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Jeewoo Lee

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Cheol Ho Heo; Hyung Joong Kim; Sung Hoon Baik; Kyung Ho Kim; Yong Soo Kim; Jeewoo Lee; Inhee Mook-Jung; Hyundong Song; Hwan Myung Kim
A two-photon fluorescent probe for amyloid-β plaques in living mice.
Young Taek Han; Hyun-Seok Hong; Hee Kim; Nam-Jung Kim; Young-Ho Kim; Jeewoo Lee; Sujin Lee; Hyun-Ju Park; Dohyun Son; Dong Jo Chang; Gyeong-In Choi; Hee-Jin Ha; Hwayoung Yun; Young-Ger Suh
Ligand-based design, synthesis, and biological evaluation of 2-aminopyrimidines, a novel series of receptor for advanced glycation end products (RAGE) inhibitors.
Myeong Seop Kim; Mi-Yeon Kim; Yong Soo Kim; Babette Y Kögel; Eun Joo Kwak; Gregor Bahrenberg; Rahul S Bhondwe; Peter M Blumberg; Seong-Hee Cho; Sun Choi; Thomas Christoph; Ian A DeAndrea-Lazarus; Robert Frank; Dong Wook Kang; Ho Shin Kim; Seul-gi Park; Young Soo Park; Larry V Pearce; Hyungchul Ryu; Klaus Schiene; Sejin Seo; Karam Son; Hannelore Stockhausen; Jeewoo Lee
2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent transient receptor potential vanilloid 1 (TRPV1) antagonists: structure-activity relationships of 2-amino derivatives in the N-(6-trifluoromethylpyridin-3-ylmethyl) C-region.

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All Publications

2013: Cheol Ho Heo; Hyung Joong Kim; Sung Hoon Baik; Kyung Ho Kim; Yong Soo Kim; Jeewoo Lee; Inhee Mook-Jung; Hyundong Song; Hwan Myung Kim
A two-photon fluorescent probe for amyloid-β plaques in living mice.
Chemical communications (Cambridge, England) 2013;49(13):1303-5.
2012: Young Taek Han; Hyun-Seok Hong; Hee Kim; Nam-Jung Kim; Young-Ho Kim; Jeewoo Lee; Sujin Lee; Hyun-Ju Park; Dohyun Son; Dong Jo Chang; Gyeong-In Choi; Hee-Jin Ha; Hwayoung Yun; Young-Ger Suh
Ligand-based design, synthesis, and biological evaluation of 2-aminopyrimidines, a novel series of receptor for advanced glycation end products (RAGE) inhibitors.
Journal of medicinal chemistry 2012;55(21):9120-35.
2012: Myeong Seop Kim; Mi-Yeon Kim; Yong Soo Kim; Babette Y Kögel; Eun Joo Kwak; Gregor Bahrenberg; Rahul S Bhondwe; Peter M Blumberg; Seong-Hee Cho; Sun Choi; Thomas Christoph; Ian A DeAndrea-Lazarus; Robert Frank; Dong Wook Kang; Ho Shin Kim; Seul-gi Park; Young Soo Park; Larry V Pearce; Hyungchul Ryu; Klaus Schiene; Sejin Seo; Karam Son; Hannelore Stockhausen; Jeewoo Lee
2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent transient receptor potential vanilloid 1 (TRPV1) antagonists: structure-activity relationships of 2-amino derivatives in the N-(6-trifluoromethylpyridin-3-ylmethyl) C-region.
Journal of medicinal chemistry 2012;55(19):8392-408.
2012: Yongsung Cho; Ho Shin Kim; Myeong Seop Kim; Jiyoun Lee; Matthew A Morgan; Vladimir A Pavlyukovets; Larry V Pearce; Jihyae Ann; Peter M Blumberg; Jeewoo Lee
The SAR analysis of TRPV1 agonists with the α-methylated B-region.
Bioorganic & medicinal chemistry letters 2012;22(16):5227-31.
2012: Rahul S Bhondwe; Peter M Blumberg; Sun Choi; Dong Wook Kang; Ho Shin Kim; Myeong Seop Kim; Seul-gi Park; Vladimir A Pavlyukovets; Larry V Pearce; Karam Son; Krystle A Lang Kuhs; Jeewoo Lee
Structure-activity relationships and molecular modeling of the N-(3-pivaloyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl] thiourea template for TRPV1 antagonism.
