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Jacob Bar-Tana

Research Profile

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Rats
Mouse

Chemicals & Drugs

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Physiology

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Anna Algamas-Dimantov; Jacob Bar-Tana; Julius Ben-Ari; Dana Davidovsky; Rachel Hertz; Jing X Kang; Irena Peri; Betty Schwartz
Amelioration of diabesity-induced colorectal ontogenesis by omega-3 fatty acids in mice.
Bella Kalderon; Michael Valitsky; Noam Vissler; Narmen Azazmeh; Nili Azulay; Jacob Bar-Tana
Suppression of adipose lipolysis by long-chain fatty acid analogs.
Ghadeer Zatara; Amos Cahan; Haim D Danenberg; Etty Grad; Rachel Hertz; Nina Mayorek; Etedal Morad; Maayan Shaked; Terry G Unterman; Jacob Bar-Tana
Suppression of FoxO1 activity by long-chain fatty acyl analogs.

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All Publications

2012: Anna Algamas-Dimantov; Jacob Bar-Tana; Julius Ben-Ari; Dana Davidovsky; Rachel Hertz; Jing X Kang; Irena Peri; Betty Schwartz
Amelioration of diabesity-induced colorectal ontogenesis by omega-3 fatty acids in mice.
Journal of lipid research 2012;53(6):1056-70.
2012: Bella Kalderon; Michael Valitsky; Noam Vissler; Narmen Azazmeh; Nili Azulay; Jacob Bar-Tana
Suppression of adipose lipolysis by long-chain fatty acid analogs.
Journal of lipid research 2012;53(5):868-78.
2011: Ghadeer Zatara; Amos Cahan; Haim D Danenberg; Etty Grad; Rachel Hertz; Nina Mayorek; Etedal Morad; Maayan Shaked; Terry G Unterman; Jacob Bar-Tana
Suppression of FoxO1 activity by long-chain fatty acyl analogs.
Diabetes 2011;60(7):1872-81.
2010: Dmitri Samovski; Bella Kalderon; Einav Yehuda-Shnaidman; Jacob Bar-Tana
Gating of the mitochondrial permeability transition pore by long chain fatty acyl analogs in vivo.
The Journal of biological chemistry 2010;285(10):6879-90.
2010: Einav Yehuda-Shnaidman; Bella Kalderon; Narmen Azazmeh; Jacob Bar-Tana
Gating of the mitochondrial permeability transition pore by thyroid hormone.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(1):93-104.
2008: Ghadeer Za'tara; Jacob Bar-Tana; Bella Kalderon; Marianne Suter; Etedal Morad; Dmitry Samovski; Dietbert Neumann; Rachel Hertz
AMPK activation by long chain fatty acyl analogs.
Biochemical pharmacology 2008;76(10):1263-75.
2008: Irina Shabalina; Emma C Backlund; Jacob Bar-Tana; Barbara Cannon; Jan Nedergaard
Within brown-fat cells, UCP1-mediated fatty acid-induced uncoupling is independent of fatty acid metabolism.
Biochimica et biophysica acta 2008;1777(7-8):642-50.
2006: Guy Las; Nina Mayorek; Kobie Dickstein; Jacob Bar-Tana
Modulation of insulin secretion by fatty acyl analogs.
Diabetes 2006;55(12):3478-85.
2005: Vered Sheena; Rachel Hertz; Ina Berman; Janna Nousbeck; Jacob Bar-Tana
Transcriptional suppression of human microsomal triglyceride transfer protein by hypolipidemic insulin sensitizers.
Biochemical pharmacology 2005;70(11):1548-59.
2005: Rachel Hertz; Bella Kalderon; Tamara Byk; Ina Berman; Ghadeer Za'tara; Raphael Mayer; Jacob Bar-Tana
Thioesterase activity and acyl-CoA/fatty acid cross-talk of hepatocyte nuclear factor-4{alpha}.
The Journal of biological chemistry 2005;280(26):24451-61.
2005: Friedhelm Schroeder; Huan Huang; Heather A Hostetler; Anca Petrescu; Rachel Hertz; Jacob Bar-Tana; Ann B Kier
Stability of fatty acyl-coenzyme A thioester ligands of hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha.
