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Kok-Onn Lee

Research Profile

Chemicals & Drugs

Geographic Areas

Disorders

Phenomena

Blotting, Western

Anatomy

Tumor Cells, Cultured

Procedures

Physiology

Transcription, Genetic

Living Beings

Asian Continental Ancestry Group

Co-author Network

Publications

TOP 3
Yan Yan Chen; Ying Hua Hu; Kok-Onn Lee; Guang Wei Li; Hui Li; Kah-Yin Loke; Larry Kok-Seng Poh; Karen Mei Ling Tan; Jin Ping Wang; Lin Wang; Raymond Ming En Chan; Yung Seng Lee
The association of a nucleobindin 2 gene (NUCB2) variant with childhood adiposity.
Kai Soo Tan; Sylvie Alonso; Akshamal Mihiranga Gamage; Hui Qi Vanessa Koh; Kok-Onn Lee; Yichun Liu; Kee Chung Low; Gek-Yen Gladys Tan; Yunn-Hwen Gan
Glutathione deficiency in type 2 diabetes impairs cytokine responses and control of intracellular bacteria.
Jian Zhu; Kok-Onn Lee; Li-Ping Su; Lei Ye; Jian-Hua Ma
Thymosin beta 4 ameliorates hyperglycemia and improves insulin resistance of KK Cg-Ay/J mouse.

