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Richard Leduc

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Anatomy

Genes & Molecular Sequences

Amino Acid Sequence

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Cercopithecus aethiops

Phenomena

Protein Binding

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Co-Publications
Name
41
Escher, Emanuel
39
Guillemette, Gaétan
19
Lavigne, Pierre
14
Denault, Jean-Bernard
12
Laporte, Stephane
9
Auger-Messier, Mannix
9
Boucard, Antony
9
Longpré, Jean-Michel
8
Leclerc, Patrice
8
Holleran, Brian
7
Clément, Martin
6
Beaulieu, Marie-Eve
6
Dufour, Erick
5
Proulx, Christophe
5
Martin, Stéphane

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Publications

TOP 3
Boulais Philip E; Dulude Dominic; Cabana Jérôme; Heveker Nikolaus; Escher Emanuel; Lavigne Pierre; Leduc Richard
Photolabeling identifies transmembrane domain 4 of CXCR4 as a T140 binding site.
Domazet Ivana; Martin Stéphane S; Holleran Brian J; Morin Marie-Eve; Lacasse Patrick; Lavigne Pierre; Escher Emanuel; Leduc Richard; Guillemette Gaétan
The fifth transmembrane domain of angiotensin II Type 1 receptor participates in the formation of the ligand-binding pocket and undergoes a counterclockwise rotation upon receptor activation.
Clément Martin; Cabana Jérôme; Holleran Brian J; Leduc Richard; Guillemette Gaétan; Lavigne Pierre; Escher Emanuel
Activation induces structural changes in the liganded angiotensin II type 1 receptor.

