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Yannick Le Marchand-Brustel

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Nancy Zaarour; Yannick Le Marchand-Brustel; Marion Berenguer; Roland Govers
Deciphering the role of GLUT4 N-glycosylation in adipocyte and muscle cell models.
Claire Regazzetti; Jean-François Tanti; Karine Dumas; Yannick Le Marchand-Brustel; Pascal Peraldi; Sophie Giorgetti-Peraldi
Regulated in development and DNA damage responses -1 (REDD1) protein contributes to insulin signaling pathway in adipocytes.
Stéphanie Patouraux; Gabriel Perlemuter; Maria Alessandra Rosenthal-Allieri; Marie-Christine Saint-Paul; Albert Tran; Pascal Veillon; Cosmin S Voican; Hélène Agostini; Rodolphe Anty; Nadége Barri-Ova; Stéphanie Bonnafous; Paul Calès; Yannick Le Marchand-Brustel; Sylvie Naveau; Micheline Njike; Philippe Gual
The osteopontin level in liver, adipose tissue and serum is correlated with fibrosis in patients with alcoholic liver disease.

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2012: Nancy Zaarour; Yannick Le Marchand-Brustel; Marion Berenguer; Roland Govers
Deciphering the role of GLUT4 N-glycosylation in adipocyte and muscle cell models.
The Biochemical journal 2012;445(2):265-73.
2012: Claire Regazzetti; Jean-François Tanti; Karine Dumas; Yannick Le Marchand-Brustel; Pascal Peraldi; Sophie Giorgetti-Peraldi
Regulated in development and DNA damage responses -1 (REDD1) protein contributes to insulin signaling pathway in adipocytes.
PloS one 2012;7(12):e52154.
2012: Stéphanie Patouraux; Gabriel Perlemuter; Maria Alessandra Rosenthal-Allieri; Marie-Christine Saint-Paul; Albert Tran; Pascal Veillon; Cosmin S Voican; Hélène Agostini; Rodolphe Anty; Nadége Barri-Ova; Stéphanie Bonnafous; Paul Calès; Yannick Le Marchand-Brustel; Sylvie Naveau; Micheline Njike; Philippe Gual
The osteopontin level in liver, adipose tissue and serum is correlated with fibrosis in patients with alcoholic liver disease.
PloS one 2012;7(4):e35612.
2011: Esther Zimmermann; Yannick Le Marchand-Brustel; Thorkild I A Sørensen; Joan Tordjman; Albert Tran; Luc Van Gaal; An Verrijken; Rodolphe Anty; Pierre Bedossa; Karine Clement; Sven Francque; Philippe Gual; Jean Gugenheim; Antonio Iannelli; Tine Jess
C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients.
Journal of hepatology 2011;55(3):660-5.
2011: Isaam Ben Sahra; Patrick Auberger; Sophie Giorgetti-Peraldi; Kathiane Laurent; Yannick Le Marchand-Brustel; Claire Regazzetti; Guillaume ROBERT; Jean-François Tanti; Frédéric Bost
Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.
Cancer research 2011;71(13):4366-72.
2011: Marion Berenguer; Jinzhong Zhang; M Christine Bruce; Laurène Martinez; Teresa Gonzalez; Andrey A Gurtovenko; Tao Xu; Yannick Le Marchand-Brustel; Roland Govers
Dimethyl sulfoxide enhances GLUT4 translocation through a reduction in GLUT4 endocytosis in insulin-stimulated 3T3-L1 adipocytes.
Biochimie 2011;93(4):697-709.
2011: Vanessa Jeannette Lavallard; Stéphanie Bonnafous; Stéphanie Patouraux; Marie-Christine Saint-Paul; Déborah Rousseau; Rodolphe Anty; Yannick Le Marchand-Brustel; Albert Tran; Philippe Gual
Serum markers of hepatocyte death and apoptosis are non invasive biomarkers of severe fibrosis in patients with alcoholic liver disease.
PloS one 2011;6(3):e17599.
2011: Jennifer Jager; V Corcelle; Thierry Grémeaux; K Laurent; A Waget; G Pagès; B Binétruy; Yannick Le Marchand-Brustel; R Burcelin; F Bost; J F Tanti
Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity.
Diabetologia 2011;54(1):180-9.
2010: Rodolphe Anty; Antonio Iannelli; S Patouraux; Stéphanie Bonnafous; V J Lavallard; M Senni-Buratti; I Ben Amor; A Staccini-Myx; Marie-Christine Saint-Paul; F Berthier; Pierre-Michel Huet; Yannick Le Marchand-Brustel; Jean Gugenheim; Philippe Gual; Albert Tran
A new composite model including metabolic syndrome, alanine aminotransferase and cytokeratin-18 for the diagnosis of non-alcoholic steatohepatitis in morbidly obese patients.
Alimentary pharmacology & therapeutics 2010;32(11-12):1315-22.