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All Publications

2013: Yan Yan Chen; Ying Hua Hu; Kok-Onn Lee; Guang Wei Li; Hui Li; Kah-Yin Loke; Larry Kok-Seng Poh; Karen Mei Ling Tan; Jin Ping Wang; Lin Wang; Raymond Ming En Chan; Yung Seng Lee
The association of a nucleobindin 2 gene (NUCB2) variant with childhood adiposity.
Gene 2013;516(1):48-52.
2012: Kai Soo Tan; Sylvie Alonso; Akshamal Mihiranga Gamage; Hui Qi Vanessa Koh; Kok-Onn Lee; Yichun Liu; Kee Chung Low; Gek-Yen Gladys Tan; Yunn-Hwen Gan
Glutathione deficiency in type 2 diabetes impairs cytokine responses and control of intracellular bacteria.
The Journal of clinical investigation 2012;122(6):2289-300.
2012: Jian Zhu; Kok-Onn Lee; Li-Ping Su; Lei Ye; Jian-Hua Ma
Thymosin beta 4 ameliorates hyperglycemia and improves insulin resistance of KK Cg-Ay/J mouse.
Diabetes research and clinical practice 2012;96(1):53-9.
2012: Xiao-Fei Su; Rui Sun; Jin-Dan Wu; Xiao-Hua Xu; Lei Ye; Li-Yuan Fu; Kok-Onn Lee; Hui-Qin Li; Jian-Hua Ma
Fulminant type 1 diabetes mellitus: a study of nine cases.
Diabetes technology & therapeutics 2012;14(4):325-9.
2011: Yong-Chiat Wong; Meng-Kwoon Sim; Kok-Onn Lee
Des-aspartate-angiotensin-I and angiotensin IV improve glucose tolerance and insulin signalling in diet-induced hyperglycaemic mice.
Biochemical pharmacology 2011;82(9):1198-208.
2011: Juliana C N Chan; Siew Pheng Chan; Chaicharn Deerochanawong; Ruby T Go; Kok-Onn Lee; Ronald Ching-Wan Ma; Chang-Yu Pan; Wayne H-H Sheu; Philip Barter
Diabetic dyslipidaemia in Asian populations in the Western Pacific Region: what we know and don't know.
Diabetes research and clinical practice 2011;94(1):1-13.
2011: Jin-dan Wu; Xiao-hua Xu; Jian Zhu; Bo Ding; Tong-xin Du; Gu Gao; Xiao-ming Mao; Lei Ye; Kok-Onn Lee; Jian-hua Ma
Effect of exenatide on inflammatory and oxidative stress markers in patients with type 2 diabetes mellitus.
Diabetes technology & therapeutics 2011;13(2):143-8.
2011: Yue Zhou; Roy Calne; Shu Uin Gan; Kok-Onn Lee; Yan Ting Lim; Gen Lin; Jeyakumar Masilamani; Fatimah Bte Mustafa; Toan-Thang Phan; Meow Ling Phua; Laura Rivino; Paul A MacAry
Characterization of human umbilical cord lining-derived epithelial cells and transplantation potential.
Cell transplantation 2011;20(11-12):1827-41.
2010: Roy Y Calne; Shu Uin Gan; Kok-Onn Lee
Stem cell and gene therapies for diabetes mellitus.
Nature reviews. Endocrinology 2010;6(3):173-7.
2010: Li Feng; Yong-feng Song; Qing-bo Guan; Hong-jun Liu; Bo Ban; Hai-xin Dong; Xiao-lei Hou; Kok-Onn Lee; Ling Gao; Jia-jun Zhao
Long-term ethanol exposure inhibits glucose transporter 4 expression via an AMPK-dependent pathway in adipocytes.
Acta pharmacologica Sinica 2010;31(3):329-40.
2009: Lei Ye; Kok-Onn Lee; L P Su; W C Toh; Husnain Khawaja Haider; Peter K Law; W Zhang; Siew-Pang Chan; Eugene K W Sim
Skeletal myoblast transplantation for attenuation of hyperglycaemia, hyperinsulinaemia and glucose intolerance in a mouse model of type 2 diabetes mellitus.
Diabetologia 2009;52(9):1925-34.
2009: Shih Ling Kao; Cheng-Leng Chan; Belinda Tan; CC Tchoyoson Lim; Rinkoo Dalan; Daphne Gardner; Edward Pratt; Marilyn Lee; Kok-Onn Lee
An unusual outbreak of hypoglycemia--a correction.
The New England journal of medicine 2009;360(23):2482-3.
2009: Shih Ling Kao; Cheng-Leng Chan; Belinda Tan; CC Tchoyoson Lim; Rinkoo Dalan; Daphne Gardner; Edward Pratt; Marilyn Lee; Kok-Onn Lee
An unusual outbreak of hypoglycemia.
The New England journal of medicine 2009;360(7):734-6.
