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David Lee

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Anatomy

Phenomena

Living Beings

Cattle

Chemicals & Drugs

Physiology

Procedures

Concepts & Ideas

Compressive Strength

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Network (preview)

Co-Publications
Name
45
Bader, Dan
16
Knight, Martin
11
Shelton, Julia
10
Chowdhury, Tina
6
Heywood, Hannah
5
Screen, Hazel
3
Idowu, BD
2
Bouten, Carlijn
2
Frean, SP
1
Fefeu, Sandrine
1
Oomens, C W J
1
Poole, Anthony
1
Ross, Jacqueline
1
Kimmel, Eitan
1
Sengers, Bram

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Publications

TOP 3
Heywood Hannah K; Lee David A
Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes.
Heywood H K; Lee D A
Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes.
Chowdhury T T; Salter D M; Bader D L; Lee D A
Signal transduction pathways involving p38 MAPK, JNK, NFkappaB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1beta and dynamic compression.

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All Publications

2010: Heywood Hannah K; Lee David A
Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes.
Journal of cellular physiology 2010;222(1):248-53.
2008: Heywood H K; Lee D A
Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes.
Biochemical and biophysical research communications 2008;373(2):224-9.
2008: Chowdhury T T; Salter D M; Bader D L; Lee D A
Signal transduction pathways involving p38 MAPK, JNK, NFkappaB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1beta and dynamic compression.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2008;57(7):306-13.
2008: Chowdhury T T; Akanji O O; Salter D M; Bader D L; Lee D A
Dynamic compression influences interleukin-1beta-induced nitric oxide and prostaglandin E2 release by articular chondrocytes via alterations in iNOS and COX-2 expression.
Biorheology 2008;45(3-4):257-74.
2008: Chowdhury T T; Arghandawi S; Brand J; Akanji O O; Bader D L; Salter D M; Lee D A
Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs.
Arthritis research & therapy 2008;10(2):R35.
2007: Maeda Eijiro; Shelton Julia C; Bader Dan L; Lee David A
Time dependence of cyclic tensile strain on collagen production in tendon fascicles.
Biochemical and biophysical research communications 2007;362(2):399-404.
2006: Heywood Hannah K; Bader Dan L; Lee David A
Glucose concentration and medium volume influence cell viability and glycosaminoglycan synthesis in chondrocyte-seeded alginate constructs.
Tissue engineering 2006;12(12):3487-96.
2006: Screen Hazel R C; Chhaya Vivek H; Greenwald Steve E; Bader Dan L; Lee David A; Shelton Julia C
The influence of swelling and matrix degradation on the microstructural integrity of tendon.
Acta biomaterialia 2006;2(5):505-13.
2006: Chowdhury T T; Appleby R N; Salter D M; Bader D A; Lee D A
Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes.
Biomechanics and modeling in mechanobiology 2006;5(2-3):192-201.
2006: Knight M M; Bomzon Z; Kimmel E; Sharma A M; Lee D A; Bader D L
Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields.
Biomechanics and modeling in mechanobiology 2006;5(2-3):180-91.
2006: Heywood Hannah K; Bader Dan L; Lee David A
Rate of oxygen consumption by isolated articular chondrocytes is sensitive to medium glucose concentration.
Journal of cellular physiology 2006;206(2):402-10.
2006: Chowdhury T T; Bader D L; Lee D A
Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes.
Biochemical and biophysical research communications 2006;339(1):241-7.
2006: Campbell Jonathan J; Lee David A; Bader Dan L
Dynamic compressive strain influences chondrogenic gene expression in human mesenchymal stem cells.
Biorheology 2006;43(3-4):455-70.
2006: Chowdhury Tina T; Bader Dan L; Lee David A
Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs.
Biorheology 2006;43(3-4):413-29.
2006: Knight M M; Toyoda T; Lee D A; Bader D L
Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose.
Journal of biomechanics 2006;39(8):1547-51.
2005: Pingguan-Murphy B; Lee D A; Bader D L; Knight M M
Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles.
Archives of biochemistry and biophysics 2005;444(1):45-51.
2005: Sengers Bram G; Heywood Hannah K; Lee David A; Oomens Cees W J; Bader Dan L
Nutrient utilization by bovine articular chondrocytes: a combined experimental and theoretical approach.
Journal of biomechanical engineering 2005;127(5):758-66.
2005: Screen Hazel R C; Shelton Julia C; Bader Dan L; Lee David A
Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles.
Biochemical and biophysical research communications 2005;336(2):424-9.
2005: Screen Hazel R C; Shelton Julia C; Chhaya Vivek H; Kayser Michael V; Bader Dan L; Lee David A
The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles.
Annals of biomedical engineering 2005;33(8):1090-9.
2005: Wang Yak-Nam; Bouten C V C; Lee D A; Bader D L
Compression-induced damage in a muscle cell model in vitro.
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine 2005;219(1):1-12.
2004: Heywood Hannah K; Sembi Preetkamal K; Lee David A; Bader Dan L
Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs.
Tissue engineering 2004;10(9-10):1467-79.
2004: Chowdhury T T; Salter D M; Bader D L; Lee D A
Integrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes.
Biochemical and biophysical research communications 2004;318(4):873-81.
