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Dafna Bar-Sagi

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Chemicals & Drugs

Physiology

Signal Transduction

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Yuliya Pylayeva-Gupta; Kyoung Eun Lee; Dafna Bar-Sagi
Microdissection and culture of murine pancreatic ductal epithelial cells.
Ze-Yi Zheng; Lizhong Xu; Dafna Bar-Sagi; Eric C Chang
Escorting Ras.
Atsuo Ochi; Yuliya Pylayeva-Gupta; Adeel Rehman; Constantinos P Zambirinis; Saman Zarbakhsh; Harry M Mushlin; Andrew H Nguyen; Sana Badar; Rocky Barilla; Dafna Bar-Sagi; Andrea S Bedrosian; Nina C Fallon; Alan B Frey; Cristina H Hajdu; George Miller
MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells.

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2013: Yuliya Pylayeva-Gupta; Kyoung Eun Lee; Dafna Bar-Sagi
Microdissection and culture of murine pancreatic ductal epithelial cells.
Methods in molecular biology (Clifton, N.J.) 2013;980():267-79.
2012: Ze-Yi Zheng; Lizhong Xu; Dafna Bar-Sagi; Eric C Chang
Escorting Ras.
Small GTPases 2012;3(4):236-9.
2012: Atsuo Ochi; Yuliya Pylayeva-Gupta; Adeel Rehman; Constantinos P Zambirinis; Saman Zarbakhsh; Harry M Mushlin; Andrew H Nguyen; Sana Badar; Rocky Barilla; Dafna Bar-Sagi; Andrea S Bedrosian; Nina C Fallon; Alan B Frey; Cristina H Hajdu; George Miller
MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells.
The Journal of experimental medicine 2012;209(9):1671-87.
2012: Ying Cao; Shamit K Dutta; Guangqi E; Krishnendu Pal; Enfeng Wang; Dafna Bar-Sagi; Debabrata Mukhopadhyay
VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression.
Cancer research 2012;72(16):3912-8.
2012: Moon Hee Yang; Dafna Bar-Sagi; Marcia Haigis; Eric T Kim; Gaelle Laurent; Caroline Liot; Seth Nickerson; Mark R Philips; Yibing Shan; David E Shaw; Robert Spang; Kevin Haigis
Regulation of RAS oncogenicity by acetylation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(27):10843-8.
2012: Yuliya Pylayeva-Gupta; Cristina H Hajdu; Kyoung Eun Lee; George Miller; Dafna Bar-Sagi
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia.
Cancer cell 2012;21(6):836-47.
2012: Jon Mallen-St Clair; Raphael Margueron; George Miller; Yuliya Pylayeva-Gupta; Danny Reinberg; Rengin Soydaner-Azeloglu; Laura Taylor; Kyoung Eun Lee; Alexandra Livanos; Dafna Bar-Sagi
EZH2 couples pancreatic regeneration to neoplastic progression.
Genes & development 2012;26(5):439-44.
2012: Hao-Hsuan Jeng; Laura J Taylor; Dafna Bar-Sagi
Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis.
Nature communications 2012;3():1168.
2011: Yuliya Pylayeva-Gupta; Elda Grabocka; Dafna Bar-Sagi
RAS oncogenes: weaving a tumorigenic web.
Nature reviews. Cancer 2011;11(11):761-74.
2011: Anupam Patgiri; Kamlesh K Yadav; Paramjit S Arora; Dafna Bar-Sagi
An orthosteric inhibitor of the Ras-Sos interaction.
Nature chemical biology 2011;7(9):585-7.
2011: Fubao Lin; Xiang-Dong Ren; Zhi Pan; Lauren Macri; Wei-Xing Zong; Marcia G Tonnesen; Miriam Rafailovich; Dafna Bar-Sagi; Richard A F Clark
Fibronectin growth factor-binding domains are required for fibroblast survival.
The Journal of investigative dermatology 2011;131(1):84-98.
