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Robert Lechleider

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John A Blake-Haskins; Robert J Lechleider; Robert J Kreitman
Thrombotic microangiopathy with targeted cancer agents.
Robert J Lechleider; Philip M Arlen; Kwong-Yok Tsang; Seth M Steinberg; Junko Yokokawa; Vittore Cereda; Kevin A Camphausen; Jeffrey Schlom; William L Dahut; James L Gulley
Safety and immunologic response of a viral vaccine to prostate-specific antigen in combination with radiation therapy when metronomic-dose interleukin 2 is used as an adjuvant.
Robert J Lechleider; Edvardas Kaminskas; Xiaoping Jiang; Robeena Aziz; Julie Bullock; Ravindra Kasliwal; Ravi Harapanhalli; Sarah Pope; R Sridhara; John Leighton; Brian Booth; Ramzi Dagher; Robert Justice; Richard Pazdur
Ixabepilone in combination with capecitabine and as monotherapy for treatment of advanced breast cancer refractory to previous chemotherapies.

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All Publications

2011: John A Blake-Haskins; Robert J Lechleider; Robert J Kreitman
Thrombotic microangiopathy with targeted cancer agents.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(18):5858-66.
2008: Robert J Lechleider; Philip M Arlen; Kwong-Yok Tsang; Seth M Steinberg; Junko Yokokawa; Vittore Cereda; Kevin A Camphausen; Jeffrey Schlom; William L Dahut; James L Gulley
Safety and immunologic response of a viral vaccine to prostate-specific antigen in combination with radiation therapy when metronomic-dose interleukin 2 is used as an adjuvant.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(16):5284-91.
2008: Robert J Lechleider; Edvardas Kaminskas; Xiaoping Jiang; Robeena Aziz; Julie Bullock; Ravindra Kasliwal; Ravi Harapanhalli; Sarah Pope; R Sridhara; John Leighton; Brian Booth; Ramzi Dagher; Robert Justice; Richard Pazdur
Ixabepilone in combination with capecitabine and as monotherapy for treatment of advanced breast cancer refractory to previous chemotherapies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(14):4378-84.
2007: Nima Sharifi; Robert J Lechleider; William L Farrar
Transforming growth factor-beta receptor III downregulation in prostate cancer: is inhibin B a tumor suppressor in prostate?
Journal of molecular endocrinology 2007;39(5):329-32.
2007: Young H Lee; Usamah S Kayyali; Anne Marie Sousa; Thomas Rajan; Robert J Lechleider; Regina M Day
Transforming growth factor-beta1 effects on endothelial monolayer permeability involve focal adhesion kinase/Src.
American journal of respiratory cell and molecular biology 2007;37(4):485-93.
2006: Makiko Fujii; Lyudmila A Lyakh; Cameron P Bracken; Junya Fukuoka; Morisada Hayakawa; Toshio Tsukiyama; Steven J Soll; Melissa Harris; Sonia Rocha; Kevin C Roche; Shin-ichi Tominaga; Jin Jen; Neil D Perkins; Robert J Lechleider; Anita B Roberts
SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes.
Molecular cell 2006;24(5):771-83.
2006: Victorino R Briones; Shiyou Chen; Anna T Riegel; Robert J Lechleider
Mechanism of fibroblast growth factor-binding protein 1 repression by TGF-beta.
Biochemical and biophysical research communications 2006;345(2):595-601.
2006: Shiyou Chen; Michelle Crawford; Regina M Day; Victorino R Briones; Jennifer E Leader; Pedro Jose; Robert J Lechleider
RhoA modulates Smad signaling during transforming growth factor-beta-induced smooth muscle differentiation.
The Journal of biological chemistry 2006;281(3):1765-70.
2004: Pilar Frontelo; Jennifer E Leader; Naomi Yoo; Alex C Potocki; Michelle Crawford; Magdalena Kulik; Robert J Lechleider
Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression.
Oncogene 2004;23(30):5242-51.
2004: Shiyou Chen; Robert J Lechleider
Transforming growth factor-beta-induced differentiation of smooth muscle from a neural crest stem cell line.
Circulation research 2004;94(9):1195-202.
2003: Shiyou Chen; Magdalena Kulik; Robert J Lechleider
Smad proteins regulate transcriptional induction of the SM22alpha gene by TGF-beta.
Nucleic acids research 2003;31(4):1302-10.
2002: Yin Lin; Jennifer Martin; Cornelia Gruendler; Jennifer Farley; Xianwang Meng; Bi-Yu Li; Robert J Lechleider; Carla Huff; Richard H Kim; William A Grasser; Vishwas Paralkar; Tongwen Wang
A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs).
BMC cell biology 2002;3():15.
2002: Beth L Roman; Van N Pham; Nathan D Lawson; Magdalena Kulik; Sarah Childs; Arne C Lekven; Deborah M Garrity; Randall T Moon; Mark C Fishman; Robert J Lechleider; Brant M Weinstein
Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels.
Development (Cambridge, England) 2002;129(12):3009-19.
2002: Shixia Huang; Binwu Tang; Dmitry Usoskin; Robert J Lechleider; Soazik Jamin; Cuiling Li; Mario A Anzano; Ted Ebendal; Chuxia Deng; Anita B Roberts
Conditional knockout of the Smad1 gene.
Genesis (New York, N.Y. : 2000) 2002;32(2):76-9.
2001: Robert J Lechleider; J L Ryan; L Garrett; C Eng; C Deng; A Wynshaw-Boris; A B Roberts
Targeted mutagenesis of Smad1 reveals an essential role in chorioallantoic fusion.
Developmental biology 2001;240(1):157-67.
