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Michelle Le Beau

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Aparna Vasanthakumar; Matthew H Zegarek; John Anastasi; Elizabeth M Davis; Adam R Karpf; Masha Kocherginsky; Michelle M Le Beau; Janet B Lepore; Petra A Link; Mahi Singh; Lucy A Godley
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis.
Nader Omidvar; Sabina Sevcikova; Thelma R Tennant; Bin Yin; Karen L Himmel; Letetia Jones; David A Largaespada; Michelle M Le Beau; Mei Lin Maunakea; Scott C Kogan
PML-RARα co-operates with Sox4 in acute myeloid leukemia development in mice.
Xi Jiang; Rejani B Kunjamma; Richard A Larson; Michelle M Le Beau; Yuanyuan Li; Zejuan Li; James C Mulloy; Mary Beth Neilly; Colles Price; Haomin Ren; Janet D Rowley; Justin Salat; Robert K Slany; Mark Wunderlich; Yanming Zhang; Ping Chen; Sandeep Gurbuxani; Chunjiang He; Gia-Ming Hong; Hao Huang; Stephen Arnovitz; Jianjun Chen
MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia.

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All Publications

2013: Aparna Vasanthakumar; Matthew H Zegarek; John Anastasi; Elizabeth M Davis; Adam R Karpf; Masha Kocherginsky; Michelle M Le Beau; Janet B Lepore; Petra A Link; Mahi Singh; Lucy A Godley
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis.
Blood 2013;121(11):2059-63.
2013: Nader Omidvar; Sabina Sevcikova; Thelma R Tennant; Bin Yin; Karen L Himmel; Letetia Jones; David A Largaespada; Michelle M Le Beau; Mei Lin Maunakea; Scott C Kogan
PML-RARα co-operates with Sox4 in acute myeloid leukemia development in mice.
Haematologica 2013;98(3):424-7.
2012: Xi Jiang; Rejani B Kunjamma; Richard A Larson; Michelle M Le Beau; Yuanyuan Li; Zejuan Li; James C Mulloy; Mary Beth Neilly; Colles Price; Haomin Ren; Janet D Rowley; Justin Salat; Robert K Slany; Mark Wunderlich; Yanming Zhang; Ping Chen; Sandeep Gurbuxani; Chunjiang He; Gia-Ming Hong; Hao Huang; Stephen Arnovitz; Jianjun Chen
MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(47):19397-402.
2012: Xi Jiang; Rejani B Kunjamma; Richard A Larson; Michelle M Le Beau; Yuanyuan Li; Zejuan Li; Paul P Liu; Jun Lu; Jonathan M Matthews; Mary Beth Neilly; Colles Price; Haomin Ren; Robert K Slany; Jinhua Wang; Xiao Wang; Mengyi Xu; Dewen You; Jiwang Zhang; Shuodan Zhang; Ping Chen; Abdel Elkahloun; Sandeep Gurbuxani; Chuan He; Chunjiang He; Gia-Ming Hong; Hao Huang; Stephen Arnovitz; Jianjun Chen
Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.
Cancer cell 2012;22(4):524-35.
2012: Lucy A Godley; Michelle M Le Beau
The histone code and treatments for acute myeloid leukemia.
The New England journal of medicine 2012;366(10):960-1.
2012: Zejuan Li; Paul P Liu; Bob Lowenberg; Yves lussier; Kati Maharry; Guido Marcucci; Mary Beth Neilly; Colles Price; Michael D Radmacher; Janet D Rowley; Peter J M Valk; Xinan Yang; Yanming Zhang; Zhiyu Zhang; Ping Chen; Ruud Delwel; Konstanze Dohner; Abdel Elkahloun; Chunjiang He; Miao He; Hao Huang; Xi Jiang; Richard A Larson; Michelle M Le Beau; Yuanyuan Li; Stephen Arnovitz; Clara D Bloomfield; Lars Bullinger; Michael A Caligiuri; Jianjun Chen
Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.
Blood 2012;119(10):2314-24.
2012: A Stoddart; Thelma R Tennant; John Anastasi; F M Brodsky; Anthony A Fernald; Michelle M Le Beau
The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice.
Oncogene 2012;31(4):494-506.
2012: Zejuan Li; Paul P Liu; Bob Lowenberg; Jun Lu; James C Mulloy; Mary Beth Neilly; Chen Shen; Peter J M Valk; James Vardiman; Yungui Wang; Minjie Wei; Mark Wunderlich; Nancy J Zeleznik-Le; Jiwang Zhang; Jun Zhang; Zhiyu Zhang; Ping Chen; Ruud Delwel; Abdel Elkahloun; Chunjiang He; Miao He; Hao Huang; Elizabeth Hyjek; Xi Jiang; Jie Jin; Michelle M Le Beau; Yuanyuan Li; Stephen Arnovitz; Donglin Cao; Jianjun Chen
miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia.
Nature communications 2012;3():688.
2011: Olatoyosi Odenike; John Anastasi; Michelle M Le Beau
Myelodysplastic syndromes.
Clinics in laboratory medicine 2011;31(4):763-84.
2011: Lucy A Godley; John Cunningham; M Eileen Dolan; R Stephanie Huang; Sandeep Gurbuxani; Megan E McNerney; Richard A Larson; Hoyee Leong; Yves lussier; Kenan Onel; Olatoyosi Odenike; Wendy Stock; Kevin P White; Michelle M Le Beau
An integrated genomic approach to the assessment and treatment of acute myeloid leukemia.
Seminars in oncology 2011;38(2):215-24.
2011: Richard A Larson; Michelle M Le Beau
Prognosis and therapy when acute promyelocytic leukemia and other "good risk" acute myeloid leukemias occur as a therapy-related myeloid neoplasm.
Mediterranean journal of hematology and infectious diseases 2011;3(1):e2011032.
2011: Angela Stoddart; Jianghong Wang; Kevin P White; David J Young; Elizabeth Bartom; Rachel Bergerson; Elizabeth M Davis; Anthony A Fernald; Richard A Larson; Megan E McNerney; Zhijian Qian; Michelle M Le Beau
Genetic pathways leading to therapy-related myeloid neoplasms.
Mediterranean journal of hematology and infectious diseases 2011;3(1):e2011019.
2010: Letetia Jones; Guangwei Wei; Sabina Sevcikova; Vernon Phan; Sachi Jain; Angell Shieh; Jasmine C Y Wong; Min Li; Joshua Dubansky; Mei Lin Maunakea; Rachel Ochoa; George Zhu; Thelma R Tennant; Kevin M Shannon; Scott W Lowe; Michelle M Le Beau; Scott C Kogan
Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia.
The Journal of experimental medicine 2010;207(12):2581-94.
2010: Mary Mohrin; Emer Bourke; David Alexander; Matthew R Warr; Keegan Barry-Holson; Michelle M Le Beau; Ciaran G Morrison; Emmanuelle Passegué
Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis.
Cell stem cell 2010;7(2):174-85.
2010: Lucy A Godley; Uchenna O Njiaju; Margaret Green; Howard Weiner; Shang Lin; Olatoyosi Odenike; Elizabeth Rich; Andrew S Artz; Koen van Besien; Christopher K Daugherty; Yanming Zhang; Michelle M Le Beau; Wendy Stock; Richard A Larson
Treatment of therapy-related myeloid neoplasms with high-dose cytarabine/mitoxantrone followed by hematopoietic stem cell transplant.
Leukemia & lymphoma 2010;51(6):995-1006.
2010: Jianghong Wang; Anthony A Fernald; John Anastasi; Michelle M Le Beau; Zhijian Qian
Haploinsufficiency of Apc leads to ineffective hematopoiesis.
Blood 2010;115(17):3481-8.
2010: Zhijian Qian; John M Joslin; Thelma R Tennant; Shalini C Reshmi; David J Young; Angela Stoddart; Richard A Larson; Michelle M Le Beau
Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia.
Chemico-biological interactions 2010;184(1-2):50-7.
2010: Aparna Palakodeti; Isabelle Lucas; Yanwen Jiang; David J Young; Anthony A Fernald; Theodore Karrison; Michelle M Le Beau
Impaired replication dynamics at the FRA3B common fragile site.
Human molecular genetics 2010;19(1):99-110.
2009: Yanwen Jiang; Isabelle Lucas; David J Young; Elizabeth M Davis; Theodore Karrison; Joshua S Rest; Michelle M Le Beau
Common fragile sites are characterized by histone hypoacetylation.
Human molecular genetics 2009;18(23):4501-12.
2009: Zhijian Qian; L Mao; Anthony A Fernald; H Yu; R Luo; Y Jiang; John Anastasi; P J Valk; R Delwel; Michelle M Le Beau
Enhanced expression of FHL2 leads to abnormal myelopoiesis in vivo.
Leukemia 2009;23(9):1650-7.
2009: James W Vardiman; Jüergen Thiele; Daniel A Arber; Richard D Brunning; Michael J Borowitz; Anna Porwit; Nancy Lee Harris; Michelle M Le Beau; Eva Hellström-Lindberg; Ayalew Tefferi; Clara D Bloomfield
The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes.
Blood 2009;114(5):937-51.
2009: Omar Abdel-Wahab; Ann Mullally; Cyrus V Hedvat; Guillermo Garcia-Manero; Jay Patel; Martha Wadleigh; Sebastien Malinge; JinJuan Yao; Outi Kilpivaara; Rukhmi Bhat; Kety Huberman; Sabrena Thomas; Igor Dolgalev; Adriana Heguy; Elisabeth Paietta; Michelle M Le Beau; Miloslav Beran; Martin S Tallman; Benjamin L Ebert; Hagop M Kantarjian; Richard M Stone; D Gary Gilliland; John D Crispino; Ross Levine
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.
Blood 2009;114(1):144-7.
