Andrew Leask

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Kapoor Mohit; McCann Matthew; Liu Shangxi; Huh Kun; Denton Christopher P; Abraham David J; Leask Andrew
Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis.
Liu Shangxi; Kapoor Mohit; Denton Christopher P; Abraham David J; Leask Andrew
Loss of beta1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model.
Ponticos Markella; Holmes Alan M; Shi-wen Xu; Leoni Patricia; Khan Korsa; Rajkumar Vineeth S; Hoyles Rachel K; Bou-Gharios George; Black Carol M; Denton Christopher P; Abraham David J; Leask Andrew; Lindahl Gisela E
Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.

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2009: Kapoor Mohit; McCann Matthew; Liu Shangxi; Huh Kun; Denton Christopher P; Abraham David J; Leask Andrew
Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis.
Arthritis and rheumatism 2009;60(9):2822-9.
2009: Liu Shangxi; Kapoor Mohit; Denton Christopher P; Abraham David J; Leask Andrew
Loss of beta1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model.
Arthritis and rheumatism 2009;60(9):2817-21.
2009: Ponticos Markella; Holmes Alan M; Shi-wen Xu; Leoni Patricia; Khan Korsa; Rajkumar Vineeth S; Hoyles Rachel K; Bou-Gharios George; Black Carol M; Denton Christopher P; Abraham David J; Leask Andrew; Lindahl Gisela E
Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.
Arthritis and rheumatism 2009;60(7):2142-55.
2009: Rockel Jason S; Grol Matthew; Bernier Suzanne M; Leask Andrew
Cyclic AMP regulates extracellular matrix gene expression and metabolism in cultured primary rat chondrocytes.
Matrix biology : journal of the International Society for Matrix Biology 2009;28(6):354-64.
2009: Liu Shangxi; Kapoor Mohit; Leask Andrew
Rac1 expression by fibroblasts is required for tissue repair in vivo.
The American journal of pathology 2009;174(5):1847-56.
2009: Shiwen Xu; Rajkumar Vineeth; Denton Christopher P; Leask Andrew; Abraham David J
Pericytes display increased CCN2 expression upon culturing.
Journal of cell communication and signaling 2009;3(1):61-4.
2009: Chen Shaoqiong; Leask Andrew
Wnt 10b activates the CCN2 promoter in NIH 3T3 fibroblasts through the Smad response element.
Journal of cell communication and signaling 2009;3(1):57-9.
2009: Woods A; Pala D; Kennedy L; McLean S; Rockel J S; Wang G; Leask A; Beier F
Rac1 signaling regulates CTGF/CCN2 gene expression via TGFbeta/Smad signaling in chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(3):406-13.
2009: Shi-wen Xu; Parapuram Sunil K; Pala Daphne; Chen Yunliang; Carter David E; Eastwood Mark; Denton Christopher P; Abraham David J; Leask Andrew
Requirement of transforming growth factor beta-activated kinase 1 for transforming growth factor beta-induced alpha-smooth muscle actin expression and extracellular matrix contraction in fibroblasts.
Arthritis and rheumatism 2009;60(1):234-41.
2009: Xu Shi-wen; Liu Shangxi; Eastwood Mark; Sonnylal Sonali; Denton Christopher P; Abraham David J; Leask Andrew
Rac inhibition reverses the phenotype of fibrotic fibroblasts.
PloS one 2009;4(10):e7438.
2009: Leask Andrew
Signaling in fibrosis: Targeting the TGF beta, endothelin-1 and CCN2 axis in scleroderma.
Frontiers in bioscience (elite edition) 2009;1():115-22.
2009: Rockel Jason S; Bernier Suzanne M; Leask Andrew
Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK/ERK signalling.
Arthritis research & therapy 2009;11(1):R8.
2008: Leask Andrew
The skinny on CCN2.
Journal of cell communication and signaling 2008;2(3-4):93-4.
2008: Aden N; Shiwen X; Aden D; Black C; Nuttall A; Denton C P; Leask A; Abraham D; Stratton R
Proteomic analysis of scleroderma lesional skin reveals activated wound healing phenotype of epidermal cell layer.
Rheumatology (Oxford, England) 2008;47(12):1754-60.
