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Gyun Min Lee
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Research Profile (preview)
Anatomy
Living Beings
Chemicals & Drugs
Procedures
Physiology
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Network (preview)
10
Kim, No Soo
10
Koh, Gou Young
9
Yoon, Sung Kwan
8
Chung, Joo Young
6
Hwang, Sun Ok
6
Kim, Sung Hyun
6
Kim, Min Soo
6
Sung, Yun Hee
6
Hwang, Su-Jeong
5
Lee, Moon Sue
5
Kim, Kyung-Tae
5
Choi, Han-Ho
4
Cho, Chung-Hyun
4
Kim, Yeon-Gu
4
Ryu, JS
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All Publications
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2009: Han Young Kue; Koo Tai Young; Lee Gyun Min
Enhanced interferon-beta production by CHO cells through elevated osmolality and reduced culture temperature.
Biotechnology progress 2009;25(5):1440-7.
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2009: Ju Hye Kyung; Hwang Su-Jeong; Jeon Choon-Ju; Lee Gyun Min; Yoon Sung Kwan
Use of NaCl prevents aggregation of recombinant COMP-angiopoietin-1 in Chinese hamster ovary cells.
Journal of biotechnology 2009;143(2):145-50.
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2009: Kim Won Hee; Kim Jung-Seop; Yoon Yeup; Lee Gyun Min
Effect of Ca2+ and Mg2+ concentration in culture medium on the activation of recombinant factor IX produced in Chinese hamster ovary cells.
Journal of biotechnology 2009;142(3-4):275-8.
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2009: Kim Yeon-Gu; Kim Jee Yon; Mohan Chaya; Lee Gyun Min
Effect of Bcl-xL overexpression on apoptosis and autophagy in recombinant Chinese hamster ovary cells under nutrient-deprived condition.
Biotechnology and bioengineering 2009;103(4):757-66.
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2009: Kim Sung Hyun; Lee Gyun Min
Development of serum-free medium supplemented with hydrolysates for the production of therapeutic antibodies in CHO cell cultures using design of experiments.
Applied microbiology and biotechnology 2009;83(4):639-48.
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2009: Jang Cholsoon; Koh Young Jun; Lim Nam Kyu; Kang Hyun Jung; Kim Duk Hoon; Park Sung Kwang; Lee Gyun Min; Jeon Choon Ju; Koh Gou Young
Angiopoietin-2 exocytosis is stimulated by sphingosine-1-phosphate in human blood and lymphatic endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(3):401-7.
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2009: Kim Yeon-Gu; Lee Gyun Min
Bcl-xL overexpression does not enhance specific erythropoietin productivity of recombinant CHO cells grown at 33 degrees C and 37 degrees C.
Biotechnology progress 2009;25(1):252-6.
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2009: Mohan Chaya; Lee Gyun Min
Calnexin overexpression sensitizes recombinant CHO cells to apoptosis induced by sodium butyrate treatment.
Cell stress & chaperones 2009;14(1):49-60.
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2008: Hwang Su-Jeong; Kim Sung Hyun; Kim Hak-Zoo; Steinmetz Michel O; Koh Gou Young; Lee Gyun Min
High-level expression and purification of a designed angiopoietin-1 chimeric protein, COMP-Ang1, produced in Chinese hamster ovary cells.
The protein journal 2008;27(5):319-26.
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2008: Kim Min Soo; Lee Gyun Min
Use of Flp-mediated cassette exchange in the development of a CHO cell line stably producing erythropoietin.
Journal of microbiology and biotechnology 2008;18(7):1342-51.
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2008: Mohan Chaya; Kim Yeon-Gu; Koo Jane; Lee Gyun Min
Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells.
Biotechnology journal 2008;3(5):624-30.
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2008: Baik Jong Youn; Joo Eun Jin; Kim Young Hwan; Lee Gyun Min
Limitations to the comparative proteomic analysis of thrombopoietin producing Chinese hamster ovary cells treated with sodium butyrate.
Journal of biotechnology 2008;133(4):461-8.
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2008: Hwang Sun Ok; Lee Gyun Min
Nutrient deprivation induces autophagy as well as apoptosis in Chinese hamster ovary cell culture.
Biotechnology and bioengineering 2008;99(3):678-85.
