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Michael Lee

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João Paulo L Daher; Ted M Dawson; Valina Dawson; Dagmar Galter; Sandra Gellhaar; Michael K Lee; Alessandra Musso; Olga Pletnikova; Juan C Troncoso; Saskia Biskup; Darren J Moore
Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.
Paul J Tuite; Andrew E Tyan; Michael Garwood; Michael K Lee; Silvia Mangia; Shalom Michaeli
Magnetization transfer and adiabatic R 1ρ MRI in the brainstem of Parkinson's disease.
Emanuela Colla; Philippe Coune; Takeshi Iwatsubo; Ying Liu; Olga Pletnikova; Bernard L Schneider; Juan C Troncoso; Michael K Lee
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo.

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2012: João Paulo L Daher; Ted M Dawson; Valina Dawson; Dagmar Galter; Sandra Gellhaar; Michael K Lee; Alessandra Musso; Olga Pletnikova; Juan C Troncoso; Saskia Biskup; Darren J Moore
Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.
Human molecular genetics 2012;21(11):2420-31.
2012: Paul J Tuite; Andrew E Tyan; Michael Garwood; Michael K Lee; Silvia Mangia; Shalom Michaeli
Magnetization transfer and adiabatic R 1ρ MRI in the brainstem of Parkinson's disease.
Parkinsonism & related disorders 2012;18(5):623-5.
2012: Emanuela Colla; Philippe Coune; Takeshi Iwatsubo; Ying Liu; Olga Pletnikova; Bernard L Schneider; Juan C Troncoso; Michael K Lee
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(10):3306-20.
2012: Emanuela Colla; Charles G Glabe; Poul H Jensen; Olga Pletnikova; Juan C Troncoso; Michael K Lee
Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(10):3301-5.
2011: David Ramonet; João Paulo L Daher; Brian M Lin; Klodjan Stafa; Jaekwang Kim; Rebecca Banerjee; Marie Westerlund; Olga Pletnikova; Liliane Glauser; Lichuan Yang; Ying Liu; Deborah A Swing; M Flint Beal; Juan C Troncoso; J Michael McCaffery; Nancy A Jenkins; Neal G Copeland; Dagmar Galter; Bobby Thomas; Michael K Lee; Ted M Dawson; Valina Dawson; Darren J Moore
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.
PloS one 2011;6(4):e18568.
2011: Bobby Thomas; Allen S Mandir; Neva West; Ying Liu; Shaida A Andrabi; Wanda Stirling; Valina Dawson; Ted M Dawson; Michael K Lee
Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation.
PloS one 2011;6(1):e16706.
2011: Ying Liu; Michael K Lee; Maria M James; Donald L Price; David R Borchelt; Juan C Troncoso; ESTHER OH
Passive (amyloid-β) immunotherapy attenuates monoaminergic axonal degeneration in the AβPPswe/PS1dE9 mice.
Journal of Alzheimer's disease : JAD 2011;23(2):271-9.
2010: Wanli Smith; Zhaohui Liu; Yideng Liang; Naoki Masuda; Debbie A Swing; Nancy A Jenkins; Neal G Copeland; Juan C Troncoso; Mikhail V Pletnikov; Ted M Dawson; Lee J Martin; Timothy H Moran; Michael K Lee; David R Borchelt; Christopher A Ross
Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model.
Human molecular genetics 2010;19(11):2087-98.
2010: Venu M Nemani; Wei Lu; Victoria Berge; Ken Nakamura; Bibiana Onoa; Michael K Lee; Farrukh A Chaudhry; Roger A Nicoll; Robert H Edwards
Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.
Neuron 2010;65(1):66-79.
2009: Qian Yang; Hua She; Marla Gearing; Emanuela Colla; Michael K Lee; John J Shacka; Zixu Mao
Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy.
Science (New York, N.Y.) 2009;323(5910):124-7.
2008: Ying Liu; Mi-Jeong Yoo; Alena V Savonenko; Wanda Stirling; Donald L Price; David R Borchelt; Laura Mamounas; W Ernest Lyons; Mary E Blue; Michael K Lee
Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(51):13805-14.
2008: Martina Bazzaro; Zhenhua Lin; Antonio Santillan-Gomez; Michael K Lee; Mei-Cheng Wang; Kwun C Chan; Robert E Bristow; Ralph Mazitschek; James Bradner; Richard B S Roden
Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(22):7340-7.
2008: Jiou Wang; Elizabeth Martin; Victoria Gonzales; David R Borchelt; Michael K Lee
Differential regulation of small heat shock proteins in transgenic mouse models of neurodegenerative diseases.