2009: Jeffrey A Knight; Andrew D Skol; Abhijit Shinde; Darcie Hastings; Richard A Walgren; Jin Shao; Thelma R Tennant; Mekhala Banerjee; James M Allan; Michelle M Le Beau; Richard A Larson; Timothy A Graubert; Nancy J Cox; Kenan Onel
Genome-wide association study to identify novel loci associated with therapy-related myeloid leukemia susceptibility.
Blood 2009;113(22):5575-82.
2008: Jasmine C Wong; Michelle M Le Beau; Kevin Shannon
Tumor suppressor gene inactivation in myeloid malignancies.
Best practice & research. Clinical haematology 2008;21(4):601-14.
2008: Zejuan Li; Jun Lu; Miao Sun; Shuangli Mi; Hao Zhang; Roger T Luo; Ping Chen; Yungui Wang; Ming Yan; Zhijian Qian; Mary Beth Neilly; Jie Jin; Yanming Zhang; Stefan K Bohlander; Dong-Er Zhang; Richard A Larson; Michelle M Le Beau; Michael J Thirman; Todd R Golub; Janet D Rowley; Jianjun Chen
Distinct microRNA expression profiles in acute myeloid leukemia with common translocations.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15535-40.
2008: Zhijian Qian; Lina Chen; Anthony A Fernald; Bart Williams; Michelle M Le Beau
A critical role for Apc in hematopoietic stem and progenitor cell survival.
The Journal of experimental medicine 2008;205(9):2163-75.
2008: Nathan Ellis; Dezheng Huo; Ozlem Yildiz; Lisa J Worrillow; Mekhala Banerjee; Michelle M Le Beau; Richard A Larson; James M Allan; Kenan Onel
MDM2 SNP309 and TP53 Arg72Pro interact to alter therapy-related acute myeloid leukemia susceptibility.
Blood 2008;112(3):741-9.
2008: Charles G Mullighan; Christopher B Miller; Ina Radtke; Letha Phillips; James Dalton; Jing Ma; Deborah White; Timothy P Hughes; Michelle M Le Beau; Ching-Hon Pui; Mary Relling; Sheila A Shurtleff; James R Downing
BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros.
Nature 2008;453(7191):110-4.
2008: Kevin Shannon; Michelle M Le Beau
Cancer: hay in a haystack.
Nature 2008;451(7176):252-3.
2008: Gina Kirsammer; Sarah Jilani; Hui Liu; Elizabeth Davis; Sandeep Gurbuxani; Michelle M Le Beau; John D Crispino
Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome.
Blood 2008;111(2):767-75.
2007: Shuangli Mi; Jun Lu; Miao Sun; Zejuan Li; Hao Zhang; Mary Beth Neilly; Yungui Wang; Zhijian Qian; Jie Jin; Yanming Zhang; Stefan K Bohlander; Michelle M Le Beau; Richard A Larson; Todd R Golub; Janet D Rowley; Jianjun Chen
MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):19971-6.
2007: K R Ostler; Elizabeth M Davis; S L Payne; B B Gosalia; J Expósito-Céspedes; Michelle M Le Beau; Lucy A Godley
Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins.
Oncogene 2007;26(38):5553-63.
2007: Isabelle Lucas; Aparna Palakodeti; Yanwen Jiang; David J Young; Nan Jiang; Anthony A Fernald; Michelle M Le Beau
High-throughput mapping of origins of replication in human cells.
EMBO reports 2007;8(8):770-7.
2007: John M Joslin; Anthony A Fernald; Thelma R Tennant; Elizabeth M Davis; Scott C Kogan; John Anastasi; John D Crispino; Michelle M Le Beau
Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders.
Blood 2007;110(2):719-26.
2007: Anita Boyapati; Ming Yan; Luke Peterson; Joseph R Biggs; Michelle M Le Beau; Dong-Er Zhang
A leukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidy.
Blood 2007;109(9):3963-71.
2007: Harold J Olney; Michelle M Le Beau
Evaluation of recurring cytogenetic abnormalities in the treatment of myelodysplastic syndromes.
Leukemia research 2007;31(4):427-34.
2007: Ján Markus; Matthew T Garin; Juraj Bies; Naomi Galili; Azra Raza; Michael J Thirman; Michelle M Le Beau; Janet D Rowley; P Paul Liu; Linda Wolff
Methylation-independent silencing of the tumor suppressor INK4b (p15) by CBFbeta-SMMHC in acute myelogenous leukemia with inv(16).
Cancer research 2007;67(3):992-1000.
2007: Zeba N Singh; Dezheng Huo; John Anastasi; Sonali M Smith; Theodore Karrison; Michelle M Le Beau; Richard A Larson; James W Vardiman
Therapy-related myelodysplastic syndrome: morphologic subclassification may not be clinically relevant.
American journal of clinical pathology 2007;127(2):197-205.
2007: Mark A Lones; Nyla A Heerema; Michelle M Le Beau; Richard Sposto; Sherrie L Perkins; Marshall E Kadin; Carl R Kjeldsberg; Anna Meadows; Stuart E Siegel; Jonathan Buckley; Minnie Abromowitch; John H Kersey; Sharon Bergeron; Mitchell S Cairo; Warren G Sanger
Chromosome abnormalities in advanced stage lymphoblastic lymphoma of children and adolescents: a report from CCG-E08.
Cancer genetics and cytogenetics 2007;172(1):1-11.
2006: Mark A Lones; Nyla A Heerema; Michelle M Le Beau; Sherrie L Perkins; Marshall E Kadin; Carl R Kjeldsberg; Richard Sposto; Anna Meadows; Stuart E Siegel; Jonathan Buckley; Jonathan Lester Finlay; Minnie Abromowitch; Mitchell S Cairo; Warren G Sanger
Complex secondary chromosome abnormalities in advanced stage anaplastic large cell lymphoma of children and adolescents: a report from CCG-E08.
Cancer genetics and cytogenetics 2006;171(2):89-96.
2006: Karen Stephens; Molly Weaver; Kathleen A Leppig; Kyoko Maruyama; Peter D Emanuel; Michelle M Le Beau; Kevin Shannon
Interstitial uniparental isodisomy at clustered breakpoint intervals is a frequent mechanism of NF1 inactivation in myeloid malignancies.
Blood 2006;108(5):1684-9.
2006: Iris T Chan; Jeffery L Kutok; Ifor Williams; Sarah Cohen; Sandra Moore; Hirokazu Shigematsu; Timothy J Ley; Koichi Akashi; Michelle M Le Beau; D Gary Gilliland
Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease.
Blood 2006;108(5):1708-15.
2006: Miroslav Djokic; Michelle M Le Beau; Lode J Swinnen; Sonali M Smith; Charles M Rubin; John Anastasi; Katrin M Carlson
Post-transplant lymphoproliferative disorder subtypes correlate with different recurring chromosomal abnormalities.
Genes, chromosomes & cancer 2006;45(3):313-8.
2006: Thomas Sternsdorf; Vernon T Phan; Mei Lin Maunakea; Corinne B Ocampo; Jastinder Sohal; Angela Silletto; Francesco Galimi; Michelle M Le Beau; Ronald M Evans; Scott C Kogan
Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia.
Cancer cell 2006;9(2):81-94.
2006: Ya-Huei Kuo; Sean F. Landrette; Susan A Heilman; Paola N Perrat; Lisa Garrett; P Paul Liu; Michelle M Le Beau; Scott C Kogan; Lucio H Castilla
Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia.
Cancer cell 2006;9(1):57-68.
2005: Hui Luo; Qing Li; Julie O'Neal; Friederike Kreisel; Michelle M Le Beau; Michael H Tomasson
c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations.
Blood 2005;106(7):2452-61.
2005: Richard A Larson; Michelle M Le Beau
Therapy-related myeloid leukaemia: a model for leukemogenesis in humans.
Chemico-biological interactions 2005;153-154():187-95.
2005: Nicole P Curtiss; Jeannette Bonifas; Jennifer O Lauchle; Jason D Balkman; Christian P Kratz; Brooke M Emerling; Eric Green; Michelle M Le Beau; Kevin Shannon
Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22.
Genomics 2005;85(5):600-7.
2005: Partow Kebriaei; J Kline; Wendy Stock; Kristen Kasza; Michelle M Le Beau; Richard A Larson; Koen van Besien
Impact of disease burden at time of allogeneic stem cell transplantation in adults with acute myeloid leukemia and myelodysplastic syndromes.
Bone marrow transplantation 2005;35(10):965-70.
2005: Xiaxin Li; Michelle M Le Beau; Samantha L M Ciccone; Feng-Chun Yang; Brian Freie; Shi Chen; Jin Yuan; Ping Hong; Attilio Orazi; Laura S Haneline; D Wade Clapp
Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy.
Blood 2005;105(9):3465-71.
2005: Neal A Fischbach; Sophia Rozenfeld; Weifang Shen; Sylvia Fong; Daniel Chrobak; David Ginzinger; Scott C Kogan; Archana Radhakrishnan; Michelle M Le Beau; Corey Largman; H Jeffrey Lawrence
HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo.
Blood 2005;105(4):1456-66.
2004: Sherif S Farag; Amy S Ruppert; Krzysztof Mrózek; Andrew J Carroll; Mark J Pettenati; Michelle M Le Beau; Bercedis L Peterson; Bayard L Powell; Howard Ozer; Richard T Silver; Richard A Larson; Clara D Bloomfield
Prognostic significance of additional cytogenetic abnormalities in newly diagnosed patients with Philadelphia chromosome-positive chronic myelogenous leukemia treated with interferon-alpha: a Cancer and Leukemia Group B study.
International journal of oncology 2004;25(1):143-51.
2004: Frank Rosenbauer; Katharina Wagner; Jeffery L Kutok; Hiromi Iwasaki; Michelle M Le Beau; Yutaka Okuno; Koichi Akashi; Steven Fiering; Daniel G Tenen
Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.
Nature genetics 2004;36(6):624-30.
2004: Doan T Le; Namie Kong; Yuan Zhu; Jennifer O Lauchle; Abigail Aiyigari; Benjamin S Braun; Endi Wang; Scott C Kogan; Michelle M Le Beau; Luis F Parada; Kevin Shannon
Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder.