2008: Leask Andrew; Shi-Wen Xu; Khan Korsa; Chen Yunliang; Holmes Alan; Eastwood Mark; Denton Christopher P; Black Carol M; Abraham David J
Loss of protein kinase Cepsilon results in impaired cutaneous wound closure and myofibroblast function.
Journal of cell science 2008;121(Pt 20):3459-67.
2008: Kapoor Mohit; Liu Shangxi; Shi-wen Xu; Huh Kun; McCann Matthew; Denton Christopher P; Woodgett James R; Abraham David J; Leask Andrew
GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism.
The Journal of clinical investigation 2008;118(10):3279-90.
2008: Leask Andrew
Targeting the TGFbeta, endothelin-1 and CCN2 axis to combat fibrosis in scleroderma.
Cellular signalling 2008;20(8):1409-14.
2008: Liu Shangxi; Kapoor Mohit; Shi-wen Xu; Kennedy Laura; Denton Christopher P; Glogauer Michael; Abraham David J; Leask Andrew
Role of Rac1 in a bleomycin-induced scleroderma model using fibroblast-specific Rac1-knockout mice.
Arthritis and rheumatism 2008;58(7):2189-95.
2008: Kennedy Laura; Parapuram Sunil; Greenspoon Jill; Leask Andrew
Ceramide inhibits CCN2 expression in fibroblasts.
Journal of cell communication and signaling 2008;2(1-2):19-23.
2008: Kennedy Laura; Shi-Wen Xu; Carter David E; Abraham David J; Leask Andrew
Fibroblast adhesion results in the induction of a matrix remodeling gene expression program.
Matrix biology : journal of the International Society for Matrix Biology 2008;27(4):274-81.
2008: Shi-Wen Xu; Leask Andrew; Abraham David
Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis.
Cytokine & growth factor reviews 2008;19(2):133-44.
2008: Pala Daphne; Kapoor Mohit; Woods Anita; Kennedy Laura; Liu Shangxi; Chen Shioqiong; Bursell Laura; Lyons Karen M; Carter David E; Beier Frank; Leask Andrew
Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2.
The Journal of biological chemistry 2008;283(14):9239-47.
2008: Chen Yunliang; Leask Andrew; Abraham David J; Pala Daphne; Shiwen Xu; Khan Korsa; Liu Shangxi; Carter David E; Wilcox-Adelman Sarah; Goetinck Paul; Denton Christopher P; Black Carol M; Pitsillides Andrew A; Sarraf Catherine E; Eastwood Mark
Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts.
Arthritis and rheumatism 2008;58(2):577-85.
2007: Chen Shaoqiong; McLean Sarah; Carter David E; Leask Andrew
The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblasts.
Journal of cell communication and signaling 2007;1(3-4):175-83.
2007: Shi-wen Xu; Kennedy Laura; Renzoni Elisabetta A; Bou-Gharios George; du Bois Roland M; Black Carol M; Denton Christopher P; Abraham David J; Leask Andrew
Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.
Arthritis and rheumatism 2007;56(12):4189-94.
2007: Shi-Wen Xu; Renzoni Elisabetta A; Kennedy Laura; Howat Sarah; Chen Yunliang; Pearson Jeremy D; Bou-Gharios George; Dashwood Michael R; du Bois Roland M; Black Carol M; Denton Christopher P; Abraham David J; Leask Andrew
Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts.
Matrix biology : journal of the International Society for Matrix Biology 2007;26(8):625-32.
2007: Pickles Melissa; Leask Andrew
Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK.
Journal of cell communication and signaling 2007;1(2):85-90.
2007: Liu Shangxi; Xu Shi-wen; Kennedy Laura; Pala Daphne; Chen Yunliang; Eastwood Mark; Carter David E; Black Carol M; Abraham David J; Leask Andrew
FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype.
Molecular biology of the cell 2007;18(6):2169-78.
2007: Leask Andrew
TGFbeta, cardiac fibroblasts, and the fibrotic response.
Cardiovascular research 2007;74(2):207-12.
