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Edmund Lee

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Asian Continental Ancestry Group

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Genes & Molecular Sequences

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Pharmacogenetics

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Polymerase Chain Reaction

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Publications

TOP 3
Sin Chi Chew; Xiangai Chen; Edmund J D Lee; Wan-Teck Lim; Edwin Sandanaraj; Onkar Singh; Eng Huat Tan; Balram Chowbay
Influence of SLCO1B3 haplotype-tag SNPs on docetaxel disposition in Chinese nasopharyngeal cancer patients.
Sin-Chi Chew; Onkar Singh; Xiangai Chen; Rathi Devi Ramasamy; Tejal Kulkarni; Edmund J D Lee; Eng Huat Tan; Wan-Teck Lim; Balram Chowbay
The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients.
Joanne S L Lim; Xiang A Chen; Onkar Singh; Yoon S Yap; Raymond C H Ng; Nan Soon Wong; Mabel Wong; Edmund J D Lee; Balram Chowbay
Impact of CYP2D6, CYP3A5, CYP2C9 and CYP2C19 polymorphisms on tamoxifen pharmacokinetics in Asian breast cancer patients.

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2012: Sin Chi Chew; Xiangai Chen; Edmund J D Lee; Wan-Teck Lim; Edwin Sandanaraj; Onkar Singh; Eng Huat Tan; Balram Chowbay
Influence of SLCO1B3 haplotype-tag SNPs on docetaxel disposition in Chinese nasopharyngeal cancer patients.
British journal of clinical pharmacology 2012;73(4):606-18.
2011: Sin-Chi Chew; Onkar Singh; Xiangai Chen; Rathi Devi Ramasamy; Tejal Kulkarni; Edmund J D Lee; Eng Huat Tan; Wan-Teck Lim; Balram Chowbay
The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients.
Cancer chemotherapy and pharmacology 2011;67(6):1471-8.
2011: Joanne S L Lim; Xiang A Chen; Onkar Singh; Yoon S Yap; Raymond C H Ng; Nan Soon Wong; Mabel Wong; Edmund J D Lee; Balram Chowbay
Impact of CYP2D6, CYP3A5, CYP2C9 and CYP2C19 polymorphisms on tamoxifen pharmacokinetics in Asian breast cancer patients.
British journal of clinical pharmacology 2011;71(5):737-50.
2010: Chee-Seng Ku; Yudi Pawitan; Xueling Sim; Rick T H Ong; Mark Seielstad; Edmund J D Lee; Yik-Ying Teo; Kee-Seng Chia; Agus Salim
Genomic copy number variations in three Southeast Asian populations.
Human mutation 2010;31(7):851-7.
2010: Kimberly K Adkison; Soniya S Vaidya; Daniel Y Lee; Seok Hwee Koo; Linghui Li; Amar A Mehta; Annette S Gross; Joseph W Polli; Joan E Humphreys; Yu Lou; Edmund J D Lee
Oral sulfasalazine as a clinical BCRP probe substrate: pharmacokinetic effects of genetic variation (C421A) and pantoprazole coadministration.
Journal of pharmaceutical sciences 2010;99(2):1046-62.
2009: Yik-Ying Teo; Xueling Sim; Rick T H Ong; Adrian K S Tan; Jieming Chen; Erwin Tantoso; Kerrin S Small; Chee-Seng Ku; Edmund J D Lee; Mark Seielstad; Kee-Seng Chia
Singapore Genome Variation Project: a haplotype map of three Southeast Asian populations.
Genome research 2009;19(11):2154-62.
2008: Edwin Sandanaraj; Suman Lal; Viknesvaran Selvarajan; London Lucien Ooi; Zee-Wan Wong; Nan Soon Wong; Peter Cher Siang Ang; Edmund J D Lee; Balram Chowbay
PXR pharmacogenetics: association of haplotypes with hepatic CYP3A4 and ABCB1 messenger RNA expression and doxorubicin clearance in Asian breast cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(21):7116-26.
