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Deborah Leckband

Research Profile

Chemicals & Drugs

Physiology

Cell Adhesion

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Publications

TOP 3
B-C Choi; S Choi; Deborah E Leckband
Poly(N-isopropyl acrylamide) Brush Topography: Dependence on Grafting Conditions and Temperature.
Mingxing Ouyang; Albert B Reynolds; Martin A Schwartz; Jihye Seong; Fei Wang; Chin-En Chen; Taejin Kim; Deborah E Leckband; Shaoying Lu; Yingxiao Wang
N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways.
Floor Twiss; Suzanne Van Der Horst; Gerard Van Der Krogt; Ning Wang; Stephan Huveneers; Quint Le Duc; Deborah E Leckband; Holger Rehmann; Hamid Tabdili; Johan de Rooij
Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation.

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All Publications

2013: B-C Choi; S Choi; Deborah E Leckband
Poly(N-isopropyl acrylamide) Brush Topography: Dependence on Grafting Conditions and Temperature.
Langmuir : the ACS journal of surfaces and colloids 2013;29(19):5841-50.
2013: Mingxing Ouyang; Albert B Reynolds; Martin A Schwartz; Jihye Seong; Fei Wang; Chin-En Chen; Taejin Kim; Deborah E Leckband; Shaoying Lu; Yingxiao Wang
N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways.
Nature communications 2013;4():1589.
2012: Floor Twiss; Suzanne Van Der Horst; Gerard Van Der Krogt; Ning Wang; Stephan Huveneers; Quint Le Duc; Deborah E Leckband; Holger Rehmann; Hamid Tabdili; Johan de Rooij
Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation.
Biology open 2012;1(11):1128-40.
2012: Deborah E Leckband; S Sivasankar
Cadherin recognition and adhesion.
Current opinion in cell biology 2012;24(5):620-7.
2012: Hamid Tabdili; Ning Wang; Matthew Langer; Yeh-Chuin Poh; Quanming Shi; Deborah E Leckband
Cadherin-dependent mechanotransduction depends on ligand identity but not affinity.
Journal of cell science 2012;125(Pt 18):4362-71.
2012: Hamid Tabdili; Keng Jin Lee; Shaoying Lu; Quanming Shi; Adrienne K Barry; Yuan-Hung Chien; Matthew D Langer; Deborah E Leckband
Cadherin point mutations alter cell sorting and modulate GTPase signaling.
Journal of cell science 2012;125(Pt 14):3299-309.
2012: Matthew D Langer; J Michael Pierce; Nitesh Shashikanth; Huabei Guo; Deborah E Leckband
N-glycosylation alters cadherin-mediated intercellular binding kinetics.
Journal of cell science 2012;125(Pt 10):2478-85.
2012: Deborah E Leckband; S Sivasankar
Biophysics of cadherin adhesion.
Sub-cellular biochemistry 2012;60():63-88.
2011: Deborah E Leckband
Novel functions and binding mechanisms of carbohydrate-binding proteins determined by force measurements.
Current protein & peptide science 2011;12(8):743-59.
2011: Paula Parreira; Celso A Reis; Ricardo Vidal; Joana Gomes; Inês C Gonçalves; Deborah E Leckband; Ana Magalhães; M Cristina L Martins
Effect of surface chemistry on bacterial adhesion, viability, and morphology.
Journal of biomedical materials research. Part A 2011;99(3):344-53.
2011: Deborah E Leckband; Ning Wang; Quint le Duc; Johan de Rooij
Mechanotransduction at cadherin-mediated adhesions.
Current opinion in cell biology 2011;23(5):523-30.
2011: Mirjam Andreasson-Ochsner; Maria Håkanson; Deborah E Leckband; Gregory Romano; Michael L Smith; Marcus Textor; Erik Reimhult
Single cell 3-D platform to study ligand mobility in cell-cell contact.
Lab on a chip 2011;11(17):2876-83.
