid receptor agonist.
Peptides 2008;29(1):93-103.
2007: Shiotani Kimitaka; Miyazaki Anna; Li Tingyou; Tsuda Yuko; Yokoi Toshio; Ambo Akihiro; Sasaki Yusuke; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H; Okada Yoshio
Synthesis of opioidmimetics, 3-[H-Dmt-NH(CH(2))(m)]-6-[H-Dmt-NH(CH(2))(n)]-2(1H)-pyrazinones, and studies on structure-activity relationships.
Medicinal chemistry (Shariqah (United Arab Emirates)) 2007;3(6):583-98.
2007: Salvadori Severo; Trapella Claudio; Fiorini Stella; Negri Lucia; Lattanzi Roberta; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H; Balboni Gianfranco
A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic.
Bioorganic & medicinal chemistry 2007;15(22):6876-81.
2007: Shiotani Kimitaka; Li Tingyou; Miyazaki Anna; Tsuda Yuko; Yokoi Toshio; Ambo Akihiro; Sasaki Yusuke; Bryant Sharon D; Lazarus Lawrence H; Okada Yoshio
Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform.
Bioorganic & medicinal chemistry letters 2007;17(21):5768-71.
2007: Marczak Ewa D; Jinsmaa Yunden; Li Tingyou; Bryant Sharon D; Tsuda Yuko; Okada Yoshio; Lazarus Lawrence H
[N-allyl-Dmt1]-endomorphins are micro-opioid receptor antagonists lacking inverse agonist properties.
The Journal of pharmacology and experimental therapeutics 2007;323(1):374-80.
2007: Li Tingyou; Shiotani Kimitaka; Miyazaki Anna; Tsuda Yuko; Ambo Akihiro; Sasaki Yusuke; Jinsmaa Yunden; Marczak Ewa; Bryant Sharon D; Lazarus Lawrence H; Okada Yoshio
Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.
Journal of medicinal chemistry 2007;50(12):2753-66.
2007: Balboni Gianfranco; Onnis Valentina; Congiu Cenzo; Zotti Margherita; Sasaki Yusuke; Ambo Akihiro; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H; Lazzari Ilaria; Trapella Claudio; Salvadori Severo
Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore.
Bioorganic & medicinal chemistry 2007;15(9):3143-51.
2007: Li Tingyou; Jinsmaa Yunden; Nedachi Masahiro; Miyazaki Anna; Tsuda Yuko; Ambo Akihiro; Sasaki Yusuke; Bryant Sharon D; Marczak Ewa; Li Qiang; Swartzwelder H Scott; Lazarus Lawrence H; Okada Yoshio
Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists.
Bioorganic & medicinal chemistry 2007;15(3):1237-51.
2006: Shiotani Kimitaka; Li Tingyou; Miyazaki Anna; Tsuda Yuko; Bryant Sharon D; Ambo Akihiro; Sasaki Yusuke; Lazarus Lawrence H; Okada Yoshio
Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity.
Bioorganic & medicinal chemistry letters 2006;16(22):5793-6.
2006: Neumeyer John L; Peng Xuemei; Knapp Brian I; Bidlack Jean M; Lazarus Lawrence H; Salvadori Severo; Trapella Claudio; Balboni Gianfranco
New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.
Journal of medicinal chemistry 2006;49(18):5640-3.
2006: Balboni Gianfranco; Onnis Valentina; Congiu Cenzo; Zotti Margherita; Sasaki Yusuke; Ambo Akihiro; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H; Trapella Claudio; Salvadori Severo
Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.
Journal of medicinal chemistry 2006;49(18):5610-7.
2006: Ballet Steven; Salvadori Severo; Trapella Claudio; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H; Negri Lucia; Giannini Elisa; Lattanzi Roberta; Tourwé Dirk; Balboni Gianfranco
New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands.
Journal of medicinal chemistry 2006;49(13):3990-3.
2006: Jinsmaa Yunden; Marczak Ewa; Fujita Yoshio; Shiotani Kimitaka; Miyazaki Anna; Li Tingyou; Tsuda Yuko; Ambo Akihiro; Sasaki Yusuke; Bryant Sharon D; Okada Yoshio; Lazarus Lawrence H
Potent in vivo antinociception and opioid receptor preference of the novel analogue [Dmt1]endomorphin-1.