2008: Suman Lal; Edwin Sandanaraj; Zee-Wan Wong; Peter C S Ang; Nan Soon Wong; Edmund J D Lee; Balram Chowbay
CBR1 and CBR3 pharmacogenetics and their influence on doxorubicin disposition in Asian breast cancer patients.
Cancer science 2008;99(10):2045-54.
2008: Kimberly K Adkison; Soniya S Vaidya; Daniel Y Lee; Seok Hwee Koo; Linghui Li; Amar A Mehta; Annette Gross; Joseph W Polli; Yu Lou; Edmund J D Lee
The ABCG2 C421A polymorphism does not affect oral nitrofurantoin pharmacokinetics in healthy Chinese male subjects.
British journal of clinical pharmacology 2008;66(2):233-9.
2008: Suman Lal; Zee-Wan Wong; Edwin Sandanaraj; Xiaoqiang Xiang; Peter Cher Siang Ang; Edmund J D Lee; Balram Chowbay
Influence of ABCB1 and ABCG2 polymorphisms on doxorubicin disposition in Asian breast cancer patients.
Cancer science 2008;99(4):816-23.
2007: Seok Hwee Koo; Wee Siong Teo; Chi Keong Ching; Soh Ha Chan; Edmund J D Lee
Mutation screening in KCNQ1, HERG, KCNE1, KCNE2 and SCN5A genes in a long QT syndrome family.
Annals of the Academy of Medicine, Singapore 2007;36(6):394-8.
2007: K T Chong; W F Ho; Seok Hwee Koo; Peter Thompson; Edmund J D Lee
Distribution of the FcgammaRIIIa 176 F/V polymorphism amongst healthy Chinese, Malays and Asian Indians in Singapore.
British journal of clinical pharmacology 2007;63(3):328-32.
2006: Suman Lal; Srinivasa Rao Jada; Xiaoqiang Xiang; Wan-Teck Lim; Edmund J D Lee; Balram Chowbay
Pharmacogenetics of target genes across the warfarin pharmacological pathway.
Clinical pharmacokinetics 2006;45(12):1189-200.
2006: Zihua Wang; Pui-Hoon Sew; Helen Ambrose; Stephen Ryan; Samuel S Chong; Edmund J D Lee; Caroline G L Lee
Nucleotide sequence analyses of the MRP1 gene in four populations suggest negative selection on its coding region.
BMC genomics 2006;7():111.
2005: Balram Chowbay; Huihua Li; Machin David; Yin Bun Cheung; Edmund J D Lee
Meta-analysis of the influence of MDR1 C3435T polymorphism on digoxin pharmacokinetics and MDR1 gene expression.
British journal of clinical pharmacology 2005;60(2):159-71.
2005: Zihua Wang; Baoshuang Wang; Kun Tang; Edmund J D Lee; Samuel S Chong; Caroline G L Lee
A functional polymorphism within the MRP1 gene locus identified through its genomic signature of positive selection.
Human molecular genetics 2005;14(14):2075-87.
2005: Qingyu Zhou; Alex Sparreboom; Eng Huat Tan; Yin Bun Cheung; Ann Lee; Donald Poon; Edmund J D Lee; Balram Chowbay
Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancer.
British journal of clinical pharmacology 2005;59(4):415-24.
2005: Pai-Chung Gwee; Kun Tang; Pui Hoon Sew; Edmund J D Lee; Samuel S Chong; Caroline G L Lee
Strong linkage disequilibrium at the nucleotide analogue transporter ABCC5 gene locus.
Pharmacogenetics and genomics 2005;15(2):91-104.
2005: Balram Chowbay; Shufeng Zhou; Edmund J D Lee
An interethnic comparison of polymorphisms of the genes encoding drug-metabolizing enzymes and drug transporters: experience in Singapore.
Drug metabolism reviews 2005;37(2):327-78.
2004: Shufeng Zhou; Eli Chan; Shen-Quan Pan; Min Huang; Edmund J D Lee
Pharmacokinetic interactions of drugs with St John's wort.
Journal of psychopharmacology (Oxford, England) 2004;18(2):262-76.