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All Publications

2009: Boulais Philip E; Dulude Dominic; Cabana Jérôme; Heveker Nikolaus; Escher Emanuel; Lavigne Pierre; Leduc Richard
Photolabeling identifies transmembrane domain 4 of CXCR4 as a T140 binding site.
Biochemical pharmacology 2009;78(11):1382-90.
2009: Domazet Ivana; Martin Stéphane S; Holleran Brian J; Morin Marie-Eve; Lacasse Patrick; Lavigne Pierre; Escher Emanuel; Leduc Richard; Guillemette Gaétan
The fifth transmembrane domain of angiotensin II Type 1 receptor participates in the formation of the ligand-binding pocket and undergoes a counterclockwise rotation upon receptor activation.
The Journal of biological chemistry 2009;284(46):31953-61.
2009: Clément Martin; Cabana Jérôme; Holleran Brian J; Leduc Richard; Guillemette Gaétan; Lavigne Pierre; Escher Emanuel
Activation induces structural changes in the liganded angiotensin II type 1 receptor.
The Journal of biological chemistry 2009;284(39):26603-12.
2009: Domazet Ivana; Holleran Brian J; Martin Stéphane S; Lavigne Pierre; Leduc Richard; Escher Emanuel; Guillemette Gaétan
The second transmembrane domain of the human type 1 angiotensin II receptor participates in the formation of the ligand binding pocket and undergoes integral pivoting movement during the process of receptor activation.
The Journal of biological chemistry 2009;284(18):11922-9.
2009: Longpré Jean-Michel; McCulloch Daniel R; Koo Bon-Hun; Alexander J Preston; Apte Suneel S; Leduc Richard
Characterization of proADAMTS5 processing by proprotein convertases.
The international journal of biochemistry & cell biology 2009;41(5):1116-26.
2009: Holleran Brian J; Domazet Ivana; Beaulieu Marie-Eve; Yan Li Ping; Guillemette Gaétan; Lavigne Pierre; Escher Emanuel; Leduc Richard
Identification of transmembrane domain 6 & 7 residues that contribute to the binding pocket of the urotensin II receptor.
Biochemical pharmacology 2009;77(8):1374-82.
2009: Béliveau François; Désilets Antoine; Leduc Richard
Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptides.
The FEBS journal 2009;276(8):2213-26.
2009: Clément Martin; Guillemette Gaétan; Leduc Richard; Escher Emanuel
Structural changes in the binding pocket of the liganded angiotensin II receptor AT1 during activation.
Advances in experimental medicine and biology 2009;611():341-2.
2009: Arsenault J; Renaud M P La-Haye; Clément M; Fillion D; Guillemette G; Leduc R; Lavigne P; Escher E
Temperature-induced ligand contact point variations of the hAT1 receptor and of the constitutively active mutant N111G-hAT1.
Advances in experimental medicine and biology 2009;611():339-40.
2009: Fillion D; Guillemette G; Leduc R; Escher E
Photoprobe peptides to map the interactions of angiotensin II with its receptor AT1.
Advances in experimental medicine and biology 2009;611():329-30.
2008: Proulx Christophe D; Holleran Brian J; Boucard Antony A; Escher Emanuel; Guillemette Gaétan; Leduc Richard
Mutational analysis of the conserved Asp2.50 and ERY motif reveals signaling bias of the urotensin II receptor.
Molecular pharmacology 2008;74(3):552-61.
2008: Proulx Christophe D; Holleran Brian J; Lavigne Pierre; Escher Emanuel; Guillemette Gaétan; Leduc Richard
Biological properties and functional determinants of the urotensin II receptor.
Peptides 2008;29(5):691-9.
2008: Désilets Antoine; Béliveau François; Vandal Guillaume; McDuff François-Olivier; Lavigne Pierre; Leduc Richard
Mutation G827R in matriptase causing autosomal recessive ichthyosis with hypotrichosis yields an inactive protease.
The Journal of biological chemistry 2008;283(16):10535-42.
2008: Leclerc Patrice C; Proulx Christophe D; Arguin Guillaume; Bélanger Simon; Gobeil Fernand; Escher Emanuel; Leduc Richard; Guillemette Gaétan
Ascorbic acid decreases the binding affinity of the AT1 receptor for angiotensin II.
American journal of hypertension 2008;21(1):67-71.
2007: Arsenault J; Renaud M P La Haye; Clément M; Fillion D; Guillemette G; Leduc R; Lavigne P; Escher E