2010: Jonathan Barr; Mercedes vázquez-chantada; Cristina Alonso; Miriam Pérez-Cormenzana; Rebeca Mayo; Asier Galán; Juan Caballería; Antonio Martín-Duce; Albert Tran; Conrad Wagner; Zigmund Luka; Shelly C Lu; Azucena Castro; Yannick Le Marchand-Brustel; M Luz Martínez-Chantar; nicolas veyrie; Karine Clément; Joan Tordjman; Philippe Gual; José M Mato
Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease.
Journal of proteome research 2010;9(9):4501-12.
2010: Issam Ben Sahra; Yannick Le Marchand-Brustel; Jean-François Tanti; Frédéric Bost
Metformin in cancer therapy: a new perspective for an old antidiabetic drug?
Molecular cancer therapeutics 2010;9(5):1092-9.
2010: Laurène Martinez; Marion Berenguer; M Christine Bruce; Yannick Le Marchand-Brustel; Roland Govers
Rosiglitazone increases cell surface GLUT4 levels in 3T3-L1 adipocytes through an enhancement of endosomal recycling.
Biochemical pharmacology 2010;79(9):1300-9.
2010: Issam Ben Sahra; Kathiane Laurent; Sandy Giuliano; Frédéric Larbret; Gilles Ponzio; Pierre GOUNON; Yannick Le Marchand-Brustel; Sophie Giorgetti-Peraldi; Mireille Cormont; Corine Bertolotto; Marcel Deckert; Patrick Auberger; Jean-François Tanti; Frédéric Bost
Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells.
Cancer research 2010;70(6):2465-75.
2010: Claire Regazzetti; Frédéric Bost; Yannick Le Marchand-Brustel; Jean-François Tanti; Sophie Giorgetti-Peraldi
Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes.
The Journal of biological chemistry 2010;285(8):5157-64.
2010: Marion Berenguer; Yannick Le Marchand-Brustel; Roland Govers
GLUT4 molecules are recruited at random for insertion within the plasma membrane upon insulin stimulation.
FEBS letters 2010;584(3):537-42.
2010: Marion Berenguer; Laurène Martinez; Sophie Giorgetti-Peraldi; Yannick Le Marchand-Brustel; Roland Govers
A serum factor induces insulin-independent translocation of GLUT4 to the cell surface which is maintained in insulin resistance.
PloS one 2010;5(12):e15560.
2010: Adeline Bertola; Stéphanie Bonnafous; Rodolphe Anty; Stéphanie Patouraux; Marie-Christine Saint-Paul; Antonio Iannelli; Jean Gugenheim; Jonathan Barr; José M Mato; Yannick Le Marchand-Brustel; Albert Tran; Philippe Gual
Hepatic expression patterns of inflammatory and immune response genes associated with obesity and NASH in morbidly obese patients.
PloS one 2010;5(10):e13577.
2010: Jennifer Jager; Thierry Grémeaux; Teresa Gonzalez; Stéphanie Bonnafous; Cyrille Debard; Martine Laville; Hubert Vidal; Albert Tran; Philippe Gual; Yannick Le Marchand-Brustel; Mireille Cormont; Jean-François Tanti
Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.
Diabetes 2010;59(1):61-70.
2009: Valérie Risson; Laetitia Mazelin; Mila Roceri; Hervé Sanchez; Vincent Moncollin; Claudine Corneloup; Hélène Richard-Bulteau; Alban Vignaud; Dominique Baas; Aurélia Defour; Damien Freyssenet; Jean-François Tanti; Yannick Le Marchand-Brustel; Bernard Ferrier; Agnès Conjard-Duplany; Klaas Romanino; Stéphanie Bauché; Daniel Hantaï; Matthias Mueller; Sara C Kozma; George Thomas; Markus A Rüegg; Arnaud Ferry; Mario Pende; Xavier Bigard; Nathalie Koulmann; Laurent Schaeffer; Yann-Gaël Gangloff
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.
The Journal of cell biology 2009;187(6):859-74.
2009: Vincent Kaddai; Teresa Gonzalez; Frédérique Keslair; Thierry Grémeaux; Stéphanie Bonnafous; Jean Gugenheim; Albert Tran; Philippe Gual; Yannick Le Marchand-Brustel; Mireille Cormont
Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte.
PloS one 2009;4(4):e5257.
2009: Vanessa Deveaux; Thomas Cadoudal; Yasukatsu Ichigotani; Fatima Teixeira-Clerc; Alexandre Louvet; Sylvie Manin; Jeanne Tran Van Nhieu; Marie Pierre Belot; Andreas Zimmer; Patrick Even; Patrice D Cani; Claude Knauf; Remy Burcelin; Adeline Bertola; Yannick Le Marchand-Brustel; Philippe Gual; Ariane Mallat; Sophie Lotersztajn
Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis.
PloS one 2009;4(6):e5844.