Pharmacology, biochemistry, and behavior 2006;84(2):252-8.
2006: Vázquez M Eugenio; Blanco Juan B; Salvadori Severo; Trapella Claudio; Argazzi Roberto; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H; Negri Lucia; Giannini Elisa; Lattanzi Roberta; Colucci Mariantonella; Balboni Gianfranco
6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.
Journal of medicinal chemistry 2006;49(12):3653-8.
2006: Li Tingyou; Tsuda Yuko; Minoura Katsuhiko; In Yasuko; Ishida Toshimasa; Lazarus Lawrence H; Okada Yoshio
Enantioselective synthesis of a phenylalanine library containing alkyl groups on the aromatic moiety: confirmation of stereostructure by X-ray analysis.
Chemical & pharmaceutical bulletin 2006;54(6):873-7.
2005: Balboni Gianfranco; Guerrini Remo; Salvadori Severo; Negri Lucia; Giannini Elisa; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H
Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).
Journal of medicinal chemistry 2005;48(26):8112-4.
2005: Li Tingyou; Fujita Yoshio; Shiotani Kimitaka; Miyazaki Anna; Tsuda Yuko; Ambo Akihiro; Sasaki Yusuke; Jinsmaa Yunden; Marczak Ewa; Bryant Sharon D; Salvadori Severo; Lazarus Lawrence H; Okada Yoshio
Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists.
Journal of medicinal chemistry 2005;48(25):8035-44.
2005: Li Tingyou; Shiotani Kimitaka; Miyazaki Anna; Fujita Yoshio; Tsuda Yuko; Ambo Akihiro; Sasaki Yusuke; Jinsmaa Yunden; Marczak Ewa; Bryant Sharon D; Lazarus Lawrence H; Okada Yoshio
New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif.
Bioorganic & medicinal chemistry letters 2005;15(24):5517-20.
2005: In Yasuko; Minoura Katsuhiko; Tomoo Koji; Sasaki Yusuke; Lazarus Lawrence H; Okada Yoshio; Ishida Toshimasa
Structural function of C-terminal amidation of endomorphin. Conformational comparison of mu-selective endomorphin-2 with its C-terminal free acid, studied by 1H-NMR spectroscopy, molecular calculation, and X-ray crystallography.
The FEBS journal 2005;272(19):5079-97.
2005: Miyazaki Anna; Fujisawa Yutaka; Shiotani Kimitaka; Fujita Yoshio; Li Tingyou; Tsuda Yuko; Yokoi Toshio; Bryant Sharon D; Lazarus Lawrence H; Okada Yoshio
Studies on the mechanism of 1,2-dihydropyrazin-2-one ring formation from dipeptidyl chloromethyl ketone and its chemical properties: immediate deamination during catalytic hydrogenation.
Chemical & pharmaceutical bulletin 2005;53(9):1152-8.
2005: Balboni Gianfranco; Cocco Maria Teresa; Salvadori Severo; Romagnoli Romeo; Sasaki Yusuke; Okada Yoshio; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H
From the potent and selective mu opioid receptor agonist H-Dmt-d-Arg-Phe-Lys-NH(2) to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH.
Journal of medicinal chemistry 2005;48(17):5608-11.
2005: Tryoen-Tóth P; Décaillot F M; Filliol D; Befort K; Lazarus L H; Schiller P W; Schmidhammer H; Kieffer B L
Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors.
The Journal of pharmacology and experimental therapeutics 2005;313(1):410-21.
2005: Jinsmaa Yunden; Fujita Yoshio; Shiotani Kimitaka; Miyazaki Anna; Li Tingyou; Tsuda Yuko; Okada Yoshio; Ambo Akihiro; Sasaki Yusuke; Bryant Sharon D; Lazarus Lawrence H
Differentiation of opioid receptor preference by [Dmt1]endomorphin-2-mediated antinociception in the mouse.
European journal of pharmacology 2005;509(1):37-42.