Temperature-dependent variations of ligand-receptor contact points in hAT(1).
Journal of peptide science : an official publication of the European Peptide Society 2007;13(9):575-80.
2007: Martin Stéphane S; Holleran Brian J; Escher Emanuel; Guillemette Gaétan; Leduc Richard
Activation of the angiotensin II type 1 receptor leads to movement of the sixth transmembrane domain: analysis by the substituted cysteine accessibility method.
Molecular pharmacology 2007;72(1):182-90.
2007: Koo Bon-Hun; Longpré Jean-Michel; Somerville Robert P T; Alexander J Preston; Leduc Richard; Apte Suneel S
Regulation of ADAMTS9 secretion and enzymatic activity by its propeptide.
The Journal of biological chemistry 2007;282(22):16146-54.
2007: Holleran Brian J; Beaulieu Marie-Eve; Proulx Christophe D; Lavigne Pierre; Escher Emanuel; Leduc Richard
Photolabelling the urotensin II receptor reveals distinct agonist- and partial-agonist-binding sites.
The Biochemical journal 2007;402(1):51-61.
2006: Leclerc Patrice C; Lanctot Pascal M; Auger-Messier Mannix; Escher Emanuel; Leduc Richard; Guillemette Gaetan
S-nitrosylation of cysteine 289 of the AT1 receptor decreases its binding affinity for angiotensin II.
British journal of pharmacology 2006;148(3):306-13.
2006: Koo Bon-Hun; Longpré Jean-Michel; Somerville Robert P T; Alexander J Preston; Leduc Richard; Apte Suneel S
Cell-surface processing of pro-ADAMTS9 by furin.
The Journal of biological chemistry 2006;281(18):12485-94.
2006: Désilets Antoine; Longpré Jean-Michel; Beaulieu Marie-Eve; Leduc Richard
Inhibition of human matriptase by eglin c variants.
FEBS letters 2006;580(9):2227-32.
2006: Lanctôt Pascal M; Leclerc Patrice C; Escher Emanuel; Guillemette Gaétan; Leduc Richard
Role of N-glycan-dependent quality control in the cell-surface expression of the AT1 receptor.
Biochemical and biophysical research communications 2006;340(2):395-402.
2006: Clément Martin; Chamberland Caroline; Pérodin Jacqueline; Leduc Richard; Guillemette Gaétan; Escher Emanuel
The active and the inactive form of the hAT1 receptor have an identical ligand-binding environment: an MPA study on a constitutively active angiotensin II receptor mutant.
Journal of receptor and signal transduction research 2006;26(5-6):417-33.
2005: Methogo Ruth Menque; Dufresne-Martin Geneviève; Leclerc Patrice; Leduc Richard; Klarskov Klaus
Mass spectrometric peptide fingerprinting of proteins after Western blotting on polyvinylidene fluoride and enhanced chemiluminescence detection.
Journal of proteome research 2005;4(6):2216-24.
2005: Auger-Messier Mannix; Turgeon Eric S; Leduc Richard; Escher Emanuel; Guillemette Gaetan
The constitutively active N111G-AT1 receptor for angiotensin II modifies the morphology and cytoskeletal organization of HEK-293 cells.
Experimental cell research 2005;308(1):188-95.
2005: Lanctot Pascal M; Leclerc Patrice C; Clément Martin; Auger-Messier Mannix; Escher Emanuel; Leduc Richard; Guillemette Gaétan
Importance of N-glycosylation positioning for cell-surface expression, targeting, affinity and quality control of the human AT1 receptor.
The Biochemical journal 2005;390(Pt 1):367-76.
2005: Clément Martin; Martin Stéphane S; Beaulieu Marie-Eve; Chamberland Caroline; Lavigne Pierre; Leduc Richard; Guillemette Gaétan; Escher Emanuel
Determining the environment of the ligand binding pocket of the human angiotensin II type I (hAT1) receptor using the methionine proximity assay.
The Journal of biological chemistry 2005;280(29):27121-9.
2005: Dufour Erick K; Désilets Antoine; Longpré Jean-Michel; Leduc Richard
Stability of mutant serpin/furin complexes: dependence on pH and regulation at the deacylation step.
Protein science : a publication of the Protein Society 2005;14(2):303-15.
2005: Proulx Christophe D; Simaan May; Escher Emanuel; Laporte Stéphane A; Guillemette Gaétan; Leduc Richard
Involvement of a cytoplasmic-tail serine cluster in urotensin II receptor internalization.
