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Andrew Leask

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TOP 3
Fen Guo; James Hutchenreuther; David E Carter; Andrew Leask
TAK1 Is Required for Dermal Wound Healing and Homeostasis.
Shangxi Liu; Andrew Leask
Integrin β1 is required for dermal homeostasis.
Andrew Leask
Sonic advance: CCN1 regulates sonic hedgehog in pancreatic cancer.

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All Publications

2013: Fen Guo; James Hutchenreuther; David E Carter; Andrew Leask
TAK1 Is Required for Dermal Wound Healing and Homeostasis.
The Journal of investigative dermatology 2013;133(6):1646-54.
2013: Shangxi Liu; Andrew Leask
Integrin β1 is required for dermal homeostasis.
The Journal of investigative dermatology 2013;133(4):899-906.
2013: Andrew Leask
Sonic advance: CCN1 regulates sonic hedgehog in pancreatic cancer.
Journal of cell communication and signaling 2013;7(1):61-2.
2013: Matthew M Riopel; Andrew Leask; Jinming Li; Shangxi Liu; Rennian Wang
β1 integrin-extracellular matrix interactions are essential for maintaining exocrine pancreas architecture and function.
Laboratory investigation; a journal of technical methods and pathology 2013;93(1):31-40.
2012: Xu Shi-wen; Katherine Thompson; Murray Baron; Christopher P Denton; Korsa Khan; Andrew Leask; Shangxi Liu; Hannah Murphy-Marshman; David J Abraham
Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts.
Rheumatology (Oxford, England) 2012;51(12):2146-54.
2012: Shangxi Liu; Andrew Leask
Integrin β1 is required for maintenance of vascular tone in postnatal mice.
Journal of cell communication and signaling 2012;6(3):175-80.
2012: Andrew Leask
Emerging targets for the treatment of scleroderma.
Expert opinion on emerging drugs 2012;17(2):173-9.
2012: Andrew Leask
CCN3: a novel anti-fibrotic treatment in end-stage renal disease?
Journal of cell communication and signaling 2012;6(2):115-6.
2012: Andrew Leask
Egr-ly awaiting a "personalized medicine" approach to treat scleroderma.
Journal of cell communication and signaling 2012;6(2):111-3.
2012: David Lagares; Santiago Lamas; Andrew Leask; Shangxi Liu; David Abraham; Oscar Busnadiego; Patricia Carreira; David E Carter; Benjamin A Fontaine; Rosa Ana García-Fernández; Mohit Kapoor; Barry S Shea; Xu Shi-wen; Andrew M Tager; Fernando Rodríguez-Pascual
Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation.
Arthritis and rheumatism 2012;64(5):1653-64.
2012: Andrew Leask
MEK/ERK inhibitors: proof-of-concept studies in lung fibrosis.
Journal of cell communication and signaling 2012;6(1):59-60.
2012: Andrew Leask
Sp1king out cancer (....and fibrosis?).
Journal of cell communication and signaling 2012;6(1):61-2.
2012: Andrew Leask
Getting out of a sticky situation: targeting the myofibroblast in scleroderma.
The open rheumatology journal 2012;6():163-9.
2012: Wei Sha; Jennifer South; Katherine Thompson; Murray Baron; Andrew Leask
Loss of PPARγ expression by fibroblasts enhances dermal wound closure.
Fibrogenesis & tissue repair 2012;5():5.
2012: Christopher G Elliott; Jianjun Guan; Xiaolei Guo; Simon J Conway; Mark Eastwood; Andrew Leask; Jian Wang; Shi-wen Xu; Douglas W Hamilton
Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair.
Journal of cell science 2012;125(Pt 1):121-32.
2011: Sunil K Parapuram; Xu Shi-wen; Ian D Welch; David J Abraham; Murray Baron; Christopher P Denton; Christopher Elliott; Helen Jones; Andrew Leask
Loss of PTEN expression by dermal fibroblasts causes skin fibrosis.
The Journal of investigative dermatology 2011;131(10):1996-2003.
2011: Wei Sha; Andrew Leask
CCN2 expression and localization in melanoma cells.
Journal of cell communication and signaling 2011;5(3):219-26.
