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Kuo-Hsiung Lee
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83
Bastow, Kenneth
41
Morris-Natschke, Susan
33
Kashiwada, Yoshiki
27
Fukamiya, Narihiko
25
Cheng, Yung-Chi
25
Okano, Masayoshi
24
Kuo, Sheng-Chu
24
Wang, Hui-Kang
21
Tagahara, Kiyoshi
20
Cosentino, Mark
19
Chang, Fang-Rong
18
Hamel, Ernest
17
Brossi, Arnold
17
Nakagawa-Goto, Kyoko
17
Wu, Tian-Shung
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All Publications
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2009: Chen Chun-Jen; Wen Yen-Fang; Huang Pi-Tsan; Hsu Mei-Hua; Lee Kuo-Hsiung; Chen Mei-Hwai; Shin Wuu-Chian; Huang Li-Jiau; Kuo Sheng-Chu
2-(1-Hydroxethyl)-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione (BTP-11) enhances the ATRA-induced differentiation in human leukemia HL-60 cells.
Leukemia research 2009;33(12):1664-9.
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2009: Dong Yizhou; Shi Qian; Nakagawa-Goto Kyoko; Wu Pei-Chi; Bastow Kenneth F; Morris-Natschke Susan L; Lee Kuo-Hsiung
Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.
Bioorganic & medicinal chemistry letters 2009;19(22):6289-92.
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2009: Kuo Reen-Yen; Qian Keduo; Morris-Natschke Susan L; Lee Kuo-Hsiung
Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents.
Natural product reports 2009;26(10):1321-44.
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2009: Tian Xingtao; Qin Bingjie; Lu Hong; Lai Weihong; Jiang Shibo; Lee Kuo-Hsiung; Chen Chin Ho; Xie Lan
Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(18):5482-5.
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2009: Chang Yu-Hsun; Hsu Mei-Hua; Wang Sheng-Hung; Huang Li-Jiau; Qian Keduo; Morris-Natschke Susan L; Hamel Ernest; Kuo Sheng-Chu; Lee Kuo-Hsiung
Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly.
Journal of medicinal chemistry 2009;52(15):4883-91.
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2009: Su Chung-Ren; Yeh Sheau Farn; Liu Chih Miem; Damu Amooru G; Kuo Tsung-Hsiao; Chiang Po-Cheng; Bastow Kenneth F; Lee Kuo-Hsiung; Wu Tian-Shung
Anti-HBV and cytotoxic activities of pyranocoumarin derivatives.
Bioorganic & medicinal chemistry 2009;17(16):6137-43.
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2009: Huang Fei; Zhao Ming; Zhang Xiaoyi; Wang Chao; Qian Keduo; Kuo Reen-Yen; Morris-Natschke Susan; Lee Kuo-Hsiung; Peng Shiqi
Synthesis, DNA intercalation and 3D QSAR analysis of cis-2,4,5-trisubstituted-1,3-dithiolanes as a novel class of antitumor agents.
Bioorganic & medicinal chemistry 2009;17(16):6085-95.
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2009: Nakagawa-Goto Kyoko; Yamada Koji; Taniguchi Masahiko; Tokuda Harukuni; Lee Kuo-Hsiung
Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents.
Bioorganic & medicinal chemistry letters 2009;19(13):3378-81.
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2009: Dong Yizhou; Shi Qian; Liu Yi-Nan; Wang Xiang; Bastow Kenneth F; Lee Kuo-Hsiung
Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents.
Journal of medicinal chemistry 2009;52(11):3586-90.
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2009: Qian Keduo; Yu Donglei; Chen Chin-Ho; Huang Li; Morris-Natschke Susan L; Nitz Theodore J; Salzwedel Karl; Reddick Mary; Allaway Graham P; Lee Kuo-Hsiung
Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents.
Journal of medicinal chemistry 2009;52(10):3248-58.
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2009: Qian Keduo; Morris-Natschke Susan L; Lee Kuo-Hsiung
HIV entry inhibitors and their potential in HIV therapy.
Medicinal research reviews 2009;29(2):369-93.
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2008: Wu Gang; Guo Huan-Fang; Gao Kun; Liu Yi-Nan; Bastow Kenneth F; Morris-Natschke Susan L; Lee Kuo-Hsiung; Xie Lan
Synthesis of unsymmetrical biphenyls as potent cytotoxic agents.
Bioorganic & medicinal chemistry letters 2008;18(19):5272-6.
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2008: Lee Chia-Lin; Nakagawa-Goto Kyoko; Yu Donglei; Liu Yi-Nan; Bastow Kenneth F; Morris-Natschke Susan L; Chang Fang-Rong; Wu Yang-Chang; Lee Kuo-Hsiung
Cytotoxic calanquinone A from Calanthe arisanensis and its first total synthesis.
Bioorganic & medicinal chemistry letters 2008;18(15):4275-7.
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2008: Reddy M Vijaya Bhaskar; Su Chung-Ren; Chiou Wen-Fei; Liu Yi-Nan; Chen Rosemary Yin-Hwa; Bastow Kenneth F; Lee Kuo-Hsiung; Wu Tian-Shung
Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents.
Bioorganic & medicinal chemistry 2008;16(15):7358-70.
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2008: Huang Li; Yu Donglei; Ho Phong; Qian Keduo; Lee Kuo-Hsiung; Chen Chin-Ho
Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives.
Bioorganic & medicinal chemistry 2008;16(14):6696-701.
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2008: Itokawa Hideji; Morris-Natschke Susan L; Akiyama Toshiyuki; Lee Kuo-Hsiung
Plant-derived natural product research aimed at new drug discovery.
Journal of natural medicines 2008;62(3):263-80.
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2008: Chen Yu; Cui Guohui; Zhao Ming; Wang Chao; Qian Keduo; Morris-Natschke Susan; Lee Kuo-Hsiung; Peng Shiqi
Synthesis, nano-scale assembly, and in vivo anti-thrombotic activity of novel short peptides containing L-Arg and L-Asp or L-Glu.
Bioorganic & medicinal chemistry 2008;16(11):5914-25.
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2008: Nakagawa-Goto Kyoko; Bastow Kenneth F; Chen Tzu-Hsuan; Morris-Natschke Susan L; Lee Kuo-Hsiung
Antitumor agents 260. New desmosdumotin B analogues with improved in vitro anticancer activity.
Journal of medicinal chemistry 2008;51(11):3297-303.
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2008: Su Chung-Ren; Damu Amooru G; Chiang Po-Cheng; Bastow Kenneth F; Morris-Natschke Susan L; Lee Kuo-Hsiung; Wu Tian-Shung
Total synthesis of phenanthroindolizidine alkaloids (+/-)-antofine, (+/-)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity.
Bioorganic & medicinal chemistry 2008;16(11):6233-41.
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2008: Peng Chieh-Yu; Pan Shiow-Lin; Lee Kuo-Hsiung; Bastow Kenneth F; Teng Che-Ming
Molecular mechanism of the inhibitory effect of KS-5 on bFGF-induced angiogenesis in vitro and in vivo.
Cancer letters 2008;263(1):114-21.
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2008: Lin An-Shen; Qian Keduo; Usami Yoshihide; Lin Li; Itokawa Hideji; Hsu Charleson; Morris-Natschke Susan L; Lee Kuo-Hsiung
5-Hydroxymethyl-2-furfural, a clinical trials agent for sickle cell anemia, and its mono/di-glucosides from classically processed steamed Rehmanniae Radix.
Journal of natural medicines 2008;62(2):164-7.
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2008: Usami Yoshihide; Liu Yi-Nan; Lin An-Shen; Shibano Makio; Akiyama Toshiyuki; Itokawa Hideji; Morris-Natschke Susan L; Bastow Kenneth; Kasai Ryoji; Lee Kuo-Hsiung
Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)H NMR spectra.
Journal of natural products 2008;71(3):478-81.
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2008: Wang Shih-Wei; Pan Shiow-Lin; Huang Yu-Chun; Guh Jih-Hwa; Chiang Po-Cheng; Huang Der-Yi; Kuo Sheng-Chu; Lee Kuo-Hsiung; Teng Che-Ming
CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo.
Molecular cancer therapeutics 2008;7(2):350-60.
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2008: Gao Wenli; Chen Annie Pei-Chun; Leung Chung-Hang; Gullen Elizabeth A; Fürstner Alois; Shi Qian; Wei Linyi; Lee Kuo-Hsiung; Cheng Yung-Chi
Structural analogs of tylophora alkaloids may not be functional analogs.
Bioorganic & medicinal chemistry letters 2008;18(2):704-9.
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2008: Lee Chia-Lin; Chang Fang-Rong; Hsieh Pei-Wen; Chiang Michael-Y; Wu Chin-Chung; Huang Zih-You; Lan Yu-Hsuan; Chen Mei; Lee Kuo-Hsiung; Yen Hsin-Fu; Hung Wen-Chun; Wu Yang-Chang
Cytotoxic ent-abietane diterpenes from Gelonium aequoreum.
Phytochemistry 2008;69(1):276-87.
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2008: Itokawa Hideji; Shi Qian; Akiyama Toshiyuki; Morris-Natschke Susan L; Lee Kuo-Hsiung
Recent advances in the investigation of curcuminoids.
Chinese medicine 2008;3():11.
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2007: Kuo Ping-Chung; Shen Yuh-Chiang; Yang Mei-Lin; Wang Su-Hui; Thang Tran Dinh; Dung Nguyen Xuan; Chiang Po-Cheng; Lee Kuo-Hsiung; Lee E-Jian; Wu Tian-Shung
Crotonkinins A and B and related diterpenoids from Croton tonkinensis as anti-inflammatory and antitumor agents.
Journal of natural products 2007;70(12):1906-9.
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2007: Qian Keduo; Nakagawa-Goto Kyoko; Yu Donglei; Morris-Natschke Susan L; Nitz Theodore J; Kilgore Nicole; Allaway Graham P; Lee Kuo-Hsiung
Anti-AIDS agents 73: structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives.
Bioorganic & medicinal chemistry letters 2007;17(23):6553-7.
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2007: Suzuki Madoka; Yu Donglei; Morris-Natschke Susan L; Smith Philip C; Lee Kuo-Hsiung
Anti-AIDS agents 66: syntheses and anti-HIV activity of phenolic and aza 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) derivatives.
Bioorganic & medicinal chemistry 2007;15(21):6852-8.
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2007: Wang Shih-Wei; Pan Shiow-Lin; Peng Chieh-Yu; Huang Der-Yi; Tsai An-Chi; Chang Ya-Ling; Guh Jih-Hwa; Kuo Sheng-Chu; Lee Kuo-Hsiung; Teng Che-Ming
CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression.
Cancer letters 2007;257(1):87-96.
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2007: Shibano Makio; Lin An-Shen; Itokawa Hideji; Lee Kuo-Hsiung
Separation and characterization of active flavonolignans of Silybum marianum by liquid chromatography connected with hybrid ion-trap and time-of-flight mass spectrometry (LC-MS/IT-TOF).
Journal of natural products 2007;70(9):1424-8.
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2007: Nakagawa-Goto Kyoko; Yamada Koji; Nakamura Seikou; Chen Tzu-Hsuan; Chiang Po-Cheng; Bastow Kenneth F; Wang Shao-Chun; Spohn Bill; Hung Mien-Chie; Lee Fang-Yu; Lee Fang-Chen; Lee Kuo-Hsiung
Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant--taxoid conjugates as novel cytotoxic agents.
Bioorganic & medicinal chemistry letters 2007;17(18):5204-9.
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2007: Tatsuzaki Jin; Taniguchi Masahiko; Bastow Kenneth F; Nakagawa-Goto Kyoko; Morris-Natschke Susan L; Itokawa Hideji; Baba Kimiye; Lee Kuo-Hsiung
Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents.
Bioorganic & medicinal chemistry 2007;15(18):6193-9.
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2007: Wang Qi; Mu Qing; Shibano Makio; Morris-Natschke Susan L; Lee Kuo-Hsiung; Chen Dao-Feng
Eremophilane sesquiterpenes from Ligularia macrophylla.
Journal of natural products 2007;70(8):1259-62.
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2007: Zhou Li-Bo; Chen Tzu-Hsuan; Bastow Kenneth F; Shibano Makio; Lee Kuo-Hsiung; Chen Dao-Feng
Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus.
Journal of natural products 2007;70(8):1263-7.
