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Peter Leadlay

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Chompoonik Kanchanabanca; Zixin Deng; Frank Hahn; Hui Hong; Yajing Liu; Markiyan Samborskyy; Yuhui Sun; Weixin Tao; Peter F Leadlay
Unusual acetylation-elimination in the formation of tetronate antibiotics.
Laure Guenin-Macé; Hui Hong; Peter F Leadlay; Serge Mostowy; Guillaume Romet-Lemonne; Marie-Thérèse Ruf; Maria-Isabel Thoulouze; Romain Veyron-Churlet; Chiara Zurzolo; Philippe Bousso; Marie-France Carlier; Fabrice Chrétien; Anne Danckaert; Caroline Demangel
Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation.
Simone Herrmann; Caroline Jilg; Peter F Leadlay; Marta Luzhetska; Andreas Bechthold; Annette Erb; Lutz Petzke; Theresa Siegl; Elisabeth Welle; Andriy Luzhetskyy
Site-specific recombination strategies for engineering actinomycete genomes.

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2013: Chompoonik Kanchanabanca; Zixin Deng; Frank Hahn; Hui Hong; Yajing Liu; Markiyan Samborskyy; Yuhui Sun; Weixin Tao; Peter F Leadlay
Unusual acetylation-elimination in the formation of tetronate antibiotics.
Angewandte Chemie (International ed. in English) 2013;52(22):5785-8.
2013: Laure Guenin-Macé; Hui Hong; Peter F Leadlay; Serge Mostowy; Guillaume Romet-Lemonne; Marie-Thérèse Ruf; Maria-Isabel Thoulouze; Romain Veyron-Churlet; Chiara Zurzolo; Philippe Bousso; Marie-France Carlier; Fabrice Chrétien; Anne Danckaert; Caroline Demangel
Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation.
The Journal of clinical investigation 2013;123(4):1501-12.
2012: Simone Herrmann; Caroline Jilg; Peter F Leadlay; Marta Luzhetska; Andreas Bechthold; Annette Erb; Lutz Petzke; Theresa Siegl; Elisabeth Welle; Andriy Luzhetskyy
Site-specific recombination strategies for engineering actinomycete genomes.
Applied and environmental microbiology 2012;78(6):1804-12.
2011: Manuela Tosin; Luke Smith; Peter F Leadlay
Insights into lasalocid A ring formation by chemical chain termination in vivo.
Angewandte Chemie (International ed. in English) 2011;50(50):11930-3.
2011: Jeroen S Dickschat; Hannah C Dooley; Stephen Garner; Hui Hong; Peter F Leadlay; Susanna R Bidgood; Zixin Deng; Olivia Vergnolle; Yuhui Sun
An additional dehydratase-like activity is required for lankacidin antibiotic biosynthesis.
Chembiochem : a European journal of chemical biology 2011;12(16):2408-12.
2011: Olivia Vergnolle; Frank Hahn; Abel Baerga-Ortiz; Peter F Leadlay; Jennifer N Andexer
Stereoselectivity of isolated dehydratase domains of the borrelidin polyketide synthase: implications for cis double bond formation.
Chembiochem : a European journal of chemical biology 2011;12(7):1011-4.
2011: David H Kwan; Manuela Tosin; Nadin Schläger; Frank Schulz; Peter F Leadlay
Insights into the stereospecificity of ketoreduction in a modular polyketide synthase.
Organic & biomolecular chemistry 2011;9(7):2053-6.
2011: Manuela Tosin; Yuliya Demydchuk; James S Parascandolo; Covadonga Blasco Per; Finian Leeper; Peter F Leadlay
In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines.
Chemical communications (Cambridge, England) 2011;47(12):3460-2.
2011: Jennifer N Andexer; Steven G Kendrew; Mohammad Nur-e-Alam; Orestis Lazos; Teresa A Foster; Anna-Sophie Zimmermann; Tony D Warneck; Dipen Suthar; Nigel J Coates; Frank E Koehn; Jerauld S Skotnicki; Guy T Carter; Matthew A Gregory; Christine J Martin; Steven J Moss; Peter F Leadlay; Barrie Wilkinson
Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(12):4776-81.
2010: V Magdevska; R Gaber; D Goranovič; E Kuščer; S Boakes; M B Durán Alonso; R I Santamaría; Peter Raspor; Peter F Leadlay; Stefan Fujs; H Petković
Robust reporter system based on chalcone synthase rppA gene from Saccharopolyspora erythraea.
Journal of microbiological methods 2010;83(2):111-9.
2010: David H Kwan; Peter F Leadlay
Mutagenesis of a modular polyketide synthase enoylreductase domain reveals insights into catalysis and stereospecificity.
ACS chemical biology 2010;5(9):829-38.
2010: Marcio V B Dias; Fanglu Huang; Dimitri Y Chirgadze; Manuela Tosin; Dieter Spiteller; Emily F V Dry; Peter F Leadlay; Jonathan B Spencer; Tom L Blundell
Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK.
The Journal of biological chemistry 2010;285(29):22495-504.
2010: Manuela Tosin; Lorena Betancor; Elaine Stephens; W M Ariel Li; Jonathan B Spencer; Peter F Leadlay
Synthetic chain terminators off-load intermediates from a type I polyketide synthase.
Chembiochem : a European journal of chemical biology 2010;11(4):539-46.
2010: Orestis Lazos; Manuela Tosin; Adrian L Slusarczyk; Steven Boakes; Jesús Cortés; Philip J Sidebottom; Peter F Leadlay
Biosynthesis of the putative siderophore erythrochelin requires unprecedented crosstalk between separate nonribosomal peptide gene clusters.
