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Philippe Leboulch

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Olivier Goupille; Marine Granger; Zahra Kadri; Philippe Leboulch; Carine Lefèvre; Leila Maouche-Chrétien; Tipparat Penglong; Suthat Fucharoen; Stany Chrétien
BET bromodomain inhibition rescues erythropoietin differentiation of human erythroleukemia cell line UT7.
Els Verhoeyen; Roger Le Grand; Francis Relouzat; Marie Cambot; François-Loïc Cosset; Caroline Costa; Anne Dubart Kupperschmitt; Christophe Joubert; Philippe Leboulch; Faézeh Legrand; Didier Nègre; Stephane Prost
Stem cell factor-displaying simian immunodeficiency viral vectors together with a low conditioning regimen allow for long-term engraftment of gene-marked autologous hematopoietic stem cells in macaques.
Emmanuel Payen; Philippe Leboulch
Advances in stem cell transplantation and gene therapy in the β-hemoglobinopathies.

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2012: Olivier Goupille; Marine Granger; Zahra Kadri; Philippe Leboulch; Carine Lefèvre; Leila Maouche-Chrétien; Tipparat Penglong; Suthat Fucharoen; Stany Chrétien
BET bromodomain inhibition rescues erythropoietin differentiation of human erythroleukemia cell line UT7.
Biochemical and biophysical research communications 2012;429(1-2):1-5.
2012: Els Verhoeyen; Roger Le Grand; Francis Relouzat; Marie Cambot; François-Loïc Cosset; Caroline Costa; Anne Dubart Kupperschmitt; Christophe Joubert; Philippe Leboulch; Faézeh Legrand; Didier Nègre; Stephane Prost
Stem cell factor-displaying simian immunodeficiency viral vectors together with a low conditioning regimen allow for long-term engraftment of gene-marked autologous hematopoietic stem cells in macaques.
Human gene therapy 2012;23(7):754-68.
2012: Emmanuel Payen; Philippe Leboulch
Advances in stem cell transplantation and gene therapy in the β-hemoglobinopathies.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2012;2012():276-83.
2012: Emmanuel Payen; Olivier Negre; Yves Beuzard; Charlotte Colomb; Kathleen Hehir; Philippe Leboulch
Lentivirus vectors in β-thalassemia.
Methods in enzymology 2012;507():109-24.
2011: Irfan Saadi; Ursela Siddiqui; Annick Turbe-Doan; Cynthia C Morton; Jeffrey C Murray; Aline L Petrin; Antonio Richieri-Costa; Fowzan S Alkuraya; Resy Cavallesco; Robert P Erickson; Stephen S Gisselbrecht; Thomas W Glover; Wolfram Goessling; Arthur W Grix; James Harris; Hanne D Hove; Philippe Leboulch; Richard L Maas
Deficiency of the cytoskeletal protein SPECC1L leads to oblique facial clefting.
American journal of human genetics 2011;89(1):44-55.
2011: Keshet Ronen; Shoshannah Roth; Yves Beuzard; Troy Brady; Charlotte Colomb; Maria Denaro; Julian D Down; Floriane Fusil; Beatrix Gillet-Legrand; Kathleen Hehir; Philippe Leboulch; Nirav Malani; Olivier Negre; Emmanuel Payen; Frederic D Bushman
Distribution of lentiviral vector integration sites in mice following therapeutic gene transfer to treat β-thalassemia.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(7):1273-86.
2011: Olivier Negre; Floriane Fusil; Charlotte Colomb; Shoshannah Roth; Beatrix Gillet-Legrand; Annie Henri; Yves Beuzard; Frederic Bushman; Philippe Leboulch; Emmanuel Payen
Correction of murine β-thalassemia after minimal lentiviral gene transfer and homeostatic in vivo erythroid expansion.
Blood 2011;117(20):5321-31.
2011: Marina Cavazzana-Calvo; Alain Fischer; Frederic D Bushman; Emmanuel Payen; Salima Hacein-Bey-Abina; Philippe Leboulch
Is normal hematopoiesis maintained solely by long-term multipotent stem cells?
