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Pier Giovanni Baraldi

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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MacMillan Karen S; Lajiness James P; Cara Carlota Lopez; Romagnoli Romeo; Robertson William M; Hwang Inkyu; Baraldi Pier Giovanni; Boger Dale L
Synthesis and evaluation of a thio analogue of duocarmycin SA.
Andrè E; Gatti R; Trevisani M; Preti D; Baraldi P G; Patacchini R; Geppetti P
Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents.
Merighi Stefania; Simioni Carolina; Gessi Stefania; Varani Katia; Mirandola Prisco; Tabrizi Mojgan Aghazadeh; Baraldi Pier Giovanni; Borea Pier Andrea
A(2B) and A(3) adenosine receptors modulate vascular endothelial growth factor and interleukin-8 expression in human melanoma cells treated with etoposide and doxorubicin.

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All Publications

2009: MacMillan Karen S; Lajiness James P; Cara Carlota Lopez; Romagnoli Romeo; Robertson William M; Hwang Inkyu; Baraldi Pier Giovanni; Boger Dale L
Synthesis and evaluation of a thio analogue of duocarmycin SA.
Bioorganic & medicinal chemistry letters 2009;19(24):6962-5.
2009: Andrè E; Gatti R; Trevisani M; Preti D; Baraldi P G; Patacchini R; Geppetti P
Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents.
British journal of pharmacology 2009;158(6):1621-8.
2009: Merighi Stefania; Simioni Carolina; Gessi Stefania; Varani Katia; Mirandola Prisco; Tabrizi Mojgan Aghazadeh; Baraldi Pier Giovanni; Borea Pier Andrea
A(2B) and A(3) adenosine receptors modulate vascular endothelial growth factor and interleukin-8 expression in human melanoma cells treated with etoposide and doxorubicin.
Neoplasia (New York, N.Y.) 2009;11(10):1064-73.
2009: Romagnoli Romeo; Baraldi Pier Giovanni; Carrion Maria Dora; Cara Carlota Lopez; Cruz-Lopez Olga; Tolomeo Manlio; Grimaudo Stefania; Di Cristina Antonietta; Pipitone Maria Rosaria; Balzarini Jan; Zonta Nicola; Brancale Andrea; Hamel Ernest
Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization.
Bioorganic & medicinal chemistry 2009;17(19):6862-71.
2009: Romagnoli Romeo; Baraldi Pier Giovanni; Cruz-Lopez Olga; Preti Delia; Bermejo Jaime; Estévez Francisco
alpha-Bromoacrylamido N-substituted isatin derivatives as potent inducers of apoptosis in human myeloid leukemia cells.
ChemMedChem 2009;4(10):1668-76.
2009: Romagnoli Romeo; Baraldi Pier Giovanni; Carrion Maria Dora; Cruz-Lopez Olga; Cara Carlota Lopez; Basso Giuseppe; Viola Giampietro; Khedr Mohammed; Balzarini Jan; Mahboobi Siavosh; Sellmer Andreas; Brancale Andrea; Hamel Ernest
2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization.
Journal of medicinal chemistry 2009;52(17):5551-5.
2009: Paeshuyse Jan; Letellier Carine; Froeyen Matheus; Dutartre Hélène; Vrancken Robert; Canard Bruno; De Clercq Erik; Gueiffier Alain; Teulade Jean-Claude; Herdewijn Piet; Puerstinger Gerhard; Koenen Frank; Kerkhofs Pierre; Baraldi Pier Giovanni; Neyts Johan
A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.
Antiviral research 2009;82(3):141-7.
2009: Romagnoli Romeo; Baraldi Pier Giovanni; Carrion Maria Dora; Cruz-Lopez Olga; Cara Carlota Lopez; Balzarini Jan; Hamel Ernest; Canella Alessandro; Fabbri Enrica; Gambari Roberto; Basso Giuseppe; Viola Giampietro
Hybrid alpha-bromoacryloylamido chalcones. Design, synthesis and biological evaluation.
Bioorganic & medicinal chemistry letters 2009;19(7):2022-8.
2009: Baraldi Pier Giovanni; Tabrizi Mojgan Aghazadeh; Fruttarolo Francesca; Romagnoli Romeo; Preti Delia
Recent improvements in the development of A(2B) adenosine receptor agonists.
Purinergic signalling 2009;5(1):3-19.
2009: Romagnoli Romeo; Baraldi Pier Giovanni; Cruz-Lopez Olga; Lopez-Cara Carlota; Preti Delia
alpha-halogenoacrylic derivatives of antitumor agents.
Mini reviews in medicinal chemistry 2009;9(1):81-94.
2009: Jacobson Kenneth A; Klutz Athena M; Tosh Dilip K; Ivanov Andrei A; Preti Delia; Baraldi Pier Giovanni
Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering.
Handbook of experimental pharmacology 2009;(193):123-59.
2009: Kalla Rao V; Zablocki Jeff; Tabrizi Mojgan Aghazadeh; Baraldi Pier Giovanni
Recent developments in A2B adenosine receptor ligands.
Handbook of experimental pharmacology 2009;(193):99-122.
2008: Baraldi Pier Giovanni; Preti Delia; Tabrizi Mojgan Aghazadeh; Romagnoli Romeo; Saponaro Giulia; Baraldi Stefania; Botta Maurizio; Bernardini Cesare; Tafi Andrea; Tuccinardi Tiziano; Martinelli Adriano; Varani Katia; Borea Pier Andrea
Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2008;16(24):10281-94.
2008: Baraldi Pier Giovanni; Tabrizi Mojgan Aghazadeh; Fruttarolo Francesca; Romagnoli Romeo; Preti Delia
Recent improvements in the development of A(2B) adenosine receptor agonists.
Purinergic signalling 2008;4(4):287-303.
2008: Romagnoli Romeo; Baraldi Pier Giovanni; Sarkar Taradas; Cara Carlota Lopez; Lopez Olga Cruz; Carrion Maria Dora; Preti Delia; Tolomeo Manlio; Balzarini Jan; Hamel Ernest
Synthesis and biological evaluation of 2-aroyl-4-phenyl-5-hydroxybenzofurans as a new class of antitubulin agents.
Medicinal chemistry (Shariqah (United Arab Emirates)) 2008;4(6):558-64.
2008: Romagnoli Romeo; Baraldi Pier Giovanni; Sarkar Taradas; Carrion Maria Dora; Cruz-Lopez Olga; Lopez Cara Carlota; Tolomeo Manlio; Grimaudo Stefania; Di Cristina Antonietta; Pipitone Maria Rosaria; Balzarini Jan; Gambari Roberto; Ilaria Lampronti; Saletti Roberto; Brancale Andrea; Hamel Ernest
Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization.
Bioorganic & medicinal chemistry 2008;16(18):8419-26.
2008: Romagnoli Romeo; Baraldi Pier Giovanni; Carrion Maria Dora; Cara Carlota Lopez; Cruz-Lopez Olga; Iaconinoto Maria Antonietta; Preti Delia; Shryock John C; Moorman Allan R; Vincenzi Fabrizio; Varani Katia; Andrea Borea Pier
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor.
Journal of medicinal chemistry 2008;51(18):5875-9.
2008: Romagnoli Romeo; Baraldi Pier Giovanni; Carrion Maria Dora; Cruz-Lopez Olga; Cara Carlota Lopez; Tolomeo Manlio; Grimaudo Stefania; Di Cristina Antonietta; Pipitone Maria Rosa; Balzarini Jan; Kandil Sahar; Brancale Andrea; Sarkar Taradas; Hamel Ernest
Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerization.
Bioorganic & medicinal chemistry letters 2008;18(18):5041-5.
