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Kang Choon Lee

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Microspheres

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Type 2 Diabetes Mellitus

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Suntaek Hong; Hye-Youn Kim; Jooyoung Kim; Eunjin Bae; Huyen Trang Ha; Tae Hyung Kim; Young-Mi Kim; Kang Choon Lee; Seong-Jin Kim
Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis.
Hyemin Kim; Kang Choon Lee; Dooyong Jeong; Hee Eun Kang; Kun Na
A sulfate polysaccharide/TNF-related apoptosis-inducing ligand (TRAIL) complex for the long-term delivery of TRAIL in poly(lactic-co-glycolic acid) (PLGA) microspheres.
Tae Hyung Kim; Seulki Lee; Sung Mook Lim; Yu Seok Youn; Youngro Byun; Xiaoyuan Chen; Ki Young Choi; Hai Hua Jiang; Kang Choon Lee
Site-specific PEGylated Exendin-4 modified with a high molecular weight trimeric PEG reduces steric hindrance and increases type 2 antidiabetic therapeutic effects.

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2013: Suntaek Hong; Hye-Youn Kim; Jooyoung Kim; Eunjin Bae; Huyen Trang Ha; Tae Hyung Kim; Young-Mi Kim; Kang Choon Lee; Seong-Jin Kim
Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis.
The Journal of biological chemistry 2013;288(5):3560-70.
2013: Hyemin Kim; Kang Choon Lee; Dooyong Jeong; Hee Eun Kang; Kun Na
A sulfate polysaccharide/TNF-related apoptosis-inducing ligand (TRAIL) complex for the long-term delivery of TRAIL in poly(lactic-co-glycolic acid) (PLGA) microspheres.
The Journal of pharmacy and pharmacology 2013;65(1):11-21.
2012: Tae Hyung Kim; Seulki Lee; Sung Mook Lim; Yu Seok Youn; Youngro Byun; Xiaoyuan Chen; Ki Young Choi; Hai Hua Jiang; Kang Choon Lee
Site-specific PEGylated Exendin-4 modified with a high molecular weight trimeric PEG reduces steric hindrance and increases type 2 antidiabetic therapeutic effects.
Bioconjugate chemistry 2012;23(11):2214-20.
2012: Tae Hyung Kim; Seulki Lee; Sung Mook Lim; Yu Seok Youn; Youngro Byun; Xiaoyuan Chen; Hai Hua Jiang; Young Gi Jo; Kang Choon Lee
PEG-transferrin conjugated TRAIL (TNF-related apoptosis-inducing ligand) for therapeutic tumor targeting.
Journal of controlled release : official journal of the Controlled Release Society 2012;162(2):422-8.
2012: Juho Lee; Kang Choon Lee; Hyung Ryong Moon; Kyung Taek Oh; Sang-Cheol Chi; Tae Hyung Kim; Changkyu Lee; Eun Seong Lee; Yu Seok Youn
Pulmonary administered palmitic-acid modified exendin-4 peptide prolongs hypoglycemia in type 2 diabetic db/db mice.
Regulatory peptides 2012;177(1-3):68-72.
2012: Juho Lee; Kang Choon Lee; Eun-Seok Park; Beom Soo Shin; Sang-Cheol Chi; Tae Hyung Kim; Changkyu Lee; Eun Seong Lee; Yu Seok Youn
Self-assembled glycol chitosan nanogels containing palmityl-acylated exendin-4 peptide as a long-acting anti-diabetic inhalation system.
Journal of controlled release : official journal of the Controlled Release Society 2012;161(3):728-34.
2012: Insoo Kim; Tae Hyung Kim; Eun Seong Lee; Kang Choon Lee; Kyung Taek Oh; Beom Soo Shin; Hyeong Jun Byeon; Yu Seok Youn
Doxorubicin-loaded highly porous large PLGA microparticles as a sustained- release inhalation system for the treatment of metastatic lung cancer.
Biomaterials 2012;33(22):5574-83.
2012: Juho Lee; Kang Choon Lee; Hyung Ryong Moon; Kyung Taek Oh; Insoo Kim; Tae Hyung Kim; Changkyu Lee; Eun Seong Lee; Yu Seok Youn
Preparation and evaluation of palmitic acid-conjugated exendin-4 with delayed absorption and prolonged circulation for longer hypoglycemia.
International journal of pharmaceutics 2012;424(1-2):50-7.
2012: Soo-Yeon Kim; Tae Hyung Kim; Kang Choon Lee; Seung-Jin Lee; Ki Dong Park; Jong Hoon Choi; Hyo-Jeong Kuh
Evaluation of interstitial protein delivery in multicellular layers model.
Archives of pharmacal research 2012;35(3):531-41.
2012: Xinglu Huang; Kwangmeyung Kim; Kang Choon Lee; Seulki Lee; Gang Niu; Jinwoo Park; Magdalena Swierczewska; Jin Xie; Lei Zhu; Ashwinkumar Bhirde; Ki Young Choi; Xiaoyuan Chen
Multiplex imaging of an intracellular proteolytic cascade by using a broad-spectrum nanoquencher.
Angewandte Chemie (International ed. in English) 2012;51(7):1625-30.
