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Guy Leclercq
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Chemicals & Drugs
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17
Laïos, Ioanna
16
Laurent, Guy
11
Nonclercq, Denis
11
Jacquot, Yves
10
Cleeren, Anny
8
Journé, Fabrice
8
Legros, N
8
Lacroix, Marc
7
Seo, Hye-Sook
7
Toillon, Robert-Alain
7
El Khissiin, A
6
Larsimont, Denis
6
Maaroufi, Y
5
Xicluna, Alain
4
Lacroix, Marc
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All Publications
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2009: Agouridas Vangelis; Magnier Emmanuel; Blazejewski Jean-Claude; Laïos Ioanna; Cleeren Anny; Nonclercq Denis; Laurent Guy; Leclercq Guy
Effect of fluorination on the pharmacological profile of 11beta isomers of fulvestrant in breast carcinoma cells.
Journal of medicinal chemistry 2009;52(3):883-7.
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2008: Gallo Dominique; Jacquot Yves; Laurent Guy; Leclercq Guy
Calmodulin, a regulatory partner of the estrogen receptor alpha in breast cancer cells.
Molecular and cellular endocrinology 2008;291(1-2):20-6.
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2008: Journé Fabrice; Body Jean-Jacques; Leclercq Guy; Laurent Guy
Hormone therapy for breast cancer, with an emphasis on the pure antiestrogen fulvestrant: mode of action, antitumor efficacy and effects on bone health.
Expert opinion on drug safety 2008;7(3):241-58.
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2008: Gallo Dominique; Haddad Iman; Duvillier Hugues; Jacquemotte Françoise; Laïos Ioanna; Laurent Guy; Jacquot Yves; Vinh Joëlle; Leclercq Guy
Trophic effect in MCF-7 cells of ERalpha17p, a peptide corresponding to a platform regulatory motif of the estrogen receptor alpha--underlying mechanisms.
The Journal of steroid biochemistry and molecular biology 2008;109(1-2):138-49.
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2008: Agouridas Vangelis; Blazejewski Jean-Claude; Cleeren Anny; Laïos Ioanna; Leclercq Guy; Magnier Emmanuel
Fluorous tolerance of the estrogen receptor alpha as probed by 11-polyfluoroalkylestradiol derivatives.
Steroids 2008;73(3):320-7.
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2008: Gallo Dominique; Haddad Iman; Laurent Guy; Vinh Joëlle; Jacquemotte Françoise; Jacquot Yves; Leclercq Guy
Regulatory function of the P295-T311 motif of the estrogen receptor alpha - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses?
Nuclear receptor signaling 2008;6():e007.
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2007: Laïos Ioanna; Cleeren Anny; Leclercq Guy; Nonclercq Denis; Laurent Guy; Schlenk Miriam; Wellner Anja; Gust Ronald
Effects of (R,S)/(S,R)-4,5-bis(2-chloro-4-hydroxyphenyl)-2-imidazolines and (R,S)/(S,R)-2,3-bis(2-chloro-4-hydroxyphenyl)piperazines on estrogen receptor alpha level and transcriptional activity in MCF-7 cells.
Biochemical pharmacology 2007;74(7):1029-38.
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2007: Nonclercq Denis; Journé Fabrice; Laïos Ioanna; Chaboteaux Carole; Toillon Robert-Alain; Leclercq Guy; Laurent Guy
Effect of nuclear export inhibition on estrogen receptor regulation in breast cancer cells.
Journal of molecular endocrinology 2007;39(2):105-18.
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2007: Jacquot Yves; Gallo Dominique; Leclercq Guy
Estrogen receptor alpha--identification by a modeling approach of a potential polyproline II recognizing domain within the AF-2 region of the receptor that would play a role of prime importance in its mechanism of action.
The Journal of steroid biochemistry and molecular biology 2007;104(1-2):1-10.
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2007: Toillon Robert-Alain; Magné Nicolas; Laïos Ioanna; Castadot Pierre; Kinnaert Eric; Van Houtte Paul; Desmedt Christine; Leclercq Guy; Lacroix Marc
Estrogens decrease gamma-ray-induced senescence and maintain cell cycle progression in breast cancer cells independently of p53.
