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Guy Le Breton

Research Profile

Anatomy

Physiology

Platelet Aggregation

Chemicals & Drugs

Co-author Network

Publications

TOP 3
Feng Qian; Dianqing Wu; Jia Chen; John W Christman; Jing Deng; Guy C Le Breton; Richard D Ye
Role for the guanine nucleotide exchange factor phosphatidylinositol-3,4,5-trisphosphate-dependent rac exchanger 1 in platelet secretion and aggregation.
An Xie; Jun Yan; Lan Yue; Haohua Qian; Robert F Standaert; Heba Abdel-Halim; Mary Chebib; Feng Feng; Guy C Le Breton; Fozia Mir; David R Pepperberg
2-Aminoethyl methylphosphonate, a potent and rapidly acting antagonist of GABA(A)-ρ1 receptors.
HA Gussin; Fadi T Khasawneh; Guy C Le Breton; Adnan Memic; Haohua Qian; An Xie; Feng Feng; David R Pepperberg
Subunit-specific polyclonal antibody targeting human ρ1 GABA(C) receptor.

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All Publications

2012: Feng Qian; Dianqing Wu; Jia Chen; John W Christman; Jing Deng; Guy C Le Breton; Richard D Ye
Role for the guanine nucleotide exchange factor phosphatidylinositol-3,4,5-trisphosphate-dependent rac exchanger 1 in platelet secretion and aggregation.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(3):768-77.
2011: An Xie; Jun Yan; Lan Yue; Haohua Qian; Robert F Standaert; Heba Abdel-Halim; Mary Chebib; Feng Feng; Guy C Le Breton; Fozia Mir; David R Pepperberg
2-Aminoethyl methylphosphonate, a potent and rapidly acting antagonist of GABA(A)-ρ1 receptors.
Molecular pharmacology 2011;80(6):965-78.
2011: HA Gussin; Fadi T Khasawneh; Guy C Le Breton; Adnan Memic; Haohua Qian; An Xie; Feng Feng; David R Pepperberg
Subunit-specific polyclonal antibody targeting human ρ1 GABA(C) receptor.
Experimental eye research 2011;93(1):59-64.
2009: Subhashini Srinivasan; Fozia Mir; Jin-Sheng Huang; Fadi T Khasawneh; Stephen C-T Lam; Guy C Le Breton
The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels.
The Journal of biological chemistry 2009;284(24):16108-17.
2008: Fozia Mir; Guy C Le Breton
A novel nuclear signaling pathway for thromboxane A2 receptors in oligodendrocytes: evidence for signaling compartmentalization during differentiation.
Molecular and cellular biology 2008;28(20):6329-41.
2008: Fadi T Khasawneh; Jin-Sheng Huang; Fozia Mir; Subhashini Srinivasan; Chinnaswamy Tiruppathi; Guy C Le Breton
Characterization of isoprostane signaling: evidence for a unique coordination profile of 8-iso-PGF(2alpha) with the thromboxane A(2) receptor, and activation of a separate cAMP-dependent inhibitory pathway in human platelets.
Biochemical pharmacology 2008;75(12):2301-15.
2007: Jin-Sheng Huang; Lanlan Dong; Tohru Kozasa; Guy C Le Breton
Signaling through G(alpha)13 switch region I is essential for protease-activated receptor 1-mediated human platelet shape change, aggregation, and secretion.
The Journal of biological chemistry 2007;282(14):10210-22.
2006: Santosh K Ramamurthy; Fozia Mir; Robert Gould; Guy C Le Breton
Characterization of thromboxane A2 receptor signaling in developing rat oligodendrocytes: nuclear receptor localization and stimulation of myelin basic protein expression.
Journal of neuroscience research 2006;84(7):1402-14.
2006: Fadi T Khasawneh; Jin-Sheng Huang; Joseph W Turek; Guy C Le Breton
Differential mapping of the amino acids mediating agonist and antagonist coordination with the human thromboxane A2 receptor protein.
The Journal of biological chemistry 2006;281(37):26951-65.
2006: Jin-Sheng Huang; Lanlan Dong; Guy C Le Breton
Mass-dependent signaling between G protein coupled receptors.
Cellular signalling 2006;18(4):564-76.
2005: Xin Lin; Santosh K Ramamurthy; Guy C Le Breton
Thromboxane A receptor-mediated cell proliferation, survival and gene expression in oligodendrocytes.
