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Margitta Lebofsky

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Mitchell R McGill; Hye-Ryun K Norris; Douglas E Rollins; Matthew H Slawson; Diana G Wilkins; C David Williams; Yuchao Xie; Mary Lynn Bajt; Margitta Lebofsky; Hartmut Jaeschke
Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose-response, mechanisms, and clinical implications.
Yuchao Xie; Margitta Lebofsky; Mitchell R McGill; Anup Ramachandran; C David Williams; Hartmut Jaeschke
Purinergic receptor antagonist a438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation.
Hong-Min Ni; Hartmut Jaeschke; Margitta Lebofsky; Mitchell R McGill; Udayan Apte; Nikki Boggess; Prachi Borude; Wen-Xing Ding
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.

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2013: Mitchell R McGill; Hye-Ryun K Norris; Douglas E Rollins; Matthew H Slawson; Diana G Wilkins; C David Williams; Yuchao Xie; Mary Lynn Bajt; Margitta Lebofsky; Hartmut Jaeschke
Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose-response, mechanisms, and clinical implications.
Toxicology and applied pharmacology 2013;269(3):240-9.
2013: Yuchao Xie; Margitta Lebofsky; Mitchell R McGill; Anup Ramachandran; C David Williams; Hartmut Jaeschke
Purinergic receptor antagonist a438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation.
Toxicological sciences : an official journal of the Society of Toxicology 2013;131(1):325-35.
2012: Hong-Min Ni; Hartmut Jaeschke; Margitta Lebofsky; Mitchell R McGill; Udayan Apte; Nikki Boggess; Prachi Borude; Wen-Xing Ding
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 2012;127(2):438-50.
2011: Mary Lynn Bajt; Anwar Farhood; Margitta Lebofsky; John J Lemasters; Anup Ramachandran; Hui-Min Yan; Hartmut Jaeschke
Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2011;122(2):598-605.
2011: Anup Ramachandran; Margitta Lebofsky; Steven A Weinman; Hartmut Jaeschke
The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity.
Toxicology and applied pharmacology 2011;251(3):226-33.
2011: Anup Ramachandran; Margitta Lebofsky; Christopher P Baines; John J Lemasters; Hartmut Jaeschke
Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury.
Free radical research 2011;45(2):156-64.
2010: Peter Fickert; Andrea Thueringer; Tarek Moustafa; Dagmar Silbert; Judith Gumhold; Oleksiy Tsybrovskyy; Margitta Lebofsky; Hartmut Jaeschke; Helmut Denk; Michael Trauner
The role of osteopontin and tumor necrosis factor alpha receptor-1 in xenobiotic-induced cholangitis and biliary fibrosis in mice.
Laboratory investigation; a journal of technical methods and pathology 2010;90(6):844-52.
2009: Sven Schüngel; Laura Elisa Buitrago-Molina; Padmavathi devi Nalapareddy; Margitta Lebofsky; Michael P Manns; Hartmut Jaeschke; Atan Gross; Arndt Vogel
The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers.
Hepatology (Baltimore, Md.) 2009;50(5):1558-66.
2009: Ji-Young Hong; Margitta Lebofsky; Anwar Farhood; Hartmut Jaeschke
Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation.
American journal of physiology. Gastrointestinal and liver physiology 2009;296(3):G572-81.
2005: Shakil A Saghir; Margitta Lebofsky; David M Pinson; Karl K Rozman
Validation of Haber's Rule (dose x time = constant) in rats and mice for monochloroacetic acid and 2,3,7,8-tetrachlorodibenzo-p-dioxin under conditions of kinetic steady state.
Toxicology 2005;215(1-2):48-56.
2005: Karl K Rozman; Margitta Lebofsky; David M Pinson
Chronic toxicity and carcinogenicity of 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin displays a distinct dose/time toxicity threshold (c x t = k) and a life-prolonging subthreshold effect.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(5):729-40.
2005: Claire R Croutch; Margitta Lebofsky; Karl-Werner Schramm; Paul F Terranova; Karl K Rozman
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin (HxCDD) alter body weight by decreasing insulin-like growth factor I (IGF-I) signaling.
Toxicological sciences : an official journal of the Society of Toxicology 2005;85(1):560-71.
2004: Matti Viluksela; Atso Raasmaja; Margitta Lebofsky; Bernhard U Stahl; Karl K Rozman
Tissue-specific effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the activity of 5'-deiodinases I and II in rats.
Toxicology letters 2004;147(2):133-42.