Neurobiology of aging 2008;29(4):586-97.
2008: Jeanne Tan; Esther S P Wong; Donald Kirkpatrick; Olga Pletnikova; Han Seok Ko; Shiam-Peng Tay; Michelle W L Ho; Juan C Troncoso; Steven P Gygi; Michael K Lee; Valina Dawson; Ted M Dawson; Kah Leong Lim
Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases.
Human molecular genetics 2008;17(3):431-9.
2007: Martina Bazzaro; Antonio Santillan-Gomez; Zhenhua Lin; Taylor Tang; Michael K Lee; Robert E Bristow; Ie-Ming Shih; Richard B S Roden
Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility.
The American journal of pathology 2007;171(5):1640-9.
2007: Renee M Miller; Gretchen Kiser; Tamma Kaysser-Kranich; Cindy Casaceli; Emanuela Colla; Michael K Lee; Chockalingam Palaniappan; Howard Federoff
Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD.
Experimental neurology 2007;204(1):421-32.
2006: Robert G Riekse; Ge Li; Eric C Petrie; James B Leverenz; Darcy Vavrek; Simona Vuletic; John J Albers; Thomas J Montine; Virginia M-Y Lee; Michael K Lee; Peter Seubert; Douglas Galasko; Gerard D Schellenberg; William R Hazzard; Elaine Peskind
Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid.
Journal of Alzheimer's disease : JAD 2006;10(4):399-406.
2006: Rainer Von Coelln; Bobby Thomas; Shaida A Andrabi; Kah Leong Lim; Joseph M Savitt; Roya Saffary; Wanda Stirling; Kristy J Bruno; Ellen J Hess; Michael K Lee; Valina Dawson; Ted M Dawson
Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(14):3685-96.
2006: Martina Bazzaro; Michael K Lee; Alessia Zoso; Wanda L H Stirling; Antonio Santillan-Gomez; Ie-Ming Shih; Richard B S Roden
Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis.
Cancer research 2006;66(7):3754-63.
2006: Erica L Unger; David Eve; Xiomara A Perez; Dawn K Reichenbach; Yanqun Xu; Michael K Lee; Anne M Andrews
Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice.
Neurobiology of disease 2006;21(2):431-43.
2006: Lee J Martin; Yan Pan; Ann C Price; Wanda Sterling; Neal G Copeland; Nancy A Jenkins; Donald L Price; Michael K Lee
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(1):41-50.
2005: Olga Pletnikova; Neva West; Michael K Lee; Gay Rudow; Richard L Skolasky; Ted M Dawson; Laura Marsh; Juan C Troncoso
Abeta deposition is associated with enhanced cortical alpha-synuclein lesions in Lewy body diseases.
Neurobiology of aging 2005;26(8):1183-92.
2005: Wanli Smith; Russell L Margolis; Xiaojie Li; Juan C Troncoso; Michael K Lee; Valina Dawson; Ted M Dawson; Takeshi Iwatsubo; Christopher A Ross
Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(23):5544-52.
2005: Wenxue Li; Michael K Lee
Antiapoptotic property of human alpha-synuclein in neuronal cell lines is associated with the inhibition of caspase-3 but not caspase-9 activity.
Journal of neurochemistry 2005;93(6):1542-50.
2005: Wenxue Li; Neva West; Emanuela Colla; Olga Pletnikova; Juan C Troncoso; Laura Marsh; Ted M Dawson; Pekka Jäkälä; Tobias Hartmann; Donald L Price; Michael K Lee
Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):2162-7.
2005: Darren J Moore; Li Zhang; Juan C Troncoso; Michael K Lee; Nobutaka Hattori; Yoshikuni Mizuno; Ted M Dawson; Valina Dawson
Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress.
Human molecular genetics 2005;14(1):71-84.
2004: David M Weiner; Herbert Y Meltzer; isaac veinbergs; E M Donohue; Tracy A Spalding; T T Smith; Nina Mohell; Scott C Harvey; Jelveh Lameh; Norman R Nash; Kimberly E Vanover; Roger Olsson; K Jayathilake; Michael K Lee; Allan Levey; Uli Hacksell; Ethan S Burstein; Robert E Davis; Mark R Brann
The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine.
Psychopharmacology 2004;177(1-2):207-16.
2004: Wenxue Li; Christian Lesuisse; Yanqun Xu; Juan C Troncoso; Donald L Price; Michael K Lee
Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(33):7400-9.
2004: Joanna Jankowsky; Daniel J Fadale; Jeffrey Anderson; Guilian Xu; Victoria Gonzales; Nancy A Jenkins; Neal G Copeland; Michael K Lee; Linda Younkin; Steven L Wagner; Steven G Younkin; David R Borchelt
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.