2010: Lizhong Xu; Jun Liang Zhou; Michael Cohen; Dafna Bar-Sagi; Kepal N Patel
Spry2 expression correlates with BRAF mutation in thyroid cancer.
Surgery 2010;148(6):1282-7; discussion 1287.
2010: Kyoung Eun Lee; Dafna Bar-Sagi
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells.
Cancer cell 2010;18(5):448-58.
2010: Lizhong Xu; Veronica Lubkov; Laura J Taylor; Dafna Bar-Sagi
Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination.
Current biology : CB 2010;20(15):1372-7.
2010: Marta Miaczynska; Dafna Bar-Sagi
Signaling endosomes: seeing is believing.
Current opinion in cell biology 2010;22(4):535-40.
2010: Michael K Connolly; Jon Mallen-St Clair; Andrea S Bedrosian; Ashim Malhotra; Valery Vera; Junaid Ibrahim; Justin Henning; H Leon Pachter; Dafna Bar-Sagi; Alan B Frey; George Miller
Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor.
Journal of leukocyte biology 2010;87(4):713-25.
2010: Kamlesh K Yadav; Dafna Bar-Sagi
Allosteric gating of Son of sevenless activity by the histone domain.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(8):3436-40.
2010: Jodi Gureasko; Olga Kuchment; Debora Lika Makino; Holger Sondermann; Dafna Bar-Sagi; John Kuriyan
Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(8):3430-5.
2009: Bradley Ford; Sean Boykevisch; Chen Zhao; Simone Kunzelmann; Dafna Bar-Sagi; Christian Herrmann; Nicolas Nassar
Characterization of a Ras mutant with identical GDP- and GTP-bound structures .
Biochemistry 2009;48(48):11449-57.
2009: Michael K Connolly; Andrea S Bedrosian; Jon Mallen-St Clair; Aaron P Mitchell; Junaid Ibrahim; Andrea Stroud; H Leon Pachter; Dafna Bar-Sagi; Alan B Frey; George Miller
In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha.
The Journal of clinical investigation 2009;119(11):3213-25.
2009: Elda Grabocka; Dafna Bar-Sagi
Raf-1 and squamous cell carcinoma: Rok-ing the boat.
Cancer cell 2009;16(2):85-6.
2009: Nicole Fehrenbacher; Dafna Bar-Sagi; Mark Philips
Ras/MAPK signaling from endomembranes.
Molecular oncology 2009;3(4):297-307.
2009: Matthew J Frank; David W Dawson; Steven J Bensinger; Jason S Hong; Wendy M Knosp; Lizhong Xu; Cynthia E Balatoni; Eric L Allen; Rhine R Shen; Dafna Bar-Sagi; Gail R Martin; Michael A Teitell
Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas.
Blood 2009;113(11):2478-87.
2008: Jianfei Qi; Koh Nakayama; Supriya Gaitonde; James S Goydos; Stan Krajewski; Alexey Eroshkin; Dafna Bar-Sagi; David Bowtell; Ze'ev Ronai
The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(43):16713-8.
2008: Avalon Garcia; Yang Zheng; Chen Zhao; Alfredo Toschi; Judy Fan; Natalie Shraibman; H Alex Brown; Dafna Bar-Sagi; David A Foster; Jack L Arbiser
Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(13):4267-74.
2008: Iwao Ojima; Jin Chen; Liang Sun; Christopher P Borella; Tao Wang; Michael L Miller; Songnian Lin; Xudong Geng; Larisa Kuznetsova; Chuanxing Qu; David Gallager; Xianrui Zhao; Ilaria Zanardi; Shujun Xia; Susan B. Horwitz; Jon Mallen-St Clair; Jennifer Lynn Guerriero; Dafna Bar-Sagi; Jean M Veith; Paula Pera; Ralph J Bernacki
Design, synthesis, and biological evaluation of new-generation taxoids.
Journal of medicinal chemistry 2008;51(11):3203-21.