2008: Andrè Eunice; Campi Barbara; Materazzi Serena; Trevisani Marcello; Amadesi Silvia; Massi Daniela; Creminon Christophe; Vaksman Natalya; Nassini Romina; Civelli Maurizio; Baraldi Pier Giovanni; Poole Daniel P; Bunnett Nigel W; Geppetti Pierangelo; Patacchini Riccardo
Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents.
The Journal of clinical investigation 2008;118(7):2574-82.
2008: Romagnoli Romeo; Baraldi Pier Giovanni; Carrion Maria Dora; Cara Carlota Lopez; Cruz-Lopez Olga; Preti Delia; Tolomeo Manlio; Grimaudo Stefania; Di Cristina Antonella; Zonta Nicola; Balzarini Jan; Brancale Andrea; Sarkar Taradas; Hamel Ernest
Design, synthesis, and biological evaluation of thiophene analogues of chalcones.
Bioorganic & medicinal chemistry 2008;16(10):5367-76.
2008: Romagnoli Romeo; Baraldi Pier Giovanni; Cruz-Lopez Olga; Lopez-Cara Carlota; Preti Delia; Borea Pier Andrea; Gessi Stefania
The P2X7 receptor as a therapeutic target.
Expert opinion on therapeutic targets 2008;12(5):647-61.
2008: Romagnoli Romeo; Baraldi Pier Giovanni; Sarkar Taradas; Carrion Maria Dora; Cara Carlota Lopez; Cruz-Lopez Olga; Preti Delia; Tabrizi Mojgan Aghazadeh; Tolomeo Manlio; Grimaudo Stefania; Di Cristina Antonella; Zonta Nicola; Balzarini Jan; Brancale Andrea; Hsieh Hsing-Pang; Hamel Ernest
Synthesis and biological evaluation of 1-methyl-2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors.
Journal of medicinal chemistry 2008;51(5):1464-8.
2008: Tabrizi Mojgan Aghazadeh; Baraldi Pier Giovanni; Preti Delia; Romagnoli Romeo; Saponaro Giulia; Baraldi Stefania; Moorman Allan R; Zaid Abdel Naser; Varani Katia; Borea Pier Andrea
1,3-Dipropyl-8-(1-phenylacetamide-1H-pyrazol-3-yl)-xanthine derivatives as highly potent and selective human A(2B) adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2008;16(5):2419-30.
2008: Baraldi Pier Giovanni; Tabrizi Mojgan Aghazadeh; Gessi Stefania; Borea Pier Andrea
Adenosine receptor antagonists: translating medicinal chemistry and pharmacology into clinical utility.
Chemical reviews 2008;108(1):238-63.
2007: Romagnoli Romeo; Baraldi Pier Giovanni; Remusat Vincent; Carrion Maria Dora; Cara Carlota Lopez; Cruz-Lopez Olga; Preti Delia; Fruttarolo Francesca; Tabrizi Mojgan Aghazadeh; Balzarini Jan; Hamel Ernest
Synthesis and biological evaluation of 2-amino-3-(3', 4', 5'-trimethoxy-phenylsulfonyl)-5-aryl thiophenes as a new class of antitubulin agents.
Medicinal chemistry (Shariqah (United Arab Emirates)) 2007;3(6):507-12.
2007: Tichenor Mark S; MacMillan Karen S; Stover James S; Wolkenberg Scott E; Pavani Maria G; Zanella Lorenzo; Zaid Abdel N; Spalluto Gianpiero; Rayl Thomas J; Hwang Inkyu; Baraldi Pier Giovanni; Boger Dale L
Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.
Journal of the American Chemical Society 2007;129(45):14092-9.
2007: Merighi Stefania; Benini Annalisa; Mirandola Prisco; Gessi Stefania; Varani Katia; Simioni Carolina; Leung Edward; Maclennan Stephen; Baraldi Pier Giovanni; Borea Pier Andrea
Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells.
Molecular pharmacology 2007;72(2):395-406.
2007: Romagnoli Romeo; Baraldi Pier Giovanni; Carrion Maria Dora; Cara Carlota Lopez; Preti Delia; Cruz-Lopez Olga; Tabrizi Mojgan Aghazadeh; Moorman Allan R; Gessi Stefania; Fogli Eleonora; Sacchetto Valeria; Borea Pier Andrea
From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor.
Journal of medicinal chemistry 2007;50(15):3706-15.
2007: Merighi Stefania; Benini Annalisa; Mirandola Prisco; Gessi Stefania; Varani Katia; Leung Edward; Maclennan Stephen; Baraldi Pier Giovanni; Borea Pier Andrea
Hypoxia inhibits paclitaxel-induced apoptosis through adenosine-mediated phosphorylation of bad in glioblastoma cells.
Molecular pharmacology 2007;72(1):162-72.
2007: Baraldi Pier Giovanni; Iaconinoto Maria Antonietta; Moorman Allan R; Carrion Maria Dora; Cara Carlota Lopez; Preti Delia; López Olga Cruz; Fruttarolo Francesca; Tabrizi Mojgan Aghazade; Romagnoli Romeo
Allosteric enhancers for A1 adenosine receptor.
Mini reviews in medicinal chemistry 2007;7(6):559-69.
2007: Romagnoli Romeo; Baraldi Pier Giovanni; Carrion Maria Dora; Lopez Cara Carlota; Preti Delia; Fruttarolo Francesca; Pavani Maria Giovanna; Tabrizi Mojgan Aghazadeh; Tolomeo Manlio; Grimaudo Stefania; Di Cristina Antonella; Balzarini Jan; Hadfield John A; Brancale Andrea; Hamel Ernest
Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization.
Journal of medicinal chemistry 2007;50(9):2273-7.
2007: Romagnoli Romeo; Baraldi Pier Giovanni; Carrion Maria Dora; Cruz-Lopez Olga; Preti Delia; Tabrizi Mojgan Aghazadeh; Fruttarolo Francesca; Heilmann Jörg; Bermejo Jaime; Estévez Francisco
Hybrid molecules containing benzo[4,5]imidazo[1,2-d][1,2,4]thiadiazole and alpha-bromoacryloyl moieties as potent apoptosis inducers on human myeloid leukaemia cells.
Bioorganic & medicinal chemistry letters 2007;17(10):2844-8.
2007: Baraldi Pier Giovanni; Preti Delia; Tabrizi Mojgan Aghazadeh; Fruttarolo Francesca; Saponaro Giulia; Baraldi Stefania; Romagnoli Romeo; Moorman Allan R; Gessi Stefania; Varani Katia; Borea Pier Andrea
N(6)-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5'-N-ethylcarboxamido-adenosines: the first example of adenosine-related structures with potent agonist activity at the human A(2B) adenosine receptor.
Bioorganic & medicinal chemistry 2007;15(7):2514-27.
2007: Baraldi Pier Giovanni; Preti Delia; Tabrizi Mojgan Aghazadeh; Fruttarolo Francesca; Romagnoli Romeo; Carrion Maria Dora; Cara Luisa Carlota Lopez; Moorman Allan R; Varani Katia; Borea Pier Andrea
Synthesis and biological evaluation of novel 1-deoxy-1-[6-[((hetero)arylcarbonyl)hydrazino]- 9H-purin-9-yl]-N-ethyl-beta-D-ribofuranuronamide derivatives as useful templates for the development of A2B adenosine receptor agonists.
Journal of medicinal chemistry 2007;50(2):374-80.
2007: Baraldi Pier Giovanni; Preti Delia; Fruttarolo Francesca; Tabrizi Mojgan Aghazadeh; Romagnoli Romeo
Hybrid molecules between distamycin A and active moieties of antitumor agents.
Bioorganic & medicinal chemistry 2007;15(1):17-35.