Bioorganic & medicinal chemistry letters 2012;22(11):3656-60.
2012: Cassandra E Deering-Rice; Mark E Johansen; Jeewoo Lee; Jessica K Roberts; Erin G Romero; Karen C Thomas; John M Veranth; Garold S Yost; Christopher A Reilly
Transient receptor potential vanilloid-1 (TRPV1) is a mediator of lung toxicity for coal fly ash particulate material.
Molecular pharmacology 2012;81(3):411-9.
2012: Wei Sun; Shivaji A Thorat; Attila Toth; Richard Tran; Keliang Liu; Matthew A Morgan; Vladimir A Pavlyukovets; Larry V Pearce; Christopher B Ryder; Hyungchul Ryu; Rahul S Bhondwe; Peter M Blumberg; Yongsung Cho; Dong Wook Kang; Ho Shin Kim; Myeong Seop Kim; Yong Soo Kim; Jozsef Lazar; Jeewoo Lee
2-(4-Methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the B and C-regions.
Bioorganic & medicinal chemistry 2012;20(3):1310-8.
2012: Minho Moon; Dong Woo Nam; Hyundong Song; Sung Hoon Baik; Hyun-Seok Hong; Yong Soo Kim; Sun-Young Kook; Jeewoo Lee; Inhee Mook-Jung
Intracellular amyloid-β accumulation in calcium-binding protein-deficient neurons leads to amyloid-β plaque formation in animal model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2012;29(3):615-28.
2011: Kyeong-Ryoon Lee; Han-Joo Maeng; Chang-Koo Shim; Yoon-Jee Chae; Saeho Chong; Dae-Duk Kim; Jeewoo Lee; Suk-Jae Chung
Physiologically based pharmacokinetic modeling of SNU-0039, an anti-Alzheimer's agent, in rats.
Journal of pharmacokinetics and pharmacodynamics 2011;38(5):637-51.
2011: Karen C Thomas; Manivannan Ethirajan; Kiumars Shahrokh; Hao Sun; Jeewoo Lee; Thomas E Cheatham; Garold S Yost; Christopher A Reilly
Structure-activity relationship of capsaicin analogs and transient receptor potential vanilloid 1-mediated human lung epithelial cell toxicity.
The Journal of pharmacology and experimental therapeutics 2011;337(2):400-10.
2011: Jin Hee Lee; Yoonji Lee; Hyungchul Ryu; Dong Wook Kang; Jeewoo Lee; Jozsef Lazar; Larry V Pearce; Vladimir A Pavlyukovets; Peter M Blumberg; Sun Choi
Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies.
Journal of computer-aided molecular design 2011;25(4):317-27.
2011: Peter M Blumberg; Larry V Pearce; Jeewoo Lee
TRPV1 activation is not an all-or-none event: TRPV1 partial agonism/antagonism and its regulatory modulation.
Current topics in medicinal chemistry 2011;11(17):2151-8.
2011: Kwang Su Lim; Dong Wook Kang; Yong Soo Kim; Myeong Seop Kim; Seul-Gi Park; Sun Choi; Larry V Pearce; Peter M Blumberg; Jeewoo Lee
Receptor activity and conformational analysis of 5'-halogenated resiniferatoxin analogs as TRPV1 ligands.
Bioorganic & medicinal chemistry letters 2011;21(1):299-302.
2010: Dong Wook Kang; Yong Soo Kim; Kwang Su Lim; Myeong Seop Kim; Larry V Pearce; Vladimir A Pavlyukovets; Andy K Tao; Krystle A Lang-Kuhs; Peter M Blumberg; Jeewoo Lee
Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin.
Bioorganic & medicinal chemistry 2010;18(22):8092-105.
2010: Ji-Hye Kang; Yerim Kim; Shin-Hye Won; Song-Kyu Park; Chang Woo Lee; Hwan Mook Kim; Nancy E Lewin; Nicholas A Perry; Larry V Pearce; Daniel J Lundberg; Robert J Surawski; Peter M Blumberg; Jeewoo Lee
Polar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agents.
Bioorganic & medicinal chemistry letters 2010;20(3):1008-12.
2009: Hyun-Kyung Choi; Sun Choi; Yoonji Lee; Dong Wook Kang; Hyungchul Ryu; Han-Joo Maeng; Suk-Jae Chung; Vladimir A Pavlyukovets; Larry V Pearce; Attila Toth; Richard Tran; Yun Wang; Matthew A Morgan; Peter M Blumberg; Jeewoo Lee
Non-vanillyl resiniferatoxin analogues as potent and metabolically stable transient receptor potential vanilloid 1 agonists.
