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Benjamin Lee

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Winnie F Tam; Gerlinde Wernig; Nan Zhu; Ernesto Bockamp; D Gary Gilliland; Patricia S Hähnel; Lothar Hennighausen; Andreas Kreft; Benjamin H Lee; Thomas Mercher; Rachel Okabe; Saskia V Pante; Glen Raffel; Gertraud W Robinson; Daniel Sasca; Andrea Schüler; Thomas Kindler
STAT5 is crucial to maintain leukemic stem cells in acute myelogenous leukemias induced by MOZ-TIF2.
Brynn T Kvinlaug; Stanley E Lazic; Benjamin H Lee; Rachel Okabe; Mukundhan Ramaswami; Christopher Sears; Peter J M Valk; Scott A Armstrong; Axel Benner; Lars Bullinger; Wai-In Chan; Inusha De Silva; Ruud Delwel; Hartmut Döhner; Donna Foster; D Gary Gilliland; Brian J P Huntly
Common and overlapping oncogenic pathways contribute to the evolution of acute myeloid leukemias.
S Wojiski; F C Guibal; T Kindler; Benjamin H Lee; Jonathan L Jesneck; A Fabian; D G Tenen; D Gary Gilliland
PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors.

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All Publications

2013: Winnie F Tam; Gerlinde Wernig; Nan Zhu; Ernesto Bockamp; D Gary Gilliland; Patricia S Hähnel; Lothar Hennighausen; Andreas Kreft; Benjamin H Lee; Thomas Mercher; Rachel Okabe; Saskia V Pante; Glen Raffel; Gertraud W Robinson; Daniel Sasca; Andrea Schüler; Thomas Kindler
STAT5 is crucial to maintain leukemic stem cells in acute myelogenous leukemias induced by MOZ-TIF2.
Cancer research 2013;73(1):373-84.
2011: Brynn T Kvinlaug; Stanley E Lazic; Benjamin H Lee; Rachel Okabe; Mukundhan Ramaswami; Christopher Sears; Peter J M Valk; Scott A Armstrong; Axel Benner; Lars Bullinger; Wai-In Chan; Inusha De Silva; Ruud Delwel; Hartmut Döhner; Donna Foster; D Gary Gilliland; Brian J P Huntly
Common and overlapping oncogenic pathways contribute to the evolution of acute myeloid leukemias.
Cancer research 2011;71(12):4117-29.
2009: S Wojiski; F C Guibal; T Kindler; Benjamin H Lee; Jonathan L Jesneck; A Fabian; D G Tenen; D Gary Gilliland
PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors.
Leukemia 2009;23(8):1462-71.
2009: Inga Hofmann; Elizabeth H Stover; Dana E Cullen; Junhao Mao; Kelly J Morgan; Benjamin H Lee; Michael G Kharas; Peter G Miller; Melanie G Cornejo; Rachel Okabe; Scott A Armstrong; Nico Ghilardi; Stephen Gould; Frederic J de Sauvage; Andrew P McMahon; D Gary Gilliland
Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis.
Cell stem cell 2009;4(6):559-67.
2009: Thomas Mercher; Glen D Raffel; Sandra A Moore; Melanie G Cornejo; Dominique Baudry-Bluteau; Nicolas Cagnard; Jonathan L Jesneck; Yana Pikman; Dana Cullen; Ifor Williams; Koichi Akashi; Hirokazu Shigematsu; Jean-Pierre Bourquin; Marco Giovannini; William Vainchenker; Ross Levine; Benjamin H Lee; Olivier A Bernard; D Gary Gilliland
The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.
The Journal of clinical investigation 2009;119(4):852-64.
2009: Melanie G Cornejo; Michael G Kharas; Miriam B Werneck; Séverine Le Bras; Sandra A Moore; Brian Ball; Marie Beylot-Barry; Scott J Rodig; Jon C Aster; Benjamin H Lee; Harvey Cantor; Jean-Philippe Merlio; D Gary Gilliland; Thomas Mercher
Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models.
Blood 2009;113(12):2746-54.
2008: Thomas Kindler; Melanie G Cornejo; Claudia Scholl; Jianing Liu; Dena S Leeman; J Erika Haydu; Stefan Fröhling; Benjamin H Lee; D Gary Gilliland
K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors.
Blood 2008;112(8):3373-82.
2008: Winnie F Tam; Ting-Lei Gu; Jing Chen; Benjamin H Lee; Lars Bullinger; Stefan Fröhling; Zhuang Wang; Stefano Monti; Todd R Golub; D Gary Gilliland
Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells.