Blood 2011;117(17):4420-4.
2010: Gary P Wang; Charles C Berry; Nirav Malani; Philippe Leboulch; Alain Fischer; Salima Hacein-Bey-Abina; Marina Cavazzana-Calvo; Frederic D Bushman
Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial.
Blood 2010;115(22):4356-66.
2009: Nathalie Cartier; Salima Hacein-Bey-Abina; Cynthia C Bartholomae; Gabor Veres; Manfred Schmidt; Ina Kutschera; Michel Vidaud; Ulrich Abel; Liliane Dal Cortivo; Laure Caccavelli; Nizar Mahlaoui; veronique kiermer; Denice Mittelstaedt; Céline Bellesme; Najiba Lahlou; François Lefrère; Stéphane Blanche; Muriel Audit; Emmanuel Payen; Philippe Leboulch; Bruno l'Homme; Pierre Bougnères; Christof von Kalle; Alain Fischer; Marina Cavazzana-Calvo; Patrick Aubourg
Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy.
Science (New York, N.Y.) 2009;326(5954):818-23.
2009: Zahra Kadri; Ritsuko Shimizu; Osamu Ohneda; Leila Maouche-Chretien; Sylvie Gisselbrecht; Masayuki Yamamoto; Paul-Henri Romeo; Philippe Leboulch; Stany Chretien
Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis.
PLoS biology 2009;7(6):e1000123.
2009: Arthur J Simonnet; Johnny Nehmé; Pierre Vaigot; Vilma Barroca; Philippe Leboulch; Diana Tronik-Le Roux
Phenotypic and functional changes induced in hematopoietic stem/progenitor cells after gamma-ray radiation exposure.
Stem cells (Dayton, Ohio) 2009;27(6):1400-9.
2008: Olivier Negre; Floriane Fusil; Annie Henri; Jean-Marie Villette; Philippe Leboulch; Yves Beuzard; Emmanuel Payen
Activation and inhibition of the erythropoietin receptor by a membrane-anchored erythropoietin.
Experimental hematology 2008;36(4):412-23.
2008: Emmanuel E Comoy; Cristina Casalone; Nathalie Lescoutra-Etchegaray; Gianluigi Zanusso; Sophie Freire; Dominique Marcé; Frédéric Auvré; Marie-Magdeleine Ruchoux; Sergio Ferrari; Salvatore Monaco; Nicole Salès; Maria Caramelli; Philippe Leboulch; Paul Brown; Corinne I Lasmézas; Jean-Philippe Deslys
Atypical BSE (BASE) transmitted from asymptomatic aging cattle to a primate.
PloS one 2008;3(8):e3017.
2007: Toshinori Totsugawa; Chen Yong; Jorge David Rivas-Carrillo; Alejandro Soto-Gutierrez; Nalu Navarro-Alvarez; Hirofumi Noguchi; Teru Okitsu; Karen A Westerman; Michinori Kohara; Michael Reth; Noriaki Tanaka; Philippe Leboulch; Naoya Kobayashi
Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with Tamoxifen-mediated self-recombination.
Journal of hepatology 2007;47(1):74-82.
2007: Karen A Westerman; Zhujun Ao; Eric A Cohen; Philippe Leboulch
Design of a trans protease lentiviral packaging system that produces high titer virus.
Retrovirology 2007;4():96.
2006: Hui-Ying Qiu; Yoshihiro Fujimori; Keisuke Nishioka; Nobuko Yamaguchi; Tomoko Hashimoto-Tamaoki; Ayako Sugihara; Nobuyuki Terada; Noritoshi Nagaya; Munetake Kanda; Naoya Kobayashi; Noriaki Tanaka; Karen A Westerman; Philippe Leboulch; Hiroshi Hara
Postnatal neovascularization by endothelial progenitor cells immortalized with the simian virus 40T antigen gene.
International journal of oncology 2006;28(4):815-21.