2011: Shangxi Liu; Andrew Leask
CCN2 is not required for skin development.
Journal of cell communication and signaling 2011;5(3):179-82.
2011: Andrew Leask
CCN2/decorin interactions: a novel approach to combating fibrosis?
Journal of cell communication and signaling 2011;5(3):249-50.
2011: Andrew Leask
Possible strategies for anti-fibrotic drug intervention in scleroderma.
Journal of cell communication and signaling 2011;5(2):125-9.
2011: Andrew Leask
CCN2: a bona fide target for anti-fibrotic drug intervention.
Journal of cell communication and signaling 2011;5(2):131-3.
2011: Andrew Leask
CCN1: a novel target for pancreatic cancer.
Journal of cell communication and signaling 2011;5(2):123-4.
2011: Andrew Leask
The role of endothelin-1 signaling in the fibrosis observed in systemic sclerosis.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;63(6):502-3.
2011: M Riopel; M Krishnamurthy; Jinming Li; S Liu; Andrew Leask; Rennian Wang
Conditional β1-integrin-deficient mice display impaired pancreatic β cell function.
The Journal of pathology 2011;224(1):45-55.
2011: O A Fajardo; K Thompson; S K Parapuram; S Liu; Andrew Leask
Mithramycin reduces expression of fibro-proliferative mRNAs in human gingival fibroblasts.
Cell proliferation 2011;44(2):166-73.
2011: Andrew Leask
When there's smoke there's…scleroderma: evidence that patients with scleroderma should stop smoking.
Journal of cell communication and signaling 2011;5(1):67-8.
2011: Andrew Leask
Will o' the wisp: CCN4 as a novel molecular target in osteoarthritis.
Journal of cell communication and signaling 2011;5(1):51-2.
2011: Fen Guo; David E Carter; Anuradha Mukhopadhyay; Andrew Leask
Gingival fibroblasts display reduced adhesion and spreading on extracellular matrix: a possible basis for scarless tissue repair?
PloS one 2011;6(11):e27097.
2011: Sunil K Parapuram; Shangxi Liu; Kun Huh; Andrew Leask
Integrin β1 is necessary for the maintenance of corneal structural integrity.
Investigative ophthalmology & visual science 2011;52(11):7799-806.
2011: Luke Morgan-Rowe; Joanna Nikitorowicz; Xu Shiwen; David Abraham; Andrew Leask; Janice Tsui; Richard Stratton
Thrombospondin 1 in hypoxia-conditioned media blocks the growth of human microvascular endothelial cells and is increased in systemic sclerosis tissues.
Fibrogenesis & tissue repair 2011;4():13.
2011: Fen Guo; David E Carter; Andrew Leask
Mechanical tension increases CCN2/CTGF expression and proliferation in gingival fibroblasts via a TGFβ-dependent mechanism.
PloS one 2011;6(5):e19756.
2011: Matthew McCann; Roxana Monemdjou; Sunil K Parapuram; Gemma Perez; Xu Shi-wen; David J Abraham; Leslie J Crofford; Christopher P Denton; Hassan Fahmi; Parisa Ghassemi-Kakroodi; Fumiaki Kojima; Andrew Leask; Shangxi Liu; Johanne Martel-Pelletier; Mohit Kapoor
mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis.
Arthritis research & therapy 2011;13(1):R6.
2011: Shangxi Liu; Xu Shi-wen; David J Abraham; Andrew Leask
CCN2 is required for bleomycin-induced skin fibrosis in mice.
Arthritis and rheumatism 2011;63(1):239-46.
2010: Andrew Leask
B cell block: is rituximab a new possible treatment for systemic sclerosis?
Journal of cell communication and signaling 2010;4(4):201-2.
2010: Andrew Leask
CCN6 (WISP3): a new anti-cancer therapy?
Journal of cell communication and signaling 2010;4(4):199-200.
2010: Andrew Leask
Targeting the jagged/notch pathway: a new treatment for fibrosis?
Journal of cell communication and signaling 2010;4(4):197-8.