Chemistry & biology 2010;17(2):160-73.
2010: Yuhui Sun; Frank Hahn; Yuliya Demydchuk; James Chettle; Manuela Tosin; Hiroyuki Osada; Peter F Leadlay
In vitro reconstruction of tetronate RK-682 biosynthesis.
Nature chemical biology 2010;6(2):99-101.
2009: Hui Hong; Peter F Leadlay; James Staunton
The changing patterns of covalent active site occupancy during catalysis on a modular polyketide synthase multienzyme revealed by ion-trap mass spectrometry.
The FEBS journal 2009;276(23):7057-69.
2008: David H Kwan; Yuhui Sun; Frank Schulz; Hui Hong; Bojana Popovic; Joalice C C Sim-Stark; Stephen F Haydock; Peter F Leadlay
Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases.
Chemistry & biology 2008;15(11):1231-40.
2008: Laurenz Kellenberger; Ian S Galloway; Guido Sauter; Günter Böhm; U Hanefeld; Jesús Cortés; James Staunton; Peter F Leadlay
A polylinker approach to reductive loop swaps in modular polyketide synthases.
Chembiochem : a European journal of chemical biology 2008;9(16):2740-9.
2008: Ursula Schell; Stephen F Haydock; Andrew L Kaja; Isabelle Carletti; Rachel E Lill; Eliot Read; Lesley S Sheehan; Lindsey Low; Maria-Jose Fernandez; Friederike Grolle; Hamish A I McArthur; Rose M Sheridan; Peter F Leadlay; Barrie Wilkinson; Sabine Gaisser
Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties.
Organic & biomolecular chemistry 2008;6(18):3315-27.
2008: Qingzhi Fan; Fanglu Huang; Peter F Leadlay; Jonathan B Spencer
The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase.
Organic & biomolecular chemistry 2008;6(18):3306-14.
2008: Hui Hong; Caroline Demangel; Sacha J Pidot; Peter F Leadlay; Timothy P Stinear
Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria.
Natural product reports 2008;25(3):447-54.
2008: Yuliya Demydchuk; Yuhui Sun; Hui Hong; James Staunton; Jonathan B Spencer; Peter F Leadlay
Analysis of the tetronomycin gene cluster: insights into the biosynthesis of a polyether tetronate antibiotic.
Chembiochem : a European journal of chemical biology 2008;9(7):1136-45.
2008: Andrew W Truman; Qingzhi Fan; Marlene Röttgen; Evi Stegmann; Peter F Leadlay; Jonathan B Spencer
The role of cep15 in the biosynthesis of chloroeremomycin: reactivation of an ancestral catalytic function.
Chemistry & biology 2008;15(5):476-84.
2008: Evelien M te Poele; Markiyan Samborskyy; Markiyan Oliynyk; Peter F Leadlay; Henk Bolhuis; Lubbert Dijkhuizen
Actinomycete integrative and conjugative pMEA-like elements of Amycolatopsis and Saccharopolyspora decoded.
Plasmid 2008;59(3):202-16.
2008: Lucky Tran; Manuela Tosin; Jonathan B Spencer; Peter F Leadlay; Kira J Weissman
Covalent linkage mediates communication between ACP and TE domains in modular polyketide synthases.
Chembiochem : a European journal of chemical biology 2008;9(6):905-15.
2008: Hrvoje Petković; Axel Sandmann; Iain R Challis; Hans-Jürgen Hecht; Barbara Silakowski; Lindsey Low; Nicola Beeston; Enej Kuscer; Jose Garcia-Bernardo; Peter F Leadlay; Steven G Kendrew; Barrie Wilkinson; Rolf Müller
Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase.
Organic & biomolecular chemistry 2008;6(3):500-6.
2008: Yuhui Sun; Hui Hong; Fraser Gillies; Jonathan B Spencer; Peter F Leadlay
Glyceryl-S-acyl carrier protein as an intermediate in the biosynthesis of tetronate antibiotics.
Chembiochem : a European journal of chemical biology 2008;9(1):150-6.
2008: Hui Hong; Emmanuelle Coutanceau; Marion Leclerc; Laxmee Caleechurn; Peter F Leadlay; Caroline Demangel
Mycolactone diffuses from Mycobacterium ulcerans-infected tissues and targets mononuclear cells in peripheral blood and lymphoid organs.
PLoS neglected tropical diseases 2008;2(10):e325.
2008: Sacha J Pidot; Hui Hong; Torsten Seemann; Jessica L Porter; Marcus J Yip; Artem Men; Matthew Johnson; Peter Wilson; John K Davies; Peter F Leadlay; Timothy P Stinear
Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones.
BMC genomics 2008;9():462.
2007: Hui Hong; Timothy P Stinear; Jessica Porter; Caroline Demangel; Peter F Leadlay
A novel mycolactone toxin obtained by biosynthetic engineering.
Chembiochem : a European journal of chemical biology 2007;8(17):2043-7.
2007: Barbara M Harvey; Tatiana Mironenko; Yuhui Sun; Hui Hong; Zixin Deng; Peter F Leadlay; Kira J Weissman; Stephen F Haydock
Insights into polyether biosynthesis from analysis of the nigericin biosynthetic gene cluster in Streptomyces sp. DSM4137.
Chemistry & biology 2007;14(6):703-14.
2007: Markiyan Oliynyk; Markiyan Samborskyy; John B Lester; Tatiana Mironenko; Nataliya Scott; Shilo Dickens; Stephen F Haydock; Peter F Leadlay
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.