2008: Jodi Gureasko; William J Galush; Sean Boykevisch; Holger Sondermann; Dafna Bar-Sagi; Jay T Groves; John Kuriyan
Membrane-dependent signal integration by the Ras activator Son of sevenless.
Nature structural & molecular biology 2008;15(5):452-61.
2008: Sonia Terrillon; Dafna Bar-Sagi
Biochemical and biophysical analyses of Ras modification by ubiquitin.
Methods in enzymology 2008;438():259-76.
2007: Chen Zhao; Guangwei Du; Karlheinz Skowronek; Michael A Frohman; Dafna Bar-Sagi
Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos.
Nature cell biology 2007;9(6):706-12.
2007: Brian J Yeh; Robert J Rutigliano; Anrica Deb; Dafna Bar-Sagi; Wendell A Lim
Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors.
Nature 2007;447(7144):596-600.
2007: Hong Joo Kim; Laura J Taylor; Dafna Bar-Sagi
Spatial regulation of EGFR signaling by Sprouty2.
Current biology : CB 2007;17(5):455-61.
2007: Marco Tartaglia; Len A Pennacchio; Chen Zhao; Kamlesh K Yadav; Valentina Fodale; Anna Sarkozy; Bhaswati Pandit; Kimihiko Oishi; Simone Martinelli; Wendy Schackwitz; Anna Ustaszewska; Joel Martin; James Bristow; Claudio Carta; Francesca Lepri; Cinzia Neri; Isabella Vasta; Kate Gibson; Cynthia J R Curry; Juan Pedro López Siguero; Maria Cristina Digilio; Giuseppe Zampino; Bruno Dallapiccola; Dafna Bar-Sagi; Bruce D Gelb
Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome.
Nature genetics 2007;39(1):75-9.
2006: Natalia Jura; Dafna Bar-Sagi
Mapping cellular routes of Ras: a ubiquitin trail.
Cell cycle (Georgetown, Tex.) 2006;5(23):2744-7.
2006: Herbert Archer; Natalia Jura; James Keller; Matthew Jacobson; Dafna Bar-Sagi
A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen.
Gastroenterology 2006;131(6):1844-55.
2006: Sean Boykevisch; Chen Zhao; Holger Sondermann; Polyxeni Philippidou; Simon Halegoua; John Kuriyan; Dafna Bar-Sagi
Regulation of ras signaling dynamics by Sos-mediated positive feedback.
Current biology : CB 2006;16(21):2173-9.
2006: Tanya S Freedman; Holger Sondermann; Gregory D Friedland; Tanja Kortemme; Dafna Bar-Sagi; Susan Marqusee; John Kuriyan
A Ras-induced conformational switch in the Ras activator Son of sevenless.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16692-7.
2006: Djordje L Nikolić; Alistair N Boettiger; Dafna Bar-Sagi; Jeffrey D Carbeck; Stanislav Y Shvartsman
Role of boundary conditions in an experimental model of epithelial wound healing.
American journal of physiology. Cell physiology 2006;291(1):C68-75.
2006: Natalia Jura; Elizabeth Scotto-Lavino; Aleksander Sobczyk; Dafna Bar-Sagi
Differential modification of Ras proteins by ubiquitination.
Molecular cell 2006;21(5):679-87.
2006: John DaSilva; Lizhong Xu; Hong Joo Kim; W Todd Miller; Dafna Bar-Sagi
Regulation of sprouty stability by Mnk1-dependent phosphorylation.
Molecular and cellular biology 2006;26(5):1898-907.
2006: Cristina Agbunag; Kyoung Eun Lee; Serena Buontempo; Dafna Bar-Sagi
Pancreatic duct epithelial cell isolation and cultivation in two-dimensional and three-dimensional culture systems.
Methods in enzymology 2006;407():703-10.
2005: Holger Sondermann; Bhushan Nagar; Dafna Bar-Sagi; John Kuriyan
Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(46):16632-7.