Journal of neurochemistry 2005;93(2):257-68.
2004: Jin-Sheng Huang; Santosh K Ramamurthy; Xin Lin; Guy C Le Breton
Cell signalling through thromboxane A2 receptors.
Cellular signalling 2004;16(5):521-33.
2003: Zhenyu Li; Guoying Zhang; Guy C Le Breton; Xiao-Pei Gao; Asrar B Malik; Xiaoping Du
Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases.
The Journal of biological chemistry 2003;278(33):30725-31.
2003: Jeanne M Manganello; Jin-Sheng Huang; Tohru Kozasa; Tatyana Voyno-Yasenetskaya; Guy C Le Breton
Protein kinase A-mediated phosphorylation of the Galpha13 switch I region alters the Galphabetagamma13-G protein-coupled receptor complex and inhibits Rho activation.
The Journal of biological chemistry 2003;278(1):124-30.
2002: Joseph W Turek; Thérêse Halmos; Nora L Sullivan; Kostas Antonakis; Guy C Le Breton
Mapping of a ligand-binding site for the human thromboxane A2 receptor protein.
The Journal of biological chemistry 2002;277(19):16791-7.
2001: Naser Muja; SC Blackman; Guy C Le Breton; George Henry De Vries
Identification and functional characterization of thromboxane A2 receptors in Schwann cells.
Journal of neurochemistry 2001;78(3):446-56.
2000: Y Djellas; Kostas Antonakis; Guy C Le Breton
Shifts in the affinity distribution of one class of seven-transmembrane receptors by activation of a separate class of seven-transmembrane receptors.
Biochemical pharmacology 2000;59(12):1521-9.
1999: Thérêse Halmos; Joseph W Turek; Guy C Le Breton; Kostas Antonakis
Synthesis and biological characterization of sqbazide, a novel biotinylated photoaffinity probe for the study of the human platelet thromboxane A2 receptor.
Bioorganic & medicinal chemistry letters 1999;9(20):2963-8.
1999: Jeanne M Manganello; Y Djellas; C Borg; Kostas Antonakis; Guy C Le Breton
Cyclic AMP-dependent phosphorylation of thromboxane A(2) receptor-associated Galpha(13).
The Journal of biological chemistry 1999;274(39):28003-10.
1999: Y Djellas; Jeanne M Manganello; Kostas Antonakis; Guy C Le Breton
Identification of Galpha13 as one of the G-proteins that couple to human platelet thromboxane A2 receptors.
The Journal of biological chemistry 1999;274(20):14325-30.
1999: SC Blackman; C Borg; David C Yeomans; Guy C Le Breton
Assessment of cellular localization of the thromboxane A2 receptor by immunocytochemistry.
Methods in molecular biology (Clifton, N.J.) 1999;120():145-71.
1998: Y Djellas; Kostas Antonakis; Guy C Le Breton
A molecular mechanism for signaling between seven-transmembrane receptors: evidence for a redistribution of G proteins.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10944-8.
1998: SC Blackman; G Dawson; Kostas Antonakis; Guy C Le Breton
The identification and characterization of oligodendrocyte thromboxane A2 receptors.
The Journal of biological chemistry 1998;273(1):475-83.
1996: D Komiotis; JD Wencel-Drake; J P Dieter; C T Lim; Guy C Le Breton
Labeling of human platelet plasma membrane thromboxane A2/prostaglandin H2 receptors using SQB, a novel biotinylated receptor probe.
Biochemical pharmacology 1996;52(5):763-70.
1996: F Nakamura; Richard D Minshall; Guy C Le Breton; Sara F Rabito
Thromboxane A2 mediates the stimulation of inositol 1,4,5-trisphosphate production and intracellular calcium mobilization by bradykinin in neonatal rat ventricular cardiomyocytes.
Hypertension 1996;28(3):444-9.
1996: Barbara A Bresnahan; Guy C Le Breton; Elias A Lianos
Localization of authentic thromboxane A2/prostaglandin H2 receptor in the rat kidney.
Kidney international 1996;49(5):1207-13.
1996: P G Swann; R A Casanova; A Desai; M M Frauenhoff; M Urbancic; U Slomczynska; A J Hopfinger; Guy C Le Breton; Duane L Venton
