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Laurent Le Cam

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Publications

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Matthieu Lacroix; Laëtitia K Linares; Laurent Le Cam
[The Yin and the Yang of senescence: is it possible to age without developing cancer?].
Elodie Hatchi; Geneviève Rodier; Claude Sardet; Laurent Le Cam
E4F1 dysfunction results in autophagic cell death in myeloid leukemic cells.
Elodie Hatchi; Chantal Jacquet; Olivier Kirsh; Matthieu Lacroix; Sylviane Lagarrigue; Laëtitia K Linares; Gwendaline Lledo; Genevieve Rodier; Claude Sardet; Emilie Schrepfer; Sylvie Tondeur; Julie Caramel; Pierre Dubus; Laurent Le Cam
E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells.

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All Publications

2012: Matthieu Lacroix; Laëtitia K Linares; Laurent Le Cam
[The Yin and the Yang of senescence: is it possible to age without developing cancer?].
Médecine sciences : M/S 2012;28(3):245-7.
2011: Elodie Hatchi; Geneviève Rodier; Claude Sardet; Laurent Le Cam
E4F1 dysfunction results in autophagic cell death in myeloid leukemic cells.
Autophagy 2011;7(12):1566-7.
2011: Elodie Hatchi; Chantal Jacquet; Olivier Kirsh; Matthieu Lacroix; Sylviane Lagarrigue; Laëtitia K Linares; Gwendaline Lledo; Genevieve Rodier; Claude Sardet; Emilie Schrepfer; Sylvie Tondeur; Julie Caramel; Pierre Dubus; Laurent Le Cam
E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells.
The Journal of experimental medicine 2011;208(7):1403-17.
2007: Laëtitia K Linares; Rosemary Kiernan; Robinson Triboulet; Christine Chable-Bessia; Daniel Latreille; olivier cuvier; Matthieu Lacroix; Laurent Le Cam; Olivier Coux; Monsef Benkirane
Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2.
Nature cell biology 2007;9(3):331-8.
2006: Laurent Le Cam; Laëtitia K Linares; Conception Paul; Eric Julien; Matthieu Lacroix; Elodie Hatchi; Robinson Triboulet; Guillaume Bossis; Ayelet Shmueli; Manuel S Rodriguez; Olivier Coux; Claude Sardet
E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.
Cell 2006;127(4):775-88.
2006: Conception Paul; Matthieu Lacroix; I Iankova; Eric Julien; B W Schäfer; C Labalette; Y Wei; A Le Cam; Laurent Le Cam; Claude Sardet
The LIM-only protein FHL2 is a negative regulator of E4F1.
Oncogene 2006;25(40):5475-84.
2004: Laurent Le Cam; Matthieu Lacroix; Maria A Ciemerych; Claude Sardet; Piotr Sicinski
The E4F protein is required for mitotic progression during embryonic cell cycles.
Molecular and cellular biology 2004;24(14):6467-75.
2003: Ewa Sicinska; Ioannis Aifantis; Laurent Le Cam; Wojciech Swat; Christine Borowski; Qunyan Yu; Adolfo Ferrando; Steven D Levin; Yan Geng; Harald von Boehmer; Piotr Sicinski
Requirement for cyclin D3 in lymphocyte development and T cell leukemias.
Cancer cell 2003;4(6):451-61.
2002: Steven Catchpole; Fiona J Tavner; Laurent Le Cam; Claude Sardet; Roger J Watson
A B-myb promoter corepressor site facilitates in vivo occupation of the adjacent E2F site by p107 x E2F and p130 x E2F complexes.
The Journal of biological chemistry 2002;277(41):39015-24.
2001: Jolanta Polanowska; Eric Fabbrizio; Laurent Le Cam; D Trouche; Stéphane Emiliani; Rafael E Herrera; Claude Sardet
The periodic down regulation of Cyclin E gene expression from exit of mitosis to end of G(1) is controlled by a deacetylase- and E2F-associated bipartite repressor element.
Oncogene 2001;20(31):4115-27.
2000: Lluis Fajas; Conception Paul; O Zugasti; Laurent Le Cam; Jolanta Polanowska; Eric Fabbrizio; R Medema; Marie-Luce Vignais; Claude Sardet
pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7738-43.
2000: Jolanta Polanowska; Laurent Le Cam; Béatrice Orsetti; H Vallés; Eric Fabbrizio; Lluis Fajas; S Taviaux; Charles Theillet; Claude Sardet
Human E2F5 gene is oncogenic in primary rodent cells and is amplified in human breast tumors.
Genes, chromosomes & cancer 2000;28(1):126-30.
2000: Lluis Fajas; Laurent Le Cam; Jolanta Polanowska; Eric Fabbrizio; Nadège Servant; Alexandre Philips; Gilles Carnac; Claude Sardet
A CDE/CHR-like element mediates repression of transcription of the mouse RB2 (p130) gene.
FEBS letters 2000;471(1):29-33.
2000: Christine Courtes; N Lecointe; Laurent Le Cam; F Baudoin; Claude Sardet; D Mathieu-Mahul
Erythroid-specific inhibition of the tal-1 intragenic promoter is due to binding of a repressor to a novel silencer.
The Journal of biological chemistry 2000;275(2):949-58.
1999: Eric Fabbrizio; Laurent Le Cam; Jolanta Polanowska; M Kaczorek; Ned J C Lamb; R Brent; Claude Sardet
Inhibition of mammalian cell proliferation by genetically selected peptide aptamers that functionally antagonize E2F activity.
Oncogene 1999;18(30):4357-63.
1999: Laurent Le Cam; Jolanta Polanowska; Lluis Fajas; Eric Fabbrizio; Claude Sardet
Improved LM-PCR procedure for in vivo footprinting analysis of GC-rich promoters.
BioTechniques 1999;26(5):840-3.
1999: Laurent Le Cam; Jolanta Polanowska; Eric Fabbrizio; Magali Olivier; Alexandre Philips; E Ng Eaton; M Classon; Yan Geng; Claude Sardet
Timing of cyclin E gene expression depends on the regulated association of a bipartite repressor element with a novel E2F complex.
The EMBO journal 1999;18(7):1878-90.
1998: G Hateboer; A Wobst; BO Petersen; Laurent Le Cam; E Vigo; Claude Sardet; Kristian Helin
Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F.
Molecular and cellular biology 1998;18(11):6679-97.
1998: X Espanel; Laurent Le Cam; S North; Claude Sardet; Gilbert Brun; G Gillet
Regulation of E2F-1 gene expression in avian cells.
Oncogene 1998;17(5):585-94.
1998: Alexandre Philips; X Huet; A Plet; Laurent Le Cam; Annick Vié; Jean-Marie Blanchard
The retinoblastoma protein is essential for cyclin A repression in quiescent cells.
Oncogene 1998;16(11):1373-81.