2005: Holger Sondermann; Chen Zhao; Dafna Bar-Sagi
Analysis of Ras:RasGEF interactions by phage display and static multi-angle light scattering.
Methods (San Diego, Calif.) 2005;37(2):197-202.
2005: Bradley Ford; Karlheinz Skowronek; Sean Boykevisch; Dafna Bar-Sagi; Nicolas Nassar
Structure of the G60A mutant of Ras: implications for the dominant negative effect.
The Journal of biological chemistry 2005;280(27):25697-705.
2005: Anke Sparmann; Dafna Bar-Sagi
Ras oncogene and inflammation: partners in crime.
Cell cycle (Georgetown, Tex.) 2005;4(6):735-6.
2005: Natalia Jura; Herbert Archer; Dafna Bar-Sagi
Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between.
Cell research 2005;15(1):72-7.
2004: Anke Sparmann; Dafna Bar-Sagi
Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis.
Cancer cell 2004;6(5):447-58.
2004: Holger Sondermann; Stephen M Soisson; Sean Boykevisch; Shao-Song Yang; Dafna Bar-Sagi; John Kuriyan
Structural analysis of autoinhibition in the Ras activator Son of sevenless.
Cell 2004;119(3):393-405.
2004: Cristina Agbunag; Dafna Bar-Sagi
Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells.
Cancer research 2004;64(16):5659-63.
2004: Hong Joo Kim; Dafna Bar-Sagi
Modulation of signalling by Sprouty: a developing story.
Nature reviews. Molecular cell biology 2004;5(6):441-50.
2003: Holger Sondermann; Stephen M Soisson; Dafna Bar-Sagi; John Kuriyan
Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless.
Structure (London, England : 1993) 2003;11(12):1583-93.
2003: S Mariana Margarit; Holger Sondermann; Brian E Hall; Bhushan Nagar; André Hoelz; Michelle Pirruccello; Dafna Bar-Sagi; John Kuriyan
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS.
Cell 2003;112(5):685-95.
2003: Norman J Kennedy; Hayla K Sluss; Stephen N Jones; Dafna Bar-Sagi; Richard A Flavell; Roger J Davis
Suppression of Ras-stimulated transformation by the JNK signal transduction pathway.
Genes & development 2003;17(5):629-37.
2003: Hongliang Guo; Jose A Seixas-Silva; Michael W Epperly; Joan E Gretton; Dong M Shin; Dafna Bar-Sagi; Herbert Archer; Joel S Greenberger
Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene.
Radiation research 2003;159(3):361-70.
2003: Anjaruwee Nimnual; Laura J Taylor; Dafna Bar-Sagi
Redox-dependent downregulation of Rho by Rac.
Nature cell biology 2003;5(3):236-41.
2003: Amy B Hall; Natalia Jura; John DaSilva; Yeon Joo Jang; Delquin Gong; Dafna Bar-Sagi
hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl.
Current biology : CB 2003;13(4):308-14.
2003: Michael W Epperly; Hong Liang Guo; Mia Jefferson; Suhua Nie; Joan Gretton; Michael Bernarding; Dafna Bar-Sagi; Herbert Archer; Joel S Greenberger
Cell phenotype specific kinetics of expression of intratracheally injected manganese superoxide dismutase-plasmid/liposomes (MnSOD-PL) during lung radioprotective gene therapy.
Gene therapy 2003;10(2):163-71.
2002: Zaher Nahle; Julia Polakoff; Ramana V Davuluri; Mila E McCurrach; Matthew D Jacobson; Masashi Narita; Michael Q Zhang; Yuri Lazebnik; Dafna Bar-Sagi; Scott W Lowe
Direct coupling of the cell cycle and cell death machinery by E2F.
Nature cell biology 2002;4(11):859-64.
2002: Janet Farhang-Fallah; Varinder K Randhawa; Anjaruwee Nimnual; Amira Klip; Dafna Bar-Sagi; Maria Rozakis-Adcock
The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation.