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2007: Lin An-Shen; Nakagawa-Goto Kyoko; Chang Fang-Rong; Yu Donglei; Morris-Natschke Susan L; Wu Chin-Chung; Chen Shu-Li; Wu Yang-Chang; Lee Kuo-Hsiung
First total synthesis of protoapigenone and its analogues as potent cytotoxic agents.
Journal of medicinal chemistry 2007;50(16):3921-7.
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2007: Wang Yang; Huang Shao-Xu; Xia Peng; Xia Yi; Yang Zheng-Yu; Kilgore Nicole; Morris-Natschke Susan L; Lee Kuo-Hsiung
Anti-AIDS agents 72. Bioisosteres (7-carbon-DCKs) of the potent anti-HIV lead DCK.
Bioorganic & medicinal chemistry letters 2007;17(15):4316-9.
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2007: Wei Linyi; Shi Qian; Bastow Kenneth F; Brossi Arnold; Morris-Natschke Susan L; Nakagawa-Goto Kyoko; Wu Tian-Shung; Pan Shiow-Lin; Teng Che-Ming; Lee Kuo-Hsiung
Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents.
Journal of medicinal chemistry 2007;50(15):3674-80.
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2007: Damu Amooru G; Kuo Ping-Chung; Su Chung-Ren; Kuo Tsung-Hsiao; Chen Tzu-Hsuan; Bastow Kenneth F; Lee Kuo-Hsiung; Wu Tian-Shung
Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata.
Journal of natural products 2007;70(7):1146-52.
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2007: Nakagawa-Goto Kyoko; Chen Tzu-Hsuan; Peng Chieh-Yu; Bastow Kenneth F; Wu Jiu-Hong; Lee Kuo-Hsiung
Antitumor agents 259. Design, syntheses, and structure-activity relationship study of desmosdumotin C analogs.
Journal of medicinal chemistry 2007;50(14):3354-8.
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2007: Nakagawa-Goto Kyoko; Nakamura Seikou; Bastow Kenneth F; Nyarko Alexander; Peng Chieh-Yu; Lee Fang-Yu; Lee Fang-Chen; Lee Kuo-Hsiung
Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents.
Bioorganic & medicinal chemistry letters 2007;17(10):2894-8.
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2007: Wen Yen-Fang; Lee Kuo-Hsiung; Huang Pi-Tsan; Chen Mei-Hwai; Shin Wuu-Chian; Huang Li-Jiau; Hsu Mei-Hua; Chen Chun-Jen; Kuo Sheng-Chu
Cell differentiation enhancement by hydrophilic derivatives of 4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-diones in HL-60 leukemia cells.
Bioorganic & medicinal chemistry letters 2007;17(10):2908-12.
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2007: Rosselli Sergio; Bruno Maurizio; Maggio Antonella; Bellone Gabriella; Chen Tzu-Hsuan; Bastow Kenneth F; Lee Kuo-Hsiung
Cytotoxic activity of some natural and synthetic ent-kauranes.
Journal of natural products 2007;70(3):347-52.
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2007: Wen Zhiming; Martin David E; Bullock Peter; Lee Kuo-Hsiung; Smith Philip C
Glucuronidation of anti-HIV drug candidate bevirimat: identification of human UDP-glucuronosyltransferases and species differences.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(3):440-8.
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2007: Zhang Shuxing; Wei Linyi; Bastow Ken; Zheng Weifan; Brossi Arnold; Lee Kuo-Hsiung; Tropsha Alexander
Antitumor agents 252. Application of validated QSAR models to database mining: discovery of novel tylophorine derivatives as potential anticancer agents.
Journal of computer-aided molecular design 2007;21(1-3):97-112.
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2007: Wang Xihong; Morris-Natschke Susan L; Lee Kuo-Hsiung
New developments in the chemistry and biology of the bioactive constituents of Tanshen.
Medicinal research reviews 2007;27(1):133-48.
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2007: Yu Donglei; Morris-Natschke Susan L; Lee Kuo-Hsiung
New developments in natural products-based anti-AIDS research.
Medicinal research reviews 2007;27(1):108-32.
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2006: Chen Min; Kilgore Nicole; Lee Kuo-Hsiung; Chen Dao-Feng
Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora.
Journal of natural products 2006;69(12):1697-701.
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2006: Okasaka Mamoru; Takaishi Yoshihisa; Kashiwada Yoshiki; Kodzhimatov Olimjon K; Ashurmetov Ozodbek; Lin Ai J; Consentino L Mark; Lee Kuo-Hsiung
Terpenoids from Juniperus polycarpus var. seravschanica.
Phytochemistry 2006;67(24):2635-40.
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2006: Wu Pei-Lin; Hsu Yu-Lin; Wu Tian-Shung; Bastow K F; Lee Kuo-Hsiung
Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis.
Organic letters 2006;8(23):5207-10.
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2006: Tatsuzaki Jin; Bastow Kenneth F; Nakagawa-Goto Kyoko; Nakamura Seiko; Itokawa Hideji; Lee Kuo-Hsiung
Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents.
Journal of natural products 2006;69(10):1445-9.
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2006: Wei Linyi; Brossi Arnold; Kendall Ross; Bastow Kenneth F; Morris-Natschke Susan L; Shi Qian; Lee Kuo-Hsiung
Antitumor agents 251: synthesis, cytotoxic evaluation, and structure-activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents.
Bioorganic & medicinal chemistry 2006;14(19):6560-9.
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2006: Horiuch Masafumi; Murakami Chihiro; Fukamiya Narihiko; Yu Donglei; Chen Tzu-Hsuan; Bastow Kenneth F; Zhang De-Cheng; Takaishi Yoshihisa; Imakura Yasuhiro; Lee Kuo-Hsiung
Tripfordines A-C, sesquiterpene pyridine alkaloids from Tripterygium wilfordii, and structure anti-HIV activity relationships of Tripterygium alkaloids.
Journal of natural products 2006;69(9):1271-4.
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2006: Wang Xihong; Nakagawa-Goto Kyoko; Bastow Kenneth F; Don Ming-Jaw; Lin Yun-Lian; Wu Tian-Shung; Lee Kuo-Hsiung
Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents.
Journal of medicinal chemistry 2006;49(18):5631-4.
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2006: Yu Donglei; Sakurai Yojiro; Chen Chin-Ho; Chang Fang-Rong; Huang Li; Kashiwada Yoshiki; Lee Kuo-Hsiung
Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents.
Journal of medicinal chemistry 2006;49(18):5462-9.
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2006: Wen Zhiming; Stern Stephan T; Martin David E; Lee Kuo-Hsiung; Smith Philip C
Structural characterization of anti-HIV drug candidate PA-457 [3-O-(3',3'-dimethylsuccinyl)-betulinic acid] and its acyl glucuronides in rat bile and evaluation of in vitro stability in human and animal liver microsomes and plasma.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(9):1436-42.
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2006: Kuo Ping-Chung; Kuo Tsung-Hsiao; Damu Amooru G; Su Chung-Ren; Lee E-Jian; Wu Tian-Shung; Shu Rexen; Chen Chou-Ming; Bastow Kenneth F; Chen Tzu-Hsuan; Lee Kuo-Hsiung
Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata.
Organic letters 2006;8(14):2953-6.
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2006: Lin Li; Shi Qian; Nyarko Alexander K; Bastow Kenneth F; Wu Chin-Chung; Su Ching-Yuan; Shih Charles C-Y; Lee Kuo-Hsiung
Antitumor agents. 250. Design and synthesis of new curcumin analogues as potential anti-prostate cancer agents.
Journal of medicinal chemistry 2006;49(13):3963-72.
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2006: Huang Hui-Chi; Tsai Wei-Jern; Morris-Natschke Susan L; Tokuda Harukuni; Lee Kuo-Hsiung; Wu Yang-Chang; Kuo Yao-Haur
Sapinmusaponins F-J, bioactive tirucallane-type saponins from the galls of Sapindus mukorossi.
Journal of natural products 2006;69(5):763-7.
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2006: Sakurai Nobuko; Nakagawa-Goto Kyoko; Ito Junko; Sakurai Yojiro; Nakanishi Yuka; Bastow Kenneth F; Cragg Gordon; Lee Kuo-Hsiung
Cytotoxic Alangium alkaloids from Alangium longiflorum.
Phytochemistry 2006;67(9):894-7.
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2006: Lin Li; Shi Qian; Su Ching-Yuan; Shih Charles C-Y; Lee Kuo-Hsiung
Antitumor agents 247. New 4-ethoxycarbonylethyl curcumin analogs as potential antiandrogenic agents.
Bioorganic & medicinal chemistry 2006;14(8):2527-34.
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2006: Huang Li; Ho Phong; Lee Kuo-Hsiung; Chen Chin-Ho
Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives.
Bioorganic & medicinal chemistry 2006;14(7):2279-89.
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2006: Sakurai Yojiro; Sakurai Nobuko; Taniguchi Masahiko; Nakanishi Yuka; Bastow Kenneth F; Wang Xihong; Cragg Gordon M; Lee Kuo-Hsiung
Rautandiols A and B, pterocarpans and cytotoxic constituents from Neorautanenia mitis.
Journal of natural products 2006;69(3):397-9.
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2006: Chang Fang-Rong; Chen I-Hsiao; Liao Sin-Chung; Issa Hamad H; Hayashi Ken-ichiro; Nozaki Hiroshi; Wu Yang-Chang; Lee Kuo-Hsiung
Three new agarofuran sesquiterpenes reissantins F-H from Reissantia buchananii.
Planta medica 2006;72(1):92-6.
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2005: Bruno Maurizio; Rosselli Sergio; Maggio Antonella; Raccuglia Rosa Angela; Bastow Kenneth F; Wu Chin-Chung; Lee Kuo-Hsiung
Cytotoxic activity of some natural and synthetic sesquiterpene lactones.
Planta medica 2005;71(12):1176-8.
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2005: Xie Lan; Zhao Chun-Hong; Zhou Ting; Chen Hai-Feng; Fan Bo-Tao; Chen Xian-Hong; Ma Jian-Zhou; Li Jing-Yun; Bao Zhuo-Yi; Lo Zhaowen; Yu Donglei; Lee Kuo-Hsiung
Molecular modeling, design, synthesis, and biological evaluation of novel 3',4'-dicamphanoyl-(+)-cis-khellactone (DCK) analogs as potent anti-HIV agents.
Bioorganic & medicinal chemistry 2005;13(23):6435-49.
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2005: Cheng Ming-Jen; Lee Kuo-Hsiung; Tsai Ian-Lih; Chen Ih-Sheng
Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides.
Bioorganic & medicinal chemistry 2005;13(21):5915-20.
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2005: Suzuki Madoka; Li Yutai; Smith Philip C; Swenberg James A; Martin David E; Morris-Natschke Susan L; Lee Kuo-Hsiung
Anti-AIDS agents 65: investigation of the in vitro oxidative metabolism of 3',4'-Di-O-(-)-camphanoyl-(+)-cis-khellactone derivatives as potent anti-hiv agents.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(11):1588-92.
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2005: Liaw Chih-Chuang; Chang Fang-Rong; Chen Shu-Li; Wu Chin-Chung; Lee Kuo-Hsiung; Wu Yang-Chang
Novel cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana.
Bioorganic & medicinal chemistry 2005;13(15):4767-76.
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2005: Bruno Maurizio; Rosselli Sergio; Maggio Antonella; Raccuglia Rosa Angela; Bastow Kenneth F; Lee Kuo-Hsiung
Cytotoxic activity of some natural and synthetic guaianolides.
Journal of natural products 2005;68(7):1042-6.
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2005: Tanaka Naonobu; Okasaka Mamoru; Ishimaru Youko; Takaishi Yoshihisa; Sato Mitsunobu; Okamoto Masato; Oshikawa Tetsuya; Ahmed Sharif Uddin; Consentino L Mark; Lee Kuo-Hsiung
Biyouyanagin A, an anti-HIV agent from Hypericum chinense L. var. salicifolium.
Organic letters 2005;7(14):2997-9.
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2005: Nakamura Seikou; Kozuka Mutsuo; Bastow Kenneth F; Tokuda Harukuni; Nishino Hoyoku; Suzuki Madoka; Tatsuzaki Jin; Morris Natschke Susan L; Kuo Sheng-Chu; Lee Kuo-Hsiung
Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters.