2004: Holloway I; Kayser M; Lee D A; Bader D L; Bentley G; Knight M M
Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12(1):17-24.
2004: Lee David A; Fefeu Sandrine; Edo-Ukeh Adrian A; Orengo Christine A; Slingsby Christine
EyeSite: a semi-automated database of protein families in the eye.
Nucleic acids research 2004;32(Database issue):D148-52.
2004: Wiseman Mike; Bader Dan L; Reisler Tom; Lee David A
Passage in monolayer influences the response of chondrocytes to dynamic compression.
Biorheology 2004;41(3-4):283-98.
2004: Lee David A; Knight Martin M
Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain.
Methods in molecular medicine 2004;100():307-24.
2004: Screen H R C; Lee D A; Bader D L; Shelton J C
An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties.
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine 2004;218(2):109-19.
2004: Lee David A; Martin Ivan
Bioreactor culture techniques for cartilage-tissue engineering.
Methods in molecular biology (Clifton, N.J.) 2004;238():159-70.
2003: Chowdhury T T; Bader D L; Lee D A
Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2003;11(9):688-96.
2003: Chowdhury Tina T; Bader Dan L; Shelton Julia C; Lee David A
Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression.
Archives of biochemistry and biophysics 2003;417(1):105-11.
2003: Berry Catherine C; Shelton Julia C; Bader Dan L; Lee David A
Influence of external uniaxial cyclic strain on oriented fibroblast-seeded collagen gels.
Tissue engineering 2003;9(4):613-24.
2003: Knight Martin M; Roberts Susan R; Lee David A; Bader Dan L
Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death.
American journal of physiology. Cell physiology 2003;284(4):C1083-9.
2003: Lee David A; Reisler Tom; Bader Dan L
Expansion of chondrocytes for tissue engineering in alginate beads enhances chondrocytic phenotype compared to conventional monolayer techniques.
Acta orthopaedica Scandinavica 2003;74(1):6-15.
2003: Shelton Julia C; Bader Dan L; Lee David A
Mechanical conditioning influences the metabolic response of cell-seeded constructs.
Cells, tissues, organs 2003;175(3):140-50.
2003: Screen H R C; Lee D A; Bader D L; Shelton J C
Development of a technique to determine strains in tendons using the cell nuclei.
Biorheology 2003;40(1-3):361-8.
2003: Berry C C; Cacou C; Lee D A; Bader D L; Shelton J C
Dermal fibroblasts respond to mechanical conditioning in a strain profile dependent manner.
Biorheology 2003;40(1-3):337-45.
2002: Knight M M; van de Breevaart Bravenboer J; Lee D A; van Osch G J V M; Weinans H; Bader D L
Cell and nucleus deformation in compressed chondrocyte-alginate constructs: temporal changes and calculation of cell modulus.
Biochimica et biophysica acta 2002;1570(1):1-8.
2002: Bader D L; Ohashi T; Knight M M; Lee D A; Sato M
Deformation properties of articular chondrocytes: a critique of three separate techniques.
Biorheology 2002;39(1-2):69-78.
2001: Chowdhury T T; Bader D L; Lee D A
Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs.
Biochemical and biophysical research communications 2001;285(5):1168-74.
2001: Knight M M; Idowu B D; Lee D A; Bader D L
Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique.
Medical & biological engineering & computing 2001;39(3):397-404.
2001: Knight M M; Ross J M; Sherwin A F; Lee D A; Bader D L; Poole C A
Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose.
Biochimica et biophysica acta 2001;1526(2):141-6.
2001: Roberts S R; Knight M M; Lee D A; Bader D L
Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;90(4):1385-91.
2001: Bouten C V; Knight M M; Lee D A; Bade D L
Compressive deformation and damage of muscle cell subpopulations in a model system.
Annals of biomedical engineering 2001;29(2):153-63.
2000: Cacou C; Palmer D; Lee D A; Bader D L; Shelton J C
A system for monitoring the response of uniaxial strain on cell seeded collagen gels.
Medical engineering & physics 2000;22(5):327-33.
2000: Idowu B D; Knight M M; Bader D L; Lee D A
Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose.
The Histochemical journal 2000;32(3):165-74.
2000: Lee D A; Knight M M; Bolton J F; Idowu B D; Kayser M V; Bader D L
Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels.
Journal of biomechanics 2000;33(1):81-95.
2000: Lee D A; Noguchi T; Frean S P; Lees P; Bader D L
The influence of mechanical loading on isolated chondrocytes seeded in agarose constructs.
Biorheology 2000;37(1-2):149-61.
1998: Knight M M; Ghori S A; Lee D A; Bader D L
Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression.
Medical engineering & physics 1998;20(9):684-8.
1998: Lee D A; Noguchi T; Knight M M; O'Donnell L; Bentley G; Bader D L
Response of chondrocyte subpopulations cultured within unloaded and loaded agarose.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1998;16(6):726-33.
1998: Lee D A; Frean S P; Lees P; Bader D L
Dynamic mechanical compression influences nitric oxide production by articular chondrocytes seeded in agarose.
Biochemical and biophysical research communications 1998;251(2):580-5.
1998: Knight M M; Lee D A; Bader D L
The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose.
Biochimica et biophysica acta 1998;1405(1-3):67-77.
1997: Lee D A; Bader D L
Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1997;15(2):181-8.

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