International journal of radiation oncology, biology, physics 2007;67(4):1187-200.
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2007: Gallo Dominique; Jacquemotte Françoise; Cleeren Anny; Laïos Ioanna; Hadiy Samira; Rowlands Martin G; Caille Olivier; Nonclercq Denis; Laurent Guy; Jacquot Yves; Leclercq Guy
Calmodulin-independent, agonistic properties of a peptide containing the calmodulin binding site of estrogen receptor alpha.
Molecular and cellular endocrinology 2007;268(1-2):37-49.
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2007: Jacquot Yves; Laïos Ioanna; Cleeren Anny; Nonclercq Denis; Bermont Laurent; Refouvelet Bernard; Boubekeur Kamal; Xicluna Alain; Leclercq Guy; Laurent Guy
Synthesis, structure, and estrogenic activity of 4-amino-3-(2-methylbenzyl)coumarins on human breast carcinoma cells.
Bioorganic & medicinal chemistry 2007;15(6):2269-82.
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2006: Agouridas Vangelis; Laïos Ioanna; Cleeren Anny; Kizilian Elyane; Magnier Emmanuel; Blazejewski Jean-Claude; Leclercq Guy
Loss of antagonistic activity of tamoxifen by replacement of one N-methyl of its side chain by fluorinated residues.
Bioorganic & medicinal chemistry 2006;14(22):7531-8.
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2006: Seo Hye-Sook; DeNardo David G; Jacquot Yves; Laïos Ioanna; Vidal Doris Salazar; Zambrana Carmen Rojas; Leclercq Guy; Brown Powel H
Stimulatory effect of genistein and apigenin on the growth of breast cancer cells correlates with their ability to activate ER alpha.
Breast cancer research and treatment 2006;99(2):121-34.
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2006: Lacroix Marc; Toillon Robert-Alain; Leclercq Guy
p53 and breast cancer, an update.
Endocrine-related cancer 2006;13(2):293-325.
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2006: Leclercq Guy; Lacroix Marc; Laïos Ioanna; Laurent Guy
Estrogen receptor alpha: impact of ligands on intracellular shuttling and turnover rate in breast cancer cells.
Current cancer drug targets 2006;6(1):39-64.
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2005: Toillon R A; Magné N; Laïos I; Lacroix M; Duvillier H; Lagneaux L; Devriendt D; Van Houtte P; Leclercq G
Interaction between estrogen receptor alpha, ionizing radiation and (anti-) estrogens in breast cancer cells.
Breast cancer research and treatment 2005;93(3):207-15.
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2005: Laïos Ioanna; Journé Fabrice; Nonclercq Denis; Vidal Doris Salazar; Toillon Robert-Alain; Laurent Guy; Leclercq Guy
Role of the proteasome in the regulation of estrogen receptor alpha turnover and function in MCF-7 breast carcinoma cells.
The Journal of steroid biochemistry and molecular biology 2005;94(4):347-59.
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2005: Lacroix Marc; Leclercq Guy
The "portrait" of hereditary breast cancer.
Breast cancer research and treatment 2005;89(3):297-304.
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2004: Laïos I; Cleeren A; Xicluna A; Jacquot Y; Leclercq G
[Lack of implication of estrogen receptors in ovarian toxicity induced by psoralens]
Annales de dermatologie et de vénéréologie 2004;131(11):994-6.
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2004: Nonclercq Denis; Journé Fabrice; Body Jean-Jacques; Leclercq Guy; Laurent Guy
Ligand-independent and agonist-mediated degradation of estrogen receptor-alpha in breast carcinoma cells: evidence for distinct degradative pathways.
Molecular and cellular endocrinology 2004;227(1-2):53-65.
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2004: Jaouen Gérard; Top Siden; Vessières Anne; Leclercq G; McGlinchey Michael J
The first organometallic selective estrogen receptor modulators (SERMs) and their relevance to breast cancer.
Current medicinal chemistry 2004;11(18):2505-17.