Blood 2004;103(11):4243-50.
2004: Partow Kebriaei; Jane N Winter; Ginna G Laport; Michelle M Le Beau; Gordon Dewald; Richard A Larson
Multiple unrelated clonal abnormalities in host bone marrow cells after allogeneic stem cell transplantation.
Leukemia research 2004;28(5):537-40.
2004: Mignon L Loh; Shashaank Vattikuti; Suzanne Schubbert; Melissa G Reynolds; Elaine Carlson; Kenneth Lieuw; Jennifer W Cheng; Connie M Lee; David Stokoe; Jeannette Bonifas; Nicole P Curtiss; Jason Gotlib; Soheil Meshinchi; Michelle M Le Beau; Peter D Emanuel; Kevin Shannon
Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis.
Blood 2004;103(6):2325-31.
2004: Mark A Lones; Warren G Sanger; Michelle M Le Beau; Nyla A Heerema; Richard Sposto; Sherrie L Perkins; Jonathan Buckley; Marshall E Kadin; Carl R Kjeldsberg; Anna Meadows; Stuart E Siegel; Jonathan Lester Finlay; Sharon Bergeron; Mitchell S Cairo
Chromosome abnormalities may correlate with prognosis in Burkitt/Burkitt-like lymphomas of children and adolescents: a report from Children's Cancer Group Study CCG-E08.
Journal of pediatric hematology/oncology 2004;26(3):169-78.
2004: Lucy E Side; Nicole P Curtiss; Kathryn Teel; Christian P Kratz; Pauline W Wang; Richard A Larson; Michelle M Le Beau; Kevin Shannon
RAS, FLT3, and TP53 mutations in therapy-related myeloid malignancies with abnormalities of chromosomes 5 and 7.
Genes, chromosomes & cancer 2004;39(3):217-23.
2004: Benjamin S Braun; David A Tuveson; Namie Kong; Doan T Le; Scott C Kogan; Jacob Rozmus; Michelle M Le Beau; Tyler Jacks; Kevin Shannon
Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(2):597-602.
2004: Aparna Palakodeti; Yu Han; Yanwen Jiang; Michelle M Le Beau
The role of late/slow replication of the FRA16D in common fragile site induction.
Genes, chromosomes & cancer 2004;39(1):71-6.
2003: Ann M Ranger; Jiping Zha; Hisashi Harada; Sandeep Robert Datta; Nika N Danial; Andrew P Gilmore; Jeffery L Kutok; Michelle M Le Beau; Michael E Greenberg; Stanley J Korsmeyer
Bad-deficient mice develop diffuse large B cell lymphoma.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9324-9.
2003: Michelle M Le Beau; Elizabeth M Davis; Bhumi Patel; Vernon T Phan; Jastinder Sohal; Scott C Kogan
Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice identify cooperating events and genetic pathways to acute promyelocytic leukemia.
Blood 2003;102(3):1072-4.
2003: Vernon T Phan; David B Shultz; Bao-Tran H Truong; Timothy J Blake; Anna L Brown; Thomas J Gonda; Michelle M Le Beau; Scott C Kogan
Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation.
Molecular and cellular biology 2003;23(13):4573-85.
2003: M William Lensch; Marc Tischkowitz; Tracy A Christianson; Carol A Reifsteck; S Ashley Speckhart; Petra Jakobs; Michael O'Dwyer; Susan B Olson; Michelle M Le Beau; Shirley V Hodgson; Christopher G Mathew; Richard A Larson; Grover C Bagby
Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia.
Blood 2003;102(1):7-16.
2003: Sonali M Smith; Michelle M Le Beau; Dezheng Huo; Theodore Karrison; Ronald Sobecks; John Anastasi; James W Vardiman; Janet D Rowley; Richard A Larson
Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series.
Blood 2003;102(1):43-52.
2003: Jastinder Sohal; Vernon T Phan; Philip V Chan; Elizabeth M Davis; Bhumi Patel; Louise M Kelly; Tinya J Abrams; Anne-Marie O'Farrell; D Gary Gilliland; Michelle M Le Beau; Scott C Kogan
A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657.
Blood 2003;101(8):3188-97.
2003: Keri Fair; Michelle M Le Beau
Characterization of translocations in human cancer.
Methods in molecular biology (Clifton, N.J.) 2003;222():327-37.
2002: Zhijian Qian; Anthony A Fernald; Lucy A Godley; Richard A Larson; Michelle M Le Beau
Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):14925-30.
2002: Alessandro Gozzetti; Elizabeth M Davis; Rafael Espinosa; Anthony A Fernald; John Anastasi; Michelle M Le Beau
Identification of novel cryptic translocations involving IGH in B-cell non-Hodgkin's lymphomas.
Cancer research 2002;62(19):5523-7.
2002: Carla F. Kim; Michael L Sikes; Ruth Sullivan; Leslie Erskine Huye; Michelle M Le Beau; David B Roth; Olga K Mirzoeva; Eugene M Oltz; John H J Petrini
Cancer predisposition and hematopoietic failure in Rad50(S/S) mice.
Genes & development 2002;16(17):2237-51.
2002: Joshua Wechsler; Marianne Greene; A MICHAEL MCDEVITT; John Anastasi; Judith E Karp; Michelle M Le Beau; John D Crispino
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome.
Nature genetics 2002;32(1):148-52.
2002: Brooke M Emerling; Jeannette Bonifas; Christian P Kratz; Shane Donovan; Brigit R Taylor; Eric Green; Michelle M Le Beau; Kevin Shannon
MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia.
Oncogene 2002;21(31):4849-54.
2002: Shantel Corbin; Mary E Neilly; Rafael Espinosa; Elizabeth M Davis; Timothy W McKeithan; Michelle M Le Beau
Identification of unstable sequences within the common fragile site at 3p14.2: implications for the mechanism of deletions within fragile histidine triad gene/common fragile site at 3p14.2 in tumors.
Cancer research 2002;62(12):3477-84.
2002: Yuko Sato; Tohru Izumi; Hirakazu Kanamori; Elizabeth M Davis; Yasusada Miura; Richard A Larson; Michelle M Le Beau; Keiya Ozawa; Janet D Rowley
t(1;3)(p36;p21) is a recurring therapy-related translocation.
Genes, chromosomes & cancer 2002;34(2):186-92.
2002: Mark K Abe; Matthew P Saelzler; Rafael Espinosa; Kristopher T Kahle; Marc B Hershenson; Michelle M Le Beau; Marsha Rich Rosner
ERK8, a new member of the mitogen-activated protein kinase family.
The Journal of biological chemistry 2002;277(19):16733-43.
2002: Michelle M Le Beau; Sheila Bitts; Elizabeth M Davis; Scott C Kogan
Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice parallel human acute promyelocytic leukemia.
Blood 2002;99(8):2985-91.
2002: Steven T Kosak; Jane A Skok; Kay L Medina; Roy Riblet; Michelle M Le Beau; Amanda G Fisher; Harinder Singh
Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development.
Science (New York, N.Y.) 2002;296(5565):158-62.
2002: Yanming Zhang; Pamela L Strissel; Reiner Strick; Jianjun Chen; Giuseppina Nucifora; Michelle M Le Beau; Richard A Larson; Janet D Rowley
Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3070-5.
2002: Christian P Kratz; Brooke M Emerling; Jeannette Bonifas; Winfred Wang; Eric Green; Michelle M Le Beau; Kevin Shannon
Genomic structure of the PIK3CG gene on chromosome band 7q22 and evaluation as a candidate myeloid tumor suppressor.
Blood 2002;99(1):372-4.
2001: Christian P Kratz; Brooke M Emerling; Shane Donovan; M Laig-Webster; Brigit R Taylor; P Thompson; S Jensen; A Banerjee; Jeannette Bonifas; W Makalowski; Eric Green; Michelle M Le Beau; Kevin Shannon
Candidate gene isolation and comparative analysis of a commonly deleted segment of 7q22 implicated in myeloid malignancies.
Genomics 2001;77(3):171-80.
2001: Harold J Olney; Michelle M Le Beau
The cytogenetics of myelodysplastic syndromes.
Best practice & research. Clinical haematology 2001;14(3):479-95.
2001: Dolors Sanchez-Izquierdo; Reiner Siebert; Lana Harder; Isabel Marugan; A Gozzetti; Helen Price; Stefan Gesk; J M Hernandez-Rivas; Isabel Benet; Francesc Solé; Takashi Sonoki; Michelle M Le Beau; Brigitte Schlegelberger; Martin J S Dyer; Javier Garcia-Conde; Jose A Martinez-Climent
Detection of translocations affecting the BCL6 locus in B cell non-Hodgkin's lymphoma by interphase fluorescence in situ hybridization.
Leukemia 2001;15(9):1475-84.
2001: Y Sato; H Kobayashi; Y Suto; Harold J Olney; Elizabeth M Davis; H G Super; Rafael Espinosa; Michelle M Le Beau; Janet D Rowley
Chromosomal instability in chromosome band 12p13: multiple breaks leading to complex rearrangements including cytogenetically undetectable sub-clones.
Leukemia 2001;15(8):1193-202.
2001: F Lai; Lucy A Godley; J Joslin; Anthony A Fernald; J Liu; Rafael Espinosa; N Zhao; L Pamintuan; B G Till; Richard A Larson; Zhijian Qian; Michelle M Le Beau
Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q).
Genomics 2001;71(2):235-45.
2001: Archontoula Stoffel; Michelle M Le Beau
The API2/MALT1 fusion product may lead to germinal center B cell lymphomas by suppression of apoptosis.
Human heredity 2001;51(1-2):1-7.
2000: F Lai; Lucy A Godley; Anthony A Fernald; Brian J Orelli; L Pamintuan; N Zhao; Michelle M Le Beau
cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins.
Genomics 2000;70(1):123-30.
2000: Alessandro Gozzetti; Michelle M Le Beau
Fluorescence in situ hybridization: uses and limitations.
Seminars in hematology 2000;37(4):320-33.