2006: Merighi Stefania; Benini Annalisa; Mirandola Prisco; Gessi Stefania; Varani Katia; Leung Edward; Maclennan Stephen; Baraldi Pier Giovanni; Borea Pier Andrea
Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A(3) adenosine receptor.
Purinergic signalling 2006;2(4):627-32.
2006: Gessi Stefania; Varani Katia; Merighi Stefania; Leung Edward; Mac Lennan Stephen; Baraldi Pier Giovanni; Borea Pier Andrea
Novel selective antagonist radioligands for the pharmacological study of A(2B) adenosine receptors.
Purinergic signalling 2006;2(4):583-8.
2006: Romagnoli Romeo; Baraldi Pier Giovanni; Moorman Allan R; Iaconinoto Maria Antonietta; Carrion Maria Dora; Cara Carlota Lopez; Tabrizi Mojgan Aghazadeh; Preti Delia; Fruttarolo Francesca; Baker Stephen P; Varani Katia; Borea Pier Andrea
Microwave-assisted synthesis of thieno[2,3-c]pyridine derivatives as a new series of allosteric enhancers at the adenosine A(1) receptor.
Bioorganic & medicinal chemistry letters 2006;16(21):5530-3.
2006: Romagnoli Romeo; Baraldi Pier Giovanni; Remusat Vincent; Carrion Maria Dora; Cara Carlota Lopez; Preti Delia; Fruttarolo Francesca; Pavani Maria Giovanna; Tabrizi Mojgan Aghazadeh; Tolomeo Manlio; Grimaudo Stefania; Balzarini Jan; Jordan Mary Ann; Hamel Ernest
Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors.
Journal of medicinal chemistry 2006;49(21):6425-8.
2006: Tafi Andrea; Bernardini Cesare; Botta Maurizio; Corelli Federico; Andreini Matteo; Martinelli Adriano; Ortore Gabriella; Baraldi Pier Giovanni; Fruttarolo Francesca; Borea Pier Andrea; Tuccinardi Tiziano
Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models.
Journal of medicinal chemistry 2006;49(14):4085-97.
2006: Romagnoli Romeo; Baraldi Pier Giovanni; Pavani Maria Giovanna; Tabrizi Mojgan Aghazadeh; Preti Delia; Fruttarolo Francesca; Piccagli Laura; Jung M Katherine; Hamel Ernest; Borgatti Monica; Gambari Roberto
Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents.
Journal of medicinal chemistry 2006;49(13):3906-15.
2006: Pastorin Giorgia; Da Ros Tatiana; Bolcato Chiara; Montopoli Christian; Moro Stefano; Cacciari Barbara; Baraldi Pier Giovanni; Varani Katia; Borea Pier Andrea; Spalluto Giampiero
Synthesis and biological studies of a new series of 5-heteroarylcarbamoylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists. Influence of the heteroaryl substituent on binding affinity and molecular modeling investigations.
Journal of medicinal chemistry 2006;49(5):1720-9.
2006: Baraldi Pier Giovanni; Pavani Maria Giovanna; Leung Edward; Moorman Allan R; Varani Katia; Vincenzi Fabrizio; Borea Pier Andrea; Romagnoli Romeo
Synthesis and biological characterization of [3H] (2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(4-chlorophenyl)-methanone, the first radiolabelled adenosine A1 allosteric enhancer.
Bioorganic & medicinal chemistry letters 2006;16(5):1402-4.
2006: Melani Alessia; Gianfriddo Marco; Vannucchi Maria Giuliana; Cipriani Sara; Baraldi Pier Giovanni; Giovannini Maria Grazia; Pedata Felicita
The selective A2A receptor antagonist SCH 58261 protects from neurological deficit, brain damage and activation of p38 MAPK in rat focal cerebral ischemia.
Brain research 2006;1073-1074():470-80.
2006: Baraldi Pier Giovanni; Romagnoli Romeo; Preti Delia; Fruttarolo Francesca; Carrion Maria Dora; Tabrizi Mojgan Aghazadeh
Ligands for A2B adenosine receptor subtype.
Current medicinal chemistry 2006;13(28):3467-82.
2005: Romagnoli Romeo; Baraldi Pier Giovanni; Tabrizi Mojgan Aghazadeh; Bermejo Jaime; Estévez Francisco; Borgatti Monica; Gambari Roberto
Design, synthesis, and biological evaluation of hybrid molecules containing alpha-methylene-gamma-butyrolactones and alpha-bromoacryloyl moieties.
Journal of medicinal chemistry 2005;48(24):7906-10.
2005: Penolazzi Letizia; Bianchini Ercolina; Lambertini Elisabetta; Baraldi Pier Giovanni; Romagnoli Romeo; Piva Roberta; Gambari Roberto
N-Arylpiperazine modified analogues of the P2X7 receptor KN-62 antagonist are potent inducers of apoptosis of human primary osteoclasts.
Journal of biomedical science 2005;12(6):1013-20.
2005: Ivanov Andrei A; Baskin Igor I; Palyulin Vladimir A; Piccagli Laura; Baraldi Pier G; Zefirov Nikolai S
Molecular modeling and molecular dynamics simulation of the human A2B adenosine receptor. The study of the possible binding modes of the A2B receptor antagonists.
Journal of medicinal chemistry 2005;48(22):6813-20.
2005: Varani Katia; Gessi Stefania; Merighi Stefania; Vincenzi Fabrizio; Cattabriga Elena; Benini Annalisa; Klotz Karl-Norbert; Baraldi Pier Giovanni; Tabrizi Mojgan Aghazadeh; Lennan Stephen Mac; Leung Edward; Borea Pier Andrea
Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors.
Biochemical pharmacology 2005;70(11):1601-12.
2005: Romagnoli Romeo; Baraldi Pier Giovanni; Iaconinoto Maria Antonietta; Carrion Maria Dora; Tabrizi Mojgan Aghazadeh; Gambari Roberto; Borgatti Monica; Heilmann Jörg
Synthesis and biological activity of alpha-bromoacryloyl lexitropsin conjugates.
European journal of medicinal chemistry 2005;40(11):1123-8.
2005: Merighi Stefania; Benini Annalisa; Mirandola Prisco; Gessi Stefania; Varani Katia; Leung Edward; MacLennan Stephen; Baraldi Pier Giovanni; Borea Pier Andrea
A3 adenosine receptors modulate hypoxia-inducible factor-1alpha expression in human A375 melanoma cells.
Neoplasia (New York, N.Y.) 2005;7(10):894-903.
2005: Romagnoli Romeo; Baraldi Pier Giovanni; Jung M Katherine; Iaconinoto Maria Antonietta; Carrion Maria Dora; Remusat Vincent; Preti Delia; Tabrizi Mojgan Aghazadeh; Francesca Fruttarolo; De Clercq Erik; Balzarini Jan; Hamel Ernest
Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles.
Bioorganic & medicinal chemistry letters 2005;15(18):4048-52.
2005: Baraldi Pier Giovanni; Tabrizi Mojgan Aghazadeh; Preti Delia; Bovero Andrea; Fruttarolo Francesca; Romagnoli Romeo; Zaid Naser Abdel; Moorman Allan R; Varani Katia; Borea Pier Andrea
New 2-arylpyrazolo[4,3-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2005;48(15):5001-8.
2005: Baraldi Pier Giovanni; Preti Delia; Tabrizi Mojgan Aghazadeh; Fruttarolo Francesca; Romagnoli Romeo; Zaid Naser Abdel; Moorman Allan R; Merighi Stefania; Varani Katia; Borea Pier Andrea
New pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2005;48(14):4697-701.