Lipids 2005;40(6):559-68.
2005: Judith Magenheim; Rachel Hertz; Ina Berman; Janna Nousbeck; Jacob Bar-Tana
Negative autoregulation of HNF-4alpha gene expression by HNF-4alpha1.
The Biochemical journal 2005;388(Pt 1):325-32.
2005: Einav Yehuda-Shnaidman; Bella Kalderon; Jacob Bar-Tana
Modulation of mitochondrial transition pore components by thyroid hormone.
Endocrinology 2005;146(5):2462-72.
2005: Anca Petrescu; Rachel Hertz; Jacob Bar-Tana; Friedhelm Schroeder; Ann B Kier
Role of regulatory F-domain in hepatocyte nuclear factor-4alpha ligand specificity.
The Journal of biological chemistry 2005;280(17):16714-27.
2005: Vered Sheena; Rachel Hertz; Janna Nousbeck; Ina Berman; Judith Magenheim; Jacob Bar-Tana
Transcriptional regulation of human microsomal triglyceride transfer protein by hepatocyte nuclear factor-4alpha.
Journal of lipid research 2005;46(2):328-41.
2004: Myriam Bronner; Rachel Hertz; Jacob Bar-Tana
Kinase-independent transcriptional co-activation of peroxisome proliferator-activated receptor alpha by AMP-activated protein kinase.
The Biochemical journal 2004;384(Pt 2):295-305.
2004: Jacob Bar-Tana
Hypolipidemia induced by PPARalpha agonists: HNF-4alpha as an alternative to PPARalpha.
Current opinion in investigational drugs (London, England : 2000) 2004;5(9):941-6.
2003: Anca Petrescu; H Ross Payne; Amy Boedecker; Hsu Chao; Rachel Hertz; Jacob Bar-Tana; Friedhelm Schroeder; Ann B Kier
Physical and functional interaction of Acyl-CoA-binding protein with hepatocyte nuclear factor-4 alpha.
The Journal of biological chemistry 2003;278(51):51813-24.
2003: Rachel Hertz; Nadav Ben-Haim; Anca Petrescu; Bella Kalderon; Ina Berman; Naama Eldad; Friedhelm Schroeder; Jacob Bar-Tana
Rescue of MODY-1 by agonist ligands of hepatocyte nuclear factor-4alpha.
The Journal of biological chemistry 2003;278(25):22578-85.
2003: Bella Kalderon; Nina Mayorek; Limor Ben-Yaacov; Jacob Bar-Tana
Adipose tissue sensitization to insulin induced by troglitazone and MEDICA 16 in obese Zucker rats in vivo.
American journal of physiology. Endocrinology and metabolism 2003;284(4):E795-803.
2002: Reut Bartoov-Shifman; Rachel Hertz; Haiyan Wang; Claes B Wollheim; Jacob Bar-Tana; Michael D Walker
Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4 alpha.
The Journal of biological chemistry 2002;277(29):25914-9.
2002: Anca Petrescu; Rachel Hertz; Jacob Bar-Tana; Friedhelm Schroeder; Ann B Kier
Ligand specificity and conformational dependence of the hepatic nuclear factor-4alpha (HNF-4alpha ).
The Journal of biological chemistry 2002;277(27):23988-99.
2002: Bella Kalderon; Vered Sheena; S Shachrur; Rachel Hertz; Jacob Bar-Tana
Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry.
Journal of lipid research 2002;43(7):1125-32.
2002: Laura L Atkinson; Sandra Elizabeth Kelly; James C Russell; Jacob Bar-Tana; Gary D Lopaschuk
MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats.
Diabetes 2002;51(5):1548-55.
2001: Rachel Hertz; Vered Sheena; Bella Kalderon; Ina Berman; Jacob Bar-Tana
Suppression of hepatocyte nuclear factor-4alpha by acyl-CoA thioesters of hypolipidemic peroxisome proliferators.
Biochemical pharmacology 2001;61(9):1057-62.
2001: Jacob Bar-Tana
Peroxisome proliferator-activated receptor gamma (PPARgamma) activation and its consequences in humans.
Toxicology letters 2001;120(1-3):9-19.