2012: Tae Hyung Kim; Moon Hyuk Chi; Hai Hua Jiang; Hoi Yun Kim; Sung Kyung Lee; Sung Mook Lim; Chan Woong Park; Young Me Song; Yu Seok Youn; Kang Choon Lee
Low molecular weight (1 kDa) polyethylene glycol conjugation markedly enhances the hypoglycemic effects of intranasally administered exendin-4 in type 2 diabetic db/db mice.
Biological & pharmaceutical bulletin 2012;35(7):1076-83.
2011: Jae Hwa Ahn; Hye Suk Lee; Kang Choon Lee; Eun Ji Park; Dong Hee Na
Reversible blocking of amino groups of octreotide for the inhibition of formation of acylated peptide impurities in poly(lactide-co-glycolide) delivery systems.
AAPS PharmSciTech 2011;12(4):1220-6.
2011: Hai Hua Jiang; Tae Hyung Kim; Seulki Lee; Yu Seok Youn; Xiaoyuan Chen; Kang Choon Lee
PEGylated TNF-related apoptosis-inducing ligand (TRAIL) for effective tumor combination therapy.
Biomaterials 2011;32(33):8529-37.
2011: Tae Hyung Kim; Xiaoyuan Chen; Hai Hua Jiang; Seulki Lee; Yu Seok Youn; Kang Choon Lee
PEGylated TNF-related apoptosis-inducing ligand (TRAIL) analogues: pharmacokinetics and antitumor effects.
Bioconjugate chemistry 2011;22(8):1631-7.
2011: Hyunuk Kim; Tae Hyung Kim; Don Haeng Lee; Eun Seong Lee; Juho Lee; Kang Choon Lee; Kyung Taek Oh; Eun-Seok Park; You Han Bae; Yu Seok Youn
Albumin-coated porous hollow poly(lactic-co-glycolic acid) microparticles bound with palmityl-acylated exendin-4 as a long-acting inhalation delivery system for the treatment of diabetes.
Pharmaceutical research 2011;28(8):2008-19.
2011: Sung Mook Lim; Tae Hyung Kim; Hai Hua Jiang; Chan Woong Park; Seulki Lee; Xiaoyuan Chen; Kang Choon Lee
Improved biological half-life and anti-tumor activity of TNF-related apoptosis-inducing ligand (TRAIL) using PEG-exposed nanoparticles.
Biomaterials 2011;32(13):3538-46.
2011: Tae Hyung Kim; Hai Hua Jiang; Seulki Lee; Yu Seok Youn; Chan Woong Park; Youngro Byun; Xiaoyuan Chen; Kang Choon Lee
Mono-PEGylated dimeric exendin-4 as high receptor binding and long-acting conjugates for type 2 anti-diabetes therapeutics.
Bioconjugate chemistry 2011;22(4):625-32.
2011: Insoo Kim; Tae Hyung Kim; Kyungwan Ma; Eun-Seok Park; Kyung Taek Oh; Eun Seong Lee; Kang Choon Lee; Yu Seok Youn
A 4-arm polyethylene glycol derivative conjugated with exendin-4 peptide and palmitylamine having dual-function of size-increase and albumin-binding for long hypoglycemic action.
Regulatory peptides 2011;167(2-3):239-45.
2011: Yang-Gyu Choi; Ji Hae Lee; Il-Hong Bae; Young-Chang Ah; Han-Moe Ki; Jun-Ho Bae; Young-Ho Park; Kang Choon Lee; Kyung-Min Lim
Titanium dioxide inclusion in backing reduce the photoallergenicity of ketoprofen transdermal patch.
Archives of toxicology 2011;85(3):219-26.
2011: Tae Hyung Kim; Hai Hua Jiang; Chan Woong Park; Yu Seok Youn; Seulki Lee; Xiaoyuan Chen; Kang Choon Lee
PEGylated TNF-related apoptosis-inducing ligand (TRAIL)-loaded sustained release PLGA microspheres for enhanced stability and antitumor activity.
Journal of controlled release : official journal of the Controlled Release Society 2011;150(1):63-9.
2011: Hyunuk Kim; Hongil Park; Juho Lee; Tae Hyung Kim; Eun Seong Lee; Kyung Taek Oh; Kang Choon Lee; Yu Seok Youn
Highly porous large poly(lactic-co-glycolic acid) microspheres adsorbed with palmityl-acylated exendin-4 as a long-acting inhalation system for treating diabetes.
Biomaterials 2011;32(6):1685-93.
2011: Tae Hyung Kim; Hai-Hua Jiang; Yu Seok Youn; Chan Woong Park; Sung Mook Lim; Cheng-Hao Jin; Kyung Kook Tak; Hye Suk Lee; Kang Choon Lee
Preparation and characterization of Apo2L/TNF-related apoptosis-inducing ligand-loaded human serum albumin nanoparticles with improved stability and tumor distribution.
Journal of pharmaceutical sciences 2011;100(2):482-91.
2011: Tae Hyung Kim; Hai Hua Jiang; Yu Seok Youn; Chan Woong Park; Kyung Kook Tak; Seulki Lee; Hyungjun Kim; Sangyong Jon; Xiaoyuan Chen; Kang Choon Lee
Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity.
