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Moses Lee
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Research Profile (preview)
Chemicals & Drugs
Phenomena
Procedures
Concepts & Ideas
Anatomy
Disorders
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Network (preview)
40
Hartley, John
14
Wilson, David W.
11
Kiakos, Konstantinos
11
Nguyen, Binh
11
O'Hare, Caroline
8
Brown, Toni
7
Buchmueller, Karen
7
Mackay, Hilary
6
Hochhauser, Daniel
6
kluza, jerome
5
Howard, Cameron
5
Handl, Heather
5
Summerville, Kaitlin
4
Taherbhai, Zarmeen
4
Townes, Heather
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All Publications
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2009: Westrate Laura; Mackay Hilary; Brown Toni; Nguyen Binh; Kluza Jerome; Wilson W David; Lee Moses; Hartley John A
Effects of the N-terminal acylamido group of imidazole- and pyrrole-containing polyamides on DNA sequence specificity and binding affinity.
Biochemistry 2009;48(24):5679-88.
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2008: Mackay Hilary; Brown Toni; Uthe Peter B; Westrate Laura; Sielaff Alan; Jones Justin; Lajiness James P; Kluza Jerome; O'Hare Caroline; Nguyen Binh; Davis Zach; Bruce Chrystal; Wilson W David; Hartley John A; Lee Moses
Sequence specific and high affinity recognition of 5'-ACGCGT-3' by rationally designed pyrrole-imidazole H-pin polyamides: thermodynamic and structural studies.
Bioorganic & medicinal chemistry 2008;16(20):9145-53.
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2008: Brown Toni; Mackay Hilary; Turlington Mark; Sutterfield Arden; Smith Traci; Sielaff Alan; Westrate Laura; Bruce Chrystal; Kluza Jerome; O'Hare Caroline; Nguyen Binh; Wilson W David; Hartley John A; Lee Moses
Modifying the N-terminus of polyamides: PyImPyIm has improved sequence specificity over f-ImPyIm.
Bioorganic & medicinal chemistry 2008;16(9):5266-76.
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2008: Mackay Hilary; Brown Toni; Sexton Jim S; Kotecha Minal; Nguyen Binh; Wilson W David; Kluza Jerome; Savic Boris; O'Hare Caroline; Hochhauser Daniel; Lee Moses; Hartley John A
Targeting the inverted CCAAT Box-2 of the topoisomerase IIalpha gene: DNA sequence selective recognition by a polyamide-intercalator as a staggered dimer.
Bioorganic & medicinal chemistry 2008;16(4):2093-102.
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2008: Zhong Haizhen; Kirschner Karl N; Lee Moses; Bowen J Phillip
Binding free energy calculation for duocarmycin/DNA complex based on the QPLD-derived partial charge model.
Bioorganic & medicinal chemistry letters 2008;18(2):542-5.
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2007: Kiakos Konstantinos; Sato Atsushi; Asao Tetsuji; McHugh Peter J; Lee Moses; Hartley John A
DNA sequence selective adenine alkylation, mechanism of adduct repair, and in vivo antitumor activity of the novel achiral seco-amino-cyclopropylbenz[e]indolone analogue of duocarmycin AS-I-145.
Molecular cancer therapeutics 2007;6(10):2708-18.
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2007: O'Hare C Caroline; Uthe Peter; Mackay Hilary; Blackmon Kevin; Jones Justin; Brown Toni; Nguyen Binh; Wilson W David; Lee Moses; Hartley John A
Sequence recognition in the minor groove of DNA by covalently linked formamido imidazole-pyrrole-imidazole polyamides: effect of H-pin linkage and linker length on selectivity and affinity.
Biochemistry 2007;46(42):11661-70.
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2007: Hochhauser Daniel; Kotecha Minal; O'hare Caroline; Morris Peter J; Hartley Janet M; Taherbhai Zarmeen; Harris Dorothy; Forni Claudia; Mantovani Roberto; Lee Moses; Hartley John A
Modulation of topoisomerase IIalpha expression by a DNA sequence-specific polyamide.
Molecular cancer therapeutics 2007;6(1):346-54.
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2007: Brown Toni; Taherbhai Zarmeen; Sexton Jim; Sutterfield Arden; Turlington Mark; Jones Justin; Stallings Lindsay; Stewart Michelle; Buchmueller Karen; Mackay Hilary; O'hare Caroline; Kluza Jerome; Nguyen Binh; Wilson David; Lee Moses; Hartley John A
Synthesis and biophysical evaluation of minor-groove binding C-terminus modified pyrrole and imidazole triamide analogs of distamycin.
Bioorganic & medicinal chemistry 2007;15(1):474-83.