2000: PW Wang; JD Eisenbart; Rafael Espinosa; Elizabeth M Davis; Richard A Larson; Michelle M Le Beau
Refinement of the smallest commonly deleted segment of chromosome 20 in malignant myeloid diseases and development of a PAC-based physical and transcription map.
Genomics 2000;67(1):28-39.
2000: F Lai; Brian J Orelli; B G Till; Lucy A Godley; Anthony A Fernald; L Pamintuan; Michelle M Le Beau
Molecular characterization of KLHL3, a human homologue of the Drosophila kelch gene.
Genomics 2000;66(1):65-75.
2000: F Lai; Anthony A Fernald; N Zhao; Michelle M Le Beau
cDNA cloning, expression pattern, genomic structure and chromosomal location of RAB6KIFL, a human kinesin-like gene.
Gene 2000;248(1-2):117-25.
2000: Katrin M Carlson; C Vignon; Stefan K Bohlander; Jose A Martinez-Climent; Michelle M Le Beau; Janet D Rowley
Identification and molecular characterization of CALM/AF10fusion products in T cell acute lymphoblastic leukemia and acute myeloid leukemia.
Leukemia 2000;14(1):100-4.
2000: U Korthäuer; Wolfram Nagel; Elizabeth M Davis; Michelle M Le Beau; R S Menon; E O Mitchell; C A Kozak; Waldemar Kolanus; Jeffrey A Bluestone
Anergic T lymphocytes selectively express an integrin regulatory protein of the cytohesin family.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):308-18.
1999: Lucy A Godley; F Lai; J Liu; N Zhao; Michelle M Le Beau
TTID: A novel gene at 5q31 encoding a protein with titin-like features.
Genomics 1999;60(2):226-33.
1999: PW Wang; JD Eisenbart; S P Cordes; G S Barsh; M Stoffel; Michelle M Le Beau
Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias.
Genomics 1999;59(3):275-81.
1999: Richard A Larson; Y Wang; M Banerjee; J Wiemels; C Hartford; Michelle M Le Beau; M T Smith
Prevalence of the inactivating 609C-->T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia.
Blood 1999;94(2):803-7.
1999: Ronald Sobecks; Michelle M Le Beau; John Anastasi; Stephanie F Williams
Myelodysplasia and acute leukemia following high-dose chemotherapy and autologous bone marrow or peripheral blood stem cell transplantation.
Bone marrow transplantation 1999;23(11):1161-5.
1999: Meir Wetzler; Richard K Dodge; Krzysztof Mrózek; Andrew J Carroll; Ramana Tantravahi; A W Block; Mark J Pettenati; Michelle M Le Beau; Stanley R Frankel; Carleton C Stewart; Ted P Szatrowski; Charles Alan Schiffer; Richard A Larson; Clara D Bloomfield
Prospective karyotype analysis in adult acute lymphoblastic leukemia: the cancer and leukemia Group B experience.
Blood 1999;93(11):3983-93.
1999: N Mahgoub; Brigit R Taylor; Michelle M Le Beau; M Gratiot; K M Carlson; SK Atwater; Tyler Jacks; Kevin Shannon
Myeloid malignancies induced by alkylating agents in Nf1 mice.
Blood 1999;93(11):3617-23.
1999: Archontoula Stoffel; Pulivarthi H Rao; Diane Louie; K Krauter; D N Liebowitz; H Koeppen; Michelle M Le Beau; Raju S K Chaganti
Chromosome 18 breakpoint in t(11;18)(q21;q21) translocation associated with MALT lymphoma is proximal to BCL2 and distal to DCC.
Genes, chromosomes & cancer 1999;24(2):156-9.
1998: N Zhao; F Lai; Anthony A Fernald; JD Eisenbart; Rafael Espinosa; PW Wang; Michelle M Le Beau
Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias.
Genomics 1998;53(2):184-90.
1998: Diane Roulston; Rafael Espinosa; Giuseppina Nucifora; Richard A Larson; Michelle M Le Beau; Janet D Rowley
CBFA2(AML1) translocations with novel partner chromosomes in myeloid leukemias: association with prior therapy.
Blood 1998;92(8):2879-85.
1998: Minggui Chen; HY She; Elizabeth M Davis; C M Spicer; L Kim; Ruibao Ren; Michelle M Le Beau; Wenhui Li
Identification of Nck family genes, chromosomal localization, expression, and signaling specificity.
The Journal of biological chemistry 1998;273(39):25171-8.
1998: Hue H Luu; Gregory P Zagaja; Zita Dubauskas; S L Chen; R C Smith; K Watabe; Y Ichikawa; T Ichikawa; Elizabeth M Davis; Michelle M Le Beau; Carrie W Rinker-Schaeffer
Identification of a novel metastasis-suppressor region on human chromosome 12.
Cancer research 1998;58(16):3561-5.
1998: ST Ong; Michelle M Le Beau
Chromosomal abnormalities and molecular genetics of non-Hodgkin's lymphoma.
Seminars in oncology 1998;25(4):447-60.
1998: H Furuta; Yukio Horikawa; Naoko Iwasaki; Manami Hara; L Sussel; Michelle M Le Beau; Elizabeth M Davis; Makiko Ogata; Yasuhiko Iwamoto; Michael S German; Graeme I Bell
Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese.
Diabetes 1998;47(8):1356-8.
1998: R J Allen; Stephen Dale Smith; R L Moldwin; M M Lu; L Giordano; C Vignon; Y Suto; AM Harden; Ronald Tomek; T Veldman; Thomas Ried; Richard A Larson; Michelle M Le Beau; Janet D Rowley; Nancy J Zeleznik-Le
Establishment and characterization of a megakaryoblast cell line with amplification of MLL.
Leukemia 1998;12(7):1119-27.
1998: James P Carney; richard s maser; HA Olivares; Elizabeth M Davis; Michelle M Le Beau; John R Yates; L Hays; William F Morgan; John H J Petrini
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.
Cell 1998;93(3):477-86.
1998: Michelle M Le Beau; Harry A Drabkin; Thomas W Glover; Robert M Gemmill; Feyruz V Rassool; Timothy W McKeithan; David I Smith
An FHIT tumor suppressor gene?
Genes, chromosomes & cancer 1998;21(4):281-9.
1998: Michelle M Le Beau; Feyruz V Rassool; Mary E Neilly; Rafael Espinosa; Thomas W Glover; David I Smith; Timothy W McKeithan
Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction.
Human molecular genetics 1998;7(4):755-61.
1998: PW Wang; K Iannantuoni; Elizabeth M Davis; Rafael Espinosa; M Stoffel; Michelle M Le Beau
Refinement of the commonly deleted segment in myeloid leukemias with a del(20q).
Genes, chromosomes & cancer 1998;21(2):75-81.
1997: Y Sato; Stefan K Bohlander; H Kobayashi; SC Reshmi; Y Suto; Elizabeth M Davis; Rafael Espinosa; R Hoopes; Kate T Montgomery; Raju Kucherlapati; Michelle M Le Beau; Janet D Rowley
Heterogeneity in the breakpoints in balanced rearrangements involving band 12p13 in hematologic malignancies identified by fluorescence in situ hybridization: TEL (ETV6 ) is involved in only one half.
Blood 1997;90(12):4886-93.
1997: P Wang; R T Spielberger; M Thangavelu; N Zhao; Elizabeth M Davis; K Iannantuoni; Richard A Larson; Michelle M Le Beau
dic(5;17): a recurring abnormality in malignant myeloid disorders associated with mutations of TP53.
Genes, chromosomes & cancer 1997;20(3):282-91.
1997: ST Ong; Kwun M Fong; SA Bader; John D Minna; Michelle M Le Beau; Timothy W McKeithan; Feyruz V Rassool
Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines.
Genes, chromosomes & cancer 1997;20(1):16-23.
1997: Y Sato; Stefan K Bohlander; H Kobayashi; Y Suto; Elizabeth M Davis; Rafael Espinosa; Michelle M Le Beau; Janet D Rowley
Identification of pericentric inversion 12, inv(12)(p13.1q11), by fluorescence in situ hybridization in a patient with acute myeloid leukemia (AML-M6).
Cancer genetics and cytogenetics 1997;97(2):157-60.
1997: N Zhao; Archontoula Stoffel; PW Wang; JD Eisenbart; Rafael Espinosa; Richard A Larson; Michelle M Le Beau
Molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases to 1-1.5 Mb and preparation of a PAC-based physical map.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6948-53.
1997: Riccardo Levi-Setti; JM Chabala; Konstantin L Gavrilov; Rafael Espinosa; Michelle M Le Beau
Imaging of BrdU-labeled human metaphase chromosomes with a high resolution scanning ion microprobe.
Microscopy research and technique 1997;36(4):301-12.
1997: R Espinosa; Michelle M Le Beau
Gene mapping by FISH.
Methods in molecular biology (Clifton, N.J.) 1997;68():53-76.
1997: Wendy Stock; Carol A Westbrook; B Peterson; D C Arthur; Ted P Szatrowski; Richard T Silver; Dorie A Sher; Ding Wu; Michelle M Le Beau; Charles Alan Schiffer; Clara D Bloomfield
Value of molecular monitoring during the treatment of chronic myeloid leukemia: a Cancer and Leukemia Group B study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(1):26-36.
1996: K Yamagata; Naohisa Oda; Pamela J Kaisaki; Stephan Menzel; H Furuta; Martine Vaxillaire; L Southam; R D Cox; G Mark Lathrop; V V Boriraj; X Chen; Nancy J Cox; Y Oda; H Yano; Michelle M Le Beau; S Yamada; H Nishigori; J Takeda; SS Fajans; Andrew T Hattersley; Naoko Iwasaki; Torben Hansen; Oluf Pedersen; Kenneth S Polonsky; Graeme I Bell
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
Nature 1996;384(6608):455-8.
1996: W A Chutkow; M C Simon; Michelle M Le Beau; Charles F Burant
Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels.
