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Hsi-Ming Lee

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Chemicals & Drugs

Disorders

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Shreyas K Roy; Suraj Sookhu; Christopher J Vieau; Yoram Vodovotz; Scott P Albert; Louis Gatto; Lorne Golub; Brian D Kubiak; Hsi-Ming Lee; Gary F Nieman
Chemically modified tetracycline 3 prevents acute respiratory distress syndrome in a porcine model of sepsis + ischemia/reperfusion-induced lung injury.
Yu Zhang; Kveta Vranková; Hsi-Ming Lee; Lorne M Golub; Ying Gu; Elena Hambardjieva; Francis Johnson
Design, synthesis and biological activity of new polyenolic inhibitors of matrix metalloproteinases: a focus on chemically-modified curcumins.
Ying Gu; Hsi-Ming Lee; Maria E Ryan; Aino Salminen; Marvin J Slepian; Timo Sorsa; Lorne M Golub
Non-antibacterial tetracyclines modulate mediators of periodontitis and atherosclerotic cardiovascular disease: a mechanistic link between local and systemic inflammation.

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All Publications

2012: Shreyas K Roy; Suraj Sookhu; Christopher J Vieau; Yoram Vodovotz; Scott P Albert; Louis Gatto; Lorne Golub; Brian D Kubiak; Hsi-Ming Lee; Gary F Nieman
Chemically modified tetracycline 3 prevents acute respiratory distress syndrome in a porcine model of sepsis + ischemia/reperfusion-induced lung injury.
Shock (Augusta, Ga.) 2012;37(4):424-32.
2012: Yu Zhang; Kveta Vranková; Hsi-Ming Lee; Lorne M Golub; Ying Gu; Elena Hambardjieva; Francis Johnson
Design, synthesis and biological activity of new polyenolic inhibitors of matrix metalloproteinases: a focus on chemically-modified curcumins.
Current medicinal chemistry 2012;19(25):4348-58.
2011: Ying Gu; Hsi-Ming Lee; Maria E Ryan; Aino Salminen; Marvin J Slepian; Timo Sorsa; Lorne M Golub
Non-antibacterial tetracyclines modulate mediators of periodontitis and atherosclerotic cardiovascular disease: a mechanistic link between local and systemic inflammation.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;64(6):573-9.
2011: Ying Gu; Hsi-Ming Lee; Sanford R Simon; Lorne M Golub
Chemically modified tetracycline-3 (CMT-3): a novel inhibitor of the serine proteinase, elastase.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;64(6):595-601.
2011: Jeffrey B Payne; Julie A Stoner; Hsi-Ming Lee; Pirkka Nummikoski; Richard A Reinhardt; L M Golub
Serum bone biomarkers and oral/systemic bone loss in humans.
Journal of dental research 2011;90(6):747-51.
2011: Jeffrey B Payne; Lorne M Golub; Julie A Stoner; Hsi-Ming Lee; Richard A Reinhardt; Timo Sorsa; Marvin J Slepian
The effect of subantimicrobial-dose-doxycycline periodontal therapy on serum biomarkers of systemic inflammation: a randomized, double-masked, placebo-controlled clinical trial.
Journal of the American Dental Association (1939) 2011;142(3):262-73.
2010: Xiaoqin Zhou; Dongfang Wang; Cherry K Ballard-Croft; Sanford R Simon; Hsi-Ming Lee; Joseph B Zwischenberger
A tetracycline analog improves acute respiratory distress syndrome survival in an ovine model.
The Annals of thoracic surgery 2010;90(2):419-26.
2010: Lorne M Golub; Hsi-Ming Lee; J A Stoner; Richard A Reinhardt; Timo Sorsa; A D Goren; Jeffrey B Payne
Doxycycline effects on serum bone biomarkers in post-menopausal women.
Journal of dental research 2010;89(6):644-9.
2010: Yu-Te Chu; Tai-Tsung Chang; Yuh-Jyh Jong; Po-Lin Kuo; Hsi-Ming Lee; Min-Sheng Lee; Hui-Wen Chang; Chih-Hsing Hung
Suppressive effects of formoterol and salmeterol on eotaxin-1 in bronchial epithelial cells.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2010;21(2 Pt 1):345-52.
2010: Ying Gu; Hsi-Ming Lee; Timo Sorsa; Sanford R Simon; Lorne M Golub
Doxycycline [corrected] inhibits mononuclear cell-mediated connective tissue breakdown.
FEMS immunology and medical microbiology 2010;58(2):218-25.
2010: Richard A Reinhardt; Julie A Stoner; Lorne M Golub; Hsi-Ming Lee; Pirkka Nummikoski; Timo Sorsa; Jeffrey B Payne
