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Pier Giovanni Baraldi

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Chemicals & Drugs

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Drug Screening Assays, Antitumor

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Romeo Romagnoli; Mojgan Aghazadeh Tabrizi; Pier Giovanni Baraldi; Marcella Bassetto; Giuseppe Basso; Roberta Bortolozzi; Andrea Brancale; Ignazio Castagliuolo; Ernest Hamel; Maria Kimatrai Salvador; Delia Preti; Giampietro Viola
Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents.
Mojgan Aghazadeh Tabrizi; Pier Giovanni Baraldi; Stefania Baraldi; Pier Andrea Borea; Carmen Corciulo; Allan R Moorman; Delia Preti; Romeo Romagnoli; Giulia Saponaro; Fabrizio Vincenzi; Katia Varani
Design, synthesis, and pharmacological properties of new heteroarylpyridine/heteroarylpyrimidine derivatives as CB(2) cannabinoid receptor partial agonists.
Romeo Romagnoli; Maria Kimatrai Salvador; Mojgan Aghazadeh Tabrizi; Pier Giovanni Baraldi; Marcella Bassetto; Giuseppe Basso; Roberta Bortolozzi; Andrea Brancale; M Encarnacion Camacho; Ernest Hamel; Delia Preti; Giampietro Viola
Synthesis and biological evaluation of 2-substituted-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents.

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All Publications

2013: Romeo Romagnoli; Mojgan Aghazadeh Tabrizi; Pier Giovanni Baraldi; Marcella Bassetto; Giuseppe Basso; Roberta Bortolozzi; Andrea Brancale; Ignazio Castagliuolo; Ernest Hamel; Maria Kimatrai Salvador; Delia Preti; Giampietro Viola
Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents.
Journal of medicinal chemistry 2013;56(6):2606-18.
2013: Mojgan Aghazadeh Tabrizi; Pier Giovanni Baraldi; Stefania Baraldi; Pier Andrea Borea; Carmen Corciulo; Allan R Moorman; Delia Preti; Romeo Romagnoli; Giulia Saponaro; Fabrizio Vincenzi; Katia Varani
Design, synthesis, and pharmacological properties of new heteroarylpyridine/heteroarylpyrimidine derivatives as CB(2) cannabinoid receptor partial agonists.
Journal of medicinal chemistry 2013;56(3):1098-112.
2012: Romeo Romagnoli; Maria Kimatrai Salvador; Mojgan Aghazadeh Tabrizi; Pier Giovanni Baraldi; Marcella Bassetto; Giuseppe Basso; Roberta Bortolozzi; Andrea Brancale; M Encarnacion Camacho; Ernest Hamel; Delia Preti; Giampietro Viola
Synthesis and biological evaluation of 2-substituted-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents.
Bioorganic & medicinal chemistry 2012;20(24):7083-94.
2012: Romeo Romagnoli; Maria Kimatrai Salvador; Mojgan Aghazadeh Tabrizi; Pier Giovanni Baraldi; Pier Andrea Borea; LUISA-CARLOTA LÓPEZ-CARA; Maria Dora Carrion; Olga Cruz-Lopez; Allan R Moorman; Delia Preti; Fabrizio Vincenzi; Katia Varani
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor.
Journal of medicinal chemistry 2012;55(17):7719-35.
2012: Pier Giovanni Baraldi; Stefania Baraldi; Pier Andrea Borea; Allan R Moorman; Delia Preti; Romeo Romagnoli; Emanuela Ruggiero; Giulia Saponaro; Martina Targa; Katia Varani; Fabrizio Vincenzi; Mojgan Aghazadeh Tabrizi
7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as selective CB(2) cannabinoid receptor ligands: structural investigations around a novel class of full agonists.
Journal of medicinal chemistry 2012;55(14):6608-23.
2012: Pier Giovanni Baraldi; Pier Andrea Borea; Delia Preti; Katia Varani
Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications.
Journal of medicinal chemistry 2012;55(12):5676-703.
2012: Romeo Romagnoli; Maria Kimatrai Salvador; Su-zhan Zhang; Mojgan Aghazadeh Tabrizi; Pier Giovanni Baraldi; Giuseppe Basso; Roberta Bortolozzi; Andrea Brancale; Xian-Hua Fu; Ernest Hamel; Jun Li; Elena Porcù; Delia Preti; Giampietro Viola
Discovery and optimization of a series of 2-aryl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazoles as novel anticancer agents.
Journal of medicinal chemistry 2012;55(11):5433-45.
2012: Pier Giovanni Baraldi; Stefania Baraldi; Pier Andrea Borea; Sandro Cosconati; Salvatore Di Maro; Stefania Gessi; Luciana Marinelli; Stefania Merighi; Allan R Moorman; Romeo Romagnoli; Giulia Saponaro; Katia Varani; Mojgan Aghazadeh Tabrizi; Delia Preti
Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A₃ adenosine receptor antagonists.
Journal of medicinal chemistry 2012;55(11):5380-90.
2012: Pier Giovanni Baraldi; Stefania Baraldi; Camilla Fusi; Pierangelo Geppetti; Serena Materazzi; Romina Nassini; Pamela Pedretti; Romeo Romagnoli; Giulia Saponaro; Mojgan Aghazadeh Tabrizi; Delia Preti
7-Substituted-pyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as antagonists of the transient receptor potential ankyrin 1 (TRPA1) channel: a promising approach for treating pain and inflammation.
Bioorganic & medicinal chemistry 2012;20(5):1690-8.
2012: Pier Giovanni Baraldi; Stefania Baraldi; Pier Andrea Borea; Andrea Cavalli; Allan R Moorman; Laura Piccagli; Delia Preti; Maurizio Recanatini; Romeo Romagnoli; Giulia Saponaro; Katia Varani; Abdel Naser Zaid; Mojgan Aghazadeh Tabrizi
Novel 1,3-dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl)xanthines as potent and selective A₂B adenosine receptor antagonists.
Journal of medicinal chemistry 2012;55(2):797-811.
2012: Pier Giovanni Baraldi; Stefania Baraldi; Pier Andrea Borea; Allan R Moorman; LUISA-CARLOTA LÓPEZ-CARA; Giulia Saponaro; Katia Varani; Mojgan Aghazadeh Tabrizi; Delia Preti
Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2012;20(2):1046-59.
2012: Romeo Romagnoli; Maria Kimatrai Salvador; John C Shryock; Mojgan Aghazadeh Tabrizi; Katia Varani; Fabrizio Vincenzi; LUISA-CARLOTA LÓPEZ-CARA; Maria Dora Carrion; Olga Cruz-Lopez; Allan R Moorman; Delia Preti; Pier Giovanni Baraldi; Pier Andrea Borea
Structure-activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1-yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A₁ adenosine receptor.
Bioorganic & medicinal chemistry 2012;20(2):996-1007.
2011: Romeo Romagnoli; Giampietro Viola; Su-zhan Zhang; Maria Kimatrai Salvador; Jun Li; LUISA-CARLOTA LÓPEZ-CARA; Jan Balzarini; Pier Giovanni Baraldi; Giuseppe Basso; Roberta Bortolozzi; Andrea Brancale; Xian-Hua Fu; Ernest Hamel
One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazole: a unique, highly active antimicrotubule agent.
European journal of medicinal chemistry 2011;46(12):6015-24.
2011: Romeo Romagnoli; Jae Gwan Kim; Maria Kimatrai Salvador; LUISA-CARLOTA LÓPEZ-CARA; Antonio Ricci; Jan Balzarini; Pier Giovanni Baraldi; Jaime Bermejo; Andrea Brancale; Maria Dora Carrion; Longchuan Chen; Olga Cruz-Lopez; Francisco Estévez; Sara Estévez; Ernest Hamel
Synthesis and antitumor molecular mechanism of agents based on amino 2-(3',4',5'-trimethoxybenzoyl)benzo[b]furan: inhibition of tubulin and induction of apoptosis.
ChemMedChem 2011;6(10):1841-53.
2011: Pier Giovanni Baraldi; Stefania Baraldi; Sandro Cosconati; Salvatore Di Maro; Luciana Marinelli; Allan R Moorman; Ettore Novellino; Delia Preti; LUISA-CARLOTA LÓPEZ-CARA; Giulia Saponaro; Mojgan Aghazadeh Tabrizi; Katia Varani; Abdel Naser Zaid; Pier Andrea Borea
New 2-heterocyclyl-imidazo[2,1-i]purin-5-one derivatives as potent and selective human A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2011;54(14):5205-20.
2011: LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Giuseppe Basso; Roberta Bortolozzi; Andrea Brancale; Ernest Hamel; Antonio Ricci; Giampietro Viola
Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents.
Journal of medicinal chemistry 2011;54(14):5144-53.
2011: LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Olga Cruz-Lopez; Manlio Tolomeo; Rosaria Maria Pipitone; Stefania Grimaudo; Jan Balzarini; Andrea Brancale; Antonietta Di Cristina; Ernest Hamel
Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives.
Bioorganic & medicinal chemistry letters 2011;21(9):2746-51.
2010: LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Carlota Lopez Cara; Ernest Hamel; Giuseppe Basso; Roberta Bortolozzi; Giampietro Viola
Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents.
European journal of medicinal chemistry 2010;45(12):5781-91.