Diabetes 1996;45(10):1439-45.
1996: Michelle M Le Beau; Rafael Espinosa; Elizabeth M Davis; JD Eisenbart; Richard A Larson; Eric Green
Cytogenetic and molecular delineation of a region of chromosome 7 commonly deleted in malignant myeloid diseases.
Blood 1996;88(6):1930-5.
1996: H Furuta; S Nishi; Michelle M Le Beau; A A Fernald; H Yano; Graeme I Bell
Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization.
Genomics 1996;36(1):206-9.
1996: Feyruz V Rassool; Michelle M Le Beau; M L Shen; M E Neilly; Rafael Espinosa; ST Ong; F Boldog; Harry A Drabkin; R McCarroll; Timothy W McKeithan
Direct cloning of DNA sequences from the common fragile site region at chromosome band 3p14.2.
Genomics 1996;35(1):109-17.
1996: Riccardo Levi-Setti; JM Chabala; Konstantin L Gavrilov; Rafael Espinosa; Michelle M Le Beau
Advances in high resolution SIMS studies of BrdU-labelled human metaphase chromosomes.
Cellular and molecular biology (Noisy-le-Grand, France) 1996;42(3):301-24.
1996: John Anastasi; J Feng; J I Dickstein; Michelle M Le Beau; C M Rubin; Richard A Larson; Janet D Rowley; James W Vardiman
Lineage involvement by BCR/ABL in Ph+ lymphoblastic leukemias: chronic myelogenous leukemia presenting in lymphoid blast vs Ph+ acute lymphoblastic leukemia.
Leukemia 1996;10(5):795-802.
1996: M Stoffel; Michelle M Le Beau; Rafael Espinosa; S F Bohlander; D Le Paslier; D Cohen; Kun-san Xiang; Nancy J Cox; SS Fajans; Graeme I Bell
A yeast artificial chromosome-based map of the region of chromosome 20 containing the diabetes-susceptibility gene, MODY1, and a myeloid leukemia related gene.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):3937-41.
1996: Olufunmilayo I Olopade; Diane Roulston; T Baker; S Narvid; Michelle M Le Beau; E J Freireich; Richard A Larson; HM Golomb
Familial myeloid leukemia associated with loss of the long arm of chromosome 5.
Leukemia 1996;10(4):669-74.
1995: J A Martinez-Climent; Rafael Espinosa; M J Thirman; Michelle M Le Beau; Janet D Rowley
Abnormalities of chromosome band 11q23 and the MLL gene in pediatric myelomonocytic and monoblastic leukemias. Identification of the t(9;11) as an indicator of long survival.
Journal of pediatric hematology/oncology 1995;17(4):277-83.
1995: J Takeda; Rafael Espinosa; S Eng; Michelle M Le Beau; Graeme I Bell
Chromosomal assignment and tissue distribution of novel expressed sequence tags from a human pancreatic islet cDNA library.
Genomics 1995;29(1):276-81.
1995: Martin Dreyling; Stefan K Bohlander; Michelle M Le Beau; Olufunmilayo I Olopade
Refined mapping of genomic rearrangements involving the short arm of chromosome 9 in acute lymphoblastic leukemias and other hematologic malignancies.
Blood 1995;86(5):1931-8.
1995: Y Sato; Y Suto; J Pietenpol; Todd R Golub; D Gary Gilliland; Elizabeth M Davis; Michelle M Le Beau; J M Roberts; Bert Vogelstein; Janet D Rowley
TEL and KIP1 define the smallest region of deletions on 12p13 in hematopoietic malignancies.
Blood 1995;86(4):1525-33.
1995: M Stoffel; A A Fernald; Michelle M Le Beau; Graeme I Bell
Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization.
Genomics 1995;28(3):607-9.
1995: Martin Dreyling; H Kobayashi; Olufunmilayo I Olopade; Michelle M Le Beau; Janet D Rowley; Stefan K Bohlander
Detection of 9p deletions in leukemia cell lines by interphase fluorescence in situ hybridization with YAC-derived probes.
Cancer genetics and cytogenetics 1995;83(1):46-55.
1995: J A Martinez-Climent; M J Thirman; Rafael Espinosa; Michelle M Le Beau; Janet D Rowley
Detection of 11q23/MLL rearrangements in infant leukemias with fluorescence in situ hybridization and molecular analysis.
Leukemia 1995;9(8):1299-304.
1995: Olufunmilayo I Olopade; H M Pomykala; F Hagos; L W Sveen; Rafael Espinosa; Martin Dreyling; S Gursky; Walter M Stadler; Michelle M Le Beau; Stefan K Bohlander
Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6489-93.
1995: M Stoffel; R Stein; C V Wright; Rafael Espinosa; Michelle M Le Beau; Graeme I Bell
Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1.
Genomics 1995;28(1):125-6.
1995: M Raafat El-Maghrabi; A J Lange; W Jiang; K Yamagata; M Stoffel; J Takeda; A A Fernald; Michelle M Le Beau; Graeme I Bell; L Baker
Human fructose-1,6-bisphosphatase gene (FBP1): exon-intron organization, localization to chromosome bands 9q22.2-q22.3, and mutation screening in subjects with fructose-1,6-bisphosphatase deficiency.
Genomics 1995;27(3):520-5.
1995: Meei-Ling Tsaur; Stephan Menzel; F P Lai; Rafael Espinosa; Patrick Concannon; Richard S Spielman; Craig L Hanis; Nancy J Cox; Michelle M Le Beau; Michael S German
Isolation of a cDNA clone encoding a KATP channel-like protein expressed in insulin-secreting cells, localization of the human gene to chromosome band 21q22.1, and linkage studies with NIDDM.
Diabetes 1995;44(5):592-6.
1995: J Takeda; A A Fernald; K Yamagata; Michelle M Le Beau; Graeme I Bell
Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization.
Genomics 1995;26(3):638-9.
1995: John Anastasi; J Feng; Michelle M Le Beau; Richard A Larson; Janet D Rowley; James W Vardiman
The relationship between secondary chromosomal abnormalities and blast transformation in chronic myelogenous leukemia.
Leukemia 1995;9(4):628-33.
1995: L P Joventino; W Stock; N J Lane; K M Daly; R Mick; Michelle M Le Beau; Richard A Larson
Certain HLA antigens are associated with specific morphologic and cytogenetic subsets of acute myeloid leukemia.
Leukemia 1995;9(3):433-9.
1995: Michelle M Le Beau; C Song; Elizabeth M Davis; R A Hiipakka; John M Kokontis; Shutsung Liao
Assignment of the human ubiquitous receptor gene (UNR) to 19q13.3 using fluorescence in situ hybridization.
Genomics 1995;26(1):166-8.
1995: J A Martinez-Climent; N J Lane; C M Rubin; E Morgan; H S Johnstone; R Mick; S B Murphy; James W Vardiman; Richard A Larson; Michelle M Le Beau
Clinical and prognostic significance of chromosomal abnormalities in childhood acute myeloid leukemia de novo.
Leukemia 1995;9(1):95-101.
1995: Feyruz V Rassool; M E Neilly; K L McGuire; Timothy W McKeithan; Michelle M Le Beau
Localization of the Chinese hamster MHC locus to chromosome 1q17-->q18 by fluorescence in situ hybridization.
Cytogenetics and cell genetics 1995;71(1):62-3.
1995: E M Jones; A Fernald; Graeme I Bell; Michelle M Le Beau
Assignment of SLC6A9 to human chromosome band 1p33 by in situ hybridization.
Cytogenetics and cell genetics 1995;71(3):211.
1994: H Kobayashi; K T Montgomery; Stefan K Bohlander; Chaker N Adra; B L Lim; Raju Kucherlapati; H Donis-Keller; M S Holt; Michelle M Le Beau; Janet D Rowley
Fluorescence in situ hybridization mapping of translocations and deletions involving the short arm of human chromosome 12 in malignant hematologic diseases.
Blood 1994;84(10):3473-82.
1994: Rafael Espinosa; T Funahashi; C Hadjiagapiou; Michelle M Le Beau; Nicholas O Davidson
Assignment of the gene encoding the human apolipoprotein B mRNA editing enzyme (APOBEC1) to chromosome 12p13.1.
Genomics 1994;24(2):414-5.
1994: Michael S German; J Wang; A A Fernald; Rafael Espinosa; Michelle M Le Beau; G I Bell
Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13.
Genomics 1994;24(2):403-4.
1994: M Stoffel; Rafael Espinosa; J B Trabb; Michelle M Le Beau; Graeme I Bell
Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical, and genetic map of chromosome 7.
Genomics 1994;23(3):697-9.
1994: P A Downie; Nicholas J Vogelzang; R L Moldwin; Michelle M Le Beau; John Anastasi; R J Allen; S E Myers; Richard A Larson; Stephen Dale Smith
Establishment of a leukemia cell line with i(12p) from a patient with a mediastinal germ cell tumor and acute lymphoblastic leukemia.
Cancer research 1994;54(18):4999-5004.
1994: E M Jones; Stephan Menzel; Rafael Espinosa; Michelle M Le Beau; Graeme I Bell; J Takeda
Localization of the gene encoding a neutral amino acid transporter-like protein to human chromosome band 19q13.3 and characterization of a simple sequence repeat DNA polymorphism.
Genomics 1994;23(2):490-1.
1994: H Yano; Louis H Philipson; J L Kugler; Y Tokuyama; Elizabeth M Davis; Michelle M Le Beau; Deborah J Nelson; Graeme I Bell; J Takeda
Alternative splicing of human inwardly rectifying K+ channel ROMK1 mRNA.
Molecular pharmacology 1994;45(5):854-60.
1994: M Stoffel; Rafael Espinosa; K L Powell; Louis H Philipson; Michelle M Le Beau; Graeme I Bell
Human G-protein-coupled inwardly rectifying potassium channel (GIRK1) gene (KCNJ3): localization to chromosome 2 and identification of a simple tandem repeat polymorphism.
Genomics 1994;21(1):254-6.
