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Stuart Le Grice

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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HIV-1

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Co-Publications
Name
18
Rausch, Jason
11
Marquet, Roland
11
Ehresmann, Bernard
11
Ehresmann, Chantal
10
Miller, Jennifer
8
Wöhrl, Birgitta
8
Yi-Brunozzi, Hye Young
8
Darlix, Jean-Luc
7
Dash, Chandravanu
7
Budihas, Scott
7
Beutler, John
7
Lener, Daniela
6
Kvaratskhelia, Mamuka
6
Marino, John
6
Wamiru, Antony

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Publications

TOP 3
Turner Kevin B; Yi-Brunozzi Hye Young; Brinson Robert G; Marino John P; Fabris Daniele; Le Grice Stuart F J
SHAMS: combining chemical modification of RNA with mass spectrometry to examine polypurine tract-containing RNA/DNA hybrids.
Brinson Robert G; Turner Kevin B; Yi-Brunozzi Hye Young; Le Grice Stuart F J; Fabris Daniele; Marino John P
Probing anomalous structural features in polypurine tract-containing RNA-DNA hybrids with neomycin B.
Beilhartz Greg L; Wendeler Michaela; Baichoo Noel; Rausch Jason; Le Grice Stuart; Götte Matthias
HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.

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All Publications

2009: Turner Kevin B; Yi-Brunozzi Hye Young; Brinson Robert G; Marino John P; Fabris Daniele; Le Grice Stuart F J
SHAMS: combining chemical modification of RNA with mass spectrometry to examine polypurine tract-containing RNA/DNA hybrids.
RNA (New York, N.Y.) 2009;15(8):1605-13.
2009: Brinson Robert G; Turner Kevin B; Yi-Brunozzi Hye Young; Le Grice Stuart F J; Fabris Daniele; Marino John P
Probing anomalous structural features in polypurine tract-containing RNA-DNA hybrids with neomycin B.
Biochemistry 2009;48(29):6988-97.
2009: Beilhartz Greg L; Wendeler Michaela; Baichoo Noel; Rausch Jason; Le Grice Stuart; Götte Matthias
HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.
Journal of molecular biology 2009;388(3):462-74.
2009: Wilkinson Thomas A; Januszyk Kurt; Phillips Martin L; Tekeste Shewit S; Zhang Min; Miller Jennifer T; Le Grice Stuart F J; Clubb Robert T; Chow Samson A
Identifying and characterizing a functional HIV-1 reverse transcriptase-binding site on integrase.
The Journal of biological chemistry 2009;284(12):7931-9.
2009: Rausch Jason W; Chelico Linda; Goodman Myron F; Le Grice Stuart F J
Dissecting APOBEC3G substrate specificity by nucleoside analog interference.
The Journal of biological chemistry 2009;284(11):7047-58.
2008: Liu Shixin; Abbondanzieri Elio A; Rausch Jason W; Le Grice Stuart F J; Zhuang Xiaowei
Slide into action: dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates.
Science (New York, N.Y.) 2008;322(5904):1092-7.
2008: Dash Chandravanu; Scarth Brian J; Badorrek Christopher; Götte Matthias; Le Grice Stuart F J
Examining the ribonuclease H primer grip of HIV-1 reverse transcriptase by charge neutralization of RNA/DNA hybrids.
Nucleic acids research 2008;36(20):6363-71.
2008: Wendeler Michaela; Lee Hsiu-Fang; Bermingham Alun; Miller Jennifer T; Chertov Oleg; Bona Marion K; Baichoo Noel S; Ehteshami Maryam; Beutler John; O'Keefe Barry R; Götte Matthias; Kvaratskhelia Mamuka; Le Grice Stuart
Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity.
ACS chemical biology 2008;3(10):635-44.
2008: Ehteshami Maryam; Scarth Brian J; Tchesnokov Egor P; Dash Chandravanu; Le Grice Stuart F J; Hallenberger Sabine; Jochmans Dirk; Götte Matthias
Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors".
The Journal of biological chemistry 2008;283(44):29904-11.
2008: Legiewicz Michal; Badorrek Christopher S; Turner Kevin B; Fabris Daniele; Hamm Tiffany E; Rekosh David; Hammarskjöld Marie-Louise; Le Grice Stuart F J
Resistance to RevM10 inhibition reflects a conformational switch in the HIV-1 Rev response element.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14365-70.