2010: LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Maria Giovanna Pavani; Olga Cruz-Lopez; Ernest Hamel; Jan Balzarini; Eleonora Brognara; Cristina Zuccato; Roberto Gambari
Synthesis and cellular pharmacology studies of a series of 2-amino-3-aroyl-4-substituted thiophene derivatives.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2010;6(6):329-43.
2010: Pier Giovanni Baraldi; Delia Preti; Serena Materazzi; Pierangelo Geppetti
Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.
Journal of medicinal chemistry 2010;53(14):5085-107.
2010: LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Maria Dora Carrion; Olga Cruz-Lopez; Manlio Tolomeo; Stefania Grimaudo; Antonietta Di Cristina; Maria Rosaria Pipitone; Jan Balzarini; Andrea Brancale; Ernest Hamel
Substituted 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors.
Bioorganic & medicinal chemistry 2010;18(14):5114-22.
2010: Romeo Romagnoli; Pier Giovanni Baraldi; Olga Cruz-Lopez; LUISA-CARLOTA LÓPEZ-CARA; Maria Dora Carrion; Andrea Brancale; Ernest Hamel; Longchuan Chen; Roberta Bortolozzi; Giuseppe Basso; Giampietro Viola
Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues.
Journal of medicinal chemistry 2010;53(10):4248-58.
2010: Stefania Gessi; Valeria Sacchetto; Eleonora Fogli; Stefania Merighi; Katia Varani; Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Edward Leung; Stephen Maclennan; Pier Andrea Borea
Modulation of metalloproteinase-9 in U87MG glioblastoma cells by A3 adenosine receptors.
Biochemical pharmacology 2010;79(10):1483-95.
2010: Sandro Cosconati; Luciana Marinelli; Roberta Trotta; Ada Virno; Stefano De Tito; Romeo Romagnoli; Bruno Pagano; Vittorio Limongelli; Concetta Giancola; Pier Giovanni Baraldi; Luciano Mayol; Ettore Novellino; Antonio Randazzo
Structural and conformational requisites in DNA quadruplex groove binding: another piece to the puzzle.
Journal of the American Chemical Society 2010;132(18):6425-33.
2010: Romeo Romagnoli; Pier Giovanni Baraldi; Olga Cruz-Lopez; LUISA-CARLOTA LÓPEZ-CARA; Maria Dora Carrion; Jan Balzarini; Ernest Hamel; Giuseppe Basso; Roberta Bortolozzi; Giampietro Viola
Symmetrical alpha-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation.
Bioorganic & medicinal chemistry letters 2010;20(9):2733-9.
2010: LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Stefania Gessi; Pier Andrea Borea; Stefania Merighi
Allosteric enhancers of A1 adenosine receptors: state of the art and new horizons for drug development.
Current medicinal chemistry 2010;17(30):3488-502.
2009: Karen S MacMillan; James P Lajiness; Carlota Lopez Cara; Romeo Romagnoli; William M Robertson; Inkyu Hwang; Pier Giovanni Baraldi; Dale L Boger
Synthesis and evaluation of a thio analogue of duocarmycin SA.
Bioorganic & medicinal chemistry letters 2009;19(24):6962-5.
2009: E Andrè; Raffaele Gatti; Marcello Trevisani; Delia Preti; Pier Giovanni Baraldi; Riccardo Patacchini; Pierangelo Geppetti
Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents.
British journal of pharmacology 2009;158(6):1621-8.
2009: Stefania Merighi; Carolina Simioni; Stefania Gessi; Katia Varani; Prisco Mirandola; Mojgan Aghazadeh Tabrizi; Pier Giovanni Baraldi; Pier Andrea Borea
A(2B) and A(3) adenosine receptors modulate vascular endothelial growth factor and interleukin-8 expression in human melanoma cells treated with etoposide and doxorubicin.
Neoplasia (New York, N.Y.) 2009;11(10):1064-73.
2009: LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Maria Dora Carrion; Carlota Lopez Cara; Olga Cruz-Lopez; Manlio Tolomeo; Stefania Grimaudo; Antonietta Di Cristina; Maria Rosaria Pipitone; Jan Balzarini; Nicola Zonta; Andrea Brancale; Ernest Hamel
Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization.
Bioorganic & medicinal chemistry 2009;17(19):6862-71.
2009: LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Olga Cruz-Lopez; Delia Preti; Jaime Bermejo; Francisco Estévez
alpha-Bromoacrylamido N-substituted isatin derivatives as potent inducers of apoptosis in human myeloid leukemia cells.
ChemMedChem 2009;4(10):1668-76.
2009: LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Maria Dora Carrion; Olga Cruz-Lopez; Carlota Lopez Cara; Giuseppe Basso; Giampietro Viola; Mohammed Khedr; Jan Balzarini; Siavosh Mahboobi; Andreas Sellmer; Andrea Brancale; Ernest Hamel
2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization.
Journal of medicinal chemistry 2009;52(17):5551-5.
2009: Jan Paeshuyse; Carine Letellier; Matheus Froeyen; Hélène Dutartre; Robert Vrancken; Bruno Canard; Erik De Clercq; Alain Gueiffier; Jean-Claude Teulade; Piet Herdewijn; Gerhard Puerstinger; Frank Koenen; Pierre Kerkhofs; Pier Giovanni Baraldi; Johan Neyts
A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.
Antiviral research 2009;82(3):141-7.
2009: Romeo Romagnoli; Pier Giovanni Baraldi; Maria Dora Carrion; Olga Cruz-Lopez; LUISA-CARLOTA LÓPEZ-CARA; Jan Balzarini; Ernest Hamel; Alessandro Canella; Enrica Fabbri; Roberto Gambari; Giuseppe Basso; Giampietro Viola
Hybrid alpha-bromoacryloylamido chalcones. Design, synthesis and biological evaluation.
Bioorganic & medicinal chemistry letters 2009;19(7):2022-8.
2009: Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Francesca Fruttarolo; LUISA-CARLOTA LÓPEZ-CARA; Delia Preti
Recent improvements in the development of A(2B) adenosine receptor agonists.
Purinergic signalling 2009;5(1):3-19.
2009: Kenneth Alan Jacobson; Athena M Klutz; Dilip K Tosh; Andrei A Ivanov; Delia Preti; Pier Giovanni Baraldi
Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering.
Handbook of experimental pharmacology 2009;(193):123-59.
2009: Rao V Kalla; Jeff Zablocki; Mojgan Aghazadeh Tabrizi; Pier Giovanni Baraldi
Recent developments in A2B adenosine receptor ligands.
Handbook of experimental pharmacology 2009;(193):99-122.
2009: Romeo Romagnoli; Pier Giovanni Baraldi; Olga Cruz-Lopez; LUISA-CARLOTA LÓPEZ-CARA; Delia Preti
alpha-halogenoacrylic derivatives of antitumor agents.
Mini reviews in medicinal chemistry 2009;9(1):81-94.
2008: Pier Giovanni Baraldi; Delia Preti; Mojgan Aghazadeh Tabrizi; LUISA-CARLOTA LÓPEZ-CARA; Giulia Saponaro; Stefania Baraldi; Maurizio Botta; Cesare Bernardini; Andrea Tafi; Tiziano Tuccinardi; Adriano Martinelli; Katia Varani; Pier Andrea Borea
Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2008;16(24):10281-94.
2008: Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Francesca Fruttarolo; LUISA-CARLOTA LÓPEZ-CARA; Delia Preti
Recent improvements in the development of A(2B) adenosine receptor agonists.
Purinergic signalling 2008;4(4):287-303.
2008: Romeo Romagnoli; Pier Giovanni Baraldi; Taradas Sarkar; LUISA-CARLOTA LÓPEZ-CARA; Olga Cruz Lopez; Maria Dora Carrion; Delia Preti; Manlio Tolomeo; Jan Balzarini; Ernest Hamel
Synthesis and biological evaluation of 2-aroyl-4-phenyl-5-hydroxybenzofurans as a new class of antitubulin agents.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2008;4(6):558-64.
2008: Romeo Romagnoli; Pier Giovanni Baraldi; Maria Dora Carrion; LUISA-CARLOTA LÓPEZ-CARA; Olga Cruz-Lopez; Maria Antonietta Iaconinoto; Delia Preti; John C Shryock; Allan R Moorman; Fabrizio Vincenzi; Katia Varani; Pier Andrea Borea
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor.
Journal of medicinal chemistry 2008;51(18):5875-9.
2008: Romeo Romagnoli; Pier Giovanni Baraldi; Taradas Sarkar; Maria Dora Carrion; Olga Cruz-Lopez; LUISA-CARLOTA LÓPEZ-CARA; Manlio Tolomeo; Stefania Grimaudo; Antonietta Di Cristina; Maria Rosaria Pipitone; Jan Balzarini; Roberto Gambari; Lampronti Ilaria; Roberto Saletti; Andrea Brancale; Ernest Hamel
Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization.
Bioorganic & medicinal chemistry 2008;16(18):8419-26.
2008: Romeo Romagnoli; Pier Giovanni Baraldi; Maria Dora Carrion; Olga Cruz-Lopez; LUISA-CARLOTA LÓPEZ-CARA; Manlio Tolomeo; Stefania Grimaudo; Antonietta Di Cristina; Maria Rosa Pipitone; Jan Balzarini; Sahar Kandil; Andrea Brancale; Taradas Sarkar; Ernest Hamel
Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerization.