Nature biotechnology 2007;25(4):447-53.
2006: Lesley S Sheehan; Rachel E Lill; Barrie Wilkinson; Rose M Sheridan; William A Vousden; Andrew L Kaja; Gary D Crouse; James Gifford; Paul R Graupner; Laura Karr; Paul Lewer; Thomas C Sparks; Peter F Leadlay; Clive Waldron; Christine J Martin
Engineering of the spinosyn PKS: directing starter unit incorporation.
Journal of natural products 2006;69(12):1702-10.
2006: Yuhui Sun; Hui Hong; Markiyan Samborskyy; Markiyan Samboskyy; Tatiana Mironenko; Peter F Leadlay; Stephen F Haydock
Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.
Microbiology (Reading, England) 2006;152(Pt 12):3507-15.
2006: Barrie Wilkinson; Matthew A Gregory; Steven J Moss; Isabelle Carletti; Rose M Sheridan; Andrew Kaja; Michael Ward; Carlos Olano; Carmen Mendez; José A Salas; Peter F Leadlay; Rob vanGinckel; Ming-Qiang Zhang
Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
Bioorganic & medicinal chemistry letters 2006;16(22):5814-7.
2006: Matthew A Gregory; Hui Hong; Rachel E Lill; Sabine Gaisser; Hrvoje Petkovic; Lindsey Low; Lesley S Sheehan; Isabelle Carletti; Sarah J Ready; Michael J Ward; Andrew L Kaja; Alison J Weston; Iain R Challis; Peter F Leadlay; Christine J Martin; Barrie Wilkinson; Rose M Sheridan
Rapamycin biosynthesis: Elucidation of gene product function.
Organic & biomolecular chemistry 2006;4(19):3565-8.
2006: Barbara M Harvey; Hui Hong; Michelle A Jones; Zoë A Hughes-Thomas; Rebecca M Goss; Michelle L Heathcote; Victor Martin Bolanos-Garcia; Wolfgang Kroutil; James Staunton; Peter F Leadlay; Jonathan B Spencer
Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin.
Chembiochem : a European journal of chemical biology 2006;7(9):1435-42.
2006: Steven J Moss; Isabelle Carletti; Carlos Olano; Rose M Sheridan; Michael Ward; Vidya Math; Mohammad Nur-e-Alam; Alfredo F Braña; Ming Qiang Zhang; Peter F Leadlay; Carmen Méndez; José A Salas; Barrie Wilkinson
Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues.
Chemical communications (Cambridge, England) 2006;(22):2341-3.
2006: Fanglu Huang; Stephen F Haydock; Dieter Spiteller; Tatiana Mironenko; Tsung-Lin Li; David O'Hagan; Peter F Leadlay; Jonathan B Spencer
The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A.
Chemistry & biology 2006;13(5):475-84.
2006: Andrew R Gallimore; Christian B W Stark; Apoorva Bhatt; Barbara M Harvey; Yuliya Demydchuk; Victor Martin Bolanos-Garcia; Daniel J Fowler; James Staunton; Peter F Leadlay; Jonathan B Spencer
Evidence for the role of the monB genes in polyether ring formation during monensin biosynthesis.
Chemistry & biology 2006;13(4):453-60.
2006: Helen M O'Hare; Abel Baerga-Ortiz; Bojana Popovic; Jonathan B Spencer; Peter F Leadlay
High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase.
Chemistry & biology 2006;13(3):287-96.
2006: Abel Baerga-Ortiz; Bojana Popovic; Alexandros P Siskos; Helen M O'Hare; Dieter Spiteller; Mark G Williams; Nuria Campillo; Jonathan B Spencer; Peter F Leadlay
Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase.
Chemistry & biology 2006;13(3):277-85.
2005: Kira J Weissman; Peter F Leadlay
Combinatorial biosynthesis of reduced polyketides.
Nature reviews. Microbiology 2005;3(12):925-36.
2005: Apoorva Bhatt; Christian B W Stark; Barbara M Harvey; Andrew R Gallimore; Yuliya Demydchuk; Jonathan B Spencer; James Staunton; Peter F Leadlay
Accumulation of an E,E,E-triene by the monensin-producing polyketide synthase when oxidative cyclization is blocked.
Angewandte Chemie (International ed. in English) 2005;44(43):7075-8.
2005: Alexandros P Siskos; Abel Baerga-Ortiz; Shilpa Bali; Viktor Stein; Hassan Mamdani; Dieter Spiteller; Bojana Popovic; Jonathan B Spencer; James Staunton; Kira J Weissman; Peter F Leadlay
Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases.
Chemistry & biology 2005;12(10):1145-53.
2005: Stephen F Haydock; Antony appleyard; Tatiana Mironenko; John Lester; Natasha Scott; Peter F Leadlay
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.
Microbiology (Reading, England) 2005;151(Pt 10):3161-9.
2005: Hui Hong; Timothy P Stinear; Paul Skelton; Jonathan B Spencer; Peter F Leadlay
Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry.
Chemical communications (Cambridge, England) 2005;(34):4306-8.
2005: Matthew A Gregory; Hrvoje Petkovic; Rachel E Lill; Steven J Moss; Barrie Wilkinson; Sabine Gaisser; Peter F Leadlay; Rose M Sheridan
Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis.
Angewandte Chemie (International ed. in English) 2005;44(30):4757-60.
2005: Hui Hong; Antony appleyard; Alexandros P Siskos; Jose Garcia-Bernardo; James Staunton; Peter F Leadlay
Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion-trap mass spectrometry.
The FEBS journal 2005;272(10):2373-87.
