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Timothy Le Cras

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Gerald B Lee; Chang Xiao; Timothy D Le Cras; Eric B Brandt; Lou Ann S Brown; Anne M Fitzpatrick; Aaron M Gibson; Gurjit K Khurana Hershey
Diesel exhaust particles induce cysteine oxidation and s-glutathionylation in house dust mite induced murine asthma.
Elizabeth M Mushaben; Eric B Brandt; Gurjit K Khurana Hershey; Timothy D Le Cras
Differential effects of rapamycin and dexamethasone in mouse models of established allergic asthma.
Elizabeth M Mushaben; William C Nichols; Michael W Pauciulo; Gurjit Khurana Hershey; Timothy D Le Cras
Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph and wild-type mice.

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2013: Gerald B Lee; Chang Xiao; Timothy D Le Cras; Eric B Brandt; Lou Ann S Brown; Anne M Fitzpatrick; Aaron M Gibson; Gurjit K Khurana Hershey
Diesel exhaust particles induce cysteine oxidation and s-glutathionylation in house dust mite induced murine asthma.
PloS one 2013;8(3):e60632.
2013: Elizabeth M Mushaben; Eric B Brandt; Gurjit K Khurana Hershey; Timothy D Le Cras
Differential effects of rapamycin and dexamethasone in mouse models of established allergic asthma.
PloS one 2013;8(1):e54426.
2012: Elizabeth M Mushaben; William C Nichols; Michael W Pauciulo; Gurjit Khurana Hershey; Timothy D Le Cras
Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph and wild-type mice.
PloS one 2012;7(3):e32468.
2011: Elizabeth M Mushaben; Eric B Brandt; Gurjit K Khurana Hershey; Elizabeth L Kramer; Timothy D Le Cras
Rapamycin attenuates airway hyperreactivity, goblet cells, and IgE in experimental allergic asthma.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(11):5756-63.
2011: Timothy D Le Cras; Thomas H Acciani; Elizabeth M Mushaben; Elizabeth L Kramer; Patricia A Pastura; William D Hardie; Thomas R Korfhagen; Umasundari Sivaprasad; Mark Ericksen; Aaron M Gibson; Michael J Holtzman; Jeffrey A Whitsett; Gurjit K Khurana Hershey
Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma.
American journal of physiology. Lung cellular and molecular physiology 2011;300(3):L414-21.
2011: Umasundari Sivaprasad; David J Askew; Mark B Ericksen; Aaron M Gibson; Matthew T Stier; Eric B Brandt; Stacey A Bass; Michael O Daines; Jamila Chakir; Keith F Stringer; Susan E Wert; Jeffrey A Whitsett; Timothy D Le Cras; MARSHA WILLS-KARP; Gary A Silverman; Gurjit K Khurana Hershey
A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma.
The Journal of allergy and clinical immunology 2011;127(1):254-61, 261.e1-6.
2010: MA Ryan; Kalpana J Nattamai; Ellen Xing; David Schleimer; Deidre Daria; Amitava Sengupta; Anja Köhler; Wei Liu; Matthias Gunzer; Michael Jansen; Nancy Ratner; Timothy D Le Cras; Amanda Waterstrat; Gary Van Zant; Jose A Cancelas; Yi Zheng; Hartmut Geiger
Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.
Nature medicine 2010;16(10):1141-6.
2010: Timothy D Le Cras; Thomas R Korfhagen; Cynthia Davidson; Stephanie Schmidt; Matthew Fenchel; Machiko Ikegami; Jeffrey A Whitsett; William D Hardie
Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis.
The American journal of pathology 2010;176(2):679-86.
2009: Thomas R Korfhagen; Timothy D Le Cras; Cynthia R Davidson; Stephanie M Schmidt; Machiko Ikegami; Jeffrey A Whitsett; William D Hardie
Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis.
American journal of respiratory cell and molecular biology 2009;41(5):562-72.
2009: Elizabeth L Kramer; Elizabeth M Mushaben; Patricia A Pastura; Thomas H Acciani; Gail H Deutsch; Gurjit K Khurana Hershey; Thomas R Korfhagen; William D Hardie; Jeffrey A Whitsett; Timothy D Le Cras
Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice.
American journal of respiratory cell and molecular biology 2009;41(4):415-25.