Bioorganic & medicinal chemistry 2009;17(2):690-8.
2009: Ju-Ok Lim; Mi-Kyoung Jin; Hyungchul Ryu; Dong Wook Kang; Jeewoo Lee; Larry V Pearce; Richard Tran; Attila Toth; Peter M Blumberg
Conformationally constrained analogues of N'-(4-tert-butylbenzyl)-N-(4-methylsulfonylaminobenzyl)thiourea as TRPV1 antagonists.
European journal of medicinal chemistry 2009;44(1):322-31.
2009: Taehee Kang; Eun-Jung Yoon; Eun-Chil Choi; Sunghoon Kim; Jeewoo Lee
2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors.
European journal of medicinal chemistry 2009;44(1):239-50.
2008: Dehui Duan; Dina M Sigano; James A Kelley; Christopher C Lai; Nancy E Lewin; Noemi Kedei; Megan L Peach; Jeewoo Lee; Thushara P Abeyweera; Susan A Rotenberg; Hee Kim; Young Ho Kim; Saïd El Kazzouli; Jae-Uk Chung; Howard A Young; Matthew R Young; Alyson Baker; Nancy H Colburn; Adriana Haimovitz-Friedman; Jean-Philip Truman; Damon Parrish; Jeffrey Deschamps; Nicholas A Perry; Robert J Surawski; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities.
Journal of medicinal chemistry 2008;51(17):5198-220.
2008: Alan R Light; Ronald W Hughen; Jie Zhang; Jon Rainier; Zhuqing Liu; Jeewoo Lee
Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1.
Journal of neurophysiology 2008;100(3):1184-201.
2008: Jeewoo Lee; Y H Sung; C Cheong; Yong Soo Choi; H K Jeon; W Sun; W C Hahn; F Ishikawa; Hyang Woo Lee
TERT promotes cellular and organismal survival independently of telomerase activity.
Oncogene 2008;27(26):3754-60.
2008: Larry V Pearce; Attila Toth; HyungChul Ryu; Dong Wook Kang; Hyun-Kyung Choi; Mi-Kyung Jin; Jeewoo Lee; Peter M Blumberg
Differential modulation of agonist and antagonist structure activity relations for rat TRPV1 by cyclosporin A and other protein phosphatase inhibitors.
Naunyn-Schmiedeberg's archives of pharmacology 2008;377(2):149-57.
2008: Hyungchul Ryu; Mi-Kyung Jin; Su Yeon Kim; Hyun-Kyung Choi; Sang-Uk Kang; Dong Wook Kang; Jeewoo Lee; Larry V Pearce; Vladimir A Pavlyukovets; Matthew A Morgan; Richard Tran; Attila Toth; Daniel J Lundberg; Peter M Blumberg
Stereospecific high-affinity TRPV1 antagonists: chiral N-(2-benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues.
Journal of medicinal chemistry 2008;51(1):57-67.
2007: Jae-Uk Chung; Su Yeon Kim; Ju-Ok Lim; Hyun-Kyung Choi; Sang-Uk Kang; Hae-Seok Yoon; Hyungchul Ryu; Dong Wook Kang; Jeewoo Lee; Bomi Kang; Sun Choi; Attila Toth; Larry V Pearce; Vladimir A Pavlyukovets; Daniel J Lundberg; Peter M Blumberg
Alpha-substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists.
Bioorganic & medicinal chemistry 2007;15(18):6043-53.
2007: Dong Wook Kang; Hyungchul Ryu; Jeewoo Lee; Krystle A Lang; Vladimir A Pavlyukovets; Larry V Pearce; Tetsurou Ikeda; Jozsef Lazar; Peter M Blumberg
Halogenation of 4-hydroxy-3-methoxybenzyl thiourea TRPV1 agonists showed enhanced antagonism to capsaicin.
Bioorganic & medicinal chemistry letters 2007;17(1):214-9.
2006: Su Yeon Kim; Eun-Jeong Yoon; Eung-Chil Choi; Sunghoon Kim; Taehee Kang; Farhana Samrin; Sadhna Puri; Jeewoo Lee
Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors.
Bioorganic & medicinal chemistry 2006;14(21):7154-9.