2011: Changying Xue; Nihan Yonet-Tanyeri; Paul V Braun; Nicolas Brouette; Michele Sferrazza; Deborah E Leckband
Protein adsorption on poly(N-isopropylacrylamide) brushes: dependence on grafting density and chain collapse.
Langmuir : the ACS journal of surfaces and colloids 2011;27(14):8810-8.
2011: Deborah E Leckband; Sindhu Menon; Kenneth Rosenberg; Maureen E Taylor; Sarah A Graham; Kurt Drickamer
Geometry and adhesion of extracellular domains of DC-SIGNR neck length variants analyzed by force-distance measurements.
Biochemistry 2011;50(27):6125-32.
2010: Dong Li; Jiaxi Zhou; Lu Wang; Myung Eun Shin; Pei Su; Xiaohua Lei; Haibin Kuang; Weixiang Guo; Hong Yang; Linzhao Cheng; Tetsuya S Tanaka; Deborah E Leckband; Albert B Reynolds; Enkui Duan; Fei Wang
Integrated biochemical and mechanical signals regulate multifaceted human embryonic stem cell functions.
The Journal of cell biology 2010;191(3):631-44.
2010: Quanming Shi; Venkat Maruthamuthu; Fang Li; Deborah E Leckband
Allosteric cross talk between cadherin extracellular domains.
Biophysical journal 2010;99(1):95-104.
2010: Deborah E Leckband
Design rules for biomolecular adhesion: lessons from force measurements.
Annual review of chemical and biomolecular engineering 2010;1():365-89.
2009: Jonathan Silvestre; Paul J A Kenis; Deborah E Leckband
Cadherin and integrin regulation of epithelial cell migration.
Langmuir : the ACS journal of surfaces and colloids 2009;25(17):10092-9.
2009: Sindhu Menon; Kenneth Rosenberg; Sarah A Graham; Eliot M Ward; Maureen E Taylor; Kurt Drickamer; Deborah E Leckband
Binding-site geometry and flexibility in DC-SIGN demonstrated with surface force measurements.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(28):11524-9.
2009: Venkat Maruthamuthu; Klaus Schulten; Deborah E Leckband
Elasticity and rupture of a multi-domain neural cell adhesion molecule complex.
Biophysical journal 2009;96(8):3005-14.
2008: Quanming Shi; Yuan-Hung Chien; Deborah E Leckband
Biophysical properties of cadherin bonds do not predict cell sorting.
The Journal of biological chemistry 2008;283(42):28454-63.
2008: Shy Chyi Wuang; Koon-Gee Neoh; En-Tang Kang; Daniel W Pack; Deborah E Leckband
HER-2-mediated endocytosis of magnetic nanospheres and the implications in cell targeting and particle magnetization.
Biomaterials 2008;29(14):2270-9.
2008: Deborah E Leckband
Beyond structure: mechanism and dynamics of intercellular adhesion.
Biochemical Society transactions 2008;36(Pt 2):213-20.
2007: Veronika I Zarnitsyna; Jun Huang; Fang Zhang; Yuan-Hung Chien; Deborah E Leckband; Cheng Zhu
Memory in receptor-ligand-mediated cell adhesion.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(46):18037-42.
2007: Anne Pierres; Anil Prakasam; Dominique Touchard; Anne-Marie Benoliel; Pierre Bongrand; Deborah E Leckband
Dissecting subsecond cadherin bound states reveals an efficient way for cells to achieve ultrafast probing of their environment.
FEBS letters 2007;581(9):1841-6.
2007: Marco V Bayas; Alice Kearney; Adam Avramovic; Philip van der Merwe; Deborah E Leckband
Impact of salt bridges on the equilibrium binding and adhesion of human CD2 and CD58.
The Journal of biological chemistry 2007;282(8):5589-96.
2007: Rui Dong; Tor W Jensen; Kristin Engberg; Ralph G Nuzzo; Deborah E Leckband
Variably elastic hydrogel patterned via capillary action in microchannels.
Langmuir : the ACS journal of surfaces and colloids 2007;23(3):1483-8.
2007: Xiulin Zhu; C Yan; FM Winnik; Deborah E Leckband
End-grafted low-molecular-weight PNIPAM does not collapse above the LCST.