2008: Hiroshi Kida; Michael L Mucenski; Angela R Thitoff; Timothy D Le Cras; Kwon-Sik Park; Machiko Ikegami; Werner Muller; Jeffrey A Whitsett
GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium.
The American journal of pathology 2008;172(6):1542-54.
2008: William D Hardie; Cynthia Davidson; Machiko Ikegami; George Leikauf; Timothy D Le Cras; Adrienne Prestridge; Jeffrey A Whitsett; Thomas R Korfhagen
EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology 2008;294(6):L1217-25.
2007: William D Hardie; Thomas R Korfhagen; Maureen Sartor; Adrienne Prestridge; Mario Medvedovic; Timothy D Le Cras; Machiko Ikegami; Scott C Wesselkamper; Cynthia Davidson; Maggie Dietsch; William Nichols; Jeffrey A Whitsett; George Leikauf
Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.
American journal of respiratory cell and molecular biology 2007;37(3):309-21.
2007: Elizabeth L Kramer; Gail H Deutsch; Maureen Sartor; William D Hardie; Machiko Ikegami; Thomas R Korfhagen; Timothy D Le Cras
Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis.
American journal of physiology. Lung cellular and molecular physiology 2007;293(2):L314-27.
2007: Lucas Guillermo Fernandez; Timothy D Le Cras; Mirta Ruiz; David K Glover; Irving L Kron; Victor E Laubach
Differential vascular growth in postpneumonectomy compensatory lung growth.
The Journal of thoracic and cardiovascular surgery 2007;133(2):309-16.
2005: Machiko Ikegami; Timothy D Le Cras; William D Hardie; Mildred T Stahlman; Jeffrey A Whitsett; Thomas R Korfhagen
TGF-alpha perturbs surfactant homeostasis in vivo.
American journal of physiology. Lung cellular and molecular physiology 2005;289(1):L34-43.
2005: Timothy D Le Cras; Lucas Guillermo Fernandez; Patricia A Pastura; Victor E Laubach
Vascular growth and remodeling in compensatory lung growth following right lobectomy.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(3):1140-8.
2005: Ann L Akeson; James E Cameron; Timothy D Le Cras; Jeffrey A Whitsett; James M Greenberg
Vascular endothelial growth factor-A induces prenatal neovascularization and alters bronchial development in mice.
Pediatric research 2005;57(1):82-8.
2004: Suhas Kallapur; Cindy J Bachurski; Timothy D Le Cras; Shubhada N Joshi; Machiko Ikegami; Alan H Jobe
Vascular changes after intra-amniotic endotoxin in preterm lamb lungs.
American journal of physiology. Lung cellular and molecular physiology 2004;287(6):L1178-85.
2004: Timothy D Le Cras; William D Hardie; Gail H Deutsch; K H Albertine; Machiko Ikegami; Jeffrey A Whitsett; Thomas R Korfhagen
Transient induction of TGF-alpha disrupts lung morphogenesis, causing pulmonary disease in adulthood.
American journal of physiology. Lung cellular and molecular physiology 2004;287(4):L718-29.
2004: Paul R Reynolds; Michael L Mucenski; Timothy D Le Cras; William C Nichols; Jeffrey A Whitsett
Midkine is regulated by hypoxia and causes pulmonary vascular remodeling.
The Journal of biological chemistry 2004;279(35):37124-32.
2004: Timothy D Le Cras; R E Spitzmiller; K H Albertine; James M Greenberg; Jeffrey A Whitsett; Ann L Akeson
VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice.
American journal of physiology. Lung cellular and molecular physiology 2004;287(1):L134-42.
2004: William D Hardie; Timothy D Le Cras; Kenny Jiang; Jay Tichelaar; Mohamad Azhar; Thomas R Korfhagen
Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology 2004;286(4):L741-9.
2003: Timothy D Le Cras; William D Hardie; Karen A Fagan; Jeffrey A Whitsett; Thomas R Korfhagen
Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing transforming growth factor-alpha.
American journal of physiology. Lung cellular and molecular physiology 2003;285(5):L1046-54.
2003: Vivek Balasubramaniam; Timothy D Le Cras; D Dunbar Ivy; Theresa R Grover; John P Kinsella; Steven H Abman
Role of platelet-derived growth factor in vascular remodeling during pulmonary hypertension in the ovine fetus.