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2008: Hwang Sun Ok; Lee Gyun Min
Autophagy and apoptosis in Chinese hamster ovary cell culture.
Autophagy 2008;4(1):70-2.
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2007: Mohan Chaya; Park Soon Hye; Chung Joo Young; Lee Gyun Min
Effect of doxycycline-regulated protein disulfide isomerase expression on the specific productivity of recombinant CHO cells: thrombopoietin and antibody.
Biotechnology and bioengineering 2007;98(3):611-5.
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2007: Sung Yun Hee; Lee Jae Seong; Park Soon Hye; Koo Jane; Lee Gyun Min
Influence of co-down-regulation of caspase-3 and caspase-7 by siRNAs on sodium butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin.
Metabolic engineering 2007;9(5-6):452-64.
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2007: Kim Sung Hyun; Lee Gyun Min
Functional expression of human pyruvate carboxylase for reduced lactic acid formation of Chinese hamster ovary cells (DG44).
Applied microbiology and biotechnology 2007;76(3):659-65.
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2007: Jeon Min Kyoung; Lee Gyun Min
Correlation between enhancing effect of sodium butyrate on specific productivity and mRNA transcription level in recombinant Chinese hamster ovary cells producing antibody.
Journal of microbiology and biotechnology 2007;17(6):1036-40.
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2007: Kim Hyun Sung; Lee Gyun Min
Differences in optimal pH and temperature for cell growth and antibody production between two Chinese hamster ovary clones derived from the same parental clone.
Journal of microbiology and biotechnology 2007;17(5):712-20.
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2007: Hwang Su-Jeong; Kim Hak-Zoo; Koh Gou Young; Lee Gyun Min
Expression and purification of recombinant human angiopoietin-1 produced in Chinese hamster ovary cells.
In vitro cellular & developmental biology. Animal 2007;43(5-6):162-7.
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2007: Hong Jong Kwang; Kim Yeon-Gu; Yoon Sung Kwan; Lee Gyun Min
Down-regulation of cold-inducible RNA-binding protein does not improve hypothermic growth of Chinese hamster ovary cells producing erythropoietin.
Metabolic engineering 2007;9(2):208-16.
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2007: Kim Sung Hyun; Lee Gyun Min
Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin.
Applied microbiology and biotechnology 2007;74(1):152-9.
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2007: Kim Min Soo; Kim Won Hee; Lee Gyun Min
A simple analysis system for the estimation of recombination efficiency using fluorescence-activated cell sorting.
Journal of biotechnology 2007;127(3):373-84.
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2006: Jun Seung Chul; Kim Min Soo; Hong Hyo Jeong; Lee Gyun Min
Limitations to the development of humanized antibody producing Chinese hamster ovary cells using glutamine synthetase-mediated gene amplification.
Biotechnology progress 2006;22(3):770-80.
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2006: Yoon Sung Kwan; Hong Jong Kwang; Choo Seung Ho; Song Ji Yong; Park Hong Woo; Lee Gyun Min
Adaptation of Chinese hamster ovary cells to low culture temperature: cell growth and recombinant protein production.
Journal of biotechnology 2006;122(4):463-72.
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2006: Baik Jong Youn; Lee Moon Sue; An So Ra; Yoon Sung Kwan; Joo Eun Jin; Kim Young Hwan; Park Hong Woo; Lee Gyun Min
Initial transcriptome and proteome analyses of low culture temperature-induced expression in CHO cells producing erythropoietin.
Biotechnology and bioengineering 2006;93(2):361-71.
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2006: Kwon Ryuk-Jun; Kim Seong Keun; Lee Seung-Il; Hwang Su-Jeong; Lee Gyun Min; Kim Jin-Soo; Seol Wongi
Artificial transcription factors increase production of recombinant antibodies in Chinese hamster ovary cells.
Biotechnology letters 2006;28(1):9-15.
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2005: Jun Seung Chul; Kim Min Soo; Baik Jong Youn; Hwang Sun Ok; Lee Gyun Min
Selection strategies for the establishment of recombinant Chinese hamster ovary cell line with dihydrofolate reductase-mediated gene amplification.
Applied microbiology and biotechnology 2005;69(2):162-9.