2005: Hui Hong; Jonathan B Spencer; Jessica L Porter; Peter F Leadlay; Timothy P Stinear
A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase.
Chembiochem : a European journal of chemical biology 2005;6(4):643-8.
2005: Timothy P Stinear; Hui Hong; Wafa Frigui; Melinda J Pryor; Roland Brosch; Thierry Garnier; Peter F Leadlay; Stewart T Cole
Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans.
Journal of bacteriology 2005;187(5):1668-76.
2004: Stephen F Haydock; Tatiana Mironenko; Haroun I Ghoorahoo; Peter F Leadlay
The putative elaiophylin biosynthetic gene cluster in Streptomyces sp. DSM4137 is adjacent to genes encoding adenosylcobalamin-dependent methylmalonyl CoA mutase and to genes for synthesis of cobalamin.
Journal of biotechnology 2004;113(1-3):55-68.
2004: Jose Garcia-Bernardo; Longkuan Xiang; Hui Hong; Bradley S Moore; Peter F Leadlay
Engineered biosynthesis of phenyl-substituted polyketides.
Chembiochem : a European journal of chemical biology 2004;5(8):1129-31.
2004: Carlos Olano; Steven J Moss; Alfredo F Braña; Rose M Sheridan; Vidya Math; Alison J Weston; Carmen Méndez; Peter F Leadlay; Barrie Wilkinson; José A Salas
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation.
Molecular microbiology 2004;52(6):1745-56.
2004: Matthew A Gregory; Sabine Gaisser; Rachel E Lill; Hui Hong; Rose M Sheridan; Barrie Wilkinson; Hrvoje Petkovic; Alison J Weston; Isabelle Carletti; Huai-Lo Lee; James Staunton; Peter F Leadlay
Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus.
Angewandte Chemie (International ed. in English) 2004;43(19):2551-3.
2004: Philip A S Lowden; Günter A Böhm; Su Metcalfe; James Staunton; Peter F Leadlay
New rapamycin derivatives by precursor-directed biosynthesis.
Chembiochem : a European journal of chemical biology 2004;5(4):535-8.
2004: Timothy P Stinear; Armand Mve-Obiang; Pamela L C Small; Wafa Frigui; Melinda J Pryor; Roland Brosch; Grant A Jenkin; Paul Johnson; John K Davies; Richard E Lee; Sarojini Adusumilli; Thierry Garnier; Stephen F Haydock; Peter F Leadlay; Stewart T Cole
Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(5):1345-9.
2004: Kira J Weissman; Hui Hong; Markiyan Oliynyk; Alexandros P Siskos; Peter F Leadlay
Identification of a phosphopantetheinyl transferase for erythromycin biosynthesis in Saccharopolyspora erythraea.
Chembiochem : a European journal of chemical biology 2004;5(1):116-25.
2004: Steven Boakes; Markiyan Oliynyk; Jesús Cortés; Ines Böhm; Brian A M Rudd; W Peter Revill; James Staunton; Peter F Leadlay
A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea.
Journal of molecular microbiology and biotechnology 2004;8(2):73-80.
2004: Tsung-Lin Li; Fanglu Huang; Stephen F Haydock; Tatiana Mironenko; Peter F Leadlay; Jonathan B Spencer
Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase.
Chemistry & biology 2004;11(1):107-19.
2004: Carlos Olano; Barrie Wilkinson; César Sánchez; Steven J Moss; Rose Sheridan; Vidya Math; Alison J Weston; Alfredo F Braña; Christine J Martin; Markiyan Oliynyk; Carmen Méndez; Peter F Leadlay; José A Salas
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions.
Chemistry & biology 2004;11(1):87-97.
2003: Christine J Martin; Máire C Timoney; Rose M Sheridan; Steven G Kendrew; Barrie Wilkinson; James Staunton; Peter F Leadlay
Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthase.
Organic & biomolecular chemistry 2003;1(23):4144-7.
2003: Hui Hong; Paul J Gates; James Staunton; Timothy P Stinear; Stewart T Cole; Peter F Leadlay; Jonathan B Spencer
Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans.
Chemical communications (Cambridge, England) 2003;(22):2822-3.
2003: Carlos Olano; Barrie Wilkinson; Steven J Moss; Alfredo F Braña; Carmen Méndez; Peter F Leadlay; José A Salas
Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase.
Chemical communications (Cambridge, England) 2003;(22):2780-2.
2003: Corinne M Squire; Rebecca J M Goss; Hui Hong; Peter F Leadlay; James Staunton
Catalytically active tetramodular 6-deoxyerythonolide B synthase fusion proteins.
Chembiochem : a European journal of chemical biology 2003;4(11):1225-8.
2003: Zoë A Hughes-Thomas; Christian B W Stark; Ines Böhm; James Staunton; Peter F Leadlay
Intermediates released from a polyether-producing polyketide synthase provide insight into the mechanism of oxidative cyclization.
Angewandte Chemie (International ed. in English) 2003;42(37):4475-8.
2003: Markiyan Oliynyk; Christian B W Stark; Apoorva Bhatt; Michelle A Jones; Zoë A Hughes-Thomas; Christopher Wilkinson; Zoryana Oliynyk; Yuliya Demydchuk; James Staunton; Peter F Leadlay
Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization.
Molecular microbiology 2003;49(5):1179-90.
2003: Sabine Gaisser; Laurenz Kellenberger; Andrew L Kaja; Alison J Weston; Rachel E Lill; Gabriele Wirtz; Steven G Kendrew; Lindsey Low; Rose M Sheridan; Barrie Wilkinson; Ian S Galloway; Kim J Stutzman-Engwall; Hamish McArthur; James Staunton; Peter F Leadlay
Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272.