2007: Jian-jun Dong; Jia-jun Zhao; Kok-Onn Lee; Min-chen Lir; Shzu-Wei Chan; Lin Liao
[Distribution of polymorphism in endothelial nitric oxide synthase gene in Singapore Chinese and its association with diabetic nephropathy].
Zhonghua yi xue za zhi 2007;87(48):3415-7.
2007: Meng-Kwoon Sim; Xiao-Guang Xu; Yong-Chiat Wong; Sai-Zhen Sim; Kok-Onn Lee
Des-aspartate-angiotensin I exerts hypoglycemic action via glucose transporter-4 translocation in type 2 diabetic KKAy mice and GK rats.
Endocrinology 2007;148(12):5925-32.
2007: Francis L W Ho; Choon Fong Liew; Elaine C Cunanan; Kok-Onn Lee
Oral hypoglycaemic agents for diabetes in pregnancy - an appraisal of the current evidence for oral anti-diabetic drug use in pregnancy.
Annals of the Academy of Medicine, Singapore 2007;36(8):672-8.
2007: B Starling Emerald; Yong Chen; Tao Zhu; Zhe Zhu; Kok-Onn Lee; Peter D Gluckman; Peter E Lobie
AlphaCP1 mediates stabilization of hTERT mRNA by autocrine human growth hormone.
The Journal of biological chemistry 2007;282(1):680-90.
2006: Lin Liao; Min Chin Lim; Shzu-Wei Chan; Jia-Jun Zhao; Kok-Onn Lee
Nitric oxide synthase gene polymorphisms and nephropathy in Asians with Type 2 diabetes.
Journal of diabetes and its complications 2006;20(6):371-5.
2006: Xin Zhang; B Starling Emerald; Svetlana Mukhina; Kumarasamypet M Mohankumar; Astrid Kraemer; Alpha S Yap; Peter D Gluckman; Kok-Onn Lee; Peter E Lobie
HOXA1 is required for E-cadherin-dependent anchorage-independent survival of human mammary carcinoma cells.
The Journal of biological chemistry 2006;281(10):6471-81.
2006: F Tan; T Q Nam; Kok-Onn Lee; Wei-Keat Cheah; Jagat J Mukherjee
Recurrent episodes of arthritis in a hyperthyroid patient.
Singapore medical journal 2006;47(2):163-5.
2005: Jagat J Mukherjee; Michael L Villa; Lenny Tan; Kok-Onn Lee
Bilateral adrenal masses due to histoplasmosis.
The Journal of clinical endocrinology and metabolism 2005;90(12):6725-6.
2005: Qiang Wan; Yi Liu; Qingbo Guan; Ling Gao; Kok-Onn Lee; Jiajun Zhao
Ethanol feeding impairs insulin-stimulated glucose uptake in isolated rat skeletal muscle: role of Gs alpha and cAMP.
Alcoholism, clinical and experimental research 2005;29(8):1450-6.
2005: Wei-Keat Cheah; Abu Rauff; Kok-Onn Lee; W Tan
Parathyroid carcinoma: a case series.
Annals of the Academy of Medicine, Singapore 2005;34(7):443-6.
2005: Zhe Zhu; Svetlana Mukhina; Tao Zhu; Hichem C Mertani; Kok-Onn Lee; Peter E Lobie
p44/42 MAP kinase-dependent regulation of catalase by autocrine human growth hormone protects human mammary carcinoma cells from oxidative stress-induced apoptosis.
Oncogene 2005;24(23):3774-85.
2005: Choon Fong Liew; Stephen D Wise; Kwee Poo Yeo; Kok-Onn Lee
Insulin-like growth factor binding protein-1 is independently affected by ethnicity, insulin sensitivity, and leptin in healthy, glucose-tolerant young men.
The Journal of clinical endocrinology and metabolism 2005;90(3):1483-8.
2005: Tao Zhu; B Starling-Emerald; Xin Zhang; Kok-Onn Lee; Peter D Gluckman; Hichem C Mertani; Peter E Lobie
Oncogenic transformation of human mammary epithelial cells by autocrine human growth hormone.
Cancer research 2005;65(1):317-24.
2004: Svetlana Mukhina; Hichem C Mertani; Ke Guo; Kok-Onn Lee; Peter D Gluckman; Peter E Lobie
Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormone.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(42):15166-71.
2004: Kok-Onn Lee; L Liao; Jagat J Mukherjee
Does growth hormone prevent aging in the healthy elderly with low serum insulin-like growth factor-I ?
