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Georges Leclercq

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Inge Van de Walle; Bart Vandekerckhove; Els Waegemans; Tao Wang; Jelle De Medts; Magda De Smedt; Greet De Smet; Thomas Gridley; Tessa Kerre; Ute Koch; Georges Leclercq; Jean Plum; Freddy Radtke; Sylvia Snauwaert; Tom Taghon
Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.
Tina Van Den Broeck; Bart Vandekerckhove; Maarten Delforche; Tessa C C Kerre; Jean Plum; Tom Taghon; Sylvie Taveirne; Els Van Ammel; Georges Leclercq
Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells.
Sylvia Snauwaert; Tom Taghon; Kris Thielemans; Yasmine Van Caeneghem; Zwi N Berneman; Glenn Goetgeluk; Tessa C C Kerre; Georges Leclercq; Jan Philippé; Jean Plum; Stijn Vanhee; Imke Velghe; Greet Verstichel; Bart Vandekerckhove
RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia.

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All Publications

2013: Inge Van de Walle; Bart Vandekerckhove; Els Waegemans; Tao Wang; Jelle De Medts; Magda De Smedt; Greet De Smet; Thomas Gridley; Tessa Kerre; Ute Koch; Georges Leclercq; Jean Plum; Freddy Radtke; Sylvia Snauwaert; Tom Taghon
Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.
The Journal of experimental medicine 2013;210(4):683-97.
2013: Tina Van Den Broeck; Bart Vandekerckhove; Maarten Delforche; Tessa C C Kerre; Jean Plum; Tom Taghon; Sylvie Taveirne; Els Van Ammel; Georges Leclercq
Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(5):1982-90.
2012: Sylvia Snauwaert; Tom Taghon; Kris Thielemans; Yasmine Van Caeneghem; Zwi N Berneman; Glenn Goetgeluk; Tessa C C Kerre; Georges Leclercq; Jan Philippé; Jean Plum; Stijn Vanhee; Imke Velghe; Greet Verstichel; Bart Vandekerckhove
RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia.
Haematologica 2012;97(10):1539-47.
2012: Tom Van Belle; Xiao-Qing Wei; Tom Boonefaes; H Dooms; Georges Leclercq; Johan Grooten
IL-15 augments TCR-induced CD4+ T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4+ T cells.
PloS one 2012;7(9):e45299.
2011: Veerle De Colvenaer; Magda De Smedt; Maarten Delforche; Jean Plum; Tom Taghon; Sylvie Taveirne; Bart Vandekerckhove; Louis Boon; Georges Leclercq
CD27-deficient mice show normal NK-cell differentiation but impaired function upon stimulation.
Immunology and cell biology 2011;89(7):803-11.
2011: Sylvie Taveirne; Els Van Ammel; Tina Van Den Broeck; Bart Vandekerckhove; Clare L Bennett; Björn E Clausen; Veerle De Colvenaer; Daniel H Kaplan; Jean Plum; Tom Taghon; Georges Leclercq
Langerhans cells are not required for epidermal Vgamma3 T cell homeostasis and function.
Journal of leukocyte biology 2011;90(1):61-8.
2011: Magda De Smedt; Georges Leclercq; Bart Vandekerckhove; Tessa Kerre; Tom Taghon; Jean Plum
T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells.
Haematologica 2011;96(5):646-54.
2011: Inge Van de Walle; Greet De Smet; Martina Gärtner; Magda De Smedt; Els Waegemans; Bart Vandekerckhove; Georges Leclercq; Jean Plum; Jon C Aster; Irwin D Bernstein; Cynthia J Guidos; Bruno Kyewski; Tom Taghon
Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.
Blood 2011;117(17):4449-59.
2011: Bart Vandekerckhove; Stijn Vanhee; Stefanie Van Coppernolle; Sylvia Snauwaert; Imke Velghe; Tom Taghon; Georges Leclercq; Tessa C C Kerre; Jean Plum
In vitro generation of immune cells from pluripotent stem cells.
Frontiers in bioscience : a journal and virtual library 2011;16():1488-504.