Organic & biomolecular chemistry 2003;1(16):2840-7.
2003: R William Broadhurst; Daniel Nietlispach; Michael Wheatcroft; Peter F Leadlay; Kira J Weissman
The structure of docking domains in modular polyketide synthases.
Chemistry & biology 2003;10(8):723-31.
2003: Francesca Del Vecchio; Hrvoje Petkovic; Steven G Kendrew; Lindsey Low; Barrie Wilkinson; Rachel E Lill; Jesús Cortés; Brian A M Rudd; James Staunton; Peter F Leadlay
Active-site residue, domain and module swaps in modular polyketide synthases.
Journal of industrial microbiology & biotechnology 2003;30(8):489-94.
2003: Hrvoje Petkovic; Rachel E Lill; Rose M Sheridan; Barrie Wilkinson; Ellen McCormick; Hamish McArthur; James Staunton; Peter F Leadlay; Steven G Kendrew
A novel erythromycin, 6-desmethyl erythromycin D, made by substituting an acyltransferase domain of the erythromycin polyketide synthase.
The Journal of antibiotics 2003;56(6):543-51.
2003: Peter F Leadlay; Abel Baerga-Ortiz
Mammalian fatty acid synthase: closure on a textbook mechanism?
Chemistry & biology 2003;10(2):101-3.
2002: Iain Thomas; Christine J Martin; Christopher J Wilkinson; James Staunton; Peter F Leadlay
Skipping in a hybrid polyketide synthase. Evidence for ACP-to-ACP chain transfer.
Chemistry & biology 2002;9(7):781-7.
2002: Christopher J Wilkinson; Zoë A Hughes-Thomas; Christine J Martin; Ines Böhm; Tatiana Mironenko; Matthew Deacon; Michael Wheatcroft; Gabriele Wirtz; James Staunton; Peter F Leadlay
Increasing the efficiency of heterologous promoters in actinomycetes.
Journal of molecular microbiology and biotechnology 2002;4(4):417-26.
2002: Sabine Gaisser; Rachel E Lill; James Staunton; Carmen Méndez; José Salas; Peter F Leadlay
Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea.
Molecular microbiology 2002;44(3):771-81.
2002: Sabine Gaisser; Christine J Martin; Barrie Wilkinson; Rose M Sheridan; Rachel E Lill; Alison J Weston; Sarah J Ready; Clive Waldron; Gary D Crouse; Peter F Leadlay; James Staunton
Engineered biosynthesis of novel spinosyns bearing altered deoxyhexose substituents.
Chemical communications (Cambridge, England) 2002;(6):618-9.
2002: Paul F Long; Christopher J Wilkinson; Christian P Bisang; Jesús Cortés; Nicholas Dunster; Markiyan Oliynyk; Ellen McCormick; Hamish McArthur; Carmen Mendez; José A Salas; James Staunton; Peter F Leadlay
Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase.
Molecular microbiology 2002;43(5):1215-25.
2002: Lars H Østergaard; Laurenz Kellenberger; Jesús Cortés; Marc P Roddis; Matthew Deacon; James Staunton; Peter F Leadlay
Stereochemistry of catalysis by the ketoreductase activity in the first extension module of the erythromycin polyketide synthase.
Biochemistry 2002;41(8):2719-26.
2002: Gabriele Weitnauer; Sabine Gaisser; Laurenz Kellenberger; Peter F Leadlay; Andreas Bechthold
Analysis of a C-methyltransferase gene (aviG1) involved in avilamycin biosynthesis in Streptomyces viridochromogenes Tü57 and complementation of a Saccharopolyspora erythraea eryBIII mutant by aviG1.
Microbiology (Reading, England) 2002;148(Pt 2):373-9.
2001: Peter F Leadlay; James Staunton; Markiyan Oliynyk; Christian P Bisang; Jesús Cortés; EJ Frost; Zoë A Hughes-Thomas; Michelle A Jones; Steven G Kendrew; J B Lester; Paul F Long; Hamish McArthur; Ellen McCormick; Z Oliynyk; Christian B W Stark; Christopher J Wilkinson
Engineering of complex polyketide biosynthesis--insights from sequencing of the monensin biosynthetic gene cluster.
Journal of industrial microbiology & biotechnology 2001;27(6):360-7.
2001: Christopher J Wilkinson; EJ Frost; James Staunton; Peter F Leadlay
Chain initiation on the soraphen-producing modular polyketide synthase from Sorangium cellulosum.
Chemistry & biology 2001;8(12):1197-208.
2001: Sabine Gaisser; Rachel E Lill; Gabriele Wirtz; F Grolle; James Staunton; Peter F Leadlay
New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster.
Molecular microbiology 2001;41(5):1223-31.
2001: CJ Rowe; Ines Böhm; Iain Thomas; Barrie Wilkinson; Brian A M Rudd; Graham Foster; Andrew P Blackaby; Philip J Sidebottom; Y Roddis; AD Buss; James Staunton; Peter F Leadlay
Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase.
Chemistry & biology 2001;8(5):475-85.
2001: IE Holzbaur; A Ranganathan; Iain Thomas; D J Kearney; J A Reather; Brian A M Rudd; James Staunton; Peter F Leadlay
Molecular basis of Celmer's rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates.
Chemistry & biology 2001;8(4):329-40.
2001: M L Heathcote; James Staunton; Peter F Leadlay
Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units.
Chemistry & biology 2001;8(2):207-20.
