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Jiing-Dwan Lee

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Runqiang Chen; Qingkai Yang; Jiing-Dwan Lee
BMK1 kinase suppresses epithelial-mesenchymal transition through the Akt/GSK3β signaling pathway.
Yuji Takaoka; Koichi Adachi; Michinari Hamaguchi; Hitoki Hasegawa; Masatoshi Ichihara; Jiing-Dwan Lee; Miki Nagahara; Yasuo Ouchi; Shanlou Qiao; Yuko Shimizu; Takashi Iwamoto
Forced expression of miR-143 represses ERK5/c-Myc and p68/p72 signaling in concert with miR-145 in gut tumors of Apc(Min) mice.
Matthew P Patricelli; Helge Weissig; Jiangyue Wu; Qingkai Yang; Jianming Zhang; David Zhou; Arwin Aban; Heidi Brown; Nathanael S Gray; Chris Herring; Subadhra Jagannathan; Jiing-Dwan Lee; Tyzoon K Nomanbhoy; Brian Nordin; Eric Okerberg; John W Kozarich
In situ kinase profiling reveals functionally relevant properties of native kinases.

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All Publications

2012: Runqiang Chen; Qingkai Yang; Jiing-Dwan Lee
BMK1 kinase suppresses epithelial-mesenchymal transition through the Akt/GSK3β signaling pathway.
Cancer research 2012;72(6):1579-87.
2012: Yuji Takaoka; Koichi Adachi; Michinari Hamaguchi; Hitoki Hasegawa; Masatoshi Ichihara; Jiing-Dwan Lee; Miki Nagahara; Yasuo Ouchi; Shanlou Qiao; Yuko Shimizu; Takashi Iwamoto
Forced expression of miR-143 represses ERK5/c-Myc and p68/p72 signaling in concert with miR-145 in gut tumors of Apc(Min) mice.
PloS one 2012;7(8):e42137.
2011: Matthew P Patricelli; Helge Weissig; Jiangyue Wu; Qingkai Yang; Jianming Zhang; David Zhou; Arwin Aban; Heidi Brown; Nathanael S Gray; Chris Herring; Subadhra Jagannathan; Jiing-Dwan Lee; Tyzoon K Nomanbhoy; Brian Nordin; Eric Okerberg; John W Kozarich
In situ kinase profiling reveals functionally relevant properties of native kinases.
Chemistry & biology 2011;18(6):699-710.
2011: Qingkai Yang; Jiing-Dwan Lee
Targeting the BMK1 MAP kinase pathway in cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(11):3527-32.
2011: Xianming Deng; Nicolas Dzamko; Alan Prescott; Paul Davies; Qingsong Liu; Qingkai Yang; Jiing-Dwan Lee; Matthew P Patricelli; Tyzoon K Nomanbhoy; Dario R Alessi; Nathanael S Gray
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.
Nature chemical biology 2011;7(4):203-5.
2010: Qingkai Yang; Xianming Deng; Bingwen Lu; Michael Cameron; Colleen Fearns; Matthew P Patricelli; John R Yates; Nathanael S Gray; Jiing-Dwan Lee
Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein.
Cancer cell 2010;18(3):258-67.
2009: Run-Qiang Chen; Qing-Kai Yang; Yan-Ling Chen; Vasco A Oliveira; William S Dalton; Colleen Fearns; Jiing-Dwan Lee
Kinome siRNA screen identifies SMG-1 as a negative regulator of hypoxia-inducible factor-1alpha in hypoxia.
The Journal of biological chemistry 2009;284(25):16752-8.
2009: Yanling Chen; bingwen lu; Qingkai Yang; Colleen Fearns; John R Yates; Jiing-Dwan Lee
Combined integrin phosphoproteomic analyses and small interfering RNA--based functional screening identify key regulators for cancer cell adhesion and migration.
Cancer research 2009;69(8):3713-20.
2009: Run-Qiang Chen; Qing-Kai Yang; bingwen lu; Wei Yi; Greg T Cantin; Yan-Ling Chen; Colleen Fearns; John R Yates; Jiing-Dwan Lee
CDC25B mediates rapamycin-induced oncogenic responses in cancer cells.
