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Derek Le Roith

Research Profile

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Publications

TOP 3
Yong Fan; Ramkumar Menon; Pinchas Cohen; David Hwang; Thomas Landes Clemens; Douglas J DiGirolamo; John J Kopchick; Derek Le Roith; Massimo Trucco; Mark A Sperling
Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism.
Emily Jane Gallagher; Derek Le Roith; Zachary Bloomgarden
Review of hemoglobin A(1c) in the management of diabetes.
Z T Bloomgarden; S E Inzucchi; E Karnieli; Derek Le Roith
The proposed terminology 'A(1c)-derived average glucose' is inherently imprecise and should not be adopted.

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All Publications

2009: Yong Fan; Ramkumar Menon; Pinchas Cohen; David Hwang; Thomas Landes Clemens; Douglas J DiGirolamo; John J Kopchick; Derek Le Roith; Massimo Trucco; Mark A Sperling
Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism.
The Journal of biological chemistry 2009;284(30):19937-44.
2009: Emily Jane Gallagher; Derek Le Roith; Zachary Bloomgarden
Review of hemoglobin A(1c) in the management of diabetes.
Journal of diabetes 2009;1(1):9-17.
2008: Z T Bloomgarden; S E Inzucchi; E Karnieli; Derek Le Roith
The proposed terminology 'A(1c)-derived average glucose' is inherently imprecise and should not be adopted.
Diabetologia 2008;51(7):1111-4.
2008: Espen E Spangenburg; Derek Le Roith; Christopher Ward; Sue Bodine
A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy.
The Journal of physiology 2008;586(1):283-91.
2007: Derek Le Roith
Insulin glargine and receptor-mediated signalling: clinical implications in treating type 2 diabetes.
Diabetes/metabolism research and reviews 2007;23(8):593-9.
2004: Martin Haluzik; Carlo Colombo; Oksana Gavrilova; Streamson Chua Jr.; Nicole Wolf; Min Chen; Bethel Stannard; Kelly R Dietz; Derek Le Roith; Marc L Reitman
Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice.
Endocrinology 2004;145(7):3258-64.
2004: Yuzhi Jia; Chao Qi; Papreddy Kashireddi; Sailesh Surapureddi; Yi-Jun Zhu; M Sambasiva Rao; Derek Le Roith; Pierre Chambon; Frank J Gonzalez; Janardan K Reddy
Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver.
The Journal of biological chemistry 2004;279(23):24427-34.
2004: Derek Le Roith
Molecular mechanisms by which metabolic control may improve outcomes.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2004;10 Suppl 2():57-62.
2004: Yiping Wu; Michael Karas; Joelle Dupont; Hong Zhao; Yuka Toyoshima; Derek Le Roith
Multiple signaling pathways are involved in the regulation of IGF-I receptor inhibition of PTEN-enhanced apoptosis.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2004;14(1):52-8.
2003: Derek Le Roith
The insulin-like growth factor system.
Experimental diabesity research 2003;4(4):205-12.
2002: Patricia Pennisi; Valarie Barr; Nomeli P Nunez; Bethel Stannard; Derek Le Roith
Reduced expression of insulin-like growth factor I receptors in MCF-7 breast cancer cells leads to a more metastatic phenotype.
Cancer research 2002;62(22):6529-37.
2002: Derek Le Roith; Hyunsook Kim; Ana M Fernandez; Domenici Accili
Inactivation of muscle insulin and IGF-I receptors and insulin responsiveness.
Current opinion in clinical nutrition and metabolic care 2002;5(4):371-5.
2002: Ana M Fernández; Joëlle Dupont; Roger P Farrar; Sukho Lee; Bethel Stannard; Derek Le Roith
Muscle-specific inactivation of the IGF-I receptor induces compensatory hyperplasia in skeletal muscle.
The Journal of clinical investigation 2002;109(3):347-55.
2001: A M Fernández; J K Kim; Shoshana Yakar; Joëlle Dupont; C Hernandez-Sanchez; A L Castle; J Filmore; G I Shulman; Derek Le Roith
Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes.
Genes & development 2001;15(15):1926-34.
2001: Joëlle Dupont; Derek Le Roith
Insulin-like growth factor 1 and oestradiol promote cell proliferation of MCF-7 breast cancer cells: new insights into their synergistic effects.
Molecular pathology : MP 2001;54(3):149-54.
2001: Shoshana Yakar; J L Liu; Ana M Fernandez; Yiping Wu; Andrew V Schally; Jan Frystyk; S D Chernausek; W Mejia; Derek Le Roith
Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity.
Diabetes 2001;50(5):1110-8.
2001: Derek Le Roith; Y Zick
Recent advances in our understanding of insulin action and insulin resistance.
Diabetes care 2001;24(3):588-97.
2001: Derek Le Roith; Louis Scavo; A Butler
What is the role of circulating IGF-I?
Trends in endocrinology and metabolism: TEM 2001;12(2):48-52.
2001: Derek Le Roith; Carolyn A Bondy; Shoshana Yakar; J L Liu; A Butler
The somatomedin hypothesis: 2001.
Endocrine reviews 2001;22(1):53-74.
2001: Derek Le Roith
Current therapeutic algorithms for type 2 diabetes.
Clinical cornerstone 2001;4(2):38-49.
2001: A A Butler; Derek Le Roith
Control of growth by the somatropic axis: growth hormone and the insulin-like growth factors have related and independent roles.
Annual review of physiology 2001;63():141-64.
2000: Shoshana Yakar; J L Liu; Derek Le Roith
The growth hormone/insulin-like growth factor-I system: implications for organ growth and development.
Pediatric nephrology (Berlin, Germany) 2000;14(7):544-9.
2000: Derek Le Roith
Regulation of proliferation and apoptosis by the insulin-like growth factor I receptor.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2000;10 Suppl A():S12-3.
1999: Derek Le Roith; A A Butler
Insulin-like growth factors in pediatric health and disease.
The Journal of clinical endocrinology and metabolism 1999;84(12):4355-61.
1999: Derek Le Roith; M Karas; Shoshana Yakar; B H Qu; Y Wu; VA Blakesley
The role of the insulin-like growth factors in cancer.
The Israel Medical Association journal : IMAJ 1999;1(1):25-30.
1998: Y Okubo; VA Blakesley; Bethel Stannard; J Silvio Gutkind; Derek Le Roith
Insulin-like growth factor-I inhibits the stress-activated protein kinase/c-Jun N-terminal kinase.
The Journal of biological chemistry 1998;273(40):25961-6.
1997: Derek Le Roith; Marcelina Parrizas; VA Blakesley
The insulin-like growth factor-I receptor and apoptosis. Implications for the aging progress.
Endocrine 1997;7(1):103-5.
1997: Marcelina Parrizas; VA Blakesley; D Beitner-Johnson; Derek Le Roith
The proto-oncogene Crk-II enhances apoptosis by a Ras-dependent, Raf-1/MAP kinase-independent pathway.
Biochemical and biophysical research communications 1997;234(3):616-20.
1997: Derek Le Roith
Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors.
The New England journal of medicine 1997;336(9):633-40.
1997: Derek Le Roith; VA Blakesley
The yin and the yang of the IGF system: immunological manifestations of GH resistance.
European journal of endocrinology / European Federation of Endocrine Societies 1997;136(1):33-4.
1996: VA Blakesley; A Scrimgeour; D Esposito; Derek Le Roith
Signaling via the insulin-like growth factor-I receptor: does it differ from insulin receptor signaling?
Cytokine & growth factor reviews 1996;7(2):153-9.