2000: NH Thomä; Philip R Evans; Peter F Leadlay
Protection of radical intermediates at the active site of adenosylcobalamin-dependent methylmalonyl-CoA mutase.
Biochemistry 2000;39(31):9213-21.
2000: Sabine Gaisser; J Reather; Gabriele Wirtz; Laurenz Kellenberger; James Staunton; Peter F Leadlay
A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea.
Molecular microbiology 2000;36(2):391-401.
2000: Barrie Wilkinson; Graham Foster; Brian A M Rudd; NL Taylor; Andrew P Blackaby; Philip J Sidebottom; D J Cooper; Michael J Dawson; AD Buss; Sabine Gaisser; Ines Böhm; CJ Rowe; Jesús Cortés; Peter F Leadlay; James Staunton
Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase.
Chemistry & biology 2000;7(2):111-7.
2000: Mark Bycroft; Kira J Weissman; James Staunton; Peter F Leadlay
Efficient purification and kinetic characterization of a bimodular derivative of the erythromycin polyketide synthase.
European journal of biochemistry / FEBS 2000;267(2):520-6.
1999: A Ranganathan; Máire C Timoney; Mark Bycroft; Jesús Cortés; Iain Thomas; Barrie Wilkinson; Laurenz Kellenberger; U Hanefeld; I S Galloway; James Staunton; Peter F Leadlay
Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues.
Chemistry & biology 1999;6(10):731-41.
1999: Christian P Bisang; Paul F Long; Jesús Cortés; James Westcott; John Crosby; Anne-Lise Matharu; Russell Cox; Thomas J Simpson; James Staunton; Peter F Leadlay
A chain initiation factor common to both modular and aromatic polyketide synthases.
Nature 1999;401(6752):502-5.
1999: IE Holzbaur; R C Harris; Mark Bycroft; J Cortes; Christian P Bisang; James Staunton; Brian A M Rudd; Peter F Leadlay
Molecular basis of Celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase.
Chemistry & biology 1999;6(4):189-95.
1999: G C Kearney; Paul J Gates; Peter F Leadlay; James Staunton; R Jones
Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry II.
Rapid communications in mass spectrometry : RCM 1999;13(16):1650-6.
1999: Paul J Gates; G C Kearney; R Jones; Peter F Leadlay; James Staunton
Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 1999;13(4):242-6.
1998: Kira J Weissman; Mark Bycroft; A L Cutter; U Hanefeld; EJ Frost; Máire C Timoney; R Harris; S Handa; Marc P Roddis; James Staunton; Peter F Leadlay
Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase.
Chemistry & biology 1998;5(12):743-54.
1998: MS Pacey; John P Dirlam; R W Geldart; Peter F Leadlay; Hamish McArthur; Ellen McCormick; RA Monday; TN O'Connell; James Staunton; T J Winchester
Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity.
The Journal of antibiotics 1998;51(11):1029-34.
1998: NH Thomä; T W Meier; Philip R Evans; Peter F Leadlay
Stabilization of radical intermediates by an active-site tyrosine residue in methylmalonyl-CoA mutase.
Biochemistry 1998;37(41):14386-93.
1998: R T Celis; Peter F Leadlay; I Roy; A Hansen
Phosphorylation of the periplasmic binding protein in two transport systems for arginine incorporation in Escherichia coli K-12 is unrelated to the function of the transport system.
Journal of bacteriology 1998;180(18):4828-33.
1998: CJ Rowe; Jesús Cortés; Sabine Gaisser; James Staunton; Peter F Leadlay
Construction of new vectors for high-level expression in actinomycetes.
Gene 1998;216(1):215-23.
1998: Kira J Weissman; Mark Bycroft; James Staunton; Peter F Leadlay
Origin of starter units for erythromycin biosynthesis.
Biochemistry 1998;37(31):11012-7.
1998: NH Thomä; Peter F Leadlay
Mechanistic and structural studies on methylmalonyl-CoA mutase.
Biochemical Society transactions 1998;26(3):293-8.
1998: Ines Böhm; IE Holzbaur; U Hanefeld; Jesús Cortés; James Staunton; Peter F Leadlay
Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension.
Chemistry & biology 1998;5(8):407-12.
1998: Sabine Gaisser; G A Böhm; M Doumith; MC Raynal; N Dhillon; Jesús Cortés; Peter F Leadlay
Analysis of eryBI, eryBIII and eryBVII from the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea.
Molecular & general genetics : MGG 1998;258(1-2):78-88.
1998: K Salah-Bey; M Doumith; JM Michel; Stephen F Haydock; Jesús Cortés; Peter F Leadlay; MC Raynal
Targeted gene inactivation for the elucidation of deoxysugar biosynthesis in the erythromycin producer Saccharopolyspora erythraea.
Molecular & general genetics : MGG 1998;257(5):542-53.
1998: L E Khaw; G A Böhm; S Metcalfe; James Staunton; Peter F Leadlay
Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase.
Journal of bacteriology 1998;180(4):809-14.
1998: A F Marsden; Barrie Wilkinson; Jesús Cortés; N J Dunster; James Staunton; Peter F Leadlay
Engineering broader specificity into an antibiotic-producing polyketide synthase.
Science (New York, N.Y.) 1998;279(5348):199-202.
1998: Sabine Gaisser; Peter F Leadlay
Sugaring the pill by design.
Nature biotechnology 1998;16(1):19-20.
1997: Kira J Weissman; Máire C Timoney; Mark Bycroft; P Grice; U Hanefeld; James Staunton; Peter F Leadlay
The molecular basis of Celmer's rules: the stereochemistry of the condensation step in chain extension on the erythromycin polyketide synthase.