Bioorganic & medicinal chemistry letters 2008;18(18):5041-5.
2008: Eunice Andrè; Barbara Campi; Serena Materazzi; Marcello Trevisani; Silvia Amadesi; Daniela Massi; Christophe Creminon; Natalya Vaksman; Romina Nassini; Maurizio Civelli; Pier Giovanni Baraldi; Daniel P Poole; Nigel W Bunnett; Pierangelo Geppetti; Riccardo Patacchini
Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents.
The Journal of clinical investigation 2008;118(7):2574-82.
2008: Romeo Romagnoli; Pier Giovanni Baraldi; Maria Dora Carrion; LUISA-CARLOTA LÓPEZ-CARA; Olga Cruz-Lopez; Delia Preti; Manlio Tolomeo; Stefania Grimaudo; Antonietta Di Cristina; Nicola Zonta; Jan Balzarini; Andrea Brancale; Taradas Sarkar; Ernest Hamel
Design, synthesis, and biological evaluation of thiophene analogues of chalcones.
Bioorganic & medicinal chemistry 2008;16(10):5367-76.
2008: Romeo Romagnoli; Pier Giovanni Baraldi; Olga Cruz-Lopez; LUISA-CARLOTA LÓPEZ-CARA; Delia Preti; Pier Andrea Borea; Stefania Gessi
The P2X7 receptor as a therapeutic target.
Expert opinion on therapeutic targets 2008;12(5):647-61.
2008: Romeo Romagnoli; Pier Giovanni Baraldi; Taradas Sarkar; Maria Dora Carrion; LUISA-CARLOTA LÓPEZ-CARA; Olga Cruz-Lopez; Delia Preti; Mojgan Aghazadeh Tabrizi; Manlio Tolomeo; Stefania Grimaudo; Antonietta Di Cristina; Nicola Zonta; Jan Balzarini; Andrea Brancale; Hsing-Pang Hsieh; Ernest Hamel
Synthesis and biological evaluation of 1-methyl-2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors.
Journal of medicinal chemistry 2008;51(5):1464-8.
2008: Mojgan Aghazadeh Tabrizi; Pier Giovanni Baraldi; Delia Preti; LUISA-CARLOTA LÓPEZ-CARA; Giulia Saponaro; Stefania Baraldi; Allan R Moorman; Abdel Naser Zaid; Katia Varani; Pier Andrea Borea
1,3-Dipropyl-8-(1-phenylacetamide-1H-pyrazol-3-yl)-xanthine derivatives as highly potent and selective human A(2B) adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2008;16(5):2419-30.
2008: Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Stefania Gessi; Pier Andrea Borea
Adenosine receptor antagonists: translating medicinal chemistry and pharmacology into clinical utility.
Chemical reviews 2008;108(1):238-63.
2007: Mark S Tichenor; Karen S MacMillan; James S Stover; Scott E Wolkenberg; Maria G Pavani; Lorenzo Zanella; Abdel N Zaid; Gianpiero Spalluto; Thomas J Rayl; Inhwan Hwang; Pier Giovanni Baraldi; Dale L Boger
Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.
Journal of the American Chemical Society 2007;129(45):14092-9.
2007: Romeo Romagnoli; Pier Giovanni Baraldi; Vincent Remusat; Maria Dora Carrion; LUISA-CARLOTA LÓPEZ-CARA; Olga Cruz-Lopez; Delia Preti; Francesca Fruttarolo; Mojgan Aghazadeh Tabrizi; Jan Balzarini; Ernest Hamel
Synthesis and biological evaluation of 2-amino-3-(3', 4', 5'-trimethoxy-phenylsulfonyl)-5-aryl thiophenes as a new class of antitubulin agents.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2007;3(6):507-12.
2007: Stefania Merighi; Annalisa Benini; Prisco Mirandola; Stefania Gessi; Katia Varani; Carolina Simioni; Edward Leung; Stephen Maclennan; Pier Giovanni Baraldi; Pier Andrea Borea
Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells.
Molecular pharmacology 2007;72(2):395-406.
2007: Romeo Romagnoli; Pier Giovanni Baraldi; Maria Dora Carrion; LUISA-CARLOTA LÓPEZ-CARA; Delia Preti; Olga Cruz-Lopez; Mojgan Aghazadeh Tabrizi; Allan R Moorman; Stefania Gessi; Eleonora Fogli; Valeria Sacchetto; Pier Andrea Borea
From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor.
Journal of medicinal chemistry 2007;50(15):3706-15.
2007: Stefania Merighi; Annalisa Benini; Prisco Mirandola; Stefania Gessi; Katia Varani; Edward Leung; Stephen Maclennan; Pier Giovanni Baraldi; Pier Andrea Borea
Hypoxia inhibits paclitaxel-induced apoptosis through adenosine-mediated phosphorylation of bad in glioblastoma cells.
Molecular pharmacology 2007;72(1):162-72.
2007: Pier Giovanni Baraldi; Maria Antonietta Iaconinoto; Allan R Moorman; Maria Dora Carrion; LUISA-CARLOTA LÓPEZ-CARA; Delia Preti; Olga Cruz López; Francesca Fruttarolo; Mojgan Aghazadeh Tabrizi; Romeo Romagnoli
Allosteric enhancers for A1 adenosine receptor.
Mini reviews in medicinal chemistry 2007;7(6):559-69.
2007: LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Maria Dora Carrion; Olga Cruz-Lopez; Delia Preti; Mojgan Aghazadeh Tabrizi; Francesca Fruttarolo; Jörg Heilmann; Jaime Bermejo; Francisco Estévez
Hybrid molecules containing benzo[4,5]imidazo[1,2-d][1,2,4]thiadiazole and alpha-bromoacryloyl moieties as potent apoptosis inducers on human myeloid leukaemia cells.
Bioorganic & medicinal chemistry letters 2007;17(10):2844-8.
2007: Romeo Romagnoli; Pier Giovanni Baraldi; Maria Dora Carrion; LUISA-CARLOTA LÓPEZ-CARA; Delia Preti; Francesca Fruttarolo; Maria Giovanna Pavani; Mojgan Aghazadeh Tabrizi; Manlio Tolomeo; Stefania Grimaudo; Antonietta Di Cristina; Jan Balzarini; John A Hadfield; Andrea Brancale; Ernest Hamel
Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization.
Journal of medicinal chemistry 2007;50(9):2273-7.
2007: Pier Giovanni Baraldi; Delia Preti; Mojgan Aghazadeh Tabrizi; Francesca Fruttarolo; Giulia Saponaro; Stefania Baraldi; LUISA-CARLOTA LÓPEZ-CARA; Allan R Moorman; Stefania Gessi; Katia Varani; Pier Andrea Borea
N(6)-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5'-N-ethylcarboxamido-adenosines: the first example of adenosine-related structures with potent agonist activity at the human A(2B) adenosine receptor.
Bioorganic & medicinal chemistry 2007;15(7):2514-27.
2007: Pier Giovanni Baraldi; Delia Preti; Mojgan Aghazadeh Tabrizi; Francesca Fruttarolo; LUISA-CARLOTA LÓPEZ-CARA; Maria Dora Carrion; Luisa Carlota Lopez Cara; Allan R Moorman; Katia Varani; Pier Andrea Borea
Synthesis and biological evaluation of novel 1-deoxy-1-[6-[((hetero)arylcarbonyl)hydrazino]- 9H-purin-9-yl]-N-ethyl-beta-D-ribofuranuronamide derivatives as useful templates for the development of A2B adenosine receptor agonists.
Journal of medicinal chemistry 2007;50(2):374-80.
2007: Pier Giovanni Baraldi; Delia Preti; Francesca Fruttarolo; Mojgan Aghazadeh Tabrizi; LUISA-CARLOTA LÓPEZ-CARA
Hybrid molecules between distamycin A and active moieties of antitumor agents.
Bioorganic & medicinal chemistry 2007;15(1):17-35.
2006: Stefania Merighi; Annalisa Benini; Prisco Mirandola; Stefania Gessi; Katia Varani; Edward Leung; Stephen Maclennan; Pier Giovanni Baraldi; Pier Andrea Borea
Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A₃ adenosine receptor.
Purinergic signalling 2006;2(4):627-32.
2006: Stefania Gessi; Katia Varani; Stefania Merighi; Edward Leung; Stephen Mac Lennan; Pier Giovanni Baraldi; Pier Andrea Borea
Novel selective antagonist radioligands for the pharmacological study of A(2B) adenosine receptors.
Purinergic signalling 2006;2(4):583-8.
2006: Romeo Romagnoli; Pier Giovanni Baraldi; Allan R Moorman; Maria Antonietta Iaconinoto; Maria Dora Carrion; LUISA-CARLOTA LÓPEZ-CARA; Mojgan Aghazadeh Tabrizi; Delia Preti; Francesca Fruttarolo; Stephen P Baker; Katia Varani; Pier Andrea Borea
Microwave-assisted synthesis of thieno[2,3-c]pyridine derivatives as a new series of allosteric enhancers at the adenosine A(1) receptor.
Bioorganic & medicinal chemistry letters 2006;16(21):5530-3.
2006: Romeo Romagnoli; Pier Giovanni Baraldi; Vincent Remusat; Maria Dora Carrion; LUISA-CARLOTA LÓPEZ-CARA; Delia Preti; Francesca Fruttarolo; Maria Giovanna Pavani; Mojgan Aghazadeh Tabrizi; Manlio Tolomeo; Stefania Grimaudo; Jan Balzarini; Mary Ann Jordan; Ernest Hamel
Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors.