2005: Michiki Narushima; Naoya Kobayashi; Teru Okitsu; Yoshihito Tanaka; Shun-Ai Li; Yong Chen; Atsushi Miki; Kimiaki Tanaka; Shuhei Nakaji; Kohji Takei; Alejandro Soto Gutierrez; Jorge David Rivas-Carrillo; Nalu Navarro-Alvarez; Hee-Sook Jun; Karen A Westerman; Hirofumi Noguchi; Jonathan R T Lakey; Philippe Leboulch; Noriaki Tanaka; Ji-Won Yoon
A human beta-cell line for transplantation therapy to control type 1 diabetes.
Nature biotechnology 2005;23(10):1274-82.
2005: Zahra Kadri; Leila Maouche-Chretien; Heather M Rooke; Stuart H Orkin; Paul-Henri Romeo; Patrick Mayeux; Philippe Leboulch; Stany Chretien
Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation.
Molecular and cellular biology 2005;25(17):7412-22.
2005: Jia-Lin Zhang; Jin Cai; Shannon Walls; John D Jackson; Charles A Kuszynski; Yong Zhao; Robert Pawliuk; Philippe Leboulch; Ira J Fox
Tolerance by selective in vivo expansion of foreign major histocompatibility complex-transduced autologous bone marrow.
Transplantation 2005;80(3):362-9.
2005: Bruno Dalle; Joel E Rubin; Ozan Alkan; Tanya Sukonnik; Peter Pasceri; Shuyuan Yao; Robert Pawliuk; Philippe Leboulch; James Ellis
eGFP reporter genes silence LCRbeta-globin transgene expression via CpG dinucleotides.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(4):591-9.
2005: Arthur Bank; Ronald Dorazio; Philippe Leboulch
A phase I/II clinical trial of beta-globin gene therapy for beta-thalassemia.
Annals of the New York Academy of Sciences 2005;1054():308-16.
2005: Robert Pawliuk; robert Tighe; Robert J Wise; Micheline M Mathews-Roth; Philippe Leboulch
Prevention of murine erythropoietic protoporphyria-associated skin photosensitivity and liver disease by dermal and hepatic ferrochelatase.
The Journal of investigative dermatology 2005;124(1):256-62.
2004: Dominique Mahieu-Caputo; Jean-Etienne Allain; Julie Branger; Aurore Coulomb; Jean-Paul Delgado; Marion Andreoletti; Sylvie Mainot; René Frydman; Philippe Leboulch; James P Di Santo; Frédérique Capron; Anne Weber
Repopulation of athymic mouse liver by cryopreserved early human fetal hepatoblasts.
Human gene therapy 2004;15(12):1219-28.
2004: Suzan Imren; Mary E Fabry; Karen A Westerman; Robert Pawliuk; Patrick Tang; Patricia M Rosten; Ronald L Nagel; Philippe Leboulch; Connie J Eaves; R Keith Humphries
High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells.
The Journal of clinical investigation 2004;114(7):953-62.
2004: Toshihisa Matsumura; Michihiko Takesue; Karen A Westerman; Teru Okitsu; Masakiyo Sakaguchi; Takuya Fukazawa; Toshinori Totsugawa; Hirofumi Noguchi; Shinichiro Yamamoto; Donna B Stolz; Noriaki Tanaka; Philippe Leboulch; Naoya Kobayashi
Establishment of an immortalized human-liver endothelial cell line with SV40T and hTERT.
Transplantation 2004;77(9):1357-65.
2004: Il-Hoan Oh; Mary E Fabry; R Keith Humphries; Robert Pawliuk; Philippe Leboulch; Ronald Hoffman; Ronald L Nagel; Connie Eaves
Expression of an anti-sickling beta-globin in human erythroblasts derived from retrovirally transduced primitive normal and sickle cell disease hematopoietic cells.
Experimental hematology 2004;32(5):461-9.
2004: François Rivier; Ozan Alkan; Alan F Flint; Kristina R Muskiewicz; Paul D Allen; Philippe Leboulch; Emanuela Gussoni
Role of bone marrow cell trafficking in replenishing skeletal muscle SP and MP cell populations.
Journal of cell science 2004;117(Pt 10):1979-88.