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2004: Lacroix M; Toillon R-A; Leclercq G
Stable 'portrait' of breast tumors during progression: data from biology, pathology and genetics.
Endocrine-related cancer 2004;11(3):497-522.
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2004: Journé Fabrice; Body Jean-Jacques; Leclercq Guy; Nonclercq Denis; Laurent Guy
Estrogen responsiveness of IBEP-2, a new human cell line derived from breast carcinoma.
Breast cancer research and treatment 2004;86(1):39-53.
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2004: Lacroix M; Leclercq G
About GATA3, HNF3A, and XBP1, three genes co-expressed with the oestrogen receptor-alpha gene (ESR1) in breast cancer.
Molecular and cellular endocrinology 2004;219(1-2):1-7.
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2004: Lacroix Marc; Leclercq Guy
Relevance of breast cancer cell lines as models for breast tumours: an update.
Breast cancer research and treatment 2004;83(3):249-89.
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2003: Laïos Ioanna; Journe Fabrice; Laurent Guy; Nonclercq Denis; Toillon Robert-Alain; Seo Hye-Sook; Leclercq Guy
Mechanisms governing the accumulation of estrogen receptor alpha in MCF-7 breast cancer cells treated with hydroxytamoxifen and related antiestrogens.
The Journal of steroid biochemistry and molecular biology 2003;87(2-3):207-21.
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2003: Top Siden; Vessières Anne; Leclercq Guy; Quivy Jacques; Tang J; Vaissermann J; Huché Michel; Jaouen Gérard
Synthesis, biochemical properties and molecular modelling studies of organometallic specific estrogen receptor modulators (SERMs), the ferrocifens and hydroxyferrocifens: evidence for an antiproliferative effect of hydroxyferrocifens on both hormone-dependent and hormone-independent breast cancer cell lines.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(21):5223-36.
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2003: Top Siden; Kaloun El Bachir; Vessières Anne; Leclercq Guy; Laïos Ioanna; Ourevitch Michèle; Deuschel Christine; McGlinchey Michael J; Jaouen Gérard
Tamoxifen derivatives for delivery of the antitumoral (DACH)Pt group: selective synthesis by McMurry coupling, and biochemical behaviour.
Chembiochem : a European journal of chemical biology 2003;4(8):754-61.
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2003: Jacquot Y; Rojas C; Refouvelet B; Robert J F; Leclercq G; Xicluna A
Recent advances in the development of phytoestrogens and derivatives: an update of the promising perspectives in the prevention of postmenopausal diseases.
Mini reviews in medicinal chemistry 2003;3(5):387-400.
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2003: Seo Hye-Sook; Journé Fabrice; Larsimont Denis; Sotiriou Christos; Leclercq Guy
Decrease of estrogen receptor expression and associated ERE-dependent transcription in MCF-7 breast cancer cells after oligomycin treatment.
Steroids 2003;68(3):257-69.
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2003: Blazejewski Jean-Claude; Wilmshurst Martin P; Popkin Matthew D; Wakselman Claude; Laurent Guy; Nonclercq Denis; Cleeren Anny; Ma Yan; Seo Hye-Sook; Leclercq Guy
Synthesis, characterization and biological evaluation of 7 alpha-perfluoroalkylestradiol derivatives.
Bioorganic & medicinal chemistry 2003;11(3):335-45.
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2002: Jacquot Y; Refouvelet B; Bermont L; Adessi G L; Leclercq G; Xicluna A
Synthesis and cytotoxic activity of new 2,4-diaryl-4H,5H-pyrano[3,2-c]benzopyran-5-ones on MCF-7 cells.
Die Pharmazie 2002;57(4):233-7.
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2002: Leclercq Guy
Molecular forms of the estrogen receptor in breast cancer.
The Journal of steroid biochemistry and molecular biology 2002;80(3):259-72.
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2002: Jacquot Yves; Cleeren Anny; Laios Ioanna; Yan Ma; Boulahdour Athem; Bermont Laurent; Refouvelet Bernard; Adessi Gérard; Leclercq Guy; Xicluna Alain
Pharmacological profile of 6,12-dihydro-3-methoxy-1-benzopyrano[3,4-b] [1,4]benzothiazin-6-one, a novel human estrogen receptor agonist.