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2005: Sung Yun Hee; Hwang Su-Jeong; Lee Gyun Min
Influence of down-regulation of caspase-3 by siRNAs on sodium-butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin.
Metabolic engineering 2005;7(5-6):457-66.
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2005: Cho Chung-Hyun; Kim Kyung Eun; Byun Jonghoe; Jang Hyung-Suk; Kim Duk-Kyung; Baluk Peter; Baffert Fabienne; Lee Gyun Min; Mochizuki Naoki; Kim Jin; Jeon Byeong Hwa; McDonald Donald M; Koh Gou Young
Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow.
Circulation research 2005;97(1):86-94.
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2005: Kim Kyung-Tae; Choi Han-Ho; Steinmetz Michel O; Maco Bohumil; Kammerer Richard A; Ahn So Young; Kim Hak-Zoo; Lee Gyun Min; Koh Gou Young
Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2.
The Journal of biological chemistry 2005;280(20):20126-31.
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2005: Ryu Ju Hee; Kim Min Soo; Lee Gyun Min; Choi Cha Yong; Kim Byung-Soo
The enhancement of recombinant protein production by polymer nanospheres in cell suspension culture.
Biomaterials 2005;26(14):2173-81.
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2005: Saharinen Pipsa; Kerkelä Katja; Ekman Niklas; Marron Marie; Brindle Nicholas; Lee Gyun Min; Augustin Hellmut; Koh Gou Young; Alitalo Kari
Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2.
The Journal of cell biology 2005;169(2):239-43.
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2005: Hwang Su-Jeong; Choi Han Ho; Kim Kyung-Tae; Hong Hyo Jeong; Koh Gou Young; Lee Gyun Min
Expression and purification of recombinant human angiopoietin-2 produced in Chinese hamster ovary cells.
Protein expression and purification 2005;39(2):175-83.
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2005: Yoon Sung Kwan; Choi Sang Lim; Song Ji Yong; Lee Gyun Min
Effect of culture pH on erythropoietin production by Chinese hamster ovary cells grown in suspension at 32.5 and 37.0 degrees C.
Biotechnology and bioengineering 2005;89(3):345-56.
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2005: Sung Yun Hee; Lee Gyun Min
Enhanced human thrombopoietin production by sodium butyrate addition to serum-free suspension culture of bcl-2-overexpressing CHO cells.
Biotechnology progress 2005;21(1):50-7.
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2004: Yoon Sung Kwan; Hwang Sun Ok; Lee Gyun Min
Enhancing effect of low culture temperature on specific antibody productivity of recombinant Chinese hamster ovary cells: clonal variation.
Biotechnology progress 2004;20(6):1683-8.
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2004: Park Min Tae; Lee Myung Seop; Kim Sung Hyun; Jo Eui-Cheol; Lee Gyun Min
Influence of culture passages on growth kinetics and adenovirus vector production for gene therapy in monolayer and suspension cultures of HEK 293 cells.
Applied microbiology and biotechnology 2004;65(5):553-8.
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2004: Sung Yun Hee; Song Yeon Jung; Lim Seung Wook; Chung Joo Young; Lee Gyun Min
Effect of sodium butyrate on the production, heterogeneity and biological activity of human thrombopoietin by recombinant Chinese hamster ovary cells.
Journal of biotechnology 2004;112(3):323-35.
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2004: Lee Hyuek Jong; Cho Chung-Hyun; Hwang Su-Jeong; Choi Han-Ho; Kim Kyung-Tae; Ahn So Young; Kim Ju-Hyun; Oh Jong-Lark; Lee Gyun Min; Koh Gou Young
Biological characterization of angiopoietin-3 and angiopoietin-4.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(11):1200-8.
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2004: Yoon Sung Kwan; Hong Jong Kwang; Lee Gyun Min
Effect of simultaneous application of stressful culture conditions on specific productivity and heterogeneity of erythropoietin in Chinese hamster ovary cells.
Biotechnology progress 2004;20(4):1293-6.
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2004: Park Min Tae; Hwang Su-Jeong; Lee Gyun Min
Flow cytometric application of helper adenovirus (HAd) containing GFP gene flanked by two parallel loxP sites to evaluation of 293 cre-complementing cell line and monitoring of HAd in Gutless Ad production.