Bioorganic & medicinal chemistry 2005;13(14):4396-401.
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2005: Yu Donglei; Wild Carl T; Martin David E; Morris-Natschke Susan L; Chen Chin-Ho; Allaway Graham P; Lee Kuo-Hsiung
The discovery of a class of novel HIV-1 maturation inhibitors and their potential in the therapy of HIV.
Expert opinion on investigational drugs 2005;14(6):681-93.
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2005: Kuo Yao-Haur; Huang Hui-Chi; Yang Kuo Li-Ming; Hsu Ya-Wen; Lee Kuo-Hsiung; Chang Fang-Rong; Wu Yang-Chang
New dammarane-type saponins from the galls of Sapindus mukorossi.
Journal of agricultural and food chemistry 2005;53(12):4722-7.
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2005: Nakagawa-Goto Kyoko; Bastow Kenneth F; Wu Jiu-Hong; Tokuda Harukuni; Lee Kuo-Hsiung
Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs.
Bioorganic & medicinal chemistry letters 2005;15(12):3016-9.
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2005: Chen Hai-Feng; Fan Bo-Tao; Zhao Chen-Yang; Xie Lan; Zhao Chun-Hong; Zhou Ting; Lee Kuo-Hsiung; Allaway Graham
Computational studies and drug design for HIV-1 reverse transcriptase inhibitors of 3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs.
Journal of computer-aided molecular design 2005;19(4):243-58.
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2005: Zou Zhengrong; Yi Yanghua; Wu Houming; Yao Xinsheng; Du Lijun; Jiuhong Wu; Liaw Chih-Chaung; Lee Kuo-Hsiung
Intercedensides D-I, cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert.
Journal of natural products 2005;68(4):540-6.
-
2005: Wang Hui-Kang; Sakurai Nokuko; Shih Charles Y; Lee Kuo-Hsiung
LC/TIS-MS fingerprint profiling of Cimicifuga species and analysis of 23-Epi-26-deoxyactein in Cimicifuga racemosa commercial products.
Journal of agricultural and food chemistry 2005;53(5):1379-86.
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2005: Fukamiya Narihiko; Lee Kuo-Hsiung; Muhammad Ilias; Murakami Chihiro; Okano Masayohis; Harvey Isabelle; Pelletier Jerry
Structure-activity relationships of quassinoids for eukaryotic protein synthesis.
Cancer letters 2005;220(1):37-48.
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2005: Nakagawa-Goto Kyoko; Wu Jiu-Hong; Bastow Kenneth F; Wu Chin-Chung; Lee Kuo-Hsiung
Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives.
Bioorganic & medicinal chemistry 2005;13(6):2325-30.
-
2005: Huang Li; Yuan Xiong; Yu Donglei; Lee K H; Chen Chin Ho
Mechanism of action and resistant profile of anti-HIV-1 coumarin derivatives.
Virology 2005;332(2):623-8.
-
2005: Sakurai Nobuko; Kozuka Mutsuo; Tokuda Harukuni; Mukainaka Teruo; Enjo Fumio; Nishino Hoyoku; Nagai Masahiro; Sakurai Yojiro; Lee Kuo-Hsiung
Cancer preventive agents. Part 1: chemopreventive potential of cimigenol, cimigenol-3,15-dione, and related compounds.
Bioorganic & medicinal chemistry 2005;13(4):1403-8.
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2005: Wu Pei-Lin; Wu Tian-Shung; He Cai-Xia; Su Chia-Hao; Lee Kuo-Hsiung
Constituents from the stems of Hibiscus taiwanensis.
Chemical & pharmaceutical bulletin 2005;53(1):56-9.
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2005: Kashiwada Yoshiki; Aoshima Akihiro; Ikeshiro Yasumasa; Chen Yuh-Pan; Furukawa Hiroshi; Itoigawa Masataka; Fujioka Toshihiro; Mihashi Kunihide; Cosentino L Mark; Morris-Natschke Susan L; Lee Kuo-Hsiung
Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids.
Bioorganic & medicinal chemistry 2005;13(2):443-8.
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2005: Lai Ya-Yun; Huang Li-Jiau; Lee Kuo-Hsiung; Xiao Zhiyan; Bastow Kenneth F; Yamori Takao; Kuo Sheng-Chu
Synthesis and biological relationships of 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents.
Bioorganic & medicinal chemistry 2005;13(1):265-75.
-
2005: Nakagawa-Goto Kyoko; Chen Cyril X; Hamel Ernest; Wu Chin-Chung; Bastow Kenneth F; Brossi Arnold; Lee Kuo-Hsiung
Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives.
Bioorganic & medicinal chemistry letters 2005;15(1):235-8.
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2004: Chen Ying; Zhang Qian; Zhang Beina; Xia Peng; Xia Yi; Yang Zheng-Yu; Kilgore Nicole; Wild Carl; Morris-Natschke Susan L; Lee Kuo-Hsiung
Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (7-thia-DCK) analogs.
Bioorganic & medicinal chemistry 2004;12(24):6383-7.
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2004: Zhang Qian; Chen Ying; Xia Peng; Xia Yi; Yang Zheng-Yu; Yu Donglei; Morris-Natschke Susan L; Lee Kuo-Hsiung
Anti-AIDS agents. Part 62: anti-HIV activity of 2'-substituted 4-methyl-3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (4-methyl DCK) analogs.
Bioorganic & medicinal chemistry letters 2004;14(23):5855-7.
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2004: Kashiwada Yoshiki; Sekiya Michiko; Ikeshiro Yasumasa; Fujioka Toshihiro; Kilgore Nicole R; Wild Carl T; Allaway Graham P; Lee Kuo-Hsiung
3-O-Glutaryl-dihydrobetulin and related monoacyl derivatives as potent anti-HIV agents.
Bioorganic & medicinal chemistry letters 2004;14(23):5851-3.
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2004: Kawaguchi Yousuke; Ochi Toshimasa; Takaishi Yoshihisa; Kawazoe Kazuyoshi; Lee Kuo-Hsiung
New sesquiterpenes from Capsicum annuum.
Journal of natural products 2004;67(11):1893-6.
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2004: Tanaka Naonobu; Takaishi Yoshihisa; Shikishima Yasuhiro; Nakanishi Yuka; Bastow Kenneth; Lee Kuo-Hsiung; Honda Gisho; Ito Michiho; Takeda Yoshio; Kodzhimatov Olimjon K; Ashurmetov Ozodbek
Prenylated benzophenones and xanthones from Hypericum scabrum.
Journal of natural products 2004;67(11):1870-5.
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2004: Liaw Chih-Chuang; Chang Fang-Rong; Wu Yang-Chang; Wang Hui-Kang; Nakanishi Yuka; Bastow Kenneth F; Lee Kuo-Hsiung
Montacin and cis-montacin, two new cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona montana.
Journal of natural products 2004;67(11):1804-8.
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2004: Wang Xihong; Bastow Kenneth F; Sun Chang-Ming; Lin Yun-Lian; Yu Hsi-Jung; Don Ming-Jaw; Wu Tian-Shung; Nakamura Seikou; Lee Kuo-Hsiung
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
Journal of medicinal chemistry 2004;47(23):5816-9.
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2004: Liaw Chih-Chuang; Chang Fang-Rong; Wu Chin-Chung; Chen Shu-Li; Bastow Kenneth F; Hayashi Ken-ichiro; Nozaki Hiroshi; Lee Kuo-Hsiung; Wu Yang-Chang
Nine new cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana.
Planta medica 2004;70(10):948-59.
-
2004: Xiao Zhiyan; Bastow Kenneth F; Vance John R; Sidwell Robert S; Wang Hui-Kang; Chen Ming S; Shi Qian; Lee Kuo-Hsiung
Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives.
Journal of medicinal chemistry 2004;47(21):5140-8.
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2004: Murakami Chihiro; Fukamiya Narihiko; Tamura Sadaaki; Okano Masayoshi; Bastow Kenneth F; Tokuda Harukuni; Mukainaka Teruo; Nishino Hoyoky; Lee Kuo-Hsiung
Multidrug-resistant cancer cell susceptibility to cytotoxic quassinoids, and cancer chemopreventive effects of quassinoids and canthin alkaloids.
Bioorganic & medicinal chemistry 2004;12(18):4963-8.
-
2004: Zhu Xiao-Kang; Guan Jian; Xiao Zhiyan; Cosentino L Mark; Lee Kuo-Hsiung
Anti-AIDS agents. Part 61: Anti-HIV activity of new podophyllotoxin derivatives.
Bioorganic & medicinal chemistry 2004;12(15):4267-73.
-
2004: Tanaka Naonobu; Ooba Nobuyuki; Duan Hongquan; Takaishi Yoshihisa; Nakanishi Yuka; Bastow Kenneth; Lee Kuo-Hsiung
Kaurane and abietane diterpenoids from Tripterygium doianum (Celastraceae).
Phytochemistry 2004;65(14):2071-6.
-
2004: Hsieh Pei-Wen; Chang Fang-Rong; Lee Kuo-Hsiung; Hwang Tsong-Long; Chang Sue-Ming; Wu Yang-Chang
A new anti-HIV alkaloid, drymaritin, and a new C-glycoside flavonoid, diandraflavone, from Drymaria diandra.
Journal of natural products 2004;67(7):1175-7.
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2004: Yu Donglei; Chen Chin-Ho; Brossi Arnold; Lee Kuo-Hsiung
Anti-AIDS agents. 60. Substituted 3'R,4'R-di-O-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP) analogues as potent anti-HIV agents.
Journal of medicinal chemistry 2004;47(16):4072-82.
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2004: Hayashi Ken-ichiro; Chang Fang-Rong; Nakanishi Yuka; Bastow Kenneth F; Cragg Gordon; McPhail Andrew T; Nozaki Hiroshi; Lee Kuo-Hsiung
Antitumor agents. 233. Lantalucratins A-F, new cytotoxic naphthoquinones from Lantana involucrata.
Journal of natural products 2004;67(6):990-3.
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2004: Li Chia-Ying; Lin Chun-Hua; Wu Chia-Che; Lee Kuo-Hsiung; Wu Tian-Shung
Efficient 1H nuclear magnetic resonance method for improved quality control analyses of Ginkgo constituents.
Journal of agricultural and food chemistry 2004;52(12):3721-5.
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2004: Xiao Zhiyan; Vance John R; Bastow Kenneth F; Brossi Arnold; Wang Hui-Kang; Lee Kuo-Hsiung
Antitumor agents. Part 235: Novel 4'-ester etoposide analogues as potent DNA topoisomerase II inhibitors with improved therapeutic potential.
Bioorganic & medicinal chemistry 2004;12(12):3363-9.
-
2004: Xiao Zhiyan; Bastow Kenneth F; Vance John R; Lee Kuo-Hsiung
Antitumor agents. Part 227: Studies on novel 4'-O-demethyl-epipodophyllotoxins as antitumor agents targeting topoisomerase II.
Bioorganic & medicinal chemistry 2004;12(12):3339-44.
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2004: Xia Peng; Yin Zhi-Jian; Chen Ying; Zhang Qian; Zhang Beina; Xia Yi; Yang Zheng-Yu; Kilgore Nicole; Wild Carl; Morris-Natschke Susan L; Lee Kuo-Hsiung
Anti-AIDS agents. Part 58: synthesis and anti-HIV activity of 1-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (1-thia-DCK) analogues.
Bioorganic & medicinal chemistry letters 2004;14(12):3341-3.
-
2004: Han Shiqing; Xiao Zhiyan; Bastow Kenneth F; Lee Kuo-Hsiung
Antitumor agents. Part 230: C4'-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(11):2979-82.
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2004: Wang Yong-Hong; Hou Ai-Jun; Chen Lei; Chen Dao-Feng; Sun Han-Dong; Zhao Qin-Shi; Bastow Kenneth F; Nakanish Yuka; Wang Xi-Hong; Lee Kuo-Hsiung
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
Journal of natural products 2004;67(5):757-61.
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2004: Lin Ru-Wei; Tsai Ian-Lih; Duh Chang-Yih; Lee Kuo-Hsiung; Chen Ih-Sheng
New lignans and cytotoxic constituents from Wikstroemia lanceolata.
Planta medica 2004;70(3):234-8.
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2004: Xiao Zhiyan; Han Shiqing; Bastow Kenneth F; Lee Kuo-Hsiung
Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents.