2005: Fujita Yoshio; Tsuda Yuko; Motoyama Takashi; Li Tingyou; Miyazaki Anna; Yokoi Toshio; Sasaki Yusuke; Ambo Akihiro; Niizuma Hideko; Jinsmaa Yunden; Bryant Sharon D; Lazarus Lawrence H; Okada Yoshio
Studies on the structure-activity relationship of 2',6'-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH(3).
Bioorganic & medicinal chemistry letters 2005;15(3):599-602.
2005: Li Tingyou; Fujita Yoshio; Tsuda Yuko; Miyazaki Anna; Ambo Akihiro; Sasaki Yusuke; Jinsmaa Yunden; Bryant Sharon D; Lazarus Lawrence H; Okada Yoshio
Development of potent mu-opioid receptor ligands using unique tyrosine analogues of endomorphin-2.
Journal of medicinal chemistry 2005;48(2):586-92.
2004: Balboni Gianfranco; Salvadori Severo; Dal Piaz Alessandro; Bortolotti Fabrizio; Argazzi Roberto; Negri Lucia; Lattanzi Roberta; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H
Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic.
Journal of medicinal chemistry 2004;47(26):6541-6.
2004: Balboni Gianfranco; Salvadori Severo; Guerrini Remo; Negri Lucia; Giannini Elisa; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H
Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism.
Journal of medicinal chemistry 2004;47(16):4066-71.
2004: Fujita Yoshio; Tsuda Yuko; Li Tingyou; Motoyama Takashi; Takahashi Motohiro; Shimizu Yoshiro; Yokoi Toshio; Sasaki Yusuke; Ambo Akihiro; Kita Atsuko; Jinsmaa Yunden; Bryant Sharon D; Lazarus Lawrence H; Okada Yoshio
Development of potent bifunctional endomorphin-2 analogues with mixed mu-/delta-opioid agonist and delta-opioid antagonist properties.
Journal of medicinal chemistry 2004;47(14):3591-9.
2004: Jinsmaa Yunden; Miyazaki Anna; Fujita Yoshio; Li Tingyou; Fujisawa Yutaka; Shiotani Kimitaka; Tsuda Yuko; Yokoi Toshio; Ambo Akihiro; Sasaki Yusuke; Bryant Sharon D; Lazarus Lawrence H; Okada Yoshio
Oral bioavailability of a new class of micro-opioid receptor agonists containing 3,6-bis[Dmt-NH(CH(2))(n)]-2(1H)-pyrazinone with central-mediated analgesia.
Journal of medicinal chemistry 2004;47(10):2599-610.
2004: Jinsmaa Yunden; Okada Yoshio; Tsuda Yuko; Shiotani Kimitaka; Sasaki Yusuke; Ambo Akihiro; Bryant Sharon D; Lazarus Lawrence H
Novel 2',6'-dimethyl-L-tyrosine-containing pyrazinone opioid mimetic mu-agonists with potent antinociceptive activity in mice.
The Journal of pharmacology and experimental therapeutics 2004;309(1):432-8.
2003: Balboni Gianfranco; Salvadori Severo; Guerrini Remo; Negri Lucia; Giannini Elisa; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H
Synthesis and opioid activity of N,N-dimethyl-Dmt-Tic-NH-CH(R)-R' analogues: acquisition of potent delta antagonism.
Bioorganic & medicinal chemistry 2003;11(24):5435-41.
2003: Okada Yoshio; Tsuda Yuko; Fujita Yoshio; Yokoi Toshio; Sasaki Yusuke; Ambo Akihiro; Konishi Ryoji; Nagata Mitsuhiro; Salvadori Severo; Jinsmaa Yunden; Bryant Sharon D; Lazarus Lawrence H
Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia.
Journal of medicinal chemistry 2003;46(15):3201-9.
2003: Okada Yoshio; Fujita Yoshio; Motoyama Takashi; Tsuda Yuko; Yokoi Toshio; Li Tingyou; Sasaki Yusuke; Ambo Akihiro; Jinsmaa Yunden; Bryant Sharon D; Lazarus Lawrence H
Structural studies of [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues: enhanced activity and cis orientation of the Dmt-Pro amide bond.