2009: Claire Regazzetti; Pascal Peraldi; Thierry Grémeaux; Rosanna Najem-Lendom; Issam Ben-Sahra; Mireille Cormont; Frédéric Bost; Yannick Le Marchand-Brustel; Jean-François Tanti; Sophie Giorgetti-Peraldi
Hypoxia decreases insulin signaling pathways in adipocytes.
Diabetes 2009;58(1):95-103.
2009: Adeline Bertola; Vanessa Deveaux; Stéphanie Bonnafous; Déborah Rousseau; Rodolphe Anty; Abdelilah Wakkach; Moncef Dahman; Joan Tordjman; Karine Clément; Siobhán E McQuaid; Keith N Frayn; Pierre-Michel Huet; Jean Gugenheim; Sophie Lotersztajn; Yannick Le Marchand-Brustel; Albert Tran; Philippe Gual
Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity.
Diabetes 2009;58(1):125-33.
2008: Rodolphe Anty; Monsef Dahman; Antonio Iannelli; Philippe Gual; Aline Staccini-Myx; Imed Ben Amor; Nathalie Luciani; Marie-Christine Saint-Paul; Pierre-Michel Huet; Jean-Louis Sadoul; Kaila Surjit Srai; Robert Unwin; Jean Gugenheim; Yannick Le Marchand-Brustel; Albert Tran; Soumeya Bekri
Bariatric surgery can correct iron depletion in morbidly obese women: a link with chronic inflammation.
Obesity surgery 2008;18(6):709-14.
2008: Vincent Kaddai; Yannick Le Marchand-Brustel; Mireille Cormont
Rab proteins in endocytosis and Glut4 trafficking.
Acta physiologica (Oxford, England) 2008;192(1):75-88.
2007: Myriam Aouadi; Jennifer Jager; Kathiane Laurent; Teresa Gonzalez; Mireille Cormont; Bernard Binétruy; Yannick Le Marchand-Brustel; Jean-François Tanti; Frédéric Bost
p38MAP Kinase activity is required for human primary adipocyte differentiation.
FEBS letters 2007;581(29):5591-6.
2007: Adeline Bertola; Stéphanie Bonnafous; Mireille Cormont; Rodolphe Anty; Jean-François Tanti; Albert Tran; Yannick Le Marchand-Brustel; Philippe Gual
Hepatocyte growth factor induces glucose uptake in 3T3-L1 adipocytes through A Gab1/phosphatidylinositol 3-kinase/Glut4 pathway.
The Journal of biological chemistry 2007;282(14):10325-32.
2007: Philippe Gual; Teresa Gonzalez; Thierry Gremeaux; Yannick Le Marchand-Brustel; Jean-François Tanti
Osmotic regulation of cellular glucose uptake.
Methods in enzymology 2007;428():343-54.
2007: Jennifer Jager; Thierry Grémeaux; Mireille Cormont; Yannick Le Marchand-Brustel; Jean-François Tanti
Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression.
Endocrinology 2007;148(1):241-51.
2006: Matthieu Prot; Laurence Heripret; Nathalie Cardot-Leccia; Christophe Perrin; Myriam Aouadi; Thibaud Lavrut; Rodolphe Garraffo; Pierre Dellamonica; Jacques Durant; Yannick Le Marchand-Brustel; Bernard Binétruy
Long-term treatment with lopinavir-ritonavir induces a reduction in peripheral adipose depots in mice.
Antimicrobial agents and chemotherapy 2006;50(12):3998-4004.
2006: Jelena Vukmirica; Pascale Monzo; Yannick Le Marchand-Brustel; Mireille Cormont
The Rab4A effector protein Rabip4 is involved in migration of NIH 3T3 fibroblasts.
The Journal of biological chemistry 2006;281(47):36360-8.
2006: Romain Barrès; Thierry Grémeaux; Philippe Gual; Teresa Gonzalez; Jean Gugenheim; Albert Tran; Yannick Le Marchand-Brustel; Jean-François Tanti
Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation.
Molecular endocrinology (Baltimore, Md.) 2006;20(11):2864-75.
2006: Asnat Bloch-Damti; Ruth Potashnik; Philippe Gual; Yannick Le Marchand-Brustel; Jean-François Tanti; Assaf Rudich; Nava Bashan
Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress.
Diabetologia 2006;49(10):2463-73.
2006: Soumeya Bekri; Philippe Gual; Rodolphe Anty; Nathalie Luciani; Moucef Dahman; Bala Ramesh; Antonio Iannelli; Aline Staccini-Myx; Dominique Casanova; Imed Ben Amor; Marie-Christine Saint-Paul; Pierre-Michel Huet; Jean-Louis Sadoul; Jean Gugenheim; Kaila Surjit Srai; Albert Tran; Yannick Le Marchand-Brustel
Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH.
Gastroenterology 2006;131(3):788-96.
2006: Myriam Aouadi; B Binetruy; Leslie Caron; Yannick Le Marchand-Brustel; Frédéric Bost
Role of MAPKs in development and differentiation: lessons from knockout mice.
Biochimie 2006;88(9):1091-8.