2005: Gessi Stefania; Varani Katia; Merighi Stefania; Cattabriga Elena; Pancaldi Cecilia; Szabadkai Youri; Rizzuto Rosario; Klotz Karl-Norbert; Leung Edward; Mac Lennan Stephen; Baraldi Pier Giovanni; Borea Pier Andrea
Expression, pharmacological profile, and functional coupling of A2B receptors in a recombinant system and in peripheral blood cells using a novel selective antagonist radioligand, [3H]MRE 2029-F20.
Molecular pharmacology 2005;67(6):2137-47.
2005: Baraldi Pier Giovanni; Romagnoli Romeo; Tabrizi Mojgan Aghazadeh; Bovero Andrea; Preti Delia; Fruttarolo Francesca; Moorman Allan R; Borea Pier Andrea
New heterocyclic ligands for the adenosine receptors P1 and for the ATP receptors P2.
Farmaco (Società chimica italiana : 1989) 2005;60(3):185-202.
2005: Di Virgilio Francesco; Baricordi O Roberto; Romagnoli Romeo; Baraldi Pier Giovanni
Leukocyte P2 receptors: a novel target for anti-inflammatory and anti-tumor therapy.
Current drug targets. Cardiovascular & haematological disorders 2005;5(1):85-99.
2005: Moro Stefano; Braiuca Paolo; Deflorian Francesca; Ferrari Cristina; Pastorin Giorgia; Cacciari Barbara; Baraldi Pier Giovanni; Varani Katia; Borea Pier Andrea; Spalluto Giampiero
Combined target-based and ligand-based drug design approach as a tool to define a novel 3D-pharmacophore model of human A3 adenosine receptor antagonists: pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as a key study.
Journal of medicinal chemistry 2005;48(1):152-62.
2005: Baraldi Pier Giovanni; Tabrizi Mojgan Aghazadeh; Romagnoli Romeo; Fruttarolo Francesca; Merighi Stefania; Varani Katia; Gessi Stefania; Borea Pier Andrea
Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine ligands, new tools to characterize A3 adenosine receptors in human tumor cell lines.
Current medicinal chemistry 2005;12(11):1319-29.
2004: Romagnoli Romeo; Baraldi Pier Giovanni; Pavani Maria Giovanna; Tabrizi Mojgan Aghazadeh; Moorman Allan R; Di Virgilio Francesco; Cattabriga Elena; Pancaldi Cecilia; Gessi Stefania; Borea Pier Andrea
Synthesis, radiolabeling, and preliminary biological evaluation of [3H]-1-[(S)-N,O-bis-(isoquinolinesulfonyl)-N-methyl-tyrosyl]-4-(o-tolyl)-piperazine, a potent antagonist radioligand for the P2X7 receptor.
Bioorganic & medicinal chemistry letters 2004;14(22):5709-12.
2004: Baraldi Pier Giovanni; Fruttarolo Francesca; Tabrizi Mojgan Aghazadeh; Romagnoli Romeo; Preti Delia; Bovero Andrea; Pineda de Las Infantas Maria Josè; Moorman Allan; Varani Katia; Borea Pier Andrea
Synthesis and biological evaluation of novel N6-[4-(substituted)sulfonamidophenylcarbamoyl]adenosine-5'-uronamides as A3 adenosine receptor agonists.
Journal of medicinal chemistry 2004;47(22):5535-40.
2004: Baraldi Pier Giovanni; Pavani Maria Giovanna; Shryock John C; Moorman Allan R; Iannotta Valeria; Borea Pier Andrea; Romagnoli Romeo
Synthesis of 2-amino-3-heteroaroylthiophenes and evaluation of their activity as potential allosteric enhancers at the human A1 receptor.
European journal of medicinal chemistry 2004;39(10):855-65.
2004: Baraldi Pier Giovanni; Beria Italo; Cozzi Paolo; Geroni Cristina; Espinosa Antonio; Gallo Miguel A; Entrena Antonio; Bingham John P; Hartley John A; Romagnoli Romeo
Cinnamoyl nitrogen mustard derivatives of pyrazole analogues of tallimustine modified at the amidino moiety: design, synthesis, molecular modeling and antitumor activity studies.
Bioorganic & medicinal chemistry 2004;12(14):3911-21.
2004: Baraldi Pier Giovanni; Tabrizi Mojgan Aghazadeh; Preti Delia; Bovero Andrea; Fruttarolo Francesca; Romagnoli Romeo; Moorman Allan R; Gessi Stefania; Merighi Stefania; Varani Katia; Borea Pier Andrea
[3H]-MRE 2029-F20, a selective antagonist radioligand for the human A2B adenosine receptors.
Bioorganic & medicinal chemistry letters 2004;14(13):3607-10.
2004: Baraldi Pier Giovanni; Bovero Andrea; Fruttarolo Francesca; Preti Delia; Tabrizi Mojgan Aghazadeh; Pavani Maria Giovanna; Romagnoli Romeo
DNA minor groove binders as potential antitumor and antimicrobial agents.
Medicinal research reviews 2004;24(4):475-528.
2004: Baraldi Pier Giovanni; Del Carmen Nunez Maria; Tabrizi Mojgan Aghazadeh; De Clercq Erik; Balzarini Jan; Bermejo Jaime; Estévez Francisco; Romagnoli Romeo
Design, synthesis, and biological evaluation of hybrid molecules containing alpha-methylene-gamma-butyrolactones and polypyrrole minor groove binders.
Journal of medicinal chemistry 2004;47(11):2877-86.
2004: Beria Italo; Baraldi Pier Giovanni; Cozzi Paolo; Caldarelli Marina; Geroni Cristina; Marchini Sergio; Mongelli Nicola; Romagnoli Romeo
Cytotoxic alpha-halogenoacrylic derivatives of distamycin A and congeners.
Journal of medicinal chemistry 2004;47(10):2611-23.
2004: Baraldi Pier Giovanni; Tabrizi Mojgan Aghazadeh; Preti Delia; Bovero Andrea; Romagnoli Romeo; Fruttarolo Francesca; Zaid Naser Abdel; Moorman Allan R; Varani Katia; Gessi Stefania; Merighi Stefania; Borea Pier Andrea
Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists.
Journal of medicinal chemistry 2004;47(6):1434-47.
2004: Mischiati Carlo; Finotti Alessia; Sereni Alessia; Boschetti Sindi; Baraldi Pier Giovanni; Romagnoli Romeo; Feriotto Giordana; Jeang Kuan-Teh; Bianchi Nicoletta; Borgatti Monica; Gambari Roberto
Binding of hybrid molecules containing pyrrolo [2,1-c][1,4]benzodiazepine (PBD) and oligopyrrole carriers to the human immunodeficiency type 1 virus TAR-RNA.
Biochemical pharmacology 2004;67(3):401-10.
2004: Baraldi Pier Giovanni; Romagnoli Romeo; Del Carmen Nuñez Maria; Perretti Mauro; Paul-Clark Mark J; Ferrario Massimiliano; Govoni Mirco; Benedini Francesca; Ongini Ennio
Synthesis of nitro esters of prednisolone, new compounds combining pharmacological properties of both glucocorticoids and nitric oxide.
Journal of medicinal chemistry 2004;47(3):711-9.
2004: Baraldi Pier Giovanni; Di Virgilio Francesco; Romagnoli Romeo
Agonists and antagonists acting at P2X7 receptor.
Current topics in medicinal chemistry 2004;4(16):1707-17.
2004: Baraldi Pier Giovanni; Nûnez Maria del Carmen; Espinosa Antonio; Romagnoli Romeo
Distamycin A as stem of DNA minor groove alkylating agents.
Current topics in medicinal chemistry 2004;4(2):231-9.