Bioorganic & medicinal chemistry 2003;11(9):1983-94.
2003: Bryant Sharon D; Jinsmaa Yunden; Salvadori Severo; Okada Yoshio; Lazarus Lawrence H
Dmt and opioid peptides: a potent alliance.
Biopolymers 2003;71(2):86-102.
2002: Balboni Gianfranco; Salvadori Severo; Guerrini Remo; Negri Lucia; Giannini Elisa; Jinsmaa Yunden; Bryant Sharon D; Lazarus Lawrence H
Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.
Journal of medicinal chemistry 2002;45(25):5556-63.
2002: Bryant Sharon D; George Clifford; Flippen-Anderson Judith L; Deschamps Jeffrey R; Salvadori Severo; Balboni Gianfranco; Guerrini Remo; Lazarus Lawrence H
Crystal structures of dipeptides containing the Dmt-Tic pharmacophore.
Journal of medicinal chemistry 2002;45(25):5506-13.
2002: Balboni Gianfranco; Guerrini Remo; Salvadori Severo; Bianchi Clementina; Rizzi Daniela; Bryant Sharon D; Lazarus Lawrence H
Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.
Journal of medicinal chemistry 2002;45(3):713-20.
2002: Okada Yoshio; Tsuda Yuko; Bryant Sharon D; Lazarus Lawrence H
Endomorphins and related opioid peptides.
Vitamins and hormones 2002;65():257-79.
2001: Lovekamp T; Cooper P S; Hardison J; Bryant S D; Guerrini R; Balboni G; Salvadori S; Lazarus L H
Inhibition of human multidrug resistance P-glycoprotein 1 by analogues of a potent delta-opioid antagonist.
Brain research 2001;902(1):131-4.
2000: Santagada V; Balboni G; Caliendo G; Guerrini R; Salvadori S; Bianchi C; Bryant S D; Lazarus L H
Assessment of substitution in the second pharmacophore of Dmt-Tic analogues.
Bioorganic & medicinal chemistry letters 2000;10(24):2745-8.
2000: Balboni G; Salvadori S; Guerrini R; Bianchi C; Santagada V; Calliendo G; Bryant S D; Lazarus L H
Opioid pseudopeptides containing heteroaromatic or heteroaliphatic nuclei.
Peptides 2000;21(11):1663-71.
2000: Labarre M; Butterworth J; St-Onge S; Payza K; Schmidhammer H; Salvadori S; Balboni G; Guerrini R; Bryant S D; Lazarus L H
Inverse agonism by Dmt-Tic analogues and HS 378, a naltrindole analogue.
European journal of pharmacology 2000;406(1):R1-3.
2000: Okada Y; Fukumizu A; Takahashi M; Shimizu Y; Tsuda Y; Yokoi T; Bryant S D; Lazarus L H
Synthesis of stereoisomeric analogues of endomorphin-2, H-Tyr-Pro-Phe-Phe-NH(2), and examination of their opioid receptor binding activities and solution conformation.
Biochemical and biophysical research communications 2000;276(1):7-11.
2000: Monory K; Bryant S D; Kertész I; Balboni G; Guerrini R; Tóth G; Salvadori S; Lazarus L H; Borsodi A
Characterization of N,N(Me)2-Dmt-Tic-OH, a delta selective opioid dipeptide antagonist.
Neuroreport 2000;11(10):2083-6.
1999: Salvadori S; Guerrini R; Balboni G; Bianchi C; Bryant S D; Cooper P S; Lazarus L H
Further studies on the Dmt-Tic pharmacophore: hydrophobic substituents at the C-terminus endow delta antagonists to manifest mu agonism or mu antagonism.
Journal of medicinal chemistry 1999;42(24):5010-9.
1999: Okada Y; Fukumizu A; Takahashi M; Yokoi T; Tsuda Y; Bryant S D; Lazarus L H
Synthesis of pyrazinone ring-containing opioid mimetics and examination of their opioid receptor-binding activity.
Chemical & pharmaceutical bulletin 1999;47(8):1193-5.
1999: Lazarus L H; Bryant S D; Cooper P S; Salvadori S
What peptides these deltorphins be.