Blood 2008;112(5):1981-92.
2008: Kim De Keersmaecker; Jennifer L Rocnik; Rafael Bernad; Benjamin H Lee; Dena Leeman; Olga Gielen; Hanne Verachtert; Cedric Folens; Sebastian Munck; Peter Marynen; Maarten Fornerod; D Gary Gilliland; Jan Cools
Kinase activation and transformation by NUP214-ABL1 is dependent on the context of the nuclear pore.
Molecular cell 2008;31(1):134-42.
2008: Gerlinde Wernig; Michael G Kharas; Rachel Okabe; Sandra A Moore; Dena S Leeman; Dana E Cullen; Maricel Gozo; Elizabeth P McDowell; Ross Levine; John Doukas; Chi Ching Mak; Glenn Noronha; Michael Martin; Yon D Ko; Benjamin H Lee; Richard M Soll; Ayalew Tefferi; John Hood; D Gary Gilliland
Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera.
Cancer cell 2008;13(4):311-20.
2007: Stefan Fröhling; Claudia Scholl; Ross Levine; Marc Loriaux; Titus Boggon; Olivier A Bernard; Roland Berger; Hartmut Döhner; Konstanze Döhner; Benjamin L Ebert; Sewit Teckie; Todd R Golub; Jingrui Jiang; Marcus Schittenhelm; Benjamin H Lee; James D Griffin; Richard M Stone; Michael C Heinrich; Michael W N Deininger; Brian J Druker; D Gary Gilliland
Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles.
Cancer cell 2007;12(6):501-13.
2007: Benjamin H Lee; Zuzana Tothova; Ross Levine; Kristina Anderson; Natalija Buza-Vidas; Dana E Cullen; Elizabeth P McDowell; Jennifer Adelsperger; Stefan Fröhling; Brian J P Huntly; Miloslav Beran; Sten Eirik W Jacobsen; D Gary Gilliland
FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia.
Cancer cell 2007;12(4):367-80.
2007: Claudia Scholl; Dimple Bansal; Konstanze Döhner; Karina Eiwen; Brian J P Huntly; Benjamin H Lee; Frank G Rücker; Richard F Schlenk; Lars Bullinger; Hartmut Döhner; D Gary Gilliland; Stefan Fröhling
The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis.
The Journal of clinical investigation 2007;117(4):1037-48.
2007: Zuzana Tothova; Ramya Kollipara; Brian J P Huntly; Benjamin H Lee; Diego H Castrillon; Dana E Cullen; Elizabeth P McDowell; Suzan Lazo-Kallanian; Ifor Williams; Christopher Sears; Scott A Armstrong; Emmanuelle Passegué; Ronald A DePinho; D Gary Gilliland
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.
Cell 2007;128(2):325-39.
2006: Dimple Bansal; Claudia Scholl; Stefan Fröhling; Elizabeth P McDowell; Benjamin H Lee; Konstanze Döhner; Patricia Ernst; Alan J Davidson; George Q Daley; Leonard I Zon; D Gary Gilliland; Brian J P Huntly
Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16924-9.
2006: Thomas Mercher; Gerlinde Wernig; Sandra A Moore; Ross Levine; Ting-Lei Gu; Stefan Fröhling; Dana Cullen; Roberto D Polakiewicz; Olivier A Bernard; Titus Boggon; Benjamin H Lee; D Gary Gilliland
JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model.
Blood 2006;108(8):2770-9.
2006: Jennifer L Rocnik; Rachel Okabe; Jin-Chen Yu; Benjamin H Lee; Neill Giese; David P Schenkein; D Gary Gilliland
Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.
Blood 2006;108(4):1339-45.
2006: Yana Pikman; Benjamin H Lee; Thomas Mercher; Elizabeth McDowell; Benjamin L Ebert; Maricel Gozo; Adam Cuker; Gerlinde Wernig; Sandra Moore; Ilene Galinsky; Daniel J DeAngelo; Jennifer J Clark; Stephanie J Lee; Todd R Golub; Martha Wadleigh; D Gary Gilliland; Ross Levine
MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.
PLoS medicine 2006;3(7):e270.
2006: Gerlinde Wernig; Thomas Mercher; Rachel Okabe; Ross Levine; Benjamin H Lee; D Gary Gilliland
Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model.
Blood 2006;107(11):4274-81.
