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Frank Lee

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Daisheng Song; Patrick R Arsenault; Katherine J Heaton-Johnson; Lin-Sheng Li; Stephen R Master; Frank S Lee
Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway.
Melanie J Percy; Alexandre C Pereira; Paulo C J L Santos; Mary Frances McMullin; Jane Mercieca; Yu Jin Chung; Carla L Dinardo; Guilherme H H Fonseca; Sandra F M Gualandro; Claire Harrison; A Victor Hoffbrand; Terence R J Lappin; Frank S Lee
Two new mutations in the HIF2A gene associated with erythrocytosis.
Daisheng Song; Frank S Lee
Mouse knock-out of IOP1 protein reveals its essential role in mammalian cytosolic iron-sulfur protein biogenesis.

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All Publications

2013: Daisheng Song; Patrick R Arsenault; Katherine J Heaton-Johnson; Lin-Sheng Li; Stephen R Master; Frank S Lee
Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway.
The Journal of biological chemistry 2013;288(14):9662-74.
2012: Melanie J Percy; Alexandre C Pereira; Paulo C J L Santos; Mary Frances McMullin; Jane Mercieca; Yu Jin Chung; Carla L Dinardo; Guilherme H H Fonseca; Sandra F M Gualandro; Claire Harrison; A Victor Hoffbrand; Terence R J Lappin; Frank S Lee
Two new mutations in the HIF2A gene associated with erythrocytosis.
American journal of hematology 2012;87(4):439-42.
2011: Daisheng Song; Frank S Lee
Mouse knock-out of IOP1 protein reveals its essential role in mammalian cytosolic iron-sulfur protein biogenesis.
The Journal of biological chemistry 2011;286(18):15797-805.
2011: Frank S Lee; Melanie J Percy
The HIF pathway and erythrocytosis.
Annual review of pathology 2011;6():165-92.
2010: Xiping Li; Scott Sutherland; Kotaro Takeda; Guo-Hua Fong; Frank S Lee
Integrity of the prolyl hydroxylase domain protein 2:erythropoietin pathway in aging mice.
Blood cells, molecules & diseases 2010;45(1):9-19.
2009: Daisheng Song; Zheng Tu; Frank S Lee
Human ISCA1 interacts with IOP1/NARFL and functions in both cytosolic and mitochondrial iron-sulfur protein biogenesis.
The Journal of biological chemistry 2009;284(51):35297-307.
2009: Paul W Furlow; Melanie J Percy; Scott Sutherland; Charlene Bierl; Mary Frances McMullin; Stephen R Master; Terence R J Lappin; Frank S Lee
Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline.
The Journal of biological chemistry 2009;284(14):9050-8.
2008: Frank S Lee
Genetic causes of erythrocytosis and the oxygen-sensing pathway.
Blood reviews 2008;22(6):321-32.
2008: Melanie J Percy; Frank S Lee
Familial erythrocytosis: molecular links to red blood cell control.
Haematologica 2008;93(7):963-7.
2008: Melanie J Percy; Philip A Beer; Gavin Campbell; Ad W Dekker; Anthony R Green; David Oscier; M Glenn Rainey; Richard van Wijk; Marion Wood; Terence R J Lappin; Mary Frances McMullin; Frank S Lee
Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis.
Blood 2008;111(11):5400-2.
2008: Daisheng Song; Frank S Lee
A role for IOP1 in mammalian cytosolic iron-sulfur protein biogenesis.
The Journal of biological chemistry 2008;283(14):9231-8.
2008: Kotaro Takeda; Hector L Aguila; Nehal S Parikh; Xiping Li; Katie Lamothe; Li-Juan Duan; Hiromi Takeda; Frank S Lee; Guo-Hua Fong
Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins.
Blood 2008;111(6):3229-35.
2008: Melanie J Percy; Paul W Furlow; Guy S Lucas; Xiping Li; Terence R J Lappin; Mary Frances McMullin; Frank S Lee
A gain-of-function mutation in the HIF2A gene in familial erythrocytosis.
The New England journal of medicine 2008;358(2):162-8.
2007: Melanie J Percy; Paul W Furlow; Philip A Beer; Terence R J Lappin; Mary Frances McMullin; Frank S Lee
A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove.
Blood 2007;110(6):2193-6.
2007: Jianhe Huang; Daisheng Song; Adrian Flores; Quan Zhao; Sharon M Mooney; Leslie M Shaw; Frank S Lee
IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activity.
The Biochemical journal 2007;401(1):341-52.
2006: Antonio Ferrante; Brenton S Robinson; Harmeet Singh; Hubertus P A Jersmann; judith ferrante; Zhi H Huang; Neil A Trout; Michael J Pitt; Deborah A Rathjen; Christopher J Easton; Alf Poulos; Rolf H Prager; Frank S Lee; Charles S T Hii
A novel beta-oxa polyunsaturated fatty acid downregulates the activation of the IkappaB kinase/nuclear factor kappaB pathway, inhibits expression of endothelial cell adhesion molecules, and depresses inflammation.
Circulation research 2006;99(1):34-41.