2010: Shangxi Liu; Shi-wen Xu; Katrin Blumbach; Mark Eastwood; Christopher P Denton; Beate Eckes; Thomas Krieg; David J Abraham; Andrew Leask
Expression of integrin beta1 by fibroblasts is required for tissue repair in vivo.
Journal of cell science 2010;123(Pt 21):3674-82.
2010: Andrew Leask
When there's smoke there's.....CCN2.
Journal of cell communication and signaling 2010;4(3):157-8.
2010: Andrew Leask; Bernard Perbal
JCCS-A journal for translational research.
Journal of cell communication and signaling 2010;4(3):113.
2010: Nima Aden; Anna Nuttall; Xu Shiwen; Patricia de Winter; Andrew Leask; Carol M Black; Christopher P Denton; David J Abraham; Richard Stratton
Epithelial cells promote fibroblast activation via IL-1alpha in systemic sclerosis.
The Journal of investigative dermatology 2010;130(9):2191-200.
2010: Andrew Leask
It's a knockout: CCN3 suppresses neointimal thickening.
Journal of cell communication and signaling 2010;4(2):109-10.
2010: Andrew Leask
Thrombin-induced CCN2 expression as a target for anti-fibrotic therapy in scleroderma.
Journal of cell communication and signaling 2010;4(2):111-2.
2010: Sonali Sonnylal; Xu Shi-wen; Patricia Leoni; Katherine Naff; Carolyn S Van Pelt; Hiroyuki Nakamura; Andrew Leask; David Abraham; George Bou-Gharios; Benoit de Crombrugghe
Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.
Arthritis and rheumatism 2010;62(5):1523-32.
2010: Shangxi Liu; Reza Taghavi; Andrew Leask
Connective tissue growth factor is induced in bleomycin-induced skin scleroderma.
Journal of cell communication and signaling 2010;4(1):25-30.
2010: Andrew Leask
A sticky situation: CCN1 promotes both proliferation and apoptosis of cancer cells.
Journal of cell communication and signaling 2010;4(1):71-2.
2010: Andrew Leask
Getting to the heart of the matter: CCN2 plays a role in cardiomyocyte hypertrophy.
Journal of cell communication and signaling 2010;4(1):73-4.
2010: Xu Shi-wen; Mark Eastwood; Richard J Stratton; Christopher P Denton; Andrew Leask; David J Abraham
Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts.
Rheumatology (Oxford, England) 2010;49(2):259-63.
2010: Andrew Leask
Towards an anti-fibrotic therapy for scleroderma: targeting myofibroblast differentiation and recruitment.
Fibrogenesis & tissue repair 2010;3():8.
2009: Mohit Kapoor; Matthew McCann; Shangxi Liu; Kun Huh; Christopher P Denton; David J Abraham; Andrew Leask
Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis.
Arthritis and rheumatism 2009;60(9):2822-9.
2009: Shangxi Liu; Mohit Kapoor; Christopher P Denton; David J Abraham; Andrew Leask
Loss of beta1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model.
Arthritis and rheumatism 2009;60(9):2817-21.
2009: Markella Ponticos; holmes alan; Xu Shi-wen; Patricia Leoni; Korsa Khan; Vineeth S Rajkumar; Rachel K Hoyles; George Bou-Gharios; Carol M Black; Christopher P Denton; David J Abraham; Andrew Leask; Gisela E Lindahl
Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.
Arthritis and rheumatism 2009;60(7):2142-55.
2009: Jason S Rockel; Matthew Grol; Suzanne M Bernier; Andrew Leask
Cyclic AMP regulates extracellular matrix gene expression and metabolism in cultured primary rat chondrocytes.
Matrix biology : journal of the International Society for Matrix Biology 2009;28(6):354-64.
2009: Andrew Leask
Yin and Yang: CCN3 inhibits the pro-fibrotic effects of CCN2.
Journal of cell communication and signaling 2009;3(2):161-2.
2009: Andrew Leask
What's in an intron? CCN1 mRNA splicing in cancer.
Journal of cell communication and signaling 2009;3(2):151-2.
2009: Xu Shiwen; Andrew Leask; David J Abraham; C Fonseca
Endothelin receptor selectivity: evidence from in vitro and pre-clinical models of scleroderma.