Biological & pharmaceutical bulletin 2002;25(3):335-41.
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2002: Seo Hye Sook; Leclercq Guy
Evaluation of potential implication of membrane estrogen binding sites on ERE-dependent transcriptional activity and intracellular estrogen receptor-alpha regulation in MCF-7 breast cancer cells.
The Journal of steroid biochemistry and molecular biology 2002;80(1):109-23.
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2001: Lacroix M; Querton G; Hennebert P; Larsimont D; Leclercq G
Estrogen receptor analysis in primary breast tumors by ligand-binding assay, immunocytochemical assay, and northern blot: a comparison.
Breast cancer research and treatment 2001;67(3):263-71.
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2001: Lespagnard L; Gancberg D; Maaroufi Y; Leclercq G; Larsimont D; Verhest A
In situ amplification of oestrogen receptor alpha mRNA in breast cancer cell lines and tumours.
Molecular pathology : MP 2001;54(3):197-9.
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2001: Devriendt D; Ma Y; Kinnaert E; Journe F; Seo H S; Van Houtte P; Leclercq G
Effect of low dose irradiation on estrogen receptor level in MCF-7 breast cancer cells.
International journal of cancer. Journal international du cancer 2001;96(1):32-40.
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2000: El Khissiin A; Journé F; Laïos I; Seo H S; Leclercq G
Evidence of an estrogen receptor form devoid of estrogen binding ability in MCF-7 cells.
Steroids 2000;65(12):903-13.
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2000: Brohée R; Nonclercq D; Journé D N; Toubeau G; Falmagne P; Leclercq G; Heuson-Stiennon J A; Laurent G
Demonstration of estrogen receptors and of estrogen responsiveness in the HKT-1097 cell line derived from diethylstilbestrol-induced kidney tumors.
In vitro cellular & developmental biology. Animal 2000;36(10):640-9.
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2000: Seo H S; Larsimont D; Ma Y; Laios I; Leclercq G
Regulation of estrogen receptor levels by ligand-induced release of compound(s) in MCF-7 cells.
Molecular and cellular endocrinology 2000;164(1-2):19-29.
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2000: Maaroufi Y; Lacroix M; Lespagnard L; Journé F; Larsimont D; Leclercq G
Estrogen receptor of primary breast cancers: evidence for intracellular proteolysis.
Breast cancer research : BCR 2000;2(6):444-54.
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1999: Lespagnard L; Gancberg D; Rouas G; Leclercq G; de Saint-Aubain Somerhausen N; Di Leo A; Piccart M; Verhest A; Larsimont D
Tumor-infiltrating dendritic cells in adenocarcinomas of the breast: a study of 143 neoplasms with a correlation to usual prognostic factors and to clinical outcome.
International journal of cancer. Journal international du cancer 1999;84(3):309-14.
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1999: El Khissiin A; Leclercq G
Implication of proteasome in estrogen receptor degradation.
FEBS letters 1999;448(1):160-6.
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1998: Seo H S; Larsimont D; Querton G; El Khissiin A; Laios I; Legros N; Leclercq G
Estrogenic and anti-estrogenic regulation of estrogen receptor in MCF-7 breast-cancer cells: comparison of immunocytochemical data with biochemical measurements.
International journal of cancer. Journal international du cancer 1998;78(6):760-5.
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1998: El khissiin A; Leclercq G
Exchange of bound estrogens and antiestrogens in MCF-7 cells: evidence for ligand-induced stable configurations of the estrogen receptor.
Steroids 1998;63(11):565-74.
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1998: Maaroufi Y; Quivy J; Trivedi S; Gilot N; Leclercq G
4-iodotamoxifen aziridine, a new affinity labeling agent for the rapid detection of estrogen receptor isoforms.
The Journal of steroid biochemistry and molecular biology 1998;67(2):95-104.
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1998: Piccart M J; Trivedi S; Maaroufi Y; Debbaudt A; Veenstra S; Leclercq G
Evolution towards hormone independence of the MXT mouse mammary tumor is associated with a gradual change in its estrogen receptor molecular polymorphism.