2006: Su Yeon Kim; Yeon-Sook Lee; Taehee Kang; Sunghoon Kim; Jeewoo Lee
Pharmacophore-based virtual screening: the discovery of novel methionyl-tRNA synthetase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(18):4898-907.
2006: Jozsef Lazar; Derek C Braun; Attila Tóth; Yun Wang; Larry V Pearce; Vladimir A Pavlyukovets; Peter M Blumberg; Susan H Garfield; Stephen Wincovitch; Hyun-Kyung Choi; Jeewoo Lee
Kinetics of penetration influence the apparent potency of vanilloids on TRPV1.
Molecular pharmacology 2006;69(4):1166-73.
2006: Jeewoo Lee; Ji-Hye Kang; Kee-Chung Han; Yerim Kim; Su Yeon Kim; Hae-Suk Youn; Inhee Mook-Jung; Hee Kim; Jee Hye Lo Han; Hee-Jin Ha; Young Ho Kim; Victor E Marquez; Nancy E Lewin; Larry V Pearce; Daniel J Lundberg; Peter M Blumberg
Branched diacylglycerol-lactones as potent protein kinase C ligands and alpha-secretase activators.
Journal of medicinal chemistry 2006;49(6):2028-36.
2006: Jeewoo Lee; Ju-Hyun Lee; Su Yeon Kim; Nicholas A Perry; Nancy E Lewin; Jolene A Ayres; Peter M Blumberg
2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands.
Bioorganic & medicinal chemistry 2006;14(6):2022-31.
2005: Jeewoo Lee; Sang-Uk Kang; Min-Jung Kil; Myoungyoup Shin; Ju-Ok Lim; Hyun-Kyung Choi; Mi-Kyung Jin; Su Yeon Kim; Sung-Eun Kim; Yong-Sil Lee; Kyung-Hoon Min; Young-Ho Kim; Hee-Jin Ha; Richard Tran; Jacqueline D Welter; Yun Wang; Tamas Szabo; Larry V Pearce; Daniel J Lundberg; Attila Toth; Vladimir A Pavlyukovets; Matthew A Morgan; Peter M Blumberg
Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists.
Bioorganic & medicinal chemistry letters 2005;15(18):4136-42.
2005: Jeewoo Lee; Mi-Kyung Jin; Sang-Uk Kang; Su Yeon Kim; Jiyoun Lee; Myoungyoup Shin; Jaemin Hwang; Sookhyun Cho; Yeon-Sil Choi; Hyun-Kyung Choi; Sung-Eun Kim; Young-Ger Suh; Yong-Sil Lee; Young-Ho Kim; Hee-Jin Ha; Attila Toth; Larry V Pearce; Richard Tran; Tamas Szabo; Jacqueline D Welter; Daniel J Lundberg; Yun Wang; Jozsef Lazar; Vladimir A Pavlyukovets; Matthew A Morgan; Peter M Blumberg
Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists.
Bioorganic & medicinal chemistry letters 2005;15(18):4143-50.
2005: Young-Ger Suh; Yong-Sil Lee; Kyung-Hoon Min; Ok-Hui Park; Jin-Kwan Kim; Ho-Sun Seung; Seung-Yong Seo; Bo-Young Lee; Yeon-Hee Nam; Kwang-Ok Lee; Hee-Doo Kim; Hyeung-geun Park; Jeewoo Lee; Uhtaek Oh; Ju-Ok Lim; Sang-Uk Kang; Min-Jung Kil; Jae-Yeon Koo; Song Seok Shin; Yung Hyup Joo; Jin Kwan Kim; Yeon Su Jeong; Sun-Young Kim; Young-Ho Park
Novel potent antagonists of transient receptor potential channel, vanilloid subfamily member 1: structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents.
Journal of medicinal chemistry 2005;48(18):5823-36.
2005: Sung Eun Kim; Su Yeon Kim; Sunghoon Kim; Taehee Kang; Jeewoo Lee
Deoxyribosyl analogues of methionyl and isoleucyl sulfamate adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.
Bioorganic & medicinal chemistry letters 2005;15(14):3389-93.
2005: Attila Tóth; Yun Wang; Noemi Kedei; Richard Tran; Larry V Pearce; Sang-Uk Kang; Mi-Kyung Jin; Hyun-Kyung Choi; Jeewoo Lee; Peter M Blumberg
Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1.
Life sciences 2005;76(25):2921-32.