Journal of medicinal chemistry 2006;49(21):6425-8.
2006: Andrea Tafi; Cesare Bernardini; Maurizio Botta; Federico Corelli; Matteo Andreini; Adriano Martinelli; Gabriella Ortore; Pier Giovanni Baraldi; Francesca Fruttarolo; Pier Andrea Borea; Tiziano Tuccinardi
Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models.
Journal of medicinal chemistry 2006;49(14):4085-97.
2006: LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Maria Giovanna Pavani; Mojgan Aghazadeh Tabrizi; Delia Preti; Francesca Fruttarolo; Laura Piccagli; M Katherine Jung; Ernest Hamel; Monica Borgatti; Roberto Gambari
Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents.
Journal of medicinal chemistry 2006;49(13):3906-15.
2006: Giorgia Pastorin; Tatiana Da Ros; Chiara Bolcato; Christian Montopoli; Stefano Moro; Barbara Cacciari; Pier Giovanni Baraldi; Katia Varani; Pier Andrea Borea; Giampiero Spalluto
Synthesis and biological studies of a new series of 5-heteroarylcarbamoylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists. Influence of the heteroaryl substituent on binding affinity and molecular modeling investigations.
Journal of medicinal chemistry 2006;49(5):1720-9.
2006: Pier Giovanni Baraldi; Maria Giovanna Pavani; Edward Leung; Allan R Moorman; Katia Varani; Fabrizio Vincenzi; Pier Andrea Borea; LUISA-CARLOTA LÓPEZ-CARA
Synthesis and biological characterization of [3H] (2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(4-chlorophenyl)-methanone, the first radiolabelled adenosine A1 allosteric enhancer.
Bioorganic & medicinal chemistry letters 2006;16(5):1402-4.
2006: Alessia Melani; Marco Gianfriddo; Maria Giuliana Vannucchi; Sara Cipriani; Pier Giovanni Baraldi; Maria Grazia Giovannini; Felicita Pedata
The selective A2A receptor antagonist SCH 58261 protects from neurological deficit, brain damage and activation of p38 MAPK in rat focal cerebral ischemia.
Brain research 2006;1073-1074():470-80.
2006: Pier Giovanni Baraldi; LUISA-CARLOTA LÓPEZ-CARA; Delia Preti; Francesca Fruttarolo; Maria Dora Carrion; Mojgan Aghazadeh Tabrizi
Ligands for A2B adenosine receptor subtype.
Current medicinal chemistry 2006;13(28):3467-82.
2005: LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Jaime Bermejo; Francisco Estévez; Monica Borgatti; Roberto Gambari
Design, synthesis, and biological evaluation of hybrid molecules containing alpha-methylene-gamma-butyrolactones and alpha-bromoacryloyl moieties.
Journal of medicinal chemistry 2005;48(24):7906-10.
2005: Letizia Penolazzi; Ercolina Bianchini; Elisabetta Lambertini; Pier Giovanni Baraldi; LUISA-CARLOTA LÓPEZ-CARA; Roberta Piva; Roberto Gambari
N-Arylpiperazine modified analogues of the P2X7 receptor KN-62 antagonist are potent inducers of apoptosis of human primary osteoclasts.
Journal of biomedical science 2005;12(6):1013-20.
2005: Katia Varani; Stefania Gessi; Stefania Merighi; Fabrizio Vincenzi; Elena Cattabriga; Annalisa Benini; Karl-Norbert Klotz; Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Stephen Mac Lennan; Edward Leung; Pier Andrea Borea
Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors.
Biochemical pharmacology 2005;70(11):1601-12.
2005: Andrei A Ivanov; Igor Baskin; Vladimir A Palyulin; Laura Piccagli; Pier Giovanni Baraldi; Nikolai S Zefirov
Molecular modeling and molecular dynamics simulation of the human A2B adenosine receptor. The study of the possible binding modes of the A2B receptor antagonists.
Journal of medicinal chemistry 2005;48(22):6813-20.
2005: LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Maria Antonietta Iaconinoto; Maria Dora Carrion; Mojgan Aghazadeh Tabrizi; Roberto Gambari; Monica Borgatti; Jörg Heilmann
Synthesis and biological activity of alpha-bromoacryloyl lexitropsin conjugates.
European journal of medicinal chemistry 2005;40(11):1123-8.
2005: Stefania Merighi; Annalisa Benini; Prisco Mirandola; Stefania Gessi; Katia Varani; Edward Leung; Stephen Maclennan; Pier Giovanni Baraldi; Pier Andrea Borea
A3 adenosine receptors modulate hypoxia-inducible factor-1alpha expression in human A375 melanoma cells.
Neoplasia (New York, N.Y.) 2005;7(10):894-903.
2005: LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; M Katherine Jung; Maria Antonietta Iaconinoto; Maria Dora Carrion; Vincent Remusat; Delia Preti; Mojgan Aghazadeh Tabrizi; Fruttarolo Francesca; Erik De Clercq; Jan Balzarini; Ernest Hamel
Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles.
Bioorganic & medicinal chemistry letters 2005;15(18):4048-52.
2005: Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Delia Preti; Andrea Bovero; Francesca Fruttarolo; LUISA-CARLOTA LÓPEZ-CARA; Naser Abdel Zaid; Allan R Moorman; Katia Varani; Pier Andrea Borea
New 2-arylpyrazolo[4,3-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2005;48(15):5001-8.
2005: Pier Giovanni Baraldi; Delia Preti; Mojgan Aghazadeh Tabrizi; Francesca Fruttarolo; LUISA-CARLOTA LÓPEZ-CARA; Naser Abdel Zaid; Allan R Moorman; Stefania Merighi; Katia Varani; Pier Andrea Borea
New pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2005;48(14):4697-701.
2005: Stefania Gessi; Katia Varani; Stefania Merighi; Elena Cattabriga; Cecilia Pancaldi; Youri Szabadkai; Rosario Rizzuto; Karl-Norbert Klotz; Edward Leung; Stephen Mac Lennan; Pier Giovanni Baraldi; Pier Andrea Borea
Expression, pharmacological profile, and functional coupling of A2B receptors in a recombinant system and in peripheral blood cells using a novel selective antagonist radioligand, [3H]MRE 2029-F20.
Molecular pharmacology 2005;67(6):2137-47.
2005: Pier Giovanni Baraldi; LUISA-CARLOTA LÓPEZ-CARA; Mojgan Aghazadeh Tabrizi; Andrea Bovero; Delia Preti; Francesca Fruttarolo; Allan R Moorman; Pier Andrea Borea
New heterocyclic ligands for the adenosine receptors P1 and for the ATP receptors P2.
Farmaco (Società chimica italiana : 1989) 2005;60(3):185-202.
2005: Francesco Di Virgilio; Olavio R Baricordi; LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi
Leukocyte P2 receptors: a novel target for anti-inflammatory and anti-tumor therapy.
Current drug targets. Cardiovascular & haematological disorders 2005;5(1):85-99.
2005: Stefano Moro; Paolo Braiuca; Francesca Deflorian; Cristina Ferrari; Giorgia Pastorin; Barbara Cacciari; Pier Giovanni Baraldi; Katia Varani; Pier Andrea Borea; Giampiero Spalluto
Combined target-based and ligand-based drug design approach as a tool to define a novel 3D-pharmacophore model of human A3 adenosine receptor antagonists: pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as a key study.
Journal of medicinal chemistry 2005;48(1):152-62.
2005: Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; LUISA-CARLOTA LÓPEZ-CARA; Francesca Fruttarolo; Stefania Merighi; Katia Varani; Stefania Gessi; Pier Andrea Borea
Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine ligands, new tools to characterize A3 adenosine receptors in human tumor cell lines.
Current medicinal chemistry 2005;12(11):1319-29.
2004: LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Maria Giovanna Pavani; Mojgan Aghazadeh Tabrizi; Allan R Moorman; Francesco Di Virgilio; Elena Cattabriga; Cecilia Pancaldi; Stefania Gessi; Pier Andrea Borea
Synthesis, radiolabeling, and preliminary biological evaluation of [3H]-1-[(S)-N,O-bis-(isoquinolinesulfonyl)-N-methyl-tyrosyl]-4-(o-tolyl)-piperazine, a potent antagonist radioligand for the P2X7 receptor.
Bioorganic & medicinal chemistry letters 2004;14(22):5709-12.
2004: Pier Giovanni Baraldi; Francesca Fruttarolo; Mojgan Aghazadeh Tabrizi; LUISA-CARLOTA LÓPEZ-CARA; Delia Preti; Andrea Bovero; Maria Josè Pineda de las Infantas; Allan Moorman; Katia Varani; Pier Andrea Borea
Synthesis and biological evaluation of novel N6-[4-(substituted)sulfonamidophenylcarbamoyl]adenosine-5'-uronamides as A3 adenosine receptor agonists.
Journal of medicinal chemistry 2004;47(22):5535-40.
2004: Pier Giovanni Baraldi; Maria Giovanna Pavani; John C Shryock; Allan R Moorman; Valeria Iannotta; Pier Andrea Borea; LUISA-CARLOTA LÓPEZ-CARA
Synthesis of 2-amino-3-heteroaroylthiophenes and evaluation of their activity as potential allosteric enhancers at the human A1 receptor.