Molecular and cellular biology 2002;22(20):7325-36.
2002: Brian E Hall; Dafna Bar-Sagi; Nicolas Nassar
The structural basis for the transition from Ras-GTP to Ras-GDP.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12138-42.
2002: Anjaruwee Nimnual; Dafna Bar-Sagi
The two hats of SOS.
Science's STKE : signal transduction knowledge environment 2002;2002(145):pe36.
2002: Kui Lei; Anjaruwee Nimnual; Wei-Xing Zong; Norman J Kennedy; Richard A Flavell; Craig Thompson; Dafna Bar-Sagi; Roger J Davis
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase.
Molecular and cellular biology 2002;22(13):4929-42.
2002: James Egan; Amy B Hall; Bogdan A Yatsula; Dafna Bar-Sagi
The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6041-6.
2002: Herbert Archer; Dafna Bar-Sagi
Ras and Rac as activators of reactive oxygen species (ROS).
Methods in molecular biology (Clifton, N.J.) 2002;189():67-73.
2002: Michael W Epperly; Christine A Sikora; Stacy J Defilippi; Joan E Gretton; Dafna Bar-Sagi; Herbert Archer; Timothy M Carlos; HongLiang Guo; Joel S Greenberger
Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2002;8(4):175-87.
2002: Brian E Hall; Shao-Song Yang; Dafna Bar-Sagi
Autoinhibition of Sos by intramolecular interactions.
Frontiers in bioscience : a journal and virtual library 2002;7():d288-94.
2001: Michael W Epperly; Valerian E Kagan; Christine A Sikora; Joan E Gretton; Stacy J Defilippi; Dafna Bar-Sagi; Joel S Greenberger
Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation.
International journal of cancer. Journal international du cancer 2001;96(4):221-31.
2001: Brian E Hall; S S Yang; P A Boriack-Sjodin; John Kuriyan; Dafna Bar-Sagi
Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange.
The Journal of biological chemistry 2001;276(29):27629-37.
2001: AB Walsh; Dafna Bar-Sagi
Differential activation of the Rac pathway by Ha-Ras and K-Ras.
The Journal of biological chemistry 2001;276(19):15609-15.
2001: Dafna Bar-Sagi
A Ras by any other name.
Molecular and cellular biology 2001;21(5):1441-3.
2000: Dafna Bar-Sagi; Alan Hall
Ras and Rho GTPases: a family reunion.
Cell 2000;103(2):227-38.
2000: C Tournier; P Hess; Derek D Yang; Jianchao Xu; Tod K Turner; Anjaruwee Nimnual; Dafna Bar-Sagi; Stephen N Jones; Richard A Flavell; Roger J Davis
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway.
Science (New York, N.Y.) 2000;288(5467):870-4.
2000: Joel E Schaley; RJ O'Connor; Laura J Taylor; Dafna Bar-Sagi; Patrick Hearing
Induction of the cellular E2F-1 promoter by the adenovirus E4-6/7 protein.
Journal of virology 2000;74(5):2084-93.
2000: Laura J Taylor; AB Walsh; Patrick Hearing; Dafna Bar-Sagi
Single cell assays for Rac activity.
Methods in enzymology 2000;325():327-34.
1999: T Joneson; Dafna Bar-Sagi
Suppression of Ras-induced apoptosis by the Rac GTPase.
Molecular and cellular biology 1999;19(9):5892-901.
1999: Jason D. Weber; Laura J Taylor; Martine F Roussel; Charles J Sherr; Dafna Bar-Sagi
Nucleolar Arf sequesters Mdm2 and activates p53.
Nature cell biology 1999;1(1):20-6.
1999: C Chandra Kumar; K Ohashi; K Nagata; A Walsh; Dafna Bar-Sagi; K Mizuno
SCH 51344, an inhibitor of RAS/RAC-mediated cell morphology pathway.