2005: Christopher A Reilly; Mark E Johansen; Diane L Lanza; Jeewoo Lee; Ju-Ok Lim; Garold S Yost
Calcium-dependent and independent mechanisms of capsaicin receptor (TRPV1)-mediated cytokine production and cell death in human bronchial epithelial cells.
Journal of biochemical and molecular toxicology 2005;19(4):266-75.
2004: Seung-Jun Oh; Kyo Chul Lee; Sang-Yoon Lee; Eun Kyoung Ryu; Hideo Saji; Yearn Seong Choe; Dae Yoon Chi; Sang Eun Kim; Jeewoo Lee; Byung-Tae Kim
Synthesis and evaluation of fluorine-substituted 1H-pyrrolo[2,3-b]pyridine derivatives for dopamine D4 receptor imaging.
Bioorganic & medicinal chemistry 2004;12(21):5505-13.
2004: Ji-Hye Kang; Su Yeon Kim; Jeewoo Lee; Victor E Marquez; Nancy E Lewin; Larry V Pearce; Peter M Blumberg
Macrocyclic diacylglycerol-bis-lactones as conformationally constrained analogues of diacylglycerol-lactones. Interactions with protein kinase C.
Journal of medicinal chemistry 2004;47(16):4000-7.
2004: Ji-Hye Kang; Maqbool A Siddiqui; Dina M Sigano; Krzysztof Krajewski; Nancy E Lewin; Yongmei Pu; Peter M Blumberg; Jeewoo Lee; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 24. Asymmetric synthesis of a chiral (R)-DAG-lactone template as a versatile precursor for highly functionalized DAG-lactones.
Organic letters 2004;6(14):2413-6.
2004: Jeewoo Lee; Su Yeon Kim; Jiyoun Lee; Myungshim Kang; Min-Jung Kil; Hyun-Kyung Choi; Mi-Kyung Jin; Yun Wang; Attila Toth; Larry V Pearce; Daniel J Lundberg; Richard Tran; Peter M Blumberg
Analysis of structure-activity relationships with the N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea template for vanilloid receptor 1 antagonism.
Bioorganic & medicinal chemistry 2004;12(13):3411-20.
2004: Su Yeon Kim; Jeewoo Lee
3D-QSAR analysis of conformationally constrained diacylglycerol (DAG) analogues as potent protein kinase C (PK-C) ligands.
Bioorganic & medicinal chemistry 2004;12(10):2639-44.
2004: Jeewoo Lee; Sang-Uk Kang; Hyun-Kyung Choi; Jiyoun Lee; Ju-Ok Lim; Min-Jung Kil; Mi-Kyung Jin; Kang-Pil Kim; Jong-Hyuk Sung; Suk-Jae Chung; Hee-Jin Ha; Young-Ho Kim; Larry V Pearce; Richard Tran; Daniel J Lundberg; Yun Wang; Attila Toth; Peter M Blumberg
Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity.
Bioorganic & medicinal chemistry letters 2004;14(9):2291-7.
2004: Chong Hyun Ryu; Mi Jung Jang; Jeong Wha Jung; Ju-Hyun Park; Hye Young Choi; Young-Ger Suh; Uhtaek Oh; Hyeung-geun Park; Jeewoo Lee; Hyun-Ju Koh; Joo-Hyun Mo; Yung Hyup Joo; Young-Ho Park; Hee-Doo Kim
Chain-branched 1,3-dibenzylthioureas as vanilloid receptor 1 antagonists.
Bioorganic & medicinal chemistry letters 2004;14(7):1751-5.
2004: Sang-Yoon Lee; Yearn Seong Choe; Kyung-Han Lee; Jeewoo Lee; Yong Choi; Byung-Tae Kim
Synthesis of 7'-[123I]iodo-D-luciferin for in vivo studies of firefly luciferase gene expression.
Bioorganic & medicinal chemistry letters 2004;14(5):1161-3.
2004: Jeewoo Lee; Su Yeon Kim; Soyoung Park; Ju-Ok Lim; Ji-Min Kim; Myungshim Kang; Jiyoun Lee; Sang-Uk Kang; Hyun-Kyung Choi; Mi-Kyung Jin; Jacqueline D Welter; Tamas Szabo; Richard Tran; Larry V Pearce; Attila Toth; Peter M Blumberg
Structure-activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding.
Bioorganic & medicinal chemistry 2004;12(5):1055-69.