2006: Frank S Lee; Melanie J Percy; Mary Frances McMullin
Oxygen sensing: recent insights from idiopathic erythrocytosis.
Cell cycle (Georgetown, Tex.) 2006;5(9):941-5.
2006: Melanie J Percy; Quan Zhao; Adrian Flores; Claire Harrison; Terence R J Lappin; Patrick H Maxwell; Mary Frances McMullin; Frank S Lee
A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(3):654-9.
2003: Zheng Tu; Frank S Lee
Subdomain VIII is a specificity-determining region in MEKK1.
The Journal of biological chemistry 2003;278(48):48498-505.
2003: Melanie J Percy; Sharon M Mooney; Mary Frances McMullin; Adrian Flores; Terence R J Lappin; Frank S Lee
A common polymorphism in the oxygen-dependent degradation (ODD) domain of hypoxia inducible factor-1alpha (HIF-1alpha) does not impair Pro-564 hydroxylation.
Molecular cancer 2003;2():31.
2003: Steven E Raper; Narendra Chirmule; Frank S Lee; Nelson A Wivel; Adam Bagg; Guang-Ping Gao; James M Wilson; Mark L Batshaw
Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer.
Molecular genetics and metabolism 2003;80(1-2):148-58.
2003: Jianhe Huang; Zheng Tu; Frank S Lee
Mutations in protein kinase subdomain X differentially affect MEKK2 and MEKK1 activity.
Biochemical and biophysical research communications 2003;303(2):532-40.
2003: Quan Zhao; Frank S Lee
The transcriptional activity of the APP intracellular domain-Fe65 complex is inhibited by activation of the NF-kappaB pathway.
Biochemistry 2003;42(12):3627-34.
2003: Zheng Tu; Sharon M Mooney; Frank S Lee
A subdomain of MEKK1 that is critical for binding to MKK4.
Cellular signalling 2003;15(1):65-77.
2002: Jianhe Huang; Quan Zhao; Sharon M Mooney; Frank S Lee
Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.
The Journal of biological chemistry 2002;277(42):39792-800.
2001: F Yu; S B White; Quan Zhao; Frank S Lee
HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9630-5.
2001: Zheng Tu; V R Kelley; T Collins; Frank S Lee
I kappa B kinase is critical for TNF-alpha-induced VCAM1 gene expression in renal tubular epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(11):6839-46.
2001: F Yu; S B White; Quan Zhao; Frank S Lee
Dynamic, site-specific interaction of hypoxia-inducible factor-1alpha with the von Hippel-Lindau tumor suppressor protein.
Cancer research 2001;61(10):4136-42.
1999: Quan Zhao; Frank S Lee
Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta.
The Journal of biological chemistry 1999;274(13):8355-8.
1998: Frank S Lee; RT Peters; L C Dang; Tom Maniatis
MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9319-24.
1997: Frank S Lee; J Hagler; Zhijian J Chen; Tom Maniatis
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway.
Cell 1997;88(2):213-22.
1993: Frank S Lee; Bert L Vallee
Structure and action of mammalian ribonuclease (angiogenin) inhibitor.
Progress in nucleic acid research and molecular biology 1993;44():1-30.
1990: Frank S Lee; Bert L Vallee
Kinetic characterization of two active mutants of placental ribonuclease inhibitor that lack internal repeats.
Biochemistry 1990;29(28):6633-8.
1990: Frank S Lee; Bert L Vallee
Modular mutagenesis of human placental ribonuclease inhibitor, a protein with leucine-rich repeats.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(5):1879-83.
1989: Frank S Lee; Bert L Vallee
Characterization of ribonucleolytic activity of angiogenin towards tRNA.
Biochemical and biophysical research communications 1989;161(1):121-6.
1989: Frank S Lee; Bert L Vallee
Binding of placental ribonuclease inhibitor to the active site of angiogenin.
Biochemistry 1989;28(8):3556-61.
1989: Frank S Lee; Bert L Vallee
Expression of human placental ribonuclease inhibitor in Escherichia coli.
Biochemical and biophysical research communications 1989;160(1):115-20.
1989: Frank S Lee; Robert Shapiro; Bert L Vallee
Tight-binding inhibition of angiogenin and ribonuclease A by placental ribonuclease inhibitor.
Biochemistry 1989;28(1):225-30.
1989: Frank S Lee; D S Auld; Bert L Vallee
Tryptophan fluorescence as a probe of placental ribonuclease inhibitor binding to angiogenin.
Biochemistry 1989;28(1):219-24.
1988: Frank S Lee; E A Fox; H M Zhou; D J Strydom; Bert L Vallee
Primary structure of human placental ribonuclease inhibitor.
Biochemistry 1988;27(23):8545-53.
1987: R Bicknell; B Holmquist; Frank S Lee; M T Martin; James F Riordan
Electronic spectroscopy of cobalt angiotensin converting enzyme and its inhibitor complexes.
Biochemistry 1987;26(23):7291-7.