2001: Franck Verrecchia; L Vindevoghel; Robert J Lechleider; Jouni Uitto; Anita B Roberts; Alain Mauviel
Smad3/AP-1 interactions control transcriptional responses to TGF-beta in a promoter-specific manner.
Oncogene 2001;20(26):3332-40.
2001: W Tony Parks; David B Frank; C Huff; C Renfrew Haft; J Martin; X Meng; Mark de Caestecker; James G McNally; A Reddi; Simeon I Taylor; Anita B Roberts; Tongwen Wang; Robert J Lechleider
Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases.
The Journal of biological chemistry 2001;276(22):19332-9.
2001: Jens U Wurthner; David B Frank; Angelina Felici; H M Green; Z Cao; M D Schneider; James G McNally; Robert J Lechleider; Anita B Roberts
Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone.
The Journal of biological chemistry 2001;276(22):19495-502.
2000: Sarit Larisch; Y Yi; Rona Lotan; Hedviga Kerner; Sarah Eimerl; W Tony Parks; Yossi Gottfried; S Birkey Reffey; Mark de Caestecker; David Danielpour; N Book-Melamed; Rina Timberg; Colin S Duckett; Robert J Lechleider; Hermann Steller; Joseph Orly; S J Kim; Anita B Roberts
A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif.
Nature cell biology 2000;2(12):915-21.
2000: Richard H Kim; D Wang; Michael Tsang; J Martin; C Huff; Mark de Caestecker; W Tony Parks; X Meng; Robert J Lechleider; Tongwen Wang; Anita B Roberts
A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction.
Genes & development 2000;14(13):1605-16.
2000: Tetsuro Yahata; Mark de Caestecker; Robert J Lechleider; S Andriole; Anita B Roberts; Kurt J Isselbacher; Toshi Shioda
The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors.
The Journal of biological chemistry 2000;275(12):8825-34.
2000: Mark de Caestecker; Tetsuro Yahata; D Wang; W Tony Parks; S Huang; C S Hill; Toshi Shioda; Anita B Roberts; Robert J Lechleider
The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain.
The Journal of biological chemistry 2000;275(3):2115-22.
2000: S Larisch-Bloch; David Danielpour; N S Roche; R Lotan; Andrew Y Hsing; Hedviga Kerner; T Hajouj; Robert J Lechleider; Anita B Roberts
Selective loss of the transforming growth factor-beta apoptotic signaling pathway in mutant NRP-154 rat prostatic epithelial cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000;11(1):1-10.
1999: Xiao Yang; John J Letterio; Robert J Lechleider; Lin Chen; R Hayman; H Gu; Anita B Roberts; Chuxia Deng
Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta.
The EMBO journal 1999;18(5):1280-91.
1998: L Vindevoghel; Robert J Lechleider; A Kon; Mark de Caestecker; Jouni Uitto; Anita B Roberts; Alain Mauviel
SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14769-74.
1998: Toshi Shioda; Robert J Lechleider; Sally L Dunwoodie; H Li; Tetsuro Yahata; Mark de Caestecker; Martin Fenner; Anita B Roberts; Kurt J Isselbacher
Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):9785-90.
1998: Mark de Caestecker; W Tony Parks; C J Frank; P Castagnino; Donald Bottaro; Anita B Roberts; Robert J Lechleider
Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases.
Genes & development 1998;12(11):1587-92.
1998: L Vindevoghel; A Kon; Robert J Lechleider; Jouni Uitto; Anita B Roberts; Alain Mauviel
Smad-dependent transcriptional activation of human type VII collagen gene (COL7A1) promoter by transforming growth factor-beta.
The Journal of biological chemistry 1998;273(21):13053-7.
1997: Mark de Caestecker; P Hemmati; S Larisch-Bloch; R Ajmera; Anita B Roberts; Robert J Lechleider
Characterization of functional domains within Smad4/DPC4.
The Journal of biological chemistry 1997;272(21):13690-6.
1996: Robert J Lechleider; Mark de Caestecker; A Dehejia; Mihael H Polymeropoulos; Anita B Roberts
Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1.
The Journal of biological chemistry 1996;271(30):17617-20.
1992: S B Jakowlew; Robert J Lechleider; A G Geiser; Seong-Jin Kim; Tomás Santa Coloma; J Cubert; Michael B. Sporn; Anita B Roberts
Identification and characterization of the chicken transforming growth factor-beta 3 promoter.
Molecular endocrinology (Baltimore, Md.) 1992;6(8):1285-98.
1991: Robert Lafyatis; Robert J Lechleider; Anita B Roberts; Michael B. Sporn
Secretion and transcriptional regulation of transforming growth factor-beta 3 during myogenesis.
Molecular and cellular biology 1991;11(7):3795-803.
1991: Anita B Roberts; Seong-Jin Kim; T Noma; A B Glick; Robert Lafyatis; Robert J Lechleider; S B Jakowlew; A Geiser; M A O'Reilly; David Danielpour
Multiple forms of TGF-beta: distinct promoters and differential expression.
Ciba Foundation symposium 1991;157():7-15; discussion 15-28.
1990: Robert Lafyatis; Robert J Lechleider; Seong-Jin Kim; S Jakowlew; Anita B Roberts; Michael B. Sporn
Structural and functional characterization of the transforming growth factor beta 3 promoter. A cAMP-responsive element regulates basal and induced transcription.
The Journal of biological chemistry 1990;265(31):19128-36.
1990: Anita B Roberts; Seong-Jin Kim; P Kondaiah; S B Jakowlew; F Denhez; A B Glick; A G Geiser; S Watanabe; T Noma; Robert J Lechleider
Transcriptional control of expression of the TGF-betas.
Annals of the New York Academy of Sciences 1990;593():43-50.