Association of gingival crevicular fluid biomarkers during periodontal maintenance with subsequent progressive periodontitis.
Journal of periodontology 2010;81(2):251-9.
2008: Lorne M Golub; Hsi-Ming Lee; Julie A Stoner; Timo Sorsa; Richard A Reinhardt; Mark S Wolff; Maria E Ryan; Pirkka V Nummikoski; Jeffrey B Payne
Subantimicrobial-dose doxycycline modulates gingival crevicular fluid biomarkers of periodontitis in postmenopausal osteopenic women.
Journal of periodontology 2008;79(8):1409-18.
2008: Ling Xu; Zhao Yu; Hsi-Ming Lee; Mark S Wolff; Lorne M Golub; Timo Sorsa; Heidi Kuula
Characteristics of collagenase-2 from gingival crevicular fluid and peri-implant sulcular fluid in periodontitis and peri-implantitis patients: pilot study.
Acta odontologica Scandinavica 2008;66(4):219-24.
2007: Rhonda D Preston; Trudy A Meinberg; Jeffrey B Payne; Marian J Schmid; Hsi-Ming Lee; Lorne M Golub; David B Marx; Richard A Reinhardt
Inflammatory mediator release following bone grafting in humans: a pilot study.
Journal of clinical periodontology 2007;34(9):797-804.
2007: Jeffrey B Payne; Julie A Stoner; Pirkka Nummikoski; Richard A Reinhardt; Arthur D Goren; Mark S Wolff; Hsi-Ming Lee; James C Lynch; Robert Valente; Lorne M Golub
Subantimicrobial dose doxycycline effects on alveolar bone loss in post-menopausal women.
Journal of clinical periodontology 2007;34(9):776-87.
2007: Clay Walker; Susan Puumala; Lorne M Golub; Julie A Stoner; Richard A Reinhardt; Hsi-Ming Lee; Jeffrey B Payne
Subantimicrobial dose doxycycline effects on osteopenic bone loss: microbiologic results.
Journal of periodontology 2007;78(8):1590-601.
2007: Jeffrey M Halter; Jay M Steinberg; Louis A Gatto; Joseph D DiRocco; Lucio A Pavone; Henry J Schiller; Scott Albert; Hsi-Ming Lee; David Carney; Gary F Nieman
Effect of positive end-expiratory pressure and tidal volume on lung injury induced by alveolar instability.
Critical care (London, England) 2007;11(1):R20.
2006: Michael F Swartz; Jeffrey M Halter; Gregory W Fink; Lucio A Pavone; Alexey Zaitsev; Hsi-Ming Lee; Jay M Steinberg; Charles J Lutz; Timo Sorsa; Louis A Gatto; Steve Landas; Christopher Hare; Gary F Nieman
Chemically modified tetracycline improves contractility in porcine coronary ischemia/reperfusion injury.
Journal of cardiac surgery 2006;21(3):254-60.
2006: Timo Sorsa; Leo Tjäderhane; Yrjö T Konttinen; Anneli Lauhio; Tuula Salo; Hsi-Ming Lee; Lorne M Golub; David L Brown; Päivi Mäntylä
Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation.
Annals of medicine 2006;38(5):306-21.
2005: Jay Steinberg; Jeffrey M Halter; Henry J Schiller; Louis A Gatto; David Carney; Hsi-Ming Lee; Lorne Golub; Gary F Nieman
Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model.
Shock (Augusta, Ga.) 2005;24(4):348-56.
2005: Richard A Reinhardt; Hsi-Ming Lee; Marian Schmid; Jeffrey B Payne; Lorne M Golub
Relationship between gelatinases and bone turnover in the healing bone defect.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2005;63(10):1455-60.
2005: Jeffrey M Halter; Jay Steinberg; Gregory Fink; Charles Lutz; Anthony Picone; Rubie Maybury; Nathan Fedors; Joseph D DiRocco; Hsi-Ming Lee; Gary F Nieman
Evidence of systemic cytokine release in patients undergoing cardiopulmonary bypass.
The Journal of extra-corporeal technology 2005;37(3):272-7.
2005: Ying Gu; Hsi-Ming Lee; Lorne M Golub; Timo Sorsa; Yrjö T Konttinen; Sanford R Simon
Inhibition of breast cancer cell extracellular matrix degradative activity by chemically modified tetracyclines.
Annals of medicine 2005;37(6):450-60.
2004: David L Brown; Kavita K Desai; Babak A Vakili; Chadi Nouneh; Hsi-Ming Lee; Lorne M Golub
Clinical and biochemical results of the metalloproteinase inhibition with subantimicrobial doses of doxycycline to prevent acute coronary syndromes (MIDAS) pilot trial.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(4):733-8.
2004: Hsi-Ming Lee; Sebastian G Ciancio; Gülay Tüter; Maria E Ryan; Eugene Komaroff; Lorne M Golub
