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Dafna Bar-Sagi
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10
Kuriyan, John
8
Sondermann, Holger
7
Joneson, T
7
Nimnual, Anjaruwee
6
Archer, Herbert
5
Jura, Natalia
5
Schlessinger, Joseph
5
Taylor, Laura
4
Van Aelst, Linda
4
Corbalan-Garcia, Senena
4
Greenberger, Joel
4
Boykevisch, Sean
4
Epperly, Michael
4
Hall, Brian
3
Gretton, Joan
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All Publications
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2009: Connolly Michael K; Bedrosian Andrea S; Mallen-St Clair Jon; Mitchell Aaron P; Ibrahim Junaid; Stroud Andrea; Pachter H Leon; Bar-Sagi Dafna; Frey Alan B; Miller George
In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha.
The Journal of clinical investigation 2009;119(11):3213-25.
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2009: Grabocka Elda; Bar-Sagi Dafna
Raf-1 and squamous cell carcinoma: Rok-ing the boat.
Cancer cell 2009;16(2):85-6.
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2009: Fehrenbacher Nicole; Bar-Sagi Dafna; Philips Mark
Ras/MAPK signaling from endomembranes.
Molecular oncology 2009;3(4):297-307.
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2009: Frank Matthew J; Dawson David W; Bensinger Steven J; Hong Jason S; Knosp Wendy M; Xu Lizhong; Balatoni Cynthia E; Allen Eric L; Shen Rhine R; Bar-Sagi Dafna; Martin Gail R; Teitell Michael A
Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas.
Blood 2009;113(11):2478-87.
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2008: Qi Jianfei; Nakayama Koh; Gaitonde Supriya; Goydos James S; Krajewski Stan; Eroshkin Alexey; Bar-Sagi Dafna; Bowtell David; Ronai Ze'ev
The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(43):16713-8.
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2008: Garcia Avalon; Zheng Yang; Zhao Chen; Toschi Alfredo; Fan Judy; Shraibman Natalie; Brown H Alex; Bar-Sagi Dafna; Foster David A; Arbiser Jack L
Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(13):4267-74.
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2008: Ojima Iwao; Chen Jin; Sun Liang; Borella Christopher P; Wang Tao; Miller Michael L; Lin Songnian; Geng Xudong; Kuznetsova Larisa; Qu Chuanxing; Gallager David; Zhao Xianrui; Zanardi Ilaria; Xia Shujun; Horwitz Susan B; Mallen-St Clair Jon; Guerriero Jennifer L; Bar-Sagi Dafna; Veith Jean M; Pera Paula; Bernacki Ralph J
Design, synthesis, and biological evaluation of new-generation taxoids.
Journal of medicinal chemistry 2008;51(11):3203-21.
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2008: Gureasko Jodi; Galush William J; Boykevisch Sean; Sondermann Holger; Bar-Sagi Dafna; Groves Jay T; Kuriyan John
Membrane-dependent signal integration by the Ras activator Son of sevenless.
Nature structural & molecular biology 2008;15(5):452-61.
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2008: Terrillon Sonia; Bar-Sagi Dafna
Biochemical and biophysical analyses of Ras modification by ubiquitin.
Methods in enzymology 2008;438():259-76.
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2007: Zhao Chen; Du Guangwei; Skowronek Karl; Frohman Michael A; Bar-Sagi Dafna
Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos.
Nature cell biology 2007;9(6):706-12.
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2007: Yeh Brian J; Rutigliano Robert J; Deb Anrica; Bar-Sagi Dafna; Lim Wendell A
Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors.
Nature 2007;447(7144):596-600.
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2007: Kim Hong Joo; Taylor Laura J; Bar-Sagi Dafna
Spatial regulation of EGFR signaling by Sprouty2.
Current biology : CB 2007;17(5):455-61.
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2007: Tartaglia Marco; Pennacchio Len A; Zhao Chen; Yadav Kamlesh K; Fodale Valentina; Sarkozy Anna; Pandit Bhaswati; Oishi Kimihiko; Martinelli Simone; Schackwitz Wendy; Ustaszewska Anna; Martin Joel; Bristow James; Carta Claudio; Lepri Francesca; Neri Cinzia; Vasta Isabella; Gibson Kate; Curry Cynthia J; Siguero Juan Pedro López; Digilio Maria Cristina; Zampino Giuseppe; Dallapiccola Bruno; Bar-Sagi Dafna; Gelb Bruce D
Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome.