2003: Boschi Alessandra; Uccelli Licia; Duatti Adriano; Bolzati Cristina; Refosco Fiorenzo; Tisato Francesco; Romagnoli Romeo; Baraldi Pier Giovanni; Varani Katia; Borea Pier Andrea
Asymmetrical nitrido tc-99m heterocomplexes as potential imaging agents for benzodiazepine receptors.
Bioconjugate chemistry 2003;14(6):1279-88.
2003: Merighi Stefania; Mirandola Prisco; Varani Katia; Gessi Stefania; Leung Edward; Baraldi Pier Giovanni; Tabrizi Mojgan Aghazadeh; Borea Pier Andrea
A glance at adenosine receptors: novel target for antitumor therapy.
Pharmacology & therapeutics 2003;100(1):31-48.
2003: Pastorin Giorgia; Da Ros Tatiana; Spalluto Giampiero; Deflorian Francesca; Moro Stefano; Cacciari Barbara; Baraldi Pier Giovanni; Gessi Stefania; Varani Katia; Borea Pier Andrea
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A 3 and A 2B adenosine receptor subtypes: a molecular modeling investigation.
Journal of medicinal chemistry 2003;46(20):4287-96.
2003: Baraldi Pier Giovanni; Bovero Andrea; Fruttarolo Francesca; Romagnoli Romeo; Tabrizi Mojgan Aghazadeh; Preti Delia; Varani Katia; Borea Pier Andrea; Moorman Allan R
New strategies for the synthesis of A3 adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2003;11(19):4161-9.
2003: Merighi Stefania; Mirandola Prisco; Varani Katia; Gessi Stefania; Capitani Silvano; Leung Edward; Baraldi Pier Giovanni; Tabrizi Mojgan Aghazadeh; Borea Pier Andrea
Pyrazolotriazolopyrimidine derivatives sensitize melanoma cells to the chemotherapic drugs: taxol and vindesine.
Biochemical pharmacology 2003;66(5):739-48.
2003: Baraldi Pier Giovanni; Romagnoli Romeo; Bianchi Nicoletta; Gambari Roberto
Benzoyl nitrogen mustard derivatives of benzoheterocyclic analogues of netropsin: synthesis and biological activity.
Bioorganic & medicinal chemistry 2003;11(11):2381-8.
2003: Baraldi Pier Giovanni; Tabrizi Mojgan Aghazadeh; Bovero Andrea; Avitabile Barbara; Preti Delia; Fruttarolo Francesca; Romagnoli Romeo; Varani Katia; Borea Pier Andrea
Recent developments in the field of A2A and A3 adenosine receptor antagonists.
European journal of medicinal chemistry 2003;38(4):367-82.
2003: Baraldi Pier Giovanni; del Carmen Nuñez Maria; Morelli Anna; Falzoni Simonetta; Di Virgilio Francesco; Romagnoli Romeo
Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor.
Journal of medicinal chemistry 2003;46(8):1318-29.
2003: Baraldi Pier Giovanni; Fruttarolo Francesca; Tabrizi Mojgan Aghazadeh; Preti Delia; Romagnoli Romeo; El-Kashef Hussein; Moorman Allan; Varani Katia; Gessi Stefania; Merighi Stefania; Borea Pier Andrea
Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.
Journal of medicinal chemistry 2003;46(7):1229-41.
2003: Baraldi Pier Giovanni; Beria Italo; Cozzi Paolo; Bianchi Nicoletta; Gambari Roberto; Romagnoli Romeo
Synthesis and growth inhibition activity of alpha-bromoacrylic heterocyclic and benzoheterocyclic derivatives of distamycin A modified on the amidino moiety.
Bioorganic & medicinal chemistry 2003;11(6):965-75.
2003: Baraldi Pier Giovanni; Romagnoli Romeo; Pavani Maria Giovanna; Nuñez Maria del Carmen; Tabrizi Mojgan Aghazadeh; Shryock John C; Leung Edward; Moorman Allan R; Uluoglu Canan; Iannotta Valeria; Merighi Stefania; Borea Pier Andrea
Synthesis and biological effects of novel 2-amino-3-naphthoylthiophenes as allosteric enhancers of the A1 adenosine receptor.
Journal of medicinal chemistry 2003;46(5):794-809.
2003: Baraldi Pier Giovanni; Tabrizi Mojgan Aghazadeh; Pavani Maria Giovanna; Nuñez Maria del Carmen; Makaeva Rimma; Gambari Roberto; La Colla Paolo; Romagnoli Romeo
Design, synthesis and in vitro cytotoxicity of a cis-dichloroplatinum (II) complex linked to the minor groove binder stallimycin.
Arzneimittel-Forschung 2003;53(2):107-13.
2002: Merighi Stefania; Mirandola Prisco; Milani Daniela; Varani Katia; Gessi Stefania; Klotz Karl-Norbert; Leung Edward; Baraldi Pier Giovanni; Borea Pier Andrea
Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells.
The Journal of investigative dermatology 2002;119(4):923-33.
2002: Baraldi Pier Giovanni; Romagnoli Romeo; Guadix Antonio Entrena; Pineda de las Infantas Maria Josè; Gallo Miguel Angel; Espinosa Antonio; Martinez Alberto; Bingham John P; Hartley John A
Design, synthesis, and biological activity of hybrid compounds between uramustine and DNA minor groove binder distamycin A.
Journal of medicinal chemistry 2002;45(17):3630-8.
2002: Maconi Anna; Pastorin Giorgia; Da Ros Tatiana; Spalluto Giampiero; Gao Zhan-Guo; Jacobson Kenneth A; Baraldi Pier Giovanni; Cacciari Barbara; Varani Katia; Moro Stefano; Borea Pier Andrea
Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist.
Journal of medicinal chemistry 2002;45(17):3579-82.
2002: Baraldi Pier Giovanni; Romagnoli Romeo; Giovanna Pavani Maria; del Carmen Nunez Maria; Bingham John P; Hartley John A
Benzoyl and cinnamoyl nitrogen mustard derivatives of benzoheterocyclic analogues of the tallimustine: synthesis and antitumour activity.
Bioorganic & medicinal chemistry 2002;10(5):1611-8.
2002: Baraldi Pier Giovanni; Cacciari Barbara; Moro Stefano; Spalluto Giampiero; Pastorin Giorgia; Da Ros Tatiana; Klotz Karl-Norbert; Varani Katia; Gessi Stefania; Borea Pier Andrea
Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists.
Journal of medicinal chemistry 2002;45(4):770-80.
2002: Gessi Stefania; Varani Katia; Merighi Stefania; Cattabriga Elena; Iannotta Valeria; Leung Edward; Baraldi Pier Giovanni; Borea Pier Andrea
A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: a pharmacological and biochemical study.
Molecular pharmacology 2002;61(2):415-24.
2002: Baraldi Pier Giovanni; Pavani Maria Giovanna; Nuñez Maria del Carmen; Brigidi Patrizia; Vitali Beatrice; Gambari Roberto; Romagnoli Romeo
Antimicrobial and antitumor activity of N-heteroimmine-1,2,3-dithiazoles and their transformation in triazolo-, imidazo-, and pyrazolopirimidines.
Bioorganic & medicinal chemistry 2002;10(2):449-56.
2002: Merighi Stefania; Varani Katia; Gessi Stefania; Klotz Karl Norbert; Leung Edward; Baraldi Pier Giovanni; Borea Pier Andrea
Binding thermodynamics at the human A(3) adenosine receptor.
Biochemical pharmacology 2002;63(2):157-61.
2002: Baraldi Pier Giovanni; Cacciari Barbara; Romagnoli Romeo; Spalluto Giampiero; Monopoli Angela; Ongini Ennio; Varani Katia; Borea Pier Andrea
7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: a study on the importance of modifications at the side chain on the activity and solubility.