The Biochemical journal 2005;385(Pt 1):115-23.
2004: Martin Stéphane S; Boucard Antony A; Clément Martin; Escher Emanuel; Leduc Richard; Guillemette Gaétan
Analysis of the third transmembrane domain of the human type 1 angiotensin II receptor by cysteine scanning mutagenesis.
The Journal of biological chemistry 2004;279(49):51415-23.
2004: Auger-Messier Mannix; Arguin Guillaume; Chaloux Benoit; Leduc Richard; Escher Emanuel; Guillemette Gaetan
Down-regulation of inositol 1,4,5-trisphosphate receptor in cells stably expressing the constitutively active angiotensin II N111G-AT(1) receptor.
Molecular endocrinology (Baltimore, Md.) 2004;18(12):2967-80.
2004: Somerville Robert P T; Longpré Jean-Michel; Apel Elizabeth D; Lewis Renate M; Wang Lauren W; Sanes Joshua R; Leduc Richard; Apte Suneel S
ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain.
The Journal of biological chemistry 2004;279(34):35159-75.
2004: Longpré Jean-Michel; Leduc Richard
Identification of prodomain determinants involved in ADAMTS-1 biosynthesis.
The Journal of biological chemistry 2004;279(32):33237-45.
2004: Bissonnette Lyne; Charest Gabriel; Longpré Jean-Michel; Lavigne Pierre; Leduc Richard
Identification of furin pro-region determinants involved in folding and activation.
The Biochemical journal 2004;379(Pt 3):757-63.
2003: Auger-Messier Mannix; Clement Martin; Lanctot Pascal M; Leclerc Patrice C; Leduc Richard; Escher Emanuel; Guillemette Gaetan
The constitutively active N111G-AT1 receptor for angiotensin II maintains a high affinity conformation despite being uncoupled from its cognate G protein Gq/11alpha.
Endocrinology 2003;144(12):5277-84.
2003: Boucard Antony A; Roy Marise; Beaulieu Marie-Eve; Lavigne Pierre; Escher Emanuel; Guillemette Gaetan; Leduc Richard
Constitutive activation of the angiotensin II type 1 receptor alters the spatial proximity of transmembrane 7 to the ligand-binding pocket.
The Journal of biological chemistry 2003;278(38):36628-36.
2003: Somerville Robert P T; Longpre Jean-Michel; Jungers Katherine A; Engle J Michael; Ross Monique; Evanko Stephen; Wight Thomas N; Leduc Richard; Apte Suneel S
Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1.
The Journal of biological chemistry 2003;278(11):9503-13.
2003: Boucard Antony A; Sauvé Simon S; Guillemette Gaétan; Escher Emanuel; Leduc Richard
Photolabelling the rat urotensin II/GPR14 receptor identifies a ligand-binding site in the fourth transmembrane domain.
The Biochemical journal 2003;370(Pt 3):829-38.
2002: Pérodin Jacqueline; Deraët Maud; Auger-Messier Mannix; Boucard Antony A; Rihakova Lenka; Beaulieu Marie-Eve; Lavigne Pierre; Parent Jean-Luc; Guillemette Gaétan; Leduc Richard; Escher Emanuel
Residues 293 and 294 are ligand contact points of the human angiotensin type 1 receptor.
Biochemistry 2002;41(48):14348-56.
2002: Leclerc Patrice C; Auger-Messier Mannix; Lanctot Pascal M; Escher Emanuel; Leduc Richard; Guillemette Gaétan
A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling.
Endocrinology 2002;143(12):4702-10.
2002: Cantin André M; Woods Donald E; Cloutier Diane; Dufour Erick K; Leduc Richard
Polyethylene glycol conjugation at Cys232 prolongs the half-life of alpha1 proteinase inhibitor.
American journal of respiratory cell and molecular biology 2002;27(6):659-65.
2002: Denault Jean; Bissonnette Lyne; Longpré Jean; Charest Gabriel; Lavigne Pierre; Leduc Richard
Ectodomain shedding of furin: kinetics and role of the cysteine-rich region.
FEBS letters 2002;527(1-3):309-14.
2002: Blais Véronique; Fugère Martin; Denault Jean-Bernard; Klarskov Klaus; Day Robert; Leduc Richard
Processing of proendothelin-1 by members of the subtilisin-like pro-protein convertase family.
FEBS letters 2002;524(1-3):43-8.
2002: Deraët M; Rihakova L; Boucard A; Pèrodin J; Sauvé S; Mathieu A P; Guillemette G; Leduc R; Lavigne P; Escher E
Angiotensin II is bound to both receptors AT1 and AT2, parallel to the transmembrane domains and in an extended form.