International journal of pharmaceutics 2011;403(1-2):285-91.
2010: Yu-Jeong Kim; Su Young Chae; Cheng-Hao Jin; M Sivasubramanian; Sohee Son; Ki Young Choi; Dong-Gyu Jo; Kwangmeyung Kim; Ick Chan Kwon; Kang Choon Lee; Jae Hyung Park
Ionic complex systems based on hyaluronic acid and PEGylated TNF-related apoptosis-inducing ligand for treatment of rheumatoid arthritis.
Biomaterials 2010;31(34):9057-64.
2010: Eun Ji Park; Kyung Soo Lee; Kang Choon Lee; Dong Hee Na
Application of microchip CGE for the analysis of PEG-modified recombinant human granulocyte-colony stimulating factors.
Electrophoresis 2010;31(22):3771-4.
2010: Insoo Kim; Tae Hyung Kim; Kyungwan Ma; Eun Seong Lee; Dongin Kim; Kyung Taek Oh; Don Haeng Lee; Kang Choon Lee; Yu Seok Youn
Synthesis and evaluation of human serum albumin-modified exendin-4 conjugate via heterobifunctional polyethylene glycol linkage with protracted hypoglycemic efficacy.
Bioconjugate chemistry 2010;21(8):1513-9.
2010: Eun Ji Park; Tae Hyuk Tak; Dong Hee Na; Kang Choon Lee
Effect of PEGylation on stability of peptide in poly(lactide-co-glycolide) microspheres.
Archives of pharmacal research 2010;33(7):1111-6.
2010: Su Young Chae; Tae Hyung Kim; Kyeongsoon Park; Cheng-Hao Jin; Sohee Son; Seulki Lee; Yu Seok Youn; Kwangmeyung Kim; Dong-Gyu Jo; Ick Chan Kwon; Xiaoyuan Chen; Kang Choon Lee
Improved antitumor activity and tumor targeting of NH(2)-terminal-specific PEGylated tumor necrosis factor-related apoptosis-inducing ligand.
Molecular cancer therapeutics 2010;9(6):1719-29.
2010: Su Young Chae; Yang Gyu Choi; Sohee Son; Sung Youb Jung; Doo Sung Lee; Kang Choon Lee
The fatty acid conjugated exendin-4 analogs for type 2 antidiabetic therapeutics.
Journal of controlled release : official journal of the Controlled Release Society 2010;144(1):10-6.
2010: Ji-Hyun Kong; Eun Ju Oh; Su Young Chae; Kang Choon Lee; Sei Kwang Hahn
Long acting hyaluronate--exendin 4 conjugate for the treatment of type 2 diabetes.
Biomaterials 2010;31(14):4121-8.
2010: Su Young Chae; Cheng-Hao Jin; Jae Hee Shin; Sohee Son; Tae Hyung Kim; Seulki Lee; Yu Seok Youn; Youngro Byun; Myung-Shik Lee; Kang Choon Lee
Biochemical, pharmaceutical and therapeutic properties of long-acting lithocholic acid derivatized exendin-4 analogs.
Journal of controlled release : official journal of the Controlled Release Society 2010;142(2):206-13.
2010: Cheng-Hao Jin; Su Young Chae; Tae Hyung Kim; Han-Kwang Yang; Eun Young Lee; Yeong Wook Song; Dong-Gyu Jo; Kang Choon Lee
Effect of tumor necrosis factor-related apoptosis-inducing ligand on the reduction of joint inflammation in experimental rheumatoid arthritis.
The Journal of pharmacology and experimental therapeutics 2010;332(3):858-65.
2009: Sohee Son; Su Young Chae; Chang Wan Kim; Yang Gyu Choi; Sung Youb Jung; Seulki Lee; Kang Choon Lee
Preparation and structural, biochemical, and pharmaceutical characterizations of bile acid-modified long-acting exendin-4 derivatives.
Journal of medicinal chemistry 2009;52(21):6889-96.
2009: Eun Ji Park; Kang Choon Lee; Dong Hee Na
Separation of positional isomers of mono-poly(ethylene glycol)-modified octreotides by reversed-phase high-performance liquid chromatography.
Journal of chromatography. A 2009;1216(45):7793-7.
2009: Kang Choon Lee; Young Goo Chun; Insoo Kim; Beom Soo Shin; Eun-Seok Park; Sun Dong Yoo; Yu Seok Youn
Development and validation of a reversed-phase fluorescence HPLC method for determination of bucillamine in human plasma using pre-column derivatization with monobromobimane.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(22):2130-4.
2009: Hye Won Lee; Hye Young Ji; Eun-Seok Park; Kang Choon Lee; Hye Suk Lee
Hydrophilic interaction chromatography-tandem mass spectrometric analysis of irbesartan in human plasma: application to pharmacokinetic study of irbesartan.
Journal of separation science 2009;32(14):2353-8.
2009: Dai Phu Huynh; Guang Jin Im; Su Young Chae; Kang Choon Lee; Doo Sung Lee
Controlled release of insulin from pH/temperature-sensitive injectable pentablock copolymer hydrogel.
