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Stewart Lecker

Research Profile

Chemicals & Drugs

Disorders

Muscular Atrophy

Anatomy

Living Beings

Physiology

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Publications

TOP 3
Sonisha A Warren; Monte S Willis; Huadong Zeng; Laura E Briggs; Eileen I Chang; Joyce Chuang; Stewart H Lecker; Moyi Li; Julie Maupin-Furlowe; Julie R McMullen; Richard L Moss; Francis G Spinale; Maurice S Swanson; Ryota Terada; Hideko Kasahara
Myosin light chain phosphorylation is critical for adaptation to cardiac stress.
Stewart H Lecker; P Christian Schulze; Alexandra Zavin; Jacob Joseph; Kelly Allsup; Ross Arena; Peirang Cao; Karla M Daniels; Daniel E Forman
Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure.
Stewart H Lecker; William E Mitch
Proteolysis by the ubiquitin-proteasome system and kidney disease.

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All Publications

2012: Sonisha A Warren; Monte S Willis; Huadong Zeng; Laura E Briggs; Eileen I Chang; Joyce Chuang; Stewart H Lecker; Moyi Li; Julie Maupin-Furlowe; Julie R McMullen; Richard L Moss; Francis G Spinale; Maurice S Swanson; Ryota Terada; Hideko Kasahara
Myosin light chain phosphorylation is critical for adaptation to cardiac stress.
Circulation 2012;126(22):2575-88.
2012: Stewart H Lecker; P Christian Schulze; Alexandra Zavin; Jacob Joseph; Kelly Allsup; Ross Arena; Peirang Cao; Karla M Daniels; Daniel E Forman
Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure.
Circulation. Heart failure 2012;5(6):812-8.
2011: Stewart H Lecker; William E Mitch
Proteolysis by the ubiquitin-proteasome system and kidney disease.
Journal of the American Society of Nephrology : JASN 2011;22(5):821-4.
2011: Simon S Wing; Stewart H Lecker; R Thomas Jagoe
Proteolysis in illness-associated skeletal muscle atrophy: from pathways to networks.
Critical reviews in clinical laboratory sciences 2011;48(2):49-70.
2010: Giulia Mearini; Christina Gedicke; Saskia Schlossarek; Christian C Witt; Elisabeth Krämer; Peirang Cao; Marcelo D Gomes; Stewart H Lecker; Siegfried Labeit; Monte Willis; Thomas Eschenhagen; Lucie Carrier
Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms.
Cardiovascular research 2010;85(2):357-66.
2009: Stewart H Lecker
Given the science on malnutrition, how does the clinician respond? Practical lessons for and application to the dialysis patient.
Clinical journal of the American Society of Nephrology : CJASN 2009;4 Suppl 1():S64-70.
2009: Dawit A P Gonçalves; Eduardo C Lira; Amanda Baviera; Peirang Cao; Neusa M Zanon; Zoltan Arany; Nathalie Bedard; Preeti Tanksale; Simon S Wing; Stewart H Lecker; Isis C Kettelhut; Luiz Carlos C Navegantes
Mechanisms involved in 3',5'-cyclic adenosine monophosphate-mediated inhibition of the ubiquitin-proteasome system in skeletal muscle.
Endocrinology 2009;150(12):5395-404.
2009: Mark S Miller; Peter VanBuren; Martin M LeWinter; Stewart H Lecker; Donald E Selby; Bradley M Palmer; David Wayne Maughan; Philip A Ades; Michael J Toth
Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and function.
Circulation. Heart failure 2009;2(6):700-6.
2009: Peirang Cao; Jun-Ichi Hanai; Preeti Tanksale; Shintaro Imamura; Vikas P Sukhatme; Stewart H Lecker
Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(9):2844-54.
2008: Vipul C Chitalia; Rebecca L Foy; Markus Bachschmid; Liling Zeng; Maria V Panchenko; Mina I Zhou; Ajit Bharti; David C Seldin; Stewart H Lecker; Isabel Dominguez; Herbert T Cohen
Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL.
Nature cell biology 2008;10(10):1208-16.
2008: Ira J Smith; Stewart H Lecker; Per-Olof Hasselgren
Calpain activity and muscle wasting in sepsis.
American journal of physiology. Endocrinology and metabolism 2008;295(4):E762-71.
2008: Catherine Buettner; Stewart H Lecker
Molecular basis for statin-induced muscle toxicity: implications and possibilities.
Pharmacogenomics 2008;9(8):1133-42.
2008: Gabor Bodonyi-Kovacs; Stewart H Lecker
Electrolyte-free water clearance: a key to the diagnosis of hypernatremia in resolving acute renal failure.
Clinical and experimental nephrology 2008;12(1):74-8.
2007: Jinghui Zhao; Jeffrey J Brault; Andreas Schild; Peirang Cao; Marco Sandri; Stefano Schiaffino; Stewart H Lecker; Alfred L Goldberg
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.
Cell metabolism 2007;6(6):472-83.
2007: Jun-ichi Hanai; Peirang Cao; Preeti Tanksale; Shintaro Imamura; Eriko Koshimizu; Jinghui Zhao; Shuji Kishi; Michiaki Yamashita; Paul S Phillips; Vikas P Sukhatme; Stewart H Lecker