Canadian journal of physiology and pharmacology 2002;80(5):418-25.
2002: Fugère Martin; Limperis Polizois C; Beaulieu-Audy Véronique; Gagnon Frédéric; Lavigne Pierre; Klarskov Klaus; Leduc Richard; Day Robert
Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains.
The Journal of biological chemistry 2002;277(10):7648-56.
2002: Rihakova Lenka; Deraët Maud; Auger-Messier Mannix; Pérodin Jacqueline; Boucard Antony A; Guillemette Gaétan; Leduc Richard; Lavigne Pierre; Escher Emanuel
Methionine proximity assay, a novel method for exploring peptide ligand-receptor interaction.
Journal of receptor and signal transduction research 2002;22(1-4):297-313.
2002: Cantin André M; Woods Donald E; Cloutier Diane; Héroux Julie; Dufour Erick K; Leduc Richard
Leukocyte elastase inhibition therapy in cystic fibrosis: role of glycosylation on the distribution of alpha-1-proteinase inhibitor in blood versus lung.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2002;15(2):141-8.
2001: Dufour E K; Denault J B; Bissonnette L; Hopkins P C; Lavigne P; Leduc R
The contribution of arginine residues within the P6-P1 region of alpha 1-antitrypsin to its reaction with furin.
The Journal of biological chemistry 2001;276(42):38971-9.
2001: Bush G; diSibio G; Miyamoto A; Denault J B; Leduc R; Weinmaster G
Ligand-induced signaling in the absence of furin processing of Notch1.
Developmental biology 2001;229(2):494-502.
2001: Dubois C M; Blanchette F; Laprise M H; Leduc R; Grondin F; Seidah N G
Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme.
The American journal of pathology 2001;158(1):305-16.
2000: Rodriguez-Manzaneque J C; Milchanowski A B; Dufour E K; Leduc R; Iruela-Arispe M L
Characterization of METH-1/ADAMTS1 processing reveals two distinct active forms.
The Journal of biological chemistry 2000;275(43):33471-9.
2000: Boucard A A; Wilkes B C; Laporte S A; Escher E; Guillemette G; Leduc R
Photolabeling identifies position 172 of the human AT(1) receptor as a ligand contact point: receptor-bound angiotensin II adopts an extended structure.
Biochemistry 2000;39(32):9662-70.
2000: Gosselin M J; Leclerc P C; Auger-Messier M; Guillemette G; Escher E; Leduc R
Molecular cloning of a ferret angiotensin II AT(1) receptor reveals the importance of position 163 for Losartan binding.
Biochimica et biophysica acta 2000;1497(1):94-102.
2000: Denault J B; Lazure C; Day R; Leduc R
Comparative characterization of two forms of recombinant human SPC1 secreted from Schneider 2 cells.
Protein expression and purification 2000;19(1):113-24.
2000: Bergeron F; Leduc R; Day R
Subtilase-like pro-protein convertases: from molecular specificity to therapeutic applications.
Journal of molecular endocrinology 2000;24(1):1-22.
1999: Lanctôt P M; Leclerc P C; Escher E; Leduc R; Guillemette G
Role of N-glycosylation in the expression and functional properties of human AT1 receptor.
Biochemistry 1999;38(27):8621-7.
1999: Laporte S A; Boucard A A; Servant G; Guillemette G; Leduc R; Escher E
Determination of peptide contact points in the human angiotensin II type I receptor (AT1) with photosensitive analogs of angiotensin II.
Molecular endocrinology (Baltimore, Md.) 1999;13(4):578-86.
1999: Chrétien L; Laporte S A; Escher E; Leduc R; Guillemette G
The bradykinin B2 receptor couples less efficiently than the angiotensin AT1 receptor to the G protein Gq in transiently transfected COS-7 cells.
Receptors & channels 1999;6(6):425-33.
1998: Lora M; Denault J B; Leduc R; de Brum-Fernandes A J
Systematic pharmacological approach to the characterization of NSAIDs.
Prostaglandins, leukotrienes, and essential fatty acids 1998;59(1):55-62.
1998: Dufour E K; Denault J B; Hopkins P C; Leduc R
Serpin-like properties of alpha1-antitrypsin Portland towards furin convertase.
FEBS letters 1998;426(1):41-6.
1998: Laporte S A; Roy S F; Escher E; Guillemette G; Leduc R
Essential role of leucine222 in mediating signal transduction of the human angiotensin II type 1 receptor.