2008: Bokesch Heidi R; Wamiru Antony; Le Grice Stuart F J; Beutler John A; McKee Tawnya C; McMahon James B
HIV-1 ribonuclease H inhibitory phenolic glycosides from Eugenia hyemalis.
Journal of natural products 2008;71(9):1634-6.
2008: Abbondanzieri Elio A; Bokinsky Gregory; Rausch Jason W; Zhang Jennifer X; Le Grice Stuart F J; Zhuang Xiaowei
Dynamic binding orientations direct activity of HIV reverse transcriptase.
Nature 2008;453(7192):184-9.
2008: Turner Kevin B; Brinson Robert G; Yi-Brunozzi Hye Young; Rausch Jason W; Miller Jennifer T; Le Grice Stuart F J; Marino John P; Fabris Daniele
Structural probing of the HIV-1 polypurine tract RNA:DNA hybrid using classic nucleic acid ligands.
Nucleic acids research 2008;36(8):2799-810.
2008: Yi-Brunozzi Hye Young; Brinson Robert G; Brabazon Danielle M; Lener Daniela; Le Grice Stuart F J; Marino John P
High-resolution NMR analysis of the conformations of native and base analog substituted retroviral and LTR-retrotransposon PPT primers.
Chemistry & biology 2008;15(3):254-62.
2008: Marchand Christophe; Beutler John A; Wamiru Antony; Budihas Scott; Möllmann Ute; Heinisch Lothar; Mellors John W; Le Grice Stuart F; Pommier Yves
Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H.
Antimicrobial agents and chemotherapy 2008;52(1):361-4.
2007: Takada Kentaro; Bermingham Alun; O'Keefe Barry R; Wamiru Antony; Beutler John A; Le Grice Stuart F J; Lloyd John; Gustafson Kirk R; McMahon James B
An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis.
Journal of natural products 2007;70(10):1647-9.
2007: Dat Nguyen Tien; Bae KiHwan; Wamiru Antony; McMahon James B; Le Grice Stuart F J; Bona Marion; Beutler John A; Kim Young Ho
A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H.
Journal of natural products 2007;70(5):839-41.
2007: Klarmann George J; Eisenhauer Brian M; Zhang Yi; Gotte Matthias; Pata Janice D; Chatterjee Deb K; Hecht Sidney M; Le Grice Stuart F J
Investigating the "steric gate" of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by targeted insertion of unnatural amino acids.
Biochemistry 2007;46(8):2118-26.
2007: Rausch Jason W; Le Grice Stuart F J
Exploiting structurally diverse nucleoside analogs as probes of reverse transcription complexes.
Current HIV research 2007;5(1):11-22.
2007: Rausch Jason W; Le Grice Stuart F J
Purine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis.
Nucleic acids research 2007;35(1):256-68.
2006: Dash Chandravanu; Fisher Timothy S; Prasad Vinayaka R; Le Grice Stuart F J
Examining interactions of HIV-1 reverse transcriptase with single-stranded template nucleotides by nucleoside analog interference.
The Journal of biological chemistry 2006;281(38):27873-81.
2006: Bampi Carole; Bibillo Arkadiusz; Wendeler Michaela; Divita Gilles; Gorelick Robert J; Le Grice Stuart F J; Darlix Jean-Luc
Nucleotide excision repair and template-independent addition by HIV-1 reverse transcriptase in the presence of nucleocapsid protein.
The Journal of biological chemistry 2006;281(17):11736-43.
2006: Dash Chandravanu; Marino John P; Le Grice Stuart F J
Examining Ty3 polypurine tract structure and function by nucleoside analog interference.
The Journal of biological chemistry 2006;281(5):2773-83.
2006: Mandal Dibyakanti; Dash Chandravanu; Le Grice Stuart F J; Prasad Vinayaka R
Analysis of HIV-1 replication block due to substitutions at F61 residue of reverse transcriptase reveals additional defects involving the RNase H function.
Nucleic acids research 2006;34(10):2853-63.
2005: Yi-Brunozzi Hye Young; Brabazon Danielle M; Lener Daniela; Le Grice Stuart F J; Marino John P
A ribose sugar conformational switch in the LTR-retrotransposon Ty3 polypurine tract-containing RNA/DNA hybrid.
Journal of the American Chemical Society 2005;127(47):16344-5.
2005: Bibillo Arkadiusz; Lener Daniela; Tewari Alok; Le Grice Stuart F J
Interaction of the Ty3 reverse transcriptase thumb subdomain with template-primer.
