FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Larry Barak

Research Profile

Chemicals & Drugs

Anatomy

Cell Line

Physiology

Phenomena

Living Beings

Mouse

Genes & Molecular Sequences

Amino Acid Sequences

Co-author Network

Publications

TOP 3
Robert A Mook; Larry S Barak; Minyong Chen; Jiuyi Lu; H Kim Lyerly; Wei Chen
Small molecule modulators of Wnt/β-catenin signaling.
Jiuyi Lu; H Kim Lyerly; Xiu-Rong Ren; Jiangbo Wang; Larry S Barak; Minyong Chen; Wei Chen
Regulation of hedgehog signaling by myc-interacting zinc finger protein 1, miz1.
Jiangbo Wang; H Kim Lyerly; Larry S Barak; David M Gooden; Anchen Guo; Jiuyi Lu; Robert A Mook; Anthony Ribeiro; Wei Chen
Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Larry Barak (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Robert A Mook; Larry S Barak; Minyong Chen; Jiuyi Lu; H Kim Lyerly; Wei Chen
Small molecule modulators of Wnt/β-catenin signaling.
Bioorganic & medicinal chemistry letters 2013;23(7):2187-91.
2013: Jiuyi Lu; H Kim Lyerly; Xiu-Rong Ren; Jiangbo Wang; Larry S Barak; Minyong Chen; Wei Chen
Regulation of hedgehog signaling by myc-interacting zinc finger protein 1, miz1.
PloS one 2013;8(5):e63353.
2012: Jiangbo Wang; H Kim Lyerly; Larry S Barak; David M Gooden; Anchen Guo; Jiuyi Lu; Robert A Mook; Anthony Ribeiro; Wei Chen
Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.
Bioorganic & medicinal chemistry 2012;20(22):6751-7.
2012: Jiangbo Wang; Min Zhang; Shengli Zhao; Larry S Barak; Jonathan H Freedman; Jiuyi Lu; H Kim Lyerly; Robert A Mook; Wei Chen
The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks.
Toxicological sciences : an official journal of the Society of Toxicology 2012;128(2):517-23.
2012: Larry S Barak; Sean Peterson
Modeling of bias for the analysis of receptor signaling in biochemical systems.
Biochemistry 2012;51(6):1114-25.
2012: Ali Salahpour; Larry S Barak; Stefano Espinoza; Vincent Lam; Bernard Masri; Raul R Gainetdinov
BRET biosensors to study GPCR biology, pharmacology, and signal transduction.
Frontiers in endocrinology 2012;3():105.
2012: Xiu-Rong Ren; Neil Spector; Jiangbo Wang; Junping Wei; Wenle Xia; Larry S Barak; Kimberly Blackwell; Timothy M Clay; Erika Hamilton; Amy C Hobeika; Gangjun Lei; Jiuyi Lu; H Kim Lyerly; Michael A Morse; Takuya Osada; Wei Chen
Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells.
Breast cancer research : BCR 2012;14(3):R89.
2011: Stefano Espinoza; Larry S Barak; Marc G Caron; Bernard Masri; Mirko Messa; Ali Salahpour; Tatyana D Sotnikova; Raul R Gainetdinov
Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor.
Molecular pharmacology 2011;80(3):416-25.
2011: Jiangbo Wang; Robert A Mook; Larry S Barak; Wei Chen
Glucocorticoid hedgehog agonists in neurogenesis.
Vitamins and hormones 2011;87():207-15.
2011: Ali Salahpour; Larry S Barak
Visualizing receptor endocytosis and trafficking.
Methods in molecular biology (Clifton, N.J.) 2011;756():311-23.
2010: Wei Chen; Minyong Chen; Larry S Barak
Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach.
American journal of physiology. Gastrointestinal and liver physiology 2010;299(2):G293-300.
2010: Jiangbo Wang; Jiuyi Lu; Michael C Bond; Minyong Chen; Xiu-Rong Ren; H Kim Lyerly; Larry S Barak; Wei Chen
Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(20):9323-8.
2010: Tatyana D Sotnikova; Jean-Martin Beaulieu; Stefano Espinoza; Bernard Masri; Xiaodong Zhang; Ali Salahpour; Larry S Barak; Marc G Caron; Raul R Gainetdinov
The dopamine metabolite 3-methoxytyramine is a neuromodulator.
PloS one 2010;5(10):e13452.
2008: Melanie Philipp; Gregory B Fralish; Alison R Meloni; Wei Chen; Alyson W MacInnes; Larry S Barak; Marc G Caron
Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.
Molecular biology of the cell 2008;19(12):5478-89.
2008: Larry S Barak; Ali Salahpour; Xiaodong Zhang; Bernard Masri; Tatyana D Sotnikova; Amy J Ramsey; Jonathan D Violin; Robert J Lefkowitz; Marc G Caron; Raul R Gainetdinov
Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor.
Molecular pharmacology 2008;74(3):585-94.
2007: Sudha K Shenoy; Larry S Barak; Kunhong Xiao; Seungkirl Ahn; Magali Berthouze; arun shukla; Louis M Luttrell; Robert J Lefkowitz
Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation.
The Journal of biological chemistry 2007;282(40):29549-62.
2007: Sébastien Marion; Gregory B Fralish; Stephane Laporte; Marc G Caron; Larry S Barak
N-terminal tyrosine modulation of the endocytic adaptor function of the beta-arrestins.
The Journal of biological chemistry 2007;282(26):18937-44.
2006: Sébastien Marion; Robert H Oakley; Kyeong-Man Kim; Marc G Caron; Larry S Barak
A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors.
The Journal of biological chemistry 2006;281(5):2932-8.
2006: Larry S Barak; Jacqueline Gilchrist; Jeffrey M Becker; Kyeong-Man Kim
Relationship between the G protein signaling and homologous desensitization of G protein-coupled receptors.
Biochemical and biophysical research communications 2006;339(2):695-700.
2005: Tatyana D Sotnikova; Jean-Martin Beaulieu; Larry S Barak; William C Wetsel; Marc G Caron; Raul R Gainetdinov
Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease.
PLoS biology 2005;3(8):e271.
2005: Kyeong-Man Kim; Raul R Gainetdinov; Stephane Laporte; Marc G Caron; Larry S Barak
G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation.
The Journal of biological chemistry 2005;280(13):12774-80.
2004: Alyson M Wilbanks; Gregory B Fralish; Margaret L Kirby; Larry S Barak; Yin-Xiong Li; Marc G Caron
Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway.
Science (New York, N.Y.) 2004;306(5705):2264-7.
2004: Wei Chen; Xiu-Rong Ren; Christopher D Nelson; Larry S Barak; James Kenneth Chen; Philip A Beachy; Frederic J de Sauvage; Robert J Lefkowitz
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.
Science (New York, N.Y.) 2004;306(5705):2257-60.
2004: Kerry L Hildreth; Jiao-Hui Wu; Larry S Barak; Sabrina T Exum; Luke K Kim; Karsten Peppel; Neil J Freedman
Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor.
The Journal of biological chemistry 2004;279(40):41775-82.
2004: Laura M Bohn; Linda A Dykstra; R J Lefkowitz; Marc G Caron; Larry S Barak
Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery.
Molecular pharmacology 2004;66(1):106-12.
2003: Erik C Johnson; Laura M Bohn; Larry S Barak; Ryan T Birse; Dick R Nässel; Marc G Caron; Paul H Taghert
Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions.
The Journal of biological chemistry 2003;278(52):52172-8.
2003: Wei Chen; Derk ten Berge; Jeff Brown; Seungkirl Ahn; Liaoyuan A Hu; William E Miller; Marc G Caron; Larry S Barak; Roel Nusse; Robert J Lefkowitz
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.
Science (New York, N.Y.) 2003;301(5638):1391-4.
2003: Larry S Barak; Robert H Oakley; Michael A Shetzline
G protein-coupled receptor desensitization as a measure of signaling: modeling of arrestin recruitment to activated CCK-B receptors.
Assay and drug development technologies 2003;1(3):409-24.
2003: Larry S Barak; Alyson M Wilbanks; Marc G Caron
Constitutive desensitization: a new paradigm for g protein-coupled receptor regulation.
Assay and drug development technologies 2003;1(2):339-46.
2003: Mark D Richardson; Anastasia M Balius; Keisuke Yamaguchi; Emily R Freilich; Larry S Barak; Madan M Kwatra
Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize.
Journal of neurochemistry 2003;84(4):854-63.
2002: Alyson M Wilbanks; Stephane Laporte; Laura M Bohn; Larry S Barak; Marc G Caron
Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors.
Biochemistry 2002;41(40):11981-9.
2002: Sathyamangla V Naga Prasad; Stephane Laporte; Dean Chamberlain; Marc G Caron; Larry S Barak; Howard A Rockman
Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex.
The Journal of cell biology 2002;158(3):563-75.
2001: Kyeong-Man Kim; K J Valenzano; S R Robinson; W D Yao; Larry S Barak; Marc G Caron
Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins.
The Journal of biological chemistry 2001;276(40):37409-14.
2001: Robert H Oakley; Stephane Laporte; JA Holt; Larry S Barak; Marc G Caron
Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*.
The Journal of biological chemistry 2001;276(22):19452-60.
2001: Sathyamangla V Naga Prasad; Larry S Barak; Antonio Rapacciuolo; Marc G Caron; Howard A Rockman
Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration.
The Journal of biological chemistry 2001;276(22):18953-9.
2001: Larry S Barak; Robert H Oakley; Stephane Laporte; Marc G Caron
Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(1):93-8.
2000: Stephane Laporte; Robert H Oakley; JA Holt; Larry S Barak; Marc G Caron
The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits.
The Journal of biological chemistry 2000;275(30):23120-6.
2000: Robert H Oakley; Stephane Laporte; JA Holt; Marc G Caron; Larry S Barak
Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors.
The Journal of biological chemistry 2000;275(22):17201-10.
1999: Sara R Jones; James D Joseph; Larry S Barak; Marc G Caron; R Mark Wightman
Dopamine neuronal transport kinetics and effects of amphetamine.
Journal of neurochemistry 1999;73(6):2406-14.
1999: Robert H Oakley; Stephane Laporte; JA Holt; Larry S Barak; Marc G Caron
Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization.
The Journal of biological chemistry 1999;274(45):32248-57.
1999: Julia K L Walker; Richard T Premont; Larry S Barak; Marc G Caron; Michael A Shetzline
Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor.
The Journal of biological chemistry 1999;274(44):31515-23.
1999: Jian Zhang; Larry S Barak; Pieter H Anborgh; Stephane Laporte; Marc G Caron; Stephen S G Ferguson
Cellular trafficking of G protein-coupled receptor/beta-arrestin endocytic complexes.
The Journal of biological chemistry 1999;274(16):10999-1006.
1999: Stephane Laporte; Robert H Oakley; Jian Zhang; JA Holt; Stephen S G Ferguson; Marc G Caron; Larry S Barak
The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3712-7.
1999: Larry S Barak; Kengo Warabi; X Feng; Marc G Caron; Madan M Kwatra
Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor.
The Journal of biological chemistry 1999;274(11):7565-9.
1999: Larry S Barak; Jian Zhang; Stephen S G Ferguson; Stephane Laporte; Marc G Caron
Signaling, desensitization, and trafficking of G protein-coupled receptors revealed by green fluorescent protein conjugates.
Methods in enzymology 1999;302():153-71.
1999: Jian Zhang; Stephen S G Ferguson; P Y Law; Larry S Barak; Marc G Caron
Agonist-specific regulation of delta-opioid receptor trafficking by G protein-coupled receptor kinase and beta-arrestin.
Journal of receptor and signal transduction research 1999;19(1-4):301-13.
1998: Jian Zhang; Stephen S G Ferguson; Larry S Barak; S R Bodduluri; Stephane Laporte; P Y Law; Marc G Caron
Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):7157-62.
1998: Julie A Pitcher; RA Hall; Yehia A Daaka; Jian Zhang; Stephen S G Ferguson; S Hester; S Miller; Marc G Caron; Robert J Lefkowitz; Larry S Barak