Bioorganic & medicinal chemistry letters 2004;14(6):1581-4.
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2004: Wu Pei-Lin; Lin Fu-Wen; Wu Tian-Shung; Kuoh Chang-Sheng; Lee Kuo-Hsiung; Lee Shiow-Ju
Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis.
Chemical & pharmaceutical bulletin 2004;52(3):345-9.
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2004: Sakurai Nobuko; Wu Jiu-Hong; Sashida Yutaka; Mimaki Yoshihiro; Nikaido Tamotsu; Koike Kazuo; Itokawa Hideji; Lee Kuo-Hsiung
Anti-AIDS agents. Part 57: Actein, an anti-HIV principle from the rhizome of Cimicifuga racemosa (black cohosh), and the anti-HIV activity of related saponins.
Bioorganic & medicinal chemistry letters 2004;14(5):1329-32.
-
2004: Lee Kuo-Hsiung
Current developments in the discovery and design of new drug candidates from plant natural product leads.
Journal of natural products 2004;67(2):273-83.
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2004: Kuo Ping-Chung; Damu Amooru G; Lee Kuo-Hsiung; Wu Tian-Shung
Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia.
Bioorganic & medicinal chemistry 2004;12(3):537-44.
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2004: Xie Lan; Yu Donglei; Wild Carl; Allaway Graham; Turpin Jim; Smith Philip C; Lee Kuo-Hsiung
Anti-AIDS agents. 52. Synthesis and anti-HIV activity of hydroxymethyl (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone derivatives.
Journal of medicinal chemistry 2004;47(3):756-60.
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2004: Zhou Jing; Yuan Xiong; Dismuke David; Forshey Brett M; Lundquist Christopher; Lee Kuo-Hsiung; Aiken Christopher; Chen Chin Ho
Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation.
Journal of virology 2004;78(2):922-9.
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2003: Hsieh Pei-Wen; Chang Fang-Rong; McPhail Andrew T; Lee Kuo-Hsiung; Wu Yang-Chang
New cembranolide analogues from the formosan soft coral Sinularia flexibilis and their cytotoxicity.
Natural product research 2003;17(6):409-18.
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2003: Chang Fang-Rong; Hayashi Ken-Ichiro; Chen I-Hsiao; Liaw Chih-Chuang; Bastow Kenneth F; Nakanishi Yuka; Nozaki Hiroshi; Cragg Gordon M; Wu Yang-Chang; Lee Kuo-Hsiung
Antitumor agents. 228. five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii.
Journal of natural products 2003;66(11):1416-20.
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2003: Ohtsu Hironori; Itokawa Hideji; Xiao Zhiyan; Su Ching-Yuan; Shih Charles C-Y; Chiang Tzuying; Chang Eugene; Lee YiFen; Chiu Shang Yi; Chang Chawnshang; Lee Kuo-Hsiung
Antitumor agents 222. Synthesis and anti-androgen activity of new diarylheptanoids.
Bioorganic & medicinal chemistry 2003;11(23):5083-90.
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2003: Kuo Ping-Chung; Shi Li-Shian; Damu Amooru G; Su Chung-Ren; Huang Chieh-Hung; Ke Chih-Huang; Wu Jin-Bin; Lin Ai-Jeng; Bastow Kenneth F; Lee Kuo-Hsiung; Wu Tian-Shung
Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia.
Journal of natural products 2003;66(10):1324-7.
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2003: Xia Yi; Yang Zheng-Yu; Xia Peng; Bastow Kenneth F; Nakanishi Yuka; Nampoothiri Priya; Hamel Ernest; Brossi Arnold; Lee Kuo-Hsiung
Antitumor agents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters.
Bioorganic & medicinal chemistry letters 2003;13(17):2891-3.
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2003: Zou Zheng-Rong; Yi Yang-Hua; Wu Hou-Ming; Wu Jiu-Hong; Liaw Chih-Chaung; Lee Kuo-Hsiung
Intercedensides A-C, three new cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert.
Journal of natural products 2003;66(8):1055-60.
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2003: Nakanishi Yuka; Chang Fang-Rong; Liaw Chih-Chuang; Wu Yang-Chang; Bastow Kenneth F; Lee Kuo-Hsiung
Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.
Journal of medicinal chemistry 2003;46(15):3185-8.
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2003: Wu Jiu Hong; Chang Fang Rong; Hayashi Ken ichiro; Shiraki Hiroaki; Liaw Chih Chuang; Nakanishi Yuka; Bastow Kenneth F; Yu Donglei; Chen Ih Sheng; Lee Kuo Hsiung
Antitumor agents. Part 218: Cappamensin A, a new In vitro anticancer principle, from Capparis sikkimensis.
Bioorganic & medicinal chemistry letters 2003;13(13):2223-5.
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2003: Wu Jiu-Hong; Wang Xi-Hong; Yi Yang-Hua; Lee Kuo-Hsiung
Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from genus Desmos.
Bioorganic & medicinal chemistry letters 2003;13(10):1813-5.
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2003: Yu Donglei; Brossi Arnold; Kilgore Nicole; Wild Carl; Allaway Graham; Lee Kuo-Hsiung
Anti-HIV agents. Part 55: 3'R,4'R-Di-(O)-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP), a novel anti-HIV agent.
Bioorganic & medicinal chemistry letters 2003;13(9):1575-6.
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2003: Yu Donglei; Suzuki Madoka; Xie Lan; Morris-Natschke Susan L; Lee Kuo-Hsiung
Recent progress in the development of coumarin derivatives as potent anti-HIV agents.
Medicinal research reviews 2003;23(3):322-45.
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2003: Lo Wen-Li; Wu Chin-Chung; Chang Fang-Rong; Wang Wei-Ya; Khalil Ashraf Taha; Lee Kuo-Hsiung; Wu Yang-Chang
Antiplatelet and anti-HIV constituents from Euchresta formosana.
Natural product research 2003;17(2):91-7.
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2003: Ohtsu Hironori; Nakanishi Yuka; Bastow Kenneth F; Lee Fang-Yu; Lee Kuo Hsiung
Antitumor agents 216. Synthesis and evaluation of paclitaxel-camptothecin conjugates as novel cytotoxic agents.
Bioorganic & medicinal chemistry 2003;11(8):1851-7.
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2003: Sakurai Nobuko; Kozuka Mutsuo; Tokuda Harukuni; Nobukuni Yoshitaka; Takayasu Junko; Nishino Hoyoku; Kusano Akiko; Kusano Genjiro; Nagai Masahiro; Sakurai Yojiro; Lee Kuo Hsiung
Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Bioorganic & medicinal chemistry 2003;11(6):1137-40.
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2003: Zhang Qian; Chen Ying; Zheng Yun Qing; Xia Peng; Xia Yi; Yang Zheng Yu; Bastow Kenneth F; Morris-Natschke Susan L; Lee Kuo Hsiung
Synthesis and bioactivity of 4,10-dimethyl-pyridino[2,3-h]quinolin-2(1H)-one-9-carboxylic acid and its esters.
Bioorganic & medicinal chemistry 2003;11(6):1031-4.
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2003: Golbraikh Alexander; Shen Min; Xiao Zhiyan; Xiao Yun-De; Lee Kuo-Hsiung; Tropsha Alexander
Rational selection of training and test sets for the development of validated QSAR models.
Journal of computer-aided molecular design 2003;17(2-4):241-53.
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2003: Chang Yuh-Chwen; Hsieh Pei-Wen; Chang Fang-Rong; Wu Ru-Rong; Liaw Chih-Chuang; Lee Kuo-Hsiung; Wu Yang-Chang
Two new protopines argemexicaines A and B and the anti-HIV alkaloid 6-acetonyldihydrochelerythrine from formosan Argemone mexicana.
Planta medica 2003;69(2):148-52.
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2003: Hayashi Ken-Ichiro; Nakanishi Yuka; Bastow Kenneth F; Cragg Gordon; Nozaki Hiroshi; Lee Kuo-Hsiung
Antitumor agents. 221.1 buceracidins A and B, two new flavanones from Bucida buceras.
Journal of natural products 2003;66(1):125-7.
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2003: Sun I-Chen; Kashiwada Yoshiki; Morris-Natschke Susan L; Lee Kuo-Hsiung
Plant-derived terpenoids and analogues as anti-HIV agents.
Current topics in medicinal chemistry 2003;3(2):155-69.
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2002: Bruno Maurizio; Rosselli Sergio; Pibiri Ivana; Kilgore Nicole; Lee Kuo-Hsiung
Anti-HIV agents derived from the ent-kaurane diterpenoid linearol.
Journal of natural products 2002;65(11):1594-7.
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2002: Ohtsu Hironori; Xiao Zhiyan; Ishida Junko; Nagai Masahiro; Wang Hui-Kang; Itokawa Hideji; Su Ching-Yuan; Shih Charles; Chiang Tzuying; Chang Eugene; Lee YiFen; Tsai Meng-Yin; Chang Chawnshang; Lee Kuo-Hsiung
Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents.
Journal of medicinal chemistry 2002;45(23):5037-42.
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2002: Ishida Junko; Ohtsu Hironori; Tachibana Yoko; Nakanishi Yuka; Bastow Kenneth F; Nagai Masahiro; Wang Hui-Kang; Itokawa Hideji; Lee Kuo-Hsiung
Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents.
Bioorganic & medicinal chemistry 2002;10(11):3481-7.
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2002: Han Shiqing; Hamel Ernest; Bastow Kenneth F; McPhail Andrew T; Brossi Arnold; Lee Kuo-Hsiung
Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.
Bioorganic & medicinal chemistry letters 2002;12(20):2851-3.
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2002: Shinozaki Youichi; Fukamiya Narihiko; Uchiyama Chieko; Okano Masayoshi; Tagahara Kiyoshi; Bastow Kenneth F; Lee Kuo-Hsiung
Multidrug resistant cancer cells susceptibility to cytotoxic taxane diterpenes from Taxus yunnanensis and Taxus chinensis.
Bioorganic & medicinal chemistry letters 2002;12(19):2785-8.
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2002: Ishida Junko; Kozuka Mutsuo; Tokuda Harukuni; Nishino Hoyoku; Nagumo Seiji; Lee Kuo Hsiung; Nagai Masahiro
Chemopreventive potential of cyclic diarylheptanoids.
Bioorganic & medicinal chemistry 2002;10(10):3361-5.
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2002: Chen Dao-Feng; Zhang Shun-Xiang; Kozuka Mutsuo; Sun Quan-Zhong; Feng Ju; Wang Qiang; Mukainaka Teruo; Nobukuni Yoshitaka; Tokuda Harukuni; Nishino Hoyoku; Wang Hui-Kang; Morris-Natschke Susan L; Lee Kuo-Hsiung
Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.
Journal of natural products 2002;65(9):1242-5.
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2002: Sun I-Chen; Chen Chin-Ho; Kashiwada Yoshiki; Wu Jiu-Hong; Wang Hui-Kang; Lee Kuo-Hsiung
Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid.
Journal of medicinal chemistry 2002;45(19):4271-5.
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2002: Xiao Zhiyan; Xiao Yun-De; Feng Jun; Golbraikh Alexander; Tropsha Alexander; Lee Kuo-Hsiung
Antitumor agents. 213. Modeling of epipodophyllotoxin derivatives using variable selection k nearest neighbor QSAR method.
Journal of medicinal chemistry 2002;45(11):2294-309.
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2002: Shinozaki Youichi; Fukamiya Narihiko; Fukushima Masao; Okano Masayoshi; Nehira Tatsuo; Tagahara Kiyoshi; Zhang Shun-Xiang; Zhang De-Cheng; Lee Kuo-Hsiung
Dantaxusins C and D, two novel taxoids from Taxus yunnanensis.
Journal of natural products 2002;65(3):371-4.
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2002: Wongsinkongman Prapai; Brossi Arnold; Wang Hui-Kang; Bastow Kenneth F; Lee Kuo-Hsiung
Antitumor agents. Part 209: Pheophorbide-a derivatives as photo-Independent cytotoxic agents.
Bioorganic & medicinal chemistry 2002;10(3):583-91.
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2002: Hayashi Ken-ichiro; Nakanishi Yuka; Bastow Kenneth F; Cragg Gordon; Nozaki Hiroshi; Lee Kuo-Hsiung
Antitumor agents. Part 212. Bucidarasins A-C, three new cytotoxic clerodane diterpenes from Bucida buceras.