Journal of controlled release : official journal of the Controlled Release Society 2009;137(1):20-4.
2009: Hye Won Lee; Hye Young Ji; Hoe Yoon Kim; Eun-Seok Park; Kang Choon Lee; Hye Suk Lee
Determination of metoclopramide in human plasma using hydrophilic interaction chromatography with tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(18-19):1716-20.
2009: Jung Seok Kang; Patrick P Deluca; Kang Choon Lee
Emerging PEGylated drugs.
Expert opinion on emerging drugs 2009;14(2):363-80.
2009: Hye Won Lee; Hye Young Ji; Hoi Yun Kim; Kang Choon Lee; Hye Suk Lee
Liquid chromatography-tandem mass spectrometry method for the determination of meloxicam and its metabolite 5-carboxymeloxicam in human plasma.
Bioanalysis 2009;1(1):63-70.
2009: Su Young Chae; Young Goo Chun; Seulki Lee; Cheng-Hao Jin; Eun Seong Lee; Kang Choon Lee; Yu Seok Youn
Pharmacokinetic and pharmacodynamic evaluation of site-specific PEGylated glucagon-like peptide-1 analogs as flexible postprandial-glucose controllers.
Journal of pharmaceutical sciences 2009;98(4):1556-67.
2009: Cheng-Hao Jin; Su Young Chae; Sohee Son; Tae Hyung Kim; Key An Um; Yu Seok Youn; Seulki Lee; Kang Choon Lee
A new orally available glucagon-like peptide-1 receptor agonist, biotinylated exendin-4, displays improved hypoglycemic effects in db/db mice.
Journal of controlled release : official journal of the Controlled Release Society 2009;133(3):172-7.
2008: Eun Ji Park; Dong Hee Na; Young-Hee Shin; Kang Choon Lee
Liquid chromatography-mass spectrometric method for the sensitive determination of niflumic acid in human plasma and its application to pharmacokinetic study of talniflumate tablet.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;876(2):159-62.
2008: Seong Ju Na; Su Young Chae; Seulki Lee; Kyeongsoon Park; Kwangmeyung Kim; Jae Hyung Park; Ick Chan Kwon; Seo Young Jeong; Kang Choon Lee
Stability and bioactivity of nanocomplex of TNF-related apoptosis-inducing ligand.
International journal of pharmaceutics 2008;363(1-2):149-54.
2008: Een Jeong Park; Hye Won Lee; Hye Young Ji; Hoe Yoon Kim; Mann Hyung Lee; Eun-Seok Park; Kang Choon Lee; Hye Suk Lee
Hydrophilic interaction chromatography-tandem mass spectrometry of donepezil in human plasma: application to a pharmacokinetic study of donepezil in volunteers.
Archives of pharmacal research 2008;31(9):1205-11.
2008: Sun Woo Jang; Jung Woo Lee; Sung Hyun Park; Jeong Hoon Kim; Moohi Yoo; Dong Hee Na; Kang Choon Lee
Gastroretentive drug delivery system of DA-6034, a new flavonoid derivative, for the treatment of gastritis.
International journal of pharmaceutics 2008;356(1-2):88-94.
2008: Hye Young Ji; Eun Jeong Park; Kang Choon Lee; Hye Suk Lee
Quantification of doxazosin in human plasma using hydrophilic interaction liquid chromatography with tandem mass spectrometry.
Journal of separation science 2008;31(9):1628-33.
2008: Yu Seok Youn; J E Jeon; Su Young Chae; Seulki Lee; Kang Choon Lee
PEGylation improves the hypoglycaemic efficacy of intranasally administered glucagon-like peptide-1 in type 2 diabetic db/db mice.
Diabetes, obesity & metabolism 2008;10(4):343-6.
2008: Yu Seok Youn; Su Young Chae; Seulki Lee; Min Jung Kwon; Han Jong Shin; Kang Choon Lee
Improved peroral delivery of glucagon-like peptide-1 by site-specific biotin modification: design, preparation, and biological evaluation.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;68(3):667-75.
2008: Dong Hee Na; Eun Ji Park; Yeong Woo Jo; Kang Choon Lee
Capillary electrophoretic separation of high-molecular-weight poly(ethylene glycol)-modified proteins.
Analytical biochemistry 2008;373(2):207-12.
2008: Yu Seok Youn; Min Jung Kwon; Dong Hee Na; Su Young Chae; Seulki Lee; Kang Choon Lee
Improved intrapulmonary delivery of site-specific PEGylated salmon calcitonin: optimization by PEG size selection.
Journal of controlled release : official journal of the Controlled Release Society 2008;125(1):68-75.
2008: Meltem Cetin; Yu Seok Youn; Yilmaz Capan; Kang Choon Lee
Preparation and characterization of salmon calcitonin-biotin conjugates.
AAPS PharmSciTech 2008;9(4):1191-7.
2008: Su Young Chae; Cheng-Hao Jin; Han Jong Shin; Yu Seok Youn; Seulki Lee; Kang Choon Lee
Preparation, characterization, and application of biotinylated and biotin-PEGylated glucagon-like peptide-1 analogues for enhanced oral delivery.