2009: Stefanie Van Coppernolle; Greet Verstichel; Frank Timmermans; Imke Velghe; David Vermijlen; Magda De Smedt; Georges Leclercq; Jean Plum; Tom Taghon; Bart Vandekerckhove; Tessa C C Kerre
Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):4859-70.
2009: Frank Timmermans; Imke Velghe; Lieve Vanwalleghem; Magda De Smedt; Stefanie Van Coppernolle; Tom Taghon; Harry D Moore; Georges Leclercq; Anton Langerak; Tessa C C Kerre; Jean Plum; Bart Vandekerckhove
Generation of T cells from human embryonic stem cell-derived hematopoietic zones.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(11):6879-88.
2009: Tom Taghon; Inge Van de Walle; Greet De Smet; Magda De Smedt; Georges Leclercq; Bart Vandekerckhove; Jean Plum
Notch signaling is required for proliferation but not for differentiation at a well-defined beta-selection checkpoint during human T-cell development.
Blood 2009;113(14):3254-63.
2009: Inge Van de Walle; Greet De Smet; Magda De Smedt; Bart Vandekerckhove; Georges Leclercq; Jean Plum; Tom Taghon
An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells.
Blood 2009;113(13):2988-98.
2008: Tina Van Den Broeck; Frederik Stevenaert; Sylvie Taveirne; Veronique Debacker; Christel Vangestel; Bart Vandekerckhove; Tom Taghon; Patrick Matthys; Jean Plum; Werner Held; Mieke Dewerchin; Wayne M Yokoyama; Georges Leclercq
Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator.
Blood 2008;112(13):5046-51.
2008: Jean Plum; Magda De Smedt; Georges Leclercq; Tom Taghon; Tessa C C Kerre; Bart Vandekerckhove
Human intrathymic development: a selective approach.
Seminars in immunopathology 2008;30(4):411-23.
2007: Magda De Smedt; Tom Taghon; Inge Van de Walle; Greet De Smet; Georges Leclercq; Jean Plum
Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells.
Blood 2007;110(7):2696-703.
2007: Marlowe S Tessmer; Céline Fugere; Frederik Stevenaert; Olga V Naidenko; H Jonathan Chong; Georges Leclercq; Laurent Brossay
KLRG1 binds cadherins and preferentially associates with SHIP-1.
International immunology 2007;19(4):391-400.
2007: Inge Hoebeke; Magda De Smedt; Frank Stolz; Karin Pike-Overzet; Frank Staal; Jean Plum; Georges Leclercq
T-, B- and NK-lymphoid, but not myeloid cells arise from human CD34(+)CD38(-)CD7(+) common lymphoid progenitors expressing lymphoid-specific genes.
Leukemia 2007;21(2):311-9.
2006: Ann Sophie Franki; Katrien van Beneden; pieter dewint; Kirsten J L Hammond; Stijn Lambrecht; Georges Leclercq; Mitchell Kronenberg; Dieter Deforce; Dirk Elewaut
A unique lymphotoxin {alpha}beta-dependent pathway regulates thymic emigration of V{alpha}14 invariant natural killer T cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(24):9160-5.
2006: Inge Hoebeke; Magda De Smedt; Inge Van de Walle; Katia Reynvoet; Greet De Smet; Jean Plum; Georges Leclercq
Overexpression of HES-1 is not sufficient to impose T-cell differentiation on human hematopoietic stem cells.
Blood 2006;107(7):2879-81.
2005: Magda De Smedt; Inge Hoebeke; Katia Reynvoet; Georges Leclercq; Jean Plum
Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic-, or T-cell lineage in thymus microenvironment.
Blood 2005;106(10):3498-506.
2005: Frederik Stevenaert; Katrien van Beneden; Veerle De Colvenaer; Ann Sophie Franki; Veronique Debacker; Tom Boterberg; Dieter Deforce; Klaus Pfeffer; Jean Plum; Dirk Elewaut; Georges Leclercq
Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-beta receptor expression.
Blood 2005;106(3):956-62.