2007: Kennedy Laura; Liu Shangxi; Shi-Wen Xu; Chen Yunliang; Eastwood Mark; Sabetkar Mojhgan; Carter David E; Lyons Karen M; Black Carol M; Abraham David J; Leask Andrew
CCN2 is necessary for the function of mouse embryonic fibroblasts.
Experimental cell research 2007;313(5):952-64.
2007: Bursell Laura; Woods Anita; James Claudine G; Pala Daphne; Leask Andrew; Beier Frank
Src kinase inhibition promotes the chondrocyte phenotype.
Arthritis research & therapy 2007;9(5):R105.
2006: Leask Andrew; Abraham David J
All in the CCN family: essential matricellular signaling modulators emerge from the bunker.
Journal of cell science 2006;119(Pt 23):4803-10.
2006: Shi-Wen Xu; Rodríguez-Pascual Fernando; Lamas Santiago; Holmes Alan; Howat Sarah; Pearson Jeremy D; Dashwood Michael R; du Bois Roland M; Denton Christopher P; Black Carol M; Abraham David J; Leask Andrew
Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors.
Molecular and cellular biology 2006;26(14):5518-27.
2006: Chen Yunliang; Shi-wen Xu; Eastwood Mark; Black Carol M; Denton Christopher P; Leask Andrew; Abraham David J
Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts.
Arthritis and rheumatism 2006;54(4):1309-16.
2006: Shi-wen Xu; Stanton Lee Anne; Kennedy Laura; Pala Daphne; Chen Yunliang; Howat Sarah L; Renzoni Elisabetta A; Carter David E; Bou-Gharios George; Stratton Richard J; Pearson Jeremy D; Beier Frank; Lyons Karen M; Black Carol M; Abraham David J; Leask Andrew
CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.
The Journal of biological chemistry 2006;281(16):10715-26.
2006: Leask Andrew
Scar wars: is TGFbeta the phantom menace in scleroderma?
Arthritis research & therapy 2006;8(4):213.
2006: Van Beek Jonathan P; Kennedy Laura; Rockel Jason S; Bernier Suzanne M; Leask Andrew
The induction of CCN2 by TGFbeta1 involves Ets-1.
Arthritis research & therapy 2006;8(2):R36.
2005: Chen Yunliang; Shi-Wen Xu; van Beek Jonathan; Kennedy Laura; McLeod Marilyn; Renzoni Elisabetta A; Bou-Gharios George; Wilcox-Adelman Sarah; Goetinck Paul F; Eastwood Mark; Black Carol M; Abraham David J; Leask Andrew
Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.
The American journal of pathology 2005;167(6):1699-711.
2005: Dziadzio M; Usinger W; Leask A; Abraham D; Black C M; Denton C; Stratton R
N-terminal connective tissue growth factor is a marker of the fibrotic phenotype in scleroderma.
QJM : monthly journal of the Association of Physicians 2005;98(7):485-92.
2005: Denton Christopher P; Lindahl Gisela E; Khan Korsa; Shiwen Xu; Ong Voon H; Gaspar Nicholas J; Lazaridis Konstantinos; Edwards Dylan R; Leask Andrew; Eastwood Mark; Leoni Patricia; Renzoni Elisabetta A; Bou Gharios George; Abraham David J; Black Carol M
Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).
The Journal of biological chemistry 2005;280(16):16053-65.
2004: Chen Yunliang; Abraham David J; Shi-Wen Xu; Pearson Jeremy D; Black Carol M; Lyons Karen M; Leask Andrew
CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin.
Molecular biology of the cell 2004;15(12):5635-46.
2004: Leask Andrew
Transcriptional profiling of the scleroderma fibroblast reveals a potential role for connective tissue growth factor (CTGF) in pathological fibrosis.
The Keio journal of medicine 2004;53(2):74-7.
2004: Shi-Wen Xu; Chen Yunliang; Denton Christopher P; Eastwood Mark; Renzoni Elisabetta A; Bou-Gharios George; Pearson Jeremy D; Dashwood Michael; du Bois Roland M; Black Carol M; Leask Andrew; Abraham David J
Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.
Molecular biology of the cell 2004;15(6):2707-19.
2004: Leask Andrew; Abraham David J
TGF-beta signaling and the fibrotic response.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(7):816-27.