Cancer research 2009;69(6):2663-8.
2008: J-H Zhu; R Chen; W Yi; Greg T Cantin; Colleen Fearns; Y Yang; John R Yates; Jiing-Dwan Lee
Protein tyrosine phosphatase PTPN13 negatively regulates Her2/ErbB2 malignant signaling.
Oncogene 2008;27(18):2525-31.
2008: Greg T Cantin; Wei Yi; bingwen lu; Sung Kyu Park; Tao Xu; Jiing-Dwan Lee; John R Yates
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
Journal of proteome research 2008;7(3):1346-51.
2006: Shahrzad Abbasi; Jiing-Dwan Lee; Bing Su; Xiang Chen; Joseph L Alcon; Jianhua Yang; Rodney E Kellems; Yang Xia
Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1.
The Journal of biological chemistry 2006;281(12):7717-26.
2006: Masaaki Hayashi; Kyoko Imanaka-Yoshida; Toshimichi Yoshida; Malcolm Wood; Colleen Fearns; Revati J Tatake; Jiing-Dwan Lee
A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy.
Nature medicine 2006;12(1):128-32.
2005: Sung-Woo Kim; Masaaki Hayashi; Jeng-Fan Lo; Colleen Fearns; Rong Xiang; Gwendal Lazennec; Young Yang; Jiing-Dwan Lee
Tid1 negatively regulates the migratory potential of cancer cells by inhibiting the production of interleukin-8.
Cancer research 2005;65(19):8784-91.
2005: Masaaki Hayashi; Colleen Fearns; Brian P Eliceiri; Young Yang; Jiing-Dwan Lee
Big mitogen-activated protein kinase 1/extracellular signal-regulated kinase 5 signaling pathway is essential for tumor-associated angiogenesis.
Cancer research 2005;65(17):7699-706.
2005: He Zhou; Yunping Luo; Jeng-Fan Lo; Charles D Kaplan; Masato Mizutani; Noriko Mizutani; Jiing-Dwan Lee; F James Primus; Jürgen C Becker; Rong Xiang; Ralph A Reisfeld
DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the NKG2D receptor.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):10846-51.
2005: Jeng-Fan Lo; He Zhou; Colleen Fearns; Ralph A Reisfeld; Young Yang; Jiing-Dwan Lee
Tid1 is required for T cell transition from double-negative 3 to double-positive stages.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6105-12.
2004: Masaaki Hayashi; Jiing-Dwan Lee
Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice.
Journal of molecular medicine (Berlin, Germany) 2004;82(12):800-8.
2004: Sung-Woo Kim; Ta-Hsiang Chao; Rong Xiang; Jeng-Fan Lo; Michael J Campbell; Colleen Fearns; Jiing-Dwan Lee
Tid1, the human homologue of a Drosophila tumor suppressor, reduces the malignant activity of ErbB-2 in carcinoma cells.
Cancer research 2004;64(21):7732-9.
2004: Scott J Cameron; Seigo Itoh; Christopher P Baines; Changxi Zhang; Shinsuke Ohta; Wenyi Che; Michael Glassman; Jiing-Dwan Lee; Chen Yan; Jay Yang; Jun-ichi Abe
Activation of big MAP kinase 1 (BMK1/ERK5) inhibits cardiac injury after myocardial ischemia and reperfusion.
FEBS letters 2004;566(1-3):255-60.
2004: Masaaki Hayashi; Sung-Woo Kim; Kyoko Imanaka-Yoshida; Toshimichi Yoshida; E Dale Abel; Brian P Eliceiri; Young Yang; Richard J Ulevitch; Jiing-Dwan Lee
Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure.
The Journal of clinical investigation 2004;113(8):1138-48.
2004: Jeng-Fan Lo; Masaaki Hayashi; Sung Woo-Kim; Bin Tian; Jing-Feng Huang; Colleen Fearns; Shinichi Takayama; Juan M Zapata; Young Yang; Jiing-Dwan Lee
Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor l(2)tid, is critical for early embryonic development and cell survival.
Molecular and cellular biology 2004;24(6):2226-36.