Receptors & channels 1998;5(2):103-12.
1997: Richard D E; Laporte S A; Bernier S G; Leduc R; Guillemette G
Desensitization of AT1 receptor-mediated cellular responses requires long term receptor down-regulation in bovine adrenal glomerulosa cells.
Endocrinology 1997;138(9):3828-35.
1997: Chrétien L; Laporte S A; Escher E; Leduc R; Guillemette G
Use of LiCl in phospholipase C assays masks the impaired functionality of a mutant angiotensin II receptor.
Cellular signalling 1997;9(5):379-82.
1997: Roy S F; Laporte S A; Escher E; Leduc R; Guillemette G
Epitope tagging and immunoreactivity of the human angiotensin II type 1 receptor.
Canadian journal of physiology and pharmacology 1997;75(6):690-5.
1997: Lora M; Morisset S; Ménard H A; Leduc R; de Brum-Fernandes A J
Expression of recombinant human cyclooxygenase isoenzymes in transfected COS-7 cells in vitro and inhibition by tenoxicam, indomethacin and aspirin.
Prostaglandins, leukotrienes, and essential fatty acids 1997;56(5):361-7.
1997: Kido T; Sawamura T; Hoshikawa H; D'Orléans-Juste P; Denault J B; Leduc R; Kimura J; Masaki T
Processing of proendothelin-1 at the C-terminus of big endothelin-1 is essential for proteolysis by endothelin-converting enzyme-1 in vivo.
European journal of biochemistry / FEBS 1997;244(2):520-6.
1997: Servant G; Laporte S A; Leduc R; Escher E; Guillemette G
Identification of angiotensin II-binding domains in the rat AT2 receptor with photolabile angiotensin analogs.
The Journal of biological chemistry 1997;272(13):8653-9.
1997: Mains R E; Berard C A; Denault J B; Zhou A; Johnson R C; Leduc R
PACE4: a subtilisin-like endoprotease with unique properties.
The Biochemical journal 1997;321 ( Pt 3)():587-93.
1996: Denault J B; Leduc R
Furin/PACE/SPC1: a convertase involved in exocytic and endocytic processing of precursor proteins.
FEBS letters 1996;379(2):113-6.
1996: Laporte S A; Servant G; Richard D E; Escher E; Guillemette G; Leduc R
The tyrosine within the NPXnY motif of the human angiotensin II type 1 receptor is involved in mediating signal transduction but is not essential for internalization.
Molecular pharmacology 1996;49(1):89-95.
1996: Boulenger J P; Jerabek I; Jolicoeur F B; Lavallée Y J; Leduc R; Cadieux A
Elevated plasma levels of neuropeptide Y in patients with panic disorder.
The American journal of psychiatry 1996;153(1):114-6.
1996: Pérodin J; Bossé R; Gagnon S; Zhou L M; Bouley R; Leduc R; Escher E
Structure-activity relationship of the agonist-antagonist transition on the type 1 angiotensin II receptor; the search for inverse agonists.
Advances in experimental medicine and biology 1996;396():131-43.
1995: Dubois C M; Laprise M H; Blanchette F; Gentry L E; Leduc R
Processing of transforming growth factor beta 1 precursor by human furin convertase.
The Journal of biological chemistry 1995;270(18):10618-24.
1995: Denault J B; Claing A; D'Orléans-Juste P; Sawamura T; Kido T; Masaki T; Leduc R
Processing of proendothelin-1 by human furin convertase.
FEBS letters 1995;362(3):276-80.
1995: Denault J B; D'Orléans-Juste P; Masaki T; Leduc R
Inhibition of convertase-related processing of proendothelin-1.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S47-50.
1994: de Brum-Fernandes A J; Laporte S; Heroux M; Lora M; Patry C; Ménard H A; Dumais R; Leduc R
Expression of prostaglandin endoperoxide synthase-1 and prostaglandin endoperoxide synthase-2 in human osteoblasts.
Biochemical and biophysical research communications 1994;198(3):955-60.
1993: Vidricaire G; Denault J B; Leduc R
Characterization of a secreted form of human furin endoprotease.
Biochemical and biophysical research communications 1993;195(2):1011-8.
1993: Laporte S; Denault J B; D'Orléans-Juste P; Leduc R
Presence of furin mRNA in cultured bovine endothelial cells and possible involvement of furin in the processing of the endothelin precursor.
Journal of cardiovascular pharmacology 1993;22 Suppl 8():S7-10.

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