Mechanisms of ageing and development 2004;125(4):291-5.
2004: Michael L Villa; Jagat J Mukherjee; Nam Q Tran; Wei-Keat Cheah; H S Howe; Kok-Onn Lee
Anaplastic thyroid carcinoma with destructive thyrotoxicosis in a patient with preexisting multinodular goiter.
Thyroid : official journal of the American Thyroid Association 2004;14(3):227-30.
2003: Choon Fong Liew; E-S Seah; K-P Yeo; Kok-Onn Lee; Stephen D Wise
Lean, nondiabetic Asian Indians have decreased insulin sensitivity and insulin clearance, and raised leptin compared to Caucasians and Chinese subjects.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2003;27(7):784-9.
2003: Xin Zhang; Tao Zhu; Yong Chen; Hichem C Mertani; Kok-Onn Lee; Peter E Lobie
Human growth hormone-regulated HOXA1 is a human mammary epithelial oncogene.
The Journal of biological chemistry 2003;278(9):7580-90.
2002: Ralph Graichen; DongXu Liu; Yi Sun; Kok-Onn Lee; Peter E Lobie
Autocrine human growth hormone inhibits placental transforming growth factor-beta gene transcription to prevent apoptosis and allow cell cycle progression of human mammary carcinoma cells.
The Journal of biological chemistry 2002;277(29):26662-72.
2002: Tao Li; Thanh H Vu; Kok-Onn Lee; Youwen Yang; Chuyen V Nguyen; Huy Q Bui; Zhi-Lan Zeng; Binh T Nguyen; Ji-Fan Hu; Susan Murphy; Randy L Jirtle; Andrew R Hoffman
An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa.
The Journal of biological chemistry 2002;277(16):13518-27.
2001: Hichem C Mertani; Tao Zhu; Eyleen L K Goh; Kok-Onn Lee; Gérard Morel; Peter E Lobie
Autocrine human growth hormone (hGH) regulation of human mammary carcinoma cell gene expression. Identification of CHOP as a mediator of hGH-stimulated human mammary carcinoma cell survival.
The Journal of biological chemistry 2001;276(24):21464-75.
2001: X Zhou; Kah-Yin Loke; C C Pillai; H K How; Hui-Kim Yap; Kok-Onn Lee
IGFs and IGF-binding proteins in short children with steroid-dependent nephrotic syndrome on chronic glucocorticoids: changes with 1 year exogenous GH.
European journal of endocrinology / European Federation of Endocrine Societies 2001;144(3):237-43.
2001: KK Kaulsay; Tao Zhu; W Bennett; Kok-Onn Lee; Peter E Lobie
The effects of autocrine human growth hormone (hGH) on human mammary carcinoma cell behavior are mediated via the hGH receptor.
Endocrinology 2001;142(2):767-77.
2000: KK Kaulsay; Hichem C Mertani; Kok-Onn Lee; Peter E Lobie
Autocrine human growth hormone enhancement of human mammary carcinoma cell spreading is Jak2 dependent.
Endocrinology 2000;141(4):1571-84.
1999: KK Kaulsay; Hichem C Mertani; Jan Törnell; Gérard Morel; Kok-Onn Lee; Peter E Lobie
Autocrine stimulation of human mammary carcinoma cell proliferation by human growth hormone.
Experimental cell research 1999;250(1):35-50.
1999: H K How; A E J Yeoh; Thuan-Chong Quah; Y Oh; Ronald G Rosenfeld; Kok-Onn Lee
Insulin-like growth factor binding proteins (IGFBPs) and IGFBP-related protein 1-levels in cerebrospinal fluid of children with acute lymphoblastic leukemia.
The Journal of clinical endocrinology and metabolism 1999;84(4):1283-7.
1999: KK Kaulsay; Erg-Hen Ng; CY Ji; Gay Hui Ho; Tar-Choon Aw; Kok-Onn Lee
Serum IGF-binding protein-6 and prostate specific antigen in breast cancer.
European journal of endocrinology / European Federation of Endocrine Societies 1999;140(2):164-8.
1998: Z R Miao; T K Lin; T A Bongso; X Zhou; P Cohen; Kok-Onn Lee
Effect of insulin-like growth factors (IGFs) and IGF-binding proteins on in vitro sperm motility.