2000: Bella Kalderon; Nina Mayorek; E Berry; N Zevit; Jacob Bar-Tana
Fatty acid cycling in the fasting rat.
American journal of physiology. Endocrinology and metabolism 2000;279(1):E221-7.
2000: O Hermesh; Bella Kalderon; B Berman; Jacob Bar-Tana
Mitochondrial protonophoric activity induced by a thyromimetic fatty acid analogue.
Biochimica et biophysica acta 2000;1457(3):166-74.
1998: Rachel Hertz; Jacob Bar-Tana
Peroxisome proliferator-activated receptor (PPAR) alpha activation and its consequences in humans.
Toxicology letters 1998;102-103():85-90.
1998: James C Russell; Gillian Shillabeer; Jacob Bar-Tana; David C W Lau; M Richardson; L M Wenzel; Sandra Elizabeth Kelly; Peter J Dolphin
Development of insulin resistance in the JCR:LA-cp rat: role of triacylglycerols and effects of MEDICA 16.
Diabetes 1998;47(5):770-8.
1998: Rachel Hertz; Judith Magenheim; Ina Berman; Jacob Bar-Tana
Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4alpha.
Nature 1998;392(6675):512-6.
1998: O Hermesh; Bella Kalderon; Jacob Bar-Tana
Mitochondria uncoupling by a long chain fatty acyl analogue.
The Journal of biological chemistry 1998;273(7):3937-42.
1997: Nina Mayorek; Bella Kalderon; E Itach; Jacob Bar-Tana
Sensitization to insulin induced by beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in obese Zucker rats in vivo.
Diabetes 1997;46(12):1958-64.
1996: Rachel Hertz; J Bishara-Shieban; Jacob Bar-Tana
Hypolipidemic effect of peroxisome proliferators. Transcriptional suppression of apolipoprotein C-III.
Annals of the New York Academy of Sciences 1996;804():731-3.
1996: Rachel Hertz; V Nikodem; A Ben-Ishai; I Berman; Jacob Bar-Tana
Thyromimetic mode of action of peroxisome proliferators: activation of 'malic' enzyme gene transcription.
The Biochemical journal 1996;319 ( Pt 1)():241-8.
1996: Rachel Hertz; I Berman; D Keppler; Jacob Bar-Tana
Activation of gene transcription by prostacyclin analogues is mediated by the peroxisome-proliferators-activated receptor (PPAR).
European journal of biochemistry / FEBS 1996;235(1-2):242-7.
1996: Rachel Hertz; M Seckbach; M M Zakin; Jacob Bar-Tana
Transcriptional suppression of the transferrin gene by hypolipidemic peroxisome proliferators.
The Journal of biological chemistry 1996;271(1):218-24.
1995: R Brandes; R Arad; Jacob Bar-Tana
Inducers of adipose conversion activate transcription promoted by a peroxisome proliferators response element in 3T3-L1 cells.
Biochemical pharmacology 1995;50(11):1949-51.
1995: Bella Kalderon; O Hermesh; Jacob Bar-Tana
Mitochondrial permeability transition is induced by in vivo thyroid hormone treatment.
Endocrinology 1995;136(8):3552-6.
1995: James C Russell; RM Amy; Sandra Elizabeth Kelly; P J Dolphin; G O Wood; Jacob Bar-Tana
Inhibition of atherosclerosis and myocardial lesions in the JCR:LA-cp rat by beta, beta'-tetramethylhexadecanedioic acid (MEDICA 16).
Arteriosclerosis, thrombosis, and vascular biology 1995;15(7):918-23.
1995: Rachel Hertz; J Bishara-Shieban; Jacob Bar-Tana
Mode of action of peroxisome proliferators as hypolipidemic drugs. Suppression of apolipoprotein C-III.
The Journal of biological chemistry 1995;270(22):13470-5.
1994: Rachel Hertz; I Berman; Jacob Bar-Tana
Transcriptional activation by amphipathic carboxylic peroxisomal proliferators is induced by the free acid rather than the acyl-CoA derivative.
European journal of biochemistry / FEBS 1994;221(1):611-5.
1994: B Frenkel; J Bishara-Shieban; Jacob Bar-Tana
The effect of beta,beta'-tetramethylhexadecanedioic acid (MEDICA 16) on plasma very-low-density lipoprotein metabolism in rats: role of apolipoprotein C-III.