Biotechnology progress 2004;20(3):913-20.
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2004: Cho Chung-Hyun; Kammerer Richard A; Lee Hyuek Jong; Yasunaga Kunio; Kim Kyung-Tae; Choi Han-Ho; Kim Won; Kim Sung Hyun; Park Sung Kwang; Lee Gyun Min; Koh Gou Young
Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5553-8.
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2004: Cho Chung-Hyun; Kammerer Richard A; Lee Hyuek Jong; Steinmetz Michel O; Ryu Young Shin; Lee Sung Ho; Yasunaga Kunio; Kim Kyung-Tae; Kim Injune; Choi Han-Ho; Kim Won; Kim Sung Hyun; Park Sung Kwang; Lee Gyun Min; Koh Gou Young
COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5547-52.
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2004: Chung Joo Young; Lim Seung Wook; Hong Yeon Joo; Hwang Sun Ok; Lee Gyun Min
Effect of doxycycline-regulated calnexin and calreticulin expression on specific thrombopoietin productivity of recombinant Chinese hamster ovary cells.
Biotechnology and bioengineering 2004;85(5):539-46.
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2004: Sung Y H; Lim S W; Chung J Y; Lee G M
Yeast hydrolysate as a low-cost additive to serum-free medium for the production of human thrombopoietin in suspension cultures of Chinese hamster ovary cells.
Applied microbiology and biotechnology 2004;63(5):527-36.
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2003: Lee Moon Sue; Kim Kyoung Wook; Kim Young Hwan; Lee Gyun Min
Proteome analysis of antibody-expressing CHO cells in response to hyperosmotic pressure.
Biotechnology progress 2003;19(6):1734-41.
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2003: Yoon Sung Kwan; Kim Sung Hyun; Lee Gyun Min
Effect of low culture temperature on specific productivity and transcription level of anti-4-1BB antibody in recombinant Chinese hamster ovary cells.
Biotechnology progress 2003;19(4):1383-6.
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2003: Lee Suk Kyoo; Lee Gyun Min
Development of apoptosis-resistant dihydrofolate reductase-deficient Chinese hamster ovary cell line.
Biotechnology and bioengineering 2003;82(7):872-6.
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2003: Yoon Sung Kwan; Song Ji Yong; Lee Gyun Min
Effect of low culture temperature on specific productivity, transcription level, and heterogeneity of erythropoietin in Chinese hamster ovary cells.
Biotechnology and bioengineering 2003;82(3):289-98.
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2003: Hwang Sun Ok; Chung Joo Young; Lee Gyun Min
Effect of doxycycline-regulated ERp57 expression on specific thrombopoietin productivity of recombinant CHO cells.
Biotechnology progress 2003;19(1):179-84.
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2002: Kim Min Soo; Kim No Soo; Sung Yun Hee; Lee Gyun Min
Biphasic culture strategy based on hyperosmotic pressure for improved humanized antibody production in Chinese hamster ovary cell culture.
In vitro cellular & developmental biology. Animal 2002;38(6):314-9.
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2002: Kim No Soo; Lee Gyun Min
Response of recombinant Chinese hamster ovary cells to hyperosmotic pressure: effect of Bcl-2 overexpression.
Journal of biotechnology 2002;95(3):237-48.
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2002: Kim No Soo; Lee Gyun Min
Inhibition of sodium butyrate-induced apoptosis in recombinant Chinese hamster ovary cells by constitutively expressing antisense RNA of caspase-3.
Biotechnology and bioengineering 2002;78(2):217-28.
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2002: Lee Gyun Min; Fong Stephen S; Oh Duk Jae; Francis Karl; Palsson Bernhard O
Characterization and efficacy of PKH26 as a probe to study the replication history of the human hematopoietic KG1a progenitor cell line.
In vitro cellular & developmental biology. Animal 2002;38(2):90-6.
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2001: Ryu J S; Lee M S; Lee G M
Effects of cloned gene dosage on the response of recombinant CHO cells to hyperosmotic pressure in regard to cell growth and antibody production.
Biotechnology progress 2001;17(6):993-9.
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2001: Lee M S; Lee G M
Effect of hypoosmotic pressure on cell growth and antibody production in recombinant Chinese hamster ovary cell culture.