Journal of medicinal chemistry 2002;45(1):115-26.
2002: Baraldi Pier Giovanni; Cacciari Barbara; Borean Pier Andrea; Varanin Katia; Pastorin Giorgia; Da Ros Tatiana; Tabrizi Mojgan Aghazadeh; Fruttarolo Francesca; Spalluto Giampiero
Pyrazolo-triazolo-pyrimidine derivatives as adenosine receptor antagonists: a possible template for adenosine receptor subtypes?
Current pharmaceutical design 2002;8(26):2299-332.
2002: Baraldi Pier Giovanni; Makaeva Rimma; Pavani Maria Giovanna; Nuñez Maria del Carmen; Spalluto Giampiero; Moro Stefano; Falzoni Simonetta; Di Virgilio Francesco; Romagnoli Romeo
Synthesis, biological activity and molecular modeling studies of 1,2,3,4-tetrahydroisoquinoline derivatives as conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor containing a tyrosine moiety.
Arzneimittel-Forschung 2002;52(4):273-85.
2001: Gessi S; Varani K; Merighi S; Morelli A; Ferrari D; Leung E; Baraldi P G; Spalluto G; Borea P A
Pharmacological and biochemical characterization of A3 adenosine receptors in Jurkat T cells.
British journal of pharmacology 2001;134(1):116-26.
2001: Baraldi P G; Cacciari B; Moro S; Romagnoli R; Ji Xd; Jacobson K A; Gessi S; Borea P A; Spalluto G
Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies.
Journal of medicinal chemistry 2001;44(17):2735-42.
2001: Baraldi P G; Balboni G; Pavani M G; Spalluto G; Tabrizi M A; Clercq E D; Balzarini J; Bando T; Sugiyama H; Romagnoli R
Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.
Journal of medicinal chemistry 2001;44(16):2536-43.
2001: Manfredini S; Baraldi P G; Durini E; Porcu L; Angusti A; Vertuani S; Solaroli N; De Clercq E; Karlsson A; Balzarini J
Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(10):1329-32.
2000: Baraldi P G; Borea P A
New potent and selective human adenosine A(3) receptor antagonists.
Trends in pharmacological sciences 2000;21(12):456-9.
2000: Baraldi P G; Zaid A N; Lampronti I; Fruttarolo F; Pavani M G; Tabrizi M A; Shryock J C; Leung E; Romagnoli R
Synthesis and biological effects of a new series of 2-amino-3-benzoylthiophenes as allosteric enhancers of A1-adenosine receptor.
Bioorganic & medicinal chemistry letters 2000;10(17):1953-7.
2000: Baraldi P G; Cacciari B; Guiotto A; Romagnoli R; Spalluto G; Leoni A; Bianchi N; Feriotto G; Rutigliano C; Mischiati C; Gambari R
[2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid inhibits DNA binding to transcription factor Sp1.
Nucleosides, nucleotides & nucleic acids 2000;19(8):1219-29.
2000: Baraldi P G; Romagnoli R; Beria I; Cozzi P; Geroni C; Mongelli N; Bianchi N; Mischiati C; Gambari R
Synthesis and antitumor activity of new benzoheterocyclic derivatives of distamycin A.
Journal of medicinal chemistry 2000;43(14):2675-84.
2000: Baraldi P G; Romagnoli R; Duatti A; Bolzati C; Piffanelli A; Bianchi N; Mischiati C; Gambari R
Synthesis of hybrid distamycin-cysteine labeled with 99mTc: a model for a novel class of cancer imaging agents.
Bioorganic & medicinal chemistry letters 2000;10(12):1397-400.
2000: Varani K; Merighi S; Gessi S; Klotz K N; Leung E; Baraldi P G; Cacciari B; Romagnoli R; Spalluto G; Borea P A
[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.
Molecular pharmacology 2000;57(5):968-75.
2000: Manfredini S; Baraldi P G; Bazzanini R; Durini E; Vertuani S; Pani A; Marceddu T; Demontis F; Vargiu L; La Colla P
Pyrazole related nucleosides 5. Synthesis and biological activity of 2'-deoxy-2',3'-dideoxy- and acyclo-analogues of 4-iodo-1-beta-D-ribofuranosyl-3-carboxymethyl pyrazole (IPCAR).
Nucleosides, nucleotides & nucleic acids 2000;19(4):705-22.
2000: Baraldi P G; Romagnoli R; Tabrizi M A; Falzoni S; di Virgilio F
Synthesis of conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor.
Bioorganic & medicinal chemistry letters 2000;10(7):681-4.
2000: Baraldi P G; Romagnoli R; Spalluto G; Cozzi P; Mongelli N; Bianchi N; Gambari R
DNA sequence-recognizing properties of minor groove alkylating agents. Effects of the replacement of N-methylpyrrole by an N-methylimidazole on tallimustine and its own homologue.
Arzneimittel-Forschung 2000;50(3):309-15.
2000: Baraldi P G; Cacciari B; Romagnoli R; Merighi S; Varani K; Borea P A; Spalluto G
A(3) adenosine receptor ligands: history and perspectives.
Medicinal research reviews 2000;20(2):103-28.
2000: Baraldi P G; Cacciari B; Romagnoli R; Varani K; Merighi S; Gessi S; Borea P A; Leung E; Hickey S L; Spalluto G
Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors.
Bioorganic & medicinal chemistry letters 2000;10(3):209-11.
1999: Baraldi P G; Cacciari B; Romagnoli R; Spalluto G
1H-pyrazolo[2,3-d][1,2,4]triazine-3,7-diones as a new class of human leukocyte elastase inhibitors.
Arzneimittel-Forschung 1999;49(12):997-1000.
1999: Baraldi P G; Balboni G; Cacciari B; Guiotto A; Manfredini S; Romagnoli R; Spalluto G; Thurston D E; Howard P W; Bianchi N; Rutigliano C; Mischiati C; Gambari R
Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo[2,1-c][1, 4]benzodiazepine and minor-groove-binding oligopyrrole carriers.
Journal of medicinal chemistry 1999;42(25):5131-41.
1999: Baraldi P G; Cacciari B; Romagnoli R; Spalluto G; Klotz K N; Leung E; Varani K; Gessi S; Merighi S; Borea P A
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists.
Journal of medicinal chemistry 1999;42(22):4473-8.
1999: Baraldi P G; Cacciari B; Romagnoli R; Spalluto G; Boyce C W; Boger D L
Resolution of a CPzI precursor, synthesis and biological evaluation of (+) and (-)-N-Boc-CPzI: a further validation of the relationship between chemical solvolytic stability and cytotoxicity.
Bioorganic & medicinal chemistry letters 1999;9(21):3087-92.
1999: Manfredini S; Baraldi P G; Durini E; Vertuani S; Balzarini J; De Clercq E; Karlsson A; Buzzoni V; Thelander L
5'-Phosphoramidates and 5'-diphosphates of 2'-O-allyl-beta-D-arabinofuranosyluracil, -cytosine, and -adenine: inhibition of ribonucleotide reductase.
Journal of medicinal chemistry 1999;42(17):3243-50.
1999: Thurston D E; Bose D S; Howard P W; Jenkins T C; Leoni A; Baraldi P G; Guiotto A; Cacciari B; Kelland L R; Foloppe M P; Rault S
Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines.
Journal of medicinal chemistry 1999;42(11):1951-64.
1999: Manfredini S; Baraldi P G; Durini E; Balzarini J; De Clercq E; Karlsson A; Buzzoni V; Thelander L
Synthesis, cytostatic activity and inhibition of ribonucleotide reductase by 5'-phosphoramidates and 5'-diphosphates, of 2'-O-allyl-arabinofuranosyl nucleosides.