Nonspecific protease-catalyzed hydrolysis/synthesis of a mixture of peptides: product diversity and ligand amplification by a molecular trap.
Biopolymers 1996;40(6):617-25.
1995: C Astarie-Dequeker; M G Pernollet; Guy C Le Breton; Marie-Aude Devynck
Endothelin-3 reduces Ca(2+)-uptake and Ca2+ content of platelet internal stores.
Biochemical and biophysical research communications 1995;210(3):889-97.
1995: M G Pernollet; C Astarie-Dequeker; Guy C Le Breton; Marie-Aude Devynck
Endothelin-3 decreases Ca2+ uptake in platelet membrane vesicles.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S145-7.
1994: C Borg; C T Lim; David C Yeomans; J P Dieter; D Komiotis; E G Anderson; Guy C Le Breton
Purification of rat brain, rabbit aorta, and human platelet thromboxane A2/prostaglandin H2 receptors by immunoaffinity chromatography employing anti-peptide and anti-receptor antibodies.
The Journal of biological chemistry 1994;269(8):6109-16.
1993: I Knezevic; C Borg; Guy C Le Breton
Identification of Gq as one of the G-proteins which copurify with human platelet thromboxane A2/prostaglandin H2 receptors.
The Journal of biological chemistry 1993;268(34):26011-7.
1993: C Borg; Stephen C-T Lam; J P Dieter; C T Lim; D Komiotis; Duane L Venton; Guy C Le Breton
Anti-peptide antibodies against the human blood platelet thromboxane A2/prostaglandin H2 receptor. Production, purification and characterization.
Biochemical pharmacology 1993;45(10):2071-8.
1992: D Komiotis; C T Lim; J P Dieter; Guy C Le Breton; Duane L Venton
PgH2 analogs as potential antiplatelet derivatives.
Journal of medicinal chemistry 1992;35(16):3033-9.
1992: C A Parent; M Lagarde; Duane L Venton; Guy C Le Breton
Selective modulation of the human platelet thromboxane A2/prostaglandin H2 receptor by eicosapentaenoic and docosahexaenoic acids in intact platelets and solubilized platelet membranes.
The Journal of biological chemistry 1992;267(10):6541-7.
1992: I Knezevic; J P Dieter; Guy C Le Breton
Mechanism of inositol 1,4,5-trisphosphate-induced aggregation in saponin-permeabilized platelets.
The Journal of pharmacology and experimental therapeutics 1992;260(3):947-55.
1992: S O Kim; C T Lim; Stephen C-T Lam; S E Hall; D Komiotis; Duane L Venton; Guy C Le Breton
Purification of the human blood platelet thromboxane A2/prostaglandin H2 receptor protein.
Biochemical pharmacology 1992;43(2):313-22.
1991: Stephen C-T Lam; J P Dieter; L C Strebel; T M Taylor; G Muscolino; H Feinberg; Guy C Le Breton
Rapid dissociation of platelet-rich fibrin clots in vitro by a combination of plasminogen activators and antiplatelet agents.
The Journal of pharmacology and experimental therapeutics 1991;259(3):1371-8.
1991: Thomas H Schwarcz; D Eton; M I Ellenby; J Dieter; J Dy; M Tessalee; D Shrader; Guy C Le Breton
Prostacyclin production in the area of arterial endothelial denudation.
The Journal of surgical research 1991;50(6):638-42.
1990: P G Swann; C A Parent; M Croset; P Fonlupt; M Lagarde; Duane L Venton; Guy C Le Breton
Enrichment of platelet phospholipids with eicosapentaenoic acid and docosahexaenoic acid inhibits thromboxane A2/prostaglandin H2 receptor binding and function.
The Journal of biological chemistry 1990;265(35):21692-7.
1990: L T Jonathan; M Gbeassor; Chun-Tao Che; Harry H S Fong; Norman R Farnsworth; Guy C Le Breton; Duane L Venton
Pseudosemiglabrin, a platelet aggregation inhibitor from tephrosia semiglabra.
Journal of natural products 1990;53(6):1572-4.
1990: D Venton; Guy C Le Breton; E Hall
Preparation of prostaglandin H2: extended purification/analysis scheme.
Methods in enzymology 1990;187():245-52.
1990: Guy C Le Breton; C T Lim; C M Vaidya; Duane L Venton
Thromboxane A2/prostaglandin H2 receptor antagonists.
Methods in enzymology 1990;187():406-14.