Bioorganic & medicinal chemistry letters 2002;12(3):345-8.
-
2001: Cheng H I; Lin W Y; Duh C Y; Lee K H; Tsai I L; Chen I S
New cytotoxic butanolides from Litsea acutivena.
Journal of natural products 2001;64(12):1502-5.
-
2001: Zhu Y M; Shen J K; Wang H K; Cosentino L M; Lee K H
Synthesis and anti-HIV activity of oleanolic acid derivatives.
Bioorganic & medicinal chemistry letters 2001;11(24):3115-8.
-
2001: Xia Y; Yang Z Y; Xia P; Hackl T; Hamel E; Mauger A; Wu J H; Lee K H
Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents.
Journal of medicinal chemistry 2001;44(23):3932-6.
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2001: Shi Q; Wang H K; Bastow K F; Tachibana Y; Chen K; Lee F Y; Lee K H
Antitumor agents 210. Synthesis and evaluation of taxoid-epipodophyllotoxin conjugates as novel cytotoxic agents.
Bioorganic & medicinal chemistry 2001;9(11):2999-3004.
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2001: Ito J; Chang F R; Wang H K; Park Y K; Ikegaki M; Kilgore N; Lee K H
Anti-AIDS agents. 48.(1) Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis.
Journal of natural products 2001;64(10):1278-81.
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2001: Xie L; Allaway G; Wild C; Kilgore N; Lee K H
Anti-AIDS agents. Part 47: Synthesis and anti-HIV activity of 3-substituted 3',4'-Di-O-(S)-camphanoyl-(3'R,4'R)-(+)-cis-khellactone derivatives.
Bioorganic & medicinal chemistry letters 2001;11(17):2291-3.
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2001: Shinozaki Y; Fukamiya N; Fukushima M; Okano M; Nehira T; Tagahara K; Zhang S X; Zhang D C; Lee K H
Dantaxusins A and B, two new taxoids from Taxus yunnanensis.
Journal of natural products 2001;64(8):1073-6.
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2001: Ishida J; Wang H K; Oyama M; Cosentino M L; Hu C Q; Lee K H
Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives.
Journal of natural products 2001;64(7):958-60.
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2001: Cheng H H; Wang H K; Ito J; Bastow K F; Tachibana Y; Nakanishi Y; Xu Z; Luo T Y; Lee K H
Cytotoxic pheophorbide-related compounds from Clerodendrum calamitosum and C. cyrtophyllum.
Journal of natural products 2001;64(7):915-9.
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2001: Shikishima Y; Takaishi Y; Honda G; Ito M; Takfda Y; Kodzhimatov O K; Ashurmetov O; Lee K H
Chemical constituents of Prangos tschiniganica; structure elucidation and absolute configuration of coumarin and furanocoumarin derivatives with anti-HIV activity.
Chemical & pharmaceutical bulletin 2001;49(7):877-80.
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2001: Kuo Y H; Li S Y; Huang R L; Wu M D; Huang H C; Lee K H
Schizanrins [corrected] B, C, D, and E, four new lignans from Kadsura matsudai and their antihepatitis activities.
Journal of natural products 2001;64(4):487-90.
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2001: VanVliet D S; Tachibana Y; Bastow K F; Huang E S; Lee K H
Antitumor agents. 207. Design, synthesis, and biological testing of 4beta-anilino-2-fluoro-4'-demethylpodophyllotoxin analogues as cytotoxic and antiviral agents.
Journal of medicinal chemistry 2001;44(9):1422-8.
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2001: Xie L; Takeuchi Y; Cosentino L M; McPhail A T; Lee K H
Anti-AIDS agents. 42. Synthesis and anti-HIV activity of disubstituted (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone analogues.
Journal of medicinal chemistry 2001;44(5):664-71.
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2001: Ko T C; Hour M J; Lien J C; Teng C M; Lee K H; Kuo S C; Huang L J
Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents.
Bioorganic & medicinal chemistry letters 2001;11(3):279-82.
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2001: Wu T S; Tsang Z J; Wu P L; Lin F W; Li C Y; Teng C M; Lee K H
New constituents and antiplatelet aggregation and anti-HIV principles of Artemisia capillaris.
Bioorganic & medicinal chemistry 2001;9(1):77-83.
-
2000: Lee K H
Research and future trends in the pharmaceutical development of medicinal herbs from Chinese medicine.
Public health nutrition 2000;3(4A):515-22.
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2000: Li S Y; Wu M D; Wang C W; Kuo Y H; Huang R L; Lee K H
A novel anti-HBeAg homolignan, taiwanschirin D from Kadsura matsudai.
Chemical & pharmaceutical bulletin 2000;48(12):1992-3.
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2000: Xu Z; Chang F R; Wang H K; Kashiwada Y; McPhail A T; Bastow K F; Tachibana Y; Cosentino M; Lee K H
Anti-HIV agents 45(1) and antitumor agents 205.(2) two new sesquiterpenes, leitneridanins A and B, and the cytotoxic and anti-HIV principles from Leitneria floridana.
Journal of natural products 2000;63(12):1712-5.
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2000: Kashiwada Y; Nagao T; Hashimoto A; Ikeshiro Y; Okabe H; Cosentino L M; Lee K H
Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives.
Journal of natural products 2000;63(12):1619-22.
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2000: Hour M J; Huang L J; Kuo S C; Xia Y; Bastow K; Nakanishi Y; Hamel E; Lee K H
6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry 2000;43(23):4479-87.
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2000: Ishida J; Kozuka M; Wang H; Konoshima T; Tokuda H; Okuda M; Yang Mou X; Nishino H; Sakurai N; Lee K H; Nagai M
Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Cancer letters 2000;159(2):135-40.
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2000: Fukushima M; Fukamiya N; Okano M; Nehira T; Tagahara K; Zhang S X; Zhang D C; Tachibana Y; Bastow K F; Lee K H
Cytotoxity of non-alkaloidal taxane diterpenes from Taxus chinensis against a paclitaxel-resistant cell line.
Cancer letters 2000;158(2):151-4.
-
2000: Itoigawa M; Kashiwada Y; Ito C; Furukawa H; Tachibana Y; Bastow K F; Lee K H
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
Journal of natural products 2000;63(7):893-7.
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2000: Tzeng C C; Lee K H; Wang T C; Han C H; Chen Y L
Synthesis and cytotoxic evaluation of a series of gamma-substituted gamma-aryloxymethyl-alpha-methylene-gamma-butyrolactones against cancer cells.
Pharmaceutical research 2000;17(6):715-9.
-
2000: Tamura S; Fukamiya N; Mou X Y; Mukainaka T; Tokuda H; Nishino H; Tagahara K; Koike K; Lee K H; Okano M
Conversion of quassinoids for enhancement of inhibitory effect against Epstein-Barr virus early antigen activation. Introduction of lipophilic side chain and esterification of diosphenol.
Chemical & pharmaceutical bulletin 2000;48(6):876-8.
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2000: Yang Z Y; Xia Y; Xia P; Brossi A; Cosentino L M; Lee K H
Anti-AIDS agents part 41: synthesis and anti-HIV activity of 3',4'-di-o-(-)-camphanoyl-(+)-cis-khellactone (DCK) lactam analogues.
Bioorganic & medicinal chemistry letters 2000;10(10):1003-5.
-
2000: Xia Y; Yang Z Y; Xia P; Bastow K F; Nakanishi Y; Lee K H
Antitumor agents. Part 202: novel 2'-amino chalcones: design, synthesis and biological evaluation.
Bioorganic & medicinal chemistry letters 2000;10(8):699-701.
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2000: Duan H; Takaishi Y; Imakura Y; Jia Y; Li D; Cosentino L M; Lee K H
Sesquiterpene alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii: a new class of potent anti-HIV agents.
Journal of natural products 2000;63(3):357-61.
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2000: Zhou P; Takaishi Y; Duan H; Chen B; Honda G; Itoh M; Takeda Y; Kodzhimatov O K; Lee K H
Coumarins and bicoumarin from Ferula sumbul: anti-HIV activity and inhibition of cytokine release.
Phytochemistry 2000;53(6):689-97.
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2000: Chang J Y; Guo X; Chen H X; Jiang Z; Fu Q; Wang H K; Bastow K F; Zhu X K; Guan J; Lee K H; Cheng Y C
Unique biochemical, cytotoxic, and antitumor activity of camptothecin and 4beta-amino-4'-O-demethylepipodophyllotoxin conjugates.
Biochemical pharmacology 2000;59(5):497-508.
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2000: Tachibana Y; Zhu X K; Krishnan P; Lee K H; Bastow K F
Characterization of human lung cancer cells resistant to 4'-O-demethyl-4beta-(2"-nitro-4"-fluoroanilino)-4-desoxypodophyllotoxin , a unique compound in the epipodophyllotoxin antitumor class.
Anti-cancer drugs 2000;11(1):19-28.
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2000: Zhang S X; Feng J; Kuo S C; Brossi A; Hamel E; Tropsha A; Lee K H
Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis.
Journal of medicinal chemistry 2000;43(2):167-76.
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1999: Xia Y; Yang Z Y; Brossi A; Lee K H
Asymmetric solid-phase synthesis of (3'R,4'R)-di-O-cis-acyl 3-carboxyl khellactones.
Organic letters 1999;1(13):2113-5.
-
1999: Ishida J; Wang H K; Bastow K F; Hu C Q; Lee K H
Antitumor agents 201. Cytotoxicity of harmine and beta-carboline analogs.
Bioorganic & medicinal chemistry letters 1999;9(23):3319-24.
-
1999: Lee K H
Novel antitumor agents from higher plants.
Medicinal research reviews 1999;19(6):569-96.
-
1999: Ohyama M; Tanaka T; Ito T; Iinuma M; Bastow K F; Lee K H
Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives.
Bioorganic & medicinal chemistry letters 1999;9(20):3057-60.
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1999: Zhang S X; Bastow K F; Tachibana Y; Kuo S C; Hamel E; Mauger A; Narayanan V L; Lee K H
Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry 1999;42(20):4081-7.
-
1999: Xia P; Yang Z Y; Xia Y; Zheng Y Q; Cosentino L M; Lee K H
Anti-AIDS agents. Part 36: 17-carboxylated steroids as potential anti-HIV agents.
Bioorganic & medicinal chemistry 1999;7(9):1907-11.
-
1999: Lee K H
Anticancer drug design based on plant-derived natural products.
Journal of biomedical science 1999;6(4):236-50.
-
1999: Xie L; Takeuchi Y; Cosentino L M; Lee K H
Anti-AIDS agents. 37. Synthesis and structure-activity relationships of (3'R,4'R)-(+)-cis-khellactone derivatives as novel potent anti-HIV agents.
Journal of medicinal chemistry 1999;42(14):2662-72.
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1999: Zhu X K; Guan J; Tachibana Y; Bastow K F; Cho S J; Cheng H H; Cheng Y C; Gurwith M; Lee K H
Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles.
Journal of medicinal chemistry 1999;42(13):2441-6.
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1999: Chao Y H; Kuo S C; Ku K; Chiu I P; Wu C H; Mauger A; Wang H K; Lee K H
Synthesis and cytotoxicity of methyl-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione derivatives.
Bioorganic & medicinal chemistry 1999;7(6):1025-31.
-
1999: Xia Y; Yang Z Y; Morris-Natschke S L; Lee K H
Recent advances in the discovery and development of quinolones and analogs as antitumor agents.
Current medicinal chemistry 1999;6(3):179-94.
-
1999: Yang Z Y; Xia Y; Xia P; Tachibana Y; Bastow K F; Lee K H
Antitumor agents 187: synthesis and cytotoxicity of substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-one and related compounds.
Bioorganic & medicinal chemistry letters 1999;9(5):713-6.
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1999: Hayashi T; Nakano T; Kozuka M; McPhail D R; McPhail A T; Lee K H
Antitumor agents. 190. Absolute stereochemistry of the cytotoxic germacranolides, tomenphantins A and B, from Elephantopus tomentosus.
Journal of natural products 1999;62(2):302-4.
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1999: Lee K H; Huang B R; Tzeng C C
Synthesis and anticancer evaluation of certain alpha-methylene-gamma-(4-substituted phenyl)-gamma-butyrolactone bearing thymine, uracil, and 5-bromouracil.
Bioorganic & medicinal chemistry letters 1999;9(2):241-4.