2004: Daniela Geromin; Jean-François Bourge; Annie Soulié; Robert Pawliuk; Christina Fleet; Eugene Michel; Yves Denizot; Christian Berthou; Philippe Leboulch; François Sigaux; Marilyne Sasportes
Glycoprotein 170 induces platelet-activating factor receptor membrane expression and confers tumor cell hypersensitivity to NK-dependent cell lysis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3604-11.
2004: Masanobu Maruyama; Naoya Kobayashi; Karen A Westerman; Masakiyo Sakaguchi; Jean-Etienne Allain; Toshinori Totsugawa; Teru Okitsu; Takuya Fukazawa; Anne Weber; Donna B Stolz; Philippe Leboulch; Noriaki Tanaka
Establishment of a highly differentiated immortalized human cholangiocyte cell line with SV40T and hTERT.
Transplantation 2004;77(3):446-51.
2004: Teru Okitsu; Naoya Kobayashi; Hee-Sook Jun; Seungjin Shin; Su-Jin Kim; Jaeseok Han; Hyok Joon Kwon; Masakiyo Sakaguchi; Toshinori Totsugawa; Michinori Kohara; Karen A Westerman; Noriaki Tanaka; Philippe Leboulch; Ji-Won Yoon
Transplantation of reversibly immortalized insulin-secreting human hepatocytes controls diabetes in pancreatectomized pigs.
Diabetes 2004;53(1):105-12.
2003: Keisuke Nishioka; Yoshihiro Fujimori; Tomoko Hashimoto-Tamaoki; Shunro Kai; Huiying Qiu; Naoya Kobayashi; Noriaki Tanaka; Karen A Westerman; Philippe Leboulch; Hiroshi Hara
Immortalization of bone marrow-derived human mesenchymal stem cells by removable simian virus 40T antigen gene: analysis of the ability to support expansion of cord blood hematopoietic progenitor cells.
International journal of oncology 2003;23(4):925-32.
2003: Lucia De Franceschi; Antonella Baron; Aldo Scarpa; Christophe Adrie; Anne Janin; Stefano Barbi; Jean Kister; Philippe Rouyer-Fessard; Roberto Corrocher; Philippe Leboulch; Yves Beuzard
Inhaled nitric oxide protects transgenic SAD mice from sickle cell disease-specific lung injury induced by hypoxia/reoxygenation.
Blood 2003;102(3):1087-96.
2003: Takamasa Watanabe; Norikuni Shibata; Karen A Westerman; Teru Okitsu; Jean-Etienne Allain; Masakiyo Sakaguchi; Toshinori Totsugawa; Masanobu Maruyama; Toshihisa Matsumura; Hirofumi Noguchi; Shinichiro Yamamoto; Masaki Hikida; Akira Ohmori; Michael Reth; Anne Weber; Noriaki Tanaka; Philippe Leboulch; Naoya Kobayashi
Establishment of immortalized human hepatic stellate scavenger cells to develop bioartificial livers.
Transplantation 2003;75(11):1873-80.
2003: Renhai Cao; Ebba Brakenhielm; Robert Pawliuk; David Wariaro; Mark J Post; eric wahlberg; Philippe Leboulch; Yihai Cao
Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2.
Nature medicine 2003;9(5):604-13.
2003: Elvire Gouze; Robert Pawliuk; Jean-Noel Gouze; Carmencita Pilapil; Christina Fleet; Glyn D Palmer; Christopher H Evans; Philippe Leboulch; Steven C Ghivizzani
Lentiviral-mediated gene delivery to synovium: potent intra-articular expression with amplification by inflammation.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(4):460-6.
2002: Suzan Imren; Emmanuel Payen; Karen A Westerman; Robert Pawliuk; Mary E Fabry; Connie J Eaves; Benjamin Cavilla; Louis D Wadsworth; Yves Beuzard; Eric E Bouhassira; Robert Russell; Irving M London; Ronald L Nagel; Philippe Leboulch; R Keith Humphries
Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14380-5.