European journal of clinical investigation 2009;39 Suppl 2():19-26.
2009: Andrew Leask
Death of a tumor: targeting CCN in pancreatic cancer.
Journal of cell communication and signaling 2009;3(2):159-60.
2009: Andrew Leask; Sunil K Parapuram; Xu Shi-wen; David J Abraham
Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?
Journal of cell communication and signaling 2009;3(2):89-94.
2009: Shangxi Liu; Mohit Kapoor; Andrew Leask
Rac1 expression by fibroblasts is required for tissue repair in vivo.
The American journal of pathology 2009;174(5):1847-56.
2009: Xu Shiwen; Vineeth Rajkumar; Christopher P Denton; Andrew Leask; David J Abraham
Pericytes display increased CCN2 expression upon culturing.
Journal of cell communication and signaling 2009;3(1):61-4.
2009: Shaoqiong Chen; Andrew Leask
Wnt 10b activates the CCN2 promoter in NIH 3T3 fibroblasts through the Smad response element.
Journal of cell communication and signaling 2009;3(1):57-9.
2009: Andrew Leask
Trial by CCN2: a standardized test for fibroproliferative disease?
Journal of cell communication and signaling 2009;3(1):87-8.
2009: Anita Woods; D Pala; Laura Kennedy; S McLean; J S Rockel; guoyan wang; Andrew Leask; Frank Beier
Rac1 signaling regulates CTGF/CCN2 gene expression via TGFbeta/Smad signaling in chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(3):406-13.
2009: Shi-wen Xu; Shangxi Liu; Mark Eastwood; Sonali Sonnylal; Christopher P Denton; David J Abraham; Andrew Leask
Rac inhibition reverses the phenotype of fibrotic fibroblasts.
PloS one 2009;4(10):e7438.
2009: Andrew Leask
Signaling in fibrosis: targeting the TGF beta, endothelin-1 and CCN2 axis in scleroderma.
Frontiers in bioscience (Elite edition) 2009;1():115-22.
2009: Jason S Rockel; Suzanne M Bernier; Andrew Leask
Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK/ERK signalling.
Arthritis research & therapy 2009;11(1):R8.
2009: Xu Shi-wen; Sunil K Parapuram; Daphne Pala; Yunliang Chen; David E Carter; Mark Eastwood; Christopher P Denton; David J Abraham; Andrew Leask
Requirement of transforming growth factor beta-activated kinase 1 for transforming growth factor beta-induced alpha-smooth muscle actin expression and extracellular matrix contraction in fibroblasts.
Arthritis and rheumatism 2009;60(1):234-41.
2008: Andrew Leask
The skinny on CCN2.
Journal of cell communication and signaling 2008;2(3-4):93-4.
2008: N Aden; Xu Shiwen; D Aden; C Black; A Nuttall; Christopher P Denton; Andrew Leask; D Abraham; Richard Stratton
Proteomic analysis of scleroderma lesional skin reveals activated wound healing phenotype of epidermal cell layer.
Rheumatology (Oxford, England) 2008;47(12):1754-60.
2008: Andrew Leask; Xu Shi-wen; Korsa Khan; Yunliang Chen; holmes alan; Mark Eastwood; Christopher P Denton; Carol M Black; David J Abraham
Loss of protein kinase Cepsilon results in impaired cutaneous wound closure and myofibroblast function.
Journal of cell science 2008;121(Pt 20):3459-67.
2008: Mohit Kapoor; Shangxi Liu; Xu Shi-wen; Kun Huh; Matthew McCann; Christopher P Denton; James R Woodgett; David J Abraham; Andrew Leask
GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism.
The Journal of clinical investigation 2008;118(10):3279-90.
2008: Andrew Leask
Targeting the TGFbeta, endothelin-1 and CCN2 axis to combat fibrosis in scleroderma.
Cellular signalling 2008;20(8):1409-14.
2008: Shangxi Liu; Mohit Kapoor; Xu Shi-wen; Laura Kennedy; Christopher P Denton; Glogauer Michael; David J Abraham; Andrew Leask
Role of Rac1 in a bleomycin-induced scleroderma model using fibroblast-specific Rac1-knockout mice.