Cytotechnology 2001;36(1-3):61-9.
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2001: Park M T; Lee M S; Choi J Y; Kim S C; Lee G M
Orthophosphate anion enhances the stability and activity of endoxylanase from Bacillus sp.
Biotechnology and bioengineering 2001;72(4):434-40.
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2001: Kim N S; Byun T H; Lee G M
Key determinants in the occurrence of clonal variation in humanized antibody expression of cho cells during dihydrofolate reductase mediated gene amplification.
Biotechnology progress 2001;17(1):69-75.
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2000: Chung J Y; Kim T K; Lee G M
Morphological selection of parental Chinese hamster ovary cell clones exhibiting high-level expression of recombinant protein.
BioTechniques 2000;29(4):768-7O, 762, 74.
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2000: Ryu J S; Kim T K; Chung J Y; Lee G M
Osmoprotective effect of glycine betaine on foreign protein production in hyperosmotic recombinant chinese hamster ovary cell cultures differs among cell lines.
Biotechnology and bioengineering 2000;70(2):167-75.
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2000: Kim T K; Ryu J S; Chung J Y; Kim M S; Lee G M
Osmoprotective effect of glycine betaine on thrombopoietin production in hyperosmotic Chinese hamster ovary cell culture: clonal variations.
Biotechnology progress 2000;16(5):775-81.
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2000: Lee M S; Lee G M
Hyperosmotic pressure enhances immunoglobulin transcription rates and secretion rates of KR12H-2 transfectoma.
Biotechnology and bioengineering 2000;68(3):260-8.
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2000: Kim N S; Lee G M
Overexpression of bcl-2 inhibits sodium butyrate-induced apoptosis in Chinese hamster ovary cells resulting in enhanced humanized antibody production.
Biotechnology and bioengineering 2000;71(3):184-93.
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1999: Kim S J; Lee G M
Cytogenetic analysis of chimeric antibody-producing CHO cells in the course of dihydrofolate reductase-mediated gene amplification and their stability in the absence of selective pressure.
Biotechnology and bioengineering 1999;64(6):741-9.
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1999: Kim E J; Kim N S; Lee G M
Development of a serum-free medium for dihydrofolate reductase-deficient Chinese hamster ovary cells (DG44) using a statistical design: beneficial effect of weaning of cells.
In vitro cellular & developmental biology. Animal 1999;35(4):178-82.
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1999: Lee G M; Kim E J; Kim N S; Yoon S K; Ahn Y H; Song J Y
Development of a serum-free medium for the production of erythropoietin by suspension culture of recombinant Chinese hamster ovary cells using a statistical design.
Journal of biotechnology 1999;69(2-3):85-93.
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1999: Ryu J S; Lee G M
Application of hypoosmolar medium to fed-batch culture of hybridoma cells for improvement of culture longevity.
Biotechnology and bioengineering 1999;62(1):120-3.
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1998: Kim N S; Kim S J; Lee G M
Clonal variability within dihydrofolate reductase-mediated gene amplified Chinese hamster ovary cells: stability in the absence of selective pressure.
Biotechnology and bioengineering 1998;60(6):679-88.
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1998: Kim E J; Kim N S; Lee G M
Development of a serum-free medium for the production of humanized antibody from Chinese hamster ovary cells using a statistical design.
In vitro cellular & developmental biology. Animal 1998;34(10):757-61.
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1998: Kim S J; Kim N S; Ryu C J; Hong H J; Lee G M
Characterization of chimeric antibody producing CHO cells in the course of dihydrofolate reductase-mediated gene amplification and their stability in the absence of selective pressure.
Biotechnology and bioengineering 1998;58(1):73-84.
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1996: Bae S W; Lee G M
Influence of fluorescent antibody probe specificity on flow cytometric analysis of antibody-producing cells.
Journal of immunological methods 1996;189(1):83-8.
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1994: Lee G M; Kim S J; Palsson B O
Enhanced specific antibody productivity of calcium alginate-entrapped hybridoma is cell line-specific.
Cytotechnology 1994;16(1):1-15.
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1994: Lee G M; Palsson B O
Monoclonal antibody production using free-suspended and entrapped hybridoma cells.
Biotechnology & genetic engineering reviews 1994;12():509-33.
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