The Journal of biological chemistry 2005;280(34):30282-90.
2005: Yi-Brunozzi Hye Young; Le Grice Stuart F J
Investigating HIV-1 polypurine tract geometry via targeted insertion of abasic lesions in the (-)-DNA template and (+)-RNA primer.
The Journal of biological chemistry 2005;280(20):20154-62.
2005: Ignatov Michael E; Berdis Anthony J; Le Grice Stuart F J; Barkley Mary D
Attenuation of DNA replication by HIV-1 reverse transcriptase near the central termination sequence.
Biochemistry 2005;44(14):5346-56.
2005: Williams Kerry L; Zhang Yijun; Shkriabai Nick; Karki Rajeshri G; Nicklaus Marc C; Kotrikadze Nana; Hess Sonja; Le Grice Stuart F J; Craigie Robert; Pathak Vinay K; Kvaratskhelia Mamuka
Mass spectrometric analysis of the HIV-1 integrase-pyridoxal 5'-phosphate complex reveals a new binding site for a nucleotide inhibitor.
The Journal of biological chemistry 2005;280(9):7949-55.
2005: Budihas Scott R; Gorshkova Inna; Gaidamakov Sergei; Wamiru Antony; Bona Marion K; Parniak Michael A; Crouch Robert J; McMahon James B; Beutler John A; Le Grice Stuart F J
Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones.
Nucleic acids research 2005;33(4):1249-56.
2005: Bibillo Arkadiusz; Lener Daniela; Klarmann George J; Le Grice Stuart F J
Functional roles of carboxylate residues comprising the DNA polymerase active site triad of Ty3 reverse transcriptase.
Nucleic acids research 2005;33(1):171-81.
2004: Klarmann George J; Eisenhauer Brian M; Zhang Yi; Sitaraman Kalavathy; Chatterjee Deb K; Hecht Sidney M; Le Grice Stuart F J
Site- and subunit-specific incorporation of unnatural amino acids into HIV-1 reverse transcriptase.
Protein expression and purification 2004;38(1):37-44.
2004: Rausch Jason W; Le Grice Stuart F J
'Binding, bending and bonding': polypurine tract-primed initiation of plus-strand DNA synthesis in human immunodeficiency virus.
The international journal of biochemistry & cell biology 2004;36(9):1752-66.
2004: Chan King C; Budihas Scott R; Le Grice Stuart F J; Parniak Michael A; Crouch Robert J; Gaidamakov Sergei A; Isaaq Haleem J; Wamiru Antony; McMahon James B; Beutler John A
A capillary electrophoretic assay for ribonuclease H activity.
Analytical biochemistry 2004;331(2):296-302.
2004: Dash Chandravanu; Yi-Brunozzi Hye-Young; Le Grice Stuart F J
Two modes of HIV-1 polypurine tract cleavage are affected by introducing locked nucleic acid analogs into the (-) DNA template.
The Journal of biological chemistry 2004;279(35):37095-102.
2004: Sitaraman Kalavathy; Esposito Dominic; Klarmann George; Le Grice Stuart F; Hartley James L; Chatterjee Deb K
A novel cell-free protein synthesis system.
Journal of biotechnology 2004;110(3):257-63.
2004: Shkriabai Nick; Patil Sachindra S; Hess Sonja; Budihas Scott R; Craigie Robert; Burke Terrence R; Le Grice Stuart F J; Kvaratskhelia Mamuka
Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):6894-9.
2004: Miller Jennifer T; Khvorova Anastasia; Scaringe Stephen A; Le Grice Stuart F J
Synthetic tRNALys,3 as the replication primer for the HIV-1HXB2 and HIV-1Mal genomes.
Nucleic acids research 2004;32(15):4687-95.
2004: Dash Chandravanu; Rausch Jason W; Le Grice Stuart F J
Using pyrrolo-deoxycytosine to probe RNA/DNA hybrids containing the human immunodeficiency virus type-1 3' polypurine tract.
Nucleic acids research 2004;32(4):1539-47.
2003: Le Grice Stuart F J
"In the beginning": initiation of minus strand DNA synthesis in retroviruses and LTR-containing retrotransposons.
Biochemistry 2003;42(49):14349-55.
2003: Parniak Michael A; Min Kyung-Lyum; Budihas Scott R; Le Grice Stuart F J; Beutler John A
A fluorescence-based high-throughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity.