Arthritis and rheumatism 2008;58(7):2189-95.
2008: Andrew Leask; Daphne Pala; Shaoqiong Chen; David R Brigstock
Regulation of CCN2 mRNA expression and promoter activity in activated hepatic stellate cells.
Journal of cell communication and signaling 2008;2(1-2):49-56.
2008: Andrew Leask
CCN2 YAPs at cancer.
Journal of cell communication and signaling 2008;2(1-2):47-8.
2008: Laura Kennedy; Sunil Parapuram; Jill Greenspoon; Andrew Leask
Ceramide inhibits CCN2 expression in fibroblasts.
Journal of cell communication and signaling 2008;2(1-2):19-23.
2008: Andrew Leask
The Starbuck stops here: it's a Smad world.
Journal of cell communication and signaling 2008;2(1-2):1-2.
2008: Laura Kennedy; Xu Shi-wen; David E Carter; David J Abraham; Andrew Leask
Fibroblast adhesion results in the induction of a matrix remodeling gene expression program.
Matrix biology : journal of the International Society for Matrix Biology 2008;27(4):274-81.
2008: Daphne Pala; Mohit Kapoor; Anita Woods; Laura Kennedy; Shangxi Liu; Shioqiong Chen; Laura Bursell; Karen M Lyons; David E Carter; Frank Beier; Andrew Leask
Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2.
The Journal of biological chemistry 2008;283(14):9239-47.
2008: Xu Shi-wen; Andrew Leask; David Abraham
Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis.
Cytokine & growth factor reviews 2008;19(2):133-44.
2008: Yunliang Chen; Andrew Leask; David J Abraham; Daphne Pala; Xu Shiwen; Korsa Khan; Shangxi Liu; David E Carter; Sarah Wilcox-Adelman; Paul Goetinck; Christopher P Denton; Carol M Black; Andrew A Pitsillides; Catherine E Sarraf; Mark Eastwood
Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts.
Arthritis and rheumatism 2008;58(2):577-85.
2008: Mohit Kapoor; Shangxi Liu; Kun Huh; Sunil Parapuram; Laura Kennedy; Andrew Leask
Connective tissue growth factor promoter activity in normal and wounded skin.
Fibrogenesis & tissue repair 2008;1(1):3.
2007: Shaoqiong Chen; Sarah McLean; David E Carter; Andrew Leask
The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblasts.
Journal of cell communication and signaling 2007;1(3-4):175-83.
2007: Andrew Leask
CCN3: A novel function in vivo.
Journal of cell communication and signaling 2007;1(3-4):227-8.
2007: Xu Shi-wen; Laura Kennedy; Elisabetta A Renzoni; George Bou-Gharios; Roland M Du Bois; Carol M Black; Christopher P Denton; David J Abraham; Andrew Leask
Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.
Arthritis and rheumatism 2007;56(12):4189-94.
2007: Xu Shi-wen; Elisabetta A Renzoni; Laura Kennedy; Sarah Howat; Yunliang Chen; Jeremy Pearson; George Bou-Gharios; Michael R Dashwood; Roland M Du Bois; Carol M Black; Christopher P Denton; David J Abraham; Andrew Leask
Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts.
Matrix biology : journal of the International Society for Matrix Biology 2007;26(8):625-32.
2007: Melissa Pickles; Andrew Leask
Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK.
Journal of cell communication and signaling 2007;1(2):85-90.
2007: Shangxi Liu; Shi-wen Xu; Laura Kennedy; Daphne Pala; Yunliang Chen; Mark Eastwood; David E Carter; Carol M Black; David J Abraham; Andrew Leask
FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype.
Molecular biology of the cell 2007;18(6):2169-78.
2007: Andrew Leask
TGFbeta, cardiac fibroblasts, and the fibrotic response.
Cardiovascular research 2007;74(2):207-12.
2007: Laura Kennedy; Shangxi Liu; Xu Shi-wen; Yunliang Chen; Mark Eastwood; Mojhgan Sabetkar; David E Carter; Karen M Lyons; Carol M Black; David J Abraham; Andrew Leask
CCN2 is necessary for the function of mouse embryonic fibroblasts.