2006: Rodolphe Anty; Soumeya Bekri; Nathalie Luciani; Marie-Christine Saint-Paul; Moucef Dahman; Antonio Iannelli; Imed Ben Amor; Aline Staccini-Myx; Pierre-Michel Huet; Jean Gugenheim; Jean-Louis Sadoul; Yannick Le Marchand-Brustel; Albert Tran; Philippe Gual
The inflammatory C-reactive protein is increased in both liver and adipose tissue in severely obese patients independently from metabolic syndrome, Type 2 diabetes, and NASH.
The American journal of gastroenterology 2006;101(8):1824-33.
2006: Myriam Aouadi; Frédéric Bost; Leslie Caron; Kathiane Laurent; Yannick Le Marchand-Brustel; Bernard Binétruy
p38 mitogen-activated protein kinase activity commits embryonic stem cells to either neurogenesis or cardiomyogenesis.
Stem cells (Dayton, Ohio) 2006;24(5):1399-406.
2006: Muriel Mari; Pascale Monzo; Vincent Kaddai; Frédérique Keslair; Teresa Gonzalez; Yannick Le Marchand-Brustel; Mireille Cormont
The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes.
Journal of cell science 2006;119(Pt 7):1297-306.
2006: Myriam Aouadi; Kathiane Laurent; Matthieu Prot; Yannick Le Marchand-Brustel; Bernard Binétruy; Frédéric Bost
Inhibition of p38MAPK increases adipogenesis from embryonic to adult stages.
Diabetes 2006;55(2):281-9.
2006: Yannick Le Marchand-Brustel; Philippe Gual; Myriam Aouadi; Thierry Grémeaux; Bernard Binétruy; Frédéric Bost; Jean-François Tanti
[Obesity, diabetes and insulin resistance. Alterations of insulin signalling].
Journal de la Société de biologie 2006;200(1):93-7.
2005: Romain Barrès; Teresa Gonzalez; Yannick Le Marchand-Brustel; Jean-François Tanti
The interaction between the adaptor protein APS and Enigma is involved in actin organisation.
Experimental cell research 2005;308(2):334-44.
2005: Pascale Monzo; Nils C Gauthier; Frédérique Keslair; Agnès Loubat; Christine M Field; Yannick Le Marchand-Brustel; Mireille Cormont
Clues to CD2-associated protein involvement in cytokinesis.
Molecular biology of the cell 2005;16(6):2891-902.
2005: Pascale Bardoux; Pili Zhang; Daisy Flamez; Anaïs Perilhou; Tiphaine Aguirre Lavin; Jean-François Tanti; Karine Hellemans; Emmanuel Gomas; Cécile Godard; Fabrizio Andreelli; Maria Antonietta Buccheri; Axel Kahn; Yannick Le Marchand-Brustel; Rémy Burcelin; Frans Schuit; Mireille Vasseur-Cognet
Essential role of chicken ovalbumin upstream promoter-transcription factor II in insulin secretion and insulin sensitivity revealed by conditional gene knockout.
Diabetes 2005;54(5):1357-63.
2005: Frédéric Bost; Myriam Aouadi; Leslie Caron; Patrick C Even; Nathalie Belmonte; Matthieu Prot; Christian Dani; Paul Hofman; Gilles Pagès; Jacques Pouysségur; Yannick Le Marchand-Brustel; Bernard Binétruy
The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis.
Diabetes 2005;54(2):402-11.
2005: Pascale Monzo; Muriel Mari; Vincent Kaddai; Teresa Gonzalez; Yannick Le Marchand-Brustel; Mireille Cormont
CD2AP, Rabip4, and Rabip4': analysis of interaction with Rab4a and regulation of endosomes morphology.
Methods in enzymology 2005;403():107-18.
2005: Philippe Gual; Yannick Le Marchand-Brustel; Jean-François Tanti
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
Biochimie 2005;87(1):99-109.
2004: Nicolas Boute; Vladimir Zilberfarb; Luc Camoin; S Bonnafous; Yannick Le Marchand-Brustel; Tarik Issad
The formation of an intrachain disulfide bond in the leptin protein is necessary for efficient leptin secretion.
Biochimie 2004;86(6):351-6.
2004: Jean-François Tanti; Philippe Gual; Thierry Grémeaux; Teresa Gonzalez; Romain Barrès; Yannick Le Marchand-Brustel
Alteration in insulin action: role of IRS-1 serine phosphorylation in the retroregulation of insulin signalling.
Annales d'endocrinologie 2004;65(1):43-8.
2003: Philippe Gual; Yannick Le Marchand-Brustel; Jean-François Tanti
Positive and negative regulation of glucose uptake by hyperosmotic stress.
Diabetes & metabolism 2003;29(6):566-75.
2003: Yannick Le Marchand-Brustel; Philippe Gual; Thierry Grémeaux; Teresa Gonzalez; Romain Barrès; Jean-François Tanti
Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling.