Nature genetics 2007;39(1):75-9.
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2006: Jura Natalia; Bar-Sagi Dafna
Mapping cellular routes of Ras: a ubiquitin trail.
Cell cycle (Georgetown, Tex.) 2006;5(23):2744-7.
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2006: Archer Herbert; Jura Natalia; Keller James; Jacobson Matthew; Bar-Sagi Dafna
A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen.
Gastroenterology 2006;131(6):1844-55.
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2006: Boykevisch Sean; Zhao Chen; Sondermann Holger; Philippidou Polyxeni; Halegoua Simon; Kuriyan John; Bar-Sagi Dafna
Regulation of ras signaling dynamics by Sos-mediated positive feedback.
Current biology : CB 2006;16(21):2173-9.
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2006: Freedman Tanya S; Sondermann Holger; Friedland Gregory D; Kortemme Tanja; Bar-Sagi Dafna; Marqusee Susan; Kuriyan John
A Ras-induced conformational switch in the Ras activator Son of sevenless.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16692-7.
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2006: Nikolic Djordje L; Boettiger Alistair N; Bar-Sagi Dafna; Carbeck Jeffrey D; Shvartsman Stanislav Y
Role of boundary conditions in an experimental model of epithelial wound healing.
American journal of physiology. Cell physiology 2006;291(1):C68-75.
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2006: Jura Natalia; Scotto-Lavino Elizabeth; Sobczyk Aleksander; Bar-Sagi Dafna
Differential modification of Ras proteins by ubiquitination.
Molecular cell 2006;21(5):679-87.
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2006: DaSilva John; Xu Lizhong; Kim Hong Joo; Miller W Todd; Bar-Sagi Dafna
Regulation of sprouty stability by Mnk1-dependent phosphorylation.
Molecular and cellular biology 2006;26(5):1898-907.
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2006: Agbunag Cristina; Lee Kyoung Eun; Buontempo Serena; Bar-Sagi Dafna
Pancreatic duct epithelial cell isolation and cultivation in two-dimensional and three-dimensional culture systems.
Methods in enzymology 2006;407():703-10.
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2005: Sondermann Holger; Nagar Bhushan; Bar-Sagi Dafna; Kuriyan John
Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(46):16632-7.
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2005: Sondermann Holger; Zhao Chen; Bar-Sagi Dafna
Analysis of Ras:RasGEF interactions by phage display and static multi-angle light scattering.
Methods (San Diego, Calif.) 2005;37(2):197-202.
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2005: Ford Bradley; Skowronek Karlheinz; Boykevisch Sean; Bar-Sagi Dafna; Nassar Nicolas
Structure of the G60A mutant of Ras: implications for the dominant negative effect.
The Journal of biological chemistry 2005;280(27):25697-705.
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2005: Sparmann Anke; Bar-Sagi Dafna
Ras oncogene and inflammation: partners in crime.
Cell cycle (Georgetown, Tex.) 2005;4(6):735-6.
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2005: Jura Natalia; Archer Herbert; Bar-Sagi Dafna
Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between.
Cell research 2005;15(1):72-7.
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2004: Sparmann Anke; Bar-Sagi Dafna
Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis.
Cancer cell 2004;6(5):447-58.
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2004: Sondermann Holger; Soisson Stephen M; Boykevisch Sean; Yang Shao-Song; Bar-Sagi Dafna; Kuriyan John
Structural analysis of autoinhibition in the Ras activator Son of sevenless.
Cell 2004;119(3):393-405.
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2004: Agbunag Cristina; Bar-Sagi Dafna
Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells.
Cancer research 2004;64(16):5659-63.
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2004: Kim Hong Joo; Bar-Sagi Dafna
Modulation of signalling by Sprouty: a developing story.
Nature reviews. Molecular cell biology 2004;5(6):441-50.
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2003: Sondermann Holger; Soisson Stephen M; Bar-Sagi Dafna; Kuriyan John
Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless.
Structure (London, England : 1993) 2003;11(12):1583-93.
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2003: Kennedy Norman J; Sluss Hayla K; Jones Stephen N; Bar-Sagi Dafna; Flavell Richard A; Davis Roger J
Suppression of Ras-stimulated transformation by the JNK signal transduction pathway.