2004: Xu Shi-wen; Howat Sarah L; Renzoni Elisabetta A; Holmes Alan; Pearson Jeremy D; Dashwood Michael R; Bou-Gharios George; Denton Christopher P; du Bois Roland M; Black Carol M; Leask Andrew; Abraham David J
Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.
The Journal of biological chemistry 2004;279(22):23098-103.
2004: Leask Andrew; Denton Christopher P; Abraham David J
Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma.
The Journal of investigative dermatology 2004;122(1):1-6.
2004: Renzoni Elisabetta A; Abraham David J; Howat Sarah; Shi-Wen Xu; Sestini Piersante; Bou-Gharios George; Wells Athol U; Veeraraghavan Srihari; Nicholson Andrew G; Denton Christopher P; Leask Andrew; Pearson Jeremy D; Black Carol M; Welsh Kenneth I; du Bois Roland M
Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts.
Respiratory research 2004;5():24.
2003: Holmes Alan; Abraham David J; Chen Youjun; Denton Christopher; Shi-wen Xu; Black Carol M; Leask Andrew
Constitutive connective tissue growth factor expression in scleroderma fibroblasts is dependent on Sp1.
The Journal of biological chemistry 2003;278(43):41728-33.
2002: Stratton Richard; Rajkumar Vineeth; Ponticos Markella; Nichols Blake; Shiwen Xu; Black Carol M; Abraham David J; Leask Andrew
Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(14):1949-51.
2002: Blom Ingrid E; Goldschmeding Roel; Leask Andrew
Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy?
Matrix biology : journal of the International Society for Matrix Biology 2002;21(6):473-82.
2002: Chen Youjun; Blom Ingrid E; Sa Susan; Goldschmeding Roel; Abraham David J; Leask Andrew
CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC.
Kidney international 2002;62(4):1149-59.
2002: Leask A; Abraham D J; Finlay D R; Holmes A; Pennington D; Shi-Wen X; Chen Y; Venstrom K; Dou X; Ponticos M; Black C; Bernabeu C; Jackman J K; Findell P R; Connolly M K
Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts.
Arthritis and rheumatism 2002;46(7):1857-65.
2002: Leask Andrew; Holmes Alan; Abraham David J
Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis.
Current rheumatology reports 2002;4(2):136-42.
2001: Chen Y; Segarini P; Raoufi F; Bradham D; Leask A
Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome.
Experimental cell research 2001;271(1):109-17.
2001: Stratton R; Shiwen X; Martini G; Holmes A; Leask A; Haberberger T; Martin G R; Black C M; Abraham D
Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients.
The Journal of clinical investigation 2001;108(2):241-50.
2001: Leask A; Sa S; Holmes A; Shiwen X; Black C M; Abraham D J
The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts.
Molecular pathology : MP 2001;54(3):180-3.
2001: Holmes A; Abraham D J; Sa S; Shiwen X; Black C M; Leask A
CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling.
The Journal of biological chemistry 2001;276(14):10594-601.
2000: Shi-wen X; Pennington D; Holmes A; Leask A; Bradham D; Beauchamp J R; Fonseca C; du Bois R M; Martin G R; Black C M; Abraham D J
Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis.
Experimental cell research 2000;259(1):213-24.
2000: Abraham D J; Shiwen X; Black C M; Sa S; Xu Y; Leask A
Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts.
The Journal of biological chemistry 2000;275(20):15220-5.
1998: Leask A; Stearns T
Expression of amino- and carboxyl-terminal gamma- and alpha-tubulin mutants in cultured epithelial cells.
The Journal of biological chemistry 1998;273(5):2661-8.
1997: Leask A; Obrietan K; Stearns T
Synaptically coupled central nervous system neurons lack centrosomal gamma-tubulin.
Neuroscience letters 1997;229(1):17-20.
1995: MacDonald P M; Leask A; Kerr K
exl protein specifically binds BLE1, a bicoid mRNA localization element, and is required for one phase of its activity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(23):10787-91.
1993: Macdonald P M; Kerr K; Smith J L; Leask A
RNA regulatory element BLE1 directs the early steps of bicoid mRNA localization.
Development (Cambridge, England) 1993;118(4):1233-43.

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Andrew Leask

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