1989: Jafar J Jafar; R Menoni; H Feinberg; Guy C Le Breton; R M Crowell
Selective platelet deposition during focal cerebral ischemia in cats.
Stroke; a journal of cerebral circulation 1989;20(5):664-7.
1989: R Cooper; J Lipowski; E Ford; N Shamsi; H Feinberg; Guy C Le Breton
Increased membrane-bound calcium in platelets of hypertensive patients.
Hypertension 1989;13(2):139-44.
1989: P G Swann; Duane L Venton; Guy C Le Breton
Eicosapentaenoic acid and docosahexaenoic acid are antagonists at the thromboxane A2/prostaglandin H2 receptor in human platelets.
FEBS letters 1989;243(2):244-6.
1987: J M Hettasch; Guy C Le Breton
Modulation of Ca2+ fluxes in isolated platelet vesicles: effects of cAMP-dependent protein kinase and protein kinase inhibitor on Ca2+ sequestration and release.
Biochimica et biophysica acta 1987;931(1):49-58.
1987: S K Arora; E J Kattelman; C T Lim; Guy C Le Breton; Duane L Venton
Preparation and biological evaluation of a potential photoaffinity label for the prostaglandin H2/thromboxane A2 receptor.
Journal of medicinal chemistry 1987;30(5):918-24.
1987: E J Kattelman; S K Arora; C T Lim; Duane L Venton; Guy C Le Breton
A photoaffinity label for the thromboxane A2/prostaglandin H2 receptor in human blood platelets.
FEBS letters 1987;213(1):179-83.
1987: R Zaragoza; Guy C Le Breton
Effect of single-dose aspirin on TXA2 and PGI2 cyclooxygenases in vivo.
Haemostasis 1987;17(1-2):40-8.
1986: E J Kattelman; Duane L Venton; Guy C Le Breton
Characterization of U46619 binding in unactivated, intact human platelets and determination of binding site affinities of four TXA2/PGH2 receptor antagonists (13-APA, BM 13.177, ONO 3708 and SQ 29,548).
Thrombosis research 1986;41(4):471-81.
1985: L D Brace; Duane L Venton; Guy C Le Breton
Thromboxane A2/prostaglandin H2 mobilizes calcium in human blood platelets.
The American journal of physiology 1985;249(1 Pt 2):H1-7.
1985: L D Brace; Duane L Venton; Guy C Le Breton
Reversal of thromboxane A2/prostaglandin H2 and ADP-induced calcium release in intact platelets.
The American journal of physiology 1985;249(1 Pt 2):H8-13.
1984: P T Horn; J D Kohli; Guy C Le Breton; D L Venton
Antagonism of prostanoid-induced vascular contraction by 13-azaprostanoic acid (13-APA).
Journal of cardiovascular pharmacology 1984;6(4):609-13.
1984: N I Ghali; E J Kattelman; S C Hung; K E Schnorf; Guy C Le Breton; Duane L Venton
Synthesis of [17,18-3H] trans-13-azaprostanoic acid. A labeled probe for the PGH2/TXA2 receptor.
Prostaglandins 1984;27(6):865-76.
1984: Guy C Le Breton; S C Hung; N I Ghali; Duane L Venton
2-(6-carboxyhexyl)cyclopentanone hexylhydrazone: a potent inhibitor of the blood platelet cyclo-oxygenase.
Prostaglandins 1984;27(4):543-51.
1984: Guy C Le Breton; J P Lipowski; H Feinberg; Duane L Venton; T Ho; K K Wu
Antagonism of thromboxane A2/prostaglandin H2 by 13-azaprostanoic acid prevents platelet deposition to the de-endothelialized rabbit aorta in vivo.
The Journal of pharmacology and experimental therapeutics 1984;229(1):80-4.
1984: Leslie V Parise; Duane L Venton; Guy C Le Breton
Arachidonic acid-induced platelet aggregation is mediated by a thromboxane A2/prostaglandin H2 receptor interaction.
The Journal of pharmacology and experimental therapeutics 1984;228(1):240-4.
1983: D Rosenbaum; S Levitsky; Norman A Silverman; J Kohler; J Lipowski; Guy C Le Breton; H Feinberg
Cardioplegia does not prevent reperfusion injury induced by intracoronary platelet deposition.
Circulation 1983;68(3 Pt 2):II102-6.
1983: N I Ghali; Duane L Venton; S C Hung; Guy C Le Breton
2-(6-carboxyhexyl)cyclopentanone hexylhydrazone. A potent and time-dependent inhibitor of platelet aggregation.
Journal of medicinal chemistry 1983;26(7):1056-60.
1983: J P Rybicki; Guy C Le Breton