Human molecular genetics 2004;13(2):159-70.
2004: Wenxue Li; Paul N Hoffman; Wanda Stirling; Donald L Price; Michael K Lee
Axonal transport of human alpha-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations.
Journal of neurochemistry 2004;88(2):401-10.
2002: Orly Lazarov; Michael K Lee; Daniel A Peterson; Sangram S Sisodia
Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(22):9785-93.
2002: Ted M Dawson; Allen S Mandir; Michael K Lee
Animal models of PD: pieces of the same puzzle?
Neuron 2002;35(2):219-22.
2002: Michael K Lee; Wanda Stirling; Yanqun Xu; Xueying Xu; Dike Qui; Allen S Mandir; Ted M Dawson; Neal G Copeland; Nancy A Jenkins; Donald L Price
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8968-73.
2002: David R Borchelt; Michael K Lee; Victoria Gonzales; Hilda H Slunt; TAMARA RATOVITSKI; Nancy A Jenkins; Neal G Copeland; Donald L Price; Sangram S Sisodia
Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice.
Neurobiology of aging 2002;23(2):171-7.
2001: H F Dovey; V John; J P Anderson; L Z Chen; P de Saint Andrieu; L Y Fang; S B Freedman; B Folmer; E Goldbach; Elzbieta Holsztynska; K L Hu; K L Johnson-Wood; S L Kennedy; D Kholodenko; J E Knops; L H Latimer; Michael K Lee; Z Liao; I Lieberburg; R N Motter; L C Mutter; J Nietz; K P Quinn; K L Sacchi; Peter Seubert; G M Shopp; E D Thorsett; jay tung; J Wu; S Yang; C T Yin; Dale Schenk; Patrick May; L D Altstiel; M H Bender; L N Boggs; T C Britton; J C Clemens; D L Czilli; D K Dieckman-McGinty; J J Droste; K S Fuson; B D Gitter; P A Hyslop; E M Johnstone; W Y Li; S P Little; T E Mabry; F D Miller; J E Audia
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain.
Journal of neurochemistry 2001;76(1):173-81.
2000: S H Zaman; Angèle T Parent; A Laskey; Michael K Lee; David R Borchelt; Sangram S Sisodia; Roberto Malinow
Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine.
Neurobiology of disease 2000;7(1):54-63.
2000: GS Kelner; Michael K Lee; M E Clark; D Maciejewski; D McGrath; Shahrooz Rabizadeh; T Lyons; Dale E Bredesen; P Jenner; Richard A Maki
The copper transport protein Atox1 promotes neuronal survival.
The Journal of biological chemistry 2000;275(1):580-4.
2000: Donald L Price; Philip C Wong; Alicja L Markowska; Michael K Lee; G Thinakaren; Don W Cleveland; Sangram S Sisodia; David R Borchelt
The value of transgenic models for the study of neurodegenerative diseases.
Annals of the New York Academy of Sciences 2000;920():179-91.
1999: Takeshi Ishihara; Ming Hong; Bin Zhang; Y Nakagawa; Michael K Lee; John Q Trojanowski; Virginia M-Y Lee
Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform.
Neuron 1999;24(3):751-62.
1998: David R Borchelt; Philip C Wong; Mark W Becher; CARLOS PARDO-VILLAMIZAR; Michael K Lee; Z S Xu; Gopal Thinakaran; Nancy A Jenkins; Neal G Copeland; Sangram S Sisodia; Don W Cleveland; Donald L Price; Paul N Hoffman
Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice.
Neurobiology of disease 1998;5(1):27-35.
1998: Juan C Troncoso; Anne M Cataldo; Ralph A. Nixon; J L Barnett; Michael K Lee; F Checler; David R Fowler; John E Smialek; Barbara J Crain; Lee J Martin; Claudia H Kawas
Neuropathology of preclinical and clinical late-onset Alzheimer's disease.
Annals of neurology 1998;43(5):673-6.
1998: Philip C Wong; David R Borchelt; Michael K Lee; CARLOS PARDO-VILLAMIZAR; Gopal Thinakaran; Lee J Martin; Sangram S Sisodia; Donald L Price
Familial amyotrophic lateral sclerosis and Alzheimer's disease. Transgenic models.
Advances in experimental medicine and biology 1998;446():145-59.
1997: A Bergin; G Kim; Donald L Price; Sangram S Sisodia; Michael K Lee; B A Rabin
Identification and characterization of a mouse homologue of the spinal muscular atrophy-determining gene, survival motor neuron.