Cancer biochemistry biophysics 1998;16(1-2):169-82.
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1998: Jin L; Legros N; Leclercq G; Hardcastle I R; Jarman M
Length increase of the side chain of idoxifene does not improve its antagonistic potency in breast-cancer cell lines.
Cancer chemotherapy and pharmacology 1998;41(4):339-42.
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1997: Borras M; Lacroix M; Legros N; Leclercq G
Estrogen receptor-negative/progesterone receptor-positive Evsa-T mammary tumor cells: a model for assessing the biological property of this peculiar phenotype of breast cancers.
Cancer letters 1997;120(1):23-30.
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1997: Maaroufi Y; Ben Hardouze A; Leclercq G
Decrease of hormone binding capacity of estrogen receptor by calcium.
Journal of receptor and signal transduction research 1997;17(6):833-53.
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1997: El Khissiin A; Cleeren A; Borràs M; Leclercq G
Protein synthesis is not implicated in the ligand-dependent activation of the estrogen receptor in MCF-7 cells.
The Journal of steroid biochemistry and molecular biology 1997;62(4):269-76.
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1997: Rowlands M G; Grimshaw R; Jarman M; Bouhoute A; Leclercq G
Antagonism of estrogen receptor and calmodulin association by antiestrogens is not dependent on an interaction with calmodulin.
Biochemical pharmacology 1997;53(2):241-4.
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1997: Legros N; Jin L; Leclercq G
Tamoxifen-induced estrogen receptor up-regulation in mammary tumor cells is not related to growth inhibition.
Cancer chemotherapy and pharmacology 1997;39(4):380-2.
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1996: Quivy J; Leclercq G; Deblaton M; Henrot P; Velings N; Norberg B; Evrard G; Zeicher M
Synthesis, structure and biological properties of Z-17alpha-(2-iodovinyl)-11beta-chloromethyl estradiol-17beta (Z-CMIV), a high affinity ligand for the characterization of estrogen receptor-positive tumors.
The Journal of steroid biochemistry and molecular biology 1996;59(1):103-17.
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1996: Borrás M; Laios I; el Khissiin A; Seo H S; Lempereur F; Legros N; Leclercq G
Estrogenic and antiestrogenic regulation of the half-life of covalently labeled estrogen receptor in MCF-7 breast cancer cells.
The Journal of steroid biochemistry and molecular biology 1996;57(3-4):203-13.
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1996: Trivedi S; Piccart M; Muquardt C; Gilot N; Hadiy S; Patel D; Leclercq G
Tamoxifen aziridine labeling of the estrogen receptor-potential utility in detecting biologically aggressive breast tumors.
Breast cancer research and treatment 1996;40(3):231-41.
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1995: Maaroufi Y; Trivedi S; Leclercq G
Major molecular weight heterogeneity of estrogen receptor from breast cancer is not related to neoplasia.
Cancer biochemistry biophysics 1995;15(2):67-78.
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1995: Jin L; Borrás M; Lacroix M; Legros N; Leclercq G
Antiestrogenic activity of two 11 beta-estradiol derivatives on MCF-7 breast cancer cells.
Steroids 1995;60(8):512-8.
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1994: Borras M; Jin L; Bouhoute A; Legros N; Leclercq G
Evaluation of estrogen receptor, antiestrogen binding sites and calmodulin for antiestrogen resistance of two clones derived from the MCF-7 breast cancer cell line.
Biochemical pharmacology 1994;48(11):2015-24.
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1994: Borrás M; Hardy L; Lempereur F; el Khissiin A H; Legros N; Gol-Winkler R; Leclercq G
Estradiol-induced down-regulation of estrogen receptor. Effect of various modulators of protein synthesis and expression.
The Journal of steroid biochemistry and molecular biology 1994;48(4):325-36.
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1994: Maaroufi Y; Leclercq G
Importance of A/B and C domains of the estrogen receptor for its adsorption to hydroxylapatite.
The Journal of steroid biochemistry and molecular biology 1994;48(1):155-63.
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