Clinical endocrinology 1998;49(2):235-9.
1998: Gay Hui Ho; CY Ji; B H Phang; Kok-Onn Lee; Khee Chee Soo; Erg-Hen Ng
Tamoxifen alters levels of serum insulin-like growth factors and binding proteins in postmenopausal breast cancer patients: a prospective paired cohort study.
Annals of surgical oncology 1998;5(4):361-7.
1998: Erg-Hen Ng; CY Ji; P H Tan; V Lin; Khee Chee Soo; Kok-Onn Lee
Altered serum levels of insulin-like growth-factor binding proteins in breast cancer patients.
Annals of surgical oncology 1998;5(2):194-201.
1997: Kah-Yin Loke; Hui-Kim Yap; X Zhou; Siew-Peng Tan; SM Chao; Kok-Onn Lee
Efficacy and safety of one year of growth hormone therapy in steroid-dependent nephrotic syndrome.
The Journal of pediatrics 1997;130(5):793-9.
1997: Kok-Onn Lee; Thuan-Chong Quah
Living, dying, death and advance directives.
Singapore medical journal 1997;38(4):141-2.
1996: Soon Chye Ng; Kok-Onn Lee
Treatment of male infertility with growth hormone.
Clinical science (London, England : 1979) 1996;91(3):254-5.
1995: E S Ang; H S Teh; F X Sundram; Kok-Onn Lee
Effect of lithium and oral thyrotrophin-releasing hormone (TRH) on serum thyrotrophin (TSH) and radioiodine uptake in patients with well differentiated thyroid carcinoma.
Singapore medical journal 1995;36(6):606-8.
1995: Kok-Onn Lee; Luca Persani; M Tan; F X Sundram; Paolo Beck-Peccoz
Thyrotropin with decreased biological activity, a delayed consequence of cranial irradiation for nasopharyngeal carcinoma.
Journal of endocrinological investigation 1995;18(10):800-5.
1995: Kok-Onn Lee; Soon Chye Ng; P S Lee; Ariff Bongso; E A Taylor; T K Lin; SS Ratnam
Effect of growth hormone therapy in men with severe idiopathic oligozoospermia.
European journal of endocrinology / European Federation of Endocrine Societies 1995;132(2):159-62.
1995: Bee Wah Lee; J Tan; Hui-Kim Yap; S C Wong; K S Poh; Kok-Onn Lee
Restriction fragment length polymorphism of the T cell receptor beta-chain gene in Chinese patients with thyrotoxic hypokaleamic periodic paralysis and Graves' disease.
Autoimmunity 1995;21(4):241-4.
1994: Kok-Onn Lee; Y Oh; Linda C Giudice; P Cohen; D M Peehl; Ronald G Rosenfeld
Identification of insulin-like growth factor-binding protein-3 (IGFBP-3) fragments and IGFBP-5 proteolytic activity in human seminal plasma: a comparison of normal and vasectomized patients.
The Journal of clinical endocrinology and metabolism 1994;79(5):1367-72.
1993: J S Cheah; F X Sundram; Kok-Onn Lee; A Rauff
Thyroid disorders in Singapore.
Annals of the Academy of Medicine, Singapore 1993;22(4):537-8.
1991: Kok-Onn Lee; E A Taylor; V M Oh; J S Cheah; S E Aw
Hyperinsulinaemia in thyrotoxic hypokalaemic periodic paralysis.
Lancet 1991;337(8749):1063-4.
1990: J H Lee; T K Lin; S L Lam; Kok-Onn Lee
The pattern of diabetes in a primary health care setting in Singapore.
Annals of the Academy of Medicine, Singapore 1990;19(4):447-51.
1990: V M Oh; E A Taylor; S H Yeo; Kok-Onn Lee
Cation transport across lymphocyte plasma membranes in euthyroid and thyrotoxic men with and without hypokalaemic periodic paralysis.
Clinical science (London, England : 1979) 1990;78(2):199-206.
1990: Kok-Onn Lee; D Y Chua; J S Cheah
Oestrogen and progesterone receptors in men with bilateral or unilateral pubertal macromastia.
Clinical endocrinology 1990;32(1):101-5.
1989: Kok-Onn Lee
The role of ultrasensitive thyroid-stimulating hormone measurement in the initial evaluation of thyroid function.
Annals of the Academy of Medicine, Singapore 1989;18(4):398-403.