2004: Hyeung-geun Park; Ji-yeon Choi; Sea-Hoon Choi; Mi-kyung Park; Jihye Lee; Young-Ger Suh; Hawon Cho; Uhtaek Oh; Jiyoun Lee; Sang-Uk Kang; Jeewoo Lee; Hee-Doo Kim; Young-Ho Park; Yeon Su Jeong; Jin Kyu Choi; Sang-sup Jew
N-4-Substituted-benzyl-N'-tert-butylbenzyl thioureas as vanilloid receptor ligands: investigation on the role of methanesulfonamido group in antagonistic activity.
Bioorganic & medicinal chemistry letters 2004;14(3):787-91.
2004: Jeewoo Lee; Sang-Uk Kang; Ju-Ok Lim; Hyun-Kyung Choi; Mi-Kyung Jin; Attila Toth; Larry V Pearce; Richard Tran; Yun Wang; Tamas Szabo; Peter M Blumberg
N-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: analysis of structure-activity relationships for the "C-Region".
Bioorganic & medicinal chemistry 2004;12(2):371-85.
2004: Jeewoo Lee; Su Yeon Kim; Ji-Hye Kang; Geza Acs; Peter Acs; Peter M Blumberg; Victor E Marquez
Conformationally constrained diacylglycerol (DAG) analogs: 4-C-hydroxyethyl-5-O-acyl-2,3-dideoxy-D-glyceropentono-1,4-lactone analogs as protein kinase C (PKC) ligands.
European journal of medicinal chemistry 2004;39(1):69-77.
2003: Young-Ger Suh; Yong-Sil Lee; Kyung-Hoon Min; Ok-Hui Park; Ho-Sun Seung; Hee-Doo Kim; Hyeung-geun Park; J- Yeon Choi; Jeewoo Lee; Sang-Wook Kang; Uhtaek Oh; Jae-yeon Koo; Yung Hyup Joo; Sun-Young Kim; Jin Kwan Kim; Young Ho Park
Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects.
Bioorganic & medicinal chemistry letters 2003;13(24):4389-93.
2003: Su Yeon Kim; Jeewoo Lee
3-D-QSAR study and molecular docking of methionyl-tRNA synthetase inhibitors.
Bioorganic & medicinal chemistry 2003;11(24):5325-31.
2003: In-Ho Park; Eun Mi Hwang; Hyun Seok Hong; Jung Hyun Boo; Sang Soo Oh; Jeewoo Lee; Min Whan Jung; Oh Young Bang; Seung Kim; Inhee Mook-Jung
Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice.
Neurobiology of aging 2003;24(5):637-43.
2003: Yun Wang; Attila Toth; Richard Tran; Tamas Szabo; Jacqueline D Welter; Peter M Blumberg; Jiyoun Lee; Sang-Uk Kang; Ju-Ok Lim; Jeewoo Lee
High-affinity partial agonists of the vanilloid receptor.
Molecular pharmacology 2003;64(2):325-33.
2003: Jeewoo Lee; Jiyoun Lee; Myungshim Kang; Myoungyoup Shin; Ji-Min Kim; Sang-Uk Kang; Ju-Ok Lim; Hyun-Kyung Choi; Young-Ger Suh; Hyeung-geun Park; Uhtaek Oh; Hee-Doo Kim; Young-Ho Park; Hee-Jin Ha; Young-Ho Kim; Attila Toth; Yun Wang; Richard Tran; Larry V Pearce; Daniel J Lundberg; Peter M Blumberg
N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor.
Journal of medicinal chemistry 2003;46(14):3116-26.
2003: Yongseok Choi; Ji-Hye Kang; Nancy E Lewin; Peter M Blumberg; Jeewoo Lee; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain.
Journal of medicinal chemistry 2003;46(13):2790-3.
2003: Ji-Hye Kang; Hye-Eun Chung; Su Yeon Kim; Yerim Kim; Jeewoo Lee; Nancy E Lewin; Larry V Pearce; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol (DAG). Effect on protein kinase C (PK-C) binding by the isosteric replacement of sn-1 and sn-2 esters in DAG-lactones.
Bioorganic & medicinal chemistry 2003;11(12):2529-39.
2003: Jeewoo Lee; Sung Eun Kim; Ji Young Lee; Su Yeon Kim; Sang Uk Kang; Seung Hwan Seo; Moon Woo Chun; Taehee Kang; Soo Young Choi; Hea Ok Kim
N-Alkoxysulfamide, N-hydroxysulfamide, and sulfamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.