Annals of the New York Academy of Sciences 1999;886():122-31.
1998: Stephen M Soisson; Anjaruwee Nimnual; M Uy; Dafna Bar-Sagi; John Kuriyan
Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.
Cell 1998;95(2):259-68.
1998: P A Boriack-Sjodin; S Mariana Margarit; Dafna Bar-Sagi; John Kuriyan
The structural basis of the activation of Ras by Sos.
Nature 1998;394(6691):337-43.
1998: T Joneson; Dafna Bar-Sagi
A Rac1 effector site controlling mitogenesis through superoxide production.
The Journal of biological chemistry 1998;273(29):17991-4.
1998: T Joneson; J A Fulton; Deanna J Volle; Oleg V Chaika; Dafna Bar-Sagi; Robert Lewis
Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors.
The Journal of biological chemistry 1998;273(13):7743-8.
1998: Senena Corbalan-Garcia; S Mariana Margarit; D Galron; S S Yang; Dafna Bar-Sagi
Regulation of Sos activity by intramolecular interactions.
Molecular and cellular biology 1998;18(2):880-6.
1998: Anjaruwee Nimnual; B A Yatsula; Dafna Bar-Sagi
Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.
Science (New York, N.Y.) 1998;279(5350):560-3.
1997: J Zheng; R H Chen; S Corblan-Garcia; Sean M Cahill; Dafna Bar-Sagi; David Cowburn
The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains.
The Journal of biological chemistry 1997;272(48):30340-4.
1997: AB Walsh; M Dhanasekaran; Dafna Bar-Sagi; C Chandra Kumar
SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway.
Oncogene 1997;15(21):2553-60.
1997: T Joneson; Dafna Bar-Sagi
Ras effectors and their role in mitogenesis and oncogenesis.
Journal of molecular medicine (Berlin, Germany) 1997;75(8):587-93.
1997: R H Chen; Senena Corbalan-Garcia; Dafna Bar-Sagi
The role of the PH domain in the signal-dependent membrane targeting of Sos.
The EMBO journal 1997;16(6):1351-9.
1996: T Joneson; M McDonough; Dafna Bar-Sagi; Linda Van Aelst
RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase.
Science (New York, N.Y.) 1996;274(5291):1374-6.
1996: Senena Corbalan-Garcia; S S Yang; K R Degenhardt; Dafna Bar-Sagi
Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2.
Molecular and cellular biology 1996;16(10):5674-82.
1996: Linda Van Aelst; T Joneson; Dafna Bar-Sagi
Identification of a novel Rac1-interacting protein involved in membrane ruffling.
The EMBO journal 1996;15(15):3778-86.
1996: Senena Corbalan-Garcia; K R Degenhardt; Dafna Bar-Sagi
Insulin-induced dissociation of Sos from Grb2 does not contribute to the down regulation of Ras activation.
Oncogene 1996;12(5):1063-8.
1996: T Joneson; Michael A White; Michael Wigler; Dafna Bar-Sagi
Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.
Science (New York, N.Y.) 1996;271(5250):810-2.
1995: S S Yang; Linda Van Aelst; Dafna Bar-Sagi
Differential interactions of human Sos1 and Sos2 with Grb2.
The Journal of biological chemistry 1995;270(31):18212-5.
1995: Dafna Bar-Sagi
Mammalian cell microinjection assay.
Methods in enzymology 1995;255():436-42.
1995: M Frech; D Cussac; Pierre Chardin; Dafna Bar-Sagi
Purification of baculovirus-expressed human Sos1 protein.
Methods in enzymology 1995;255():125-9.
1994: D Rotin; Dafna Bar-Sagi; H O'Brodovich; J Merilainen; V P Lehto; C M Canessa; B C Rossier; Gregory P Downey
An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane.
The EMBO journal 1994;13(19):4440-50.
1994: M J Boyer; David H Gutmann; Francis S Collins; Dafna Bar-Sagi
Crosslinking of the surface immunoglobulin receptor in B lymphocytes induces a redistribution of neurofibromin but not p120-GAP.