Langmuir : the ACS journal of surfaces and colloids 2007;23(1):162-9.
2006: Fang Li; Deborah E Leckband
Dynamic strength of molecularly bonded surfaces.
The Journal of chemical physics 2006;125(19):194702.
2006: Anil Prakasam; V Maruthamuthu; Deborah E Leckband
Similarities between heterophilic and homophilic cadherin adhesion.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(42):15434-9.
2006: Anil Prakasam; Y-H Chien; V Maruthamuthu; Deborah E Leckband
Calcium site mutations in cadherin: impact on adhesion and evidence of cooperativity.
Biochemistry 2006;45(22):6930-9.
2006: Kyle N Plunkett; Xi Zhu; Jeffrey S Moore; Deborah E Leckband
PNIPAM chain collapse depends on the molecular weight and grafting density.
Langmuir : the ACS journal of surfaces and colloids 2006;22(9):4259-66.
2006: Rico C Gunawan; Jonathan Silvestre; H. Rex Gaskins; Paul J A Kenis; Deborah E Leckband
Cell migration and polarity on microfabricated gradients of extracellular matrix proteins.
Langmuir : the ACS journal of surfaces and colloids 2006;22(9):4250-8.
2006: Chun Yan; Wakana Matsuda; David R Pepperberg; Steven C Zimmerman; Deborah E Leckband
Synthesis and characterization of an electroactive surface that releases gamma-aminobutyric acid (GABA).
Journal of colloid and interface science 2006;296(1):165-77.
2006: Marco V Bayas; Andrew Leung; Evan Evans; Deborah E Leckband
Lifetime measurements reveal kinetic differences between homophilic cadherin bonds.
Biophysical journal 2006;90(4):1385-95.
2006: Deborah E Leckband; Anil Prakasam
Mechanism and dynamics of cadherin adhesion.
Annual review of biomedical engineering 2006;8():259-87.
2005: Julie A Wieland; Andrew A Gewirth; Deborah E Leckband
Single molecule adhesion measurements reveal two homophilic neural cell adhesion molecule bonds with mechanically distinct properties.
The Journal of biological chemistry 2005;280(49):41037-46.
2005: E J Hukkanen; Julie A Wieland; Andrew A Gewirth; Deborah E Leckband; Richard D Braatz
Multiple-bond kinetics from single-molecule pulling experiments: evidence for multiple NCAM bonds.
Biophysical journal 2005;89(5):3434-45.
2005: Julie A Wieland; Andrew A Gewirth; Deborah E Leckband
Single-molecule measurements of the impact of lipid phase behavior on anchor strengths.
The journal of physical chemistry. B 2005;109(12):5985-93.
2005: Rico C Gunawan; Eric R Choban; John E Conour; Jonathan Silvestre; Lawrence B Schook; H. Rex Gaskins; Deborah E Leckband; Paul J A Kenis
Regiospecific control of protein expression in cells cultured on two-component counter gradients of extracellular matrix proteins.
Langmuir : the ACS journal of surfaces and colloids 2005;21(7):3061-8.
2005: Andrew L Hauck; Kelly S Swanson; Paul J A Kenis; Deborah E Leckband; H. Rex Gaskins; Lawrence B Schook
Twists and turns in the development and maintenance of the mammalian small intestine epithelium.
Birth defects research. Part C, Embryo today : reviews 2005;75(1):58-71.
2005: Colin P Johnson; Giovanna Fragneto; Oleg Konovalov; Virginie Dubosclard; Jean-Francois Legrand; Deborah E Leckband
Structural studies of the neural-cell-adhesion molecule by X-ray and neutron reflectivity.
Biochemistry 2005;44(2):546-54.
2005: Colin P Johnson; Ichiro Fujimoto; Urs Rutishauser; Deborah E Leckband
Direct evidence that neural cell adhesion molecule (NCAM) polysialylation increases intermembrane repulsion and abrogates adhesion.
The Journal of biological chemistry 2005;280(1):137-45.