1994: Stephan Menzel; M Stoffel; Rafael Espinosa; A A Fernald; Michelle M Le Beau; Graeme I Bell
Localization of the glucagon receptor gene to human chromosome band 17q25.
Genomics 1994;20(2):327-8.
1994: K Yasuda; Rafael Espinosa; J Takeda; Michelle M Le Beau; Graeme I Bell
Localization of the kappa opioid receptor gene to human chromosome band 8q11.2.
Genomics 1994;19(3):596-7.
1994: Stefan K Bohlander; Rafael Espinosa; A A Fernald; Janet D Rowley; Michelle M Le Beau; M O Díaz
Sequence-independent amplification and labeling of yeast artificial chromosomes for fluorescence in situ hybridization.
Cytogenetics and cell genetics 1994;65(1-2):108-10.
1994: Michelle M Le Beau; L A Carver; Rafael Espinosa; Jennifer Schmidt; Christopher A Bradfield
Chromosomal localization of the human AHR locus encoding the structural gene for the Ah receptor to 7p21-->p15.
Cytogenetics and cell genetics 1994;66(3):172-6.
1994: Carol A Westbrook; Michelle M Le Beau; W L Neuman; M Keinanen; L H Yamaoka; M C Speer; Rafael Espinosa; Y Nakamura; R Williamson; M Mullan
Physical and genetic map of 5q31: use of fluorescence in situ hybridization data to identify errors in the CEPH database. Centre d'Etude de Polymorphisme Humain.
Cytogenetics and cell genetics 1994;67(2):86-93.
1993: H J Super; N R McCabe; M J Thirman; Richard A Larson; Michelle M Le Beau; J Pedersen-Bjergaard; P Philip; Manuel O Diaz; Janet D Rowley
Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase II.
Blood 1993;82(12):3705-11.
1993: M Lehto; Kun-san Xiang; M Stoffel; Rafael Espinosa; L C Groop; Michelle M Le Beau; Graeme I Bell
Human hexokinase II: localization of the polymorphic gene to chromosome 2.
Diabetologia 1993;36(12):1299-302.
1993: Diane Roulston; Rafael Espinosa; M Stoffel; Graeme I Bell; Michelle M Le Beau
Molecular genetics of myeloid leukemia: identification of the commonly deleted segment of chromosome 20.
Blood 1993;82(11):3424-9.
1993: H Kobayashi; Rafael Espinosa; A A Fernald; C Begy; Manuel O Diaz; Michelle M Le Beau; Janet D Rowley
Analysis of deletions of the long arm of chromosome 11 in hematologic malignancies with fluorescence in situ hybridization.
Genes, chromosomes & cancer 1993;8(4):246-52.
1993: K Yasuda; Rafael Espinosa; Elizabeth M Davis; Michelle M Le Beau; Graeme I Bell
Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2.
Genomics 1993;17(3):785-6.
1993: M Stoffel; Rafael Espinosa; Michelle M Le Beau; Graeme I Bell
Human glucagon-like peptide-1 receptor gene. Localization to chromosome band 6p21 by fluorescence in situ hybridization and linkage of a highly polymorphic simple tandem repeat DNA polymorphism to other markers on chromosome 6.
Diabetes 1993;42(8):1215-8.
1993: H Kobayashi; Rafael Espinosa; M J Thirman; A A Fernald; Kevin Shannon; Manuel O Diaz; Michelle M Le Beau; Janet D Rowley
Do terminal deletions of 11q23 exist? Identification of undetected translocations with fluorescence in situ hybridization.
Genes, chromosomes & cancer 1993;7(4):204-8.
1993: A N Lorenzana; N R McCabe; W R Goodell; L Q Zhang; D Miley; Michelle M Le Beau; S Goldman; Stephen Dale Smith
Characterization of a CD34+ cell line established from a child with large cell cutaneous lymphoma.
Cancer 1993;72(3):931-7.
1993: H Kobayashi; Rafael Espinosa; M J Thirman; H J Gill; A A Fernald; Manuel O Diaz; Michelle M Le Beau; Janet D Rowley
Heterogeneity of breakpoints of 11q23 rearrangements in hematologic malignancies identified with fluorescence in situ hybridization.
Blood 1993;82(2):547-51.
1993: Michelle M Le Beau; Rafael Espinosa; W L Neuman; W Stock; Diane Roulston; Richard A Larson; M Keinanen; Carol A Westbrook
Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(12):5484-8.
1993: Beverly W Baron; Giuseppina Nucifora; N McCabe; Rafael Espinosa; Michelle M Le Beau; Timothy W McKeithan
Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5262-6.
1993: H Kobayashi; Rafael Espinosa; M J Thirman; Elizabeth M Davis; Manuel O Diaz; Michelle M Le Beau; Janet D Rowley
Variability of 11q23 rearrangements in hematopoietic cell lines identified with fluorescence in situ hybridization.
Blood 1993;81(11):3027-33.
1993: J P Sanford; Sheila N J Sait; L Pan; Norma J Nowak; H J Gill; Michelle M Le Beau; Manuel O Diaz; B Zabel; TB Shows
Characterization of two 11q23.3-11q24 deletions and mapping of associated anonymous DNA markers.
Genes, chromosomes & cancer 1993;7(2):67-73.
1993: M Stoffel; Rafael Espinosa; Susanna R Keller; G E Lienhard; Michelle M Le Beau; Graeme I Bell
Human insulin receptor substrate-1 gene (IRS1): chromosomal localization to 2q35-q36.1 and identification of a simple tandem repeat DNA polymorphism.
Diabetologia 1993;36(4):335-7.
1993: John Anastasi; J Feng; Michelle M Le Beau; Richard A Larson; Janet D Rowley; James W Vardiman
Cytogenetic clonality in myelodysplastic syndromes studied with fluorescence in situ hybridization: lineage, response to growth factor therapy, and clone expansion.
Blood 1993;81(6):1580-5.
1993: R T Spielberger; J I Dickstein; Michelle M Le Beau; Richard A Larson; K M Daly; James W Vardiman; HM Golomb
Acute myeloid leukaemia following interferon-alfa treatment of hairy cell leukaemia.
British journal of haematology 1993;83(3):519-20.
1993: M Lehto; M Stoffel; L Groop; Rafael Espinosa; Michelle M Le Beau; Graeme I Bell
Assignment of the gene encoding glycogen synthase (GYS) to human chromosome 19, band q13.3.
Genomics 1993;15(2):460-1.
1993: Yoshihiko Yamada; M Stoffel; Rafael Espinosa; K S Xiang; M Seino; S Seino; Michelle M Le Beau; Graeme I Bell
Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms.
Genomics 1993;15(2):449-52.
1993: M Stoffel; Kun-san Xiang; Rafael Espinosa; Nancy J Cox; Michelle M Le Beau; Graeme I Bell
cDNA sequence and localization of polymorphic human cytosolic phosphoenolpyruvate carboxykinase gene (PCK1) to chromosome 20, band q13.31: PCK1 is not tightly linked to maturity-onset diabetes of the young.
Human molecular genetics 1993;2(1):1-4.
1993: Michelle M Le Beau; J Overhauser; R E Straub; G Silverman; T Conrad Gilliam; Jurg Ott; P O'Connell; U Francke; A Geurts van Kessel
Report of the first international workshop on human chromosome 18 mapping.
Cytogenetics and cell genetics 1993;63(2):78-96.
1993: W L Neuman; Carol A Westbrook; M Dixon; Rafael Espinosa; Y D Patel; Y Nakamura; B Weiffenbach; Michelle M Le Beau
Physical localization of 70 polymorphic markers to human chromosome 5 by fluorescence in situ hybridization.
Cytogenetics and cell genetics 1993;62(4):207-10.
1992: Olufunmilayo I Olopade; M Thangavelu; Richard A Larson; R Mick; A Kowal-Vern; H R Schumacher; Michelle M Le Beau; James W Vardiman; Janet D Rowley
Clinical, morphologic, and cytogenetic characteristics of 26 patients with acute erythroblastic leukemia.
Blood 1992;80(11):2873-82.
1992: W J Gradishar; Michelle M Le Beau; R O'Laughlin; James W Vardiman; Richard A Larson
Clinical and cytogenetic responses to granulocyte-macrophage colony-stimulating factor in therapy-related myelodysplasia.
Blood 1992;80(10):2463-70.
1992: D M White; D D Mikol; Rafael Espinosa; B Weimer; Michelle M Le Beau; Kari Stefansson
Structure and chromosomal localization of the human gene for a brain form of prostaglandin D2 synthase.
The Journal of biological chemistry 1992;267(32):23202-8.
1992: Michelle M Le Beau; C Ito; Patricia C Cogswell; Rafael Espinosa; A A Fernald; A S Baldwin
Chromosomal localization of the genes encoding the p50/p105 subunits of NF-kappa B (NFKB2) and the I kappa B/MAD-3 (NFKBI) inhibitor of NF-kappa B to 4q24 and 14q13, respectively.
Genomics 1992;14(2):529-31.
1992: Olufunmilayo I Olopade; Stefan K Bohlander; H Pomykala; Emin Maltepe; E Van Melle; Michelle M Le Beau; Manuel O Diaz
Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia.
Genomics 1992;14(2):437-43.
1992: M Thangavelu; L Snyder; John Anastasi; Michelle M Le Beau; M Kirven; Gastón R Picchio; Donald E Mosier; Janet D Rowley
Cytogenetic characterization of B-cell lymphomas from severe combined immunodeficiency disease mice given injections of lymphocytes from Epstein-Barr virus-positive donors.
Cancer research 1992;52(17):4678-81.
1992: Stefan K Bohlander; Rafael Espinosa; Michelle M Le Beau; Janet D Rowley; M O Díaz
A method for the rapid sequence-independent amplification of microdissected chromosomal material.
Genomics 1992;13(4):1322-4.
1992: S Seino; Yoshihiko Yamada; Rafael Espinosa; Michelle M Le Beau; Graeme I Bell
Assignment of the gene encoding the alpha 1 subunit of the neuroendocrine/brain-type calcium channel (CACNL1A2) to human chromosome 3, band p14.3.