Bioconjugate chemistry 2008;19(1):334-41.
2007: Eun Ji Park; Dong Hee Na; Kang Choon Lee
In vitro release study of mono-PEGylated growth hormone-releasing peptide-6 from PLGA microspheres.
International journal of pharmaceutics 2007;343(1-2):281-3.
2007: Dong Won Jeong; Young Hoon Kim; Hye Young Ji; Yu Seok Youn; Kang Choon Lee; Hye Suk Lee
Analysis of carvedilol in human plasma using hydrophilic interaction liquid chromatography with tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis 2007;44(2):547-52.
2007: Yu Seok Youn; Min Jae Shin; Su Young Chae; Cheng-Hao Jin; Tae Hyung Kim; Kang Choon Lee
Biological and physicochemical evaluation of the conformational stability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Biotechnology letters 2007;29(5):713-21.
2007: Beom Soo Shin; Chul Hwan Kim; Min-Nyung Lee; Man-Wook Hur; Kang Choon Lee; Yu Seok Youn; Sun Dong Yoo
Pharmacokinetics of 125I-GST-TatdMt, a recombinant fusion protein possessing potent anti-obesity activity, after intravenous, nasal, oral, and subcutaneous administration.
Regulatory peptides 2007;140(1-2):74-80.
2007: Yu Seok Youn; Kang Choon Lee
Site-specific PEGylation for high-yield preparation of Lys(21)-amine PEGylated growth hormone-releasing factor (GRF) (1-29) using a GRF(1-29) derivative FMOC-protected at Tyr(1) and Lys(12).
Bioconjugate chemistry 2007;18(2):500-6.
2007: Yu Seok Youn; Dong Hee Na; Kang Choon Lee
High-yield production of biologically active mono-PEGylated salmon calcitonin by site-specific PEGylation.
Journal of controlled release : official journal of the Controlled Release Society 2007;117(3):371-9.
2007: Dong Hee Na; Jeong Eun Lee; Sun Woo Jang; Kang Choon Lee
Formation of acylated growth hormone-releasing peptide-6 by poly(lactide-co-glycolide) and its biological activity.
AAPS PharmSciTech 2007;8(2):Article 43.
2007: Yu Seok Youn; Su Young Chae; Seulki Lee; Jae Eun Jeon; Hyong Goo Shin; Kang Choon Lee
Evaluation of therapeutic potentials of site-specific PEGylated glucagon-like peptide-1 isomers as a type 2 anti-diabetic treatment: Insulinotropic activity, glucose-stabilizing capability, and proteolytic stability.
Biochemical pharmacology 2007;73(1):84-93.
2006: Yu Seok Youn; Ju Young Jung; Seung Hyun Oh; Sun Dong Yoo; Kang Choon Lee
Improved intestinal delivery of salmon calcitonin by Lys18-amine specific PEGylation: stability, permeability, pharmacokinetic behavior and in vivo hypocalcemic efficacy.
Journal of controlled release : official journal of the Controlled Release Society 2006;114(3):334-42.
2006: Beom Soo Shin; Hyun Sook Chang; Eun Hye Park; Chi Ho Yoon; Hye Youn Kim; John Kim; Jae Kuk Ryu; Ok Pyo Zee; Kang Choon Lee; Dianxiu Cao; Sun Dong Yoo
Pharmacokinetics of a novel histone deacetylase inhibitor, apicidin, in rats.
Biopharmaceutics & drug disposition 2006;27(2):69-75.
2006: Yeong Woo Jo; Yu Seok Youn; Sung Hee Lee; Byong-Moon Kim; Soo Hyung Kang; Moohi Yoo; Eung-Chil Choi; Kang Choon Lee
Long-acting interferon-alpha 2a modified with a trimer-structured polyethylene glycol: preparation, in vitro bioactivity, in vivo stability and pharmacokinetics.
International journal of pharmaceutics 2006;309(1-2):87-93.
2006: Chi Ho Yoon; Soo Jin Kim; Beom Soo Shin; Kang Choon Lee; Sun Dong Yoo
Rapid screening of blood-brain barrier penetration of drugs using the immobilized artificial membrane phosphatidylcholine column chromatography.
Journal of biomolecular screening 2006;11(1):13-20.
2006: Hye Young Ji; Dong Won Jeong; Young Hoon Kim; Hui-Hyun Kim; Yoo-Seok Yoon; Kang Choon Lee; Hye Suk Lee
Determination of gabapentin in human plasma using hydrophilic interaction liquid chromatography with tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2006;20(14):2127-32.
2005: Sung Ok Lee; Sang Zin Choi; Sang Un Choi; Kang Choon Lee; Young-Won Chin; Jinwoong Kim; Young Choong Kim; Kang Ro Lee
Labdane diterpenes from Aster spathulifolius and their cytotoxic effects on human cancer cell lines.
Journal of natural products 2005;68(10):1471-4.
2005: Chul Soon Yong; Yu-Kyoung Oh; Yong-Il Kim; JONG OH KIM; Bong Kyu Yoo; Jong-Dal Rhee; Kang Choon Lee; Dae-Duk Kim; Young-Joon Park; Chong-Kook Kim; Han-Gon Choi
Physicochemical characterization and in vivo evaluation of poloxamer-based solid suppository containing diclofenac sodium in rats.