Analytical biochemistry 2003;322(1):33-9.
2003: Rausch Jason W; Qu Jin; Yi-Brunozzi Hye Young; Kool Eric T; Le Grice Stuart F J
Hydrolysis of RNA/DNA hybrids containing nonpolar pyrimidine isosteres defines regions essential for HIV type 1 polypurine tract selection.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11279-84.
2003: Roda Ricardo H; Balakrishnan Mini; Hanson Mark N; Wohrl Birgitta M; Le Grice Stuart F J; Roques Bernard P; Gorelick Robert J; Bambara Robert A
Role of the Reverse Transcriptase, Nucleocapsid Protein, and Template Structure in the Two-step Transfer Mechanism in Retroviral Recombination.
The Journal of biological chemistry 2003;278(34):31536-46.
2003: Post Klara; Guo Jianhui; Howard Kathryn J; Powell Michael D; Miller Jennifer T; Hizi Amnon; Le Grice Stuart F J; Levin Judith G
Human immunodeficiency virus type 2 reverse transcriptase activity in model systems that mimic steps in reverse transcription.
Journal of virology 2003;77(13):7623-34.
2003: Lener Daniela; Kvaratskhelia Mamuka; Le Grice Stuart F J
Nonpolar thymine isosteres in the Ty3 polypurine tract DNA template modulate processing and provide a model for its recognition by Ty3 reverse transcriptase.
The Journal of biological chemistry 2003;278(29):26526-32.
2003: Rigourd Mickaël; Bec Guillaume; Bénas Philippe; Le Grice Stuart F J; Ehresmann Bernard; Ehresmann Chantal; Marquet Roland
Effects of tRNA 3 Lys aminoacylation on the initiation of HIV-1 reverse transcription.
Biochimie 2003;85(5):521-5.
2002: Kvaratskhelia Mamuka; Miller Jennifer T; Budihas Scott R; Pannell Lewis K; Le Grice Stuart F J
Identification of specific HIV-1 reverse transcriptase contacts to the viral RNA:tRNA complex by mass spectrometry and a primary amine selective reagent.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(25):15988-93.
2002: Goldschmidt Valerie; Rigourd Mickael; Ehresmann Chantal; Le Grice Stuart F J; Ehresmann Bernard; Marquet Roland
Direct and indirect contributions of RNA secondary structure elements to the initiation of HIV-1 reverse transcription.
The Journal of biological chemistry 2002;277(45):43233-42.
2002: Klarmann George J; Hawkins Mary E; Le Grice Stuart F J
Uncovering the complexities of retroviral ribonuclease H reveals its potential as a therapeutic target.
AIDS reviews 2002;4(4):183-94.
2002: Cristofaro Jason V; Rausch Jason W; Le Grice Stuart F J; DeStefano Jeffrey J
Mutations in the ribonuclease H active site of HIV-RT reveal a role for this site in stabilizing enzyme-primer-template binding.
Biochemistry 2002;41(36):10968-75.
2002: Lener Daniela; Budihas Scott R; Le Grice Stuart F J
Mutating conserved residues in the ribonuclease H domain of Ty3 reverse transcriptase affects specialized cleavage events.
The Journal of biological chemistry 2002;277(29):26486-95.
2002: Kvaratskhelia Mamuka; Budihas Scott R; Le Grice Stuart F J
Pre-existing distortions in nucleic acid structure aid polypurine tract selection by HIV-1 reverse transcriptase.
The Journal of biological chemistry 2002;277(19):16689-96.
2002: Moscardini Mila; Pistello Mauro; Bendinelli M; Ficheux Damien; Miller Jennifer T; Gabus Caroline; Le Grice Stuart F J; Surewicz Witold K; Darlix Jean-Luc
Functional interactions of nucleocapsid protein of feline immunodeficiency virus and cellular prion protein with the viral RNA.
Journal of molecular biology 2002;318(1):149-59.
2002: Rausch Jason W; Lener Daniela; Miller Jennifer T; Julias John G; Hughes Stephen H; Le Grice Stuart F J
Altering the RNase H primer grip of human immunodeficiency virus reverse transcriptase modifies cleavage specificity.
Biochemistry 2002;41(15):4856-65.
2002: Nymark-McMahon M Henrietta; Beliakova-Bethell Nadejda S; Darlix Jean-Luc; Le Grice Stuart F J; Sandmeyer Suzanne B
Ty3 integrase is required for initiation of reverse transcription.