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2006: Le N Minh; Sielaff Alan M; Cooper Amanda J; Mackay Hilary; Brown Toni; Kotecha Minal; O'Hare Caroline; Hochhauser Daniel; Lee Moses; Hartley John A
Binding of f-PIP, a pyrrole- and imidazole-containing triamide, to the inverted CCAAT box-2 of the topoisomerase IIalpha promoter and modulation of gene expression in cells.
Bioorganic & medicinal chemistry letters 2006;16(24):6161-4.
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2006: Buchmueller Karen L; Bailey Suzanna L; Matthews David A; Taherbhai Zarmeen T; Register Janna K; Davis Zachary S; Bruce Chrystal D; O'Hare Caroline; Hartley John A; Lee Moses
Physical and structural basis for the strong interactions of the -ImPy- central pairing motif in the polyamide f-ImPyIm.
Biochemistry 2006;45(45):13551-65.
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2006: Flores Lloyd V; Staples Andrew M; Mackay Hilary; Howard Cameron M; Uthe Peter B; Sexton Jim S; Buchmueller Karen L; Wilson W David; O'Hare Caroline; Kluza Jerome; Hochhauser Daniel; Hartley John A; Lee Moses
Synthesis and evaluation of an intercalator-polyamide hairpin designed to target the inverted CCAAT box 2 in the topoisomerase IIalpha promoter.
Chembiochem : a European journal of chemical biology 2006;7(11):1722-9.
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2006: Purnell Bethany; Sato Atsushi; O'kelley Amanda; Price Carly; Summerville Kaitlin; Hudson Stephen; O'hare Caroline; Kiakos Konstantinos; Asao Tetsuji; Lee Moses; Hartley John A
DNA interstrand crosslinking agents: synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD).
Bioorganic & medicinal chemistry letters 2006;16(21):5677-81.
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2006: Purnell Bethany; Lingerfelt Brian; Scott Adrienne; Townes Heather; Summerville Kaitlin; Hudson Stephen; Kiakos Konstantinos; Hartley John A; Lee Moses
Novel (S)-(-)- and R-(+)-seco-iso-cyclopropylfurano[e]indoline-5,6,7-trimethoxyindole-2-carboxamide (iso-CFI) analogs of duocarmycin C2: synthesis and biological evaluation.
Medicinal chemistry (Shariqah (United Arab Emirates)) 2006;2(2):139-46.
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2005: Buchmueller Karen L; Taherbhai Zarmeen; Howard Cameron M; Bailey Suzanna L; Nguyen Binh; O'Hare Caroline; Hochhauser Daniel; Hartley John A; Wilson W David; Lee Moses
Design of a hairpin polyamide, ZT65B, for targeting the inverted CCAAT box (ICB) site in the multidrug resistant (MDR1) gene.
Chembiochem : a European journal of chemical biology 2005;6(12):2305-11.
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2005: LeBlanc Regan; Dickson John; Brown Toni; Stewart Michelle; Pati Hari N; VanDerveer Don; Arman Hadi; Harris Jeff; Pennington William; Holt Herman L; Lee Moses
Synthesis and cytotoxicity of epoxide and pyrazole analogs of the combretastatins.
Bioorganic & medicinal chemistry 2005;13(21):6025-34.
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2005: Sato Atsushi; McNulty Luanne; Cox Kari; Kim Susan; Scott Adrienne; Daniell Kristen; Summerville Kaitlin; Price Carly; Hudson Stephen; Kiakos Konstantinos; Hartley John A; Asao Tetsuji; Lee Moses
A novel class of in vivo active anticancer agents: achiral seco-amino- and seco-hydroxycyclopropylbenz[e]indolone (seco-CBI) analogues of the duocarmycins and CC-1065.
Journal of medicinal chemistry 2005;48(11):3903-18.
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2005: Price Carly A; Lingerfelt Brian M; Handl Heather L; Kiakos Konstantinos; Hartley John A; Lee Moses
Sequence specific recognition of DNA by tailor-made hairpin conjugates of achiral seco-cyclopropaneindoline-2-benzofurancarboxamide and pyrrole-imidazole polyamides.
Bioorganic & medicinal chemistry letters 2005;15(12):3151-6.
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2005: Toth James L; Trzupek John D; Flores Lloyd V; Kiakos Konstantinos; Hartley John A; Pennington William T; Lee Moses
A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies.
Medicinal chemistry (Shariqah (United Arab Emirates)) 2005;1(1):13-9.
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2005: Buchmueller Karen L; Staples Andrew M; Howard Cameron M; Horick Sarah M; Uthe Peter B; Le N Minh; Cox Kari K; Nguyen Binh; Pacheco Kimberly A O; Wilson W David; Lee Moses
Extending the language of DNA molecular recognition by polyamides: unexpected influence of imidazole and pyrrole arrangement on binding affinity and specificity.