Genomics 1992;13(4):1375-7.
1992: N Onodera; N R McCabe; James B Nachman; F L Johnson; Michelle M Le Beau; Janet D Rowley; C M Rubin
Hyperdiploidy arising from near-haploidy in childhood acute lymphoblastic leukemia.
Genes, chromosomes & cancer 1992;4(4):331-6.
1992: Feyruz V Rassool; Michelle M Le Beau; M E Neilly; E van Melle; Rafael Espinosa; Timothy W McKeithan
Increased genetic instability of the common fragile site at 3p14 after integration of exogenous DNA.
American journal of human genetics 1992;50(6):1243-51.
1992: John Anastasi; Michelle M Le Beau; James W Vardiman; A A Fernald; Richard A Larson; Janet D Rowley
Detection of trisomy 12 in chronic lymphocytic leukemia by fluorescence in situ hybridization to interphase cells: a simple and sensitive method.
Blood 1992;79(7):1796-801.
1992: A J Wagner; Michelle M Le Beau; Manuel O Diaz; Nissim Hay
Expression, regulation, and chromosomal localization of the Max gene.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):3111-5.
1992: W L Neuman; C M Rubin; R B Rios; Richard A Larson; Michelle M Le Beau; Janet D Rowley; James W Vardiman; Jeffrey L Schwartz; Rosann A Farber
Chromosomal loss and deletion are the most common mechanisms for loss of heterozygosity from chromosomes 5 and 7 in malignant myeloid disorders.
Blood 1992;79(6):1501-10.
1992: M Thangavelu; W L Neuman; Rafael Espinosa; Y Nakamura; Carol A Westbrook; Michelle M Le Beau
A physical and genetic linkage map of the distal long arm of human chromosome 5.
Cytogenetics and cell genetics 1992;59(1):27-30.
1992: W Stock; S C Chandrasekharappa; W L Neuman; Michelle M Le Beau; B H Brownstein; Carol A Westbrook
Characterization of yeast artificial chromosomes containing interleukin genes on human chromosome 5.
Cytogenetics and cell genetics 1992;61(4):263-5.
1992: Michelle M Le Beau
Deletions of chromosome 5 in malignant myeloid disorders.
Cancer surveys 1992;15():143-59.
1992: Anjana V Yeldandi; Y D Patel; M Liao; F T Kao; M Sambasiva Rao; Janardan K Reddy; Michelle M Le Beau
Localization of the human urate oxidase gene (UOX) to 1p22.
Cytogenetics and cell genetics 1992;61(2):121-2.
1992: W L Neuman; Michelle M Le Beau; Rosann A Farber; Valerie Lindgren; Carol A Westbrook
Somatic cell hybrid mapping of human chromosome band 5q31: a region important to hematopoiesis.
Cytogenetics and cell genetics 1992;61(2):103-6.
1992: J K Park; Michelle M Le Beau; TB Shows; Janet D Rowley; Manuel O Diaz
A complex genetic rearrangement in a t(10;14)(q24;q11) associated with T-cell acute lymphoblastic leukemia.
Genes, chromosomes & cancer 1992;4(1):32-40.
1991: C M Rubin; Michelle M Le Beau; R Mick; M A Bitter; James B Nachman; R Rudinsky; H J Appel; E Morgan; C R Suarez; H R Schumacher
Impact of chromosomal translocations on prognosis in childhood acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1991;9(12):2183-92.
1991: R C Burnett; J C David; A M Harden; Michelle M Le Beau; Janet D Rowley; Manuel O Diaz
The LCK gene is involved in the t(1;7)(p34;q34) in the T-cell acute lymphoblastic leukemia derived cell line, HSB-2.
Genes, chromosomes & cancer 1991;3(6):461-7.
1991: John P O'Bryan; R A Frye; Patricia C Cogswell; A Neubauer; B Kitch; C Prokop; R Espinosa; Michelle M Le Beau; Henry Earp; Edison Liu
axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.
Molecular and cellular biology 1991;11(10):5016-31.
1991: Carol A Westbrook; W L Neuman; J Hewitt; K K Kidd; Michelle M Le Beau; R Williamson
Report of the chromosome 5 workshop.
Genomics 1991;10(4):1105-9.
1991: Feyruz V Rassool; Timothy W McKeithan; M E Neilly; E van Melle; Rafael Espinosa; Michelle M Le Beau
Preferential integration of marker DNA into the chromosomal fragile site at 3p14: an approach to cloning fragile sites.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(15):6657-61.
1991: John Anastasi; James W Vardiman; R Rudinsky; M Patel; James B Nachman; C M Rubin; Michelle M Le Beau
Direct correlation of cytogenetic findings with cell morphology using in situ hybridization: an analysis of suspicious cells in bone marrow specimens of two patients completing therapy for acute lymphoblastic leukemia.
Blood 1991;77(11):2456-62.
1991: S Patwardhan; A Gashler; M G Siegel; L C Chang; L J Joseph; TB Shows; Michelle M Le Beau; Vikas P Sukhatme
EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors.
Oncogene 1991;6(6):917-28.
1991: Y S Li; Michelle M Le Beau; R Mick; Janet D Rowley
The proportion of abnormal karyotypes in acute leukemia samples related to method of preparation.
Cancer genetics and cytogenetics 1991;52(1):93-100.
1991: John Anastasi; M Thangavelu; James W Vardiman; A L Hooberman; M L Bian; Richard A Larson; Michelle M Le Beau
Interphase cytogenetic analysis detects minimal residual disease in a case of acute lymphoblastic leukemia and resolves the question of origin of relapse after allogeneic bone marrow transplantation.
Blood 1991;77(5):1087-91.
1991: Richard A Larson; C L Lukin; K M Daly; R Mick; Steven D Gore; Michelle M Le Beau
Circulating immune complexes correlate with remission duration in acute myeloid leukemia.
Leukemia 1991;5(2):131-7.
1991: C M Rubin; Michelle M Le Beau
Cytogenetic abnormalities in childhood acute lymphoblastic leukemia.
The American journal of pediatric hematology/oncology 1991;13(2):202-16.
1991: A N Lorenzana; C M Rubin; Michelle M Le Beau; James B Nachman; P Connolly; U Subramanian; F L Johnson; Timothy W McKeithan
Immunoglobulin gene rearrangements in acute lymphoblastic leukemia with the 9;11 translocation.
Genes, chromosomes & cancer 1991;3(1):74-7.
1991: Rafael Espinosa; R S Lemons; R K Perlman; W L Kuo; Marsha Rich Rosner; Michelle M Le Beau
Localization of the gene encoding insulin-degrading enzyme to human chromosome 10, bands q23----q25.
Cytogenetics and cell genetics 1991;57(4):184-6.
1991: M Rosenberg; Elaine Fuchs; Michelle M Le Beau; R L Eddy; TB Shows
Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12.
Cytogenetics and cell genetics 1991;57(1):33-8.
1990: C M Rubin; Richard A Larson; John Anastasi; J N Winter; M Thangavelu; James W Vardiman; Janet D Rowley; Michelle M Le Beau
t(3;21)(q26;q22): a recurring chromosomal abnormality in therapy-related myelodysplastic syndrome and acute myeloid leukemia.
Blood 1990;76(12):2594-8.
1990: D D Mikol; M J Alexakos; C A Bayley; R S Lemons; Michelle M Le Beau; Kari Stefansson
Structure and chromosomal localization of the gene for the oligodendrocyte-myelin glycoprotein.
The Journal of cell biology 1990;111(6 Pt 1):2673-9.
1990: Michael A Becker; S A Heidler; Graeme I Bell; S Seino; Michelle M Le Beau; Carol A Westbrook; W Neuman; Lawrence J Shapiro; Thuluvancheri K Mohandas; Blake J Roessler
Cloning of cDNAs for human phosphoribosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genes.
Genomics 1990;8(3):555-61.
1990: M Thangavelu; Olufunmilayo I Olopade; E Beckman; James W Vardiman; Richard A Larson; Timothy W McKeithan; Michelle M Le Beau; Janet D Rowley
Clinical, morphologic, and cytogenetic characteristics of patients with lymphoid malignancies characterized by both t(14;18)(q32;q21) and t(8;14)(q24;q32) or t(8;22)(q24;q11).
Genes, chromosomes & cancer 1990;2(2):147-58.
1990: M A Bitter; W A Franklin; Richard A Larson; Timothy W McKeithan; C M Rubin; Michelle M Le Beau; JK Stephens; James W Vardiman
Morphology in Ki-1(CD30)-positive non-Hodgkin's lymphoma is correlated with clinical features and the presence of a unique chromosomal abnormality, t(2;5)(p23;q35).
The American journal of surgical pathology 1990;14(4):305-16.
1990: Jeffrey R Gulcher; M J Alexakos; Michelle M Le Beau; R S Lemons; Kari Stefansson
Chromosomal localization of the human hexabrachion (tenascin) gene and evidence for recent reduplication within the gene.
Genomics 1990;6(4):616-22.
1990: Michelle M Le Beau
Chromosomal abnormalities in non-Hodgkin's lymphomas.
Seminars in oncology 1990;17(1):20-9.
1990: Manuel O Diaz; C M Rubin; A Harden; S Ziemin; Richard A Larson; Michelle M Le Beau; Janet D Rowley
Deletions of interferon genes in acute lymphoblastic leukemia.
The New England journal of medicine 1990;322(2):77-82.
1990: S C Chandrasekharappa; M S Rebelsky; T A Firak; Michelle M Le Beau; Carol A Westbrook
A long-range restriction map of the interleukin-4 and interleukin-5 linkage group on chromosome 5.
Genomics 1990;6(1):94-9.
1990: John Anastasi; Michelle M Le Beau; James W Vardiman; Carol A Westbrook
Detection of numerical chromosomal abnormalities in neoplastic hematopoietic cells by in situ hybridization with a chromosome-specific probe.