Biochemical Society transactions 2003;31(Pt 6):1152-6.
2003: Philippe Gual; Thierry Grémeaux; Teresa Gonzalez; Yannick Le Marchand-Brustel; Jean-François Tanti
MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632.
Diabetologia 2003;46(11):1532-42.
2003: Philippe Gual; Teresa Gonzalez; Thierry Grémeaux; Romain Barres; Yannick Le Marchand-Brustel; Jean-François Tanti
Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes.
The Journal of biological chemistry 2003;278(29):26550-7.
2003: Karim Bouzakri; Marina Roques; Philippe Gual; Sophie Espinosa; Fitsum Guebre-Egziabher; Jean-Paul Riou; Martine Laville; Yannick Le Marchand-Brustel; Jean-François Tanti; Hubert Vidal
Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes.
Diabetes 2003;52(6):1319-25.
2003: Mireille Cormont; Isidoro Metón; Muriel Mari; Pascale Monzo; Frédérique Keslair; Chantell Gaskin; Timothy E McGraw; Yannick Le Marchand-Brustel
CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl.
Traffic (Copenhagen, Denmark) 2003;4(2):97-112.
2002: Philippe Gual; Satoshi Shigematsu; Makoto Kanzaki; Thierry Grémeaux; Teresa Gonzalez; Jeffrey Pessin; Yannick Le Marchand-Brustel; Jean-François Tanti
A Crk-II/TC10 signaling pathway is required for osmotic shock-stimulated glucose transport.
The Journal of biological chemistry 2002;277(46):43980-6.
2002: Yannick Le Marchand-Brustel; Jean-François Tanti; Thierry Grémeaux; Jean-Marc Ricort
Molecular mechanism of insulin resistance.
Annales d'endocrinologie 2002;63(2 Pt 1):111-3.
2002: Frédéric Bost; Leslie Caron; Irène Marchetti; Christian Dani; Yannick Le Marchand-Brustel; Bernard Binétruy
Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage.
The Biochemical journal 2002;361(Pt 3):621-7.
2001: Muriel Mari; E Macia; Yannick Le Marchand-Brustel; Mireille Cormont
Role of the FYVE finger and the RUN domain for the subcellular localization of Rabip4.
The Journal of biological chemistry 2001;276(45):42501-8.
2001: Mireille Cormont; Yannick Le Marchand-Brustel
The role of small G-proteins in the regulation of glucose transport (review).
Molecular membrane biology 2001;18(3):213-20.
2001: Mireille Cormont; N Gautier; K Ilc; Yannick Le Marchand-Brustel
Expression of a prenylation-deficient Rab4 inhibits the GLUT4 translocation induced by active phosphatidylinositol 3-kinase and protein kinase B.
The Biochemical journal 2001;356(Pt 1):143-9.
2001: Mireille Cormont; Muriel Mari; Antoine Galmiche; Paul Hofman; Yannick Le Marchand-Brustel
A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1637-42.
2001: Serge Clément; U Krause; F Desmedt; Jean-François Tanti; Jens Behrends; Xavier Pesesse; T Sasaki; J Penninger; M Doherty; W Malaisse; Jacques E Dumont; Yannick Le Marchand-Brustel; Christophe Erneux; L Hue; Stéphane Schurmans
The lipid phosphatase SHIP2 controls insulin sensitivity.
Nature 2001;409(6816):92-7.
2001: Jean-François Tanti; Mireille Cormont; Thierry Grémeaux; Yannick Le Marchand-Brustel
Assays of glucose entry, glucose transporter amount, and translocation.
Methods in molecular biology (Clifton, N.J.) 2001;155():157-65.
2000: Mario Pende; Sara C Kozma; Muriel Jaquet; Viola Oorschot; Rémy Burcelin; Yannick Le Marchand-Brustel; Judith Klumperman; Bernard Thorens; George Thomas
Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice.
Nature 2000;408(6815):994-7.
2000: Sophie Grillo; Thierry Grémeaux; Antonio Casamayor; Dario R Alessi; Yannick Le Marchand-Brustel; Jean-François Tanti
Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1 potential involvement of src kinase.
European journal of biochemistry / FEBS 2000;267(22):6642-9.
1999: Sophie Grillo; Thierry Grémeaux; Yannick Le Marchand-Brustel; Jean-François Tanti
Potential role of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in insulin-stimulated glucose transporter 4 translocation in adipocytes.
FEBS letters 1999;461(3):277-9.
1999: Samir Attoub; S Levasseur; Marion Buyse; Hélène GOÏOT; Jean-Pierre Laigneau; Laurent Moizo; F Hervatin; Yannick Le Marchand-Brustel; J M Lewin; André Bado
Physiological role of cholecystokinin B/gastrin receptor in leptin secretion.
Endocrinology 1999;140(10):4406-10.
1999: Marc L Goalstone; J Wayne Leitner; Inga Golovchenko; M R Stjernholm; Mireille Cormont; Yannick Le Marchand-Brustel; Boris Draznin
Insulin promotes phosphorylation and activation of geranylgeranyltransferase II. Studies with geranylgeranylation of rab-3 and rab-4.