Genes & development 2003;17(5):629-37.
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2003: Margarit S Mariana; Sondermann Holger; Hall Brian E; Nagar Bhushan; Hoelz Andre; Pirruccello Michelle; Bar-Sagi Dafna; Kuriyan John
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS.
Cell 2003;112(5):685-95.
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2003: Guo Hongliang; Seixas-Silva Jose A; Epperly Michael W; Gretton Joan E; Shin Dong M; Bar-Sagi Dafna; Archer Herbert; Greenberger Joel S
Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene.
Radiation research 2003;159(3):361-70.
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2003: Nimnual Anjaruwee S; Taylor Laura J; Bar-Sagi Dafna
Redox-dependent downregulation of Rho by Rac.
Nature cell biology 2003;5(3):236-41.
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2003: Hall Amy B; Jura Natalia; DaSilva John; Jang Yeon Joo; Gong Delquin; Bar-Sagi Dafna
hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl.
Current biology : CB 2003;13(4):308-14.
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2003: Epperly M W; Guo H L; Jefferson M; Nie S; Gretton J; Bernarding M; Bar-Sagi D; Archer H; Greenberger J S
Cell phenotype specific kinetics of expression of intratracheally injected manganese superoxide dismutase-plasmid/liposomes (MnSOD-PL) during lung radioprotective gene therapy.
Gene therapy 2003;10(2):163-71.
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2002: Nahle Zaher; Polakoff Julia; Davuluri Ramana V; McCurrach Mila E; Jacobson Matthew D; Narita Masashi; Zhang Michael Q; Lazebnik Yuri; Bar-Sagi Dafna; Lowe Scott W
Direct coupling of the cell cycle and cell death machinery by E2F.
Nature cell biology 2002;4(11):859-64.
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2002: Farhang-Fallah Janet; Randhawa Varinder K; Nimnual Anjaruwee; Klip Amira; Bar-Sagi Dafna; Rozakis-Adcock Maria
The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation.
Molecular and cellular biology 2002;22(20):7325-36.
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2002: Hall Brian E; Bar-Sagi Dafna; Nassar Nicolas
The structural basis for the transition from Ras-GTP to Ras-GDP.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12138-42.
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2002: Nimnual Anjaruwee; Bar-Sagi Dafna
The two hats of SOS.
Science's STKE : signal transduction knowledge environment 2002;2002(145):pe36.
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2002: Lei Kui; Nimnual Anjaruwee; Zong Wei-Xing; Kennedy Norman J; Flavell Richard A; Thompson Craig B; Bar-Sagi Dafna; Davis Roger J
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase.
Molecular and cellular biology 2002;22(13):4929-42.
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2002: Egan James E; Hall Amy B; Yatsula Bogdan A; Bar-Sagi Dafna
The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6041-6.
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2002: Hall Brian E; Yang Shao-Song; Bar-Sagi Dafna
Autoinhibition of Sos by intramolecular interactions.
Frontiers in bioscience : a journal and virtual library 2002;7():d288-94.
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2002: Archer Herbert; Bar-Sagi Dafna
Ras and Rac as activators of reactive oxygen species (ROS).
Methods in molecular biology (Clifton, N.J.) 2002;189():67-73.
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2002: Epperly Michael W; Sikora Christine A; DeFilippi Stacy J; Gretton Joan E; Bar-Sagi Dafna; Archer Herbert; Carlos Timothy; Guo HongLiang; Greenberger Joel S
Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2002;8(4):175-87.
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2001: Epperly M W; Kagan V E; Sikora C A; Gretton J E; Defilippi S J; Bar-Sagi D; Greenberger J S
Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation.
International journal of cancer. Journal international du cancer 2001;96(4):221-31.
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2001: Hall B E; Yang S S; Boriack-Sjodin P A; Kuriyan J; Bar-Sagi D
Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange.
The Journal of biological chemistry 2001;276(29):27629-37.
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2001: Walsh A B; Bar-Sagi D
Differential activation of the Rac pathway by Ha-Ras and K-Ras.
The Journal of biological chemistry 2001;276(19):15609-15.
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2001: Bar-Sagi D
A Ras by any other name.
Molecular and cellular biology 2001;21(5):1441-3.
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2000: Bar-Sagi D; Hall A
Ras and Rho GTPases: a family reunion.
Cell 2000;103(2):227-38.