Progress in neurobiology 1999;57(4):377-420.
1999: Marastoni M; Guerrini R; Balboni G; Salvadori S; Fantin G; Fogagnolo M; Lazarus L H; Tomatis R
Opioid deltorphin C analogues containing cis- or trans-2- or 3- or 4-aminocyclohexanecarboxylic acid residues.
Arzneimittel-Forschung 1999;49(1):6-12.
1998: Okada Y; Tsukatani M; Taguchi H; Yokoi T; Bryant S D; Lazarus L H
Amino acids and peptides. LII. Design and synthesis of opioid mimetics containing a pyrazinone ring and examination of their opioid receptor binding activity.
Chemical & pharmaceutical bulletin 1998;46(9):1374-82.
1998: Bryant S D; Salvadori S; Cooper P S; Lazarus L H
New delta-opioid antagonists as pharmacological probes.
Trends in pharmacological sciences 1998;19(2):42-6.
1998: Guerrini R; Capasso A; Marastoni M; Bryant S D; Cooper P S; Lazarus L H; Temussi P A; Salvadori S
Rational design of dynorphin A analogues with delta-receptor selectivity and antagonism for delta- and kappa-receptors.
Bioorganic & medicinal chemistry 1998;6(1):57-62.
1997: Capasso A; Amodeo P; Balboni G; Guerrini R; Lazarus L H; Temussi P A; Salvadori S
Design of mu selective opioid dipeptide antagonists.
FEBS letters 1997;417(1):141-4.
1997: Salvadori S; Balboni G; Guerrini R; Tomatis R; Bianchi C; Bryant S D; Cooper P S; Lazarus L H
Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.
Journal of medicinal chemistry 1997;40(19):3100-8.
1997: Tomatis R; Marastoni M; Balboni G; Guerrini R; Capasso A; Sorrentino L; Santagada V; Caliendo G; Lazarus L H; Salvadori S
Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides.
Journal of medicinal chemistry 1997;40(18):2948-52.
1997: Bryant S D; Guerrini R; Salvadori S; Bianchi C; Tomatis R; Attila M; Lazarus L H
Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues.
Journal of medicinal chemistry 1997;40(16):2579-87.
1997: Crescenzi O; Fraternali F; Picone D; Tancredi T; Balboni G; Guerrini R; Lazarus L H; Salvadori S; Temussi P A
Design and solution structure of a partially rigid opioid antagonist lacking the basic center--models of antagonism.
European journal of biochemistry / FEBS 1997;247(1):66-73.
1997: Guerrini R; Calo G; Rizzi A; Bianchi C; Lazarus L H; Salvadori S; Temussi P A; Regoli D
Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin-(1-13)-peptide amide.
Journal of medicinal chemistry 1997;40(12):1789-93.
1997: Salvadori S; Picone D; Tancredi T; Guerrini R; Spadaccini R; Lazarus L H; Regoli D; Temussi P A
Solution conformation of nociceptin.
Biochemical and biophysical research communications 1997;233(3):640-3.
1997: Bryant S D; Balboni G; Guerrini R; Salvadori S; Tomatis R; Lazarus L H
Opioid diketopiperazines: refinement of the delta opioid antagonist pharmacophore.
Biological chemistry 1997;378(2):107-14.
1997: Balboni G; Guerrini R; Salvadori S; Tomatis R; Bryant S D; Bianchi C; Attila M; Lazarus L H
Opioid diketopiperazines: synthesis and activity of a prototypic class of opioid antagonists.
Biological chemistry 1997;378(1):19-29.
1996: Guerrini R; Capasso A; Sorrentino L; Anacardio R; Bryant S D; Lazarus L H; Attila M; Salvadori S
Opioid receptor selectivity alteration by single residue replacement: synthesis and activity profile of [Dmt1]deltorphin B.
European journal of pharmacology 1996;302(1-3):37-42.
1996: Breveglieri A; Guerrini R; Salvadori S; Bianchi C; Bryant S D; Attila M; Lazarus L H
Design and synthesis of 1-aminocycloalkane-1-carboxylic acid-substituted deltorphin analogues: unique delta and mu opioid activity in modified peptides.