2004: Xiulin Zhu; J Degraaf; FM Winnik; Deborah E Leckband
pH-dependent mucoadhesion of a poly(N-isopropylacrylamide) copolymer reveals design rules for drug delivery.
Langmuir : the ACS journal of surfaces and colloids 2004;20(24):10648-56.
2004: Wei Tan; Aylin Sendemir-Urkmez; Lester J Fahrner; Russell D Jamison; Deborah E Leckband; Allen Stephen Boppart
Structural and functional optical imaging of three-dimensional engineered tissue development.
Tissue engineering 2004;10(11-12):1747-56.
2004: Deborah E Leckband
Nanomechanics of adhesion proteins.
Current opinion in structural biology 2004;14(5):524-30.
2004: Marco V Bayas; Klaus Schulten; Deborah E Leckband
Forced dissociation of the strand dimer interface between C-cadherin ectodomains.
Mechanics & chemistry of biosystems : MCB 2004;1(2):101-11.
2004: Colin P Johnson; Ichiro Fujimoto; Claire Perrin-Tricaud; Urs Rutishauser; Deborah E Leckband
Mechanism of homophilic adhesion by the neural cell adhesion molecule: use of multiple domains and flexibility.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):6963-8.
2004: Xiulin Zhu; J DeGraaf; FM Winnik; Deborah E Leckband
Tuning the interfacial properties of grafted chains with a pH switch.
Langmuir : the ACS journal of surfaces and colloids 2004;20(4):1459-65.
2003: Colin P Johnson; Irene E Jensen; Anil Prakasam; Ravi Vijayendran; Deborah E Leckband
Engineered protein a for the orientational control of immobilized proteins.
Bioconjugate chemistry 2003;14(5):974-8.
2003: B Zhu; Sophie Chappuis-Flament; E Wong; I E Jensen; BM Gumbiner; Deborah E Leckband
Functional analysis of the structural basis of homophilic cadherin adhesion.
Biophysical journal 2003;84(6):4033-42.
2003: Marco V Bayas; Klaus Schulten; Deborah E Leckband
Forced detachment of the CD2-CD58 complex.
Biophysical journal 2003;84(4):2223-33.
2002: Boru Zhu; Elizabeth A Davies; Philip van der Merwe; Tammy Calvert; Deborah E Leckband
Direct measurements of heterotypic adhesion between the cell surface proteins CD2 and CD48.
Biochemistry 2002;41(40):12163-70.
2002: Deborah E Leckband
The structure of the C-cadherin ectodomain resolved.
Structure (London, England : 1993) 2002;10(6):739-40.
2001: B Zhu; T Eurell; Rudiyanto Gunawan; Deborah E Leckband
Chain-length dependence of the protein and cell resistance of oligo(ethylene glycol)-terminated self-assembled monolayers on gold.
Journal of biomedical materials research 2001;56(3):406-16.
2001: Deborah E Leckband
Force as a probe of membrane protein structure and function.
Current opinion in structural biology 2001;11(4):433-9.
2001: S Sivasankar; BM Gumbiner; Deborah E Leckband
Direct measurements of multiple adhesive alignments and unbinding trajectories between cadherin extracellular domains.
Biophysical journal 2001;80(4):1758-68.
2001: R A Vijayendran; Deborah E Leckband
A quantitative assessment of heterogeneity for surface-immobilized proteins.
Analytical chemistry 2001;73(3):471-80.
2000: Deborah E Leckband; S Sivasankar
Mechanism of homophilic cadherin adhesion.
Current opinion in cell biology 2000;12(5):587-92.
2000: N V Efremova; Bruce Bondurant; David F O'Brien; Deborah E Leckband
Measurements of interbilayer forces and protein adsorption on uncharged lipid bilayers displaying poly(ethylene glycol) chains.
Biochemistry 2000;39(12):3441-51.
2000: Deborah E Leckband; Tonya L Kuhl; H K Wang; W Müller; J Herron; H Ringsdorf
Force probe measurements of antibody-antigen interactions.
Methods (San Diego, Calif.) 2000;20(3):329-40.