The American journal of pathology 1990;136(1):131-9.
1990: Michelle M Le Beau
Cytogenetic and molecular analysis of the deletions of chromosome 5 in myeloid disorders.
Progress in clinical and biological research 1990;352():277-85.
1990: Michelle M Le Beau
Chromosomal abnormalities in hematologic malignant diseases.
Progress in clinical and biological research 1990;340B():325-35.
1989: Michelle M Le Beau; M A Bitter; Richard A Larson; L A Doane; E D Ellis; W A Franklin; C M Rubin; M E Kadin; James W Vardiman
The t(2;5)(p23;q35): a recurring chromosomal abnormality in Ki-1-positive anaplastic large cell lymphoma.
Leukemia 1989;3(12):866-70.
1989: Rafael Espinosa; J E Sadler; Michelle M Le Beau
Regional localization of the human thrombomodulin gene to 20p12-cen.
Genomics 1989;5(3):649-50.
1989: J K Park; Timothy W McKeithan; Michelle M Le Beau; M A Bitter; W A Franklin; Janet D Rowley; Manuel O Diaz
An (8;14)(q24;q11) translocation involving the T-cell receptor alpha-chain gene and the MYC oncogene 3' region in a B-cell lymphoma.
Genes, chromosomes & cancer 1989;1(1):15-22.
1989: M Thangavelu; Michelle M Le Beau
Chromosomal abnormalities in Hodgkin's disease.
Hematology/oncology clinics of North America 1989;3(2):221-36.
1989: A L Hooberman; J J Carrino; D Leibowitz; Janet D Rowley; Michelle M Le Beau; Z A Arlin; Carol A Westbrook
Unexpected heterogeneity of BCR-ABL fusion mRNA detected by polymerase chain reaction in Philadelphia chromosome-positive acute lymphoblastic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):4259-63.
1989: O L Olopade; John Anastasi; M Thangavelu; Michelle M Le Beau; HM Golomb
Cytogenetic abnormalities in a secondary lymphoma complicating cardiac transplantation.
Leukemia 1989;3(4):303-4.
1989: Jeffrey L Schwartz; T Karrison; Michelle M Le Beau; Richard A Larson; D Sagher; B Strauss; Janet D Rowley; R R Weichselbaum
Chromosomal sensitivity of lymphocytes from individuals with therapy-related acute nonlymphocytic leukemia.
Mutation research 1989;216(2):119-26.
1989: Michelle M Le Beau; R S Lemons; Rafael Espinosa; Richard A Larson; N Arai; Janet D Rowley
Interleukin-4 and interleukin-5 map to human chromosome 5 in a region encoding growth factors and receptors and are deleted in myeloid leukemias with a del(5q).
Blood 1989;73(3):647-50.
1989: M Thangavelu; M A Bitter; Richard A Larson; Elizabeth M Davis; Janet D Rowley; Michelle M Le Beau
Der(5)t(5;7)(q11.2;p11.2): a new recurring abnormality in malignant myeloid disorders.
Cancer genetics and cytogenetics 1989;37(1):1-8.
1989: Janet D Rowley; Michelle M Le Beau
Cytogenetic and molecular analysis of therapy-related leukemia.
Annals of the New York Academy of Sciences 1989;567():130-40.
1988: Y S Li; John Anastasi; Richard A Larson; Michelle M Le Beau; James W Vardiman; Janet D Rowley
A recurring chromosome rearrangement, dic(16;22), in acute nonlymphocytic leukemia.
Cancer genetics and cytogenetics 1988;35(2):143-50.
1988: Richard A Larson; M Wernli; Michelle M Le Beau; K M Daly; L H Pape; Janet D Rowley; James W Vardiman
Short remission durations in therapy-related leukemia despite cytogenetic complete responses to high-dose cytarabine.
Blood 1988;72(4):1333-9.
1988: L J Joseph; Michelle M Le Beau; G A Jamieson; S Acharya; TB Shows; J D Rowley; Vikas P Sukhatme
Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(19):7164-8.
1988: J Anastasi; M J Pettenati; Michelle M Le Beau; H C Kwaan; S C Weil
Acute lymphoblastic leukemia in a patient with longstanding polycythemia vera: cytogenetic analysis reveals two distinct abnormal clones.
American journal of hematology 1988;29(1):33-7.
1988: Manuel O Diaz; S Ziemin; Michelle M Le Beau; PAULA PITHA-ROWE; Stephen Dale Smith; R R Chilcote; Janet D Rowley
Homozygous deletion of the alpha- and beta 1-interferon genes in human leukemia and derived cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(14):5259-63.
1988: K V Shepard; R Larson; Michelle M Le Beau; L Leichman; B Levin
Acute leukemia occurring after radiotherapy and chemotherapy with a nitrosourea, PCNU.
Investigational new drugs 1988;6(2):121-4.
1988: S C Weil; G L Rosner; M S Reid; Rex Chisholm; R S Lemons; M S Swanson; J J Carrino; Manuel O Diaz; Michelle M Le Beau
Translocation and rearrangement of myeloperoxidase gene in acute promyelocytic leukemia.
Science (New York, N.Y.) 1988;240(4853):790-2.
1988: Rosann A Farber; T Phalen; W L Neuman; Michelle M Le Beau; J J Wasmuth; M Dobbs
An anonymous DNA segment pTP5E (D5S70) maps to the long arm of chromosome 5 and identifies a Taq I polymorphism.
Nucleic acids research 1988;16(5):2360.
1988: Carol A Westbrook; C M Rubin; J J Carrino; Michelle M Le Beau; A Bernards; Janet D Rowley
Long-range mapping of the Philadelphia chromosome by pulsed-field gel electrophoresis.
Blood 1988;71(3):697-702.
1988: Michelle M Le Beau
Chromosomal fragile sites and cancer-specific breakpoints--a moderating viewpoint.
Cancer genetics and cytogenetics 1988;31(1):55-61.
1988: B L Samuels; Richard A Larson; Michelle M Le Beau; K M Daly; M A Bitter; James W Vardiman; C M Barker; Janet D Rowley; HM Golomb
Specific chromosomal abnormalities in acute nonlymphocytic leukemia correlate with drug susceptibility in vivo.
Leukemia 1988;2(2):79-83.
1988: M Rosenberg; A RayChaudhury; TB Shows; Michelle M Le Beau; Elaine Fuchs
A group of type I keratin genes on human chromosome 17: characterization and expression.
Molecular and cellular biology 1988;8(2):722-36.
1988: B N Harris; Elizabeth M Davis; Michelle M Le Beau; M A Bitter; L S Kaminer; E Morgan; Janet D Rowley
Variant translocations (9;11): identification of the critical genetic rearrangement.
Cancer genetics and cytogenetics 1988;30(1):171-5.
1987: Michelle M Le Beau; R S Lemons; J J Carrino; M J Pettenati; L M Souza; Manuel O Diaz; Janet D Rowley
Chromosomal localization of the human G-CSF gene to 17q11 proximal to the breakpoint of the t(15;17) in acute promyelocytic leukemia.
Leukemia 1987;1(12):795-9.
1987: C M Rubin; Richard A Larson; M A Bitter; J J Carrino; Michelle M Le Beau; Manuel O Diaz; Janet D Rowley
Association of a chromosomal 3;21 translocation with the blast phase of chronic myelogenous leukemia.
Blood 1987;70(5):1338-42.
1987: Mark J Ratain; L S Kaminer; Jacob Bitran; Richard A Larson; Michelle M Le Beau; C Skosey; S Purl; Philip C Hoffman; James L Wade Iii; James W Vardiman
Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung.
Blood 1987;70(5):1412-7.
1987: M A Bitter; James B Nachman; N Jones; W A Franklin; Michelle M Le Beau; James W Vardiman
Nonlymphoblastic T-cell lymphoma in children.
Cancer 1987;59(12):2099-103.
1987: M J Pettenati; Michelle M Le Beau; R S Lemons; E A Shima; E S Kawasaki; Richard A Larson; C J Sherr; Manuel O Diaz; Janet D Rowley
Assignment of CSF-1 to 5q33.1: evidence for clustering of genes regulating hematopoiesis and for their involvement in the deletion of the long arm of chromosome 5 in myeloid disorders.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(9):2970-4.
1987: Carol A Westbrook; C M Rubin; Michelle M Le Beau; L S Kaminer; Stephen Dale Smith; Janet D Rowley; M O Diaz
Molecular analysis of TCRB and ABL in a t(7;9)-containing cell line (SUP-T3) from a human T-cell leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(1):251-5.
1986: Michelle M Le Beau; T W McKeithan; E A Shima; R E Goldman-Leikin; S J Chan; G I Bell; Janet D Rowley; Manuel O Diaz
T-cell receptor alpha-chain gene is split in a human T-cell leukemia cell line with a t(11;14)(p15;q11).
Proceedings of the National Academy of Sciences of the United States of America 1986;83(24):9744-8.
1986: T W McKeithan; E A Shima; Michelle M Le Beau; J Minowada; Janet D Rowley; Manuel O Diaz
Molecular cloning of the breakpoint junction of a human chromosomal 8;14 translocation involving the T-cell receptor alpha-chain gene and sequences on the 3' side of MYC.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(17):6636-40.
1986: E A Shima; Michelle M Le Beau; T W McKeithan; J Minowada; L C Showe; T W Mak; M D Minden; Janet D Rowley; Manuel O Diaz
Gene encoding the alpha chain of the T-cell receptor is moved immediately downstream of c-myc in a chromosomal 8;14 translocation in a cell line from a human T-cell leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(10):3439-43.
1986: Michelle M Le Beau; M J Pettenati; R S Lemons; Manuel O Diaz; C A Westbrook; Richard A Larson; C J Sherr; Janet D Rowley
Assignment of the GM-CSF, CSF-1, and FMS genes to human chromosome 5 provides evidence for linkage of a family of genes regulating hematopoiesis and for their involvement in the deletion (5q) in myeloid disorders.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 2():899-909.