Journal of virology 2002;76(6):2804-16.
2002: Brulé Fabienne; Marquet Roland; Rong Liwei; Wainberg Mark A; Roques Bernard P; Le Grice Stuart F J; Ehresmann Bernard; Ehresmann Chantal
Structural and functional properties of the HIV-1 RNA-tRNA(Lys)3 primer complex annealed by the nucleocapsid protein: comparison with the heat-annealed complex.
RNA (New York, N.Y.) 2002;8(1):8-15.
2001: Miller J T; Ehresmann B; Hübscher U; Le Grice S F
A novel interaction of tRNA(Lys,3) with the feline immunodeficiency virus RNA genome governs initiation of minus strand DNA synthesis.
The Journal of biological chemistry 2001;276(29):27721-30.
2001: Gorshkova I I; Rausch J W; Le Grice S F; Crouch R J
HIV-1 reverse transcriptase interaction with model RNA-DNA duplexes.
Analytical biochemistry 2001;291(2):198-206.
2001: Miller J T; Rausch J W; Le Grice S F
Evaluation of retroviral ribonuclease H activity.
Methods in molecular biology (Clifton, N.J.) 2001;160():335-54.
2000: Rigourd M; Lanchy J M; Le Grice S F; Ehresmann B; Ehresmann C; Marquet R
Inhibition of the initiation of HIV-1 reverse transcription by 3'-azido-3'-deoxythymidine. Comparison with elongation.
The Journal of biological chemistry 2000;275(35):26944-51.
2000: Rausch J W; Grice M K; Henrietta M; Nymark-McMahon; Miller J T; Le Grice S F
Interaction of p55 reverse transcriptase from the Saccharomyces cerevisiae retrotransposon Ty3 with conformationally distinct nucleic acid duplexes.
The Journal of biological chemistry 2000;275(18):13879-87.
2000: Rausch J W; Sathyanarayana B K; Bona M K; Le Grice S F
Probing contacts between the ribonuclease H domain of HIV-1 reverse transcriptase and nucleic acid by site-specific photocross-linking.
The Journal of biological chemistry 2000;275(21):16015-22.
2000: Lanchy J M; Isel C; Keith G; Le Grice S F; Ehresmann C; Ehresmann B; Marquet R
Dynamics of the HIV-1 reverse transcription complex during initiation of DNA synthesis.
The Journal of biological chemistry 2000;275(16):12306-12.
2000: Cowan J A; Ohyama T; Howard K; Rausch J W; Cowan S M; Le Grice S F
Metal-ion stoichiometry of the HIV-1 RT ribonuclease H domain: evidence for two mutually exclusive sites leads to new mechanistic insights on metal-mediated hydrolysis in nucleic acid biochemistry.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(1):67-74.
2000: Brulé F; Bec G; Keith G; Le Grice S F; Roques B P; Ehresmann B; Ehresmann C; Marquet R
In vitro evidence for the interaction of tRNA(3)(Lys) with U3 during the first strand transfer of HIV-1 reverse transcription.
Nucleic acids research 2000;28(2):634-40.
1999: Cristofari G; Gabus C; Ficheux D; Bona M; Le Grice S F; Darlix J L
Characterization of active reverse transcriptase and nucleoprotein complexes of the yeast retrotransposon Ty3 in vitro.
The Journal of biological chemistry 1999;274(51):36643-8.
1999: Wisniewski M; Palaniappan C; Fu Z; Le Grice S F; Fay P; Bambara R A
Mutations in the primer grip region of HIV reverse transcriptase can increase replication fidelity.
The Journal of biological chemistry 1999;274(40):28175-84.
1999: Powell M D; Beard W A; Bebenek K; Howard K J; Le Grice S F; Darden T A; Kunkel T A; Wilson S H; Levin J G
Residues in the alphaH and alphaI helices of the HIV-1 reverse transcriptase thumb subdomain required for the specificity of RNase H-catalyzed removal of the polypurine tract primer.
The Journal of biological chemistry 1999;274(28):19885-93.
1999: Stetor S R; Rausch J W; Guo M J; Burnham J P; Boone L R; Waring M J; Le Grice S F
Characterization of (+) strand initiation and termination sequences located at the center of the equine infectious anemia virus genome.
Biochemistry 1999;38(12):3656-67.