Bioorganic & medicinal chemistry letters 2003;13(6):1087-92.
2003: Hyeung-geun Park; Mi-kyung Park; Ji-yeon Choi; Sea-Hoon Choi; Jihye Lee; Boon-saeng Park; Myoung Goo Kim; Young-Ger Suh; Hawon Cho; Uhtaek Oh; Jeewoo Lee; Hee-Doo Kim; Young-Ho Park; Hyun-Ju Koh; Kyung Min Lim; Joo Hyun Moh; Sang-sup Jew
Synthesis of N,N',N"-trisubstituted thiourea derivatives and their antagonist effect on the vanilloid receptor.
Bioorganic & medicinal chemistry letters 2003;13(4):601-4.
2003: Hyeung geun Park; Mi kyung Park; Ji yeon Choi; Sea hoon Choi; Jeewoo Lee; Young ger Suh; Uhtaek Oh; Jihye Lee; Hee-Doo Kim; Young Ho Park; Yeon Su Jeong; Jin Kyu Choi; Sang-sup Jew
Synthesis of 2-substituted-pyrrolidinethiourea derivatives and their antagonist effect on vanilloid receptor.
Bioorganic & medicinal chemistry letters 2003;13(2):197-200.
2002: Yun Wang; Tamas Szabo; Jacqueline D Welter; Attila Toth; Richard Tran; Jiyoun Lee; Sang-Uk Kang; Young-Ger Suh; Peter M Blumberg; Jeewoo Lee
High affinity antagonists of the vanilloid receptor.
Molecular pharmacology 2002;62(4):947-56.
2002: Jeewoo Lee; Jiyoun Lee; Myung-Sim Kang; Kang-Pil Kim; Suk-Jae Chung; Peter M Blumberg; Jung-Bum Yi; Young Ho Park
Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics.
Bioorganic & medicinal chemistry 2002;10(4):1171-9.
2002: Maria Laura Garcia-Bermejo; Federico Coluccio Leskow; Teruhiko Fujii; Qiming Wang; Peter M Blumberg; Motoi Ohba; Toshio Kuroki; Kee-Chung Han; Jeewoo Lee; Victor E Marquez; Marcelo G Kazanietz
Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha.
The Journal of biological chemistry 2002;277(1):645-55.
2002: Kyung-Soo Chun; Kwan-Kyu Park; Jeewoo Lee; Myungshin Kang; Young-Joon Surh
Inhibition of mouse skin tumor promotion by anti-inflammatory diarylheptanoids derived from Alpinia oxyphylla Miquel (Zingiberaceae).
Oncology research 2002;13(1):37-45.
2001: Jeewoo Lee; Kee-Chung Han; Ji-Hye Kang; L L Pearce; Nancy E Lewin; S Yan; Samira Benzaria; Marc C Nicklaus; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications for isozyme specificity.
Journal of medicinal chemistry 2001;44(25):4309-12.
2001: Jeewoo Lee; J Lee; Tamas Szabo; A F Gonzalez; Jacqueline D Welter; Peter M Blumberg
N-(3-acyloxy-2-benzylpropyl)-N'-dihydroxytetrahydrobenzazepine and tetrahydroisoquinoline thiourea analogues as vanilloid receptor ligands.
Bioorganic & medicinal chemistry 2001;9(7):1713-20.
2001: Jeewoo Lee; Sang Uk Kang; Su Yeon Kim; Sung Eun Kim; Y J Job; Sanghee Kim
Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.
Bioorganic & medicinal chemistry letters 2001;11(8):965-8.
2001: Jeewoo Lee; Sang Uk Kang; Su Yeon Kim; Sung Eun Kim; MK Kang; YJ Jo; Sanghee Kim
Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.
Bioorganic & medicinal chemistry letters 2001;11(8):961-4.
2001: Jeewoo Lee; Kee-Chung Han; S Y Lee; Su Yeon Kim; Ji-Hye Kang; Nancy E Lewin; L S Best; Peter M Blumberg; Victor E Marquez
5-acyloxy-5-hydroxymethyltetrahydro-2-furancarboxylate as a novel template for protein kinase C (PKC) binding.
Farmaco (Società chimica italiana : 1989) 2001;56(3):203-10.
2001: Jeewoo Lee; J Lee; Jeongmin Kim; Su Yeon Kim; Moon Woo Chun; H Cho; S W Hwang; U Oh; Y H Park; Victor E Marquez; M Beheshti; Tamas Szabo; Peter M Blumberg
N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics.