Journal of the American Chemical Society 2005;127(2):742-50.
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2005: Daniell Kristen; Stewart Michelle; Madsen Erik; Le Minh; Handl Heather; Brooks Natalie; Kiakos Konstantinos; Hartley John A; Lee Moses
Design, synthesis, and biological evaluation of achiral analogs of duocarmycin SA.
Bioorganic & medicinal chemistry letters 2005;15(1):177-80.
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2005: Buchmueller Karen L; Staples Andrew M; Uthe Peter B; Howard Cameron M; Pacheco Kimberly A O; Cox Kari K; Henry James A; Bailey Suzanna L; Horick Sarah M; Nguyen Binh; Wilson W David; Lee Moses
Molecular recognition of DNA base pairs by the formamido/pyrrole and formamido/imidazole pairings in stacked polyamides.
Nucleic acids research 2005;33(3):912-21.
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2004: Kupchinsky Stanley; Centioni Sara; Howard Tiffany; Trzupek John; Roller Shane; Carnahan Virginia; Townes Heather; Purnell Bethany; Price Carly; Handl Heather; Summerville Kaitlin; Johnson Kimberly; Toth James; Hudson Stephen; Kiakos Konstantinos; Hartley John A; Lee Moses
A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties.
Bioorganic & medicinal chemistry 2004;12(23):6221-36.
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2004: Henry James A; Le N Minh; Nguyen Binh; Howard Cameron M; Bailey Suzanna L; Horick Sarah M; Buchmueller Karen L; Kotecha Minal; Hochhauser Daniel; Hartley John A; Wilson W David; Lee Moses
Targeting the inverted CCAAT box 2 in the topoisomerase IIalpha promoter by JH-37, an imidazole-pyrrole polyamide hairpin: design, synthesis, molecular biology, and biophysical studies.
Biochemistry 2004;43(38):12249-57.
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2004: Pati Hari; Howard Tiffany; Townes Heather; Lingerfelt Brian; McNulty LuAnne; Lee Moses
Unexpected syntheses of seco-cyclopropyltetrahydroquinolines - from a radical 5-exo-trig cyclization reaction: analogs of CC-1065 and the duocarmycins.
Molecules (Basel, Switzerland) 2004;9(3):125-33.
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2004: Lacy Eilyn R; Nguyen Binh; Le Minh; Cox Kari K; OHare Caroline; Hartley John A; Lee Moses; Wilson W David
Energetic basis for selective recognition of T*G mismatched base pairs in DNA by imidazole-rich polyamides.
Nucleic acids research 2004;32(6):2000-7.
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2002: Kiakos Konstantinos; Howard Tiffany T; Lee Moses; Hartley John A; McHugh Peter J
Saccharomyces cerevisiae RAD5 influences the excision repair of DNA minor groove adducts.
The Journal of biological chemistry 2002;277(46):44576-81.
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2002: Howard Tiffany T; Lingerfelt Brian M; Purnell Bethany L; Scott Adrienne E; Price Carly A; Townes Heather M; McNulty LuAnne; Handl Heather L; Summerville Kaitlin; Hudson Stephen J; Bowen J Phillip; Kiakos Konstantinos; Hartley John A; Lee Moses
Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues.
Bioorganic & medicinal chemistry 2002;10(9):2941-52.
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2002: Toth James L; Price Carly A; Madsen Erik C; Handl Heather L; Hudson Stephen J; Hubbard Richard B; Bowen J Phillip; Kiakos Konstantinos; Hartley John A; Lee Moses
Sequence selective recognition of DNA by hairpin conjugates of a racemic seco-cyclopropaneindoline-2-benzofurancarboxamide and polyamides.
Bioorganic & medicinal chemistry letters 2002;12(16):2245-8.
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2002: Lacy Eilyn R; Cox Kari K; Wilson W David; Lee Moses
Recognition of T*G mismatched base pairs in DNA by stacked imidazole-containing polyamides: surface plasmon resonance and circular dichroism studies.
Nucleic acids research 2002;30(8):1834-41.
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2002: Lacy Eilyn R; Le N Minh; Price Carly A; Lee Moses; Wilson W David
Influence of a terminal formamido group on the sequence recognition of DNA by polyamides.
Journal of the American Chemical Society 2002;124(10):2153-63.
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2000: Brooks N; McHugh P J; Lee M; Hartley J A
Alteration in the choice of DNA repair pathway with increasing sequence selective DNA alkylation in the minor groove.
Chemistry & biology 2000;7(9):659-68.
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2000: Kirschner K N; Lee M; Stanley R C; Bowen J P
Density functional and Ab initio studies on N-acetylduocarmycin SA: insight into its DNA interaction properties.
Bioorganic & medicinal chemistry 2000;8(2):329-35.