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2000: Tournier C; Hess P; Yang D D; Xu J; Turner T K; Nimnual A; Bar-Sagi D; Jones S N; Flavell R A; Davis R J
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway.
Science (New York, N.Y.) 2000;288(5467):870-4.
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2000: Schaley J; O'Connor R J; Taylor L J; Bar-Sagi D; Hearing P
Induction of the cellular E2F-1 promoter by the adenovirus E4-6/7 protein.
Journal of virology 2000;74(5):2084-93.
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2000: Taylor L J; Walsh A B; Hearing P; Bar-Sagi D
Single cell assays for Rac activity.
Methods in enzymology 2000;325():327-34.
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1999: Joneson T; Bar-Sagi D
Suppression of Ras-induced apoptosis by the Rac GTPase.
Molecular and cellular biology 1999;19(9):5892-901.
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1999: Weber J D; Taylor L J; Roussel M F; Sherr C J; Bar-Sagi D
Nucleolar Arf sequesters Mdm2 and activates p53.
Nature cell biology 1999;1(1):20-6.
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1999: Kumar C C; Ohashi K; Nagata K; Walsh A; Bar-Sagi D; Mizuno K
SCH 51344, an inhibitor of RAS/RAC-mediated cell morphology pathway.
Annals of the New York Academy of Sciences 1999;886():122-31.
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1998: Soisson S M; Nimnual A S; Uy M; Bar-Sagi D; Kuriyan J
Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.
Cell 1998;95(2):259-68.
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1998: Boriack-Sjodin P A; Margarit S M; Bar-Sagi D; Kuriyan J
The structural basis of the activation of Ras by Sos.
Nature 1998;394(6691):337-43.
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1998: Joneson T; Bar-Sagi D
A Rac1 effector site controlling mitogenesis through superoxide production.
The Journal of biological chemistry 1998;273(29):17991-4.
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1998: Joneson T; Fulton J A; Volle D J; Chaika O V; Bar-Sagi D; Lewis R E
Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors.
The Journal of biological chemistry 1998;273(13):7743-8.
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1998: Corbalan-Garcia S; Margarit S M; Galron D; Yang S S; Bar-Sagi D
Regulation of Sos activity by intramolecular interactions.
Molecular and cellular biology 1998;18(2):880-6.
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1998: Nimnual A S; Yatsula B A; Bar-Sagi D
Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.
Science (New York, N.Y.) 1998;279(5350):560-3.
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1997: Walsh A B; Dhanasekaran M; Bar-Sagi D; Kumar C C
SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway.
Oncogene 1997;15(21):2553-60.
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1997: Zheng J; Chen R H; Corblan-Garcia S; Cahill S M; Bar-Sagi D; Cowburn D
The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains.
The Journal of biological chemistry 1997;272(48):30340-4.
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1997: Joneson T; Bar-Sagi D
Ras effectors and their role in mitogenesis and oncogenesis.
Journal of molecular medicine (Berlin, Germany) 1997;75(8):587-93.
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1997: Chen R H; Corbalan-Garcia S; Bar-Sagi D
The role of the PH domain in the signal-dependent membrane targeting of Sos.
The EMBO journal 1997;16(6):1351-9.
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1996: Joneson T; McDonough M; Bar-Sagi D; Van Aelst L
RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase.
Science (New York, N.Y.) 1996;274(5291):1374-6.
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1996: Corbalan-Garcia S; Yang S S; Degenhardt K R; Bar-Sagi D
Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2.
Molecular and cellular biology 1996;16(10):5674-82.
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1996: Van Aelst L; Joneson T; Bar-Sagi D
Identification of a novel Rac1-interacting protein involved in membrane ruffling.
The EMBO journal 1996;15(15):3778-86.
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1996: Corbalan-Garcia S; Degenhardt K R; Bar-Sagi D
Insulin-induced dissociation of Sos from Grb2 does not contribute to the down regulation of Ras activation.
Oncogene 1996;12(5):1063-8.
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1996: Joneson T; White M A; Wigler M H; Bar-Sagi D
Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.
Science (New York, N.Y.) 1996;271(5250):810-2.
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1995: Yang S S; Van Aelst L; Bar-Sagi D
Differential interactions of human Sos1 and Sos2 with Grb2.
The Journal of biological chemistry 1995;270(31):18212-5.