Journal of medicinal chemistry 1996;39(3):773-80.
1996: Lazarus L H; Bryant S D; Salvadori S; Attila M; Sargent Jones L
Opioid infidelity: novel opioid peptides with dual high affinity for delta- and mu-receptors.
Trends in neurosciences 1996;19(1):31-5.
1996: Capasso A; Guerrini R; Balboni G; Sorrentino L; Temussi P; Lazarus L H; Bryant S D; Salvadori S
Dmt-Tic-OH a highly selective and potent delta-opioid dipeptide receptor antagonist after systemic administration in the mouse.
Life sciences 1996;59(8):PL93-8.
1995: Balboni G; Salvadori S; D'Angeli F; Marchetti P; Lazarus L H; Bryant S D; Bianchi C
Single diastereomeric desaminotyrosylalanyl tetra- and heptapeptides with opioid antagonistic activity.
International journal of peptide and protein research 1995;45(2):187-93.
1994: Tancredi T; Salvadori S; Amodeo P; Picone D; Lazarus L H; Bryant S D; Guerrini R; Marzola G; Temussi P A
Conversion of enkephalin and dermorphin into delta-selective opioid antagonists by single-residue substitution.
European journal of biochemistry / FEBS 1994;224(1):241-7.
1994: Lazarus L H; Bryant S D; Attila M; Salvadori S
Frog skin opioid peptides: a case for environmental mimicry.
Environmental health perspectives 1994;102(8):648-54.
1994: Bryant S D; Attila M; Salvadori S; Guerrini R; Lazarus L H
Molecular dynamics conformations of deltorphin analogues advocate delta opioid binding site models.
Peptide research 1994;7(4):175-84.
1994: Temussi P A; Salvadori S; Amodeo P; Bianchi C; Guerrini R; Tomatis R; Lazarus L H; Picone D; Tancredi T
Selective opioid dipeptides.
Biochemical and biophysical research communications 1994;198(3):933-9.
1993: Attila M; Salvadori S; Balboni G; Bryant S D; Lazarus L H
Synthesis and receptor binding analysis of dermorphin hepta-, hexa- and pentapeptide analogues. Evidence for one- and two-side binding models for the mu-opioid receptor.
International journal of peptide and protein research 1993;42(6):550-9.
1993: Salvadori S; Bryant S D; Bianchi C; Balboni G; Scaranari V; Attila M; Lazarus L H
Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors.
Journal of medicinal chemistry 1993;36(24):3748-56.
1993: Lazarus L H; Attila M
The toad, ugly and venomous, wears yet a precious jewel in his skin.
Progress in neurobiology 1993;41(4):473-507.
1993: Lazarus L H; Salvadori S; Attila M; Grieco P; Bundy D M; Wilson W E; Tomatis R
Interaction of deltorphin with opioid receptors: molecular determinants for affinity and selectivity.
Peptides 1993;14(1):21-8.
1993: Salvadori S; Bryant S D; Temussi P A; Bundy D M; Attila M; Tomatis R; Lazarus L H
Relationship between receptor affinity and topography of N-terminally extended and bridged [Tyr1-->Asp4]deltorphin C analogues: novel probes for the delta-opioid receptor.
European journal of pharmacology 1993;230(3):357-61.
1992: Salvadori S; Bianchi C; Lazarus L H; Scaranari V; Attila M; Tomatis R
Para-substituted Phe3 deltorphin analogues: enhanced selectivity of halogenated derivatives for delta opioid receptor sites.
Journal of medicinal chemistry 1992;35(25):4651-7.
1992: Lazarus L H; Salvadori S; Balboni G; Tomatis R; Wilson W E
Stereospecificity of amino acid side chains in deltorphin defines binding to opioid receptors.
Journal of medicinal chemistry 1992;35(7):1222-7.
1991: Marastoni M; Tomatis R; Balboni G; Salvadori S; Lazarus L H
On the degradation of the deltorphin peptides by plasma and brain homogenate.
Farmaco (Società chimica italiana : 1989) 1991;46(11):1273-9.