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1999: Fukushima M; Takeda J; Fukamiya N; Okano M; Tagahara K; Zhang S X; Zhang D C; Lee K H
A new taxoid, 19-acetoxytaxagifine, from Taxus chinensis.
Journal of natural products 1999;62(1):140-2.
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1999: Chen D F; Zhang S X; Wang H K; Zhang S Y; Sun Q Z; Cosentino L M; Lee K H
Novel anti-HIV lancilactone C and related triterpenes from Kadsura lancilimba.
Journal of natural products 1999;62(1):94-7.
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1999: Chen K; Shi Q; Li Z L; Poon C D; Tang R J; Lee K H
Structures and stereochemistry of pseudolarolides K and L, novel triterpene dilactones from pseudolarix kaempferi.
Journal of Asian natural products research 1999;1(3):207-14.
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1998: Fujioka T; Yamamoto M; Kashiwada Y; Fujii H; Mihashi K; Ikeshiro Y; Chen I S; Lee K H
Novel cytotoxic diterpenes from the stem of Dysoxylum kuskusense.
Bioorganic & medicinal chemistry letters 1998;8(24):3479-82.
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1998: Huang L J; Chang F C; Lee K H; Wang J P; Teng C M; Kuo S C
Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of substituted 3-chloro-5,8-dimethoxy-1,4-naphthoquinone and related compounds.
Bioorganic & medicinal chemistry 1998;6(12):2261-9.
-
1998: Guan J; Zhu X K; Tachibana Y; Bastow K F; Brossi A; Hamel E; Lee K H
Antitumor agents. Part 186: Synthesis and biological evaluation of demethylcolchiceinamide analogues as cytotoxic DNA topoisomerase II inhibitors.
Bioorganic & medicinal chemistry 1998;6(11):2127-31.
-
1998: Chao Y H; Kuo S C; Wu C H; Lee C Y; Mauger A; Sun I C; Morris-Natschke S L; Lee K H
Synthesis and cytotoxicity of 2-acetyl-4,8-dihydrobenzodithiophene-4, 8-dione derivatives.
Journal of medicinal chemistry 1998;41(23):4658-61.
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1998: Sun I C; Wang H K; Kashiwada Y; Shen J K; Cosentino L M; Chen C H; Yang L M; Lee K H
Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents.
Journal of medicinal chemistry 1998;41(23):4648-57.
-
1998: Wang T C; Lee K H; Chen Y L; Liou S S; Tzeng C C
Synthesis and anticancer evaluation of certain gamma-aryloxymethyl-alpha-methylene-gamma-phenyl-gamma-butyrolactones.
Bioorganic & medicinal chemistry letters 1998;8(19):2773-6.
-
1998: Huang L J; Kuo S C; Perng C Y; Chao Y H; Wu T S; McPhail A T; Mauger A; Cheng H H; Lee K H
Synthesis and cytotoxicity of acetyl-4H,9H-naphtho[2,3-b]thiophene-4,9-diones.
Bioorganic & medicinal chemistry letters 1998;8(19):2763-8.
-
1998: Huang L J; Hsieh M C; Teng C M; Lee K H; Kuo S C
Synthesis and antiplatelet activity of phenyl quinolones.
Bioorganic & medicinal chemistry 1998;6(10):1657-62.
-
1998: Kashiwada Y; Wang H K; Nagao T; Kitanaka S; Yasuda I; Fujioka T; Yamagishi T; Cosentino L M; Kozuka M; Okabe H; Ikeshiro Y; Hu C Q; Yeh E; Lee K H
Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids.
Journal of natural products 1998;61(9):1090-5.
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1998: Xie L; Takeuchi Y; Cosentino L M; Lee K H
Anti-AIDS agents. 33. Synthesis and anti-HIV activity of mono-methyl substituted 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) analogues.
Bioorganic & medicinal chemistry letters 1998;8(16):2151-6.
-
1998: Shi Q; Chen K; Morris-Natschke S L; Lee K H
Recent progress in the development of tubulin inhibitors as antimitotic antitumor agents.
Current pharmaceutical design 1998;4(3):219-48.
-
1998: Yang Z Y; Xia Y; Xia P; Cosentino L M; Lee K H
Anti-AIDS agents. 31. Synthesis and anti-HIV activity of 4-substituted 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) thiolactone analogs.
Bioorganic & medicinal chemistry letters 1998;8(12):1483-6.
-
1998: Sun I C; Shen J K; Wang H K; Cosentino L M; Lee K H
Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives.
Bioorganic & medicinal chemistry letters 1998;8(10):1267-72.
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1998: Guan J; Zhu X K; Tachibana Y; Bastow K F; Brossi A; Hamel E; Lee K H
Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.
Journal of medicinal chemistry 1998;41(11):1956-61.
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1998: Xia Y; Yang Z Y; Xia P; Bastow K F; Tachibana Y; Kuo S C; Hamel E; Hackl T; Lee K H
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
Journal of medicinal chemistry 1998;41(7):1155-62.
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1997: Shi Q; Verdier-Pinard P; Brossi A; Hamel E; Lee K H
Antitumor agents--CLXXV. Anti-tubulin action of (+)-thiocolchicine prepared by partial synthesis.
Bioorganic & medicinal chemistry 1997;5(12):2277-82.
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1997: Lien J C; Huang L J; Wang J P; Teng C M; Lee K H; Kuo S C
Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of 2-substituted 3-chloro-1,4-naphthoquinone derivatives.
Bioorganic & medicinal chemistry 1997;5(12):2111-20.
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1997: Kashiwada Y; Fujioka T; Mihashi K; Chen I S; Katayama H; Ikeshiro Y; Lee K H
Antitumor agents. 180. Chemical Studies and cytotoxic evaluation of cumingianosides and cumindysoside A, antileukemic triterpene glucosides with a 14,18-cycloapotirucallane skeleton.
Journal of natural products 1997;60(11):1105-14.
-
1997: Rahman S; Fukamiya N; Okano M; Tagahara K; Lee K H
Anti-tuberculosis activity of quassinoids.
Chemical & pharmaceutical bulletin 1997;45(9):1527-9.
-
1997: Chen K; Kuo S C; Hsieh M C; Mauger A; Lin C M; Hamel E; Lee K H
Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization.
Journal of medicinal chemistry 1997;40(19):3049-56.
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1997: Ohno N; Fukamiya N; Okano M; Tagahara K; Lee K H
Synthesis of cytotoxic fluorinated quassinoids.
Bioorganic & medicinal chemistry 1997;5(8):1489-95.
-
1997: Bastow K F; Wang H K; Cheng Y C; Lee K H
Antitumor agents--CLXXIII. Synthesis and evaluation of camptothecin-4 beta-amino-4'-O-demethyl epipodophyllotoxin conjugates as inhibitors of mammalian DNA topoisomerases and as cytotoxic agents.
Bioorganic & medicinal chemistry 1997;5(8):1481-8.
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1997: Johnson M G; Kiyokawa H; Tani S; Koyama J; Morris-Natschke S L; Mauger A; Bowers-Daines M M; Lange B C; Lee K H
Antitumor agents--CLXVII. Synthesis and structure-activity correlations of the cytotoxic anthraquinone 1,4-bis-(2,3-epoxypropylamino)-9,10-anthracenedione, and of related compounds.
Bioorganic & medicinal chemistry 1997;5(8):1469-79.
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1997: Chen K; Kuo S C; Hsieh M C; Mauger A; Lin C M; Hamel E; Lee K H
Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry 1997;40(14):2266-75.
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1997: Wang H K; Morris-Natschke S L; Lee K H
Recent advances in the discovery and development of topoisomerase inhibitors as antitumor agents.
Medicinal research reviews 1997;17(4):367-425.
-
1997: Rahman S; Fukamiya N; Ohno N; Tokuda H; Nishino H; Tagahara K; Lee K H; Okano M
Inhibitory effects of quassinoid derivatives on Epstein-Barr virus early antigen activation.
Chemical & pharmaceutical bulletin 1997;45(4):675-7.
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1997: Shi Q; Verdier-Pinard P; Brossi A; Hamel E; McPhail A T; Lee K H
Antitumor agents. 172. Synthesis and biological evaluation of novel deacetamidothiocolchicin-7-ols and ester analogs as antitubulin agents.
Journal of medicinal chemistry 1997;40(6):961-6.
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1997: Kubota K; Fukamiya N; Tokuda H; Nishino H; Tagahara K; Lee K H; Okano M
Quassinoids as inhibitors of Epstein-Barr virus early antigen activation.
Cancer letters 1997;113(1-2):165-8.
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1997: Fujioka T; Sakurai A; Mihashi K; Kashiwada Y; Chen I S; Lee K H
Antitumor agents. 169 Dysoxylum cumingianum. V. Cumingianosides P and Q, new cytotoxic triterpene glucosides with an apotirucallane-type skeleton from Dysoxylum cumingianum.
Chemical & pharmaceutical bulletin 1997;45(1):202-6.
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1997: Fujioka T; Sakurai A; Mihashi K; Kashiwada Y; Chen I S; Lee K H
Antitumor agents. 168. Dysoxylum cumingianum. IV. The structures of cumingianosides G-O, new triterpene glucosides with a 14,18-cycloapotirucallane-type skeleton from Dysoxylum cumingianum, and their cytotoxicity against human cancer cell lines.
Chemical & pharmaceutical bulletin 1997;45(1):68-74.
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1996: Chen K; Zhang Y L; Li Z L; Shi Q; Poon C D; Tang R J; McPhail A T; Lee K H
Structure and stereochemistry of pseudolarolide J, a novel nortriterpene lactone from Pseudolarix kaempferi.
Journal of natural products 1996;59(12):1200-2.
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1996: Kubota K; Fukamiya N; Hamada T; Okano M; Tagahara K; Lee K H
Two new quassinoids, ailantinols A and B, and related compounds from Ailanthus altissima.
Journal of natural products 1996;59(7):683-6.
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1996: Lien J C; Huang L J; Wang J P; Teng C M; Lee K H; Kuo S C
Synthesis and antiplatelet, antiinflammatory and antiallergic activities of 2,3-disubstituted 1,4-naphthoquinones.
Chemical & pharmaceutical bulletin 1996;44(6):1181-7.
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1996: Wang H K; Bastow K F; Cosentino L M; Lee K H
Antitumor agents. 166. Synthesis and biological evaluation of 5,6,7,8-substituted-2-phenylthiochromen-4-ones.
Journal of medicinal chemistry 1996;39(10):1975-80.
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1996: Kuo S C; Ibuka T; Huang L J; Lien J C; Yean S R; Huang S C; Lednicer D; Morris-Natschke S; Lee K H
Synthesis and cytotoxicity of 1,2-disubstituted naphth[2,3-d]imidazole-4,9-diones and related compounds.
Journal of medicinal chemistry 1996;39(7):1447-51.
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1996: Cho S J; Kashiwada Y; Bastow K F; Cheng Y C; Lee K H
Antitumor agents. 164. Podophenazine, 2'',3''-dichloropodophenazine, benzopodophenazine, and their 4 beta-p-nitroaniline derivatives as novel DNA topoisomerase II inhibitors.
Journal of medicinal chemistry 1996;39(7):1396-402.
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1996: Cho S J; Tropsha A; Suffness M; Cheng Y C; Lee K H
Antitumor agents. 163. Three-dimensional quantitative structure-activity relationship study of 4'-O-demethylepipodophyllotoxin analogs using the modified CoMFA/q2-GRS approach.
Journal of medicinal chemistry 1996;39(7):1383-95.
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1996: Kashiwada Y; Hashimoto F; Cosentino L M; Chen C H; Garrett P E; Lee K H
Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents.
Journal of medicinal chemistry 1996;39(5):1016-7.
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1995: Imamura K; Fukamiya N; Nakamura M; Okano M; Tagahara K; Lee K H
Bruceanols G and H cytotoxic quassinoids from Brucea antidysenterica.
Journal of natural products 1995;58(12):1915-9.
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1995: Kuo Y H; Chen C F; Kuo L M; King M L; Chen C F; Lee K H
Celahinine A, a new sesquiterpene pyridine alkaloid from Celastrus hindsii.
Journal of natural products 1995;58(11):1735-8.
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1995: Chen K; Shi Q; Fujioka T; Nakano T; Hu C Q; Jin J Q; Kilkuskie R E; Lee K H
Anti-AIDS agents--XIX. Neotripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation.
