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Elizabeth Ledgerwood

Research Profile

Chemicals & Drugs

Anatomy

Phenomena

Oxidation-Reduction

Living Beings

Physiology

Disorders

Thrombocytopenia

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Publications

TOP 3
Tracy M Josephs; Kara L Bren; Gillian Hughes; Matthew D Liptak; Alexandra Lo; Rebecca M Smith; Sigurd M Wilbanks; Elizabeth C Ledgerwood
Conformational change and human cytochrome c function: mutation of residue 41 modulates caspase activation and destabilizes Met-80 coordination.
Reagan M Jarvis; Stephanie M Hughes; Elizabeth C Ledgerwood
Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells.
Elisabeth Cramer Bordé; Yasmine Ouzegdouh; Elizabeth C Ledgerwood; Ian M Morison
Congenital thrombocytopenia and cytochrome C mutation: a matter of birth and death.

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All Publications

2013: Tracy M Josephs; Kara L Bren; Gillian Hughes; Matthew D Liptak; Alexandra Lo; Rebecca M Smith; Sigurd M Wilbanks; Elizabeth C Ledgerwood
Conformational change and human cytochrome c function: mutation of residue 41 modulates caspase activation and destabilizes Met-80 coordination.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2013;18(3):289-97.
2012: Reagan M Jarvis; Stephanie M Hughes; Elizabeth C Ledgerwood
Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells.
Free radical biology & medicine 2012;53(7):1522-30.
2011: Elisabeth Cramer Bordé; Yasmine Ouzegdouh; Elizabeth C Ledgerwood; Ian M Morison
Congenital thrombocytopenia and cytochrome C mutation: a matter of birth and death.
Seminars in thrombosis and hemostasis 2011;37(6):664-72.
2011: Matthew D Liptak; Robert D Fagerlund; Elizabeth C Ledgerwood; Sigurd M Wilbanks; Kara L Bren
The proapoptotic G41S mutation to human cytochrome c alters the heme electronic structure and increases the electron self-exchange rate.
Journal of the American Chemical Society 2011;133(5):1153-5.
2010: Carolyn M Porteous; Angela Logan; Cameron Evans; Elizabeth C Ledgerwood; David K Menon; Franklin Aigbirhio; Robin A J Smith; Michael P Murphy
Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: implications for mitochondria-specific therapies and probes.
Biochimica et biophysica acta 2010;1800(9):1009-17.
2009: Dana Westphal; Elizabeth C Ledgerwood; Joel D A Tyndall; Merilyn Hibma; Norihito Ueda; Stephen B Fleming; Andrew A Mercer
The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax.
Apoptosis : an international journal on programmed cell death 2009;14(11):1317-30.
2009: Elizabeth C Ledgerwood; Ian M Morison
Targeting the apoptosome for cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(2):420-4.
2008: Ian M Morison; Elisabeth M Cramer Bordé; Emma J Cheesman; Pak Leng Cheong; Andrew J Holyoake; Serge Fichelson; Robert Weeks; Alexandra Lo; Stefan M K Davies; Sigurd M Wilbanks; Robert D Fagerlund; Mathew William Ludgate; Fernanda M da Silva Tatley; Melanie S A Coker; Nicholas A Bockett; Gillian Hughes; Diana A Pippig; Mark P Smith; Claude Capron; Elizabeth C Ledgerwood
A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia.
Nature genetics 2008;40(4):387-9.
2007: Reagan M Jarvis; Jana Göttert; Michael P Murphy; Elizabeth C Ledgerwood
Mitochondria-targeted antioxidants do not prevent tumour necrosis factor-induced necrosis of L929 cells.
Free radical research 2007;41(9):1041-6.
2007: Dana Westphal; Elizabeth C Ledgerwood; Merilyn Hibma; Stephen B Fleming; Ellena M Whelan; Andrew A Mercer
A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus ORF virus.
Journal of virology 2007;81(13):7178-88.
2005: Gillian Hughes; Michael P Murphy; Elizabeth C Ledgerwood
Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants.
The Biochemical journal 2005;389(Pt 1):83-9.
2003: R A J Smith; Geoffrey F Kelso; Frances H Blaikie; Carolyn M Porteous; Elizabeth C Ledgerwood; Gillian Hughes; Andrew M James; Meredith F Ross; Jordi Asin-Cayuela; Helena M Cochemé; Aleksandra Filipovska; Michael P Murphy
Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences.
Biochemical Society transactions 2003;31(Pt 6):1295-9.
2002: Geoffrey F Kelso; Carolyn M Porteous; Gillian Hughes; Elizabeth C Ledgerwood; Alison M Gane; Robin A J Smith; Michael P Murphy
Prevention of mitochondrial oxidative damage using targeted antioxidants.
Annals of the New York Academy of Sciences 2002;959():263-74.
2001: Geoffrey F Kelso; Carolyn M Porteous; CV Coulter; Gillian Hughes; WK Porteous; Elizabeth C Ledgerwood; Robin A J Smith; Michael P Murphy
Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties.
The Journal of biological chemistry 2001;276(7):4588-96.
2000: J L Scarlett; Philip W Sheard; Gillian Hughes; Elizabeth C Ledgerwood; H H Ku; Michael P Murphy
Changes in mitochondrial membrane potential during staurosporine-induced apoptosis in Jurkat cells.
FEBS letters 2000;475(3):267-72.