American journal of physiology. Lung cellular and molecular physiology 2003;284(5):L826-33.
2002: Timothy D Le Cras; Neil E Markham; Rubin M Tuder; Norbert F Voelkel; Steven H Abman
Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure.
American journal of physiology. Lung cellular and molecular physiology 2002;283(3):L555-62.
2001: Brian W Fouty; Bryn Grimison; Karen A Fagan; Timothy D Le Cras; Julie Harral; Marloes Hoedt-Miller; Robert A Sclafani; David M Rodman
p27(Kip1) is important in modulating pulmonary artery smooth muscle cell proliferation.
American journal of respiratory cell and molecular biology 2001;25(5):652-8.
2001: Henry L Galan; Timothy Regnault; Timothy D Le Cras; R Weslie Tyson; Russell V Anthony; Randall B Wilkening; Steven H Abman
Cotyledon and binucleate cell nitric oxide synthase expression in an ovine model of fetal growth restriction.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;90(6):2420-6.
2001: D Dunbar Ivy; Ivan F McMurtry; Masashi Yanagisawa; Cheryl Gariepy; Timothy D Le Cras; Sarah A Gebb; Kenneth G Morris; R C Wiseman; Steven H Abman
Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction.
American journal of physiology. Lung cellular and molecular physiology 2001;280(5):L1040-8.
2001: Timothy D Le Cras; Ivan F McMurtry
Nitric oxide production in the hypoxic lung.
American journal of physiology. Lung cellular and molecular physiology 2001;280(4):L575-82.
2000: Yasunori Kasahara; Rubin M Tuder; Laimute Taraseviciene-Stewart; Timothy D Le Cras; Steven H Abman; Peter Hirth; J Waltenberger; Norbert F Voelkel
Inhibition of VEGF receptors causes lung cell apoptosis and emphysema.
The Journal of clinical investigation 2000;106(11):1311-9.
2000: M Jakkula; Timothy D Le Cras; Sarah A Gebb; K P Hirth; Rubin M Tuder; Norbert F Voelkel; Steven H Abman
Inhibition of angiogenesis decreases alveolarization in the developing rat lung.
American journal of physiology. Lung cellular and molecular physiology 2000;279(3):L600-7.
2000: Timothy D Le Cras; D H Kim; Neil E Markham; A S Abman
Early abnormalities of pulmonary vascular development in the Fawn-Hooded rat raised at Denver's altitude.
American journal of physiology. Lung cellular and molecular physiology 2000;279(2):L283-91.
2000: Theresa R Grover; K G Ackerman; Timothy D Le Cras; A H Jobe; Steven H Abman
Repetitive prenatal glucocorticoids increase lung endothelial nitric oxide synthase expression in ovine fetuses delivered at term.
Pediatric research 2000;48(1):75-83.
2000: Timothy D Le Cras; Neil E Markham; Kenneth G Morris; C R Ahrens; Ivan F McMurtry; Steven H Abman
Neonatal dexamethasone treatment increases the risk for pulmonary hypertension in adult rats.
American journal of physiology. Lung cellular and molecular physiology 2000;278(4):L822-9.
2000: D Dunbar Ivy; Timothy D Le Cras; Thomas A Parker; Jeanne P Zenge; M Jakkula; Neil E Markham; John P Kinsella; Steven H Abman
Developmental changes in endothelin expression and activity in the ovine fetal lung.
American journal of physiology. Lung cellular and molecular physiology 2000;278(4):L785-93.
2000: Jen-Ruey Tang; Timothy D Le Cras; Kenneth G Morris; Steven H Abman
Brief perinatal hypoxia increases severity of pulmonary hypertension after reexposure to hypoxia in infant rats.
American journal of physiology. Lung cellular and molecular physiology 2000;278(2):L356-64.
2000: Thomas A Parker; Timothy D Le Cras; John P Kinsella; Steven H Abman
Developmental changes in endothelial nitric oxide synthase expression and activity in ovine fetal lung.
American journal of physiology. Lung cellular and molecular physiology 2000;278(1):L202-8.