Bioorganic & medicinal chemistry 1995;3(10):1345-8.
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1995: Konoshima T; Yasuda I; Kashiwada Y; Cosentino L M; Lee K H
Anti-AIDS agents, 21. Triterpenoid saponins as anti-HIV principles from fruits of Gleditsia japonica and Gymnocladus chinensis, and a structure-activity correlation.
Journal of natural products 1995;58(9):1372-7.
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1995: Okano M; Fukamiya N; Tagahara K; Tokuda H; Iwashima A; Nishino H; Lee K H
Inhibitory effects of quassinoids on Epstein-Barr virus activation.
Cancer letters 1995;94(2):139-46.
-
1995: Xie L; Xie J X; Kashiwada Y; Cosentino L M; Liu S H; Pai R B; Cheng Y C; Lee K H
Anti-AIDS (acquired immune deficiency syndrome) agents. 17. New brominated hexahydroxybiphenyl derivatives as potent anti-HIV agents.
Journal of medicinal chemistry 1995;38(16):3003-8.
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1995: Ohnishi S; Fukamiya N; Okano M; Tagahara K; Lee K H
Bruceosides D, E, and F, three new cytotoxic quassinoid glucosides from Brucea javanica.
Journal of natural products 1995;58(7):1032-8.
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1995: Zhang S X; Chen K; Liu X J; Zhang D C; Tao-Wiedmann T W; Leu S L; McPhail A T; Lee K H
The isolation and structural elucidation of three new neolignans, piperulins [corrected] A, B, and C, as platelet activating factor receptor antagonists from Piper puberulum.
Journal of natural products 1995;58(4):540-7.
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1995: Kashiwada Y; Fujioka T; Mihashi K; Marubayashi N; Mizuki K; Chen I S; Lee K H
Antitumor agents, 157. Absolute structures of cumingianosides A-F, antileukemic triterpene glucosides, and structures of the hydrolysates of cumingianoside A.
Journal of natural products 1995;58(4):495-503.
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1994: Bastow K F; Itoigawa M; Furukawa H; Kashiwada Y; Bori I D; Ballas L M; Lee K H
Antiproliferative actions of 7-substituted 1,3-dihydroxyacridones; possible involvement of DNA topoisomerase II and protein kinase C as biochemical targets.
Bioorganic & medicinal chemistry 1994;2(12):1403-11.
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1994: Wang H K; Liu S Y; Hwang K M; Taylor G; Lee K H
Synthesis of novel water-soluble 7-(aminoacylhydrazono)-formyl camptothecins with potent inhibition of DNA topoisomerase I.
Bioorganic & medicinal chemistry 1994;2(12):1397-402.
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1994: Zhang S; Tung-Ling Lee C; Kashiwada Y; Chen K; Zhang D C; Lee K H
Yunantaxusin A, a new 11(15-->1)-abeo-taxane from Taxus yunnanensis.
Journal of natural products 1994;57(11):1580-3.
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1994: Huang L; Kashiwada Y; Cosentino L M; Fan S; Chen C H; McPhail A T; Fujioka T; Mihashi K; Lee K H
Anti-AIDS agents. 15. Synthesis and anti-HIV activity of dihydroseselins and related analogs.
Journal of medicinal chemistry 1994;37(23):3947-55.
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1994: Lee T T; Kashiwada Y; Huang L; Snider J; Cosentino M; Lee K H
Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides.
Bioorganic & medicinal chemistry 1994;2(10):1051-6.
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1994: Li L; Wang H K; Kuo S C; Wu T S; Mauger A; Lin C M; Hamel E; Lee K H
Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents.
Journal of medicinal chemistry 1994;37(20):3400-7.
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1994: Zhang Y L; Tropsha A; McPhail A T; Lee K H
Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy.
Journal of medicinal chemistry 1994;37(10):1460-4.
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1994: Li L; Wang H K; Kuo S C; Wu T S; Lednicer D; Lin C M; Hamel E; Lee K H
Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry 1994;37(8):1126-35.
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1994: Kuo Y H; King M L; Chen C F; Chen H Y; Chen C H; Chen K; Lee K H
Two new macrolide sesquiterpene pyridine alkaloids from Maytenus emarginata: emarginatine G and the cytotoxic emarginatine F.
Journal of natural products 1994;57(2):263-9.
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1994: Fujioka T; Kashiwada Y; Kilkuskie R E; Cosentino L M; Ballas L M; Jiang J B; Janzen W P; Chen I S; Lee K H
Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids.
Journal of natural products 1994;57(2):243-7.
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1994: Zhang Y L; Guo X; Cheng Y C; Lee K H
Antitumor agents. 148. Synthesis and biological evaluation of novel 4 beta-amino derivatives of etoposide with better pharmacological profiles.
Journal of medicinal chemistry 1994;37(4):446-52.
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1994: Zhou X M; Lee K J; Cheng J; Wu S S; Chen H X; Guo X; Cheng Y C; Lee K H
Antitumor agents. 144. New gamma-lactone ring-modified arylamino etoposide analogs as inhibitors of human DNA topoisomerase II.
Journal of medicinal chemistry 1994;37(2):287-92.
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1994: Kashiwada Y; Huang L; Ballas L M; Jiang J B; Janzen W P; Lee K H
New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C.
Journal of medicinal chemistry 1994;37(1):195-200.
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1994: Hu C Q; Chen K; Shi Q; Kilkuskie R E; Cheng Y C; Lee K H
Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids.
Journal of natural products 1994;57(1):42-51.
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1993: Huang B R; Lee K H; Tseng T L; Wang H M; Chen C F; Tzeng C C
Synthetic and cytotoxic studies of alpha-methylene-gamma-butyrolactone bearing pyrimidines.
Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences 1993;9(12):707-11.
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1993: Imamura K; Fukamiya N; Okano M; Tagahara K; Lee K H
Bruceanols D, E, and F three new cytotoxic quassinoids from Brucea antidysenterica.
Journal of natural products 1993;56(12):2091-7.
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1993: Kashiwada Y; Zhang D C; Chen Y P; Cheng C M; Chen H T; Chang H C; Chang J J; Lee K H
Antitumor agents, 145. Cytotoxic asprellic acids A and C and asprellic acid B. new p-coumaroyl triterpenes, from Ilex asprella.
Journal of natural products 1993;56(12):2077-82.
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1993: Konoshima T; Takasaki M; Kozuka M; Haruna M; Ito K; Estes J R; Lee K H
Constituents of rosaceous plants. I. Structure of new triterpenoids from Cowania mexicana.
Chemical & pharmaceutical bulletin 1993;41(9):1612-5.
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1993: Bastow K F; Tatematsu H; Sun L; Fukushima Y; Lee K H
Synthesis and biological evaluation of tetrademethyl isocolchicine derivatives as inhibitors of DNA topoisomerase action in vitro.
Bioorganic & medicinal chemistry 1993;1(3):227-34.
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1993: Li H Y; Sun N J; Kashiwada Y; Sun L; Snider J V; Cosentino L M; Lee K H
Anti-AIDS agents, 9. Suberosol, a new C31 lanostane-type triterpene and anti-HIV principle from Polyalthia suberosa.
Journal of natural products 1993;56(7):1130-3.
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1993: Bastow K F; Bori I D; Fukushima Y; Kashiwada Y; Tanaka T; Nonaka G; Nishioka I; Lee K H
Inhibition of DNA topoisomerases by sanguiin H-6, a cytotoxic dimeric ellagitannin from Sanguisorba officinalis.
Planta medica 1993;59(3):240-5.
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1993: Konoshima T; Terada H; Kokumai M; Kozuka M; Tokuda H; Estes J R; Li L; Wang H K; Lee K H
Studies on inhibitors of skin tumor promotion, XII. Rotenoids from Amorpha fruticosa.
Journal of natural products 1993;56(6):843-8.
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1993: Sun L; Hamel E; Lin C M; Hastie S B; Pyluck A; Lee K H
Antitumor agents. 141. Synthesis and biological evaluation of novel thiocolchicine analogs: N-acyl-, N-aroyl-, and N-(substituted benzyl)deacetylthiocolchicines as potent cytotoxic and antimitotic compounds.
Journal of medicinal chemistry 1993;36(10):1474-9.
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1993: Kashiwada Y; Nonaka G; Nishioka I; Lee K J; Bori I; Fukushima Y; Bastow K F; Lee K H
Tannins as potent inhibitors of DNA topoisomerase II in vitro.
Journal of pharmaceutical sciences 1993;82(5):487-92.
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1993: Sun L; McPhail A T; Hamel E; Lin C M; Hastie S B; Chang J J; Lee K H
Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents.
Journal of medicinal chemistry 1993;36(5):544-51.
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1993: Wang Z Q; Shen Y C; Chen H X; Chang J Y; Guo X; Cheng Y C; Lee K H
Antitumor agents. 126. Novel 4 beta-substituted anilino derivatives of 3',4'-O,O-didemethylpodophyllotoxin as potent inhibitors of human DNA topoisomerase II.
Pharmaceutical research 1993;10(3):343-50.
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1993: Zhou X M; Wang Z Q; Chen H X; Cheng Y C; Lee K H
Antitumor agents. 125. New 4 beta-benzoylamino derivatives of 4'-O-demethyl-4-desoxypodophyllotoxin and 4 beta-benzoyl derivatives of 4'-O-demethylpodophyllotoxin as potent inhibitors of human DNA topoisomerase II.
Pharmaceutical research 1993;10(2):214-9.
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1992: Shi Q; Chen K; Fujioka T; Kashiwada Y; Chang J J; Kozuka M; Estes J R; McPhail A T; McPhail D R; Lee K H
Antitumor agents, 135. Structure and stereochemistry of polacandrin, a new cytotoxic triterpene from Polanisia dodecandra.
Journal of natural products 1992;55(10):1488-97.
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1992: Kashiwada Y; Nonaka G; Nishioka I; Chang J J; Lee K H
Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents.
Journal of natural products 1992;55(8):1033-43.
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1992: Zhang Y L; Shen Y C; Wang Z Q; Chen H X; Guo X; Cheng Y C; Lee K H
Antitumor agents, 130, Novel 4 beta-arylamino derivatives of 3',4'-didemethoxy-3',4'-dioxo-4-deoxypodophyllotoxin as potent inhibitors of human DNA topoisomerase II.
Journal of natural products 1992;55(8):1100-11.
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1992: Wang H K; Xie J X; Chang J J; Hwang K M; Liu S Y; Ballas L M; Jiang J B; Lee K H
Antitumor agents. 134. New shiraiachrome-A- and calphostin-C-related perylene derivatives as cytotoxic and antiviral agents and inhibitors of protein kinase C.
Journal of medicinal chemistry 1992;35(15):2717-21.
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1992: Fukamiya N; Okano M; Miyamoto M; Tagahara K; Lee K H
Antitumor agents, 127. Bruceoside C, a new cytotoxic quassinoid glucoside, and related compounds from Brucea javanica.
Journal of natural products 1992;55(4):468-75.
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1992: Wang Z Q; Hu H; Chen H X; Cheng Y C; Lee K H
Antitumor agents. 124. New 4 beta-substituted aniline derivatives of 6,7-O,O-demethylene-4'-O-demethylpodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II.
Journal of medicinal chemistry 1992;35(5):871-7.
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1992: Hu H; Wang Z Q; Liu S Y; Cheng Y C; Lee K H
Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2'-chloro derivatives of etoposide and 4 beta-(arylamino)-4'-O-demethylpodophyllotoxins.
Journal of medicinal chemistry 1992;35(5):866-71.
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1992: Grippo A A; Hall I H; Kiyokawa H; Muraoka O; Shen Y C; Lee K H
The cytotoxicity of helenalin, its mono and difunctional esters, and related sesquiterpene lactones in murine and human tumor cells.
Drug design and discovery 1992;8(3):191-206.
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1992: Chen K; Shi Q A; Fujioka T; Zhang D C; Hu C Q; Jin J Q; Kilkuskie R E; Lee K H
Anti-AIDS agents, 4. Tripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation.
Journal of natural products 1992;55(1):88-92.
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1991: Sakurai H; Miki T; Imakura Y; Shibuya M; Lee K H
Metal- and photo-induced cleavage of DNA by podophyllotoxin, etoposide, and their related compounds.
Molecular pharmacology 1991;40(6):965-73.