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1999: Brooks N; McHugh P J; Lee M; Hartley J A
The role of base excision repair in the repair of DNA adducts formed by a series of nitrogen mustard-containing analogues of distamycin of increasing binding site size.
Anti-cancer drug design 1999;14(1):11-8.
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1997: Brooks N; Lee M; Wright S R; Woo S; Centioni S; Hartley J A
Synthesis, DNA binding, cytotoxicity and sequence specificity of a series of imidazole-containing analogs of the benzoic acid mustard distamycin derivative tallimustine containing an alkylating group at the C-terminus.
Anti-cancer drug design 1997;12(7):591-606.
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1997: Brooks N; Hartley J A; Simpson J E; Wright S R; Woo S; Centioni S; Fontaine M D; McIntyre T E; Lee M
Structure-activity relationship of a series of C-terminus modified aminoalkyl, diaminoalkyl- and anilino-containing analogues of the benzoic acid mustard distamycin derivative tallimustine: synthesis, DNA binding and cytotoxicity studies.
Bioorganic & medicinal chemistry 1997;5(8):1497-507.
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1997: Wyatt M D; Lee M; Hartley J A
The sequence specificity of alkylation for a series of benzoic acid mustard and imidazole-containing distamycin analogues: the importance of local sequence conformation.
Nucleic acids research 1997;25(12):2359-64.
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1997: Wyatt M D; Lee M; Hartley J A
Alkylation specificity for a series of distamycin analogues that tether chlorambucil.
Anti-cancer drug design 1997;12(1):49-60.
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1995: Wyatt M D; Lee M; Garbiras B J; Souhami R L; Hartley J A
Sequence specificity of alkylation for a series of nitrogen mustard-containing analogues of distamycin of increasing binding site size: evidence for increased cytotoxicity with enhanced sequence specificity.
Biochemistry 1995;34(40):13034-41.
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1995: Hartley J A; Webber J; Wyatt M D; Bordenick N; Lee M
Novel cytotoxic DNA sequence and minor groove targeted photosensitizers: conjugates of pyrene and netropsin analogues.
Bioorganic & medicinal chemistry 1995;3(6):623-9.
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1995: Forrow S M; Lee M; Souhami R L; Hartley J A
The effect of AT and GC sequence specific minor groove-binding agents on restriction endonuclease activity.
Chemico-biological interactions 1995;96(2):125-42.
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1995: Hartley J A; Preti C S; Wyatt M D; Lee M
Design, synthesis and biological evaluation of benzoic acid mustard derivatives of imidazole-containing and C-terminal carboxamide analogues of distamycin.
Drug design and discovery 1995;12(4):323-35.
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1994: Wyatt M D; Garbiras B J; Haskell M K; Lee M; Souhami R L; Hartley J A
Structure-activity relationship of a series of nitrogen mustard- and pyrrole-containing minor groove-binding agents related to distamycin.
Anti-cancer drug design 1994;9(6):511-25.
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1994: Lee M; Preti C S; Vinson E; Wyatt M D; Hartley J A
GC sequence specific recognition by an N-formamido, C-terminus-modified and imidazole-containing analogue of netropsin.
Journal of medicinal chemistry 1994;37(24):4073-5.
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1994: Hartley J A; McAdam S R; Das S; Roldan M C; Haskell M K; Lee M
Molecular and cellular pharmacology of novel photoactive psoralen and coumarin conjugates of pyrrole- and imidazole-containing analogues of netropsin.
Anti-cancer drug design 1994;9(3):181-97.
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1994: Lee M; Roldan M C; Haskell M K; McAdam S R; Hartley J A
In vitro photoinduced cytotoxicity and DNA binding properties of psoralen and coumarin conjugates of netropsin analogues: DNA sequence-directed alkylation and cross-link formation.
Journal of medicinal chemistry 1994;37(8):1208-13.
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1993: Lee M; Rhodes A L; Wyatt M D; Forrow S; Hartley J A
Design, synthesis, and biological evaluation of DNA sequence and minor groove selective alkylating agents.
Anti-cancer drug design 1993;8(3):173-92.
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1993: Lee M; Rhodes A L; Wyatt M D; Forrow S; Hartley J A
GC base sequence recognition by oligo(imidazolecarboxamide) and C-terminus-modified analogues of distamycin deduced from circular dichroism, proton nuclear magnetic resonance, and methidiumpropylethylenediaminetetraacetate-iron(II) footprinting studies.
Biochemistry 1993;32(16):4237-45.
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1993: Lee M; Rhodes A L; Wyatt M D; D'Incalci M; Forrow S; Hartley J A
In vitro cytotoxicity of GC sequence directed alkylating agents related to distamycin.
Journal of medicinal chemistry 1993;36(7):863-70.
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