Nucleosides & nucleotides 1999;18(4-5):1007-8.
1999: Baraldi P G; Balboni G; Romagnoli R; Spalluto G; Cozzi P; Geroni C; Mongelli N; Rutigliano C; Bianchi N; Gambari R
PNU 157977: a new potent antitumour agent exhibiting low in vivo toxicity in mice injected with L1210 leukaemia cells.
Anti-cancer drug design 1999;14(1):71-6.
1999: Baraldi P G; Cozzi P; Geroni C; Mongelli N; Romagnoli R; Spalluto G
Novel benzoyl nitrogen mustard derivatives of pyrazole analogues of distamycin A: synthesis and antileukemic activity.
Bioorganic & medicinal chemistry 1999;7(2):251-62.
1999: Baraldi P G; Cacciari B; Guiotto A; Romagnoli R; Zaid A N; Spalluto G
DNA minor-groove binders: results and design of new antitumor agents.
Farmaco (Società chimica italiana : 1989) 1999;54(1-2):15-25.
1998: Baraldi P G; Cacciari B; Guiotto A; Leoni A; Romagnoli R; Spalluto G; Mongelli N; Howard P W; Thurston D E; Bianchi N; Gambari R
Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid.
Bioorganic & medicinal chemistry letters 1998;8(21):3019-24.
1998: Guiotto A; Howard P W; Baraldi P G; Thurston D E
Synthesis of novel C7-aryl substituted pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) via pro-N10-Troc protection and Suzuki coupling.
Bioorganic & medicinal chemistry letters 1998;8(21):3017-8.
1998: Baraldi P G; Cacciari B; Pineda de Las Infantas M J; Romagnoli R; Spalluto G; Volpini R; Costanzi S; Vittori S; Cristalli G; Melman N; Park K S; Ji X D; Jacobson K A
Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5'-N-ethyluronamide as A1 and A3 adenosine receptor agonists.
Journal of medicinal chemistry 1998;41(17):3174-85.
1998: Baraldi P G; Cacciari B; Guiotto A; Romagnoli R; Zaid A N; Spalluto G
Heterocyclic analogs of DNA minor groove alkylating agents.
Current pharmaceutical design 1998;4(3):249-76.
1998: Baraldi P G; Cacciari B; Spalluto G; Bergonzoni M; Dionisotti S; Ongini E; Varani K; Borea P A
Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists.
Journal of medicinal chemistry 1998;41(12):2126-33.
1998: Manfredini S; Baraldi P G; Bazzanini R; Bortolotti F; Vertuani S; Ashida N; Machida H
Enzymatic synthesis of 2'-O-acyl prodrugs of 1-(beta-D-arabinofuranosyl)-5(E)-(2-bromovinyl)uracil and of 2'-O-acyl-araU, -araC and -araA.
Antiviral chemistry & chemotherapy 1998;9(1):25-31.
1998: Varani K; Cacciari B; Baraldi P G; Dionisotti S; Ongini E; Borea P A
Binding affinity of adenosine receptor agonists and antagonists at human cloned A3 adenosine receptors.
Life sciences 1998;63(5):PL 81-7.
1997: Baraldi P G; Cacciari B; Guiotto A; Romagnoli R; Spalluto G; Zaid A N; Capolongo L; Cozzi P; Geroni C; Mongelli N
Synthesis, solvolytic stability and cytotoxicity of a modified derivative of CPzI, a pyrazole analog of the alkylation subunit of the antitumor agent CC-1065: effect of the nitrogen substitution on the functional reactivity.
Farmaco (Società chimica italiana : 1989) 1997;52(12):717-23.
1997: Baraldi P G; Cacciari B; Guiotto A; Romagnoli R; Spalluto G; Zaid A N; Cozzi P; Geroni C; Mongelli N
Synthesis, cytotoxicity and antitumor activity of some new simplified pyrazole analogs of the antitumor agent CC-1065. Effect of an hydrophobic group on antitumor activity.
Farmaco (Società chimica italiana : 1989) 1997;52(12):711-6.
1997: Baraldi P G; Cacciari B; Romagnoli R; Spalluto G; Gambari R; Bianchi N; Passadore M; Ambrosino P; Mongelli N; Cozzi P; Geroni C
Synthesis, cytotoxicity, antitumor activity and sequence selective binding of two pyrazole analogs structurally related to the antitumor agents U-71,184 and adozelesin.
Anti-cancer drug design 1997;12(7):555-76.
1997: Baraldi P G; Cacciari B; Pineda de las Infantas M J; Romagnoli R; Spalluto G; Cozzi P; Mongelli N
Synthesis, chemical solvolytic stability and preliminary biological evaluation of (+/-)-N-Boc-CPzI: a pyrazole analog of the left-hand segment of the antitumor agent CC-1065.
Anti-cancer drug design 1997;12(1):67-74.
1996: Baraldi P G; Cacciari B; Romagnoli R; Spalluto G; Garuti L; Roberti M; Pani A; Perra G; Scintu F; Pinna N; Musiu C; La Colla P
Synthesis, antiviral and antiproliferative activity of a new class of 5-(alkyl or arylthio)-6-vinyl uracils.
Anti-cancer drug design 1996;11(8):597-609.
1996: Baraldi P G; Cacciari B; Dalpiaz A; Dionisotti S; Zocchi C; Pineda de las Infantas M J; Spalluto G; Varani K
1H-pyrazolo[4,3-d]pyrimidine-7(6H)-one and 5H-pyrazolo[4,3-d] 1,2,3-triazin-4(3H)-one derivatives. Synthesis and in vitro biological activity at adenosine A1 and A2a receptors.
Arzneimittel-Forschung 1996;46(4):365-8.
1996: Zocchi C; Ongini E; Ferrara S; Baraldi P G; Dionisotti S
Binding of the radioligand [3H]-SCH 58261, a new non-xanthine A2A adenosine receptor antagonist, to rat striatal membranes.
British journal of pharmacology 1996;117(7):1381-6.
1996: Manfredini S; Bazzanini R; Baraldi P G; Bonora M; Marangoni M; Simoni D; Pani A; Scintu F; Pinna E; Pisano L; La Colla P
Pyrazole-related nucleosides. 4. Synthesis and antitumor activity of some 1-tetrahydropyranyl-4-substituted pyrazoles.
Anti-cancer drug design 1996;11(3):193-204.
1996: Baraldi P G; Cacciari B; Spalluto G; Pineda de las Infants M J; Zocchi C; Ferrara S; Dionisotti S; FerraDDionisotti S
1,2,3-Triazolo[5,4-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: a new class of A2A adenosine receptor antagonists.
Farmaco (Società chimica italiana : 1989) 1996;51(4):297-300.
1996: Baraldi P G; Cacciari B; Spalluto G; Pineda de las Infantas y Villatoro M J; Zocchi C; Dionisotti S; Ongini E
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives: potent and selective A(2A) adenosine antagonists.
Journal of medicinal chemistry 1996;39(5):1164-71.
1996: Zocchi C; Ongini E; Conti A; Monopoli A; Negretti A; Baraldi P G; Dionisotti S
The non-xanthine heterocyclic compound SCH 58261 is a new potent and selective A2a adenosine receptor antagonist.
The Journal of pharmacology and experimental therapeutics 1996;276(2):398-404.
1996: Baraldi P G; Cacciari B; Spalluto G; Ji X D; Olah M E; Stiles G; Dionisotti S; Zocchi C; Ongini E; Jacobson K A
Novel N6-(substituted-phenylcarbamoyl)adenosine-5'-uronamides as potent agonists for A3 adenosine receptors.
Journal of medicinal chemistry 1996;39(3):802-6.