The Journal of biological chemistry 1999;274(5):2880-4.
1999: Yannick Le Marchand-Brustel
Molecular mechanisms of insulin action in normal and insulin-resistant states.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1999;107(2):126-32.
1999: Yannick Le Marchand-Brustel; Jean-François Tanti; Mireille Cormont; Jean-Marc Ricort; Thierry Grémeaux; Sophie Grillo
From insulin receptor signalling to Glut 4 translocation abnormalities in obesity and insulin resistance.
Journal of receptor and signal transduction research 1999;19(1-4):217-28.
1998: André Bado; S Levasseur; Samir Attoub; Stéphanie Kermorgant; Jean-Pierre Laigneau; M N Bortoluzzi; Laurent Moizo; Thérèse Lehy; Michèle Guerre-Millo; Yannick Le Marchand-Brustel; MJ Lewin
The stomach is a source of leptin.
Nature 1998;394(6695):790-3.
1997: P Vollenweider; Stuart S Martin; T Haruta; Andrew J Morris; JG Nelson; Mireille Cormont; Yannick Le Marchand-Brustel; David W Rose; Jerrold M Olefsky
The small guanosine triphosphate-binding protein Rab4 is involved in insulin-induced GLUT4 translocation and actin filament rearrangement in 3T3-L1 cells.
Endocrinology 1997;138(11):4941-9.
1997: Jean-Marc Ricort; Jean-François Tanti; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Cross-talk between the platelet-derived growth factor and the insulin signaling pathways in 3T3-L1 adipocytes.
The Journal of biological chemistry 1997;272(32):19814-8.
1997: Jean-François Tanti; Sophie Grillo; Thierry Grémeaux; P J Coffer; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes.
Endocrinology 1997;138(5):2005-10.
1997: C Henry; Jean-François Tanti; Thierry Grémeaux; C Morin; Emmanuel Van Obberghen; M Comet; Yannick Le Marchand-Brustel
Characterization of 6-deoxy-6-iodo-D-glucose: a potential new tool to assess glucose transport.
Nuclear medicine and biology 1997;24(1):99-104.
1996: Mireille Cormont; M N Bortoluzzi; N Gautier; M Mari; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes.
Molecular and cellular biology 1996;16(12):6879-86.
1996: Jean-François Tanti; Thierry Grémeaux; Sophie Grillo; V Calleja; A Klippel; L T Williams; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocation in adipocytes.
The Journal of biological chemistry 1996;271(41):25227-32.
1996: M N Bortoluzzi; Mireille Cormont; N Gautier; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
GTPase activating protein activity for Rab4 is enriched in the plasma membrane of 3T3-L1 adipocytes. Possible involvement in the regulation of Rab4 subcellular localization.
Diabetologia 1996;39(8):899-906.
1996: Mireille Cormont; Emmanuel Van Obberghen; M Zerial; Yannick Le Marchand-Brustel
Insulin induces a change in Rab5 subcellular localization in adipocytes independently of phosphatidylinositol 3-kinase activation.
Endocrinology 1996;137(8):3408-15.
1996: Antine Elaine Stenbit; R Burcelin; Ellen B Katz; Tsu-Shuen Tsao; N Gautier; Maureen J Charron; Yannick Le Marchand-Brustel
Diverse effects of Glut 4 ablation on glucose uptake and glycogen synthesis in red and white skeletal muscle.
The Journal of clinical investigation 1996;98(3):629-34.
1996: Jean-Marc Ricort; Jean-François Tanti; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes. A possible explanation for their specific effects on glucose transport.
European journal of biochemistry / FEBS 1996;239(1):17-22.
1996: D Jullien; S J Heydrick; N Gautier; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Effect of IGF-I on phosphatidylinositol 3-kinase in soleus muscle of lean and insulin-resistant obese mice.
Diabetes 1996;45(7):869-75.
1996: L A Sherman; Michael F Hirshman; Mireille Cormont; Yannick Le Marchand-Brustel; Laurie J Goodyear
Differential effects of insulin and exercise on Rab4 distribution in rat skeletal muscle.
Endocrinology 1996;137(1):266-73.
1995: Jean-Marc Ricort; Jean-François Tanti; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Alterations in insulin signalling pathway induced by prolonged insulin treatment of 3T3-L1 adipocytes.
Diabetologia 1995;38(10):1148-56.
1995: Yannick Le Marchand-Brustel; S J Heydrick; D Jullien; N Gautier; Emmanuel Van Obberghen
Effected of insulin and insulin-like growth factor-I on glucose transport and its transporters in soleus muscle of lean and obese mice.
Metabolism: clinical and experimental 1995;44(10 Suppl 4):18-23.
1995: Yannick Le Marchand-Brustel; N Gautier; Mireille Cormont; Emmanuel Van Obberghen
Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: comparison with fat cells.