2005: Séverine Van Slambrouck; Virinder S Parmar; Sunil K Sharma; Bart De Bondt; Fleur Foré; Peter Coopman; Barbara W Vanhoecke; Tom Boterberg; Herman Depypere; Georges Leclercq; Marc Bracke
Tangeretin inhibits extracellular-signal-regulated kinase (ERK) phosphorylation.
FEBS letters 2005;579(7):1665-9.
2004: Ilse Claerhout; Philippe Kestelyn; Veronique Debacker; Hilde Beele; Georges Leclercq
Role of natural killer cells in the rejection process of corneal allografts in rats.
Transplantation 2004;77(5):676-82.
2003: Frederik Stevenaert; Katrien van Beneden; An De Creus; Veronique Debacker; Jean Plum; Georges Leclercq
Ly49E expression points toward overlapping, but distinct, natural killer (NK) cell differentiation kinetics and potential of fetal versus adult lymphoid progenitors.
Journal of leukocyte biology 2003;73(6):731-8.
2003: Tom Taghon; K Thys; Magda De Smedt; Floor Weerkamp; Frank Staal; Jean Plum; Georges Leclercq
Homeobox gene expression profile in human hematopoietic multipotent stem cells and T-cell progenitors: implications for human T-cell development.
Leukemia 2003;17(6):1157-63.
2002: Magda De Smedt; Katia Reynvoet; Tessa C C Kerre; Tom Taghon; Bruno Verhasselt; Bart Vandekerckhove; Georges Leclercq; Jean Plum
Active form of Notch imposes T cell fate in human progenitor cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):3021-9.
2002: An De Creus; Katrien van Beneden; Frederik Stevenaert; Veronique Debacker; Jean Plum; Georges Leclercq
Developmental and functional defects of thymic and epidermal V gamma 3 cells in IL-15-deficient and IFN regulatory factor-1-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6486-93.
2002: Katrien van Beneden; An De Creus; Frederik Stevenaert; Veronique Debacker; Jean Plum; Georges Leclercq
Expression of inhibitory receptors Ly49E and CD94/NKG2 on fetal thymic and adult epidermal TCR V gamma 3 lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3295-302.
2002: Karen P Fraser; Frances Gays; John Robinson; Katrien van Beneden; Georges Leclercq; Russell E Vance; David H Raulet; Colin G Brooks
NK cells developing in vitro from fetal mouse progenitors express at least one member of the Ly49 family that is acquired in a time-dependent and stochastic manner independently of CD94 and NKG2.
European journal of immunology 2002;32(3):868-78.
2002: Tom Taghon; Frank Stolz; Magda De Smedt; Maggy Cnockaert; Bruno Verhasselt; Jean Plum; Georges Leclercq
HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor.
Blood 2002;99(4):1197-204.
2002: Marc E Brack; Tom Boterberg; Herman Depypere; Christophe Stove; Georges Leclercq; Marc M Mareel
The citrus methoxyflavone tangeretin affects human cell-cell interactions.
Advances in experimental medicine and biology 2002;505():135-9.
2001: Tom Taghon; Magda De Smedt; Frank Stolz; M Cnockaert; Jean Plum; Georges Leclercq
Enforced expression of GATA-3 severely reduces human thymic cellularity.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4468-75.
2001: Katrien van Beneden; Frederik Stevenaert; An De Creus; Veronique Debacker; Jan A De Boever; Jean Plum; Georges Leclercq
Expression of Ly49E and CD94/NKG2 on fetal and adult NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4302-11.
2000: An De Creus; Katrien van Beneden; Tom Taghon; Frank Stolz; Veronique Debacker; Jean Plum; Georges Leclercq
Langerhans cells that have matured in vivo in the absence of T cells are fully capable of inducing a helper CD4 as well as a cytotoxic CD8 response.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):645-53.
2000: Magda De Smedt; Bruno Verhasselt; Tessa C C Kerre; D Vanhecke; Evelien Naessens; Georges Leclercq; J C Renauld; J Van Snick; Jean Plum
Signals from the IL-9 receptor are critical for the early stages of human intrathymic T cell development.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):1761-7.