International journal of pharmaceutics 2005;301(1-2):54-61.
2005: Beom Soo Shin; Chul Hwan Kim; Yoon Sik Jun; Eun Hye Park; Man-Wook Hur; Kang Choon Lee; Yu Seok Yoon; Min-Nyung Lee; Sun Dong Yoo
Dose-linear pharmacokinetics, tissue distribution, and excretion of a recombinant fusion protein 125I-GST-TatdMt possessing potent anti-obesity activity.
Regulatory peptides 2005;129(1-3):25-30.
2005: In-Sook Kim; Soo-Kyung Lee; Yu-Mi Park; Yong-Bok Lee; Sang-Chul Shin; Kang Choon Lee; In-Joon Oh
Physicochemical characterization of poly(L-lactic acid) and poly(D,L-lactide-co-glycolide) nanoparticles with polyethylenimine as gene delivery carrier.
International journal of pharmaceutics 2005;298(1):255-62.
2005: Yu Seok Youn; Dong Hee Na; Sun Dong Yoo; Soo-Chang Song; Kang Choon Lee
Carbohydrate-specifically polyethylene glycol-modified ricin A-chain with improved therapeutic potential.
The international journal of biochemistry & cell biology 2005;37(7):1525-33.
2005: Kyung Man Lee; In Sook Kim; Yong-Bok Lee; Sang-Chul Shin; Kang Choon Lee; In-Joon Oh
Evaluation of transferrin-polyethylenimine conjugate for targeted gene delivery.
Archives of pharmacal research 2005;28(6):722-9.
2005: Dong Hee Na; Kang Choon Lee; Patrick P DeLuca
PEGylation of octreotide: II. Effect of N-terminal mono-PEGylation on biological activity and pharmacokinetics.
Pharmaceutical research 2005;22(5):743-9.
2005: Sang-Heon Lee; Seulki Lee; Yu Seok Youn; Dong Hee Na; Su Young Chae; Youngro Byun; Kang Choon Lee
Synthesis, characterization, and pharmacokinetic studies of PEGylated glucagon-like peptide-1.
Bioconjugate chemistry 2005;16(2):377-82.
2005: Saffar Mansoor; Yu Seok Youn; Kang Choon Lee
Oral delivery of mono-PEGylated sCT (Lys18) in rats: regional difference in stability and hypocalcemic effect.
Pharmaceutical development and technology 2005;10(3):389-96.
2004: Yu Seok Youn; Dong Hee Na; Sun Dong Yoo; Soo-Chang Song; Kang Choon Lee
Chromatographic separation and mass spectrometric identification of positional isomers of polyethylene glycol-modified growth hormone-releasing factor (1-29).
Journal of chromatography. A 2004;1061(1):45-9.
2004: Beom Soo Shin; Chul Hwan Kim; Yoon Sik Jun; Dong Hwan Kim; Byung Mu Lee; Chi Ho Yoon; Eun Hye Park; Kang Choon Lee; Soon-Young Han; Kui Lea Park; Hyung Sik Kim; Sun Dong Yoo
Physiologically based pharmacokinetics of bisphenol A.
Journal of toxicology and environmental health. Part A 2004;67(23-24):1971-85.
2004: Kyu Ha Lee; Yong Deuk Min; Sang Zin Choi; Hak Cheol Kwon; Ock Ryun Cho; Kang Choon Lee; Kang Ro Lee
A new sesquiterpene lactone from Artemisia rubripes nakai.
Archives of pharmacal research 2004;27(10):1016-9.
2004: Beom Soo Shin; Chul Hwan Kim; Yoon Sik Jun; Chi Ho Yoon; Jae Il Rho; Kang Choon Lee; Hye Seon Han; Sun Dong Yoo
Oral absorption and pharmacokinetics of rebamipide and rebamipide lysinate in rats.
Drug development and industrial pharmacy 2004;30(8):869-76.
2004: Dong Hee Na; Kang Choon Lee
Capillary electrophoretic characterization of PEGylated human parathyroid hormone with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Analytical biochemistry 2004;331(2):322-8.
2004: Beom Soo Shin; Ji Hoon Jung; Kang Choon Lee; Sun Dong Yoo
Nasal absorption and pharmacokinetic disposition of salmon calcitonin modified with low molecular weight polyethylene glycol.
Chemical & pharmaceutical bulletin 2004;52(8):957-60.
2004: Dong Hee Na; Patrick P DeLuca; Kang Choon Lee
Direct determination of the peptide content in microspheres by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Analytical chemistry 2004;76(9):2669-73.
2004: Dong Hee Na; Cheong Kwan Cho; Yu Seok Youn; Youngju Choi; Kang Ro Lee; Sun Dong Yoo; Kang Choon Lee
Capillary electrophoresis to characterize ricin and its subunits with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Toxicon : official journal of the International Society on Toxinology 2004;43(3):329-35.
2004: Dong Hee Na; Yu Seok Youn; Eun Ji Park; Jeong Min Lee; Ock Ryun Cho; Kang Ro Lee; Sang Deuk Lee; Sun Dong Yoo; Patrick P DeLuca; Kang Choon Lee
Stability of PEGylated salmon calcitonin in nasal mucosa.