2000: Deborah E Leckband
Measuring the forces that control protein interactions.
Annual review of biophysics and biomolecular structure 2000;29():1-26.
1999: R A Vijayendran; Frances S Ligler; Deborah E Leckband
A computational reaction-diffusion model for the analysis of transport-limited kinetics.
Analytical chemistry 1999;71(23):5405-12.
1999: S Sivasankar; W Brieher; N Lavrik; BM Gumbiner; Deborah E Leckband
Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11820-4.
1999: Deborah E Leckband; S Sheth; A Halperin
Grafted poly(ethylene oxide) brushes as nonfouling surface coatings.
Journal of biomaterials science. Polymer edition 1999;10(10):1125-47.
1998: Tonya L Kuhl; Jaroslaw Majewski; Wong Wong; S Steinberg; Deborah E Leckband; Jacob Israelachvili; GS Smith
A neutron reflectivity study of polymer-modified phospholipid monolayers at the solid-solution interface: polyethylene glycol-lipids on silane-modified substrates.
Biophysical journal 1998;75(5):2352-62.
1998: S Sivasankar; Shankar Subramaniam; Deborah E Leckband
Direct molecular level measurements of the electrostatic properties of a protein surface.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):12961-6.
1998: Z W Yu; T L Calvert; Deborah E Leckband
Molecular forces between membranes displaying neutral glycosphingolipids: evidence for carbohydrate attraction.
Biochemistry 1998;37(6):1540-50.
1997: S R Sheth; Deborah E Leckband
Measurements of attractive forces between proteins and end-grafted poly(ethylene glycol) chains.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8399-404.
1997: Deborah E Leckband
The influence of protein and interfacial structure on the self-assembly of oriented protein arrays.
Advances in biophysics 1997;34():173-90.
1995: Deborah E Leckband; Tonya L Kuhl; H K Wang; J Herron; W Müller; H Ringsdorf
4-4-20 anti-fluorescyl IgG Fab' recognition of membrane bound hapten: direct evidence for the role of protein and interfacial structure.
Biochemistry 1995;34(36):11467-78.
1995: Deborah E Leckband; W Müller; F J Schmitt; H Ringsdorf
Molecular mechanisms determining the strength of receptor-mediated intermembrane adhesion.
Biophysical journal 1995;69(3):1162-9.
1995: Deborah E Leckband
The surface apparatus--a tool for probing molecular protein interactions.
Nature 1995;376(6541):617-8.
1995: G Balgi; Deborah E Leckband; Johannes Nitsche
Transport effects on the kinetics of protein-surface binding.
Biophysical journal 1995;68(6):2251-60.
1995: Deborah E Leckband
Using the soft touch on cell surfaces.
Biophysical journal 1995;68(6):2215-6.
1994: S Chiruvolu; S Walker; Jacob Israelachvili; F J Schmitt; Deborah E Leckband; Joseph A Zasadzinski
Higher order self-assembly of vesicles by site-specific binding.
Science (New York, N.Y.) 1994;264(5166):1753-6.
1994: Tonya L Kuhl; Deborah E Leckband; D D Lasic; Jacob Israelachvili
Modulation of interaction forces between bilayers exposing short-chained ethylene oxide headgroups.
Biophysical journal 1994;66(5):1479-88.
1994: Deborah E Leckband; F J Schmitt; Jacob Israelachvili; W Knoll
Direct force measurements of specific and nonspecific protein interactions.
Biochemistry 1994;33(15):4611-24.
1993: Deborah E Leckband; Jacob Israelachvili
Molecular basis of protein function as determined by direct force measurements.
Enzyme and microbial technology 1993;15(6):450-9.
1993: Deborah E Leckband; C A Helm; Jacob Israelachvili
Role of calcium in the adhesion and fusion of bilayers.
Biochemistry 1993;32(4):1127-40.
1992: Deborah E Leckband; Jacob Israelachvili; F J Schmitt; W Knoll
Long-range attraction and molecular rearrangements in receptor-ligand interactions.
Science (New York, N.Y.) 1992;255(5050):1419-21.