Biochemistry 1997;36(45):13849-55.
1997: Sabine Gaisser; G A Böhm; Jesús Cortés; Peter F Leadlay
Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea.
Molecular & general genetics : MGG 1997;256(3):239-51.
1997: Peter F Leadlay
Combinatorial approaches to polyketide biosynthesis.
Current opinion in chemical biology 1997;1(2):162-8.
1997: A König; T Schwecke; I Molnar; G A Böhm; Philip A S Lowden; James Staunton; Peter F Leadlay
The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin--nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus.
European journal of biochemistry / FEBS 1997;247(2):526-34.
1996: M Oliynyk; M J Brown; Jesús Cortés; James Staunton; Peter F Leadlay
A hybrid modular polyketide synthase obtained by domain swapping.
Chemistry & biology 1996;3(10):833-9.
1996: T W Meier; N H Thomä; Peter F Leadlay
Tritium isotope effects in adenosylcobalamin-dependent methylmalonyl-CoA mutase.
Biochemistry 1996;35(36):11791-6.
1996: N H Thomä; Peter F Leadlay
Homology modeling of human methylmalonyl-CoA mutase: a structural basis for point mutations causing methylmalonic aciduria.
Protein science : a publication of the Protein Society 1996;5(9):1922-7.
1996: F Mancia; NH Keep; A Nakagawa; Peter F Leadlay; S McSweeney; B Rasmussen; P Bösecke; O Diat; Philip R Evans
How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 A resolution.
Structure (London, England : 1993) 1996;4(3):339-50.
1996: Jesus Aparicio; I Molnár; T Schwecke; A König; S F Haydock; L E Khaw; James Staunton; Peter F Leadlay
Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase.
Gene 1996;169(1):9-16.
1996: I Molnár; Jesus Aparicio; S F Haydock; L E Khaw; T Schwecke; A König; James Staunton; Peter F Leadlay
Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.
Gene 1996;169(1):1-7.
1996: James Staunton; P Caffrey; Jesus Aparicio; G A Roberts; S S Bethell; Peter F Leadlay
Evidence for a double-helical structure for modular polyketide synthases.
Nature structural biology 1996;3(2):188-92.
1995: S F Haydock; Jesus Aparicio; I Molnár; T Schwecke; L E Khaw; A König; A F Marsden; I S Galloway; James Staunton; Peter F Leadlay
Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases.
FEBS letters 1995;374(2):246-8.
1995: K E Wiesmann; Jesús Cortés; M J Brown; A L Cutter; James Staunton; Peter F Leadlay
Polyketide synthesis in vitro on a modular polyketide synthase.
Chemistry & biology 1995;2(9):583-9.
1995: J Cortes; K E Wiesmann; G A Roberts; M J Brown; James Staunton; Peter F Leadlay
Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage.
Science (New York, N.Y.) 1995;268(5216):1487-9.
1994: Jesus Aparicio; P Caffrey; A F Marsden; James Staunton; Peter F Leadlay
Limited proteolysis and active-site studies of the first multienzyme component of the erythromycin-producing polyketide synthase.
The Journal of biological chemistry 1994;269(11):8524-8.
1994: K J Linton; H N Cooper; Iain S Hunter; Peter F Leadlay
An ABC-transporter from Streptomyces longisporoflavus confers resistance to the polyether-ionophore antibiotic tetronasin.
Molecular microbiology 1994;11(4):777-85.
1994: A F Marsden; P Caffrey; Jesus Aparicio; M S Loughran; James Staunton; Peter F Leadlay
Stereospecific acyl transfers on the erythromycin-producing polyketide synthase.
Science (New York, N.Y.) 1994;263(5145):378-80.
1993: NH Keep; G A Smith; M C Evans; G P Diakun; Peter F Leadlay
The synthetic substrate succinyl(carbadethia)-CoA generates cob(II)alamin on adenosylcobalamin-dependent methylmalonyl-CoA mutase.
The Biochemical journal 1993;295 ( Pt 2)():387-92.
1993: S A Morris; W P Revill; James Staunton; Peter F Leadlay
Purification and separation of holo- and apo-forms of Saccharopolyspora erythraea acyl-carrier protein released from recombinant Escherichia coli by freezing and thawing.
The Biochemical journal 1993;294 ( Pt 2)():521-7.
1993: G A Roberts; James Staunton; Peter F Leadlay
Heterologous expression in Escherichia coli of an intact multienzyme component of the erythromycin-producing polyketide synthase.
European journal of biochemistry / FEBS 1993;214(1):305-11.
1993: G A Roberts; James Staunton; Peter F Leadlay
6-Deoxyerythronolide B synthase 3 from Saccharopolyspora erythraea: over-expression in Escherichia coli, purification and characterisation.
Biochemical Society transactions 1993;21(1):32S.
1993: H N Cooper; J Cortes; D J Bevitt; Peter F Leadlay; James Staunton
Analysis of a gene cluster from S. longisporoflavus potentially involved in tetronasin biosynthesis.
Biochemical Society transactions 1993;21(1):31S.
1993: D J Bevitt; James Staunton; Peter F Leadlay
Mutagenesis of the dehydratase active site in the erythromycin-producing polyketide synthase.
Biochemical Society transactions 1993;21(1):30S.
1993: Peter F Leadlay; James Staunton; Jesus Aparicio; D J Bevitt; P Caffrey; J Cortes; A Marsden; G A Roberts
The erythromycin-producing polyketide synthase.