Endocrinology 1995;136(8):3564-70.
1995: S J Heydrick; N Gautier; C Olichon-Berthe; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Early alteration of insulin stimulation of PI 3-kinase in muscle and adipocyte from gold thioglucose obese mice.
The American journal of physiology 1995;268(4 Pt 1):E604-12.
1995: Yannick Le Marchand-Brustel; S Heydrick; N Gautier; C Olichon-Berthe; Emmanuel Van Obberghen
[Development of insulin resistance in muscle and adipose tissue during obesity in the mouse. Role of phosphatidylinositol 3-kinase].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1995;():121-8.
1994: Jean-François Tanti; Thierry Grémeaux; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase.
The Biochemical journal 1994;304 ( Pt 1)():17-21.
1994: Jean-Marc Ricort; Jean-François Tanti; Mireille Cormont; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Parallel changes in Glut 4 and Rab4 movements in two insulin-resistant states.
FEBS letters 1994;347(1):42-4.
1994: Mireille Cormont; Jean-François Tanti; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Expression of guanine-nucleotide-binding proteins in lean and obese insulin-resistant mice.
Molecular and cellular endocrinology 1994;99(2):169-76.
1994: Jean-François Tanti; Thierry Grémeaux; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.
The Journal of biological chemistry 1994;269(8):6051-7.
1994: Mireille Cormont; Jean-François Tanti; Ahmed Zahraoui; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Rab4 is phosphorylated by the insulin-activated extracellular-signal-regulated kinase ERK1.
European journal of biochemistry / FEBS 1994;219(3):1081-5.
1994: C Olichon-Berthe; S Hauguel-De Mouzon; P Péraldi; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Insulin receptor dephosphorylation by phosphotyrosine phosphatases obtained from insulin-resistant obese mice.
Diabetologia 1994;37(1):56-60.
1993: Mireille Cormont; Jean-François Tanti; Ahmed Zahraoui; Emmanuel Van Obberghen; A Tavitian; Yannick Le Marchand-Brustel
Insulin and okadaic acid induce Rab4 redistribution in adipocytes.
The Journal of biological chemistry 1993;268(26):19491-7.
1993: D Jullien; Jean-François Tanti; S J Heydrick; N Gautier; Thierry Grémeaux; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and phosphatidylinositol 3-kinase activity.
The Journal of biological chemistry 1993;268(20):15246-51.
1993: Jean-François Tanti; Thierry Grémeaux; Mireille Cormont; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Okadaic acid stimulates IGF-II receptor translocation and inhibits insulin action in adipocytes.
The American journal of physiology 1993;264(6 Pt 1):E868-73.
1993: M J Duclos; Bernadette Chevalier; Yannick Le Marchand-Brustel; Jean-François Tanti; Chris Goddard; J Simon
Insulin-like growth factor-I-stimulated glucose transport in myotubes derived from chicken muscle satellite cells.
The Journal of endocrinology 1993;137(3):465-72.
1993: C Olichon-Berthe; N Gautier; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Expression of the glucose transporter GLUT4 in the muscular dystrophic mdx mouse.
The Biochemical journal 1993;291 ( Pt 1)():257-61.
1993: S J Heydrick; D Jullien; N Gautier; Jean-François Tanti; S Giorgetti; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice.
The Journal of clinical investigation 1993;91(4):1358-66.
1992: Jean-François Tanti; N Gautier; Mireille Cormont; V Baron; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Potential involvement of the carboxy-terminus of the Glut 1 transporter in glucose transport.
Endocrinology 1992;131(5):2319-24.
1992: C Olichon-Berthe; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Effect of cold acclimation on the expression of glucose transporter Glut 4.
Molecular and cellular endocrinology 1992;89(1-2):11-8.
1992: Mireille Cormont; T Gremeaux; Jean-François Tanti; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Polymyxin B inhibits insulin-induced glucose transporter and IGF II receptor translocation in isolated adipocytes.
European journal of biochemistry / FEBS 1992;207(1):185-93.
1991: Mireille Cormont; Jean-François Tanti; Thierry Grémeaux; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Subcellular distribution of low molecular weight guanosine triphosphate-binding proteins in adipocytes: colocalization with the glucose transporter Glut 4.
Endocrinology 1991;129(6):3343-50.
1991: Mireille Cormont; Yannick Le Marchand-Brustel; Emmanuel Van Obberghen; Allen Spiegel; Geoffrey W G Sharp
Identification of G protein alpha-subunits in RINm5F cells and their selective interaction with galanin receptor.
Diabetes 1991;40(9):1170-6.
1991: Jean-François Tanti; Thierry Grémeaux; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Effects of okadaic acid, an inhibitor of protein phosphatases-1 and -2A, on glucose transport and metabolism in skeletal muscle.
The Journal of biological chemistry 1991;266(4):2099-103.