2002: Frank Nicolini; Suzan Imren; Il-Hoan Oh; R Keith Humphries; Philippe Leboulch; Mary E Fabry; Ronald L Nagel; Connie J Eaves
Expression of a human beta-globin transgene in erythroid cells derived from retrovirally transduced transplantable human fetal liver and cord blood cells.
Blood 2002;100(4):1257-64.
2002: Jin Cai; Masahiro Ito; Hideo Nagata; Karen A Westerman; Daryl Lafleur; Jayanta Roy-Chowdhury; Philippe Leboulch; Ira J Fox
Treatment of liver failure in rats with end-stage cirrhosis by transplantation of immortalized hepatocytes.
Hepatology (Baltimore, Md.) 2002;36(2):386-94.
2002: Elvire Gouze; Robert Pawliuk; Carmencita Pilapil; Jean-Noel Gouze; Christina Fleet; Glyn D Palmer; Christopher H Evans; Philippe Leboulch; Steven C Ghivizzani
In vivo gene delivery to synovium by lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(4):397-404.
2002: Wolfgang Eisterer; Xiaoyan Jiang; Thomas Bachelot; Robert Pawliuk; Carolina Abramovich; Philippe Leboulch; Donna E Hogge; Connie Eaves
Unfulfilled promise of endostatin in a gene therapy-xenotransplant model of human acute lymphocytic leukemia.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(4):352-9.
2002: Robert Pawliuk; Thomas Bachelot; Omar Zurkiya; Anna Eriksson; Yihai Cao; Philippe Leboulch
Continuous intravascular secretion of endostatin in mice from transduced hematopoietic stem cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(4):345-51.
2002: Jean-Etienne Allain; Ibrahim Dagher; Dominique Mahieu-Caputo; Nathalie Loux; Marion Andreoletti; Karen A Westerman; Pascale Briand; Dominique Franco; Philippe Leboulch; Anne Weber
Immortalization of a primate bipotent epithelial liver stem cell.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3639-44.
2002: Anna Eriksson; Renhai Cao; Robert Pawliuk; Sanna Maria Berg; Monica Tsang; Danielle Zhou; Christina Fleet; Katerina Tritsaris; Steen Dissing; Philippe Leboulch; Yihai Cao
Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers.
Cancer cell 2002;1(1):99-108.
2002: Hirofumi Noguchi; Naoya Kobayashi; Karen A Westerman; Masakiyo Sakaguchi; Teru Okitsu; Toshinori Totsugawa; Takamasa Watanabe; Toshihisa Matsumura; Toshiyoshi Fujiwara; Tadayoshi Ueda; Masahiro Miyazaki; Noriaki Tanaka; Philippe Leboulch
Controlled expansion of human endothelial cell populations by Cre-loxP-based reversible immortalization.
Human gene therapy 2002;13(2):321-34.
2001: Robert Pawliuk; Karen A Westerman; Mary E Fabry; Emmanuel Payen; robert Tighe; Eric E Bouhassira; Seetharama A Acharya; James Ellis; Irving M London; Connie J Eaves; R Keith Humphries; Yves Beuzard; Ronald L Nagel; Philippe Leboulch
Correction of sickle cell disease in transgenic mouse models by gene therapy.
Science (New York, N.Y.) 2001;294(5550):2368-71.
2001: An-Ping Han; C Yu; Linrong Lu; Y Fujiwara; C Browne; G Chin; M Fleming; Philippe Leboulch; Stuart H Orkin; Jane-Jane Chen
Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency.
The EMBO journal 2001;20(23):6909-18.
2001: N Kobayashi; Karen A Westerman; T Taguchi; M Sakaguchi; Toshiyoshi Fujiwara; H Urata; N Kishimoto; N Hayashi; S Nakaji; T Murakami; Philippe Leboulch; Noriaki Tanaka
Expansion of human hepatocyte populations by a retroviral gene transfer of simian virus 40 large T antigen.
ASAIO journal (American Society for Artificial Internal Organs : 1992) 2001;47(5):481-5.