1999: Isel C; Westhof E; Massire C; Le Grice S F; Ehresmann B; Ehresmann C; Marquet R
Structural basis for the specificity of the initiation of HIV-1 reverse transcription.
The EMBO journal 1999;18(4):1038-48.
1999: Auxilien S; Keith G; Le Grice S F; Darlix J L
Role of post-transcriptional modifications of primer tRNALys,3 in the fidelity and efficacy of plus strand DNA transfer during HIV-1 reverse transcription.
The Journal of biological chemistry 1999;274(7):4412-20.
1998: Lener D; Tanchou V; Roques B P; Le Grice S F; Darlix J L
Involvement of HIV-I nucleocapsid protein in the recruitment of reverse transcriptase into nucleoprotein complexes formed in vitro.
The Journal of biological chemistry 1998;273(50):33781-6.
1998: Lanchy J M; Keith G; Le Grice S F; Ehresmann B; Ehresmann C; Marquet R
Contacts between reverse transcriptase and the primer strand govern the transition from initiation to elongation of HIV-1 reverse transcription.
The Journal of biological chemistry 1998;273(38):24425-32.
1998: Arts E J; Miller J T; Ehresmann B; Le Grice S F
Mutating a region of HIV-1 reverse transcriptase implicated in tRNA(Lys-3) binding and the consequences for (-)-strand DNA synthesis.
The Journal of biological chemistry 1998;273(23):14523-32.
1998: Arts E J; Le Grice S F
Interaction of retroviral reverse transcriptase with template-primer duplexes during replication.
Progress in nucleic acid research and molecular biology 1998;58():339-93.
1997: Ghosh M; Williams J; Powell M D; Levin J G; Le Grice S F
Mutating a conserved motif of the HIV-1 reverse transcriptase palm subdomain alters primer utilization.
Biochemistry 1997;36(19):5758-68.
1997: Powell M D; Ghosh M; Jacques P S; Howard K J; Le Grice S F; Levin J G
Alanine-scanning mutations in the "primer grip" of p66 HIV-1 reverse transcriptase result in selective loss of RNA priming activity.
The Journal of biological chemistry 1997;272(20):13262-9.
1997: Palaniappan C; Wisniewski M; Jacques P S; Le Grice S F; Fay P J; Bambara R A
Mutations within the primer grip region of HIV-1 reverse transcriptase result in loss of RNase H function.
The Journal of biological chemistry 1997;272(17):11157-64.
1997: Rausch J W; Le Grice S F
Substituting a conserved residue of the ribonuclease H domain alters substrate hydrolysis by retroviral reverse transcriptase.
The Journal of biological chemistry 1997;272(13):8602-10.
1996: Lanchy J M; Ehresmann C; Le Grice S F; Ehresmann B; Marquet R
Binding and kinetic properties of HIV-1 reverse transcriptase markedly differ during initiation and elongation of reverse transcription.
The EMBO journal 1996;15(24):7178-87.
1996: Le Grice S F; Whalen C C; Hom D L; Lehmann P V; Walker C J
Perspective: research highlights at the Case Western Reserve University Center for AIDS Research. Learning from the past and looking toward the future.
AIDS research and human retroviruses 1996;12(18):1659-66.
1996: Yusupova G; Lanchy J M; Yusupov M; Keith G; Le Grice S F; Ehresmann C; Ehresmann B; Marquet R
Primer selection by HIV-1 reverse transcriptase on RNA-tRNA(3Lys) and DNA-tRNA(3Lys) hybrids.
Journal of molecular biology 1996;261(3):315-21.
1996: Ghosh M; Jacques P S; Rodgers D W; Ottman M; Darlix J L; Le Grice S F
Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization.
Biochemistry 1996;35(26):8553-62.
1996: Rausch J W; Arts E J; Wöhrl B M; Le Grice S F
Involvement of C-terminal structural elements of equine infectious anemia virus reverse transcriptase in DNA polymerase and ribonuclease H activities.
Journal of molecular biology 1996;257(3):500-11.
1996: Arts E J; Ghosh M; Jacques P S; Ehresmann B; Le Grice S F
Restoration of tRNA3Lys-primed(-)-strand DNA synthesis to an HIV-1 reverse transcriptase mutant with extended tRNAs. Implications for retroviral replication.
The Journal of biological chemistry 1996;271(15):9054-61.
1996: Isel C; Lanchy J M; Le Grice S F; Ehresmann C; Ehresmann B; Marquet R
Specific initiation and switch to elongation of human immunodeficiency virus type 1 reverse transcription require the post-transcriptional modifications of primer tRNA3Lys.