European journal of medicinal chemistry 2004;39(10):855-65.
2004: Pier Giovanni Baraldi; Italo Beria; Paolo Cozzi; Cristina Geroni; Antonio Espinosa; Miguel A Gallo; Antonio Entrena; John P Bingham; John A Hartley; LUISA-CARLOTA LÓPEZ-CARA
Cinnamoyl nitrogen mustard derivatives of pyrazole analogues of tallimustine modified at the amidino moiety: design, synthesis, molecular modeling and antitumor activity studies.
Bioorganic & medicinal chemistry 2004;12(14):3911-21.
2004: Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Delia Preti; Andrea Bovero; Francesca Fruttarolo; LUISA-CARLOTA LÓPEZ-CARA; Allan R Moorman; Stefania Gessi; Stefania Merighi; Katia Varani; Pier Andrea Borea
[3H]-MRE 2029-F20, a selective antagonist radioligand for the human A2B adenosine receptors.
Bioorganic & medicinal chemistry letters 2004;14(13):3607-10.
2004: Pier Giovanni Baraldi; Andrea Bovero; Francesca Fruttarolo; Delia Preti; Mojgan Aghazadeh Tabrizi; Maria Giovanna Pavani; LUISA-CARLOTA LÓPEZ-CARA
DNA minor groove binders as potential antitumor and antimicrobial agents.
Medicinal research reviews 2004;24(4):475-528.
2004: Pier Giovanni Baraldi; Maria Del Carmen Nunez; Mojgan Aghazadeh Tabrizi; Erik De Clercq; Jan Balzarini; Jaime Bermejo; Francisco Estévez; LUISA-CARLOTA LÓPEZ-CARA
Design, synthesis, and biological evaluation of hybrid molecules containing alpha-methylene-gamma-butyrolactones and polypyrrole minor groove binders.
Journal of medicinal chemistry 2004;47(11):2877-86.
2004: Italo Beria; Pier Giovanni Baraldi; Paolo Cozzi; Marina Caldarelli; Cristina Geroni; Sergio Marchini; Nicola Mongelli; LUISA-CARLOTA LÓPEZ-CARA
Cytotoxic alpha-halogenoacrylic derivatives of distamycin A and congeners.
Journal of medicinal chemistry 2004;47(10):2611-23.
2004: Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Delia Preti; Andrea Bovero; LUISA-CARLOTA LÓPEZ-CARA; Francesca Fruttarolo; Naser Abdel Zaid; Allan R Moorman; Katia Varani; Stefania Gessi; Stefania Merighi; Pier Andrea Borea
Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists.
Journal of medicinal chemistry 2004;47(6):1434-47.
2004: Carlo Mischiati; Alessia Finotti; Alessia Sereni; Sindi Boschetti; Pier Giovanni Baraldi; LUISA-CARLOTA LÓPEZ-CARA; Giordana Feriotto; Kuan-Teh Jeang; Nicoletta Bianchi; Monica Borgatti; Roberto Gambari
Binding of hybrid molecules containing pyrrolo [2,1-c][1,4]benzodiazepine (PBD) and oligopyrrole carriers to the human immunodeficiency type 1 virus TAR-RNA.
Biochemical pharmacology 2004;67(3):401-10.
2004: Pier Giovanni Baraldi; LUISA-CARLOTA LÓPEZ-CARA; Maria Del Carmen Nuñez; Mauro Perretti; Mark Paul-Clark; Massimiliano Ferrario; Mirco Govoni; Francesca Benedini; Ennio Ongini
Synthesis of nitro esters of prednisolone, new compounds combining pharmacological properties of both glucocorticoids and nitric oxide.
Journal of medicinal chemistry 2004;47(3):711-9.
2004: Pier Giovanni Baraldi; Francesco Di Virgilio; LUISA-CARLOTA LÓPEZ-CARA
Agonists and antagonists acting at P2X7 receptor.
Current topics in medicinal chemistry 2004;4(16):1707-17.
2004: Pier Giovanni Baraldi; Maria del Carmen Nûnez; Antonio Espinosa; LUISA-CARLOTA LÓPEZ-CARA
Distamycin A as stem of DNA minor groove alkylating agents.
Current topics in medicinal chemistry 2004;4(2):231-9.
2003: Alessandra Boschi; Licia Uccelli; Adriano Duatti; Cristina Bolzati; Fiorenzo Refosco; Francesco Tisato; LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Katia Varani; Pier Andrea Borea
Asymmetrical nitrido tc-99m heterocomplexes as potential imaging agents for benzodiazepine receptors.
Bioconjugate chemistry 2003;14(6):1279-88.
2003: Stefania Merighi; Prisco Mirandola; Katia Varani; Stefania Gessi; Edward Leung; Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Pier Andrea Borea
A glance at adenosine receptors: novel target for antitumor therapy.
Pharmacology & therapeutics 2003;100(1):31-48.
2003: Giorgia Pastorin; Tatiana Da Ros; Giampiero Spalluto; Francesca Deflorian; Stefano Moro; Barbara Cacciari; Pier Giovanni Baraldi; Stefania Gessi; Katia Varani; Pier Andrea Borea
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A 3 and A 2B adenosine receptor subtypes: a molecular modeling investigation.
Journal of medicinal chemistry 2003;46(20):4287-96.
2003: Pier Giovanni Baraldi; Andrea Bovero; Francesca Fruttarolo; LUISA-CARLOTA LÓPEZ-CARA; Mojgan Aghazadeh Tabrizi; Delia Preti; Katia Varani; Pier Andrea Borea; Allan R Moorman
New strategies for the synthesis of A3 adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2003;11(19):4161-9.
2003: Stefania Merighi; Prisco Mirandola; Katia Varani; Stefania Gessi; Silvano Capitani; Edward Leung; Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Pier Andrea Borea
Pyrazolotriazolopyrimidine derivatives sensitize melanoma cells to the chemotherapic drugs: taxol and vindesine.
Biochemical pharmacology 2003;66(5):739-48.
2003: Pier Giovanni Baraldi; LUISA-CARLOTA LÓPEZ-CARA; Nicoletta Bianchi; Roberto Gambari
Benzoyl nitrogen mustard derivatives of benzoheterocyclic analogues of netropsin: synthesis and biological activity.
Bioorganic & medicinal chemistry 2003;11(11):2381-8.
2003: Pier Giovanni Baraldi; Maria del Carmen Nuñez; Anna Morelli; Simonetta Falzoni; Francesco Di Virgilio; Romeo Romagnoli
Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor.
Journal of medicinal chemistry 2003;46(8):1318-29.
2003: Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Andrea Bovero; Barbara Avitabile; Delia Preti; Francesca Fruttarolo; LUISA-CARLOTA LÓPEZ-CARA; Katia Varani; Pier Andrea Borea
Recent developments in the field of A2A and A3 adenosine receptor antagonists.
European journal of medicinal chemistry 2003;38(4):367-82.
2003: Pier Giovanni Baraldi; Francesca Fruttarolo; Mojgan Aghazadeh Tabrizi; Delia Preti; LUISA-CARLOTA LÓPEZ-CARA; Hussein El-Kashef; Allan Moorman; Katia Varani; Stefania Gessi; Stefania Merighi; Pier Andrea Borea
Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.
Journal of medicinal chemistry 2003;46(7):1229-41.
2003: Pier Giovanni Baraldi; Italo Beria; Paolo Cozzi; Nicoletta Bianchi; Roberto Gambari; LUISA-CARLOTA LÓPEZ-CARA
Synthesis and growth inhibition activity of alpha-bromoacrylic heterocyclic and benzoheterocyclic derivatives of distamycin A modified on the amidino moiety.
Bioorganic & medicinal chemistry 2003;11(6):965-75.
2003: Pier Giovanni Baraldi; LUISA-CARLOTA LÓPEZ-CARA; Maria Giovanna Pavani; Maria del Carmen Nuñez; Mojgan Aghazadeh Tabrizi; John C Shryock; Edward Leung; Allan R Moorman; Canan Uluoglu; Valeria Iannotta; Stefania Merighi; Pier Andrea Borea
Synthesis and biological effects of novel 2-amino-3-naphthoylthiophenes as allosteric enhancers of the A1 adenosine receptor.
Journal of medicinal chemistry 2003;46(5):794-809.
2003: Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Maria Giovanna Pavani; Maria del Carmen Nuñez; Rimma Makaeva; Roberto Gambari; Paolo La Colla; LUISA-CARLOTA LÓPEZ-CARA
Design, synthesis and in vitro cytotoxicity of a cis-dichloroplatinum (II) complex linked to the minor groove binder stallimycin.
Arzneimittel-Forschung 2003;53(2):107-13.
2002: Stefania Merighi; Prisco Mirandola; Daniela Milani; Katia Varani; Stefania Gessi; Karl-Norbert Klotz; Edward Leung; Pier Giovanni Baraldi; Pier Andrea Borea
Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells.
The Journal of investigative dermatology 2002;119(4):923-33.
2002: Pier Giovanni Baraldi; LUISA-CARLOTA LÓPEZ-CARA; Antonio Entrena Guadix; Maria Josè Pineda de las Infantas; Miguel A Gallo; Antonio Espinosa; Alberto Martinez; John P Bingham; John A Hartley
Design, synthesis, and biological activity of hybrid compounds between uramustine and DNA minor groove binder distamycin A.