Experimental cell research 2007;313(5):952-64.
2007: Laura Bursell; Anita Woods; Claudine G James; Daphne Pala; Andrew Leask; Frank Beier
Src kinase inhibition promotes the chondrocyte phenotype.
Arthritis research & therapy 2007;9(5):R105.
2006: Andrew Leask; David J Abraham
All in the CCN family: essential matricellular signaling modulators emerge from the bunker.
Journal of cell science 2006;119(Pt 23):4803-10.
2006: Xu Shi-wen; Fernando Rodríguez-Pascual; Santiago Lamas; holmes alan; Sarah Howat; Jeremy Pearson; Michael R Dashwood; Roland M Du Bois; Christopher P Denton; Carol M Black; David J Abraham; Andrew Leask
Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors.
Molecular and cellular biology 2006;26(14):5518-27.
2006: Xu Shi-wen; Lee-Anne Stanton; Laura Kennedy; Daphne Pala; Yunliang Chen; Sarah Howat; Elisabetta A Renzoni; David E Carter; George Bou-Gharios; Richard J Stratton; Jeremy Pearson; Frank Beier; Karen M Lyons; Carol M Black; David J Abraham; Andrew Leask
CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.
The Journal of biological chemistry 2006;281(16):10715-26.
2006: Yunliang Chen; Xu Shi-wen; Mark Eastwood; Carol M Black; Christopher P Denton; Andrew Leask; David J Abraham
Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts.
Arthritis and rheumatism 2006;54(4):1309-16.
2006: Andrew Leask
Scar wars: is TGFbeta the phantom menace in scleroderma?
Arthritis research & therapy 2006;8(4):213.
2006: Jonathan P van Beek; Laura Kennedy; Jason S Rockel; Suzanne M Bernier; Andrew Leask
The induction of CCN2 by TGFbeta1 involves Ets-1.
Arthritis research & therapy 2006;8(2):R36.
2005: Yunliang Chen; Xu Shi-wen; Jonathan van Beek; Laura Kennedy; Marilyn McLeod; Elisabetta A Renzoni; George Bou-Gharios; Sarah Wilcox-Adelman; Paul F Goetinck; Mark Eastwood; Carol M Black; David J Abraham; Andrew Leask
Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.
The American journal of pathology 2005;167(6):1699-711.
2005: M Dziadzio; W Usinger; Andrew Leask; D Abraham; Carol M Black; C Denton; Richard Stratton
N-terminal connective tissue growth factor is a marker of the fibrotic phenotype in scleroderma.
QJM : monthly journal of the Association of Physicians 2005;98(7):485-92.
2005: Christopher P Denton; Gisela E Lindahl; Korsa Khan; Xu Shiwen; Voon H Ong; Nicholas J Gaspar; Konstantinos Lazaridis; Dylan R Edwards; Andrew Leask; Mark Eastwood; Patricia Leoni; Elisabetta A Renzoni; George Bou-Gharios; David J Abraham; Carol M Black
Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).
The Journal of biological chemistry 2005;280(16):16053-65.
2004: Yunliang Chen; David J Abraham; Xu Shi-wen; Jeremy Pearson; Carol M Black; Karen M Lyons; Andrew Leask
CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin.
Molecular biology of the cell 2004;15(12):5635-46.
2004: Andrew Leask
Transcriptional profiling of the scleroderma fibroblast reveals a potential role for connective tissue growth factor (CTGF) in pathological fibrosis.
The Keio journal of medicine 2004;53(2):74-7.
2004: Xu Shi-wen; Yunliang Chen; Christopher P Denton; Mark Eastwood; Elisabetta A Renzoni; George Bou-Gharios; Jeremy Pearson; Michael R Dashwood; Roland M Du Bois; Carol M Black; Andrew Leask; David J Abraham
Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.
Molecular biology of the cell 2004;15(6):2707-19.
2004: Shi-wen Xu; Sarah Howat; Elisabetta A Renzoni; holmes alan; Jeremy Pearson; Michael R Dashwood; George Bou-Gharios; Christopher P Denton; Roland M Du Bois; Carol M Black; Andrew Leask; David J Abraham
Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.
The Journal of biological chemistry 2004;279(22):23098-103.