Bioorganic & medicinal chemistry 2001;9(1):19-32.
2000: Kassoum Nacro; B Bienfait; Jeewoo Lee; Kee-Chung Han; Ji-Hye Kang; Samira Benzaria; Nancy E Lewin; Dipak Bhattacharyya; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?
Journal of medicinal chemistry 2000;43(5):921-44.
1999: Jeewoo Lee; S U Park; J Y Kim; J K Kim; J Lee; U Oh; Victor E Marquez; M Beheshti; Q J Wang; S Modarres; Peter M Blumberg
3-Acyloxy-2-phenalkylpropyl amides and esters of homovanillic acid as novel vanilloid receptor agonists.
Bioorganic & medicinal chemistry letters 1999;9(20):2909-14.
1999: Jeewoo Lee; Ji-Hye Kang; S Y Lee; Kee-Chung Han; C M Torres; Dipak Bhattacharyya; Peter M Blumberg; Victor E Marquez
Protein kinase C ligands based on tetrahydrofuran templates containing a new set of phorbol ester pharmacophores.
Journal of medicinal chemistry 1999;42(20):4129-39.
1999: Jeewoo Lee; Sang Uk Kang; MK Kang; Moon Woo Chun; YJ Jo; J H Kwak; Sanghee Kim
Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase.
Bioorganic & medicinal chemistry letters 1999;9(10):1365-70.
1999: Victor E Marquez; Kassoum Nacro; Samira Benzaria; Jeewoo Lee; R Sharma; K Teng; GW Milne; B Bienfait; Shulin Wang; Nancy E Lewin; Peter M Blumberg
The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands.
Pharmacology & therapeutics 1999;82(2-3):251-61.
1999: J S Jang; Su-Jun Lee; Young Hun Choi; P M Nguyen; Jeewoo Lee; Sang-Gu Hwang; ML Wu; E Takano; M Maki; Pierre A Henkart; Jane Trepel
Posttranslational regulation of the retinoblastoma gene family member p107 by calpain protease.
Oncogene 1999;18(10):1789-96.
1998: Jeewoo Lee; MK Kang; Moon Woo Chun; YJ Jo; J H Kwak; Sanghee Kim
Methionine analogues as inhibitors of methionyl-tRNA synthetase.
Bioorganic & medicinal chemistry letters 1998;8(24):3511-4.
1998: Jeewoo Lee
Design and synthesis of bioisosteres of ultrapotent protein kinase C (PKC) ligand, 5-acetoxymethyl-5-hydroxymethyl-3-alkylidene tetrahydro-2-furanone.
Archives of pharmacal research 1998;21(4):452-7.
1998: Moon Woo Chun; K K Olmstead; Y Choi; C O Lee; C K Lee; J H Kim; Jeewoo Lee
Synthesis and biological activity of 5-hydroxy-4-quinolones and 5-methoxy-4-quinolones as truncated acridones.
Archives of pharmacal research 1998;21(4):445-51.
1998: Victor E Marquez; R Sharma; Shulin Wang; Nancy E Lewin; Peter M Blumberg; I S Kim; Jeewoo Lee
Conformationally constrained analogues of diacylglycerol (DAG). 14. Dissection of the roles of the sn-1 and sn-2 carbonyls in DAG mimetics by isopharmacophore replacement.
Bioorganic & medicinal chemistry letters 1998;8(13):1757-62.
1998: Su-Jun Lee; M J Ha; Jeewoo Lee; Phuongmai Nguyen; Young Hun Choi; F Pirnia; W K Kang; X F Wang; Seong-Jin Kim; Jane Trepel
Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells.
The Journal of biological chemistry 1998;273(17):10618-23.
1998: Jeewoo Lee; N E Lewin; P M Blumberg; V E Marquez
Conformationally constrained analogues of diacylglycerol having a perhydrofuro[3,4-c]furan-1,4-dione bis-gamma-butyrolactone skeleton.
Archives of pharmacal research 1998;21(2):164-7.
1997: Young Hun Choi; Su-Jun Lee; Phuongmai Nguyen; J S Jang; Jeewoo Lee; ML Wu; E Takano; M Maki; Pierre A Henkart; Jane Trepel
Regulation of cyclin D1 by calpain protease.
The Journal of biological chemistry 1997;272(45):28479-84.