Journal of medicinal chemistry 2002;45(17):3630-8.
2002: Anna Maconi; Giorgia Pastorin; Tatiana Da Ros; Giampiero Spalluto; Zhan-Guo Gao; Kenneth Alan Jacobson; Pier Giovanni Baraldi; Barbara Cacciari; Katia Varani; Stefano Moro; Pier Andrea Borea
Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist.
Journal of medicinal chemistry 2002;45(17):3579-82.
2002: Pier Giovanni Baraldi; LUISA-CARLOTA LÓPEZ-CARA; Maria Giovanna Pavani; Maria del Carmen Nunez; John P Bingham; John A Hartley
Benzoyl and cinnamoyl nitrogen mustard derivatives of benzoheterocyclic analogues of the tallimustine: synthesis and antitumour activity.
Bioorganic & medicinal chemistry 2002;10(5):1611-8.
2002: Pier Giovanni Baraldi; Barbara Cacciari; Stefano Moro; Giampiero Spalluto; Giorgia Pastorin; Tatiana Da Ros; Karl-Norbert Klotz; Katia Varani; Stefania Gessi; Pier Andrea Borea
Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists.
Journal of medicinal chemistry 2002;45(4):770-80.
2002: Stefania Gessi; Katia Varani; Stefania Merighi; Elena Cattabriga; Valeria Iannotta; Edward Leung; Pier Giovanni Baraldi; Pier Andrea Borea
A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: a pharmacological and biochemical study.
Molecular pharmacology 2002;61(2):415-24.
2002: Pier Giovanni Baraldi; Maria Giovanna Pavani; Maria del Carmen Nuñez; Patrizia Brigidi; Beatrice Vitali; Roberto Gambari; LUISA-CARLOTA LÓPEZ-CARA
Antimicrobial and antitumor activity of N-heteroimmine-1,2,3-dithiazoles and their transformation in triazolo-, imidazo-, and pyrazolopirimidines.
Bioorganic & medicinal chemistry 2002;10(2):449-56.
2002: Stefania Merighi; Katia Varani; Stefania Gessi; Karl-Norbert Klotz; Edward Leung; Pier Giovanni Baraldi; Pier Andrea Borea
Binding thermodynamics at the human A(3) adenosine receptor.
Biochemical pharmacology 2002;63(2):157-61.
2002: Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Angela Monopoli; Ennio Ongini; Katia Varani; Pier Andrea Borea
7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: a study on the importance of modifications at the side chain on the activity and solubility.
Journal of medicinal chemistry 2002;45(1):115-26.
2002: Pier Giovanni Baraldi; Barbara Cacciari; Pier Andrea Borean; Katia Varanin; Giorgia Pastorin; Tatiana Da Ros; Mojgan Aghazadeh Tabrizi; Francesca Fruttarolo; Giampiero Spalluto
Pyrazolo-triazolo-pyrimidine derivatives as adenosine receptor antagonists: a possible template for adenosine receptor subtypes?
Current pharmaceutical design 2002;8(26):2299-332.
2002: Pier Giovanni Baraldi; Rimma Makaeva; Maria Giovanna Pavani; Maria del Carmen Nuñez; Giampiero Spalluto; Stefano Moro; Simonetta Falzoni; Francesco Di Virgilio; LUISA-CARLOTA LÓPEZ-CARA
Synthesis, biological activity and molecular modeling studies of 1,2,3,4-tetrahydroisoquinoline derivatives as conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor containing a tyrosine moiety.
Arzneimittel-Forschung 2002;52(4):273-85.
2001: Stefania Gessi; Katia Varani; Stefania Merighi; Antonio Morelli; Davide Ferrari; Edward Leung; Pier Giovanni Baraldi; Giampiero Spalluto; Pier Andrea Borea
Pharmacological and biochemical characterization of A3 adenosine receptors in Jurkat T cells.
British journal of pharmacology 2001;134(1):116-26.
2001: Pier Giovanni Baraldi; Barbara Cacciari; Stefano Moro; LUISA-CARLOTA LÓPEZ-CARA; Kenneth Alan Jacobson; Stefania Gessi; Pier Andrea Borea; Giampiero Spalluto
Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies.
Journal of medicinal chemistry 2001;44(17):2735-42.
2001: Pier Giovanni Baraldi; Gianfranco Balboni; Maria Giovanna Pavani; Giampiero Spalluto; Mojgan Aghazadeh Tabrizi; E D Clercq; Jan Balzarini; T Bando; H Sugiyama; LUISA-CARLOTA LÓPEZ-CARA
Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.
Journal of medicinal chemistry 2001;44(16):2536-43.
2001: Stefano Manfredini; Pier Giovanni Baraldi; Elisa Durini; L Porcu; Angela Angusti; Silvia Vertuani; Nicola Solaroli; Erik De Clercq; Anna Karlsson; Jan Balzarini
Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(10):1329-32.
2000: Pier Giovanni Baraldi; Pier Andrea Borea
New potent and selective human adenosine A(3) receptor antagonists.
Trends in pharmacological sciences 2000;21(12):456-9.
2000: Pier Giovanni Baraldi; Abdel N Zaid; I Lampronti; Francesca Fruttarolo; Maria Giovanna Pavani; Mojgan Aghazadeh Tabrizi; John C Shryock; Edward Leung; LUISA-CARLOTA LÓPEZ-CARA
Synthesis and biological effects of a new series of 2-amino-3-benzoylthiophenes as allosteric enhancers of A1-adenosine receptor.
Bioorganic & medicinal chemistry letters 2000;10(17):1953-7.
2000: Pier Giovanni Baraldi; Barbara Cacciari; Andrea Guiotto; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; A Leoni; Nicoletta Bianchi; Giordana Feriotto; Cristina Rutigliano; Carlo Mischiati; Roberto Gambari
[2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid inhibits DNA binding to transcription factor Sp1.
Nucleosides, nucleotides & nucleic acids 2000;19(8):1219-29.
2000: Pier Giovanni Baraldi; LUISA-CARLOTA LÓPEZ-CARA; Italo Beria; Paolo Cozzi; Cristina Geroni; Nicola Mongelli; Nicoletta Bianchi; Carlo Mischiati; Roberto Gambari
Synthesis and antitumor activity of new benzoheterocyclic derivatives of distamycin A.
Journal of medicinal chemistry 2000;43(14):2675-84.
2000: Pier Giovanni Baraldi; LUISA-CARLOTA LÓPEZ-CARA; Adriano Duatti; Cristina Bolzati; Adriano Piffanelli; Nicoletta Bianchi; Carlo Mischiati; Roberto Gambari
Synthesis of hybrid distamycin-cysteine labeled with 99mTc: a model for a novel class of cancer imaging agents.
Bioorganic & medicinal chemistry letters 2000;10(12):1397-400.
2000: Katia Varani; Stefania Merighi; Stefania Gessi; Karl-Norbert Klotz; Edward Leung; Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Pier Andrea Borea
[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.
Molecular pharmacology 2000;57(5):968-75.
2000: Pier Giovanni Baraldi; LUISA-CARLOTA LÓPEZ-CARA; Mojgan Aghazadeh Tabrizi; Simonetta Falzoni; Francesco Di Virgilio
Synthesis of conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor.
Bioorganic & medicinal chemistry letters 2000;10(7):681-4.
2000: Stefano Manfredini; Pier Giovanni Baraldi; R Bazzanini; Elisa Durini; Silvia Vertuani; Alessandra Pani; Tiziana Marceddu; F Demontis; Laura Vargiu; Paolo La Colla
Pyrazole related nucleosides 5. Synthesis and biological activity of 2'-deoxy-2',3'-dideoxy- and acyclo-analogues of 4-iodo-1-beta-D-ribofuranosyl-3-carboxymethyl pyrazole (IPCAR).
Nucleosides, nucleotides & nucleic acids 2000;19(4):705-22.
2000: Pier Giovanni Baraldi; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Paolo Cozzi; Nicola Mongelli; Nicoletta Bianchi; Roberto Gambari
DNA sequence-recognizing properties of minor groove alkylating agents. Effects of the replacement of N-methylpyrrole by an N-methylimidazole on tallimustine and its own homologue.
Arzneimittel-Forschung 2000;50(3):309-15.
2000: Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Stefania Merighi; Katia Varani; Pier Andrea Borea; Giampiero Spalluto
A(3) adenosine receptor ligands: history and perspectives.
Medicinal research reviews 2000;20(2):103-28.
2000: Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Katia Varani; Stefania Merighi; Stefania Gessi; Pier Andrea Borea; Edward Leung; S L Hickey; Giampiero Spalluto
Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors.
Bioorganic & medicinal chemistry letters 2000;10(3):209-11.
1999: Pier Giovanni Baraldi; Gianfranco Balboni; Barbara Cacciari; Andrea Guiotto; Stefano Manfredini; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; David E Thurston; Philip W Howard; Nicoletta Bianchi; Cristina Rutigliano; Carlo Mischiati; Roberto Gambari
Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo[2,1-c][1, 4]benzodiazepine and minor-groove-binding oligopyrrole carriers.
Journal of medicinal chemistry 1999;42(25):5131-41.
1999: Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto
1H-pyrazolo[2,3-d][1,2,4]triazine-3,7-diones as a new class of human leukocyte elastase inhibitors.
Arzneimittel-Forschung 1999;49(12):997-1000.