2004: Andrew Leask; David J Abraham
TGF-beta signaling and the fibrotic response.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(7):816-27.
2004: Elisabetta A Renzoni; David J Abraham; Sarah Howat; Xu Shi-wen; Piersante Sestini; George Bou-Gharios; Athol U Wells; Srihari Veeraraghavan; Andrew G Nicholson; Christopher P Denton; Andrew Leask; Jeremy Pearson; Carol M Black; Kenneth I Welsh; Roland M Du Bois
Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts.
Respiratory research 2004;5():24.
2004: Andrew Leask; Christopher P Denton; David J Abraham
Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma.
The Journal of investigative dermatology 2004;122(1):1-6.
2003: holmes alan; David J Abraham; Youjun Chen; Christopher P Denton; Xu Shi-wen; Carol M Black; Andrew Leask
Constitutive connective tissue growth factor expression in scleroderma fibroblasts is dependent on Sp1.
The Journal of biological chemistry 2003;278(43):41728-33.
2002: Richard Stratton; Vineeth Rajkumar; Markella Ponticos; Blake Nichols; Xu Shiwen; Carol M Black; David J Abraham; Andrew Leask
Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(14):1949-51.
2002: Ingrid E Blom; roel goldschmeding; Andrew Leask
Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy?
Matrix biology : journal of the International Society for Matrix Biology 2002;21(6):473-82.
2002: Youjun Chen; Ingrid E Blom; Susan Sa; roel goldschmeding; David J Abraham; Andrew Leask
CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC.
Kidney international 2002;62(4):1149-59.
2002: Andrew Leask; David J Abraham; D R Finlay; holmes alan; D Pennington; Xu Shi-wen; Y Chen; K Venstrom; X Dou; Markella Ponticos; C Black; C Bernabeu; J K Jackman; P R Findell; M Kari Connolly
Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts.
Arthritis and rheumatism 2002;46(7):1857-65.
2002: Andrew Leask; holmes alan; David J Abraham
Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis.
Current rheumatology reports 2002;4(2):136-42.
2001: Y Chen; P Segarini; F Raoufi; D Bradham; Andrew Leask
Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome.
Experimental cell research 2001;271(1):109-17.
2001: Richard Stratton; Xu Shiwen; G Martini; holmes alan; Andrew Leask; T Haberberger; G R Martin; Carol M Black; D Abraham
Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients.
The Journal of clinical investigation 2001;108(2):241-50.
2001: Andrew Leask; Susan Sa; holmes alan; Xu Shiwen; C M Black; David J Abraham
The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts.
Molecular pathology : MP 2001;54(3):180-3.
2001: holmes alan; David J Abraham; Susan Sa; Xu Shiwen; Carol M Black; Andrew Leask
CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling.
The Journal of biological chemistry 2001;276(14):10594-601.
2000: Xu Shi-wen; D Pennington; holmes alan; Andrew Leask; D Bradham; J R Beauchamp; Carmen Fonseca; Roland M Du Bois; G R Martin; Carol M Black; David J Abraham
Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis.
Experimental cell research 2000;259(1):213-24.
2000: David J Abraham; Xu Shiwen; Carol M Black; Susan Sa; Y Xu; Andrew Leask
Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts.
The Journal of biological chemistry 2000;275(20):15220-5.
1998: Andrew Leask; Tim Stearns
Expression of amino- and carboxyl-terminal gamma- and alpha-tubulin mutants in cultured epithelial cells.
The Journal of biological chemistry 1998;273(5):2661-8.
1997: Andrew Leask; Karl Obrietan; Tim Stearns
Synaptically coupled central nervous system neurons lack centrosomal gamma-tubulin.
Neuroscience letters 1997;229(1):17-20.
1995: Paul M Macdonald; Andrew Leask; K Kerr
exl protein specifically binds BLE1, a bicoid mRNA localization element, and is required for one phase of its activity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(23):10787-91.
1993: Paul M Macdonald; K Kerr; J L Smith; Andrew Leask
RNA regulatory element BLE1 directs the early steps of bicoid mRNA localization.
Development (Cambridge, England) 1993;118(4):1233-43.