Journal of pharmaceutical sciences 2004;93(2):256-61.
2004: Keun-Hong Park; Kun Na; Kang Choon Lee
Immobilization of Arg-Gly-Asp (RGD) sequence in sugar containing copolymer for culturing of pheochromocytoma (PC12) cells.
Journal of bioscience and bioengineering 2004;97(3):207-11.
2004: Dong Hee Na; Yu Seok Youn; Kang Choon Lee
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for monitoring and optimization of site-specific PEGylation of ricin A-chain.
Rapid communications in mass spectrometry : RCM 2004;18(18):2185-9.
2003: Dong Hee Na; Santos B Murty; Kang Choon Lee; BC Thanoo; Patrick P DeLuca
Preparation and stability of poly(ethylene glycol) (PEG)ylated octreotide for application to microsphere delivery.
AAPS PharmSciTech 2003;4(4):E72.
2003: Kang Choon Lee; MO Park; Dong Hee Na; Yu Seok Youn; S D Lee; Sun Dong Yoo; HS Lee; Patrick P DeLuca
Intranasal delivery of PEGylated salmon calcitonins: hypocalcemic effects in rats.
Calcified tissue international 2003;73(6):545-9.
2003: Dong Hee Na; Yu Seok Youn; Sang Deuk Lee; Mi-Won Son; Won Bae Kim; Patrick P DeLuca; Kang Choon Lee
Monitoring of peptide acylation inside degrading PLGA microspheres by capillary electrophoresis and MALDI-TOF mass spectrometry.
Journal of controlled release : official journal of the Controlled Release Society 2003;92(3):291-9.
2003: Keun-Hong Park; Toshihiro Akaike; Kang Choon Lee
Visualization of specific interaction between biomimetic glycopolymer containing reducing glucose moiety and HepG2 cell mediated by GLUT-1.
Journal of biomedical materials research. Part A 2003;65(2):136-43.
2003: Hak Cheol Kwon; Kang Choon Lee; Ock Ryun Cho; I Yeon Jung; Sae Yun Cho; Sun Yeou Kim; Kang Ro Lee
Sphingolipids from Bombycis Corpus 101A and their neurotrophic effects.
Journal of natural products 2003;66(4):466-9.
2003: Kun Na; Dongchul Shin; Kyusik Yun; Keun-Hong Park; Kang Choon Lee
Conjugation of heparin into carboxylated pullulan derivatives as an extracellular matrix for endothelial cell culture.
Biotechnology letters 2003;25(5):381-5.
2003: Hak Cheol Kwon; Ock Ryun Cho; Kang Choon Lee; Kang Ro Lee
Cerebrosides and terpene glycosides from the root of Aster scaber.
Archives of pharmacal research 2003;26(2):132-7.
2003: Dong Hee Na; Yu Seok Youn; Kang Choon Lee
Optimization of the PEGylation process of a peptide by monitoring with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Rapid communications in mass spectrometry : RCM 2003;17(19):2241-4.
2002: Won Bin Lee; Hak Cheol Kwon; Ock Ryun Cho; Kang Choon Lee; Sang Un Choi; Nam-In Baek; Kang Ro Lee
Phytochemical constituents of Cirsium setidens Nakai and their cytotoxicity against human cancer cell lines.
Archives of pharmacal research 2002;25(5):628-35.
2002: Chang Youn Cho; Beom Soo Shin; Ji Hoon Jung; Dong Hwan Kim; Kang Choon Lee; Soon-Young Han; Hyung Sik Kim; Byung Mu Lee; Sun Dong Yoo
Pharmacokinetic scaling of bisphenol A by species-invariant time methods.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(10):925-34.
2002: Sun Dong Yoo; Eunhee Kang; Beom Soo Shin; Hun Jun; Sang-Heon Lee; Kang Choon Lee; Kyu-Hyun Lee
Interspecies comparison of the oral absorption of itraconazole in laboratory animals.
Archives of pharmacal research 2002;25(3):387-91.
2002: Keun-Hong Park; Kun Na; Toshihiro Akaike; Kang Choon Lee
Probe of specific interaction between a simplified synthetic glycopolymer and erythrocytes as mediated by a glucose transporter (GLUT) on a cell membrane.
Journal of biomedical materials research 2002;59(3):591-4.
2002: Beom Soo Shin; Sun Dong Yoo; Chang Youn Cho; Ji Hoon Jung; Byung Mu Lee; Jung Ha Kim; Kang Choon Lee; Soon-Young Han; Hyung Sik Kim; Kui Lea Park
Maternal-fetal disposition of bisphenol a in pregnant Sprague-Dawley rats.
Journal of toxicology and environmental health. Part A 2002;65(5-6):395-406.
2001: Sun Dong Yoo; Beom Soo Shin; Byung Mu Lee; Kang Choon Lee; Soon-Young Han; Hyung Sik Kim; Seung Jun Kwack; Kui Lea Park
Bioavailability and mammary excretion of bisphenol a in Sprague-Dawley rats.