1999: Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Karl-Norbert Klotz; E Leung; Katia Varani; Stefania Gessi; Stefania Merighi; Pier Andrea Borea
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists.
Journal of medicinal chemistry 1999;42(22):4473-8.
1999: Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; C W Boyce; Dale L Boger
Resolution of a CPzI precursor, synthesis and biological evaluation of (+) and (-)-N-Boc-CPzI: a further validation of the relationship between chemical solvolytic stability and cytotoxicity.
Bioorganic & medicinal chemistry letters 1999;9(21):3087-92.
1999: Stefano Manfredini; Pier Giovanni Baraldi; Elisa Durini; Silvia Vertuani; Jan Balzarini; Erik De Clercq; Anna Karlsson; V Buzzoni; L Thelander
5'-Phosphoramidates and 5'-diphosphates of 2'-O-allyl-beta-D-arabinofuranosyluracil, -cytosine, and -adenine: inhibition of ribonucleotide reductase.
Journal of medicinal chemistry 1999;42(17):3243-50.
1999: David E Thurston; D S Bose; Philip W Howard; Terence C Jenkins; A Leoni; Pier Giovanni Baraldi; Andrea Guiotto; Barbara Cacciari; Lloyd R Kelland; M P Foloppe; S Rault
Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines.
Journal of medicinal chemistry 1999;42(11):1951-64.
1999: Stefano Manfredini; Pier Giovanni Baraldi; Elisa Durini; Jan Balzarini; Erik De Clercq; Anna Karlsson; V Buzzoni; L Thelander
Synthesis, cytostatic activity and inhibition of ribonucleotide reductase by 5'-phosphoramidates and 5'-diphosphates, of 2'-O-allyl-arabinofuranosyl nucleosides.
Nucleosides & nucleotides 1999;18(4-5):1007-8.
1999: Pier Giovanni Baraldi; Gianfranco Balboni; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Paolo Cozzi; Cristina Geroni; Nicola Mongelli; Cristina Rutigliano; Nicoletta Bianchi; Roberto Gambari
PNU 157977: a new potent antitumour agent exhibiting low in vivo toxicity in mice injected with L1210 leukaemia cells.
Anti-cancer drug design 1999;14(1):71-6.
1999: Pier Giovanni Baraldi; Paolo Cozzi; Cristina Geroni; Nicola Mongelli; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto
Novel benzoyl nitrogen mustard derivatives of pyrazole analogues of distamycin A: synthesis and antileukemic activity.
Bioorganic & medicinal chemistry 1999;7(2):251-62.
1999: Pier Giovanni Baraldi; Barbara Cacciari; Andrea Guiotto; LUISA-CARLOTA LÓPEZ-CARA; Abdel N Zaid; Giampiero Spalluto
DNA minor-groove binders: results and design of new antitumor agents.
Farmaco (Società chimica italiana : 1989) 1999;54(1-2):15-25.
1998: Pier Giovanni Baraldi; Barbara Cacciari; Andrea Guiotto; A Leoni; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Nicola Mongelli; Philip W Howard; David E Thurston; Nicoletta Bianchi; Roberto Gambari
Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid.
Bioorganic & medicinal chemistry letters 1998;8(21):3019-24.
1998: Andrea Guiotto; Philip W Howard; Pier Giovanni Baraldi; David E Thurston
Synthesis of novel C7-aryl substituted pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) via pro-N10-Troc protection and Suzuki coupling.
Bioorganic & medicinal chemistry letters 1998;8(21):3017-8.
1998: Pier Giovanni Baraldi; Barbara Cacciari; Maria Josè Pineda de las Infantas; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Rosaria Volpini; Stefano Costanzi; Sauro Vittori; Gloria Cristalli; Neli Melman; K S Park; Xiao-Duo Ji; Kenneth Alan Jacobson
Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5'-N-ethyluronamide as A1 and A3 adenosine receptor agonists.
Journal of medicinal chemistry 1998;41(17):3174-85.
1998: Pier Giovanni Baraldi; Barbara Cacciari; Giampiero Spalluto; M Bergonzoni; S Dionisotti; Ennio Ongini; Katia Varani; Pier Andrea Borea
Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists.
Journal of medicinal chemistry 1998;41(12):2126-33.
1998: Pier Giovanni Baraldi; Barbara Cacciari; Andrea Guiotto; LUISA-CARLOTA LÓPEZ-CARA; Abdel N Zaid; Giampiero Spalluto
Heterocyclic analogs of DNA minor groove alkylating agents.
Current pharmaceutical design 1998;4(3):249-76.
1998: Stefano Manfredini; Pier Giovanni Baraldi; R Bazzanini; F Bortolotti; Silvia Vertuani; Noriyuki Ashida; H Machida
Enzymatic synthesis of 2'-O-acyl prodrugs of 1-(beta-D-arabinofuranosyl)-5(E)-(2-bromovinyl)uracil and of 2'-O-acyl-araU, -araC and -araA.
Antiviral chemistry & chemotherapy 1998;9(1):25-31.
1998: Katia Varani; Barbara Cacciari; Pier Giovanni Baraldi; S Dionisotti; Ennio Ongini; Pier Andrea Borea
Binding affinity of adenosine receptor agonists and antagonists at human cloned A3 adenosine receptors.
Life sciences 1998;63(5):PL 81-7.
1997: Pier Giovanni Baraldi; Barbara Cacciari; Andrea Guiotto; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Abdel N Zaid; L Capolongo; Paolo Cozzi; Cristina Geroni; Nicola Mongelli
Synthesis, solvolytic stability and cytotoxicity of a modified derivative of CPzI, a pyrazole analog of the alkylation subunit of the antitumor agent CC-1065: effect of the nitrogen substitution on the functional reactivity.
Farmaco (Società chimica italiana : 1989) 1997;52(12):717-23.
1997: Pier Giovanni Baraldi; Barbara Cacciari; Andrea Guiotto; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Abdel N Zaid; Paolo Cozzi; Cristina Geroni; Nicola Mongelli
Synthesis, cytotoxicity and antitumor activity of some new simplified pyrazole analogs of the antitumor agent CC-1065. Effect of an hydrophobic group on antitumor activity.
Farmaco (Società chimica italiana : 1989) 1997;52(12):711-6.
1997: Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Roberto Gambari; Nicoletta Bianchi; M Passadore; P Ambrosino; Nicola Mongelli; Paolo Cozzi; Cristina Geroni
Synthesis, cytotoxicity, antitumor activity and sequence selective binding of two pyrazole analogs structurally related to the antitumor agents U-71,184 and adozelesin.
Anti-cancer drug design 1997;12(7):555-76.
1997: Pier Giovanni Baraldi; Barbara Cacciari; Maria Josè Pineda de las Infantas; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Paolo Cozzi; Nicola Mongelli
Synthesis, chemical solvolytic stability and preliminary biological evaluation of (+/-)-N-Boc-CPzI: a pyrazole analog of the left-hand segment of the antitumor agent CC-1065.
Anti-cancer drug design 1997;12(1):67-74.
1996: Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Laura Garuti; Marinella Roberti; Alessandra Pani; G Perra; F Scintu; N Pinna; Chiara Musiu; Paolo La Colla
Synthesis, antiviral and antiproliferative activity of a new class of 5-(alkyl or arylthio)-6-vinyl uracils.
Anti-cancer drug design 1996;11(8):597-609.
1996: Pier Giovanni Baraldi; Barbara Cacciari; Alessandro Dalpiaz; S Dionisotti; C Zocchi; Maria Josè Pineda de las Infantas; Giampiero Spalluto; Katia Varani
1H-pyrazolo[4,3-d]pyrimidine-7(6H)-one and 5H-pyrazolo[4,3-d] 1,2,3-triazin-4(3H)-one derivatives. Synthesis and in vitro biological activity at adenosine A1 and A2a receptors.
Arzneimittel-Forschung 1996;46(4):365-8.
1996: C Zocchi; Ennio Ongini; S Ferrara; Pier Giovanni Baraldi; S Dionisotti
Binding of the radioligand [3H]-SCH 58261, a new non-xanthine A2A adenosine receptor antagonist, to rat striatal membranes.
British journal of pharmacology 1996;117(7):1381-6.
1996: Stefano Manfredini; R Bazzanini; Pier Giovanni Baraldi; M Bonora; M Marangoni; Daniele Simoni; Alessandra Pani; F Scintu; E Pinna; L Pisano; Paolo La Colla
Pyrazole-related nucleosides. 4. Synthesis and antitumor activity of some 1-tetrahydropyranyl-4-substituted pyrazoles.
Anti-cancer drug design 1996;11(3):193-204.
1996: Pier Giovanni Baraldi; Barbara Cacciari; Giampiero Spalluto; M J Pineda de las Infants; C Zocchi; S Ferrara; S Dionisotti; S FerraDDionisotti
1,2,3-Triazolo[5,4-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: a new class of A2A adenosine receptor antagonists.
Farmaco (Società chimica italiana : 1989) 1996;51(4):297-300.
1996: Pier Giovanni Baraldi; Barbara Cacciari; Giampiero Spalluto; M J Pineda de las Infantas y Villatoro; C Zocchi; S Dionisotti; Ennio Ongini
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives: potent and selective A(2A) adenosine antagonists.
Journal of medicinal chemistry 1996;39(5):1164-71.