1991: P Hainaut; A Kowalski; Yannick Le Marchand-Brustel; S Giorgetti; N Gautier; Emmanuel Van Obberghen
Effects of insulin, insulin-like growth factor-I (IGF-I) and progesterone on glucose and amino acid uptake in Xenopus laevis oocytes.
Molecular and cellular endocrinology 1991;75(2):133-9.
1990: Yannick Le Marchand-Brustel; C Olichon-Berthe; Thierry Grémeaux; Jean-François Tanti; N Rochet; Emmanuel Van Obberghen
Glucose transporter in insulin sensitive tissues of lean and obese mice. Effect of the thermogenic agent BRL 26830A.
Endocrinology 1990;127(6):2687-95.
1990: N Rochet; J L Sadoul; Bernard Ferrua; Joanna Kubar; Jean-François Tanti; P Bougnères; Bernard Vialettes; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel; P Freychet
Autoantibodies to the insulin receptor are infrequent findings in type 1 (insulin-dependent) diabetes mellitus of recent onset.
Diabetologia 1990;33(7):411-6.
1990: Yannick Le Marchand-Brustel; N Rochet; Thierry Grémeaux; I Marot; Emmanuel Van Obberghen
Effect of an alpha-glycosidase inhibitor on experimentally-induced obesity in mice.
Diabetologia 1990;33(1):24-30.
1989: Yannick Le Marchand-Brustel; Robert Ballotti; Thierry Grémeaux; Jean-François Tanti; D Brandenburg; Emmanuel Van Obberghen
Functional labeling of insulin receptor subunits in live cells. Alpha 2 beta 2 species is the major autophosphorylated form.
The Journal of biological chemistry 1989;264(35):21316-21.
1989: Geoffrey W G Sharp; Yannick Le Marchand-Brustel; T Yada; L L Russo; C R Bliss; Mireille Cormont; L Monge; Emmanuel Van Obberghen
Galanin can inhibit insulin release by a mechanism other than membrane hyperpolarization or inhibition of adenylate cyclase.
The Journal of biological chemistry 1989;264(13):7302-9.
1989: N Rochet; S Blanche; J C Carel; A Fischer; F L Deist; C Griscelli; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Hypoglycaemia induced by antibodies to insulin receptor following a bone marrow transplantation in an immunodeficient child.
Diabetologia 1989;32(3):167-72.
1989: Jean-François Tanti; N Rochet; Thierry Grémeaux; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Insulin-stimulated glucose transport in muscle. Evidence for a protein-kinase-C-dependent component which is unaltered in insulin-resistant mice.
The Biochemical journal 1989;258(1):141-6.
1989: Yannick Le Marchand-Brustel; Jean-François Tanti; N Rochet; Thierry Grémeaux; Emmanuel Van Obberghen
[Mechanisms of insulin resistance].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1989;():175-84.
1989: Robert Ballotti; Yannick Le Marchand-Brustel; S Gammeltoft; Emmanuel Van Obberghen
Insulin receptor: tyrosine kinase activity and insulin action.
Reproduction, nutrition, development 1989;29(6):653-61.
1988: N Rochet; Jean-François Tanti; Thierry Grémeaux; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Effect of a thermogenic agent, BRL 26830A, on insulin receptors in obese mice.
The American journal of physiology 1988;255(2 Pt 1):E101-9.
1987: Jean-François Tanti; Thierry Grémeaux; N Rochet; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Effect of cyclic AMP-dependent protein kinase on insulin receptor tyrosine kinase activity.
The Biochemical journal 1987;245(1):19-26.
1987: T Gremeaux; Jean-François Tanti; E Van Obberghen; Yannick Le Marchand-Brustel
Alteration of insulin receptor kinase in obese, insulin-resistant mice.
Biochimie 1987;69(4):387-93.
1987: A Debant; M Guerre-Millo; Yannick Le Marchand-Brustel; P Freychet; M Lavau; Emmanuel Van Obberghen
Insulin receptor kinase is hyperresponsive in adipocytes of young obese Zucker rats.
The American journal of physiology 1987;252(2 Pt 1):E273-8.
1987: Thierry Grémeaux; Jean-François Tanti; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Polymyxin B selectively inhibits insulin effects on transport in isolated muscle.
The American journal of physiology 1987;252(2 Pt 1):E248-54.
1986: Jean-François Tanti; Thierry Grémeaux; D Brandenburg; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Brown adipose tissue in lean and obese mice. Insulin-receptor binding and tyrosine kinase activity.
Diabetes 1986;35(11):1243-8.
1985: Emmanuel Van Obberghen; Robert Ballotti; H Gazzano; M Fehlmann; B Rossi; S Gammeltoft; A Debant; Yannick Le Marchand-Brustel; A Kowalski
The insulin receptor kinase.
Biochimie 1985;67(10-11):1119-24.
1985: Yannick Le Marchand-Brustel; Thierry Grémeaux; Robert Ballotti; Emmanuel Van Obberghen
Insulin receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice.
Nature 1985;315(6021):676-9.