2004: Kun Tang; Li-Peng Wong; Edmund J D Lee; Samuel S Chong; Caroline G L Lee
Genomic evidence for recent positive selection at the human MDR1 gene locus.
Human molecular genetics 2004;13(8):783-97.
2003: Chowbay Balram; A Sharma; C Sivathasan; Edmund J D Lee
Frequency of C3435T single nucleotide MDR1 genetic polymorphism in an Asian population: phenotypic-genotypic correlates.
British journal of clinical pharmacology 2003;56(1):78-83.
2003: Chowbay Balram; Qingyu Zhou; Yin Bun Cheung; Edmund J D Lee
CYP3A5*3 and *6 single nucleotide polymorphisms in three distinct Asian populations.
European journal of clinical pharmacology 2003;59(2):123-6.
2003: Balram Chowbay; Amarnath Sharma; Qing-Yu Zhou; Yin Bun Cheung; Edmund J D Lee
The modulation of irinotecan-induced diarrhoea and pharmacokinetics by three different classes of pharmacologic agents.
Oncology reports 2003;10(3):745-51.
2003: Pai-Chung Gwee; Kun Tang; John M Z Chua; Edmund J D Lee; Samuel S Chong; Caroline G L Lee
Simultaneous genotyping of seven single-nucleotide polymorphisms in the MDR1 gene by single-tube multiplex minisequencing.
Clinical chemistry 2003;49(4):672-6.
2003: Balram Chowbay; Sivathasan Cumaraswamy; Yin Bun Cheung; Qingyu Zhou; Edmund J D Lee
Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients.
Pharmacogenetics 2003;13(2):89-95.
2002: Kun Tang; Soo-Mun Ngoi; Pai-Chung Gwee; John M Z Chua; Edmund J D Lee; Samuel S Chong; Caroline G L Lee
Distinct haplotype profiles and strong linkage disequilibrium at the MDR1 multidrug transporter gene locus in three ethnic Asian populations.
Pharmacogenetics 2002;12(6):437-50.
2002: Chowbay Balram; Qing-Yu Zhou; Yin Bun Cheung; Edmund J D Lee
Influence of multiple dose activated charcoal on the disposition kinetics of irinotecan in rats.
Drug metabolism and drug interactions 2002;19(2):137-48.
2002: Chowbay Balram; Kanaga Sabapathy; Gao Fei; Kei-Siong Khoo; Edmund J D Lee
Genetic polymorphisms of UDP-glucuronosyltransferase in Asians: UGT1A1*28 is a common allele in Indians.
Pharmacogenetics 2002;12(1):81-3.
2001: Bin Zhao; Adeline Seow; Edmund J D Lee; Wee-Teng Poh; Ming Teh; Philip Eng; Yee-Tang Wang; Wan C Tan; Mimi C Yu; Hin-Peng Lee
Dietary isothiocyanates, glutathione S-transferase -M1, -T1 polymorphisms and lung cancer risk among Chinese women in Singapore.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001;10(10):1063-7.
2001: Adeline Seow; Bin Zhao; Edmund J D Lee; Wee-Teng Poh; Ming Teh; Philip Eng; Yee-Tang Wang; Wan C Tan; Hin-Peng Lee
Cytochrome P4501A2 (CYP1A2) activity and lung cancer risk: a preliminary study among Chinese women in Singapore.
Carcinogenesis 2001;22(4):673-7.
2000: Bin Zhao; Adeline Seow; Edmund J D Lee; Hin-Peng Lee
Correlation between acetylation phenotype and genotype in Chinese women.
European journal of clinical pharmacology 2000;56(9-10):689-92.
2000: J T Mah; J Y Wong; Edmund J D Lee
Pharmacogenetics: role in modifying drug dosage regimens.
Annals of the Academy of Medicine, Singapore 2000;29(5):628-32.
2000: J Y Wong; E S Seah; Edmund J D Lee
Pharmacogenetics: the molecular genetics of CYP2D6 dependent drug metabolism.
Annals of the Academy of Medicine, Singapore 2000;29(3):401-6.
1999: Adeline Seow; Bin Zhao; Wee-Teng Poh; Ming Teh; Philip Eng; Yee-Tang Wang; Wan C Tan; Edmund J D Lee; Hin-Peng Lee