2004: Tapping Richard; Kato Yutaka; Ta-Hsiang Chao; Masaaki Hayashi; Jeng-Fan Lo; Sung-Woo Kim; Jiing-Dwan Lee
Investigating the cellular BMK1/ERK5 signaling pathway.
Methods in molecular biology (Clifton, N.J.) 2004;250():89-96.
2003: Scott J Cameron; Sundeep Malik; Masashi Akaike; nicole lerner-marmarosh; Chen Yan; Jiing-Dwan Lee; Jun-ichi Abe; Jay Yang
Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation.
The Journal of biological chemistry 2003;278(20):18682-8.
2003: Sung-Woo Kim; Masaaki Hayashi; Jeng-Fan Lo; Young Yang; Jin-San Yoo; Jiing-Dwan Lee
ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activation.
The Journal of biological chemistry 2003;278(4):2661-8.
2002: Wenyi Che; nicole lerner-marmarosh; Qunhua Huang; Masaki Osawa; Shinsuke Ohta; Masanori Yoshizumi; Michael Glassman; Jiing-Dwan Lee; Chen Yan; Bradford C Berk; Jun-ichi Abe
Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression.
Circulation research 2002;90(11):1222-30.
2002: Yasuchika Takeishi; Qunhua Huang; Jun-ichi Abe; Wenyi Che; Jiing-Dwan Lee; Hisaaki Kawakatsu; Brian D Hoit; Bradford C Berk; Richard A Walsh
Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy.
Cardiovascular research 2002;53(1):131-7.
2001: Yasuchika Takeishi; Qunhua Huang; T Wang; Michael Glassman; M Yoshizumi; Christopher P Baines; Jiing-Dwan Lee; Hisaaki Kawakatsu; Wenyi Che; nicole lerner-marmarosh; Changxi Zhang; Chen Yan; Shinsuke Ohta; Richard A Walsh; Bradford C Berk; Jun-ichi Abe
Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: modulation of MAP kinases activation by ischemic preconditioning.
Journal of molecular and cellular cardiology 2001;33(11):1989-2005.
2001: Yasuchika Takeishi; Qunhua Huang; Jun-ichi Abe; Michael Glassman; Wenyi Che; Jiing-Dwan Lee; Hisaaki Kawakatsu; E G Lawrence; Brian D Hoit; Bradford C Berk; Richard A Walsh
Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: comparison with acute mechanical stretch.
Journal of molecular and cellular cardiology 2001;33(9):1637-48.
2001: Chen Yan; H Luo; Jiing-Dwan Lee; Jun-ichi Abe; Bradford C Berk
Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains.
The Journal of biological chemistry 2001;276(14):10870-8.
2001: Masaaki Hayashi; Tapping Richard; Ta-Hsiang Chao; Jeng-Fan Lo; Charles C King; Young Yang; Jiing-Dwan Lee
BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase.
The Journal of biological chemistry 2001;276(12):8631-4.
2000: Y Kato; Ta-Hsiang Chao; Masaaki Hayashi; Tapping Richard; Jiing-Dwan Lee
Role of BMK1 in regulation of growth factor-induced cellular responses.
Immunologic research 2000;21(2-3):233-7.
1999: Ta-Hsiang Chao; Masaaki Hayashi; Tapping Richard; Y Kato; Jiing-Dwan Lee
MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway.
The Journal of biological chemistry 1999;274(51):36035-8.
1999: Yasuchika Takeishi; Jun-ichi Abe; Jiing-Dwan Lee; Hisaaki Kawakatsu; Richard A Walsh; Bradford C Berk
Differential regulation of p90 ribosomal S6 kinase and big mitogen-activated protein kinase 1 by ischemia/reperfusion and oxidative stress in perfused guinea pig hearts.
Circulation research 1999;85(12):1164-72.
1998: Y Kato; Tapping Richard; Shuang Huang; Mark H Watson; Richard J Ulevitch; Jiing-Dwan Lee
Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor.
Nature 1998;395(6703):713-6.
1997: Y Kato; Vladimir V Kravchenko; Tapping Richard; Jiahuai Han; Richard J Ulevitch; Jiing-Dwan Lee
BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C.
The EMBO journal 1997;16(23):7054-66.