Oncogene 1994;9(2):349-57.
1994: Joseph Schlessinger; Dafna Bar-Sagi
Activation of Ras and other signaling pathways by receptor tyrosine kinases.
Cold Spring Harbor symposia on quantitative biology 1994;59():173-9.
1993: I Hide; J P Bennett; Arnold Pizzey; G Boonen; Dafna Bar-Sagi; BD Gomperts; P E Tatham
Degranulation of individual mast cells in response to Ca2+ and guanine nucleotides: an all-or-none event.
The Journal of cell biology 1993;123(3):585-93.
1993: Dafna Bar-Sagi; D Rotin; A Batzer; V Mandiyan; Joseph Schlessinger
SH3 domains direct cellular localization of signaling molecules.
Cell 1993;74(1):83-91.
1993: Pierre Chardin; J H Camonis; nicholas gale; Linda Van Aelst; J Schlessinger; Michael Wigler; Dafna Bar-Sagi
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.
Science (New York, N.Y.) 1993;260(5112):1338-43.
1993: N Li; A Batzer; R Daly; V Yajnik; Edward Y Skolnik; Pierre Chardin; Dafna Bar-Sagi; Benjamin L Margolis; Joseph Schlessinger
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.
Nature 1993;363(6424):85-8.
1993: nicholas gale; S Kaplan; E J Lowenstein; Joseph Schlessinger; Dafna Bar-Sagi
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras.
Nature 1993;363(6424):88-92.
1992: E J Lowenstein; R J Daly; A G Batzer; W Li; Benjamin L Margolis; R Lammers; A Ullrich; Edward Y Skolnik; Dafna Bar-Sagi; Joseph Schlessinger
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
Cell 1992;70(3):431-42.
1991: S Kaplan; Dafna Bar-Sagi
Association of p21ras with cellular polypeptides.
The Journal of biological chemistry 1991;266(28):18934-41.
1991: L Graziadei; P Burfeind; Dafna Bar-Sagi
Introduction of unlabeled proteins into living cells by electroporation and isolation of viable protein-loaded cells using dextran-fluorescein isothiocyanate as a marker for protein uptake.
Analytical biochemistry 1991;194(1):198-203.
1990: L Graziadei; K Riabowol; Dafna Bar-Sagi
Co-capping of ras proteins with surface immunoglobulins in B lymphocytes.
Nature 1990;347(6291):396-400.
1990: Shamshad Cockcroft; Dafna Bar-Sagi
Effect of H-ras proteins on the activity of polyphosphoinositide phospholipase C in HL60 membranes.
Cellular signalling 1990;2(3):227-34.
1989: Dafna Bar-Sagi
ras proteins: biological effects and biochemical targets (review).
Anticancer research 1989;9(5):1427-37.
1989: D Kim; D L Lewis; L Graziadei; E J Neer; Dafna Bar-Sagi; D E Clapham
G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2.
Nature 1989;337(6207):557-60.
1988: Dafna Bar-Sagi; B D Gomperts
Stimulation of exocytotic degranulation by microinjection of the ras oncogene protein into rat mast cells.
Oncogene 1988;3(4):463-9.
1988: Dafna Bar-Sagi; J P Suhan; F McCormick; J R Feramisco
Localization of phospholipase A2 in normal and ras-transformed cells.
The Journal of cell biology 1988;106(5):1649-58.
1987: Dafna Bar-Sagi; A Fernandez; J R Feramisco
Regulation of membrane turnover by ras proteins.
Bioscience reports 1987;7(5):427-34.
1987: Dafna Bar-Sagi; F McCormick; R J Milley; J R Feramisco
Inhibition of cell surface ruffling and fluid-phase pinocytosis by microinjection of anti-ras antibodies into living cells.
Journal of cellular physiology. Supplement 1987;Suppl 5():69-73.