The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity.
The Journal of clinical investigation 2007;117(12):3940-51.
2007: Yuval Bdolah; Adam Segal; Preeti Tanksale; S Ananth Karumanchi; Stewart H Lecker
Atrophy-related ubiquitin ligases atrogin-1 and MuRF-1 are associated with uterine smooth muscle involution in the postpartum period.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;292(2):R971-6.
2007: Jennifer M Sacheck; JP Hyatt; Anna Raffaello; R Thomas Jagoe; Roland R Roy; V Reggie Edgerton; Stewart H Lecker; Alfred L Goldberg
Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(1):140-55.
2006: Marco Sandri; Jiandie Lin; Christoph Handschin; Wenli Yang; Zoltan Arany; Stewart H Lecker; Alfred L Goldberg; Bruce M Spiegelman
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16260-5.
2006: Stewart H Lecker; Alfred L Goldberg; William E Mitch
Protein degradation by the ubiquitin-proteasome pathway in normal and disease states.
Journal of the American Society of Nephrology : JASN 2006;17(7):1807-19.
2005: Pei Rang Cao; Hannah J Kim; Stewart H Lecker
Ubiquitin-protein ligases in muscle wasting.
The international journal of biochemistry & cell biology 2005;37(10):2088-97.
2005: Carsten Skurk; Yasuhiro Izumiya; Henrike Maatz; Peter Razeghi; Ichiro Shiojima; Marco Sandri; Kaori Sato; Ling Zeng; Stephan Schiekofer; David R Pimentel; Stewart H Lecker; Heinrich Taegtmeyer; Alfred L Goldberg; Kenneth Walsh
The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling.
The Journal of biological chemistry 2005;280(21):20814-23.
2004: Marco Sandri; Claudia Sandri; Alex Gilbert; Carsten Skurk; Elisa Calabria; Anne Picard; Kenneth Walsh; Stefano Schiaffino; Stewart H Lecker; Alfred L Goldberg
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.
Cell 2004;117(3):399-412.
2004: Stewart H Lecker; R Thomas Jagoe; Alexander Gilbert; Marcelo Gomes; Vickie E Baracos; James Bailey; S Russ Price; William E Mitch; Alfred L Goldberg
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(1):39-51.
2003: Yi-Ping Li; Stewart H Lecker; Yuling Chen; Ian D Waddell; Alfred L Goldberg; Michael B Reid
TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220k.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):1048-57.
2003: Stewart H Lecker
Ubiquitin-protein ligases in muscle wasting: multiple parallel pathways?
Current opinion in clinical nutrition and metabolic care 2003;6(3):271-5.
2002: Stewart H Lecker; Alfred L Goldberg
Slowing muscle atrophy: putting the brakes on protein breakdown.
The Journal of physiology 2002;545(Pt 3):729.
2002: R Thomas Jagoe; Stewart H Lecker; Marcelo Gomes; Alfred L Goldberg
Patterns of gene expression in atrophying skeletal muscles: response to food deprivation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(13):1697-712.
2001: M D Gomes; Stewart H Lecker; R Thomas Jagoe; Amiel Navon; Alfred L Goldberg
Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(25):14440-5.
2001: Yong Tae Kwon; Zanxian Xia; Ilia V Davydov; Stewart H Lecker; Alexander Varshavsky
Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.
Molecular and cellular biology 2001;21(23):8007-21.
2000: Y Gao; Stewart H Lecker; M J Post; AJ Hietaranta; Jianyi Li; R Volk; M Li; K Sato; Ashok K Saluja; Michael L Steer; Alfred L Goldberg; Michael Simons
Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha degradation by a naturally occurring antibacterial peptide.
The Journal of clinical investigation 2000;106(3):439-48.
2000: E Tarcsa; Grazyna Szymanska; Stewart H Lecker; C M O'Connor; Alfred L Goldberg
Ca2+-free calmodulin and calmodulin damaged by in vitro aging are selectively degraded by 26 S proteasomes without ubiquitination.
The Journal of biological chemistry 2000;275(27):20295-301.
1999: Stewart H Lecker; Vered Solomon; S Russ Price; Yong Tae Kwon; William E Mitch; Alfred L Goldberg
Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats.
The Journal of clinical investigation 1999;104(10):1411-20.
1999: Thomas Benzing; R Brandes; Lorenz Sellin; Bernhard Schermer; Stewart H Lecker; Gerd Walz; Eunjoon Kim
Upregulation of RGS7 may contribute to tumor necrosis factor-induced changes in central nervous function.
Nature medicine 1999;5(8):913-8.
1999: Stewart H Lecker; Vered Solomon; William E Mitch; Alfred L Goldberg
Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states.
The Journal of nutrition 1999;129(1S Suppl):227S-237S.
1998: Vered Solomon; Stewart H Lecker; Alfred L Goldberg
The N-end rule pathway catalyzes a major fraction of the protein degradation in skeletal muscle.
The Journal of biological chemistry 1998;273(39):25216-22.