The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin.
The Journal of biological chemistry 1998;273(20):12316-24.
1998: X Feng; Jian Zhang; Larry S Barak; T Meyer; Marc G Caron; Yusuf A Hannun
Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization.
The Journal of biological chemistry 1998;273(17):10755-62.
1998: RA Hall; Richard T Premont; Chi-Wing Chow; Jeremy T Blitzer; Julie A Pitcher; Audrey Claing; RH Stoffel; Larry S Barak; Shirish Shenolikar; Edward J Weinman; S Grinstein; Robert J Lefkowitz
The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.
Nature 1998;392(6676):626-30.
1998: Stephen S G Ferguson; Jian Zhang; Larry S Barak; Marc G Caron
Role of beta-arrestins in the intracellular trafficking of G-protein-coupled receptors.
Advances in pharmacology (San Diego, Calif.) 1998;42():420-4.
1997: Larry S Barak; Stephen S G Ferguson; Jian Zhang; Marc G Caron
A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation.
The Journal of biological chemistry 1997;272(44):27497-500.
1997: Jian Zhang; Larry S Barak; K E Winkler; Marc G Caron; Stephen S G Ferguson
A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types.
The Journal of biological chemistry 1997;272(43):27005-14.
1997: L Ménard; Stephen S G Ferguson; Jian Zhang; Fang-Tsyr Lin; Robert J Lefkowitz; Marc G Caron; Larry S Barak
Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization.
Molecular pharmacology 1997;51(5):800-8.
1997: Larry S Barak; Stephen S G Ferguson; Jian Zhang; C Martenson; T Meyer; Marc G Caron
Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate.
Molecular pharmacology 1997;51(2):177-84.
1997: Jian Zhang; Stephen S G Ferguson; Larry S Barak; M J Aber; Bruno GIROS; Robert J Lefkowitz; Marc G Caron
Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization.
Receptors & channels 1997;5(3-4):193-9.
1996: Stephen S G Ferguson; Jian Zhang; Larry S Barak; Marc G Caron
G-protein-coupled receptor kinases and arrestins: regulators of G-protein-coupled receptor sequestration.
Biochemical Society transactions 1996;24(4):953-9.
1996: Stephen S G Ferguson; Larry S Barak; Jian Zhang; Marc G Caron
G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins.
Canadian journal of physiology and pharmacology 1996;74(10):1095-110.
1996: Jian Zhang; Stephen S G Ferguson; Larry S Barak; L Ménard; Marc G Caron
Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization.
The Journal of biological chemistry 1996;271(31):18302-5.
1996: L Ménard; Stephen S G Ferguson; Larry S Barak; L Bertrand; Richard T Premont; A M Colapietro; R J Lefkowitz; Marc G Caron
Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.
Biochemistry 1996;35(13):4155-60.
1996: Stephen S G Ferguson; W E Downey; A M Colapietro; Larry S Barak; L Ménard; Marc G Caron
Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization.
Science (New York, N.Y.) 1996;271(5247):363-6.
1995: Larry S Barak; L Ménard; Stephen S G Ferguson; A M Colapietro; Marc G Caron
The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor.
Biochemistry 1995;34(47):15407-14.
1995: Stephen S G Ferguson; L Ménard; Larry S Barak; Walter J Koch; A M Colapietro; Marc G Caron
Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1.
The Journal of biological chemistry 1995;270(42):24782-9.
1995: Larry S Barak; Marc G Caron
Modeling of sequestration and down regulation in cells containing beta2-adrenergic receptors.
Journal of receptor and signal transduction research 1995;15(1-4):677-90.
1994: Larry S Barak; M Tiberi; N J Freedman; Madan M Kwatra; R J Lefkowitz; Marc G Caron
A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.
The Journal of biological chemistry 1994;269(4):2790-5.