Biochemical Society transactions 1993;21(1):218-22.
1992: I Roy; Peter F Leadlay
Physical map location of the new Escherichia coli gene sbm.
Journal of bacteriology 1992;174(17):5763-4.
1992: P Caffrey; D J Bevitt; James Staunton; Peter F Leadlay
Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea.
FEBS letters 1992;304(2-3):225-8.
1992: D J Bevitt; J Cortes; S F Haydock; Peter F Leadlay
6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme.
European journal of biochemistry / FEBS 1992;204(1):39-49.
1991: S F Haydock; J A Dowson; N Dhillon; G A Roberts; J Cortes; Peter F Leadlay
Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases.
Molecular & general genetics : MGG 1991;230(1-2):120-8.
1991: W P Revill; Peter F Leadlay
Cloning, characterization, and high-level expression in Escherichia coli of the Saccharopolyspora erythraea gene encoding an acyl carrier protein potentially involved in fatty acid biosynthesis.
Journal of bacteriology 1991;173(14):4379-85.
1991: P Caffrey; B Green; Len C Packman; B J Rawlings; James Staunton; Peter F Leadlay
An acyl-carrier-protein-thioesterase domain from the 6-deoxyerythronolide B synthase of Saccharopolyspora erythraea. High-level production, purification and characterisation in Escherichia coli.
European journal of biochemistry / FEBS 1991;195(3):823-30.
1990: J Cortes; S F Haydock; G A Roberts; D J Bevitt; Peter F Leadlay
An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.
Nature 1990;348(6297):176-8.
1990: N McKie; NH Keep; M L Patchett; Peter F Leadlay
Adenosylcobalamin-dependent methylmalonyl-CoA mutase from Propionibacterium shermanii. Active holoenzyme produced from Escherichia coli.
The Biochemical journal 1990;269(2):293-8.
1990: K P Williams; Peter F Leadlay; P N Lowe
Inhibition of pyruvate:ferredoxin oxidoreductase from Trichomonas vaginalis by pyruvate and its analogues. Comparison with the pyruvate decarboxylase component of the pyruvate dehydrogenase complex.
The Biochemical journal 1990;268(1):69-75.
1990: N Dhillon; Peter F Leadlay
A repeated decapeptide motif in the C-terminal domain of the ribosomal RNA methyltransferase from the erythromycin producer Saccharopolyspora erythraea.
FEBS letters 1990;262(2):189-93.
1989: D G Swan; J Cortes; R S Hale; Peter F Leadlay
Cloning, characterization, and heterologous expression of the Saccharopolyspora erythraea (Streptomyces erythraeus) gene encoding an EF-hand calcium-binding protein.
Journal of bacteriology 1989;171(10):5614-9.
1989: N Dhillon; R S Hale; J Cortes; Peter F Leadlay
Molecular characterization of a gene from Saccharopolyspora erythraea (Streptomyces erythraeus) which is involved in erythromycin biosynthesis.
Molecular microbiology 1989;3(10):1405-14.
1989: E Neil Marsh; S E Harding; Peter F Leadlay
Subunit interactions in Propionibacterium shermanii methylmalonyl-CoA mutase studied by analytical ultracentrifugation.
The Biochemical journal 1989;260(2):353-8.
1989: E Neil Marsh; N McKie; N K Davis; Peter F Leadlay
Cloning and structural characterization of the genes coding for adenosylcobalamin-dependent methylmalonyl-CoA mutase from Propionibacterium shermanii.
The Biochemical journal 1989;260(2):345-52.
1989: E Neil Marsh; Peter F Leadlay
Methylmalonyl-CoA mutase from Propionibacterium shermanii. Evidence for the presence of two masked cysteine residues.
The Biochemical journal 1989;260(2):339-43.
1988: N Marsh; Peter F Leadlay; P R Evans
Crystallization and preliminary diffraction data for adenosylcobalamin-dependent methylmalonyl-CoA mutase from Propionibacterium shermanii.
Journal of molecular biology 1988;200(2):421-2.
1987: R S Hale; K N Jordan; Peter F Leadlay
A small, discrete acyl carrier protein is involved in de novo fatty acid biosynthesis in Streptomyces erythraeus.
FEBS letters 1987;224(1):133-6.
1987: D G Swan; R S Hale; N Dhillon; Peter F Leadlay
A bacterial calcium-binding protein homologous to calmodulin.
Nature 1987;329(6134):84-5.
1987: K Williams; P N Lowe; Peter F Leadlay
Purification and characterization of pyruvate: ferredoxin oxidoreductase from the anaerobic protozoon Trichomonas vaginalis.
The Biochemical journal 1987;246(2):529-36.
1986: F Francalanci; N K Davis; J Q Fuller; D Murfitt; Peter F Leadlay
The subunit structure of methylmalonyl-CoA mutase from Propionibacterium shermanii.
The Biochemical journal 1986;236(2):489-94.
1985: R S Hale; Peter F Leadlay
Oligonucleotide probes for bacterial acylcarrier protein genes.
Biochimie 1985;67(7-8):835-9.
1983: J Q Fuller; Peter F Leadlay
Proton transfer in methylmalonyl-CoA epimerase from Propionibacterium shermanii. The reaction of (2R)-methylmalonyl-CoA in tritiated water.
The Biochemical journal 1983;213(3):643-50.
1983: Peter F Leadlay; J Q Fuller
Proton transfer in methylmalonyl-CoA epimerase from Propionibacterium shermanii. Studies with specifically tritiated (2R)-methylmalonyl-CoA as substrate.
The Biochemical journal 1983;213(3):635-42.