NAT2 slow acetylator genotype is associated with increased risk of lung cancer among non-smoking Chinese women in Singapore.
Carcinogenesis 1999;20(9):1877-81.
1998: Edmund J D Lee; Bin Zhao; F Seow-Choen
Relationship between polymorphism of N-acetyltransferase gene and susceptibility to colorectal carcinoma in a Chinese population.
Pharmacogenetics 1998;8(6):513-7.
1998: Chian-Ming Low; Eric P H Yap; Edmund J D Lee
Characterization of polymorphisms IVS25AS-6A to G, C1237T and T3409C in the human angiotensin converting enzyme gene.
Pharmacogenetics 1998;8(4):361-4.
1998: Bin Zhao; Edmund J D Lee; P N Yeoh; N H Gong
Detection of mutations and polymorphism of N-acetyltransferase 1 gene in Indian, Malay and Chinese populations.
Pharmacogenetics 1998;8(4):299-304.
1997: Edmund J D Lee
Pharmacology and toxicology of chemical warfare agents.
Annals of the Academy of Medicine, Singapore 1997;26(1):104-7.
1995: Edmund J D Lee; J Y Wong; P N Yeoh; N H Gong
Glutathione S transferase-theta (GSTT1) genetic polymorphism among Chinese, Malays and Indians in Singapore.
Pharmacogenetics 1995;5(5):332-4.
1995: Bin Zhao; Edmund J D Lee; J Y Wong; P N Yeoh; N H Gong
Frequency of mutant CYP1A1, NAT2 and GSTM1 alleles in normal Indians and Malays.
Pharmacogenetics 1995;5(5):275-80.
1995: Edmund J D Lee
Polymorphic inhibition of human angiotensin I-converting enzyme by enalaprilat.
European journal of clinical pharmacology 1995;49(3):173-5.
1994: Edmund J D Lee; Bin Zhao; Shabbir M Moochhala; Sing Shang Ngoi
Frequency of mutant CYPIA1, NAT2 and GSTM1 alleles in a normal Chinese population.
Pharmacogenetics 1994;4(6):355-8.
1994: Edmund J D Lee; Ariff Bongso; A Kumar
Evaluation of inhalational anaesthetics on murine in vitro fertilization.
Annals of the Academy of Medicine, Singapore 1994;23(4):479-85.
1994: Edmund J D Lee
The angiotensin 1-converting enzyme genetic polymorphism is associated with altered substrate affinity.
Pharmacogenetics 1994;4(2):101-3.
1991: Edmund J D Lee
Stereochemistry in therapeutics--knowing what the left hand is doing.
Annals of the Academy of Medicine, Singapore 1991;20(3):359-61.
1991: Edmund J D Lee
Genetic polymorphisms in drug metabolism--its relevance to Asian populations.
Annals of the Academy of Medicine, Singapore 1991;20(1):56-60.
1989: Shabbir M Moochhala; Edmund J D Lee; G T Hu; O S Koh; G Becket
Effects of bromocriptine on hepatic cytochrome P-450 monooxygenase system.
Japanese journal of pharmacology 1989;49(2):285-91.
1989: G S Shahi; Shabbir M Moochhala; Edmund J D Lee; N P Das
Studies on the interactions of MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) with the cytochrome P-450 enzyme system--clues to a possible aetiological factor in Parkinson's disease.
Annals of the Academy of Medicine, Singapore 1989;18(1):93-7.
1989: Edmund J D Lee
NSAIDS--a consideration of their efficacy and toxicity.
Annals of the Academy of Medicine, Singapore 1989;18(1):12-4.
1988: Edmund J D Lee; Y P Nam; G N Hee
Oxidation phenotyping in Chinese and Malay populations.
Clinical and experimental pharmacology & physiology 1988;15(11):889-91.
1988: Edmund J D Lee
Diurnal effects on debrisoquine hydroxylation phenotyping.
European journal of clinical pharmacology 1988;35(4):441-2.