2006: Elizabeth H Stover; Jing Chen; Cedric Folens; Benjamin H Lee; Nicole Mentens; Peter Marynen; Ifor Williams; D Gary Gilliland; Jan Cools
Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(21):8078-83.
2005: Jing Chen; Benjamin H Lee; Ifor Williams; Jeffery L Kutok; Constantine S Mitsiades; Nicole Duclos; Sarah Cohen; Jennifer Adelsperger; Rachel Okabe; Allison Coburn; Sandra Moore; Brian J P Huntly; Doriano Fabbro; Kenneth C Anderson; James D Griffin; D Gary Gilliland
FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies.
Oncogene 2005;24(56):8259-67.
2005: Benjamin H Lee; Ifor Williams; Ema Anastasiadou; Christina L Boulton; Sarah W Joseph; Sonia M Amaral; David P Curley; Nicole Duclos; Brian J P Huntly; Doriano Fabbro; James D Griffin; D Gary Gilliland
FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model.
Oncogene 2005;24(53):7882-92.
2005: Elizabeth H Stover; Jing Chen; Benjamin H Lee; Jan Cools; Elizabeth P McDowell; Jennifer Adelsperger; Dana Cullen; Allison Coburn; Sandra A Moore; Rachel Okabe; Doriano Fabbro; Paul W Manley; James D Griffin; D Gary Gilliland
The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo.
Blood 2005;106(9):3206-13.
2005: Joseph D Growney; Hirokazu Shigematsu; Zhe Li; Benjamin H Lee; Jennifer Adelsperger; Rebecca Rowan; David P Curley; Jeffery L Kutok; Koichi Akashi; Ifor Williams; Nancy A Speck; D Gary Gilliland
Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.
Blood 2005;106(2):494-504.
2005: Jing Chen; Ifor Williams; Benjamin H Lee; Nicole Duclos; Brian J P Huntly; Daniel J Donoghue; D Gary Gilliland
Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation.
Blood 2005;106(1):328-37.
2004: Brian J P Huntly; Hirokazu Shigematsu; Kenji Deguchi; Benjamin H Lee; Shinichi Mizuno; Nicole Duclos; Rebecca Rowan; Sonia M Amaral; David P Curley; Ifor Williams; Koichi Akashi; D Gary Gilliland
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.
Cancer cell 2004;6(6):587-96.
2004: Jing Chen; Daniel J DeAngelo; Jeffery L Kutok; Ifor Williams; Benjamin H Lee; Martha Wadleigh; Nicole Duclos; Sarah Cohen; Jennifer Adelsperger; Rachel Okabe; Allison Coburn; Ilene Galinsky; Brian J P Huntly; Pamela S Cohen; Thomas Meyer; Doriano Fabbro; Johannes Roesel; Lolita Banerji; James D Griffin; Sheng Xiao; Jonathan A Fletcher; Richard M Stone; D Gary Gilliland
PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(40):14479-84.
2003: Stefan Duensing; Benjamin H Lee; Paola Dal Cin; Karl Münger
Excessive centrosome abnormalities without ongoing numerical chromosome instability in a Burkitt's lymphoma.
Molecular cancer 2003;2():30.
2003: Benjamin H Lee; Suzanne George; Jeffery L Kutok
Langerhans cell histiocytosis involving the thymus. A case report and review of the literature.
Archives of pathology & laboratory medicine 2003;127(7):e294-7.
2003: Jan Cools; Elizabeth H Stover; Christina L Boulton; Jason Gotlib; Robert D Legare; Sonia M Amaral; David P Curley; Nicole Duclos; Rebecca Rowan; Jeffery L Kutok; Benjamin H Lee; Ifor Williams; Steven E Coutre; Richard M Stone; Daniel J DeAngelo; Peter Marynen; Paul W Manley; Thomas Meyer; Doriano Fabbro; Donna Neuberg; Ellen Weisberg; James D Griffin; D Gary Gilliland
PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRα-induced myeloproliferative disease.
Cancer cell 2003;3(5):459-69.
2002: Benjamin H Lee; Jonathan L Hecht; Jack L Pinkus; Geraldine S Pinkus
WT1, estrogen receptor, and progesterone receptor as markers for breast or ovarian primary sites in metastatic adenocarcinoma to body fluids.
American journal of clinical pathology 2002;117(5):745-50.
2002: Jonathan L Hecht; Benjamin H Lee; Jack L Pinkus; Geraldine S Pinkus
The value of Wilms tumor susceptibility gene 1 in cytologic preparations as a marker for malignant mesothelioma.
Cancer 2002;96(2):105-9.