2000: Jean Plum; Magda De Smedt; Bruno Verhasselt; Tessa C C Kerre; D Vanhecke; Bart Vandekerckhove; Georges Leclercq
Human T lymphopoiesis. In vitro and in vivo study models.
Annals of the New York Academy of Sciences 2000;917():724-31.
1999: Katrien van Beneden; An De Creus; Veronique Debacker; Jan A De Boever; Jean Plum; Georges Leclercq
Murine fetal natural killer cells are functionally and structurally distinct from adult natural killer cells.
Journal of leukocyte biology 1999;66(4):625-33.
1999: Jean Plum; Magda De Smedt; Bruno Verhasselt; Fritz Offner; Tessa C C Kerre; D Vanhecke; Georges Leclercq; Bart Vandekerckhove
In vitro intrathymic differentiation kinetics of human fetal liver CD34+CD38- progenitors reveals a phenotypically defined dendritic/T-NK precursor split.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):60-8.
1997: D Vanhecke; Bruno Verhasselt; Magda De Smedt; Georges Leclercq; Jean Plum; Bart Vandekerckhove
Human thymocytes become lineage committed at an early postselection CD69+ stage, before the onset of functional maturation.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):5973-83.
1997: Fritz Offner; Katrien van Beneden; Veronique Debacker; D Vanhecke; Bart Vandekerckhove; Jean Plum; Georges Leclercq
Phenotypic and functional maturation of TCR gammadelta cells in the human thymus.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4634-41.
1997: D Vanhecke; Bruno Verhasselt; Magda De Smedt; B De Paepe; Georges Leclercq; Jean Plum; Bart Vandekerckhove
MHC class II molecules are required for initiation of positive selection but not during terminal differentiation of human CD4 single positive thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):3730-7.
1996: Georges Leclercq; Jean Plum
Thymic development of V gamma 3 cells.
Seminars in immunology 1996;8(6):315-21.
1996: Jean Plum; Magda De Smedt; Georges Leclercq; Bruno Verhasselt; Bart Vandekerckhove
Interleukin-7 is a critical growth factor in early human T-cell development.
Blood 1996;88(11):4239-45.
1996: Georges Leclercq; Veronique Debacker; M de Smedt; Jean Plum
Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells.
The Journal of experimental medicine 1996;184(2):325-36.
1995: D Vanhecke; Bruno Verhasselt; Veronique Debacker; Georges Leclercq; Jean Plum; Bart Vandekerckhove
Differentiation to T helper cells in the thymus. Gradual acquisition of T helper cell function by CD3+CD4+ cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4711-8.
1995: D Vanhecke; Georges Leclercq; Jean Plum; Bart Vandekerckhove
Characterization of distinct stages during the differentiation of human CD69+CD3+ thymocytes and identification of thymic emigrants.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(4):1862-72.
1995: Jean Plum; Magda De Smedt; Georges Leclercq; Bart Vandekerckhove
Influence of TGF-beta on murine thymocyte development in fetal thymus organ culture.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(11):5789-98.
1995: Georges Leclercq; Jean Plum
Stimulation of TCR V gamma 3 cells by gram-negative bacteria.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(10):5313-9.
1995: Georges Leclercq; Magda De Smedt; Jean Plum
Cytokine dependence of V gamma 3 thymocytes: mature but not immature V gamma 3 cells require endogenous IL-2 and IL-7 to survive--evidence for cytokine redundancy.
International immunology 1995;7(5):843-51.
1994: Georges Leclercq; Jean Plum
Developmentally ordered appearance of a functional Fc gamma receptor on TCR V gamma 3 thymocytes. Evidence for stimulation-induced expression.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(6):2429-35.
1994: Jean Plum; Magda De Smedt; Marie-Paule Defresne; Georges Leclercq; Bart Vandekerckhove
Human CD34+ fetal liver stem cells differentiate to T cells in a mouse thymic microenvironment.
Blood 1994;84(5):1587-93.
1994: Magda De Smedt; Georges Leclercq; Bart Vandekerckhove; Jean Plum
Human fetal liver cells differentiate into thymocytes in chimeric mouse fetal thymus organ culture.
Advances in experimental medicine and biology 1994;355():27-31.