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1991: Zhou X M; Wang Z Q; Chang J Y; Chen H X; Cheng Y C; Lee K H
Antitumor agents. 120. New 4-substituted benzylamine and benzyl ether derivatives of 4'-O-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II.
Journal of medicinal chemistry 1991;34(12):3346-50.
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1991: Grippo A A; Wyrick S D; Lee K H; Shrewsbury R P; Hall I H
Disposition of an antineoplastic sesquiterpene lactone, [3H]-plenolin, in BDF1 mice.
Planta medica 1991;57(4):309-14.
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1991: Wu Y C; Duh C Y; Chang F R; Chang G Y; Wang S K; Chang J J; McPhail D R; McPhail A T; Lee K H
The crystal structure and cytotoxicity of goniodiol-7-monoacetate from Goniothalamus amuyon.
Journal of natural products 1991;54(4):1077-81.
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1991: Matsuzaki T; Fukamiya N; Okano M; Fujita T; Tagahara K; Lee K H
Picrasinoside H, a new quassinoid glucoside, and related compounds from the stem wood of Picrasma ailanthoides.
Journal of natural products 1991;54(3):844-8.
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1991: Wu T S; Lin Y M; Haruna M; Pan D J; Shingu T; Chen Y P; Hsu H Y; Nakano T; Lee K H
Antitumor agents, 119. Kansuiphorins A and B, two novel antileukemic diterpene esters from Euphorbia kansui.
Journal of natural products 1991;54(3):823-9.
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1991: Tatematsu H; Mori M; Yang T H; Chang J J; Lee T T; Lee K H
Cytotoxic principles of Securinega virosa: virosecurinine and viroallosecurinine and related derivatives.
Journal of pharmaceutical sciences 1991;80(4):325-7.
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1991: Tatematsu H; Kilkuskie R E; Corrigan A J; Bodner A J; Lee K H
Anti-AIDS agents, 3. Inhibitory effects of colchicine derivatives on HIV replication in H9 lymphocyte cells.
Journal of natural products 1991;54(2):632-7.
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1991: Hall I H; Lee K H
The effects of alpha-methylene-gamma-lactone purines and pyrimidines on L1210 lymphoid leukemia nucleic acid metabolism.
Anticancer research 1991;11(1):337-42.
-
1990: Toyota T; Fukamiya N; Okano M; Tagahara K; Chang J J; Lee K H
Antitumor agents, 118. The isolation and characterization of bruceanic acid A, its methyl ester, and the new bruceanic acids B, C, and D, from Brucea antidysenterica.
Journal of natural products 1990;53(6):1526-32.
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1990: Wang Z Q; Kuo Y H; Schnur D; Bowen J P; Liu S Y; Han F S; Chang J Y; Cheng Y C; Lee K H
Antitumor agents. 113. New 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II.
Journal of medicinal chemistry 1990;33(9):2660-6.
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1990: Pan D J; Li Z L; Hu C Q; Chen K; Chang J J; Lee K H
The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives.
Planta medica 1990;56(4):383-5.
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1990: Hu C Q; Chang J J; Lee K H
Antitumor agents, 115. Seselidiol, a new cytotoxic polyacetylene from Seseli mairei.
Journal of natural products 1990;53(4):932-5.
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1990: Nozaki H; Matsuura Y; Hirono S; Kasai R; Chang J J; Lee K H
Antitumor agents, 116. Cytotoxic triterpenes from Maytenus diversifolia.
Journal of natural products 1990;53(4):1039-41.
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1990: Lee K H; Beers S A; Mori M; Wang Z Q; Kuo Y H; Li L; Liu S Y; Chang J Y; Han F S; Cheng Y C
Antitumor agents. 111. New 4-hydroxylated and 4-halogenated anilino derivatives of 4'-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II.
Journal of medicinal chemistry 1990;33(5):1364-8.
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1990: Nonaka G; Nishioka I; Nishizawa M; Yamagishi T; Kashiwada Y; Dutschman G E; Bodner A J; Kilkuskie R E; Cheng Y C; Lee K H
Anti-AIDS agents, 2: Inhibitory effects of tannins on HIV reverse transcriptase and HIV replication in H9 lymphocyte cells.
Journal of natural products 1990;53(3):587-95.
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1990: Kuo Y H; Chen C H; Kuo L M; King M L; Wu T S; Haruna M; Lee K H
Antitumor agents, 112. Emarginatine B, a novel potent cytotoxic sesquiterpene pyridine alkaloid from Maytenus emarginata.
Journal of natural products 1990;53(2):422-8.
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1989: Hall I H; Grippo A A; Holbrook D J; Roberts G; Lin H C; Kim H L; Lee K H
Role of thiol agents in protecting against the toxicity of helenalin in tumor-bearing mice.
Planta medica 1989;55(6):513-7.
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1989: Wu T S; Wang M L; Jong T T; McPhail A T; McPhail D R; Lee K H
X-ray crystal structure of acrovestone, a cytotoxic principle from Acronychia pedunculata.
Journal of natural products 1989;52(6):1284-9.
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1989: Yamagishi T; Haruna M; Yan X Z; Chang J J; Lee K H
Antitumor agents, 110. Bryophyllin B, a novel potent cytotoxic bufadienolide from Bryophyllum pinnatum.
Journal of natural products 1989;52(5):1071-9.
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1989: Liu S Y; Hwang B D; Haruna M; Imakura Y; Lee K H; Cheng Y C
Podophyllotoxin analogs: effects on DNA topoisomerase II, tubulin polymerization, human tumor KB cells, and their VP-16-resistant variants.
Molecular pharmacology 1989;36(1):78-82.
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1989: Nishizawa M; Yamagishi T; Dutschman G E; Parker W B; Bodner A J; Kilkuskie R E; Cheng Y C; Lee K H
Anti-AIDS agents, 1. Isolation and characterization of four new tetragalloylquinic acids as a new class of HIV reverse transcriptase inhibitors from tannic acid.
Journal of natural products 1989;52(4):762-8.
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1989: Lee K H; Imakura Y; Haruna M; Beers S A; Thurston L S; Dai H J; Chen C H; Liu S Y; Cheng Y C
Antitumor agents, 107. New cytotoxic 4-alkylamino analogues of 4'-demethyl-epipodophyllotoxin as inhibitors of human DNA topoisomerase II.
Journal of natural products 1989;52(3):606-13.
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1989: Okano M; Fukamiya N; Toyota T; Tagahara K; Lee K H
Antitumor agents, 104. Isolation of yadanziosides M and P from Brucea antidysenterica and identification of bruceantinoside B as a mixture of yadanzioside P and bruceantinoside C.
Journal of natural products 1989;52(2):398-401.
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1989: Thurston L S; Imakura Y; Haruna M; Li D H; Liu Z C; Liu S Y; Cheng Y C; Lee K H
Antitumor agents. 100. Inhibition of human DNA topoisomerase II by cytotoxic ether and ester derivatives of podophyllotoxin and alpha-peltatin.
Journal of medicinal chemistry 1989;32(3):604-8.
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1988: Beers S A; Imakura Y; Dai H J; Li D H; Cheng Y C; Lee K H
Antitumor agents, 99. Synthetic ring C aromatized podophyllotoxin analogues as potential inhibitors of human DNA topoisomerase II.
Journal of natural products 1988;51(5):901-5.
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1988: Lee K H; Lin Y M; Wu T S; Zhang D C; Yamagishi T; Hayashi T; Hall I H; Chang J J; Wu R Y; Yang T H
The cytotoxic principles of Prunella vulgaris, Psychotria serpens, and Hyptis capitata: ursolic acid and related derivatives.
Planta medica 1988;54(4):308-11.
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1988: Yamagishi T; Yan X Z; Wu R Y; McPhail D R; McPhail A T; Lee K H
Structure and stereochemistry of bryophyllin-A, a novel potent cytotoxic bufadienolide orthoacetate from Bryophyllum pinnatum.
Chemical & pharmaceutical bulletin 1988;36(4):1615-7.
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1988: Yokoi T; Yang L M; Yokoi T; Wu R Y; Lee K H
Neihumicin, a new cytotoxic antibiotic from Micromonospora neihuensis. III. Structure-activity relationships.
The Journal of antibiotics 1988;41(4):494-501.
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1988: Yang L M; Wu R Y; McPhail A T; Yokoi T; Lee K H
Neihumicin, a new cytotoxic antibiotic from Micromonospora neihuensis. II. Structural determination and total synthesis.
The Journal of antibiotics 1988;41(4):488-93.
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1988: Wu R Y; Yang L M; Yokoi T; Lee K H
Neihumicin, a new cytotoxic antibiotic from Micromonospora neihuensis. I. The producing organism, fermentation, isolation and biological properties.
The Journal of antibiotics 1988;41(4):481-7.
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1988: Fukamiya N; Okano M; Tagahara K; Aratani T; Lee K H
Antitumor agents, 93. Bruceanol C, a new cytotoxic quassinoid from Brucea antidysenterica.
Journal of natural products 1988;51(2):349-52.
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1988: Williams W L; Hall I H; Grippo A A; Oswald C B; Lee K H; Holbrook D J; Chaney S G
Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia tumor cells by helenalin and bis(helenalinyl)malonate in vivo.
Journal of pharmaceutical sciences 1988;77(2):178-84.
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1988: Hall I H; Williams W L; Grippo A A; Lee K H; Holbrook D J; Chaney S G
Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia cells in culture by sesquiterpene lactones.
Anticancer research 1988;8(1):33-42.
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1987: Hall I H; Grippo A A; Lee K H; Chaney S G; Holbrook D J
Effect of helenalin and bis(helenalinyl)malonate on nucleic acid and protein synthesis in human KB carcinoma cells.
Pharmaceutical research 1987;4(6):509-14.
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1987: Hayashi T; Smith F T; Lee K H
Antitumor agents. 89. Psychorubrin, a new cytotoxic naphthoquinone from Psychotria rubra and its structure-activity relationships.
Journal of medicinal chemistry 1987;30(11):2005-8.
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1987: Fukamiya N; Okano M; Tagahara K; Aratani T; Muramoto Y; Lee K H
Antitumor agents, 90. Bruceantinoside C, a new cytotoxic quassinoid glycoside from Brucea antidysenterica.
Journal of natural products 1987;50(6):1075-9.
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1987: Lee K H; Tani S; Imakura Y
Antimalarial agents, 4. Synthesis of a brusatol analog and biological activity of brusatol-related compounds.
Journal of natural products 1987;50(5):847-51.
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1987: Fukamiya N; Okano M; Aratani T; Negoro K; Lin Y M; Lee K H
Antitumor agents: LXXXVII. Cytotoxic antileukemic canthin-6-one alkaloids from Brucea antidysenterica and the structure activity relationships of their related derivatives.
Planta medica 1987;53(2):140-3.
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1986: Thurston L S; Irie H; Tani S; Han F S; Liu Z C; Cheng Y C; Lee K H
Antitumor agents. 78. Inhibition of human DNA topoisomerase II by podophyllotoxin and alpha-peltatin analogues.
Journal of medicinal chemistry 1986;29(8):1547-50.
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1986: Fukamiya N; Okano M; Aratani T; Negoro K; McPhail A T; Ju-ichi M; Lee K H
Antitumor agents, 79. Cytotoxic antileukemic alkaloids from Brucea antidysenterica.
Journal of natural products 1986;49(3):428-34.
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1985: Lin Y M; Juichi M; Wu R Y; Lee K H
Antitumor agents. LXIX. Alkaloids of Ochrosia acuminata.
Planta medica 1985;(6):545-6.
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1985: Okano M; Fukamiya N; Aratani T; Juichi M; Lee K H
Antitumor agents, 74. Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica.
Journal of natural products 1985;48(6):972-5.
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1985: Hall I H; Williams W L; Chaney S G; Gilbert C J; Holbrook D J; Muraoka O; Kiyokawa H; Lee K H
Antitumor agents 68: effects of a series of helenalin derivatives on P-388 lymphocytic leukemia nucleic acid and protein synthesis.
Journal of pharmaceutical sciences 1985;74(3):250-4.
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1981: Lee K H; Ibuka T; Sims D; Muraoka O; Kiyokawa H; Hall I H; Kim H L
Antitumor agents. 44. Bis(helenalinyl) esters and related derivatives as novel potent antileukemic agents.
Journal of medicinal chemistry 1981;24(8):924-7.
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