Prostaglandin H2 directly lowers human platelet cAMP levels.
Thrombosis research 1983;30(5):407-14.
1983: J P Rybicki; Duane L Venton; Guy C Le Breton
The thromboxane antagonist, 13-azaprostanoic acid, inhibits arachidonic acid-induced Ca2+ release from isolated platelet membrane vesicles.
Biochimica et biophysica acta 1983;751(1):66-73.
1983: S C Hung; N I Ghali; Duane L Venton; Guy C Le Breton
Specific binding of the thromboxane A2 antagonist 13-azaprostanoic acid to human platelet membranes.
Biochimica et biophysica acta 1983;728(2):171-8.
1982: Leslie V Parise; Duane L Venton; Guy C Le Breton
Prostacyclin potentiates 13-azaprostanoic acid-induced platelet deaggregation.
Thrombosis research 1982;28(6):721-30.
1982: H Feinberg; D S Rosenbaum; S Levitsky; Norman A Silverman; J Kohler; Guy C Le Breton
Platelet deposition after surgically induced myocardial ischemia. An etiologic factor for reperfusion injury.
The Journal of thoracic and cardiovascular surgery 1982;84(6):815-22.
1982: S C Hung; N I Ghali; Duane L Venton; Guy C Le Breton
Prostaglandin F2 alpha antagonizes thromboxane A2-induced human platelet aggregation.
Prostaglandins 1982;24(2):195-206.
1982: Leslie V Parise; Duane L Venton; Guy C Le Breton
Thromboxane A2/prostaglandin H2 directly stimulates platelet shape change independent of secreted ADP.
The Journal of pharmacology and experimental therapeutics 1982;222(1):276-81.
1981: N E Owen; Guy C Le Breton
Ca2+ mobilization in blood platelets as visualized by chlortetracycline fluorescence.
The American journal of physiology 1981;241(4):H613-9.
1981: K K Wu; Guy C Le Breton; H H Tai; Y C Chen
Abnormal platelet response to thromboxane A2.
The Journal of clinical investigation 1981;67(6):1801-4.
1980: N E Owen; H Feinberg; Guy C Le Breton
Epinephrine induces Ca2+ uptake in human blood platelets.
The American journal of physiology 1980;239(4):H483-H488.
1980: W C Sandler; Guy C Le Breton; H Feinberg
Movement of sodium into human platelets.
Biochimica et biophysica acta 1980;600(2):448-55.
1980: N E Owen; Guy C Le Breton
The involvement of calcium in epinephrine or ADP potentiation of human platelet aggregation.
Thrombosis research 1980;17(6):855-63.
1980: Guy C Le Breton; Duane L Venton
Thromboxane A2 receptor antagonism selectively reverses platelet aggregation.
Advances in prostaglandin and thromboxane research 1980;6():497-503.
1979: Guy C Le Breton; D L Venton; S E Enke; Perry V Halushka
13-Azaprostanoic acid: a specific antagonist of the human blood platelet thromboxane/endoperoxide receptor.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(8):4097-101.
1979: D L Venton; S E Enke; Guy C Le Breton
Azaprostanoic acid derivatives. Inhibitors of arachidonic acid induced platelet aggregation.
Journal of medicinal chemistry 1979;22(7):824-30.
1977: Guy C Le Breton; P C Hoffmann
Ubiquinone and cytochrome b in isolated rat heart.
Journal of molecular and cellular cardiology 1977;9(12):967-87.
1977: H Feinberg; W C Sandler; M Scorer; Guy C Le Breton; B Grossman; G V Born
Movement of sodium into human platelets induced by ADP.
Biochimica et biophysica acta 1977;470(2):317-24.
1977: Guy C Le Breton; R J Dinerstein
Effect of the calcium antagonist TMB-6 on intracellular calcium redistribution associated with platelet shape change.
Thrombosis research 1977;10(3):521-3.
1976: Guy C Le Breton; R J Dinerstein; L J Roth; H Feinberg
Direct evidence for intracellular divalent cation redistribution associated with platelet shape change.
Biochemical and biophysical research communications 1976;71(1):362-70.
1976: Guy C Le Breton; W C Sandler; H Feinberg
The effect of D2O and chlortetracycline on ADP-induced platelet shape change and aggregation.
Thrombosis research 1976;8(4):477-85.