The Biochemical journal 1994;298 ( Pt 2)():409-14.
1993: R Brandes; R Arad; A Gaathon; Jacob Bar-Tana
Induction of adipose conversion in 3T3-L1 cells is associated with an early phosphorylation of a protein partly homologous with mouse vimentin.
FEBS letters 1993;333(1-2):179-82.
1993: N Mayorek; Jacob Bar-Tana
Hypocholesterolaemic effect of beta beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in the male hamster.
The Biochemical journal 1993;289 ( Pt 3)():911-7.
1993: Rachel Hertz; Bella Kalderon; Jacob Bar-Tana
Thyromimetic effect of peroxisome proliferators.
Biochimie 1993;75(3-4):257-61.
1992: Bella Kalderon; Rachel Hertz; Jacob Bar-Tana
Tissue selective modulation of redox and phosphate potentials by beta,beta'-methyl-substituted hexadecanedioic acid.
Endocrinology 1992;131(4):1629-35.
1992: Bella Kalderon; Rachel Hertz; Jacob Bar-Tana
Effect of thyroid hormone treatment on redox and phosphate potentials in rat liver.
Endocrinology 1992;131(1):400-7.
1992: Rachel Hertz; Jacob Bar-Tana
Induction of peroxisomal beta-oxidation genes by retinoic acid in cultured rat hepatocytes.
The Biochemical journal 1992;281 ( Pt 1)():41-3.
1991: R Brandes; R Arad; Jacob Bar-Tana
The induction of adipose conversion in 3T3-L1 cells is associated with early phosphorylation of a 60-kDa nuclear protein.
FEBS letters 1991;285(1):63-5.
1991: James C Russell; P J Dolphin; M Hameed; B Stewart; D G Koeslag; G Rose-Kahn; Jacob Bar-Tana
Hypolipidemic effect of beta, beta'-tetramethyl hexadecanedioic acid (MEDICA 16) in hyperlipidemic JCR:LA-corpulent rats.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(3):602-9.
1991: Rachel Hertz; R Aurbach; T Hashimoto; Jacob Bar-Tana
Thyromimetic effect of peroxisomal proliferators in rat liver.
The Biochemical journal 1991;274 ( Pt 3)():745-51.
1990: M Almagor; Jacob Bar-Tana
Retinoic acid inhibits the myristoylation of a membrane protein in HL-60 cells.
Biochemical and biophysical research communications 1990;172(2):877-82.
1990: R Brandes; R Arad; Nissim Benvenisty; S Weil; Jacob Bar-Tana
The induction of adipose conversion by bezafibrate in 3T3-L1 cells. Synergism with dibutyryl-cAMP.
Biochimica et biophysica acta 1990;1054(2):219-24.
1990: G Rose-Kahn; Jacob Bar-Tana
Inhibition of rat liver acetyl-CoA carboxylase by beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16).
Biochimica et biophysica acta 1990;1042(2):259-64.
1989: Jacob Bar-Tana; S Ben-Shoshan; J Blum; Y Migron; Rachel Hertz; Johannes Pill; G Rose-Khan; E C Witte
Synthesis and hypolipidemic and antidiabetogenic activities of beta,beta,beta',beta'-tetrasubstituted, long-chain dioic acids.
Journal of medicinal chemistry 1989;32(9):2072-84.
1989: N Mayorek; I Grinstein; Jacob Bar-Tana
Triacylglycerol synthesis in cultured rat hepatocytes. The rate-limiting role of diacylglycerol acyltransferase.
European journal of biochemistry / FEBS 1989;182(2):395-400.
1989: N Mayorek; Jacob Bar-Tana
Lipid synthesis in permeabilized cultured rat hepatocytes.
The Journal of biological chemistry 1989;264(8):4450-5.
1989: G Rosen; Jacob Bar-Tana
Fatty acyl coupled catalase.
Biochimica et biophysica acta 1989;994(3):264-9.
1989: R Tzur; E Smith; Jacob Bar-Tana
Adipose reduction by beta,beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16).
International journal of obesity 1989;13(3):313-26.