2001: N Kobayashi; Masahiro Miyazaki; Karen A Westerman; H Noguchi; M Sakaguchi; Toshinori Totsugawa; T Watanabe; T Matsumura; Toshiyoshi Fujiwara; Philippe Leboulch; Noriaki Tanaka; Masayoshi Namba
Construction of a differentiated human hepatocyte cell line expressing the herpes simplex virus-thymidine kinase gene.
ASAIO journal (American Society for Artificial Internal Organs : 1992) 2001;47(5):476-80.
2001: N Kobayashi; H Noguchi; Karen A Westerman; T Watanabe; T Matsumura; Toshinori Totsugawa; Toshiyoshi Fujiwara; Philippe Leboulch; Noriaki Tanaka
Cre/loxP-based reversible immortalization of human hepatocytes.
Cell transplantation 2001;10(4-5):383-6.
2001: N Kobayashi; H Noguchi; Karen A Westerman; T Watanabe; T Matsumura; Toshinori Totsugawa; Toshiyoshi Fujiwara; Philippe Leboulch; Noriaki Tanaka
Successful retroviral gene transfer of simian virus 40 T antigen and herpes simplex virus-thymidine kinase into human hepatocytes.
Cell transplantation 2001;10(4-5):377-81.
2001: Emmanuel Jouanneau; laurent alberti; Mimoun Nejjari; Isabelle Treilleux; I Vilgrain; Adeline Duc; V Combaret; Marie-Christine Favrot; Philippe Leboulch; Thomas Bachelot
Lack of antitumor activity of recombinant endostatin in a human neuroblastoma xenograft model.
Journal of neuro-oncology 2001;51(1):11-8.
2000: N Kobayashi; H Noguchi; T Watanabe; T Matsumura; Toshinori Totsugawa; Toshiyoshi Fujiwara; T Taguchi; H Urata; N Kishimoto; N Hayashi; S Nakaji; Karen A Westerman; Philippe Leboulch; T Murakami; Noriaki Tanaka
A new approach to develop a biohybrid artificial liver using a tightly regulated human hepatocyte cell line.
Human cell 2000;13(4):229-35.
2000: N Kobayashi; H Noguchi; Toshiyoshi Fujiwara; Karen A Westerman; Philippe Leboulch; Noriaki Tanaka
Establishment of a highly differentiated immortalized adult human hepatocyte cell line by retroviral gene transfer.
Transplantation proceedings 2000;32(7):2368-9.
2000: Jin Cai; Masahiro Ito; Karen A Westerman; N Kobayashi; Philippe Leboulch; Ira J Fox
Construction of a non-tumorigenic rat hepatocyte cell line for transplantation: reversal of hepatocyte immortalization by site-specific excision of the SV40 T antigen.
Journal of hepatology 2000;33(5):701-8.
2000: J S Crosby; PJ Chefalo; I Yeh; S Ying; Irving M London; Philippe Leboulch; Jane-Jane Chen
Regulation of hemoglobin synthesis and proliferation of differentiating erythroid cells by heme-regulated eIF-2alpha kinase.
Blood 2000;96(9):3241-8.
2000: N Kobayashi; H Noguchi; Karen A Westerman; T Matsumura; T Watanabe; Toshinori Totsugawa; Toshiyoshi Fujiwara; Philippe Leboulch; Noriaki Tanaka
Efficient Cre/loxP site-specific recombination in a HepG2 human liver cell line.
Cell transplantation 2000;9(5):737-42.
2000: J E Rubin; Peter Pasceri; X Wu; Philippe Leboulch; James Ellis
Locus control region activity by 5'HS3 requires a functional interaction with beta-globin gene regulatory elements: expression of novel beta/gamma-globin hybrid transgenes.
Blood 2000;95(10):3242-9.
2000: Christian Kalberer; Robert Pawliuk; Suzan Imren; Thomas Bachelot; K J Takekoshi; Mary E Fabry; Connie J Eaves; Irving M London; R Keith Humphries; Philippe Leboulch
Preselection of retrovirally transduced bone marrow avoids subsequent stem cell gene silencing and age-dependent extinction of expression of human beta-globin in engrafted mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5411-5.