Subantimicrobial dose doxycycline efficacy as a matrix metalloproteinase inhibitor in chronic periodontitis patients is enhanced when combined with a non-steroidal anti-inflammatory drug.
Journal of periodontology 2004;75(3):453-63.
2004: Richard A Reinhardt; Van J Sanderfer; Trudy A Meinberg; Pirkka Nummikoski; Hsi-Ming Lee; David B Marx
Local biochemical markers of bone turnover: relationship to subsequent density of healing alveolar bone defects.
Journal of clinical periodontology 2004;31(3):223-8.
2004: Jay M Steinberg; Henry J Schiller; Jeffrey M Halter; Louis A Gatto; Hsi-Ming Lee; Lucio A Pavone; Gary F Nieman
Alveolar instability causes early ventilator-induced lung injury independent of neutrophils.
American journal of respiratory and critical care medicine 2004;169(1):57-63.
2003: Jay Steinberg; Jeffrey M Halter; Henry J Schiller; Monica Dasilva; Steve Landas; Louis A Gatto; Paivi Maisi; Timo Sorsa; Minna Rajamaki; Hsi-Ming Lee; Gary F Nieman
Metalloproteinase inhibition reduces lung injury and improves survival after cecal ligation and puncture in rats.
The Journal of surgical research 2003;111(2):185-95.
2002: Yu Liu; George Tortora; Maria E Ryan; Hsi-Ming Lee; Lorne M Golub
Potato dextrose agar antifungal susceptibility testing for yeasts and molds: evaluation of phosphate effect on antifungal activity of CMT-3.
Antimicrobial agents and chemotherapy 2002;46(5):1455-61.
2002: Yu Liu; Maria E Ryan; Hsi-Ming Lee; Sanford Simon; George Tortora; Carol Lauzon; Michael K Leung; Lorne M Golub
A chemically modified tetracycline (CMT-3) is a new antifungal agent.
Antimicrobial agents and chemotherapy 2002;46(5):1447-54.
2001: Jay Steinberg; G Fink; Anthony Picone; Bruce Searles; Henry J Schiller; Hsi-Ming Lee; Gary F Nieman
Evidence of increased matrix metalloproteinase-9 concentration in patients following cardiopulmonary bypass.
The Journal of extra-corporeal technology 2001;33(4):218-22.
2001: Hsi-Ming Lee; Lorne M Golub; J Cao; Olli Teronen; Minna Laitinen; Tuula Salo; S Zucker; Timo Sorsa
CMT-3, a non-antimicrobial tetracycline (TC), inhibits MT1-MMP activity: relevance to cancer.
Current medicinal chemistry 2001;8(3):257-60.
2001: Yu Liu; Nungavaram S Ramamurthy; J Marecek; Hsi-Ming Lee; J L Chen; Maria E Ryan; Barry R Rifkin; Lorne M Golub
The lipophilicity, pharmacokinetics, and cellular uptake of different chemically-modified tetracyclines (CMTs).
Current medicinal chemistry 2001;8(3):243-52.
1999: Lorne M Golub; Nungavaram S Ramamurthy; A Llavaneras; Maria E Ryan; Hsi-Ming Lee; Yu Liu; S Bain; Timo Sorsa
A chemically modified nonantimicrobial tetracycline (CMT-8) inhibits gingival matrix metalloproteinases, periodontal breakdown, and extra-oral bone loss in ovariectomized rats.
Annals of the New York Academy of Sciences 1999;878():290-310.
1998: Lorne M Golub; Hsi-Ming Lee; Maria E Ryan; W V Giannobile; J Payne; Timo Sorsa
Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms.
Advances in dental research 1998;12(2):12-26.
1997: Lorne M Golub; Hsi-Ming Lee; Robert Greenwald; Maria E Ryan; Timo Sorsa; Tuula Salo; W V Giannobile
A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46(8):310-9.
1997: Hsi-Ming Lee; Lorne M Golub; D Chan; M Leung; K Schroeder; M Wolff; S Simon; R Crout
alpha 1-Proteinase inhibitor in gingival crevicular fluid of humans with adult periodontitis: serpinolytic inhibition by doxycycline.
Journal of periodontal research 1997;32(1 Pt 1):9-19.
1994: Lorne M Golub; M Wolff; S Roberts; Hsi-Ming Lee; M Leung; G S Payonk
Treating periodontal diseases by blocking tissue-destructive enzymes.
Journal of the American Dental Association (1939) 1994;125(2):163-9; discussion 169-71.
1993: Nungavaram S Ramamurthy; Anthony T Vernillo; Robert Greenwald; Hsi-Ming Lee; Timo Sorsa; Lorne M Golub; Barry R Rifkin
Reactive oxygen species activate and tetracyclines inhibit rat osteoblast collagenase.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8(10):1247-53.