1995: Manfredini S; Baraldi P G; Bazzanini R; Marangoni M; Simoni D; Balzarini J; De Clercq E
Synthesis and cytotoxic activity of 6-vinyl- and 6-ethynyluridine and 8-vinyl-and 8-ethynyladenosine.
Journal of medicinal chemistry 1995;38(1):199-203.
1994: Baraldi P G; Leoni A; Cacciari B; Manfredini S; Simoni D; Bergomi M; Menta E; Spinelli S
Synthesis and antitumor activity of a new class of pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone analogues of pyrrolo[1,4][2,1-c]benzodiazepines.
Journal of medicinal chemistry 1994;37(25):4329-37.
1994: Manfredini S; Baraldi P G; Bazzanini R; Guarneri M; Simoni D; Balzarini J; De Clercq E
Geiparvarin analogues. 4. Synthesis and cytostatic activity of geiparvarin analogues bearing a carbamate moiety or a furocoumarin fragment on the alkenyl side chain.
Journal of medicinal chemistry 1994;37(15):2401-5.
1993: Garuti L; Ghedini N; Leoni A; Baraldi P G; Dionisotti S
Design and synthesis of 3-(benzimidazol-2-yl)-propionic acids as thromboxane A2 receptor antagonists.
Farmaco (Società chimica italiana : 1989) 1993;48(11):1531-46.
1993: Baraldi P G; Garuti L; Leoni A; Cacciari B; Budriesi R; Chiarini A
Synthesis and cardiodepressant activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-(pentatomic-heteroaryl)-3,5-pyridine-dicarbo xylates. 2.
Drug design and discovery 1993;10(4):319-29.
1992: Baraldi P G; Manfredini S; Simoni D; Tabrizi M A; Balzarini J; De Clercq E
Geiparvarin analogues. 3. Synthesis and cytostatic activity of 3(2H)-furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain.
Journal of medicinal chemistry 1992;35(10):1877-82.
1992: Manfredini S; Bazzanini R; Baraldi P G; Guarneri M; Simoni D; Marongiu M E; Pani A; Tramontano E; La Colla P
Pyrazole-related nucleosides. Synthesis and antiviral/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides.
Journal of medicinal chemistry 1992;35(5):917-24.
1992: Simoni D; Manfredini S; Tabrizi M A; Bazzanini R; Baraldi P G; Ferroni R; Traniello F; Nastruzzi C; Feriotto G; Gambari R
New isoxazole derivatives of retinoids: synthesis and activity on growth and differentiation of tumor cells.
Drug design and discovery 1992;8(3):165-77.
1991: Simoni D; Manfredini S; Tabrizi M A; Bazzanini R; Baraldi P G; Balzarini J; De Clercq E
Geiparvarin analogues. 2. Synthesis and cytostatic activity of 5-(4-arylbutadienyl)-3(2H)-furanones and of N-substituted 3-(4-oxo-2-furanyl)-2-buten-2-yl carbamates.
Journal of medicinal chemistry 1991;34(11):3172-6.
1991: Baraldi P G; Cacciari B; Leoni A; Recanatini M; Roberti M; Rossi M; Manfredini S; Periotto V; Simoni D
Synthesis, antibacterial activity and structure-activity relationships of N-substituted 4-diazo-pyrazole-5-carboxamides. 2.
Farmaco (Società chimica italiana : 1989) 1991;46(11):1337-50.
1990: Beani L; Bianchi C; Baraldi P G; Manfredini S; Pollini G P
Protection by pyroglutamic acid and some of its newly synthesized derivatives against glutamate-induced seizures in mice.
Arzneimittel-Forschung 1990;40(11):1187-91.
1989: Baraldi P G; Brigidi P; Casolari A; Manfredini S; Periotto V; Recanatini M; Roberti M; Rossi M
Synthesis, antibacterial activity and structure-activity relationships of N-substituted 3-methyl-4-diazo-5-pyrazolecarboxamides.
Arzneimittel-Forschung 1989;39(11):1406-10.
1989: Nastruzzi C; Simoni D; Manfredini S; Barbieri R; Feriotto G; Baraldi P G; Spandidos D; Guarneri M; Gambari R
New synthetic retinoids: effects on proliferation and differentiation.
Anticancer research 1989;9(5):1377-83.
1989: Baraldi P G; Guarneri M; Manfredini S; Simoni D; Zanirato V
[Synthesis and evaluation of the antifungal activity of a new series of N-acylureas]
Farmaco (Società chimica italiana : 1989) 1989;44(4):391-8.
1989: Baraldi P G; Guarneri M; Manfredini S; Simoni D; Balzarini J; De Clercq E
Synthesis and cytostatic activity of geiparvarin analogues.
Journal of medicinal chemistry 1989;32(2):284-8.
1988: Baraldi P G; Casolari A; Manfredini S; Periotto V; Zanirato V; Florio C; Traversa V; Bertelli G M; Borea P A
Synthesis of 1H-pyrazolo[4,3-d]pyrimidine-7(6H)-ones and pyrazolo-5-carboxamides and interaction with benzodiazepine and adenosine A1 receptors in rat cerebral cortex.
Arzneimittel-Forschung 1988;38(9):1262-5.
1985: Baraldi P G; Manfredini S; Periotto V; Simoni D; Guarneri M; Borea P A
Synthesis and interaction of 5-(substituted-phenyl)-3-methyl-6,7-dihydropyrazolo[4,3-e] [1,4]diazepin-8(7H)-ones with benzodiazepine receptors in rat cerebral cortex.
Journal of medicinal chemistry 1985;28(5):683-5.
1984: Baraldi P G; Simoni D; Periotto V; Manfredini S; Guarneri M; Manservigi R; Cassai E; Bertolasi V
Pyrazolo[4,3-d]pyrimidine nucleosides. Synthesis and antiviral activity of 1-beta-D-ribofuranosyl-3-methyl-6-substituted-7H-pyrazolo[4,3-d]pyr imi din-7-ones.
Journal of medicinal chemistry 1984;27(8):986-90.
1983: Baraldi P G; Simoni D; Casolari A; Manfredini S
Azaprostaglandins. Synthesis and antiulcer activity of 11-deoxy-8-azaprostaglandin analogues.
Il Farmaco; edizione scientifica 1983;38(7):498-507.
1983: Baraldi P G; Vicentini C B; Simoni D; Menziani E
[Synthesis of pyrazole and pyrazolo [4,3-d] pyrimidinone derivatives. II]
Il Farmaco; edizione scientifica 1983;38(7):508-13.
1983: Baraldi P G; Vicentini C B; Simoni D; Guarneri M
[Synthesis of pyrazole derivatives and pyrazolo[4,3-d]pyrimidines. I]
Il Farmaco; edizione scientifica 1983;38(6):370-5.
1983: Borea P A; Bonora A; Baraldi P G; Simoni D
Brain receptor binding of analogues of gamma-aminobutyric acid (GABA).
Il Farmaco; edizione scientifica 1983;38(6):411-7.
1981: Barco A; Benetti S; Pollini G P; Baraldi P G; Guarneri M; Gandolfi C; Ceserani R; Longiave D
Azaprostaglandin analogues. Synthesis and biological properties of 11-azaprostaglandin derivatives.
Journal of medicinal chemistry 1981;24(5):625-8.
1980: Baraldi P G; Dalla Vecchia F; Guarneri M; Vicentini C B; Ceserani R
[Synthesis of compounds with antisecretory activity]
Il Farmaco; edizione scientifica 1980;35(8):698-705.
1980: Vicentini C B; Veronese A C; Giori P; Baraldi P G; Guarneri M
Carboxyl activation in peptide synthesis using 4-oximino-pyrazol-5-ones.
International journal of peptide and protein research 1980;16(1):48-54.

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