1988: R Tzur; G Rose-Kahn; J H Adler; Jacob Bar-Tana
Hypolipidemic, antiobesity, and hypoglycemic-hypoinsulinemic effects of beta,beta'-methyl-substituted hexadecanedioic acid in sand rats.
Diabetes 1988;37(12):1618-24.
1988: Rachel Hertz; Jacob Bar-Tana; M Sujatta; Johannes Pill; F H Schmidt; H Dariush Fahimi
The induction of liver peroxisomal proliferation by beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16).
Biochemical pharmacology 1988;37(19):3571-7.
1988: Rachel Hertz; Jacob Bar-Tana
The acylation of proteins by xenobiotic amphipathic carboxylic acids in cultured rat hepatocytes.
The Biochemical journal 1988;254(1):39-44.
1988: B Frenkel; N Mayorek; Rachel Hertz; Jacob Bar-Tana
The hypochylomicronemic effect of beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) is mediated by a decrease in apolipoprotein C-III.
The Journal of biological chemistry 1988;263(17):8491-7.
1988: Jacob Bar-Tana; G Rose-Kahn; B Frenkel; Z Shafer; Menahem Fainaru
Hypolipidemic effect of beta, beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in normal and nephrotic rats.
Journal of lipid research 1988;29(4):431-41.
1987: Rachel Hertz; Jacob Bar-Tana
Prevention of peroxisomal proliferation by carnitine palmitoyltransferase inhibitors in cultured rat hepatocytes and in vivo.
The Biochemical journal 1987;245(2):387-92.
1987: R Brandes; Rachel Hertz; R Arad; S Naishtat; S Weil; Jacob Bar-Tana
Adipocyte conversion of cultured 3T3-L1 preadipocytes by bezafibrate.
Life sciences 1987;40(10):935-41.
1987: Rachel Hertz; J Arnon; A Hoter; Daniel Shouval; Jacob Bar-Tana
Clofibrate does not induce peroxisomal proliferation in human hepatoma cell lines PLC/PRF/5 and SK-HEP-1.
Cancer letters 1987;34(3):263-72.
1987: Rachel Hertz; Jacob Bar-Tana
Increased response to peroxisomal proliferators in starved rats.
Biochimica et biophysica acta 1987;917(1):57-61.
1986: R Brandes; R Arad; Jacob Bar-Tana
Adipose conversion of cultured rat primary preadipocytes by hypolipidemic drugs.
Biochimica et biophysica acta 1986;877(2):314-21.
1985: Rachel Hertz; J Arnon; Jacob Bar-Tana
The effect of bezafibrate and long-chain fatty acids on peroxisomal activities in cultured rat hepatocytes.
Biochimica et biophysica acta 1985;836(2):192-200.
1985: R Brandes; N Mayorek; E Berry; R Arad; Jacob Bar-Tana
The specificity of triacylglycerol synthesis for medium-chain fatty acids in rat and human adipose preparations.
Biochimica et biophysica acta 1985;836(1):63-6.
1985: G Rose-Kahn; Jacob Bar-Tana
Inhibition of lipid synthesis by beta beta'-tetramethyl-substituted, C14-C22, alpha, omega-dicarboxylic acids in cultured rat hepatocytes.
The Journal of biological chemistry 1985;260(14):8411-5.
1985: Jacob Bar-Tana; G Rose-Kahn; M Srebnik
Inhibition of lipid synthesis by beta beta'-tetramethyl-substituted, C14-C22, alpha, omega-dicarboxylic acids in the rat in vivo.
The Journal of biological chemistry 1985;260(14):8404-10.
1985: N Mayorek; Jacob Bar-Tana
Inhibition of diacylglycerol acyltransferase by 2-bromooctanoate in cultured rat hepatocytes.
The Journal of biological chemistry 1985;260(11):6528-32.
1983: N Mayorek; Jacob Bar-Tana
Medium chain fatty acids as specific substrates for diglyceride acyltransferase in cultured hepatocytes.
The Journal of biological chemistry 1983;258(11):6789-92.
1981: R Brandes; R Arad; Jacob Bar-Tana
Translocation of long chain fatty acids into lecithin liposomes containing the long chain fatty acyl-CoA synthetase.
FEBS letters 1981;123(2):295-9.