The EMBO journal 1996;15(4):917-24.
1996: Arts E J; Marois J P; Gu Z; Le Grice S F; Wainberg M A
Effects of 3'-deoxynucleoside 5'-triphosphate concentrations on chain termination by nucleoside analogs during human immunodeficiency virus type 1 reverse transcription of minus-strand strong-stop DNA.
Journal of virology 1996;70(2):712-20.
1995: Cirino N M; Cameron C E; Smith J S; Rausch J W; Roth M J; Benkovic S J; Le Grice S F
Divalent cation modulation of the ribonuclease functions of human immunodeficiency virus reverse transcriptase.
Biochemistry 1995;34(31):9936-43.
1995: Wöhrl B M; Tantillo C; Arnold E; Le Grice S F
An expanded model of replicating human immunodeficiency virus reverse transcriptase.
Biochemistry 1995;34(16):5343-56.
1995: Ghosh M; Howard K J; Cameron C E; Benkovic S J; Hughes S H; Le Grice S F
Truncating alpha-helix E' of p66 human immunodeficiency virus reverse transcriptase modulates RNase H function and impairs DNA strand transfer.
The Journal of biological chemistry 1995;270(13):7068-76.
1995: Wöhrl B M; Georgiadis M M; Telesnitsky A; Hendrickson W A; Le Grice S F
Footprint analysis of replicating murine leukemia virus reverse transcriptase.
Science (New York, N.Y.) 1995;267(5194):96-9.
1995: Le Grice S F; Cameron C E; Benkovic S J
Purification and characterization of human immunodeficiency virus type 1 reverse transcriptase.
Methods in enzymology 1995;262():130-44.
1994: Jacques P S; Wöhrl B M; Ottmann M; Darlix J L; Le Grice S F
Mutating the "primer grip" of p66 HIV-1 reverse transcriptase implicates tryptophan-229 in template-primer utilization.
The Journal of biological chemistry 1994;269(42):26472-8.
1994: Wöhrl B M; Howard K J; Jacques P S; Le Grice S F
Alternative modes of polymerization distinguish the subunits of equine infectious anemia virus reverse transcriptase.
The Journal of biological chemistry 1994;269(11):8541-8.
1994: Jacques P S; Wöhrl B M; Howard K J; Le Grice S F
Modulation of HIV-1 reverse transcriptase function in "selectively deleted" p66/p51 heterodimers.
The Journal of biological chemistry 1994;269(2):1388-93.
1993: Cirino N M; Kalayjian R C; Jentoft J E; Le Grice S F
Fluorimetric analysis of recombinant p15 HIV-1 ribonuclease H.
The Journal of biological chemistry 1993;268(20):14743-9.
1993: Wöhrl B M; Ehresmann B; Keith G; Le Grice S F
Nuclease footprinting of human immunodeficiency virus reverse transcriptase/tRNA(Lys-3) complexes.
The Journal of biological chemistry 1993;268(18):13617-24.
1993: Threadgill D S; Steagall W K; Flaherty M T; Fuller F J; Perry S T; Rushlow K E; Le Grice S F; Payne S L
Characterization of equine infectious anemia virus dUTPase: growth properties of a dUTPase-deficient mutant.
Journal of virology 1993;67(5):2592-600.
1993: DeVico A L; Issel C J; Le Grice S F; Payne S L; Montelaro R C; Sarngadharan M G
High prevalence of serum antibodies to equine infectious anemia virus reverse transcriptase.
AIDS research and human retroviruses 1993;9(1):7-11.
1992: Richter-Cook N J; Howard K J; Cirino N M; Wöhrl B M; Le Grice S F
Interaction of tRNA(Lys-3) with multiple forms of human immunodeficiency virus reverse transcriptase.
The Journal of biological chemistry 1992;267(22):15952-7.
1991: Howard K J; Frank K B; Sim I S; Le Grice S F
Reconstitution and properties of homologous and chimeric HIV-1.HIV-2 p66.p51 reverse transcriptase.
The Journal of biological chemistry 1991;266(34):23003-9.
1991: Le Grice S F; Panin M; Kalayjian R C; Richter N J; Keith G; Darlix J L; Payne S L
Purification and characterization of recombinant equine infectious anemia virus reverse transcriptase.
Journal of virology 1991;65(12):7004-7.

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