1996: Pier Giovanni Baraldi; Barbara Cacciari; Giampiero Spalluto; Xiao-Duo Ji; ME Olah; G Stiles; S Dionisotti; C Zocchi; Ennio Ongini; Kenneth Alan Jacobson
Novel N6-(substituted-phenylcarbamoyl)adenosine-5'-uronamides as potent agonists for A3 adenosine receptors.
Journal of medicinal chemistry 1996;39(3):802-6.
1996: C Zocchi; Ennio Ongini; A Conti; Angela Monopoli; A Negretti; Pier Giovanni Baraldi; S Dionisotti
The non-xanthine heterocyclic compound SCH 58261 is a new potent and selective A2a adenosine receptor antagonist.
The Journal of pharmacology and experimental therapeutics 1996;276(2):398-404.
1995: Stefano Manfredini; Pier Giovanni Baraldi; R Bazzanini; M Marangoni; Daniele Simoni; Jan Balzarini; E De Clercq
Synthesis and cytotoxic activity of 6-vinyl- and 6-ethynyluridine and 8-vinyl-and 8-ethynyladenosine.
Journal of medicinal chemistry 1995;38(1):199-203.
1994: Pier Giovanni Baraldi; Alberto Leoni; Barbara Cacciari; Stefano Manfredini; Daniele Simoni; M Bergomi; Ernesto Menta; S Spinelli
Synthesis and antitumor activity of a new class of pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone analogues of pyrrolo[1,4][2,1-c]benzodiazepines.
Journal of medicinal chemistry 1994;37(25):4329-37.
1994: Stefano Manfredini; Pier Giovanni Baraldi; R Bazzanini; M Guarneri; Daniele Simoni; Jan Balzarini; E De Clercq
Geiparvarin analogues. 4. Synthesis and cytostatic activity of geiparvarin analogues bearing a carbamate moiety or a furocoumarin fragment on the alkenyl side chain.
Journal of medicinal chemistry 1994;37(15):2401-5.
1993: Laura Garuti; N Ghedini; Alberto Leoni; Pier Giovanni Baraldi; S Dionisotti
Design and synthesis of 3-(benzimidazol-2-yl)-propionic acids as thromboxane A2 receptor antagonists.
Farmaco (Società chimica italiana : 1989) 1993;48(11):1531-46.
1993: Pier Giovanni Baraldi; Laura Garuti; Alberto Leoni; Barbara Cacciari; Roberta Budriesi; Alberto Chiarini
Synthesis and cardiodepressant activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-(pentatomic-heteroaryl)-3,5-pyridine-dicarbo xylates. 2.
Drug design and discovery 1993;10(4):319-29.
1992: Pier Giovanni Baraldi; Stefano Manfredini; Daniele Simoni; M A Tabrizi; Jan Balzarini; E De Clercq
Geiparvarin analogues. 3. Synthesis and cytostatic activity of 3(2H)-furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain.
Journal of medicinal chemistry 1992;35(10):1877-82.
1992: Stefano Manfredini; R Bazzanini; Pier Giovanni Baraldi; M Guarneri; Daniele Simoni; Maria Elena Marongiu; Alessandra Pani; Enzo Tramontano; Paolo La Colla
Pyrazole-related nucleosides. Synthesis and antiviral/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides.
Journal of medicinal chemistry 1992;35(5):917-24.
1992: Daniele Simoni; Stefano Manfredini; M A Tabrizi; R Bazzanini; Pier Giovanni Baraldi; R Ferroni; F Traniello; Claudio Nastruzzi; Giordana Feriotto; R Gambari
New isoxazole derivatives of retinoids: synthesis and activity on growth and differentiation of tumor cells.
Drug design and discovery 1992;8(3):165-77.
1991: Daniele Simoni; Stefano Manfredini; M A Tabrizi; R Bazzanini; Pier Giovanni Baraldi; Jan Balzarini; E De Clercq
Geiparvarin analogues. 2. Synthesis and cytostatic activity of 5-(4-arylbutadienyl)-3(2H)-furanones and of N-substituted 3-(4-oxo-2-furanyl)-2-buten-2-yl carbamates.
Journal of medicinal chemistry 1991;34(11):3172-6.
1991: Pier Giovanni Baraldi; Barbara Cacciari; Alberto Leoni; Maurizio Recanatini; Marinella Roberti; M Rossi; Stefano Manfredini; V Periotto; Daniele Simoni
Synthesis, antibacterial activity and structure-activity relationships of N-substituted 4-diazo-pyrazole-5-carboxamides. 2.
Farmaco (Società chimica italiana : 1989) 1991;46(11):1337-50.
1990: L Beani; C Bianchi; Pier Giovanni Baraldi; Stefano Manfredini; G P Pollini
Protection by pyroglutamic acid and some of its newly synthesized derivatives against glutamate-induced seizures in mice.
Arzneimittel-Forschung 1990;40(11):1187-91.
1989: Pier Giovanni Baraldi; Patrizia Brigidi; A Casolari; Stefano Manfredini; V Periotto; Maurizio Recanatini; Marinella Roberti; M Rossi
Synthesis, antibacterial activity and structure-activity relationships of N-substituted 3-methyl-4-diazo-5-pyrazolecarboxamides.
Arzneimittel-Forschung 1989;39(11):1406-10.
1989: Claudio Nastruzzi; Daniele Simoni; Stefano Manfredini; R Barbieri; Giordana Feriotto; Pier Giovanni Baraldi; D Spandidos; M Guarneri; R Gambari
New synthetic retinoids: effects on proliferation and differentiation.
Anticancer research 1989;9(5):1377-83.
1989: Pier Giovanni Baraldi; M Guarneri; Stefano Manfredini; Daniele Simoni; V Zanirato
[Synthesis and evaluation of the antifungal activity of a new series of N-acylureas].
Farmaco (Società chimica italiana : 1989) 1989;44(4):391-8.
1989: Pier Giovanni Baraldi; M Guarneri; Stefano Manfredini; Daniele Simoni; Jan Balzarini; E De Clercq
Synthesis and cytostatic activity of geiparvarin analogues.
Journal of medicinal chemistry 1989;32(2):284-8.
1988: Pier Giovanni Baraldi; A Casolari; Stefano Manfredini; V Periotto; V Zanirato; C Florio; V Traversa; G M Bertelli; P A Borea
Synthesis of 1H-pyrazolo[4,3-d]pyrimidine-7(6H)-ones and pyrazolo-5-carboxamides and interaction with benzodiazepine and adenosine A1 receptors in rat cerebral cortex.
Arzneimittel-Forschung 1988;38(9):1262-5.
1985: Pier Giovanni Baraldi; Stefano Manfredini; V Periotto; Daniele Simoni; M Guarneri; P A Borea
Synthesis and interaction of 5-(substituted-phenyl)-3-methyl-6,7-dihydropyrazolo[4,3-e] [1,4]diazepin-8(7H)-ones with benzodiazepine receptors in rat cerebral cortex.
Journal of medicinal chemistry 1985;28(5):683-5.
1984: Pier Giovanni Baraldi; Daniele Simoni; V Periotto; Stefano Manfredini; M Guarneri; Roberto Manservigi; Enzo Cassai; V Bertolasi
Pyrazolo[4,3-d]pyrimidine nucleosides. Synthesis and antiviral activity of 1-beta-D-ribofuranosyl-3-methyl-6-substituted-7H-pyrazolo[4,3-d]pyr imi din-7-ones.
Journal of medicinal chemistry 1984;27(8):986-90.
1983: Pier Giovanni Baraldi; Daniele Simoni; A Casolari; Stefano Manfredini
Azaprostaglandins. Synthesis and antiulcer activity of 11-deoxy-8-azaprostaglandin analogues.
Il Farmaco; edizione scientifica 1983;38(7):498-507.
1983: Pier Giovanni Baraldi; C B Vicentini; Daniele Simoni; E Menziani
[Synthesis of pyrazole and pyrazolo [4,3-d] pyrimidinone derivatives. II].
Il Farmaco; edizione scientifica 1983;38(7):508-13.
1983: Pier Giovanni Baraldi; C B Vicentini; Daniele Simoni; M Guarneri
[Synthesis of pyrazole derivatives and pyrazolo[4,3-d]pyrimidines. I].
Il Farmaco; edizione scientifica 1983;38(6):370-5.
1983: Pier Andrea Borea; A Bonora; Pier Giovanni Baraldi; Daniele Simoni
Brain receptor binding of analogues of gamma-aminobutyric acid (GABA).
Il Farmaco; edizione scientifica 1983;38(6):411-7.
1981: A Barco; S Benetti; G P Pollini; Pier Giovanni Baraldi; M Guarneri; C Gandolfi; R Ceserani; D Longiave
Azaprostaglandin analogues. Synthesis and biological properties of 11-azaprostaglandin derivatives.
Journal of medicinal chemistry 1981;24(5):625-8.
1980: Pier Giovanni Baraldi; F Dalla Vecchia; M Guarneri; C B Vicentini; R Ceserani
[Synthesis of compounds with antisecretory activity].
Il Farmaco; edizione scientifica 1980;35(8):698-705.
1980: C B Vicentini; A C Veronese; P Giori; Pier Giovanni Baraldi; M Guarneri
Carboxyl activation in peptide synthesis using 4-oximino-pyrazol-5-ones.
International journal of peptide and protein research 1980;16(1):48-54.