Gene 1997;204(1-2):47-53.
1997: David R Borchelt; TAMARA RATOVITSKI; J van Lare; Michael K Lee; Victoria Gonzales; Nancy A Jenkins; Neal G Copeland; Donald L Price; Sangram S Sisodia
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.
Neuron 1997;19(4):939-45.
1997: Donald L Price; Philip C Wong; David R Borchelt; CARLOS PARDO-VILLAMIZAR; Gopal Thinakaran; AP Doan; Michael K Lee; Lee J Martin; Sangram S Sisodia
Amyotrophic lateral sclerosis and Alzheimer disease. Lessons from model systems.
Revue neurologique 1997;153(8-9):484-95.
1997: Michael K Lee; David R Borchelt; G Kim; Gopal Thinakaran; Hilda H Slunt; TAMARA RATOVITSKI; Lee J Martin; A Kittur; Sam Gandy; Allan Levey; Nancy Jenkins; Neal G Copeland; Donald L Price; Sangram S Sisodia
Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.
Nature medicine 1997;3(7):756-60.
1997: Lucie I Bruijn; Mark W Becher; Michael K Lee; K L Anderson; N A Jenkins; N G Copeland; Sangram S Sisodia; Jeffrey rothstein; David R Borchelt; Donald L Price; Don W Cleveland
ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.
Neuron 1997;18(2):327-38.
1996: D Levitan; T G Doyle; D Brousseau; Michael K Lee; Gopal Thinakaran; Hilda H Slunt; Sangram S Sisodia; Iva Greenwald
Assessment of normal and mutant human presenilin function in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14940-4.
1996: David R Borchelt; J Davis; M Fischer; Michael K Lee; Hilda H Slunt; T Ratovitsky; J Regard; Neal G Copeland; Nancy A Jenkins; Sangram S Sisodia; Donald L Price
A vector for expressing foreign genes in the brains and hearts of transgenic mice.
Genetic analysis : biomolecular engineering 1996;13(6):159-63.
1996: Michael K Lee; Hilda H Slunt; Lee J Martin; Gopal Thinakaran; G Kim; Sam Gandy; M Seeger; Edward H Koo; Donald L Price; Sangram S Sisodia
Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(23):7513-25.
1996: C S Arnold; Gail Johnson; Robert N Cole; D L Dong; Michael K Lee; Gerald W Hart
The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine.
The Journal of biological chemistry 1996;271(46):28741-4.
1996: David R Borchelt; Gopal Thinakaran; Christopher B Eckman; Michael K Lee; F Davenport; T Ratovitsky; CM Prada; G Kim; S Seekins; Debra Yager; Hilda H Slunt; Rong Wang; M Seeger; Allan Levey; Sam Gandy; Neal G Copeland; Nancy A Jenkins; Donald L Price; Steven G Younkin; Sangram S Sisodia
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.
Neuron 1996;17(5):1005-13.
1996: J R Marszalek; Timothy L Williamson; Michael K Lee; Z Xu; Paul N Hoffman; Mark W Becher; Thomas O Crawford; Don W Cleveland
Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport.
The Journal of cell biology 1996;135(3):711-24.
1996: Donald L Price; Mark W Becher; Philip C Wong; David R Borchelt; Michael K Lee; Sangram S Sisodia
Inherited neurodegenerative diseases and transgenic models.
Brain pathology (Zurich, Switzerland) 1996;6(4):467-80.
1996: Michael K Lee; David R Borchelt; Philip C Wong; Sangram S Sisodia; Donald L Price
Transgenic models of neurodegenerative diseases.
Current opinion in neurobiology 1996;6(5):651-60.
1996: Don W Cleveland; Lucie I Bruijn; Philip C Wong; J R Marszalek; J D Vechio; Michael K Lee; X S Xu; David R Borchelt; Sangram S Sisodia; Donald L Price
Mechanisms of selective motor neuron death in transgenic mouse models of motor neuron disease.
Neurology 1996;47(4 Suppl 2):S54-61; discussion S61-2.
1996: Gopal Thinakaran; David R Borchelt; Michael K Lee; Hilda H Slunt; L Spitzer; G Kim; T Ratovitsky; F Davenport; C Nordstedt; M Seeger; John Hardy; Allan Levey; Sam Gandy; Nancy A Jenkins; Neal G Copeland; Donald L Price; Sangram S Sisodia
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
Neuron 1996;17(1):181-90.
1996: J M Litersky; Gail Johnson; R Jakes; Michel Goedert; Michael K Lee; Peter Seubert
Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356.
The Biochemical journal 1996;316 ( Pt 2)():655-60.