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1995: Bar-Sagi D
Mammalian cell microinjection assay.
Methods in enzymology 1995;255():436-42.
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1995: Frech M; Cussac D; Chardin P; Bar-Sagi D
Purification of baculovirus-expressed human Sos1 protein.
Methods in enzymology 1995;255():125-9.
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1994: Rotin D; Bar-Sagi D; O'Brodovich H; Merilainen J; Lehto V P; Canessa C M; Rossier B C; Downey G P
An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane.
The EMBO journal 1994;13(19):4440-50.
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1994: Boyer M J; Gutmann D H; Collins F S; Bar-Sagi D
Crosslinking of the surface immunoglobulin receptor in B lymphocytes induces a redistribution of neurofibromin but not p120-GAP.
Oncogene 1994;9(2):349-57.
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1994: Schlessinger J; Bar-Sagi D
Activation of Ras and other signaling pathways by receptor tyrosine kinases.
Cold Spring Harbor symposia on quantitative biology 1994;59():173-9.
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1993: Hide I; Bennett J P; Pizzey A; Boonen G; Bar-Sagi D; Gomperts B D; Tatham P E
Degranulation of individual mast cells in response to Ca2+ and guanine nucleotides: an all-or-none event.
The Journal of cell biology 1993;123(3):585-93.
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1993: Bar-Sagi D; Rotin D; Batzer A; Mandiyan V; Schlessinger J
SH3 domains direct cellular localization of signaling molecules.
Cell 1993;74(1):83-91.
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1993: Chardin P; Camonis J H; Gale N W; van Aelst L; Schlessinger J; Wigler M H; Bar-Sagi D
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.
Science (New York, N.Y.) 1993;260(5112):1338-43.
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1993: Li N; Batzer A; Daly R; Yajnik V; Skolnik E; Chardin P; Bar-Sagi D; Margolis B; Schlessinger J
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.
Nature 1993;363(6424):85-8.
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1993: Gale N W; Kaplan S; Lowenstein E J; Schlessinger J; Bar-Sagi D
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras.
Nature 1993;363(6424):88-92.
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1992: Lowenstein E J; Daly R J; Batzer A G; Li W; Margolis B; Lammers R; Ullrich A; Skolnik E Y; Bar-Sagi D; Schlessinger J
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
Cell 1992;70(3):431-42.
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1991: Kaplan S; Bar-Sagi D
Association of p21ras with cellular polypeptides.
The Journal of biological chemistry 1991;266(28):18934-41.
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1991: Graziadei L; Burfeind P; Bar-Sagi D
Introduction of unlabeled proteins into living cells by electroporation and isolation of viable protein-loaded cells using dextran-fluorescein isothiocyanate as a marker for protein uptake.
Analytical biochemistry 1991;194(1):198-203.
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1990: Graziadei L; Riabowol K; Bar-Sagi D
Co-capping of ras proteins with surface immunoglobulins in B lymphocytes.
Nature 1990;347(6291):396-400.
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1990: Cockcroft S; Bar-Sagi D
Effect of H-ras proteins on the activity of polyphosphoinositide phospholipase C in HL60 membranes.
Cellular signalling 1990;2(3):227-34.
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1989: Bar-Sagi D
ras proteins: biological effects and biochemical targets (review).
Anticancer research 1989;9(5):1427-37.
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1989: Kim D; Lewis D L; Graziadei L; Neer E J; Bar-Sagi D; Clapham D E
G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2.
Nature 1989;337(6207):557-60.
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1988: Bar-Sagi D; Gomperts B D
Stimulation of exocytotic degranulation by microinjection of the ras oncogene protein into rat mast cells.
Oncogene 1988;3(4):463-9.
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1988: Bar-Sagi D; Suhan J P; McCormick F; Feramisco J R
Localization of phospholipase A2 in normal and ras-transformed cells.
The Journal of cell biology 1988;106(5):1649-58.
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1987: Bar-Sagi D; Fernandez A; Feramisco J R
Regulation of membrane turnover by ras proteins.
Bioscience reports 1987;7(5):427-34.
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1987: Bar-Sagi D; McCormick F; Milley R J; Feramisco J R
Inhibition of cell surface ruffling and fluid-phase pinocytosis by microinjection of anti-ras antibodies into living cells.
Journal of cellular physiology. Supplement 1987;Suppl 5():69-73.
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