1991: Lazarus L H; Salvadori S; Tomatis R; Wilson W E
Opioid receptor selectivity reversal in deltorphin tetrapeptide analogues.
Biochemical and biophysical research communications 1991;178(1):110-5.
1991: Lazarus L H; Salvadori S; Santagada V; Tomatis R; Wilson W E
Function of negative charge in the "address domain" of deltorphins.
Journal of medicinal chemistry 1991;34(4):1350-5.
1990: Lazarus L H; Wilson W E; Guglietta A; de Castiglione R
Dermorphin interaction with rat brain opioid receptors: involvement of hydrophobic sites in the binding domain.
Molecular pharmacology 1990;37(6):886-92.
1989: Guglietta A; Irons B J; Lazarus L H; de Castiglione R; Melchiorri P
Dimeric dermorphin peptides: central administration suppresses gastric acid secretion through interaction with mu-type opioid receptor.
Methods and findings in experimental and clinical pharmacology 1989;11(11):663-70.
1989: Wilson W E; Lazarus L H; Tomer K B
Bradykinin and kininogens in bovine milk.
The Journal of biological chemistry 1989;264(30):17777-83.
1989: Guglietta A; Nardi R V; Lazarus L H
Indomethacin (i.c.v.) reverses the inhibitory action of peptides on gastric secretion.
European journal of pharmacology 1989;170(1-2):87-90.
1989: Lazarus L H; Wilson W E; de Castiglione R; Guglietta A
Dermorphin gene sequence peptide with high affinity and selectivity for delta-opioid receptors.
The Journal of biological chemistry 1989;264(6):3047-50.
1989: Lazarus L H; Guglietta A; Wilson W E; Irons B J; de Castiglione R
Dimeric dermorphin analogues as mu-receptor probes on rat brain membranes. Correlation between central mu-receptor potency and suppression of gastric acid secretion.
The Journal of biological chemistry 1989;264(1):354-62.
1989: Renda T; D'Este L; Fasolo A; Lazarus L H; Minniti F; Erspamer V
Brain-gut-skin peptides: an update overview.
Archives of histology and cytology 1989;52 Suppl():317-23.
1988: Guglietta A; Irons B J; Lazarus L H; Sivam S P
Effects and mechanism of action of lithium chloride on gastric acid secretion in rats.
Gastroenterology 1988;95(6):1454-9.
1988: Guglietta A; Irons B J; Lazarus L H
Effect of bombesin, dermorphin and salmon calcitonin on gastric acid secretion in rats.
Methods and findings in experimental and clinical pharmacology 1988;10(8):481-5.
1988: Lazarus L H; Irons B J; Grimes L M; Wilson W E; Guglietta A; Yajima H
Assessment of neuromedin B polyclonal antibodies as molecular probes in neural tissue.
Journal of neuroscience methods 1988;23(2):161-72.
1988: Lazarus L H; Guglietta A; Wilson W E; Grimes L M; Irons B J; Yajima H
Neuromedin B: physiological and pharmacological perturbations.
Annals of the New York Academy of Sciences 1988;547():404-14.
1987: Guglietta A; Irons B J; Lazarus L H; Melchiorri P
Structure-activity relationship of dermorphin on gastric secretion.
Endocrinology 1987;120(5):2137-43.
1986: Lazarus L H; Gaudino G; Wilson W E; Erspamer V
An immunoreactive peptide in milk contains bombesin-like bioactivity.
Experientia 1986;42(7):822-3.
1985: Gaudino G; Fasolo A; Merlo G; Lazarus L H; Renda T; D'Este L; Vandesande F
Active peptides from amphibian skin are also amphibian neuropeptides.
Peptides 1985;6 Suppl 3():209-13.
1985: Guglietta A; Strunk C L; Irons B J; Lazarus L H
Central neuromodulation of gastric acid secretion by bombesin-like peptides.
Peptides 1985;6 Suppl 3():75-81.
1985: Lazarus L H; Wilson W E; Gaudino G; Irons B J; Guglietta A
Evolutionary relationship between nonmammalian and mammalian peptides.
Peptides 1985;6 Suppl 3():295-307.

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