2000: Robyn L Rairigh; Laurent Storme; Thomas A Parker; Timothy D Le Cras; Neil E Markham; M Jakkula; Steven H Abman
Role of neuronal nitric oxide synthase in regulation of vascular and ductus arteriosus tone in the ovine fetus.
American journal of physiology. Lung cellular and molecular physiology 2000;278(1):L105-10.
2000: Thomas A Parker; John P Kinsella; Henry L Galan; Timothy D Le Cras; G T Richter; Neil E Markham; Steven H Abman
Prolonged infusions of estradiol dilate the ovine fetal pulmonary circulation.
Pediatric research 2000;47(1):89-96.
1999: Timothy D Le Cras; D H Kim; Sarah A Gebb; Neil E Markham; J M Shannon; Rubin M Tuder; Steven H Abman
Abnormal lung growth and the development of pulmonary hypertension in the Fawn-Hooded rat.
The American journal of physiology 1999;277(4 Pt 1):L709-18.
1999: Robyn L Rairigh; Laurent Storme; Thomas A Parker; Timothy D Le Cras; John P Kinsella; M Jakkula; Steven H Abman
Inducible NO synthase inhibition attenuates shear stress-induced pulmonary vasodilation in the ovine fetus.
The American journal of physiology 1999;276(3 Pt 1):L513-21.
1998: D Dunbar Ivy; Timothy D Le Cras; MP Horan; Steven H Abman
Chronic intrauterine pulmonary hypertension increases preproendothelin-1 and decreases endothelin B receptor mRNA expression in the ovine fetal lung.
Chest 1998;114(1 Suppl):65S.
1998: Timothy D Le Cras; RC Tyler; MP Horan; Kenneth G Morris; I F McMurty; Roger Johns; Steven H Abman
Effects of chronic hypoxia and altered hemodynamics on endothelial nitric oxide synthase and preproendothelin-1 expression in the adult rat lung.
Chest 1998;114(1 Suppl):35S-36S.
1998: Allen Everett; Timothy D Le Cras; C Xue; Roger Johns
eNOS expression is not altered in pulmonary vascular remodeling due to increased pulmonary blood flow.
The American journal of physiology 1998;274(6 Pt 1):L1058-65.
1998: D Dunbar Ivy; Timothy D Le Cras; MP Horan; Steven H Abman
Increased lung preproET-1 and decreased ETB-receptor gene expression in fetal pulmonary hypertension.
The American journal of physiology 1998;274(4 Pt 1):L535-41.
1998: Timothy D Le Cras; RC Tyler; MP Horan; Kenneth G Morris; Rubin M Tuder; Ivan F McMurtry; Roger Johns; Steven H Abman
Effects of chronic hypoxia and altered hemodynamics on endothelial nitric oxide synthase expression in the adult rat lung.
The Journal of clinical investigation 1998;101(4):795-801.
1998: Robyn L Rairigh; Timothy D Le Cras; D Dunbar Ivy; John P Kinsella; G Richter; MP Horan; I D Fan; Steven H Abman
Role of inducible nitric oxide synthase in regulation of pulmonary vascular tone in the late gestation ovine fetus.
The Journal of clinical investigation 1998;101(1):15-21.
1997: E Villamor; Timothy D Le Cras; MP Horan; Ann C Halbower; Rubin M Tuder; Steven H Abman
Chronic intrauterine pulmonary hypertension impairs endothelial nitric oxide synthase in the ovine fetus.
The American journal of physiology 1997;272(5 Pt 1):L1013-20.
1996: Timothy D Le Cras; C Xue; A Rengasamy; Roger Johns
Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung.
The American journal of physiology 1996;270(1 Pt 1):L164-70.
1995: Roger Johns; A Tichotsky; M Muro; J P Spaeth; Timothy D Le Cras; A Rengasamy
Halothane and isoflurane inhibit endothelium-derived relaxing factor-dependent cyclic guanosine monophosphate accumulation in endothelial cell-vascular smooth muscle co-cultures independent of an effect on guanylyl cyclase activation.
Anesthesiology 1995;83(4):823-34.
1994: C Xue; A Rengasamy; Timothy D Le Cras; P A Koberna; G C Dailey; Roger Johns
Distribution of NOS in normoxic vs. hypoxic rat lung: upregulation of NOS by chronic hypoxia.
The American journal of physiology 1994;267(6 Pt 1):L667-78.