2000: N Kobayashi; H Noguchi; T Watanabe; T Matsumura; Toshinori Totsugawa; Toshiyoshi Fujiwara; Karen A Westerman; Philippe Leboulch; Ira J Fox; Noriaki Tanaka
Establishment of a tightly regulated human cell line for the development of hepatocyte transplantation.
Human cell 2000;13(1):7-13.
2000: N Kobayashi; T Fujiwara; Karen A Westerman; Y Inoue; M Sakaguchi; H Noguchi; M Miyazaki; J Cai; N Tanaka; Ira J Fox; Philippe Leboulch
Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes.
Science (New York, N.Y.) 2000;287(5456):1258-62.
1999: Yong-Qing Feng; Jost Seibler; Raouf Alami; A Eisen; Karen A Westerman; Philippe Leboulch; Steven Fiering; Eric E Bouhassira
Site-specific chromosomal integration in mammalian cells: highly efficient CRE recombinase-mediated cassette exchange.
Journal of molecular biology 1999;292(4):779-85.
1999: C C Lai; Peter Gouras; Kentaro Doi; F Lu; Hild Kjeldbye; Stephen P Goff; Robert Pawliuk; Philippe Leboulch; Stephen H Tsang
Tracking RPE transplants labeled by retroviral gene transfer with green fluorescent protein.
Investigative ophthalmology & visual science 1999;40(9):2141-6.
1999: Robert Pawliuk; Thomas Bachelot; R J Wise; Micheline M Mathews-Roth; Philippe Leboulch
Long-term cure of the photosensitivity of murine erythropoietic protoporphyria by preselective gene therapy.
Nature medicine 1999;5(7):768-73.
1999: B Hennemann; Eibhlin Conneally; Robert Pawliuk; Philippe Leboulch; S Rose-John; D Reid; Jean Y Chuo; R Keith Humphries; Connie J Eaves
Optimization of retroviral-mediated gene transfer to human NOD/SCID mouse repopulating cord blood cells through a systematic analysis of protocol variables.
Experimental hematology 1999;27(5):817-25.
1998: Robert Pawliuk; Thomas Bachelot; Harry Raftopoulos; Christian Kalberer; R Keith Humphries; Arthur Bank; Philippe Leboulch
Retroviral vectors aimed at the gene therapy of human beta-globin gene disorders.
Annals of the New York Academy of Sciences 1998;850():151-62.
1997: Harry Raftopoulos; Maureen Ward; Philippe Leboulch; Arthur Bank
Long-term transfer and expression of the human beta-globin gene in a mouse transplant model.
Blood 1997;90(9):3414-22.
1997: Eric E Bouhassira; Karen A Westerman; Philippe Leboulch
Transcriptional behavior of LCR enhancer elements integrated at the same chromosomal locus by recombinase-mediated cassette exchange.
Blood 1997;90(9):3332-44.
1997: Keyun Qing; Thomas Bachelot; P Mukherjee; XS Wang; L Peng; Mervin C Yoder; Philippe Leboulch; Arun Srivastava
Adeno-associated virus type 2-mediated transfer of ecotropic retrovirus receptor cDNA allows ecotropic retroviral transduction of established and primary human cells.
Journal of virology 1997;71(7):5663-7.
1996: K A Westerman; Philippe Leboulch
Reversible immortalization of mammalian cells mediated by retroviral transfer and site-specific recombination.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):8971-6.
1995: Igor B Rosenwald; R Kaspar; D Rousseau; Lee Gehrke; Philippe Leboulch; J J Chen; Emmett V Schmidt; Nahum Sonenberg; I M London
Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels.
The Journal of biological chemistry 1995;270(36):21176-80.
1995: K J Takekoshi; Y H Oh; K W Westerman; I M London; Philippe Leboulch
Retroviral transfer of a human beta-globin/delta-globin hybrid gene linked to beta locus control region hypersensitive site 2 aimed at the gene therapy of sickle cell disease.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):3014-8.
1994: Philippe Leboulch; G M Huang; R Keith Humphries; Y H Oh; C J Eaves; D Y Tuan; I M London
Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure.
The EMBO journal 1994;13(13):3065-76.