1996: Z Xu; J R Marszalek; Michael K Lee; Philip C Wong; J Folmer; Thomas O Crawford; Sung-Tsang Hsieh; John W Griffin; Don W Cleveland
Subunit composition of neurofilaments specifies axonal diameter.
The Journal of cell biology 1996;133(5):1061-9.
1996: M Wiedau-Pazos; J J Goto; Shahrooz Rabizadeh; Edith Butler Gralla; J A Roe; Michael K Lee; Joan Selverstone Valentine; Dale E Bredesen
Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis.
Science (New York, N.Y.) 1996;271(5248):515-8.
1996: Donald L Price; David R Borchelt; Philip C Wong; CARLOS PARDO-VILLAMIZAR; Gopal Thinakaran; Michael K Lee; Don W Cleveland; Sangram S Sisodia
Neurodegenerative diseases and model systems.
Cold Spring Harbor symposia on quantitative biology 1996;61():725-38.
1996: Timothy L Williamson; J R Marszalek; J D Vechio; Lucie I Bruijn; Michael K Lee; Z Xu; R H Brown; Don W Cleveland
Neurofilaments, radial growth of axons, and mechanisms of motor neuron disease.
Cold Spring Harbor symposia on quantitative biology 1996;61():709-23.
1996: Donald L Price; Vassilis E Koliatsos; Philip C Wong; CARLOS PARDO-VILLAMIZAR; David R Borchelt; Michael K Lee; Don W Cleveland; John W Griffin; Paul N Hoffman; L C Cork; Sangram S Sisodia
Motor neuron disease and model systems: aetiologies, mechanisms and therapies.
Ciba Foundation symposium 1996;196():3-13; discussion 13-7.
1996: Michael K Lee; Don W Cleveland
Neuronal intermediate filaments.
Annual review of neuroscience 1996;19():187-217.
1995: Philip C Wong; CARLOS PARDO-VILLAMIZAR; David R Borchelt; Michael K Lee; Neal G Copeland; Nancy A Jenkins; Sangram S Sisodia; Don W Cleveland; Donald L Price
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria.
Neuron 1995;14(6):1105-16.
1995: Shahrooz Rabizadeh; Edith Butler Gralla; David R Borchelt; R Gwinn; Joan Selverstone Valentine; Sangram S Sisodia; Philip C Wong; Michael K Lee; H Hahn; Dale E Bredesen
Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):3024-8.
1995: David R Borchelt; M Guarnieri; Philip C Wong; Michael K Lee; H S Slunt; Z S Xu; Sangram S Sisodia; Donald L Price; Don W Cleveland
Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function.
The Journal of biological chemistry 1995;270(7):3234-8.
1995: J Knops; S Suomensaari; Michael K Lee; Lisa McConlogue; Peter Seubert; Sukanto Sinha
Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases.
The Journal of biological chemistry 1995;270(6):2419-22.
1994: Michael K Lee; J R Marszalek; Don W Cleveland
A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease.
Neuron 1994;13(4):975-88.
1994: David R Borchelt; Michael K Lee; H S Slunt; M Guarnieri; Z S Xu; Philip C Wong; R H Brown; Donald L Price; Sangram S Sisodia; Don W Cleveland
Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(17):8292-6.
1994: Michael K Lee; Don W Cleveland
Neurofilament function and dysfunction: involvement in axonal growth and neuronal disease.
Current opinion in cell biology 1994;6(1):34-40.
1993: Michael K Lee; Z Xu; Philip C Wong; Don W Cleveland
Neurofilaments are obligate heteropolymers in vivo.
The Journal of cell biology 1993;122(6):1337-50.
1991: J E Alexander; Donald F Hunt; Michael K Lee; Jeffrey Shabanowitz; H Michel; S C Berlin; Timothy L MacDonald; R J Sundberg; L I Rebhun; Anthony Frankfurter
Characterization of posttranslational modifications in neuron-specific class III beta-tubulin by mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(11):4685-9.
1990: Michael K Lee; L I Rebhun; Anthony Frankfurter
Posttranslational modification of class III beta-tubulin.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(18):7195-9.
1990: Michael K Lee; Jeremy Tuttle; L I Rebhun; D W Cleveland; Anthony Frankfurter
The expression and posttranslational modification of a neuron-specific beta-tubulin isotype during chick embryogenesis.
Cell motility and the cytoskeleton 1990;17(2):118-32.
1988: Michael K Lee; S N Graham; Ernest Paul Gold
Memory enhancement with posttraining intraventricular glucose injections in rats.
Behavioral neuroscience 1988;102(4):591-5.