Journal of toxicology and environmental health. Part A 2001;64(5):417-26.
2001: Sung Jin Choi; HY Lee; SB Kim; JH Kim; S S Lee; Sun Dong Yoo; Kang Choon Lee; Ho Sub Lee
Determination of growth hormone-releasing hexapeptide by reversed-phase high-performance liquid chromatography with electrochemical detection.
Journal of chromatography. B, Biomedical sciences and applications 2001;754(2):461-6.
2001: Dong Hee Na; MO Park; S Y Choi; Y S Kim; S S Lee; Sun Dong Yoo; HS Lee; Kang Choon Lee
Identification of the modifying sites of mono-PEGylated salmon calcitonins by capillary electrophoresis and MALDI-TOF mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 2001;754(1):259-63.
2001: S J Choi; S B Kim; H Y Lee; D H Na; Y S Yoon; S S Lee; JH Kim; Kang Choon Lee; Ho Sub Lee
Column-switching high-performance liquid chromatographic determination of clarithromycin in human plasma with electrochemical detection.
Talanta 2001;54(2):377-82.
2001: Byung Ho Woo; JT Lee; Dong Hee Na; Kang Choon Lee
Sepharose-unbinding ricin E as a source for ricin A chain immunotoxin.
Journal of immunological methods 2001;249(1-2):91-8.
2000: Sun Dong Yoo; Hun Jun; Beom Soo Shin; HS Lee; MO Park; Patrick P DeLuca; Kang Choon Lee
Pharmacokinetic disposition of polyethylene glycol-modified salmon calcitonins in rats.
Chemical & pharmaceutical bulletin 2000;48(12):1921-4.
2000: Sun Dong Yoo; Eunhee Kang; Hun Jun; Beom Soo Shin; Kang Choon Lee; Kyu-Hyun Lee
Absorption, first-pass metabolism, and disposition of itraconazole in rats.
Chemical & pharmaceutical bulletin 2000;48(6):798-801.
1999: Sun Dong Yoo; B M Yoon; H S Lee; Kang Choon Lee
Increased bioavailability of clomipramine after sublingual administration in rats.
Journal of pharmaceutical sciences 1999;88(11):1119-21.
1999: Byung Ho Woo; JT Lee; MO Park; Kang Ro Lee; J W Han; E S Park; Sun Dong Yoo; Kang Choon Lee
Stability and cytotoxicity of Fab-ricin A immunotoxins prepared with water soluble long chain heterobifunctional crosslinking agents.
Archives of pharmacal research 1999;22(5):459-63.
1999: Kang Choon Lee; S C Moon; MO Park; JT Lee; Dong Hee Na; Sun Dong Yoo; HS Lee; Patrick P DeLuca
Isolation, characterization, and stability of positional isomers of mono-PEGylated salmon calcitonins.
Pharmaceutical research 1999;16(6):813-8.
1999: Kang Choon Lee; K K Tak; MO Park; JT Lee; Byung Ho Woo; Sun Dong Yoo; HS Lee; Patrick P DeLuca
Preparation and characterization of polyethylene-glycol-modified salmon calcitonins.
Pharmaceutical development and technology 1999;4(2):269-75.
1999: H M Lee; Sung Jin Choi; CK Jeong; Y S Kim; Kang Choon Lee; Ho Sub Lee
Microbore high-performance liquid chromatographic determination of cisapride in rat serum samples using column switching.
Journal of chromatography. B, Biomedical sciences and applications 1999;727(1-2):213-7.
1999: Ho Sub Lee; Y S Kim; SB Kim; B E Choi; B H Woo; Kang Choon Lee
Isolation and characterization of biologically active lectin from Korean mistletoe, Viscum album var. Coloratum.
Cellular and molecular life sciences : CMLS 1999;55(4):679-82.
1999: Dong Hee Na; Byung Ho Woo; Kang Choon Lee
Quantitative analysis of derivatized proteins prepared with pyridyl disulfide-containing cross-linkers by high-performance liquid chromatography.
Bioconjugate chemistry 1999;10(2):306-10.
1998: Byung Ho Woo; JT Lee; Kang Choon Lee
Purification of Sepharose-unbinding ricin from castor beans (Ricinus communis) by hydroxyapatite chromatography.
Protein expression and purification 1998;13(2):150-4.
1997: S W Jang; Byung Ho Woo; JT Lee; S C Moon; Kang Choon Lee; Patrick P DeLuca
Stability of Octastatin, a somatostatin analog cyclic octapeptide, in aqueous solution.
Pharmaceutical development and technology 1997;2(4):409-14.
1997: Kang Choon Lee; T S Kang; Byung Ho Woo; JT Lee; H S Lee; Patrick P DeLuca
Reversed-phase high-performance liquid chromatography of radioiodinated salmon calcitonins.
Journal of chromatography. B, Biomedical sciences and applications 1997;694(1):31-7.
1994: Byung Ho Woo; JT Lee; Kang Choon Lee
Ricin A immunotoxins of IgG and Fab of anti-CALLA monoclonal antibody: effect of water soluble long-chain SPDP on conjugate yield, immunoselectivity and cytotoxicity.
Archives of pharmacal research 1994;17(6):452-7.